3FI0

crystal structure analysis of b. stearothermophilus tryptophanyl-trna synthetase complexed with tryptophan, amp, and inorganic phosphate

• Total interactions analyzed: 153
• Total true interactions: 32
• Strongest Interaction:
  • Chains: O-R
  • Int. Res.: 169
  • Norm. En. per Res.: -5.0354
• Hub Node: G(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-119.1416	-142.3682	-559.68	-821.1899	173	65	17	22465	10	34	25
A-N	-13.5764	-0.3752	-26.5221	-40.4738	22	1	0	884	0	5	6
B-E	-134.755	-151.5252	-562.131	-848.4113	174	61	15	22439	10	36	25
B-O	0.0	-6.9791	-17.1034	-24.0825	19	0	0	725	0	5	5
D-C	-21.6097	-53.3189	-77.5301	-152.4587	50	7	0	3539	3	28	23
D-N	0.0	0.0	-75.9877	-75.9877	45	0	0	2451	0	10	9
D-O	-20.1234	-28.0264	-90.3485	-138.4983	54	9	0	3780	2	29	24
D-Q	-9.7369	0.0255	-23.3164	-33.0279	21	1	0	930	0	5	6
C-E	0.0	0.0	-0.0618	-0.0618	8	0	0	25	0	1	2
C-F	-131.94	-138.6059	-557.823	-828.3689	173	45	17	21693	10	34	26
E-F	0.0	0.0	-0.0177	-0.0177	2	0	0	5	0	4	6
E-G	0.0	9.0238	-1.5283	7.4955	28	5	0	886	0	13	15
E-O	0.0	1.0101	-71.1165	-70.1064	52	4	0	2680	0	12	8
E-R	0.0	-2.6151	-14.6484	-17.2635	20	0	0	720	0	7	5
G-I	-17.2886	0.961	-24.2959	-40.6235	22	11	0	919	2	5	6
G-J	-121.4941	-130.4585	-582.282	-834.2346	173	38	16	22145	10	34	24
G-K	-29.8991	-47.6721	-75.7272	-153.2984	52	8	0	3640	3	28	26
G-L	0.0	0.0	-74.5279	-74.5279	51	1	0	2470	0	14	11
G-O	0.0	0.0	-0.1021	-0.1021	5	0	0	37	0	4	7
G-R	0.0	0.0	-0.0339	-0.0339	7	0	0	16	0	3	7
H-K	-131.1149	-141.6789	-593.337	-866.1308	175	45	16	22399	10	36	25
I-K	0.0	0.0	-0.0204	-0.0204	3	0	0	16	0	1	4
I-L	-110.0984	-155.2511	-540.238	-805.5875	175	54	17	22305	9	34	26
I-N	-9.6648	-2.8071	-20.4684	-32.9403	20	2	0	793	0	4	2
I-Q	0.0	0.0	-80.3101	-80.3101	49	1	0	2542	0	10	9
J-L	-12.2205	-4.1063	-28.7951	-45.1219	21	1	0	981	0	5	6
K-L	0.0	0.0	-0.0126	-0.0126	2	0	0	3	0	4	4
L-Q	-9.9176	0.1293	-28.1861	-37.9744	21	1	0	966	1	5	6
M-P	-95.2496	-152.1616	-551.765	-799.1762	169	61	14	21863	10	35	25
M-Q	-26.093	-25.2516	-77.1579	-128.5024	54	10	0	3650	2	28	23
N-Q	-116.8988	-141.8161	-569.062	-827.7769	175	47	16	22348	9	34	25
O-R	-132.9642	-139.1994	-578.821	-850.9846	169	54	18	22445	9	36	26

Interface residues

• A-D: ALA120A, ALA120D, ALA304A, ALA304D, ALA321A, ALA321D, ALA44A, ALA44D, ALA62A, ALA62D, ALA85A, ALA85D, ALA87A, ALA87D, ALA89A, ALA89D, ALA90A, ALA90D, ARG160A, ARG160D, ARG164A, ARG164D, ARG298A, ARG298D, ARG316A, ARG316D, ARG326A, ARG326D, ARG55A, ARG55D, ARG59A, ARG59D, ASN308A, ASN308D, ASN57A, ASN57D, ASP297A, ASP297D, ASP301A, ASP301D, ASP41A, ASP41D, ASP50A, ASP50D, CYS95A, CYS95D, GLN320A, GLN320D, GLN42A, GLN42D, GLN49A, GLN49D, GLN56A, GLN56D, GLN80