3FLP

crystal structure of native heptameric sap-like pentraxin from limulus polyphemus

• Total interactions analyzed: 91
• Total true interactions: 35
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 76
  • Norm. En. per Res.: -3.6441
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-72.944	48.1318	-239.224	-264.0362	76	9	14	10150	0	30	18
A-C	-38.5531	-53.0734	-142.843	-234.4694	74	6	3	5997	6	17	23
A-D	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	0	0
A-M	-46.3602	-54.8148	-149.568	-250.743	72	7	3	6026	5	17	21
A-N	0.0	0.0	-69.5839	-69.5839	40	3	0	2884	0	4	11
B-C	0.0	0.0	-64.5991	-64.5991	40	3	0	2731	0	4	11
B-D	-41.1472	-50.0968	-146.329	-237.5731	76	10	3	6056	5	17	23
B-M	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
B-N	-43.8809	-53.873	-147.05	-244.8039	74	6	3	5902	5	17	22
C-D	-70.7144	45.765	-239.446	-264.3954	76	9	14	10155	0	30	18
C-E	-46.6319	-59.1026	-148.862	-254.5965	74	5	3	6046	5	17	21
C-F	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
D-E	0.0	0.0	-69.2203	-69.2203	45	1	0	2879	0	4	11
D-F	-52.1528	-65.9336	-147.75	-265.8363	75	10	3	6052	6	17	23
E-F	-78.4888	50.5847	-249.05	-276.9541	76	11	14	10444	0	30	18
E-G	-42.9221	-58.4745	-144.709	-246.1056	74	7	3	5993	5	17	23
E-H	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
F-G	0.0	0.0	-68.1417	-68.1417	41	1	0	2889	0	4	11
F-H	-51.3007	-69.696	-149.915	-270.9117	76	12	3	6176	6	17	22
G-H	-77.6074	49.1977	-247.055	-275.4648	76	13	14	10374	0	30	18
G-I	-49.139	-59.9727	-146.848	-255.9598	74	6	3	6021	6	17	23
G-J	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	0	0
H-I	0.0	0.0	-65.533	-65.533	41	2	0	2813	0	4	11
H-J	-48.1242	-46.3193	-151.145	-245.5886	74	13	3	6201	6	17	23
I-J	-70.8352	48.5077	-241.411	-263.7386	76	9	14	10204	0	30	18
I-K	-46.6382	-52.825	-149.416	-248.8792	75	6	3	6026	5	17	21
I-L	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
J-K	0.0	0.0	-71.7392	-71.7392	43	3	0	2923	0	4	11
J-L	-52.6547	-56.8585	-147.35	-256.8632	72	7	3	6010	6	17	22
K-L	-80.5526	51.9856	-240.369	-268.936	76	11	14	10116	0	30	17
K-M	-40.0284	-36.8741	-143.933	-220.8355	71	4	3	6007	5	17	23
K-N	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
L-M	0.0	0.0	-66.1269	-66.1269	42	1	0	2753	0	4	11
L-N	-52.1043	-46.6373	-148.287	-247.0286	72	8	3	6032	4	17	23
M-N	-71.1616	50.7649	-239.265	-259.6618	76	9	14	10096	0	30	18

