3FA4

crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, triclinic crystal form

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 228
  • Norm. En. per Res.: -4.154
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-101.0725	4.5203	-798.642	-895.1942	238	31	40	33477	0	37	41
A-C	-39.5468	-39.0967	-269.711	-348.3545	128	5	6	10208	9	21	18
A-D	-24.0126	28.8953	-103.863	-98.9804	67	18	3	5052	0	8	6
A-K	0.0	0.0	-0.0054	-0.0054	6	0	0	5	0	5	5
A-L	0.0	-5.6627	-1.6576	-7.3204	6	0	0	190	0	5	7
B-C	-7.3826	30.3999	-115.838	-92.8207	73	21	4	5685	0	16	12
B-D	-67.1083	-46.8583	-301.948	-415.9146	138	22	6	11674	10	22	17
B-F	-9.4417	4.4204	-36.7739	-41.7952	37	3	0	1581	0	17	17
B-G	0.0	12.0949	-0.0286	12.0664	4	0	0	4	0	0	4
B-K	0.0	11.5923	-3.1509	8.4414	12	0	0	340	0	14	13
B-L	0.0	0.0	-0.0021	-0.0021	3	0	0	6	0	3	5
C-D	-138.4506	10.1807	-844.567	-972.8369	238	27	37	33922	0	38	44
C-G	-7.596	-1.198	-34.381	-43.1749	32	0	0	1349	0	17	15
E-F	-135.8744	5.1162	-813.47	-944.2282	241	34	37	33473	0	40	40
E-G	-46.116	-44.7928	-287.431	-378.3399	133	8	6	11032	10	20	19
E-H	-20.795	27.7123	-89.3263	-82.4089	57	18	3	4550	0	8	6
F-G	-17.9524	27.7933	-101.036	-91.1951	67	16	4	5319	0	10	9
F-H	-52.5865	-46.9975	-289.518	-389.102	130	10	6	10938	11	20	18
F-K	-8.2958	-12.9816	-77.7618	-99.0392	47	5	0	3202	3	25	23
F-L	0.0	-7.2953	-0.0426	-7.338	5	0	0	29	0	3	4
G-H	-112.3252	13.7581	-818.276	-916.8431	226	27	37	33561	0	36	38
H-K	0.0	0.0	-0.0191	-0.0191	5	0	0	3	0	0	0
I-J	-139.3928	8.2313	-815.947	-947.1085	228	36	40	33610	0	37	39
I-K	-33.4986	-45.4535	-241.833	-320.785	118	8	7	9300	10	23	18
I-L	-9.2968	27.157	-110.759	-92.8987	77	21	4	5629	0	12	10
J-K	-15.6585	30.0622	-83.7763	-69.3726	51	13	4	4211	0	7	6
J-L	-75.6476	-45.4583	-238.678	-359.7838	113	13	6	9237	10	20	19
K-L	-125.253	4.873	-867.309	-987.6891	244	27	40	34667	1	39	43

Interface residues

• A-B: ALA220A, ALA220B, ALA226A, ALA226B, ALA227A, ALA227B, ALA229A, ALA229B, ALA23A, ALA23B, ALA242A, ALA242B, ALA243A, ALA243B, ALA247A, ALA247B, ALA249A, ALA249B, ALA250A, ALA250B, ALA254A, ALA254B, ALA294B, ALA295B, ALA32A, ALA32B, ALA35A, ALA35B, ALA38A, ALA38B, ALA42A, ALA48A, ALA48B, ALA51A, ALA51B, ALA52A, ALA52B, ALA58A, ALA58B, ALA70A, ALA70B, ARG196A, ARG196B, ARG252A, ARG252B, ARG260A, ARG260B, ARG277A, ARG277B, ARG33A, ARG33B, ASN214A, ASN214B, ASN71A, ASN71B, ASN77A, ASN77B, ASP261A, ASP261B, ASP267A, ASP267B, ASP282A, ASP282B, ASP288A, ASP288B, ASP28A, ASP28B, ASP41A, ASP41B, ASP59A, ASP59B, CYS279A, CYS279B, GLN273A, GLN273B, GLN57A, GLN57B, GLU191B, GLU217A, GLU217B, GLU228A, GLU228B, GLU253A, GLU253B, GLU256A, GLU256B, GLU269A, GLU269B, GLU283A, GLU283B, GLY129A, GLY219A, GLY219B, GLY245A, GLY245B, GLY25A, GLY25B, GLY262A, GLY262B, GLY265A, GLY265B, GLY280A, GLY280B, GLY29A, GLY29B, GLY39A, GLY39B, GLY47A, GLY47B, GLY49A, GLY49B, GLY56A, GLY56B, HIS218A, HIS218B, HIS55A, HIS55B, ILE131A, ILE224A, ILE224B, ILE237A, ILE237B, ILE238A, ILE238B, ILE263A, ILE263B, ILE62A, ILE62B, ILE75A, ILE75B, ILE78A, ILE78B, LEU213A, LEU213B, LEU244A, LEU244B, LEU258A, LEU258B, LEU266A, LEU266B, LEU275A, LEU275B, LEU281A, LEU281B, LEU30A, LEU30B, LEU36A, LEU36B, LEU43A, LEU43B, LEU60A, LEU60B, LYS122B, LYS130A, LYS257A, LYS257B, LYS259A, LYS259B, LYS268A, LYS268B, MET215A, MET215B, MET251A, MET251B, MET255A, MET255B, MET270A, MET270B, MET274A, MET274B, MET285A, MET285B, MET74A, MET74B, PHE20A, PHE20B, PHE239A, PHE239B, PHE241A, PHE241B, PHE276A, PHE276B, PHE296B, PHE40A, PHE40B, PRO222A, PRO222B, PRO240A, PRO240B, PRO246A, PRO246B, PRO24A, PRO24B, PRO264A, PRO264B, PRO272A, PRO272B, SER223A, SER223B, SER225A, SER225B, SER284A, SER284B, SER31A, SER31B, SER37A, SER37B, SER53A, SER53B, THR121A, THR221A, THR221B, THR271A, THR271B, THR46A, THR46B, THR50A, THR50B, TYR27A, TYR27B, TYR44B, VAL119A, VAL216A, VAL216B, VAL22A, VAL22B, VAL248A, VAL248B, VAL26A, VAL26B, VAL278A, VAL278B, VAL287A, VAL287B, VAL34A, VAL34B, VAL54A, VAL54B
• A-C: ALA144A, ALA144C, ALA145A, ALA145C, ALA148A, ALA148C, ALA183A, ALA183C, ALA289A, ALA289C, ALA291A, ALA291C, ALA70A, ALA70C, ALA7A, ALA7C, ALA99A, ALA99C, ARG100A, ARG100C, ARG107A, ARG107C, ARG11C, ARG12C, ARG141A, ARG141C, ARG143A, ARG143C, ARG149A, ARG149C, ARG151A, ARG151C, ARG33A, ARG33C, ARG69A, ARG69C, ASN66A, ASN66C, ASN77A, ASN77C, ASP136A, ASP136C, ASP155A, ASP155C, ASP288A, ASP288C, GLN104A, GLN104C, GLN147A, GLN147C, GLN150C, GLN290A, GLN290C, GLU103A, GLU103C, GLU283A, GLU283C, GLU73A, GLU73C, GLY109A, GLY109C, GLY153A, GLY153C, GLY280C, GLY292A, GLY292C, GLY94A, GLY94C, ILE142A, ILE142C, ILE152A, ILE152C, ILE156A, ILE156C, ILE78A, ILE78C, ILE96A, ILE96C, LEU281A, LEU281C, LYS286A, LYS286C, MET285A, MET285C, MET3A, MET3C, MET74A, MET74C, MET97A, MET97C, PRO2A, PRO80A, PRO80C, PRO95A, PRO95C, SER106A, SER106C, SER108A, SER108C, SER154A, SER154C, SER284A, SER284C, SER76A, SER76C, THR102A, THR102C, THR137A, THR137C, THR140A, THR140C, THR5A, THR5C, THR8A, THR8C, TYR105A, TYR105C, VAL110A, VAL110C, VAL139A, VAL139C, VAL146A, VAL287A, VAL287C, VAL4A, VAL4C, VAL98A, VAL98C
• A-D: ALA51A, ALA51D, ALA58A, ALA58D, ALA70A, ALA70D, ALA99A, ARG100A, ARG100D, ARG141A, ARG141D, ASN66A, ASN66D, ASP67A, ASP67D, CYS63A, CYS63D, GLN104A, GLN104D, GLN120A, GLN120D, GLN57A, GLN57D, GLU103A, GLU103D, GLY56A, GLY56D, GLY61A, GLY61D, GLY93A, GLY93D, GLY94A, GLY94D, HIS55A, HIS55D, ILE62A, ILE62D, ILE96A, ILE96D, LEU60A, LEU60D, LEU65A, LEU65D, MET68A, MET68D, MET97A, MET97D, PRO95A, PRO95D, THR121A, THR121D, THR137A, THR137D, THR64A, THR64D, THR90A, THR90D, TYR92A, TYR92D, VAL119A, VAL119D, VAL133A, VAL133D, VAL54A, VAL54D, VAL98A, VAL98D
• A-K: ALA38A, GLN290K, GLY293K, GLY39A, LYS230A, LYS286K
• A-L: ARG252L, ARG260L, GLU253L, GLU256L, GLU269A, LYS268A
• B-C: ALA51B, ALA51C, ALA58B, ALA58C, ALA70B, ALA70C, ALA99B, ALA99C, ARG100B, ARG100C, ARG123C, ARG141B, ARG141C, ASN66B, ASN66C, ASP67B, ASP67C, CYS63B, CYS63C, GLN104B, GLN104C, GLN120B, GLN120C, GLN57B, GLN57C, GLU103B, GLU103C, GLY56B, GLY56C, GLY61B, GLY61C, GLY93B, GLY93C, GLY94B, GLY94C, HIS55B, HIS55C, ILE62B, ILE62C, ILE96B, ILE96C, LEU60B, LEU60C, LEU65B, LEU65C, LYS122B, LYS122C, MET68B, MET68C, MET97B, MET97C, PRO95B, PRO95C, THR121B, THR121C, THR137B, THR137C, THR140B, THR140C, THR64B, THR64C, THR90B, THR90C, TYR92B, TYR92C, VAL119B, VAL119C, VAL133B, VAL133C, VAL54B, VAL54C, VAL98B, VAL98C