A, GLN80D, GLN88A, GLN88D, GLN94A, GLN94D, GLN9D, GLU101A, GLU101D, GLU103A, GLU103D, GLU294A, GLU294D, GLU295A, GLU295D, GLU302A, GLU302D, GLU305A, GLU305D, GLU319A, GLU319D, GLU53A, GLU53D, GLU82A, GLU82D, GLY100A, GLY100D, GLY121A, GLY121D, GLY303A, GLY303D, GLY323A, GLY323D, GLY325A, GLY325D, HIS43A, HIS43D, HIS52A, HIS52D, HIS86A, HIS86D, ILE39A, ILE39D, ILE45A, ILE45D, ILE58A, ILE58D, ILE79A, ILE79D, ILE96A, ILE96D, ILE99A, ILE99D, LEU102A, LEU102D, LEU122A, LEU122D, LEU123A, LEU123D, LEU128A, LEU128D, LEU296A, LEU296D, LEU300A, LEU300D, LEU324A, LEU324D, LEU54A, LEU54D, LEU93A, LEU93D, LYS317A, LYS317D, PHE161A, PHE161D, PHE78A, PHE78D, PRO126A, PRO126D, PRO127A, PRO127D, PRO51A, PRO51D, PRO84A, PRO84D, SER119A, SER119D, SER312A, SER312D, SER81A, SER81D, THR124A, THR124D, THR46A, THR46D, TRP48A, TRP48D, TRP91A, TRP91D, TYR125A, TYR125D, TYR165A, TYR165D, TYR98A, TYR98D, VAL118A, VAL118D, VAL299A, VAL299D, VAL315A, VAL315D, VAL40A, VAL40D, VAL47A, VAL47D, VAL83A, VAL83D, VAL97A, VAL97D
• A-N: ARG160A, ARG164A, ARG229N, ASN162A, ASP188N, GLU159A, GLU167A, GLU225N, GLY166A, GLY226N, GLY237N, ILE96A, LYS163A, PHE161A, PRO189N, SER224N, THR190N, THR227N, TYR165A, TYR265N, TYR98A, VAL187N
• B-E: ALA120B, ALA120E, ALA304B, ALA304E, ALA321B, ALA321E, ALA44B, ALA44E, ALA62B, ALA62E, ALA85B, ALA85E, ALA87B, ALA87E, ALA89B, ALA89E, ALA90B, ALA90E, ARG160B, ARG160E, ARG164B, ARG164E, ARG298B, ARG298E, ARG316B, ARG316E, ARG326B, ARG326E, ARG55B, ARG55E, ARG59B, ARG59E, ASN308B, ASN308E, ASN57B, ASN57E, ASP297B, ASP297E, ASP301B, ASP301E, ASP41B, ASP41E, ASP50B, ASP50E, CYS95B, CYS95E, GLN320B, GLN320E, GLN42B, GLN42E, GLN49B, GLN49E, GLN56B, GLN56E, GLN80B, GLN80E, GLN88B, GLN88E, GLN94B, GLN94E, GLU101B, GLU101E, GLU103B, GLU103E, GLU294B, GLU294E, GLU295E, GLU302B, GLU302E, GLU305B, GLU305E, GLU319B, GLU319E, GLU53B, GLU53E, GLU82B, GLU82E, GLY100B, GLY100E, GLY121B, GLY121E, GLY303B, GLY303E, GLY323B, GLY323E, GLY325B, GLY325E, HIS43B, HIS43E, HIS52B, HIS52E, HIS86B, HIS86E, ILE39B, ILE39E, ILE45B, ILE45E, ILE58B, ILE58E, ILE79B, ILE79E, ILE96B, ILE96E, ILE99B, ILE99E, LEU102B, LEU102E, LEU122B, LEU122E, LEU123B, LEU123E, LEU128B, LEU128E, LEU157E, LEU296B, LEU296E, LEU300B, LEU300E, LEU324B, LEU324E, LEU54B, LEU54E, LEU77B, LEU77E, LEU93B, LEU93E, LYS317B, LYS317E, PHE161B, PHE161E, PHE78B, PHE78E, PRO126B, PRO126E, PRO127B, PRO127E, PRO51B, PRO51E, PRO84B, PRO84E, SER119B, SER119E, SER312B, SER312E, SER81B, SER81E, THR124B, THR124E, THR46B, THR46E, TRP48B, TRP48E, TRP91B, TRP91E, TYR125B, TYR125E, TYR165B, TYR165E, TYR98B, TYR98E, VAL118B, VAL118E, VAL299B, VAL299E, VAL315B, VAL315E, VAL40B, VAL40E, VAL47B, VAL47E, VAL83B, VAL83E, VAL97B, VAL97E