Interface residues

• A-B: ALA1A, ALA1B, ALA203A, ALA203B, ARG190A, ARG190B, ARG23A, ARG23B, ARG5A, ARG5B, ASP199A, ASP199B, ASP204A, ASP204B, ASP205A, ASP205B, ASP3A, ASP3B, ASP6A, ASP6B, GLU198A, GLU198B, GLY206A, GLY206B, GLY210A, GLY210B, HIS213A, HIS213B, HIS21A, HIS21B, ILE208A, ILE208B, ILE211A, ILE211B, ILE4A, ILE4B, ILE9A, ILE9B, LEU22A, LEU22B, LYS18A, LYS18B, LYS8A, LYS8B, MET197A, MET197B, MET25A, MET25B, PHE201A, PHE201B, PHE24A, PHE24B, PRO12A, PRO12B, PRO20A, PRO20B, SER10A, SER10B, SER195A, SER195B, SER200A, SER200B, SER212A, SER212B, TRP196A, TRP196B, VAL202A, VAL202B, VAL207A, VAL207B, VAL209A, VAL209B, VAL2A, VAL2B, VAL7A, VAL7B
• A-C: ALA172C, ALA182C, ALA1A, ALA30C, ARG112C, ARG188C, ARG190C, ARG32C, ARG45A, ASN185A, ASN192C, ASP110C, ASP170C, CYS184A, CYS215A, CYS37C, GLN133C, GLN167C, GLN177C, GLN33C, GLN98A, GLU126C, GLU162A, GLU171C, GLU93A, GLU95A, GLY108C, GLY111C, GLY13A, GLY161A, GLY191C, GLY210A, GLY97A, HIS176C, HIS213A, HIS44A, ILE187C, ILE208A, ILE211A, ILE94A, LEU173C, LEU217A, LEU96A, LYS130C, LYS18A, LYS41A, LYS8A, MET214A, PHE11A, PHE43A, PRO12A, PRO189C, PRO20A, PRO29C, PRO42A, SER107C, SER10A, SER160A, SER179C, SER212A, SER216A, THR174C, THR175C, THR180C, THR35C, TRP106C, TRP169C, TRP99A, TYR100A, VAL105C, VAL109C, VAL178C, VAL181C, VAL193C
• A-D: ALA1A, ALA1D
• A-M: ALA172A, ALA182A, ALA1M, ALA30A, ARG112A, ARG188A, ARG190A, ARG32A, ARG45M, ASN185M, ASN192A, ASP110A, ASP170A, CYS184M, CYS215M, CYS37A, GLN133A, GLN167A, GLN177A, GLN33A, GLN98M, GLU126A, GLU162M, GLU171A, GLU93M, GLU95M, GLY108A, GLY111A, GLY13M, GLY161M, GLY191A, GLY210M, GLY97M, HIS176A, HIS213M, HIS44M, ILE187A, ILE208M, ILE211M, ILE94M, LEU173A, LEU217M, LEU96M, LYS130A, LYS41M, LYS8M, MET214M, PHE11M, PHE43M, PRO12M, PRO189A, PRO29A, PRO42M, SER107A, SER10M, SER160M, SER179A, SER212M, SER216M, THR174A, THR175A, THR180A, THR35A, TRP106A, TRP169A, TRP99M, TYR100M, VAL105A, VAL109A, VAL178A, VAL181A, VAL193A
• A-N: ALA136A, ALA136N, ALA30A, ALA30N, ARG23N, ARG32N, ASN192A, ASN192N, ASP170A, ASP170N, ASP199A, ASP199N, GLN133N, GLN26A, GLN26N, GLU198A, GLU198N, GLY137A, GLY137N, GLY138A, GLY138N, ILE194A, ILE194N, LEU28A, LEU28N, MET25A, MET25N, PHE24A, PHE24N, PRO29A, PRO29N, SER200A, SER200N, THR27A, THR27N, VAL140A, VAL193A, VAL193N, VAL31A, VAL31N