• B-D: ALA144B, ALA144D, ALA145B, ALA145D, ALA148B, ALA148D, ALA183B, ALA183D, ALA289B, ALA289D, ALA291B, ALA291D, ALA294B, ALA295B, ALA70B, ALA70D, ALA7B, ALA7D, ALA99B, ALA99D, ARG100B, ARG100D, ARG107B, ARG107D, ARG11B, ARG12D, ARG141B, ARG141D, ARG143B, ARG143D, ARG149B, ARG149D, ARG151B, ARG151D, ARG33B, ARG33D, ARG69B, ARG69D, ASN66B, ASN66D, ASN77B, ASN77D, ASP136B, ASP136D, ASP155B, ASP155D, ASP282B, ASP282D, ASP288B, ASP288D, GLN104B, GLN104D, GLN147B, GLN147D, GLN150D, GLN290B, GLN290D, GLU103B, GLU103D, GLU283B, GLU283D, GLU73B, GLU73D, GLY109B, GLY109D, GLY153B, GLY153D, GLY280B, GLY280D, GLY292B, GLY292D, GLY293B, GLY293D, GLY94B, GLY94D, ILE142B, ILE142D, ILE152B, ILE152D, ILE156B, ILE156D, ILE78B, ILE78D, ILE96B, ILE96D, LEU281B, LEU281D, LYS286B, LYS286D, MET285B, MET285D, MET3B, MET3D, MET74B, MET74D, MET97B, MET97D, PHE296B, PRO2B, PRO2D, PRO80B, PRO80D, PRO95B, PRO95D, SER106B, SER106D, SER108B, SER108D, SER154B, SER154D, SER284B, SER284D, SER76B, SER76D, THR102B, THR102D, THR137B, THR137D, THR140B, THR140D, THR5B, THR5D, THR8B, THR8D, TYR105B, TYR105D, VAL110B, VAL110D, VAL139B, VAL139D, VAL146B, VAL146D, VAL287B, VAL287D, VAL4B, VAL4D, VAL98B, VAL98D
• B-F: ALA220B, ARG176F, ARG196B, ASP134F, GLN166B, GLN166F, GLN201B, GLU171B, GLU171F, GLU172B, GLU172F, GLU197B, GLY129F, GLY169B, GLY169F, HIS168B, HIS168F, ILE131F, LEU132F, LEU165B, LEU165F, LYS130F, MET198B, MET198F, PRO222B, SER164B, SER164F, SER173B, SER195B, THR135F, THR167B, THR167F, THR194B, TYR170B, TYR170F, VAL133F, VAL174B
• B-G: ASP134B, ASP134G, ASP136B, ASP136G
• B-K: ALA289K, ARG260B, ASP282K, GLN290K, GLU253B, GLU256B, GLY293K, LEU281K, LYS257B, LYS259B, LYS286K, MET285K
• B-L: ARG260B, GLY125L, LEU127L
• C-D: ALA220C, ALA220D, ALA226C, ALA226D, ALA227C, ALA227D, ALA229C, ALA229D, ALA23C, ALA23D, ALA242C, ALA242D, ALA243C, ALA243D, ALA247C, ALA247D, ALA249C, ALA249D, ALA250C, ALA250D, ALA254C, ALA254D, ALA289D, ALA291D, ALA32C, ALA32D, ALA35C, ALA35D, ALA38C, ALA38D, ALA42C, ALA42D, ALA48C, ALA48D, ALA51C, ALA51D, ALA52C, ALA52D, ALA58C, ALA58D, ALA70C, ALA70D, ARG123C, ARG196C, ARG196D, ARG252C, ARG252D, ARG260C, ARG260D, ARG277C, ARG277D, ARG33C, ARG33D, ASN214C, ASN214D, ASN71C, ASN71D, ASN77C, ASN77D, ASP261C, ASP261D, ASP267C, ASP267D, ASP282C, ASP282D, ASP288C, ASP288D, ASP28C, ASP28D, ASP41C, ASP41D, ASP59C, ASP59D, ASP67C, ASP67D, CYS279C, CYS279D, GLN273C, GLN273D, GLN57C, GLN57D, GLU191D, GLU217C, GLU217D, GLU228C, GLU228D, GLU253C, GLU253D, GLU256C, GLU256D, GLU269C, GLU269D, GLU283C, GLU283D, GLY219C, GLY219D, GLY245C, GLY245D, GLY25C, GLY25D, GLY262C, GLY262D, GLY265C, GLY265D, GLY280C, GLY280D, GLY292D, GLY29C, GLY29D, GLY39C, GLY39D, GLY47C, GLY47D, GLY49C, GLY49D, GLY56C, GLY56D, HIS218C, HIS218D, HIS55C, HIS55D, ILE224C, ILE224D, ILE237C, ILE237D, ILE238C, ILE238D, ILE263C, ILE263D, ILE62C, ILE62D, ILE75C, ILE75D, ILE78C, ILE78D, LEU213C, LEU213D, LEU244C, LEU244D, LEU258C, LEU258D, LEU266C, LEU266D, LEU275C, LEU275D, LEU281C, LEU281D, LEU30C, LEU30D, LEU36C, LEU36D, LEU43C, LEU43D, LEU60C, LEU60D, LYS122C, LYS257C, LYS257D, LYS259C, LYS259D, LYS268C, LYS268D, MET215C, MET215D, MET251C, MET251D, MET255C, MET255D, MET270C, MET270D, MET274C, MET274D, MET285