3F3P

crystal structure of the nucleoporin pair nup85-seh1, space group p21212

• Total interactions analyzed: 66
• Total true interactions: 21
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 254
  • Norm. En. per Res.: -4.1057
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-145.1167	-52.1856	-845.539	-1042.8413	254	49	28	34161	6	55	60
A-D	-22.071	-50.8079	-174.626	-247.5049	92	5	3	7484	7	34	30
B-C	-16.7867	-48.9396	-175.515	-241.2414	93	4	3	7460	7	34	31
B-D	-98.5756	-50.2555	-814.384	-963.2152	245	36	26	33755	5	58	58
B-E	-17.7018	-97.6664	-174.556	-289.9242	79	19	0	7050	4	58	89
B-G	0.0	0.0	-0.0135	-0.0135	2	0	0	7	0	1	1
C-D	-19.5557	70.4266	-220.285	-169.4142	105	8	4	8638	0	23	30
D-E	0.0	0.0	-0.002	-0.002	3	0	0	2	0	2	1
E-G	-118.8008	-33.5532	-820.556	-972.91	252	38	24	34242	4	58	60
E-H	-35.4608	-47.5352	-185.22	-268.2159	93	5	3	7867	7	34	31
F-G	-30.637	-46.909	-176.375	-253.9211	92	3	3	7425	7	34	31
F-H	-71.3943	-27.653	-816.501	-915.5482	252	29	24	34143	4	58	59
F-I	-6.8607	-88.3024	-174.447	-269.6101	80	17	0	7051	4	57	87
F-K	0.0	0.0	-0.0273	-0.0273	2	0	0	10	0	2	1
G-H	-17.6376	36.067	-223.605	-205.1756	110	17	4	9162	2	29	41
H-I	0.0	0.0	-0.0144	-0.0144	2	0	0	8	0	1	1
I-K	-120.6396	-46.4315	-846.244	-1013.3151	248	28	28	34265	4	61	64
I-L	-38.9821	-50.0897	-186.72	-275.7918	95	6	3	7775	7	34	32
J-K	-29.7633	-47.062	-167.579	-244.4043	90	4	3	7209	7	34	30
J-L	-127.0251	-36.2285	-844.303	-1007.5566	246	51	26	33930	3	57	62
K-L	-20.801	71.4009	-222.98	-172.3801	110	10	4	8779	0	24	30

Interface residues

• A-C: ALA119A, ALA25A, ALA322A, ALA333A, ALA347A, ALA462C, ALA46C, ALA470C, ALA499C, ALA505C, ALA535C, ALA60A, ALA80C, ALA84C, ARG177A, ARG216A, ARG226A, ARG22A, ARG329A, ARG40C, ARG458C, ARG70A, ARG94C, ARG97C, ASN304A, ASN313A, ASN337A, ASN432C, ASN44A, ASN459C, ASN467C, ASN544C, ASN54C, ASN61C, ASN78C, ASP10A, ASP14A, ASP168A, ASP18A, ASP302A, ASP30A, ASP324A, ASP325A, ASP39A, ASP41C, ASP453C, ASP55C, ASP5A, ASP62A, ASP63C, ASP86C, ASP87A, ASP89A, ASP9A, CYS27A, CYS341A, CYS474C, GLN229A, GLN2A, GLN348A, GLN349A, GLN545C, GLN56C, GLN77C, GLU247A, GLU306A, GLU410C, GLU431C, GLU452C, GLU472C, GLU506C, GLU533C, GLU537C, GLU59C, GLU67A, GLU85A, GLU86A, GLY122A, GLY21A, GLY225A, GLY305A, GLY316A, GLY323A, GLY326A, GLY45C, GLY460C, GLY477C, GLY543C, GLY62C, GLY69A, GLY72C, GLY7A, HIS120A, HIS13A, HIS23A, HIS303A, HIS510C, HIS8A, ILE224A, ILE318A, ILE345A, ILE430C, ILE433C, ILE47C, ILE489C, ILE504C, ILE534C, ILE538C, ILE58C, ILE61A, ILE71A, ILE82C, ILE95C, LEU11A, LEU123A, LEU145A, LEU230A, LEU314A, LEU319A, LEU330A, LEU38A, LEU406C, LEU451C, LEU454C, LEU473C, LEU476C, LEU48C, LEU507C, LEU508C, LEU531C, LEU542C, LEU547C, LEU67C, LEU71C, LEU74C, LEU90C, LEU98C, LYS115A, LYS244A, LYS248A, LYS327A, LYS332A, LYS340A, LYS34A, LYS40A, LYS500C, LYS501C, LYS536C, LYS60C, LYS64C, LYS68C, LYS70C, LYS85C, LYS87C, LYS89C, PHE178A, PHE19A, PHE339A, PHE36A, PHE434C, PHE455C, PHE469C, PHE471C, PHE4A, PHE513C, PHE69C, PHE81C, PRO118A, PRO142A, PRO175A, PRO180A, PRO222A, PRO3A, PRO407C, PRO42C, PRO509C, PRO50C, PRO512C, PRO57C, PRO66A, PRO66C, PRO73C, PRO88A, PRO92C, PRO96C, SER176A, SER179A, SER217A, SER219A, SER223A, SER28A, SER29A, SER309A, SER311A, SER320A, SER321A, SER336A, SER343A, SER414C, SER43A, SER44C, SER456C, SER463C, SER468C, SER475C, SER498C, SER65A, SER6A, SER75C, THR246A, THR26A, THR315A, THR317A, THR334A, THR346A, THR52C, THR540C, THR541C, THR83C, TRP227A, TRP308A, TRP312A, TRP331A, TRP45A, TRP482C, TRP63A, TYR17A, TYR20A, TYR228A, TYR335A, TYR457C, TYR464C, TYR511C, TYR539C, TYR68A, TYR76C, TYR77A, TYR88C, TYR91C, VAL12A, VAL15A, VAL16A, VAL24A, VAL307A, VAL310A, VAL328A, VAL344A, VAL43C, VAL49C, VAL503C, VAL514C, VAL53C, VAL59A, VAL93C
• A-D: ALA191A, ALA205A, ALA206A, ALA316D, ALA333A, ALA372D, ARG239A, ARG241A, ARG304D, ARG329D, ARG344D, ASN291A, ASN308D, ASN337A, ASN342D, ASP301A, ASP302A, ASP330D, ASP334D, GLN190A, GLN293A, GLN315D, GLN343D, GLN348D, GLN376D, GLU247A, GLU295A, GLU299A, GLU305D, GLU327D, GLU333D, GLU338A, GLU369D, GLU373D, GLU380D, GLY210A, GLY318D, GLY326D, GLY340D, GLY341D, HIS211A, HIS300A, ILE192A, ILE193A, ILE240A, ILE245A, ILE346D, ILE365D, LEU208A, LEU292A, LEU296A, LEU297A, LEU309D, LEU311D, LEU313D, LEU337D, LEU347D, LEU368D, LEU370D, LYS207A, LYS212A, LYS244A, LYS248A, LYS307D, LYS312D, LYS340A, LYS345D, PHE243A, PHE303D, PHE317D, PHE339A, PHE360D, PRO209A, SER298A, SER301D, SER314D, SER319D, SER320D, SER336A, SER367D, SER371D, THR246A, THR302D, THR334A, TRP227A, TRP306D, TYR331D, TYR335A, TYR364D, TYR374D, VAL294A, VAL310D
• B-C: ALA191B, ALA205B, ALA206B, ALA316C, ALA333B, ALA372C, ARG239B, ARG241B, ARG304C, ARG329C, ARG344C, ASN291B, ASN308C, ASN337B, ASN342C, ASP301B, ASP302B, ASP330C, ASP334C, GLN190B, GLN293B, GLN315C, GLN343C, GLN348C, GLN376C, GLU247B, GLU295B, GLU299B, GLU305C, GLU327C, GLU333C, GLU338B, GLU369C, GLU373C, GLU380C, GLY210B, GLY318C, GLY326C, GLY340C, GLY341C, HIS211B, HIS300B