• B-O: ARG164B, ARG229O, ASN162B, ASP188O, GLU159B, GLU225O, GLY226O, GLY237O, ILE96B, LYS163B, PHE161B, PRO189O, SER224O, THR190O, THR227O, TYR165B, TYR265O, TYR98B, VAL187O
• D-C: ALA270D, ALA273D, ALA304C, ALA307C, ALA75C, ARG298C, ARG309C, ASN308C, ASN34C, ASP271D, ASP301C, ASP71C, CYS35C, GLN274D, GLN30C, GLN74C, GLU214D, GLU28C, GLU302C, GLU305C, GLU32C, GLY226D, GLY262D, GLY264D, GLY266D, GLY303C, HIS31C, LEU272D, LYS201D, LYS211D, LYS215D, LYS218D, LYS263D, LYS269D, LYS2C, LYS306C, PHE268D, PRO72C, SER219D, SER224D, THR73C, THR76C, TYR245D, TYR260D, TYR265D, TYR33C, TYR36C, VAL267D, VAL275D, VAL310C
• D-N: ASN199D, ASN199N, ASP188D, ASP188N, ASP197D, ASP197N, ASP50D, ASP50N, GLN49D, GLN49N, GLU53D, GLU53N, GLY237D, GLY237N, ILE238D, ILE238N, LEU122D, LYS191D, LYS191N, LYS195D, LYS195N, LYS201N, PRO189D, PRO189N, PRO198D, PRO198N, PRO200D, PRO200N, SER119D, SER119N, SER194D, SER196D, SER196N, THR190D, THR190N, TRP48D, TRP48N, TYR203D, TYR203N, VAL118D, VAL118N, VAL187D, VAL187N, VAL47D, VAL47N
• D-O: ALA210O, ALA270O, ALA273O, ALA304D, ALA307D, ALA75D, ARG298D, ARG309D, ASN308D, ASN34D, ASP271O, ASP301D, ASP71D, CYS35D, GLN259O, GLN274O, GLN30D, GLN74D, GLU214O, GLU28D, GLU302D, GLU305D, GLU313D, GLU32D, GLY226O, GLY262O, GLY264O, GLY266O, GLY303D, HIS31D, ILE228O, LEU272O, LEU29D, LYS211O, LYS215O, LYS218O, LYS263O, LYS269O, LYS2D, LYS306D, PHE268O, PRO72D, SER219O, SER224O, SER312D, THR73D, THR76D, TYR245O, TYR260O, TYR265O, TYR33D, TYR36D, VAL267O, VAL310D
• D-Q: ARG164Q, ARG229D, ASN162Q, ASP188D, GLU159Q, GLU167Q, GLU225D, GLY166Q, GLY226D, GLY237D, ILE96Q, LYS163Q, PHE161Q, PRO189D, SER224D, THR190D, THR227D, TYR165Q, TYR265D, TYR98Q, VAL187D
• C-E: ARG298E, GLN320C, GLU167C, GLU294E, GLU295E, GLY166C, HIS289E, TYR165C
• C-F: ALA120C, ALA120F, ALA304C, ALA304F, ALA321C, ALA321F, ALA44C, ALA44F, ALA62C, ALA62F, ALA85C, ALA85F, ALA87C, ALA87F, ALA89C, ALA89F, ALA90C, ALA90F, ARG160C, ARG160F, ARG164C, ARG164F, ARG298C, ARG298F, ARG316C, ARG316F, ARG326C, ARG326F, ARG55C, ARG55F, ARG59C, ARG59F, ASN308C, ASN308F, ASN57C, ASN57F, ASP297C, ASP297F, ASP301C, ASP301F, ASP41C, ASP41F, ASP50C, ASP50F, CYS95C, CYS95F, GLN320C, GLN320F, GLN42C, GLN42F, GLN49C, GLN49F, GLN56C, GLN56F, GLN80C, GLN80F, GLN88C, GLN88F, GLN94C, GLN94F, GLU101C, GLU101F, GLU103C, GLU103F, GLU294C, GLU295C, GLU295F, GLU302C, GLU302F, GLU305C, GLU305F, GLU319C, GLU319F, GLU53C, GLU53F, GLU82C, GLU82F, GLY100C, GLY100F, GLY121C, GLY121F, GLY303C, GLY303F, GLY323C, GLY323F, GLY325C, GLY325F, HIS43C, HIS43F, HIS52C, HIS52F, HIS86C, HIS86F, ILE39C, ILE39F, ILE