C, MET285D, MET74C, MET74D, PHE20C, PHE20D, PHE239C, PHE239D, PHE241C, PHE241D, PHE276C, PHE276D, PHE40C, PHE40D, PRO222C, PRO222D, PRO240C, PRO240D, PRO246C, PRO246D, PRO24C, PRO24D, PRO264C, PRO264D, PRO272C, PRO272D, SER223C, SER223D, SER225C, SER225D, SER284C, SER284D, SER31C, SER31D, SER37C, SER37D, SER53C, SER53D, THR221C, THR221D, THR271C, THR271D, THR46C, THR46D, THR50C, THR50D, TYR27C, TYR27D, TYR44C, TYR44D, VAL216C, VAL216D, VAL22C, VAL22D, VAL248C, VAL248D, VAL26C, VAL26D, VAL278C, VAL278D, VAL287C, VAL287D, VAL34C, VAL34D, VAL54C, VAL54D
• C-G: ARG176C, ASP134C, GLN166C, GLN166G, GLU171C, GLU171G, GLU172C, GLU172G, GLU197G, GLY169C, GLY169G, HIS168C, HIS168G, ILE131C, LEU132C, LEU165C, LEU165G, LYS130C, MET198C, MET198G, SER164C, SER164G, SER173G, SER195G, THR135C, THR167C, THR167G, THR194G, TYR170C, TYR170G, VAL133C, VAL174G
• E-F: ALA220E, ALA220F, ALA226E, ALA226F, ALA227E, ALA227F, ALA229E, ALA229F, ALA23E, ALA23F, ALA242E, ALA242F, ALA243E, ALA243F, ALA247E, ALA247F, ALA249E, ALA249F, ALA250E, ALA250F, ALA254E, ALA254F, ALA294E, ALA32E, ALA32F, ALA35E, ALA35F, ALA38E, ALA38F, ALA42E, ALA42F, ALA48E, ALA48F, ALA51E, ALA51F, ALA52E, ALA52F, ALA58E, ALA58F, ALA70E, ALA70F, ARG196E, ARG196F, ARG252E, ARG252F, ARG260E, ARG260F, ARG277E, ARG277F, ARG33E, ARG33F, ASN214E, ASN214F, ASN71E, ASN71F, ASN77F, ASP261E, ASP261F, ASP267E, ASP267F, ASP282E, ASP282F, ASP288E, ASP288F, ASP28E, ASP28F, ASP41E, ASP41F, ASP59E, ASP59F, ASP67E, ASP67F, CYS279E, CYS279F, GLN166E, GLN273E, GLN273F, GLN57E, GLN57F, GLU191E, GLU217E, GLU217F, GLU228E, GLU228F, GLU253E, GLU253F, GLU256E, GLU256F, GLU269E, GLU269F, GLU283E, GLU283F, GLY129E, GLY129F, GLY219E, GLY219F, GLY245E, GLY245F, GLY25E, GLY25F, GLY262E, GLY262F, GLY265E, GLY265F, GLY280E, GLY280F, GLY292E, GLY293E, GLY29E, GLY29F, GLY39E, GLY39F, GLY47E, GLY47F, GLY49E, GLY49F, GLY56E, GLY56F, HIS218E, HIS218F, HIS55E, HIS55F, ILE131F, ILE224E, ILE224F, ILE237E, ILE237F, ILE238E, ILE238F, ILE263E, ILE263F, ILE62E, ILE62F, ILE75E, ILE75F, ILE78E, ILE78F, LEU213E, LEU213F, LEU244E, LEU244F, LEU258E, LEU258F, LEU266E, LEU266F, LEU275E, LEU275F, LEU281E, LEU281F, LEU30E, LEU30F, LEU36E, LEU36F, LEU43E, LEU43F, LEU60E, LEU60F, LYS122F, LYS257E, LYS257F, LYS259E, LYS259F, LYS268E, LYS268F, MET215E, MET215F, MET251E, MET251F, MET255E, MET255F, MET270E, MET270F, MET274E, MET274F, MET285E, MET285F, MET74E, MET74F, PHE20E, PHE20F, PHE239E, PHE239F, PHE241E, PHE241F, PHE276E, PHE276F, PHE40E, PHE40F, PRO222E, PRO222F, PRO240E, PRO240F, PRO246E, PRO246F, PRO24E, PRO24F, PRO264E, PRO264F, PRO272E, PRO272F, SER223E, SER223F, SER225E, SER225F, SER284E, SER284F, SER31E, SER31F, SER37E, SER37F, SER53E, SER53F, THR121F, THR221E, THR221F, THR271E, THR271F, THR46E, THR46F, THR50E, THR50F, TYR27E, TYR27F, TYR44E, TYR44F, VAL216E, VAL216F, VAL22E, VAL22F, VAL248E, VAL248F, VAL26E, VAL26F, VAL278E, VAL278F, VAL287E, VAL287F, VAL34E, VAL34F, VAL54E, VAL54F