• B-C: ALA136B, ALA136C, ALA30B, ALA30C, ARG23C, ARG32C, ASN192B, ASN192C, ASP170B, ASP170C, ASP199B, ASP199C, GLN133C, GLN26B, GLN26C, GLU198B, GLU198C, GLY137B, GLY137C, GLY138B, GLY138C, ILE194B, ILE194C, LEU28B, LEU28C, MET25B, MET25C, PHE24B, PHE24C, PRO29B, PRO29C, SER200B, SER200C, THR27B, THR27C, VAL140B, VAL193B, VAL193C, VAL31B, VAL31C
• B-D: ALA114B, ALA172B, ALA182B, ALA1D, ALA30B, ARG112B, ARG188B, ARG190B, ARG32B, ARG45D, ASN118D, ASN185D, ASN192B, ASP110B, ASP170B, CYS184D, CYS215D, CYS37B, GLN133B, GLN167B, GLN177B, GLN33B, GLN98D, GLU126B, GLU162D, GLU171B, GLU93D, GLU95D, GLY108B, GLY111B, GLY13D, GLY161D, GLY191B, GLY210D, GLY97D, HIS176B, HIS213D, HIS44D, ILE187B, ILE208D, ILE211D, ILE94D, LEU173B, LEU217D, LEU96D, LYS130B, LYS41D, LYS8D, MET214D, PHE11D, PHE43D, PRO12D, PRO189B, PRO29B, PRO42D, SER107B, SER10D, SER160D, SER179B, SER212D, SER216D, THR124B, THR174B, THR175B, THR180B, THR35B, TRP106B, TRP169B, TRP99D, TYR100D, VAL105B, VAL109B, VAL178B, VAL181B, VAL193B, VAL2D
• B-M: ALA1B, ALA1M
• B-N: ALA172N, ALA182N, ALA1B, ALA30N, ARG112N, ARG188N, ARG190N, ARG32N, ARG45B, ASN185B, ASN192N, ASP110N, ASP170N, CYS184B, CYS215B, CYS37N, GLN133N, GLN167N, GLN177N, GLN33N, GLN98B, GLU126N, GLU162B, GLU171N, GLU93B, GLU95B, GLY108N, GLY111N, GLY13B, GLY161B, GLY191N, GLY210B, GLY97B, HIS176N, HIS213B, HIS44B, ILE187N, ILE208B, ILE211B, ILE94B, LEU173N, LEU217B, LEU96B, LYS130N, LYS18B, LYS41B, LYS8B, MET214B, PHE11B, PHE43B, PRO12B, PRO189N, PRO20B, PRO29N, PRO42B, SER107N, SER10B, SER160B, SER179N, SER212B, SER216B, THR174N, THR175N, THR180N, THR35N, TRP106N, TRP169N, TRP99B, TYR100B, VAL105N, VAL109N, VAL178N, VAL181N, VAL193N
• C-D: ALA1C, ALA1D, ALA203C, ALA203D, ARG190C, ARG190D, ARG23C, ARG23D, ARG5C, ARG5D, ASP199C, ASP199D, ASP204C, ASP204D, ASP205C, ASP205D, ASP3C, ASP3D, ASP6C, ASP6D, GLU198C, GLU198D, GLY206C, GLY206D, GLY210C, GLY210D, HIS213C, HIS213D, HIS21C, HIS21D, ILE208C, ILE208D, ILE211C, ILE211D, ILE4C, ILE4D, ILE9C, ILE9D, LEU22C, LEU22D, LYS18C, LYS18D, LYS8C, LYS8D, MET197C, MET197D, MET25C, MET25D, PHE201C, PHE201D, PHE24C, PHE24D, PRO12C, PRO12D, PRO20C, PRO20D, SER10C, SER10D, SER195C, SER195D, SER200C, SER200D, SER212C, SER212D, TRP196C, TRP196D, VAL202C, VAL202D, VAL207C, VAL207D, VAL209C, VAL209D, VAL2C, VAL2D, VAL7C, VAL7D