45C, ILE45F, ILE58C, ILE58F, ILE79C, ILE79F, ILE96C, ILE96F, ILE99C, ILE99F, LEU102C, LEU102F, LEU122C, LEU122F, LEU123C, LEU123F, LEU128C, LEU128F, LEU157C, LEU296C, LEU296F, LEU300C, LEU300F, LEU324C, LEU324F, LEU54C, LEU54F, LEU77C, LEU77F, LEU93C, LEU93F, LYS317C, LYS317F, PHE161C, PHE161F, PHE78C, PHE78F, PRO126C, PRO126F, PRO127C, PRO127F, PRO51C, PRO51F, PRO84C, PRO84F, SER119C, SER119F, SER312C, SER312F, SER81C, SER81F, THR124C, THR124F, THR46C, THR46F, TRP48C, TRP48F, TRP91C, TRP91F, TYR125C, TYR125F, TYR165C, TYR98C, TYR98F, VAL118C, VAL118F, VAL299C, VAL299F, VAL315C, VAL315F, VAL40C, VAL40F, VAL47C, VAL47F, VAL83C, VAL83F, VAL97C, VAL97F
• E-F: ARG281E, GLU294F
• E-G: ALA270E, ARG298G, ARG309G, ARG316G, ASN34G, ASP271E, GLN74G, GLU302G, GLU305G, GLU313G, GLY226E, GLY266E, HIS31G, ILE228E, LYS215E, LYS218E, LYS269E, LYS2G, LYS306G, LYS317G, PHE268E, SER219E, SER224E, SER312G, THR3G, TYR33G, VAL267E, VAL310G
• E-O: ASN199E, ASN199O, ASP188E, ASP188O, ASP197E, ASP197O, ASP50E, ASP50O, GLN49E, GLN49O, GLU53E, GLU53O, GLY237E, GLY237O, ILE238O, LEU122E, LEU122O, LEU186E, LEU186O, LYS191E, LYS191O, LYS195E, LYS195O, LYS201E, LYS201O, PRO189E, PRO189O, PRO198E, PRO198O, PRO200E, PRO200O, PRO51O, SER119E, SER119O, SER185O, SER194O, SER196E, SER196O, SER224E, THR190E, THR190O, THR46E, TRP48E, TRP48O, TYR203E, TYR203O, VAL118E, VAL118O, VAL187E, VAL187O, VAL47E, VAL47O
• E-R: ALA321R, ARG164R, ARG229E, ASN162R, ASP188E, ASP231E, GLU159R, GLU167R, GLU225E, GLY166R, GLY226E, LYS163R, PHE161R, PRO189E, SER224E, THR190E, THR227E, TYR165R, TYR98R, VAL187E
• G-I: ALA321I, ARG160I, ARG164I, ARG229G, ASN162I, ASP188G, GLU159I, GLU167I, GLU225G, GLY166I, GLY226G, GLY237G, LYS163I, PHE161I, PRO189G, SER224G, THR190G, THR227G, TYR165I, TYR265G, TYR98I, VAL187G
• G-J: ALA120G, ALA120J, ALA304G, ALA304J, ALA321G, ALA321J, ALA44G, ALA44J, ALA62G, ALA62J, ALA85G, ALA85J, ALA87G, ALA87J, ALA89G, ALA89J, ALA90G, ALA90J, ARG160G, ARG160J, ARG164G, ARG164J, ARG298G, ARG298J, ARG316G, ARG316J, ARG326G, ARG326J, ARG55G, ARG55J, ARG59G, ARG59J, ASN308G, ASN308J, ASN57J, ASP297G, ASP297J, ASP301G, ASP301J, ASP41G, ASP41J, ASP50G, ASP50J, CYS95G, CYS95J, GLN320G, GLN320J, GLN42G, GLN42J, GLN49G, GLN49J, GLN56G, GLN56J, GLN80G, GLN80J, GLN88G, GLN88J, GLN94G, GLN94J, GLN9J, GLU101G, GLU101J, GLU103G, GLU103J, GLU294G, GLU294J, GLU295J, GLU302G, GLU302J, GLU305G, GLU305J, GLU319G, GLU319J, GLU53G, GLU53J, GLU82G, GLU82J, GLY100G, GLY100J, GLY121G, GLY121J, GLY303G, GLY303J, GLY323G, GLY323J, GLY325G, GLY325J, HIS43G, HIS43J, HIS52G, HIS52J, HIS86G, HIS86J, ILE39G, ILE39J, ILE45G, ILE45J, ILE58G, ILE58J, ILE79G, ILE79J, ILE96G, ILE96J, ILE99G, ILE99J, LEU102G, LEU102J, LEU122G, LEU122J, LEU123G, LEU123J, LEU128G, LEU128J, LEU296G, LEU296J, LEU300G, LEU300J, LEU324G, LEU324J, LEU54G, LEU54J, LEU77G, LEU77J, LEU93G, LEU93J, LYS317G, LYS317J, PHE161G, PHE161J, PHE78G, PHE78J, PRO126G, PRO126J, PRO127G, PRO127J, PRO51G, PRO51J, PRO84G, PRO84J, SER119G, SER119J, SER312G, SER312J, SER81G, SER81J, THR124G, THR124J, THR46G, THR46J, TRP48G, TRP48J, TRP91G, TRP91J, TYR125G, TYR125J, TYR165G, TYR165J, TYR98G, TYR98J, VAL118G, VAL118J, VAL299G, VAL299J, VAL315G, VAL315J, VAL40G, VAL40J, VAL47G, VAL47J, VAL83G, VAL83J, VAL97G, VAL97J
• G-K: ALA270G, ALA273G, ALA304K, ALA307K, ALA75K, ARG298K, ARG309K, ASN308K, ASN34K, ASP271G, ASP301K, ASP71K, CYS35K, GLN274G, GLN30K, GLN74K, GLU214G, GLU225G, GLU295K, GLU302K, GLU305K, GLU32K, GLY226G, GLY262G, GLY264G, GLY266G, GLY303K, HIS31K, ILE228G, LEU272G, LYS201G, LYS211G, LYS215G, LYS216G, LYS218G, LYS263G, LYS269G, LYS2K, LYS306K, PHE268G, PRO72K, SER219G, SER224G, THR73K, THR76K, TYR245G, TYR260G, TYR265G, TYR33K, VAL267G, VAL275G, VAL310K
• G-L: ASN199G, ASN199L, ASP188G, ASP188L, ASP197G, ASP197L, ASP50G, ASP50L, GLN49G, GLN49L, GLU53G, GLU53L, GLY237G, GLY237L, ILE238L, LEU122G, LEU122L, LEU186G, LEU186L, LYS191G, LYS191L, LYS195G, LYS195L, LYS201G, LYS201L, PRO189G, PRO189L, PRO198G, PRO198L, PRO200G, PRO200L, SER119G, SER119L, SER185G, SER194G, SER194L, SER196G, SER196L, THR190G, THR190L, THR46L, TRP48G, TRP48L, TYR203G, TYR203L, VAL118G, VAL118L, VAL187G, VAL187L, VAL47G, VAL47L
• G-O: ASP71G, GLN74G, HIS31G, HIS52O, THR73G
• G-R: ARG298G, ARG316R, GLN320R, GLU167R, GLU295G, HIS289G, TYR165R
• H-K: ALA120H, ALA120K, ALA304H, ALA304K, ALA321H, ALA321K, ALA44H, ALA44K, ALA62H, ALA62K, ALA85H, ALA85K, ALA87H, ALA87K, ALA89H, ALA89K, ALA90H, ALA90K, ARG160H, ARG160K, ARG164H, ARG164K, ARG298H, ARG298K, ARG316H, ARG316K, ARG326H, ARG326K, ARG55H, ARG55K, ARG59H, ARG59K, ASN308H, ASN308K, ASP297H, ASP297K, ASP301H, ASP301K, ASP41H, ASP41K, ASP50H, ASP50K, CYS95H, CYS95K, GLN320H, GLN320K, GLN42H, GLN42K, GLN49H, GLN49K, GLN56H, GLN56K, GLN80H, GLN80K, GLN88H, GLN88K, GLN94H, GLN94K, GLU101H, GLU101K, GLU103H, GLU103K, GLU294H, GLU294K, GLU295H, GLU295K, GLU302H, GLU302K, GLU305H, GLU305K, GLU319H, GLU319K, GLU53H, GLU53K, GLU82H, GLU82K, GLY100H, GLY100K, GLY121H, GLY121K, GLY166K, GLY303H, GLY303K, GLY323H, GLY323K, GLY325H, GLY325K, HIS43H, HIS43K, HIS52H, HIS52K, HIS86H, HIS86K, ILE39H, ILE39K, ILE45H, ILE45K, ILE58H, ILE58K, ILE79H, ILE79K, ILE96H, ILE96K, ILE99H, ILE99K, LEU102H, LEU102K, LEU122H, LEU122K, LEU123H, LEU123K, LEU128H, LEU128K, LEU157H, LEU157K, LEU