3FFK

crystal structure of human gelsolin domains g1-g3 bound to actin

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 195
  • Norm. En. per Res.: -4.3573
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-162.1105	-122.1893	-565.374	-849.6738	195	38	10	21395	11	79	71
A-E	-18.0046	0.9142	-48.1274	-65.2178	31	3	0	1661	0	11	12
B-E	0.0	0.0	-0.0723	-0.0723	2	0	0	5	0	2	5
D-E	-127.2829	-84.2906	-542.555	-754.1285	193	29	10	20874	9	67	65

Interface residues

• A-B: ALA100A, ALA101A, ALA102A, ALA116A, ALA144B, ALA19B, ALA229A, ALA22B, ALA26B, ALA295B, ALA29B, ALA323A, ALA347B, ALA58B, ALA97B, ARG115A, ARG120A, ARG147B, ARG221A, ARG225A, ARG228A, ARG230A, ARG28B, ARG328A, ARG335B, ARG370A, ARG95B, ASN128B, ASN155A, ASN223A, ASN296B, ASN324A, ASN92B, ASP109A, ASP110A, ASP222A, ASP24B, ASP25B, ASP292B, ASP371A, ASP373A, ASP3B, ASP50A, ASP51B, ASP56B, ASP96A, GLN107A, GLN118A, GLN322A, GLN353B, GLN354B, GLN374A, GLN49B, GLN59B, GLN95A, GLU100B, GLU121A, GLU156A, GLU167B, GLU224A, GLU28A, GLU31A, GLU334B, GLU355A, GLU358A, GLU47A, GLU4B, GLU57B, GLU93B, GLU97A, GLU99B, GLY114A, GLY146B, GLY148A, GLY168B, GLY20B, GLY219A, GLY227A, GLY23B, GLY320A, GLY342B, GLY343B, GLY356A, GLY357A, GLY55B, GLY99A, HIS101B, HIS119A, HIS151A, HIS29A, HIS87B, HIS88B, ILE103A, ILE165B, ILE220A, ILE330B, ILE341B, ILE345B, LEU108A, LEU140B, LEU142B, LEU16B, LEU332A, LEU33A, LEU346B, LEU349B, LEU353A, LEU51A, LEU85A, LEU89A, LEU94B, LYS150A, LYS18B, LYS218A, LYS319A, LYS321A, LYS328B, LYS329A, LYS336B, LYS363A, LYS48A, LYS50B, LYS61B, LYS84B, MET355B, PHE104A, PHE127B, PHE149A, PHE21B, PHE31B, PHE32A, PHE352B, PHE362A, PHE49A, PHE90B, PRO130B, PRO154A, PRO27B, PRO30A, PRO32B, PRO332B, PRO333B, PRO354A, PRO360A, PRO372A, PRO98B, SER141B, SER145B, SER147A, SER226A, SER338B, SER344B, SER348B, SER350B, SER351A, SER52B, SER60B, SER94A, SER98A, THR105A, THR126B, THR148B, THR149B, THR325A, THR351B, THR359A, THR5B, THR6B, THR89B, TRP340B, TYR111A, TYR133B, TYR143B, TYR166B, TYR169B, TYR337B, TYR53B, TYR87A, TYR91B, VAL106A, VAL117A, VAL122A, VAL139B, VAL152A, VAL153A, VAL157A, VAL17B, VAL231A, VAL298B, VAL30B, VAL352A, VAL46A, VAL52A, VAL54B, VAL96B
• A-E: ALA365E, ARG37E, ARG45A, ASN57A, ASP337A, ASP363E, GLN121E, GLN360E, GLU125E, GLU361E, GLU364E, GLU47A, GLY366E, ILE369E, LEU58A, LEU65E, LYS333A, LYS34A, LYS359E, LYS68E, PRO367E, PRO38E, PRO53A, PRO55A, SER368E, THR56A, THR66E, TYR362E, TYR59A, VAL52A, VAL54A
• B-E: ASP80E, GLU4B
• D-E: ALA100D, ALA101D, ALA102D, ALA116D, ALA144E, ALA19E, ALA229D, ALA22E, ALA26E, ALA295E, ALA29E, ALA323D, ALA347E, ALA58E, ALA97E, ARG115D, ARG120D, ARG147E, ARG221D, ARG225D, ARG228D, ARG230D, ARG28E, ARG328D, ARG335E, ARG370D, ARG62E, ARG95E, ASN128E, ASN155D, ASN223D, ASN296E, ASN324D, ASN92E, ASP109D, ASP110D, ASP222D, ASP24E, ASP25E, ASP292E, ASP371D, ASP50D, ASP51E, ASP56E, ASP96D, CYS304D, GLN107D, GLN118D, GLN322D, GLN353E, GLN354E, GLN59E, GLN95D, GLU100E, GLU121D, GLU156D, GLU167E, GLU224D, GLU28D, GLU31D, GLU334E, GLU355D, GLU358D, GLU47D, GLU57E, GLU93E, GLU97D, GLU99E, GLY114D, GLY146E, GLY148D, GLY168E, GLY20E, GLY219D, GLY227D, GLY23E, GLY320D, GLY342E, GLY343E, GLY356D, GLY357D, GLY55E, GLY99D, HIS101E, HIS119D, HIS151D, HIS29D, HIS87E, HIS88E, ILE103D, ILE165E, ILE220D, ILE289E, ILE330E, ILE341E, ILE345E, LEU108D, LEU140E, LEU142E, LEU16E, LEU332D, LEU346E, LEU349E, LEU353D, LEU361D, LEU51D, LEU85D, LEU89D, LEU94E, LYS150D, LYS18E, LYS218D, LYS319D, LYS321D, LYS328E, LYS329D, LYS336E, LYS363D, LYS48D, LYS50E, LYS61E, LYS84E, MET355E, PHE104D, PHE127E, PHE149D, PHE21E, PHE31E, PHE32D, PHE352E, PHE362D, PHE49D, PHE90E, PRO154D, PRO27E, PRO30D, PRO32E, PRO332E, PRO333E, PRO354D, PRO360D, PRO372D, PRO98E, SER141E, SER145E, SER147D, SER226D, SER338E, SER344E, SER348E, SER350E, SER351D, SER52E, SER60E, SER94D, SER98D, THR105D, THR126E, THR148E, THR149E, THR325D, THR351E, THR359D, THR5E, THR89E, TRP340E, TRP369D, TYR111D, TYR133E, TYR143E, TYR166E, TYR169E, TYR337E, TYR53E, TYR87D, TYR91E, VAL106D, VAL117D, VAL122D, VAL139E, VAL152D, VAL153D, VAL157D, VAL17E, VAL27D, VAL298E, VAL30E, VAL339E, VAL352D, VAL46D, VAL52D, VAL54E, VAL96E