• C-E: ALA172E, ALA182E, ALA1C, ALA30E, ARG112E, ARG188E, ARG190E, ARG32E, ARG45C, ASN185C, ASN192E, ASP110E, ASP170E, CYS184C, CYS215C, CYS37E, GLN133E, GLN167E, GLN177E, GLN33E, GLN98C, GLU126E, GLU162C, GLU171E, GLU93C, GLU95C, GLY108E, GLY111E, GLY13C, GLY161C, GLY191E, GLY210C, GLY97C, HIS176E, HIS213C, HIS44C, ILE187E, ILE208C, ILE211C, ILE94C, LEU173E, LEU217C, LEU96C, LYS130E, LYS41C, LYS8C, MET214C, PHE11C, PHE43C, PRO12C, PRO189E, PRO29E, PRO42C, SER107E, SER10C, SER160C, SER179E, SER212C, SER216C, THR124E, THR174E, THR175E, THR180E, THR35E, TRP106E, TRP169E, TRP99C, TYR100C, VAL105E, VAL109E, VAL178E, VAL181E, VAL193E, VAL2C
• C-F: ALA1C, ALA1F
• D-E: ALA136D, ALA136E, ALA30D, ALA30E, ARG23D, ARG23E, ARG32D, ARG32E, ASN192D, ASN192E, ASP170D, ASP170E, ASP199D, ASP199E, GLN133D, GLN133E, GLN26D, GLN26E, GLU198D, GLU198E, GLY137D, GLY137E, GLY138D, GLY138E, ILE194D, ILE194E, LEU28D, LEU28E, MET25D, MET25E, PHE24D, PHE24E, PRO29D, PRO29E, SER200D, SER200E, THR139E, THR27D, THR27E, VAL140D, VAL140E, VAL193D, VAL193E, VAL31D, VAL31E
• D-F: ALA114D, ALA172D, ALA182D, ALA1F, ALA30D, ARG112D, ARG188D, ARG190D, ARG32D, ARG45F, ASN185F, ASN192D, ASP110D, ASP170D, CYS184F, CYS215F, CYS37D, GLN133D, GLN167D, GLN177D, GLN33D, GLN98F, GLU126D, GLU162F, GLU171D, GLU93F, GLU95F, GLY108D, GLY111D, GLY13F, GLY161F, GLY191D, GLY210F, GLY97F, HIS176D, HIS213F, HIS44F, ILE187D, ILE208F, ILE211F, ILE94F, LEU173D, LEU217F, LEU96F, LYS130D, LYS18F, LYS41F, LYS8F, MET214F, PHE11F, PHE43F, PRO12F, PRO189D, PRO20F, PRO29D, PRO42F, SER107D, SER10F, SER160F, SER179D, SER212F, SER216F, THR174D, THR175D, THR180D, THR35D, TRP106D, TRP169D, TRP99F, TYR100F, VAL105D, VAL109D, VAL178D, VAL181D, VAL193D
• E-F: ALA1E, ALA1F, ALA203E, ALA203F, ARG190E, ARG190F, ARG23E, ARG23F, ARG5E, ARG5F, ASP199E, ASP199F, ASP204E, ASP204F, ASP205E, ASP205F, ASP3E, ASP3F, ASP6E, ASP6F, GLU198E, GLU198F, GLY206E, GLY206F, GLY210E, GLY210F, HIS213E, HIS213F, HIS21E, HIS21F, ILE208E, ILE208F, ILE211E, ILE211F, ILE4E, ILE4F, ILE9E, ILE9F, LEU22E, LEU22F, LYS18E, LYS18F, LYS8E, LYS8F, MET197E, MET197F, MET25E, MET25F, PHE201E, PHE201F, PHE24E, PHE24F, PRO12E, PRO12F, PRO20E, PRO20F, SER10E, SER10F, SER195E, SER195F, SER200E, SER200F, SER212E, SER212F, TRP196E, TRP196F, VAL202E, VAL202F, VAL207E, VAL207F, VAL209E, VAL209F, VAL2E, VAL2F, VAL7E, VAL7F