, ILE192B, ILE193B, ILE245B, ILE365C, LEU208B, LEU292B, LEU296B, LEU297B, LEU309C, LEU311C, LEU313C, LEU337C, LEU347C, LEU368C, LEU370C, LYS207B, LYS212B, LYS244B, LYS248B, LYS307C, LYS312C, LYS340B, LYS345C, PHE243B, PHE303C, PHE317C, PHE339B, PHE360C, PRO209B, SER290B, SER298B, SER300C, SER301C, SER314C, SER319C, SER320C, SER336B, SER367C, SER371C, THR246B, THR302C, THR334B, TRP227B, TRP306C, TYR331C, TYR335B, TYR364C, TYR374C, VAL204B, VAL294B, VAL310C
• B-D: ALA119B, ALA25B, ALA322B, ALA333B, ALA347B, ALA462D, ALA46D, ALA470D, ALA499D, ALA505D, ALA535D, ALA549D, ALA60B, ALA80D, ALA84D, ARG177B, ARG216B, ARG226B, ARG22B, ARG329B, ARG458D, ARG70B, ARG94D, ARG97B, ARG97D, ASN304B, ASN313B, ASN337B, ASN432D, ASN44B, ASN459D, ASN467D, ASN544D, ASN54D, ASN61D, ASN78D, ASP10B, ASP14B, ASP168B, ASP18B, ASP302B, ASP30B, ASP324B, ASP325B, ASP453D, ASP55D, ASP5B, ASP62B, ASP63D, ASP86D, ASP87B, ASP89B, ASP9B, CYS27B, CYS341B, CYS474D, GLN2B, GLN348B, GLN349B, GLN545D, GLN56D, GLN77D, GLU247B, GLU306B, GLU338B, GLU410D, GLU452D, GLU472D, GLU506D, GLU533D, GLU537D, GLU59D, GLU67B, GLU85B, GLU86B, GLY21B, GLY225B, GLY305B, GLY316B, GLY323B, GLY326B, GLY45D, GLY460D, GLY477D, GLY543D, GLY62D, GLY69B, GLY72D, GLY7B, HIS120B, HIS13B, HIS23B, HIS303B, HIS510D, HIS550D, HIS8B, ILE224B, ILE318B, ILE345B, ILE433D, ILE47D, ILE489D, ILE504D, ILE534D, ILE538D, ILE58D, ILE61B, ILE71B, ILE82D, ILE95D, LEU11B, LEU145B, LEU230B, LEU314B, LEU319B, LEU330B, LEU38B, LEU451D, LEU454D, LEU473D, LEU476D, LEU48D, LEU507D, LEU508D, LEU531D, LEU542D, LEU547D, LEU67D, LEU71D, LEU74D, LEU90D, LEU98D, LYS115B, LYS244B, LYS327B, LYS332B, LYS340B, LYS34B, LYS40B, LYS500D, LYS501D, LYS536D, LYS60D, LYS64D, LYS68D, LYS70D, LYS85D, LYS87D, LYS89D, PHE178B, PHE19B, PHE339B, PHE36B, PHE434D, PHE455D, PHE469D, PHE471D, PHE4B, PHE513D, PHE69D, PHE81D, PRO118B, PRO175B, PRO180B, PRO222B, PRO3B, PRO407D, PRO509D, PRO50D, PRO512D, PRO57D, PRO66B, PRO66D, PRO73D, PRO88B, PRO92D, PRO96D, SER176B, SER179B, SER217B, SER219B, SER223B, SER28B, SER29B, SER309B, SER311B, SER320B, SER321B, SER336B, SER343B, SER414D, SER43B, SER44D, SER456D, SER463D, SER468D, SER475D, SER498D, SER548D, SER65B, SER6B, SER75D, THR246B, THR26B, THR315B, THR317B, THR334B, THR346B, THR52D, THR540D, THR541D, THR83D, TRP227B, TRP308B, TRP312B, TRP331B, TRP45B, TRP482D, TYR17B, TYR20B, TYR228B, TYR335B, TYR457D, TYR464D, TYR511D, TYR539D, TYR68B, TYR76D, TYR77B, TYR88D, TYR91D, VAL12B, VAL15B, VAL16B, VAL24B, VAL307B, VAL310B, VAL328B, VAL344B, VAL49D, VAL503D, VAL514D, VAL53D, VAL59B, VAL93D