• E-G: ALA144E, ALA144G, ALA145E, ALA145G, ALA148E, ALA148G, ALA183E, ALA183G, ALA289E, ALA289G, ALA291E, ALA291G, ALA294E, ALA70E, ALA70G, ALA7E, ALA7G, ALA99E, ALA99G, ARG100E, ARG100G, ARG107E, ARG107G, ARG11E, ARG12E, ARG12G, ARG141E, ARG141G, ARG143E, ARG143G, ARG149E, ARG149G, ARG151E, ARG151G, ARG33E, ARG33G, ARG69E, ARG69G, ASN66E, ASN66G, ASN77E, ASN77G, ASP136E, ASP136G, ASP155E, ASP155G, ASP282E, ASP288E, ASP288G, GLN104E, GLN104G, GLN147E, GLN147G, GLN150E, GLN290E, GLN290G, GLU103E, GLU103G, GLU283E, GLU283G, GLU73E, GLU73G, GLY109E, GLY109G, GLY153E, GLY153G, GLY280E, GLY292E, GLY292G, GLY293E, GLY94E, GLY94G, ILE142E, ILE142G, ILE152E, ILE152G, ILE156E, ILE156G, ILE78E, ILE78G, ILE96E, ILE96G, LEU281E, LEU281G, LYS286E, LYS286G, MET285E, MET285G, MET3E, MET3G, MET74E, MET74G, MET97E, MET97G, PRO2E, PRO2G, PRO80E, PRO80G, PRO95E, PRO95G, SER106E, SER106G, SER108E, SER108G, SER154E, SER154G, SER284E, SER284G, SER76E, SER76G, THR102E, THR102G, THR137E, THR137G, THR140E, THR140G, THR5E, THR5G, THR8E, THR8G, TYR105E, TYR105G, VAL110E, VAL110G, VAL139E, VAL139G, VAL146E, VAL287E, VAL287G, VAL4E, VAL4G, VAL98E, VAL98G
• E-H: ALA51E, ALA51H, ALA58E, ALA58H, ALA70E, ALA70H, ALA99E, ARG100E, ARG100H, ARG141H, ASN66E, ASN66H, ASP67E, ASP67H, CYS63E, CYS63H, GLN104E, GLN104H, GLN120E, GLN120H, GLN57E, GLN57H, GLU103E, GLY56E, GLY56H, GLY61E, GLY61H, GLY93E, GLY93H, GLY94E, GLY94H, HIS55E, HIS55H, ILE62E, ILE62H, ILE96E, ILE96H, LEU60E, LEU60H, LEU65E, LEU65H, MET68E, MET68H, MET97E, MET97H, PRO95H, THR121E, THR137H, THR64E, THR64H, THR90H, TYR92E, TYR92H, VAL119H, VAL54E, VAL54H, VAL98E
• F-G: ALA51F, ALA51G, ALA58F, ALA58G, ALA70F, ALA70G, ALA99F, ARG100F, ARG100G, ARG141F, ARG141G, ASN66F, ASN66G, ASP67F, ASP67G, CYS63F, CYS63G, GLN104F, GLN104G, GLN120F, GLN120G, GLN57F, GLN57G, GLU103F, GLY56F, GLY56G, GLY61F, GLY61G, GLY91G, GLY93F, GLY93G, GLY94F, GLY94G, HIS55F, HIS55G, ILE62F, ILE62G, ILE96F, ILE96G, LEU60F, LEU60G, LEU65F, LEU65G, LYS122F, MET68F, MET68G, MET97F, MET97G, PRO95F, PRO95G, THR121F, THR121G, THR137F, THR137G, THR140G, THR64F, THR64G, THR90F, THR90G, TYR92F, TYR92G, VAL133F, VAL133G, VAL54F, VAL54G, VAL98F, VAL98G
• F-H: ALA111F, ALA144F, ALA144H, ALA145F, ALA145H, ALA148F, ALA148H, ALA183F, ALA183H, ALA289F, ALA289H, ALA291F, ALA291H, ALA70F, ALA70H, ALA7F, ALA7H, ALA99F, ALA99H, ARG100F, ARG100H, ARG107F, ARG107H, ARG11F, ARG11H, ARG12F, ARG12H, ARG141F, ARG141H, ARG143F, ARG143H, ARG149F, ARG149H, ARG151F, ARG151H, ARG33F, ARG33H, ARG69F, ARG69H, ASN66F, ASN66H, ASN77F, ASN77H, ASP136F, ASP136H, ASP155F, ASP155H, ASP282F, ASP288F, ASP288H, GLN104F, GLN104H, GLN147F, GLN147H, GLN290F, GLN290H, GLU103F, GLU103H, GLU283F, GLU283H, GLU73F, GLU73H, GLY109F, GLY109H, GLY153F, GLY153H, GLY280F, GLY292F, GLY292H, GLY94F, GLY94H, ILE142F, ILE142H, ILE152F, ILE152H, ILE156F, ILE156H, ILE78F, ILE78H, ILE96F, ILE96H, LEU281F, LEU281H, LYS286F, LYS286H, MET285F, MET285H, MET3F, MET3H, MET74F, MET74H, MET97F, MET97H, PRO2F, PRO2H, PRO80F, PRO80H, PRO95F, PRO95H, SER106F, SER106H, SER108F, SER108H, SER154F, SER154H, SER284F, SER284H, SER76F, SER76H, THR102F, THR137F, THR137H, THR140F, THR140H, THR5F, THR5H, THR8F, THR8H, TYR105F, TYR105H, VAL110F, VAL110H, VAL139F, VAL139H, VAL287F, VAL287H, VAL4F, VAL4H, VAL98F, VAL98H