296H, LEU296K, LEU300H, LEU300K, LEU324H, LEU324K, LEU54H, LEU54K, LEU77H, LEU77K, LEU93H, LEU93K, LYS163K, LYS317H, LYS317K, PHE161H, PHE161K, PHE78H, PHE78K, PRO126H, PRO126K, PRO127H, PRO127K, PRO51H, PRO51K, PRO84H, PRO84K, SER119H, SER119K, SER312K, SER81H, SER81K, THR124H, THR124K, THR46H, THR46K, TRP48H, TRP48K, TRP91H, TRP91K, TYR125H, TYR125K, TYR165H, TYR165K, TYR98H, TYR98K, VAL118H, VAL118K, VAL299H, VAL299K, VAL315H, VAL315K, VAL40H, VAL40K, VAL47H, VAL47K, VAL83H, VAL83K, VAL97H, VAL97K
• I-K: ARG298K, GLU167I, GLY166I
• I-L: ALA120I, ALA120L, ALA304I, ALA304L, ALA321I, ALA321L, ALA44I, ALA44L, ALA62I, ALA62L, ALA85I, ALA85L, ALA87I, ALA87L, ALA89I, ALA89L, ALA90I, ALA90L, ARG160I, ARG160L, ARG164I, ARG164L, ARG298I, ARG298L, ARG316I, ARG316L, ARG326I, ARG326L, ARG55I, ARG55L, ARG59I, ARG59L, ASN308I, ASN308L, ASN57I, ASN57L, ASP297I, ASP297L, ASP301I, ASP301L, ASP41I, ASP41L, ASP50I, ASP50L, CYS95I, CYS95L, GLN320I, GLN320L, GLN42I, GLN42L, GLN49I, GLN49L, GLN56I, GLN56L, GLN80I, GLN80L, GLN88I, GLN88L, GLN94I, GLN94L, GLN9L, GLU101I, GLU101L, GLU103I, GLU103L, GLU294I, GLU294L, GLU295I, GLU295L, GLU302I, GLU302L, GLU305I, GLU305L, GLU319I, GLU319L, GLU53I, GLU53L, GLU82I, GLU82L, GLY100I, GLY100L, GLY121I, GLY121L, GLY303I, GLY303L, GLY323I, GLY323L, GLY325I, GLY325L, HIS43I, HIS43L, HIS52I, HIS52L, HIS86I, HIS86L, ILE39I, ILE39L, ILE45I, ILE45L, ILE58I, ILE58L, ILE79I, ILE79L, ILE96I, ILE96L, ILE99I, ILE99L, LEU102I, LEU102L, LEU122I, LEU122L, LEU123I, LEU123L, LEU128I, LEU128L, LEU296I, LEU296L, LEU300I, LEU300L, LEU324I, LEU324L, LEU54I, LEU54L, LEU77I, LEU77L, LEU93I, LEU93L, LYS317I, LYS317L, PHE161I, PHE161L, PHE78I, PHE78L, PRO126I, PRO126L, PRO127I, PRO127L, PRO51I, PRO51L, PRO84I, PRO84L, SER119I, SER119L, SER312I, SER312L, SER81I, SER81L, THR124I, THR124L, THR46I, THR46L, TRP48I, TRP48L, TRP91I, TRP91L, TYR125I, TYR125L, TYR165I, TYR165L, TYR98I, TYR98L, VAL118I, VAL118L, VAL299I, VAL299L, VAL315I, VAL315L, VAL40I, VAL40L, VAL47I, VAL47L, VAL83I, VAL83L, VAL97I, VAL97L
• I-N: ARG160N, ARG164N, ASN162N, ASP188I, GLU159N, GLU167N, GLU225I, GLY166N, GLY226I, GLY237I, LYS163N, PHE161N, PRO189I, SER224I, THR190I, THR227I, TYR165N, TYR265I, TYR98N, VAL187I
• I-Q: ARG182Q, ASN199I, ASN199Q, ASP188I, ASP188Q, ASP197I, ASP197Q, ASP50I, ASP50Q, GLN49I, GLN49Q, GLU53I, GLU53Q, GLY237I, GLY237Q, ILE238I, ILE238Q, LEU122I, LYS191I, LYS191Q, LYS195I, LYS195Q, PRO189I, PRO189Q, PRO198I, PRO198Q, PRO200I, PRO200Q, PRO51I, SER119I, SER119Q, SER185I, SER194I, SER196I, SER196Q, SER224Q, THR190I, THR190Q, THR46I, TRP48I, TRP48Q, TYR203I, TYR203Q, VAL118I, VAL118Q, VAL187I, VAL187Q, VAL47I, VAL47Q