• E-G: ALA114G, ALA172G, ALA182G, ALA1E, ALA30G, ARG112G, ARG188G, ARG190G, ARG32G, ARG45E, ASN185E, ASN192G, ASP110G, ASP170G, CYS184E, CYS215E, CYS37G, GLN133G, GLN167G, GLN177G, GLN33G, GLN98E, GLU126G, GLU162E, GLU171G, GLU93E, GLU95E, GLY108G, GLY111G, GLY13E, GLY161E, GLY191G, GLY210E, GLY97E, HIS176G, HIS213E, HIS44E, ILE187G, ILE208E, ILE211E, ILE94E, LEU173G, LEU217E, LEU96E, LYS130G, LYS41E, LYS8E, MET214E, PHE11E, PHE43E, PRO12E, PRO189G, PRO29G, PRO42E, SER107G, SER10E, SER160E, SER179G, SER212E, SER216E, THR174G, THR175G, THR180G, THR35G, TRP106G, TRP169G, TRP99E, TYR100E, VAL105G, VAL109G, VAL178G, VAL181G, VAL193G, VAL2E
• E-H: ALA1E, ALA1H
• F-G: ALA136F, ALA136G, ALA30F, ALA30G, ARG32F, ASN192F, ASN192G, ASP170F, ASP170G, ASP199F, ASP199G, GLN133F, GLN133G, GLN26F, GLN26G, GLU198F, GLU198G, GLY137F, GLY137G, GLY138F, GLY138G, ILE194F, ILE194G, LEU28F, LEU28G, MET25F, MET25G, PHE24F, PHE24G, PRO29F, PRO29G, SER200F, SER200G, THR139G, THR27F, THR27G, VAL140G, VAL193F, VAL193G, VAL31F, VAL31G
• F-H: ALA114F, ALA172F, ALA182F, ALA1H, ALA30F, ARG112F, ARG188F, ARG190F, ARG32F, ARG45H, ASN185H, ASN192F, ASP110F, ASP170F, CYS184H, CYS215H, CYS37F, GLN133F, GLN167F, GLN177F, GLN33F, GLN98H, GLU126F, GLU162H, GLU171F, GLU93H, GLU95H, GLY108F, GLY111F, GLY13H, GLY161H, GLY191F, GLY210H, GLY97H, HIS176F, HIS213H, HIS44H, ILE187F, ILE208H, ILE211H, ILE94H, LEU173F, LEU217H, LEU96H, LYS130F, LYS41H, LYS8H, MET214H, PHE11H, PHE43H, PRO12H, PRO189F, PRO20H, PRO29F, PRO42H, SER107F, SER10H, SER160H, SER179F, SER212H, SER216H, THR124F, THR174F, THR175F, THR180F, THR35F, TRP106F, TRP169F, TRP99H, TYR100H, VAL105F, VAL109F, VAL178F, VAL181F, VAL193F, VAL2H
• G-H: ALA1G, ALA1H, ALA203G, ALA203H, ARG190G, ARG190H, ARG23G, ARG23H, ARG5G, ARG5H, ASP199G, ASP199H, ASP204G, ASP204H, ASP205G, ASP205H, ASP3G, ASP3H, ASP6G, ASP6H, GLU198G, GLU198H, GLY206G, GLY206H, GLY210G, GLY210H, HIS213G, HIS213H, HIS21G, HIS21H, ILE208G, ILE208H, ILE211G, ILE211H, ILE4G, ILE4H, ILE9G, ILE9H, LEU22G, LEU22H, LYS18G, LYS18H, LYS8G, LYS8H, MET197G, MET197H, MET25G, MET25H, PHE201G, PHE201H, PHE24G, PHE24H, PRO12G, PRO12H, PRO20G, PRO20H, SER10G, SER10H, SER195G, SER195H, SER200G, SER200H, SER212G, SER212H, TRP196G, TRP196H, VAL202G, VAL202H, VAL207G, VAL207H, VAL209G, VAL209H, VAL2G, VAL2H, VAL7G, VAL7H
