3FFD

structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-P
  • Int. Res.: 47
  • Norm. En. per Res.: -4.9666
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-23.4847	-28.1695	-459.419	-511.0732	179	14	12	18308	7	19	21
A-P	-24.7364	0.0	-166.948	-191.6844	42	5	1	5580	0	1	0
B-P	-57.514	-68.8239	-107.094	-233.4319	47	10	1	4156	8	19	15

Interface residues

• A-B: ALA106A, ALA130A, ALA139B, ALA173A, ALA182B, ALA218A, ALA49A, ALA88B, ALA97A, ARG38A, ARG44A, ARG98A, ASN137B, ASN147B, ASN172B, ASP169B, ASP42A, ASP49B, ASP60B, ASP62A, ASP96B, CYS143B, CYS145A, CYS92B, CYS96A, GLN101B, GLN110A, GLN176A, GLN37B, GLN38B, GLN39A, GLN39B, GLN6B, GLU100B, GLU132B, GLU133B, GLU136B, GLU176B, GLU216A, GLU34B, GLU46A, GLU6A, GLY107B, GLY108B, GLY109A, GLY109B, GLY111A, GLY144A, GLY149A, GLY167B, GLY177B, GLY59B, GLY93B, GLY95B, HIS169A, HIS187B, ILE145B, ILE215A, ILE33B, ILE37A, ILE91B, ILE98B, LEU129A, LEU134B, LEU141B, LEU143A, LEU144B, LEU146A, LEU175A, LEU182A, LEU186B, LEU188B, LEU214B, LEU2B, LEU41B, LEU45A, LEU4B, LEU50B, LYS111B, LYS135B, LYS138B, LYS148A, LYS175B, LYS179B, LYS212B, LYS213A, LYS214A, LYS42B, LYS43A, LYS45B, LYS51B, LYS65A, LYS99B, MET102A, MET181B, MET48B, MET89B, MET93A, PHE102B, PHE105A, PHE106B, PHE127B, PHE148B, PHE171A, PHE180B, PHE185B, PRO128A, PRO128B, PRO129B, PRO131A, PRO172A, PRO173B, PRO217A, PRO40B, PRO41A, PRO43B, PRO44B, PRO61A, SER125A, SER130B, SER131B, SER146B, SER171B, SER177A, SER183A, SER183B, SER184A, SER184B, SER185A, SER35A, SER57B, THR100A, THR103A, THR123B, THR125B, THR140B, THR142A, THR170A, THR170B, THR174B, THR181A, THR187A, THR32B, THR50A, THR58A, THR58B, THR5B, THR97B, TRP108A, TRP159A, TRP35B, TRP36A, TRP47A, TYR104A, TYR104B, TYR107A, TYR127A, TYR36B, TYR46B, TYR57A, TYR59A, TYR60A, TYR90B, TYR95A, VAL103B, VAL105B, VAL126A, VAL126B, VAL141A, VAL142B, VAL147A, VAL168A, VAL168B, VAL174A, VAL186A, VAL3B, VAL47B, VAL48A, VAL94B
• A-P: ALA106A, ALA29P, ARG19P, ARG20P, ARG21P, ARG72A, ARG98A, ASN74A, ASP17P, GLN16P, GLN99A, GLU30P, GLY33A, GLY54A, GLY55A, HIS25P, HIS26P, ILE28P, ILE31P, ILE51A, LEU24P, LEU27P, MET102A, MET34A, PHE105A, PHE23P, SER30A, SER31A, SER35A, SER52A, SER53A, SER56A, THR100A, THR101A, THR103A, THR50A, THR58A, TRP47A, TYR104A, TYR32A, TYR57A, TYR59A
• B-P: ARG19P, ARG20P, ARG21P, ARG75B, ASP17P, ASP49B, ASP53B, ASP96B, GLN101B, GLN16P, GLN27B, GLN52B, GLU100B, GLU34B, GLY93B, GLY95B, HIS26P, HIS28B, ILE15P, ILE33B, ILE98B, LEU18P, LEU24B, LEU24P, LEU27P, LEU2B, LEU4B, LEU50B, LYS51B, LYS99B, MET48B, PHE102B, PHE22P, PHE23P, SER14P, SER29B, SER57B, THR30B, THR32B, THR97B, TRP35B, TYR104B, TYR31B, TYR36B, TYR46B, VAL103B, VAL94B