• J-L: ALA321J, ARG164J, ARG229L, ASN162J, ASP188L, GLU159J, GLU167J, GLU225L, GLY166J, GLY226L, GLY237L, LYS163J, PHE161J, PRO189L, SER224L, THR190L, THR227L, TYR165J, TYR265L, TYR98J, VAL187L
• K-L: ARG281K, GLU294L
• L-Q: ALA321L, ARG164L, ARG229Q, ASN162L, ASP188Q, GLU159L, GLU167L, GLU225Q, GLY166L, GLY226Q, GLY237Q, LYS163L, PHE161L, PRO189Q, SER224Q, THR190Q, THR227Q, TYR165L, TYR265Q, TYR98L, VAL187Q
• M-P: ALA120M, ALA120P, ALA304M, ALA304P, ALA321M, ALA321P, ALA44M, ALA44P, ALA62M, ALA62P, ALA85M, ALA85P, ALA87M, ALA87P, ALA89M, ALA89P, ALA90M, ALA90P, ARG160M, ARG160P, ARG164M, ARG164P, ARG298M, ARG298P, ARG316M, ARG316P, ARG326M, ARG326P, ARG55M, ARG55P, ARG59M, ARG59P, ASN308M, ASN308P, ASN57M, ASN57P, ASP297M, ASP297P, ASP301M, ASP301P, ASP41M, ASP41P, ASP50M, ASP50P, CYS95M, CYS95P, GLN320M, GLN320P, GLN42M, GLN42P, GLN49M, GLN49P, GLN56M, GLN56P, GLN80M, GLN80P, GLN88M, GLN88P, GLN94M, GLN94P, GLU101M, GLU101P, GLU103M, GLU103P, GLU294M, GLU302M, GLU302P, GLU305P, GLU319M, GLU319P, GLU53M, GLU53P, GLU82M, GLU82P, GLY100M, GLY100P, GLY121M, GLY121P, GLY303M, GLY303P, GLY323M, GLY323P, GLY325M, GLY325P, HIS43M, HIS43P, HIS52M, HIS52P, HIS86M, HIS86P, ILE39M, ILE39P, ILE45M, ILE45P, ILE58M, ILE58P, ILE79M, ILE79P, ILE96M, ILE96P, ILE99M, ILE99P, LEU102M, LEU102P, LEU122M, LEU122P, LEU123M, LEU123P, LEU128M, LEU128P, LEU296M, LEU296P, LEU300M, LEU300P, LEU324M, LEU324P, LEU54M, LEU54P, LEU77M, LEU77P, LEU93M, LEU93P, LYS163M, LYS317M, LYS317P, PHE78M, PHE78P, PRO126M, PRO126P, PRO127M, PRO127P, PRO51M, PRO51P, PRO84M, PRO84P, SER119M, SER119P, SER312M, SER312P, SER81M, SER81P, THR124M, THR124P, THR46M, THR46P, TRP48M, TRP48P, TRP91M, TRP91P, TYR125M, TYR125P, TYR165M, TYR165P, TYR98M, TYR98P, VAL118M, VAL118P, VAL299M, VAL299P, VAL315M, VAL315P, VAL40M, VAL40P, VAL47M, VAL47P, VAL83M, VAL83P, VAL97M, VAL97P
• M-Q: ALA210M, ALA270M, ALA273M, ALA304Q, ALA307Q, ALA75Q, ARG298Q, ARG309Q, ASN308Q, ASN34Q, ASP271M, ASP301Q, ASP71Q, CYS35Q, GLN259M, GLN274M, GLN30Q, GLN74Q, GLU214M, GLU261M, GLU28Q, GLU302Q, GLU305Q, GLU32Q, GLY226M, GLY262M, GLY264M, GLY266M, GLY303Q, HIS31Q, ILE228M, LEU272M, LEU29Q, LYS211M, LYS215M, LYS218M, LYS263M, LYS269M, LYS2Q, LYS306Q, PHE268M, PRO72Q, SER219M, SER224M, THR73Q, THR76Q, TYR245M, TYR260M, TYR265M, TYR33Q, TYR36Q, VAL267M, VAL275M, VAL310Q