• F-K: ALA179F, ALA180F, ALA183F, ALA185F, ALA199K, ALA207F, ALA226K, ALA227K, ALA229K, ARG11F, ARG143F, ARG149F, ARG178F, ARG181F, ARG196K, ARG200K, ASP155F, ASP182F, ASP186F, GLN147F, GLN150F, GLN201K, GLN204K, GLU15F, GLU197K, GLU228K, GLU231K, GLY184F, GLY208F, ILE142F, ILE203K, ILE224K, LEU177F, LYS230K, MET232K, PRO210F, PRO222K, SER154F, SER195K, SER223K, SER225K, THR140F, TRP209F, VAL139F, VAL146F, VAL158F, VAL187F
• F-L: ARG178F, ARG181F, ASP182F, ASP261L, ILE263L
• G-H: ALA220H, ALA226G, ALA226H, ALA227G, ALA227H, ALA229G, ALA229H, ALA23G, ALA23H, ALA242G, ALA242H, ALA243G, ALA243H, ALA247G, ALA247H, ALA249G, ALA249H, ALA250G, ALA250H, ALA254G, ALA254H, ALA32G, ALA32H, ALA35G, ALA35H, ALA38G, ALA38H, ALA42G, ALA48G, ALA48H, ALA51G, ALA51H, ALA52G, ALA52H, ALA58G, ALA58H, ALA70G, ALA70H, ARG196G, ARG196H, ARG252G, ARG252H, ARG260G, ARG260H, ARG277G, ARG277H, ARG33G, ARG33H, ASN214G, ASN71G, ASN71H, ASN77G, ASP261G, ASP261H, ASP267G, ASP267H, ASP282G, ASP282H, ASP288G, ASP288H, ASP28G, ASP28H, ASP41G, ASP41H, ASP59G, ASP59H, ASP67G, CYS279G, CYS279H, GLN273G, GLN273H, GLN57G, GLN57H, GLU217G, GLU217H, GLU228G, GLU228H, GLU253G, GLU253H, GLU256G, GLU256H, GLU269G, GLU269H, GLU283G, GLU283H, GLY219G, GLY219H, GLY245G, GLY245H, GLY25G, GLY25H, GLY262G, GLY262H, GLY265G, GLY265H, GLY280G, GLY280H, GLY29G, GLY29H, GLY39G, GLY39H, GLY47G, GLY47H, GLY49G, GLY49H, GLY56G, GLY56H, HIS218G, HIS218H, HIS55G, HIS55H, ILE224G, ILE224H, ILE237G, ILE237H, ILE238G, ILE238H, ILE263G, ILE263H, ILE62G, ILE62H, ILE75G, ILE75H, ILE78G, ILE78H, LEU213G, LEU213H, LEU244G, LEU244H, LEU258G, LEU258H, LEU266G, LEU266H, LEU275G, LEU275H, LEU281G, LEU281H, LEU30G, LEU30H, LEU36G, LEU36H, LEU43G, LEU43H, LEU60G, LEU60H, LYS257G, LYS257H, LYS259G, LYS259H, LYS268G, LYS268H, MET215G, MET215H, MET251G, MET251H, MET255G, MET255H, MET270G, MET270H, MET274G, MET274H, MET285G, MET285H, MET74G, MET74H, PHE20G, PHE20H, PHE239G, PHE239H, PHE241G, PHE241H, PHE276G, PHE276H, PHE40G, PHE40H, PRO222G, PRO222H, PRO240G, PRO240H, PRO246G, PRO246H, PRO24G, PRO24H, PRO264G, PRO264H, PRO272G, PRO272H, SER223G, SER223H, SER225G, SER225H, SER284G, SER284H, SER31G, SER31H, SER37G, SER37H, SER53G, SER53H, THR221H, THR271G, THR271H, THR46G, THR46H, THR50G, THR50H, TYR27G, TYR27H, TYR44G, TYR44H, VAL216G, VAL216H, VAL22G, VAL22H, VAL248G, VAL248H, VAL26G, VAL26H, VAL278G, VAL278H, VAL287G, VAL287H, VAL34G, VAL34H, VAL54G, VAL54H
• H-K: ALA291H, GLN290H, GLU197K, GLU231K, PRO2H
• I-J: ALA226I, ALA226J, ALA227I, ALA227J, ALA229I, ALA229J, ALA23I, ALA23J, ALA242I, ALA242J, ALA243I, ALA243J, ALA247I, ALA247J, ALA249I, ALA249J, ALA250I, ALA250J, ALA254I, ALA254J, ALA32I, ALA32J, ALA35I, ALA35J, ALA38I, ALA38J, ALA42I, ALA48I, ALA48J, ALA51I, ALA51J, ALA52I, ALA52J, ALA58I, ALA58J, ALA70I, ALA70J, ARG196I, ARG196J, ARG252I, ARG252J, ARG260I, ARG260J, ARG277I, ARG277J, ARG33I, ARG33J, ASN214I, ASN214J, ASN71I, ASN71J, ASN77I, ASN77J, ASP261I, ASP261J, ASP267I, ASP267J, ASP282I, ASP282J, ASP288I, ASP288J, ASP28I, ASP28J, ASP41I, ASP41J, ASP59I, ASP59J, ASP67I, CYS279I, CYS279J, GLN273I, GLN273J, GLN57I, GLN57J, GLU191I, GLU217I, GLU217J, GLU228I, GLU228J, GLU253I, GLU253J, GLU256I, GLU256J, GLU269I, GLU269J, GLU283I, GLU283J, GLY219I, GLY219J, GLY245I, GLY245J, GLY25I, GLY25J, GLY262I, GLY262J, GLY265I, GLY265J, GLY280I, GLY280J, GLY29I, GLY29J, GLY39I, GLY39J, GLY47I, GLY47J, GLY49I, GLY49J, GLY56I, GLY56J, HIS218I, HIS218J, HIS55I, HIS55J, ILE224I, ILE224J, ILE237I, ILE237J, ILE238I, ILE238J, ILE263I, ILE263J, ILE62I, ILE62J, ILE75I, ILE75J, ILE78I, ILE78J, LEU213I, LEU213J, LEU244I, LEU244J, LEU258I, LEU258J, LEU266I, LEU266J, LEU275I, LEU275J, LEU281I, LEU281J, LEU30I, LEU30J, LEU36I, LEU36J, LEU43I, LEU43J, LEU60I, LEU60J, LYS257I, LYS257J, LYS259I, LYS259J, LYS268I, LYS268J, MET215I, MET215J, MET251I, MET251J, MET255I, MET255J, MET270I, MET270J, MET274I, MET274J, MET285I, MET285J, MET74I, MET74J, PHE20I, PHE20J, PHE239I, PHE239J, PHE241I, PHE241J, PHE276I, PHE276J, PHE40I, PHE40J, PRO222I, PRO222J, PRO240I, PRO240J, PRO246I, PRO246J, PRO24I, PRO24J, PRO264I, PRO264J, PRO272I, PRO272J, SER223I, SER223J, SER225I, SER225J, SER284I, SER284J, SER31I, SER31J, SER37I, SER37J, SER53I, SER53J, THR221I, THR221J, THR271I, THR271J, THR46I, THR46J, THR50I, THR50J, TYR27I, TYR27J, TYR44J, VAL216I, VAL216J, VAL22I, VAL22J, VAL248I, VAL248J, VAL26I, VAL26J, VAL278I, VAL278J, VAL287I, VAL287J, VAL34I, VAL34J, VAL54I, VAL54J
• I-K: ALA144I, ALA144K, ALA145I, ALA145K, ALA148I, ALA148K, ALA183I, ALA183K, ALA289I, ALA289K, ALA291I, ALA291K, ALA70I, ALA70K, ALA7K, ALA99I, ALA99K, ARG100I, ARG100K, ARG107I, ARG107K, ARG141I, ARG141K, ARG143I, ARG143K, ARG149K, ARG151I, ARG151K, ARG33I, ARG33K, ARG69I, ARG69K, ASN66I, ASN66K, ASN77I, ASN77K, ASP136I, ASP136K, ASP155K, ASP288I, ASP288K, GLN104I, GLN104K, GLN147I, GLN147K, GLN150K, GLN290I, GLN290K, GLU103I, GLU103K, GLU283I, GLU283K, GLU73I, GLU73K, GLY109I, GLY109K, GLY153I, GLY153K, GLY292I, GLY292K, GLY293K, GLY94I, GLY94K, ILE142I, ILE142K, ILE152I, ILE152K, ILE156K, ILE78I, ILE78K, ILE96I, ILE96K, LEU281I, LEU281K, LYS286I, LYS286K, MET285I, MET285K, MET3I, MET74I, MET74K, MET97I, MET97K, PRO80I, PRO80K, PRO95I, PRO95K, SER106I, SER106K, SER108I, SER108K, SER154I, SER154K, SER284I, SER284K, SER76I, SER76K, THR102K, THR137I, THR137K, THR140I, THR140K, THR5I, THR5K, THR8K, TYR105K, VAL110I, VAL110K, VAL139I, VAL139K, VAL146I, VAL146K, VAL287I, VAL287K, VAL4I, VAL4K, VAL98I, VAL98K
• I-L: ALA144I, ALA51I, ALA51L, ALA58I, ALA58L, ALA70I, ALA70L, ARG100I, ARG100L, ARG123L, ARG141I, ARG141L, ARG143I, ASN66I, ASN66L, ASP134I, ASP136I, ASP67I, ASP67L, CYS124L, CYS63I, CYS63L, GLN104I, GLN104L, GLN120I, GLN120L, GLN57I, GLN57L, GLY125L, GLY56I, GLY56L, GLY61I, GLY61L, GLY91I, GLY91L, GLY93I, GLY93L, GLY94I, GLY94L, HIS126L, HIS55I, HIS55L, ILE62I, ILE62L, ILE96I, ILE96L, LEU127L, LEU60I, LEU60L, LEU65I, LEU65L, LYS122L, MET68I, MET68L, MET97I, MET97L, PRO95I, PRO95L, THR121I, THR121L, THR137I, THR137L, THR140I, THR64I, THR64L, THR90I, THR90L, TYR92I, TYR92L, VAL119I, VAL119L, VAL133I, VAL133L, VAL54I, VAL54L, VAL98I, VAL98L
• J-K: ALA51J, ALA51K, ALA58J, ALA58K, ALA70J, ALA70K, ALA99J, ARG100J, ARG100K, ASN66J, ASN66K, ASP67J, ASP67K, CYS63J, CYS63K, GLN104J, GLN104K, GLN120J, GLN120K, GLN57J, GLN57K, GLU103J, GLY56J, GLY56K, GLY61J, GLY61K, GLY93J, GLY93K, GLY94J, GLY94K, HIS55J, HIS55K, ILE62J, ILE62K, ILE96J, ILE96K, LEU60J, LEU60K, LEU65J, LEU65K, MET68J, MET68K, MET97J, MET97K, THR64J, THR64K, THR90J, TYR92J, TYR92K, VAL54J, VAL54K