• G-I: ALA114I, ALA172I, ALA182I, ALA1G, ALA30I, ARG112I, ARG188I, ARG190I, ARG32I, ARG45G, ASN118G, ASN185G, ASN192I, ASP110I, ASP170I, CYS184G, CYS215G, CYS37I, GLN133I, GLN167I, GLN177I, GLN33I, GLN98G, GLU126I, GLU162G, GLU171I, GLU93G, GLU95G, GLY108I, GLY111I, GLY13G, GLY161G, GLY191I, GLY210G, GLY97G, HIS176I, HIS213G, HIS44G, ILE187I, ILE208G, ILE211G, ILE94G, LEU173I, LEU217G, LEU96G, LYS130I, LYS41G, LYS8G, MET214G, PHE11G, PHE43G, PRO12G, PRO189I, PRO29I, PRO42G, SER107I, SER10G, SER160G, SER179I, SER212G, SER216G, THR124I, THR174I, THR175I, THR180I, THR35I, TRP106I, TRP169I, TRP99G, VAL105I, VAL109I, VAL178I, VAL181I, VAL193I
• G-J: ALA1G, ALA1J
• H-I: ALA136H, ALA136I, ALA30H, ALA30I, ARG23I, ASN192H, ASN192I, ASP170H, ASP170I, ASP199H, ASP199I, GLN133H, GLN26H, GLN26I, GLU198H, GLU198I, GLY137H, GLY137I, GLY138H, GLY138I, ILE194H, ILE194I, LEU28H, LEU28I, MET25H, MET25I, PHE24H, PHE24I, PRO29H, PRO29I, SER200H, SER200I, THR139I, THR27H, THR27I, VAL140H, VAL140I, VAL193H, VAL193I, VAL31H, VAL31I
• H-J: ALA114H, ALA172H, ALA182H, ALA1J, ALA30H, ARG112H, ARG188H, ARG190H, ARG32H, ARG45J, ASN185J, ASN192H, ASP110H, ASP170H, CYS184J, CYS215J, CYS37H, GLN133H, GLN167H, GLN177H, GLN33H, GLN98J, GLU126H, GLU162J, GLU171H, GLU93J, GLU95J, GLY108H, GLY111H, GLY13J, GLY161J, GLY191H, GLY210J, GLY97J, HIS176H, HIS213J, HIS44J, ILE187H, ILE208J, ILE211J, ILE94J, LEU173H, LEU217J, LEU96J, LYS130H, LYS41J, LYS8J, MET214J, PHE11J, PHE43J, PRO12J, PRO189H, PRO29H, PRO42J, SER107H, SER10J, SER160J, SER179H, SER212J, SER216J, THR124H, THR174H, THR175H, THR180H, THR35H, TRP106H, TRP169H, TRP99J, TYR100J, VAL105H, VAL109H, VAL178H, VAL181H, VAL193H
• I-J: ALA1I, ALA1J, ALA203I, ALA203J, ARG190I, ARG190J, ARG23I, ARG23J, ARG5I, ARG5J, ASP199I, ASP199J, ASP204I, ASP204J, ASP205I, ASP205J, ASP3I, ASP3J, ASP6I, ASP6J, GLU198I, GLU198J, GLY206I, GLY206J, GLY210I, GLY210J, HIS213I, HIS213J, HIS21I, HIS21J, ILE208I, ILE208J, ILE211I, ILE211J, ILE4I, ILE4J, ILE9I, ILE9J, LEU22I, LEU22J, LYS18I, LYS18J, LYS8I, LYS8J, MET197I, MET197J, MET25I, MET25J, PHE201I, PHE201J, PHE24I, PHE24J, PRO12I, PRO12J, PRO20I, PRO20J, SER10I, SER10J, SER195I, SER195J, SER200I, SER200J, SER212I, SER212J, TRP196I, TRP196J, VAL202I, VAL202J, VAL207I, VAL207J, VAL209I, VAL209J, VAL2I, VAL2J, VAL7I, VAL7J