• N-Q: ALA120N, ALA120Q, ALA304N, ALA304Q, ALA321N, ALA321Q, ALA44N, ALA44Q, ALA62N, ALA62Q, ALA85N, ALA85Q, ALA87N, ALA87Q, ALA89N, ALA89Q, ALA90N, ALA90Q, ARG160N, ARG160Q, ARG164N, ARG164Q, ARG298N, ARG298Q, ARG316N, ARG316Q, ARG326N, ARG326Q, ARG55N, ARG55Q, ARG59N, ARG59Q, ASN308N, ASN308Q, ASN57N, ASN57Q, ASP297N, ASP297Q, ASP301N, ASP301Q, ASP41N, ASP41Q, ASP50N, ASP50Q, CYS95N, CYS95Q, GLN320N, GLN320Q, GLN42N, GLN42Q, GLN49N, GLN49Q, GLN56N, GLN56Q, GLN80N, GLN80Q, GLN88N, GLN88Q, GLN94N, GLN94Q, GLU101N, GLU101Q, GLU103N, GLU103Q, GLU294N, GLU294Q, GLU295N, GLU295Q, GLU302N, GLU302Q, GLU305N, GLU305Q, GLU319N, GLU319Q, GLU53N, GLU53Q, GLU82N, GLU82Q, GLY100N, GLY100Q, GLY121N, GLY121Q, GLY303N, GLY303Q, GLY323N, GLY323Q, GLY325N, GLY325Q, HIS43N, HIS43Q, HIS52N, HIS52Q, HIS86N, HIS86Q, ILE39N, ILE39Q, ILE45N, ILE45Q, ILE58N, ILE58Q, ILE79N, ILE79Q, ILE96N, ILE96Q, ILE99N, ILE99Q, LEU102N, LEU102Q, LEU122N, LEU122Q, LEU123N, LEU123Q, LEU128N, LEU128Q, LEU157N, LEU157Q, LEU296N, LEU296Q, LEU300N, LEU300Q, LEU324N, LEU324Q, LEU54N, LEU54Q, LEU77N, LEU93N, LEU93Q, LYS317N, LYS317Q, PHE161N, PHE161Q, PHE78N, PHE78Q, PRO126N, PRO126Q, PRO127N, PRO127Q, PRO51N, PRO51Q, PRO84N, PRO84Q, SER119N, SER119Q, SER312N, SER312Q, SER81N, SER81Q, THR124N, THR124Q, THR46N, THR46Q, TRP48N, TRP48Q, TRP91N, TRP91Q, TYR125N, TYR125Q, TYR165N, TYR165Q, TYR98N, TYR98Q, VAL118N, VAL118Q, VAL299N, VAL299Q, VAL315N, VAL315Q, VAL40N, VAL40Q, VAL47N, VAL47Q, VAL83N, VAL83Q, VAL97N, VAL97Q
• O-R: ALA120O, ALA120R, ALA304O, ALA304R, ALA321O, ALA321R, ALA44O, ALA44R, ALA62O, ALA62R, ALA85O, ALA85R, ALA87O, ALA87R, ALA89O, ALA89R, ALA90O, ALA90R, ARG160O, ARG160R, ARG164O, ARG164R, ARG298O, ARG298R, ARG316O, ARG316R, ARG326O, ARG326R, ARG55O, ARG55R, ARG59O, ARG59R, ASN308O, ASN308R, ASN57O, ASP297O, ASP297R, ASP301O, ASP301R, ASP41O, ASP41R, ASP50O, ASP50R, CYS95O, CYS95R, GLN320O, GLN320R, GLN42O, GLN42R, GLN49O, GLN49R, GLN56O, GLN56R, GLN80O, GLN80R, GLN88O, GLN88R, GLN94O, GLN94R, GLU101O, GLU101R, GLU103O, GLU103R, GLU294O, GLU294R, GLU295R, GLU302O, GLU302R, GLU319O, GLU319R, GLU53O, GLU53R, GLU82O, GLU82R, GLY100O, GLY100R, GLY121O, GLY121R, GLY303O, GLY303R, GLY323O, GLY323R, GLY325O, GLY325R, HIS43O, HIS43R, HIS52O, HIS52R, HIS86O, HIS86R, ILE39O, ILE39R, ILE45O, ILE45R, ILE58O, ILE58R, ILE79O, ILE79R, ILE96O, ILE96R, ILE99O, ILE99R, LEU102O, LEU102R, LEU122O, LEU122R, LEU123O, LEU123R, LEU128O, LEU128R, LEU157O, LEU296O, LEU296R, LEU300O, LEU300R, LEU324O, LEU324R, LEU54O, LEU54R, LEU77R, LEU93O, LEU93R, LYS317O, LYS317R, PHE161O, PHE161R, PHE78O, PHE78R, PRO126O, PRO126R, PRO127O, PRO127R, PRO51O, PRO51R, PRO84O, PRO84R, SER119O, SER119R, SER312R, SER81O, SER81R, THR124O, THR124R, THR46O, THR46R, TRP48O, TRP48R, TRP91O, TRP91R, TYR125O, TYR125R, TYR165O, TYR165R, TYR98O, TYR98R, VAL118O, VAL118R, VAL299O, VAL299R, VAL315O, VAL315R, VAL40O, VAL40R, VAL47O, VAL47R, VAL83O, VAL83R, VAL97O, VAL97R