• J-L: ALA144J, ALA144L, ALA145J, ALA145L, ALA148J, ALA148L, ALA183J, ALA183L, ALA289J, ALA289L, ALA291J, ALA291L, ALA70J, ALA70L, ALA7L, ALA99J, ALA99L, ARG100J, ARG100L, ARG107J, ARG107L, ARG141J, ARG141L, ARG143J, ARG143L, ARG149L, ARG151J, ARG151L, ARG33J, ARG69J, ARG69L, ASN66J, ASN66L, ASN77J, ASN77L, ASP136J, ASP136L, ASP155L, ASP288J, ASP288L, GLN104J, GLN104L, GLN147J, GLN147L, GLN290J, GLN290L, GLU103J, GLU103L, GLU283J, GLU283L, GLU73J, GLU73L, GLY109J, GLY109L, GLY153L, GLY280L, GLY292J, GLY292L, GLY94J, GLY94L, ILE142J, ILE142L, ILE152J, ILE152L, ILE156L, ILE78J, ILE78L, ILE96J, ILE96L, LEU281J, LEU281L, LYS286J, LYS286L, MET285J, MET285L, MET3J, MET74J, MET74L, MET97J, MET97L, PRO80J, PRO80L, PRO95J, PRO95L, SER106J, SER106L, SER108J, SER108L, SER154L, SER284J, SER284L, SER76J, SER76L, THR102L, THR137J, THR137L, THR140J, THR140L, THR5J, THR5L, THR8L, TYR105J, TYR105L, VAL110J, VAL110L, VAL139J, VAL139L, VAL146J, VAL287J, VAL287L, VAL4J, VAL98J, VAL98L
• K-L: ALA128L, ALA220K, ALA226K, ALA226L, ALA227K, ALA227L, ALA229K, ALA229L, ALA23K, ALA23L, ALA242K, ALA242L, ALA243K, ALA243L, ALA247K, ALA247L, ALA249K, ALA249L, ALA250K, ALA250L, ALA254K, ALA254L, ALA289K, ALA291K, ALA32K, ALA32L, ALA35K, ALA35L, ALA38K, ALA38L, ALA42K, ALA42L, ALA48K, ALA48L, ALA51K, ALA51L, ALA52K, ALA52L, ALA58K, ALA58L, ALA70K, ALA70L, ARG123L, ARG196L, ARG252K, ARG252L, ARG260K, ARG260L, ARG277K, ARG277L, ARG33K, ARG33L, ASN214K, ASN214L, ASN71K, ASN71L, ASN77K, ASN77L, ASP261K, ASP261L, ASP267K, ASP267L, ASP282K, ASP282L, ASP288K, ASP288L, ASP28K, ASP28L, ASP41K, ASP41L, ASP59K, ASP59L, ASP67L, CYS124L, CYS279K, CYS279L, GLN273K, GLN273L, GLN290K, GLN57K, GLN57L, GLU191K, GLU217K, GLU217L, GLU228K, GLU228L, GLU253K, GLU253L, GLU256K, GLU256L, GLU269K, GLU269L, GLU283K, GLU283L, GLY125L, GLY129L, GLY219K, GLY219L, GLY245K, GLY245L, GLY25K, GLY25L, GLY262K, GLY262L, GLY265K, GLY265L, GLY280K, GLY280L, GLY292K, GLY293K, GLY29K, GLY29L, GLY39K, GLY39L, GLY47K, GLY47L, GLY49K, GLY49L, GLY56K, GLY56L, HIS126L, HIS218K, HIS218L, HIS55K, HIS55L, ILE224K, ILE224L, ILE237K, ILE237L, ILE238K, ILE238L, ILE263K, ILE263L, ILE62K, ILE62L, ILE75K, ILE75L, ILE78K, ILE78L, LEU127L, LEU213K, LEU213L, LEU244K, LEU244L, LEU258K, LEU258L, LEU266K, LEU266L, LEU275K, LEU275L, LEU281K, LEU281L, LEU30K, LEU30L, LEU36K, LEU36L, LEU43K, LEU43L, LEU60K, LEU60L, LYS122L, LYS130L, LYS257K, LYS257L, LYS259K, LYS259L, LYS268K, LYS268L, LYS286K, MET215K, MET215L, MET251K, MET251L, MET255K, MET255L, MET270K, MET270L, MET274K, MET274L, MET285K, MET285L, MET74K, MET74L, PHE20K, PHE20L, PHE239K, PHE239L, PHE241K, PHE241L, PHE276K, PHE276L, PHE40K, PHE40L, PRO222K, PRO222L, PRO240K, PRO240L, PRO246K, PRO246L, PRO24K, PRO24L, PRO264K, PRO264L, PRO272K, PRO272L, SER223K, SER223L, SER225K, SER225L, SER284K, SER284L, SER31K, SER31L, SER37K, SER37L, SER53K, SER53L, THR221K, THR271K, THR271L, THR46K, THR46L, THR50K, THR50L, TYR27K, TYR27L, TYR44K, TYR44L, VAL216K, VAL216L, VAL22K, VAL22L, VAL248K, VAL248L, VAL26K, VAL26L, VAL278K, VAL278L, VAL287K, VAL287L, VAL34K, VAL34L, VAL54K, VAL54L