• I-K: ALA114K, ALA172K, ALA182K, ALA1I, ALA30K, ARG112K, ARG188K, ARG190K, ARG32K, ARG45I, ASN185I, ASN192K, ASP110K, ASP170K, CYS184I, CYS215I, CYS37K, GLN133K, GLN167K, GLN177K, GLN33K, GLN98I, GLU126K, GLU162I, GLU171K, GLU93I, GLU95I, GLY108K, GLY111K, GLY13I, GLY161I, GLY191K, GLY210I, GLY97I, HIS176K, HIS213I, HIS44I, ILE187K, ILE208I, ILE211I, ILE94I, LEU173K, LEU217I, LEU96I, LYS130K, LYS18I, LYS41I, LYS8I, MET214I, PHE11I, PHE43I, PRO12I, PRO189K, PRO20I, PRO29K, PRO42I, SER107K, SER10I, SER160I, SER179K, SER212I, SER216I, THR174K, THR175K, THR180K, THR35K, TRP106K, TRP169K, TRP99I, TYR100I, VAL105K, VAL109K, VAL178K, VAL181K, VAL193K
• I-L: ALA1I, ALA1L
• J-K: ALA136J, ALA136K, ALA30J, ALA30K, ARG23K, ARG32J, ARG32K, ASN192J, ASN192K, ASP170J, ASP170K, ASP199J, ASP199K, GLN133J, GLN26J, GLN26K, GLU198J, GLU198K, GLY137J, GLY137K, GLY138J, GLY138K, ILE194J, ILE194K, LEU28J, LEU28K, MET25J, MET25K, PHE24J, PHE24K, PRO29J, PRO29K, SER200J, SER200K, THR139J, THR27J, THR27K, VAL140J, VAL140K, VAL193J, VAL193K, VAL31J, VAL31K
• J-L: ALA172J, ALA182J, ALA1L, ALA30J, ARG112J, ARG188J, ARG190J, ARG32J, ARG45L, ASN185L, ASN192J, ASP110J, ASP170J, CYS184L, CYS215L, CYS37J, GLN133J, GLN167J, GLN177J, GLN33J, GLN98L, GLU126J, GLU162L, GLU171J, GLU93L, GLU95L, GLY108J, GLY111J, GLY13L, GLY161L, GLY191J, GLY210L, GLY97L, HIS176J, HIS213L, HIS44L, ILE187J, ILE208L, ILE211L, ILE94L, LEU173J, LEU217L, LEU96L, LYS130J, LYS41L, LYS8L, MET214L, PHE11L, PHE43L, PRO12L, PRO189J, PRO29J, PRO42L, SER107J, SER10L, SER160L, SER179J, SER212L, SER216L, THR174J, THR175J, THR180J, THR35J, TRP106J, TRP169J, TRP99L, TYR100L, VAL105J, VAL109J, VAL178J, VAL181J, VAL193J
• K-L: ALA1K, ALA1L, ALA203K, ALA203L, ARG190K, ARG190L, ARG23K, ARG23L, ARG5K, ARG5L, ASP199K, ASP199L, ASP204K, ASP204L, ASP205K, ASP205L, ASP3K, ASP3L, ASP6K, ASP6L, GLU198K, GLU198L, GLY206K, GLY206L, GLY210K, GLY210L, HIS213K, HIS213L, HIS21K, HIS21L, ILE208K, ILE208L, ILE211K, ILE211L, ILE4K, ILE4L, ILE9K, ILE9L, LEU22K, LEU22L, LYS18K, LYS18L, LYS8K, LYS8L, MET197K, MET197L, MET25K, MET25L, PHE201K, PHE201L, PHE24K, PHE24L, PRO12K, PRO12L, PRO20K, PRO20L, SER10K, SER10L, SER195K, SER195L, SER200K, SER200L, SER212K, SER212L, TRP196K, TRP196L, VAL202K, VAL202L, VAL207K, VAL207L, VAL209K, VAL209L, VAL2K, VAL2L, VAL7K, VAL7L
• K-M: ALA172M, ALA182M, ALA1K, ALA30M, ARG112M, ARG188M, ARG190M, ARG32M, ARG45K, ASN185K, ASN192M, ASP110M, ASP170M, CYS184K, CYS215K, CYS37M, GLN133M, GLN167M, GLN177M, GLN33M, GLN98K, GLU126M, GLU162K, GLU171M, GLU93K, GLU95K, GLY108M, GLY111M, GLY13K, GLY161K, GLY191M, GLY210K, GLY97K, HIS176M, HIS213K, HIS44K, ILE187M, ILE208K, ILE211K, ILE94K, LEU173M, LEU217K, LEU96K, LYS130M, LYS41K, LYS8K, MET214K, PHE11K, PHE43K, PRO12K, PRO189M, PRO29M, PRO42K, SER107M, SER10K, SER160K, SER179M, SER212K, SER216K, THR174M, THR175M, THR180M, THR35M, TRP106M, TRP169M, TRP99K, VAL105M, VAL109M, VAL178M, VAL181M, VAL193M
• K-N: ALA1K, ALA1N
• L-M: ALA136L, ALA136M, ALA30L, ALA30M, ARG23L, ARG23M, ARG32L, ASN192L, ASN192M, ASP170L, ASP170M, ASP199L, ASP199M, GLN26L, GLN26M, GLU198L, GLU198M, GLY137L, GLY137M, GLY138L, GLY138M, ILE194L, ILE194M, LEU28L, LEU28M, MET25L, MET25M, PHE24L, PHE24M, PRO29L, PRO29M, SER200L, SER200M, THR139L, THR27L, THR27M, VAL140L, VAL140M, VAL193L, VAL193M, VAL31L, VAL31M
• L-N: ALA172L, ALA182L, ALA1N, ALA30L, ARG112L, ARG188L, ARG190L, ARG32L, ARG45N, ASN185N, ASN192L, ASP110L, ASP170L, CYS184N, CYS215N, CYS37L, GLN133L, GLN167L, GLN177L, GLN33L, GLN98N, GLU126L, GLU162N, GLU171L, GLU93N, GLU95N, GLY108L, GLY111L, GLY13N, GLY161N, GLY191L, GLY210N, GLY97N, HIS176L, HIS213N, HIS44N, ILE187L, ILE208N, ILE211N, ILE94N, LEU173L, LEU217N, LEU96N, LYS130L, LYS41N, LYS8N, MET214N, PHE11N, PHE43N, PRO12N, PRO189L, PRO29L, PRO42N, SER107L, SER10N, SER160N, SER179L, SER212N, SER216N, THR174L, THR175L, THR180L, THR35L, TRP106L, TRP169L, TRP99N, TYR100N, VAL105L, VAL109L, VAL178L, VAL181L, VAL193L
• M-N: ALA1M, ALA1N, ALA203M, ALA203N, ARG190M, ARG190N, ARG23M, ARG23N, ARG5M, ARG5N, ASP199M, ASP199N, ASP204M, ASP204N, ASP205M, ASP205N, ASP3M, ASP3N, ASP6M, ASP6N, GLU198M, GLU198N, GLY206M, GLY206N, GLY210M, GLY210N, HIS213M, HIS213N, HIS21M, HIS21N, ILE208M, ILE208N, ILE211M, ILE211N, ILE4M, ILE4N, ILE9M, ILE9N, LEU22M, LEU22N, LYS18M, LYS18N, LYS8M, LYS8N, MET197M, MET197N, MET25M, MET25N, PHE201M, PHE201N, PHE24M, PHE24N, PRO12M, PRO12N, PRO20M, PRO20N, SER10M, SER10N, SER195M, SER195N, SER200M, SER200N, SER212M, SER212N, TRP196M, TRP196N, VAL202M, VAL202N, VAL207M, VAL207N, VAL209M, VAL209N, VAL2M, VAL2N, VAL7M, VAL7N