• B-E: ALA53B, ALA53E, ARG146B, ARG146E, ARG52B, ARG52E, ARG96B, ARG96E, ARG97B, ARG97E, ASN99B, ASN99E, ASP10B, ASP10E, ASP30B, ASP30E, ASP49B, ASP49E, ASP55B, ASP55E, ASP78B, ASP78E, ASP87B, ASP87E, ASP9B, ASP9E, CYS102B, CYS102E, CYS93B, CYS93E, GLN31B, GLN31E, GLN90B, GLN90E, GLU85B, GLU85E, GLU91B, GLU91E, GLY95B, GLY95E, HIS32B, HIS32E, HIS54B, HIS54E, HIS8B, HIS8E, LEU101B, LEU101E, LEU11B, LEU11E, LEU83E, LYS100B, LYS100E, LYS79B, LYS79E, LYS82B, LYS82E, SER28B, SER28E, SER29B, SER29E, SER50B, SER50E, SER56B, SER56E, SER57B, SER57E, SER94B, SER94E, THR103B, THR103E, THR80B, THR80E, TRP51B, TRP51E, TRP84B, TRP84E, TRP98B, TRP98E
• B-G: ARG96B, TYR88G
• C-D: ALA372C, ALA372D, ALA462C, ALA462D, ARG304C, ARG304D, ARG458C, ARG458D, ASN200C, ASN200D, ASN432C, ASN432D, ASN459C, ASN459D, ASP193C, ASP193D, ASP196C, ASP196D, ASP396C, ASP396D, GLN195C, GLN195D, GLN376C, GLN376D, GLN392C, GLN392D, GLU198C, GLU198D, GLU199C, GLU199D, GLU369C, GLU369D, GLU373C, GLU373D, GLU431C, GLU431D, GLU435C, GLU435D, GLU452D, GLY194C, GLY194D, GLY400C, GLY400D, GLY460C, GLY460D, HIS403C, HIS403D, ILE365C, ILE365D, ILE397C, ILE397D, ILE398C, ILE398D, ILE402C, ILE402D, ILE430C, ILE430D, ILE433C, ILE433D, LEU192C, LEU192D, LEU368C, LEU368D, LEU370C, LEU370D, LEU375C, LEU375D, LEU379C, LEU379D, LYS401C, LYS401D, PHE434C, PHE434D, PRO366C, PRO366D, PRO407C, PRO407D, SER300C, SER300D, SER367C, SER367D, SER371C, SER371D, SER399C, SER399D, SER404C, SER404D, SER456C, SER456D, TYR189C, TYR189D, TYR364C, TYR364D, TYR374C, TYR374D, TYR457C, TYR457D, TYR464C, TYR464D, VAL197C, VAL197D, VAL395C, VAL395D, VAL408C, VAL408D
• D-E: ARG96E, LYS85D, TYR88D
• E-G: ALA119E, ALA25E, ALA322E, ALA333E, ALA347E, ALA462G, ALA46G, ALA470G, ALA499G, ALA505G, ALA535G, ALA60E, ALA80G, ALA84G, ARG177E, ARG216E, ARG226E, ARG22E, ARG329E, ARG40G, ARG458G, ARG70E, ARG94G, ARG97E, ARG97G, ASN304E, ASN313E, ASN337E, ASN432G, ASN44E, ASN459G, ASN467G, ASN544G, ASN54G, ASN61G, ASN78G, ASP10E, ASP14E, ASP168E, ASP18E, ASP302E, ASP30E, ASP324E, ASP325E, ASP39E, ASP41G, ASP453G, ASP55G, ASP5E, ASP62E, ASP63G, ASP86G, ASP87E, ASP89E, ASP9E, CYS27E, CYS341E, CYS474G, GLN229E, GLN2E, GLN348E, GLN349E, GLN545G, GLN56G, GLN77G, GLU247E, GLU306E, GLU338E, GLU410G, GLU437G, GLU452G, GLU472G, GLU506G, GLU533G, GLU537G, GLU59G, GLU67E, GLU85E, GLU86E, GLY21E, GLY225E, GLY305E, GLY316E, GLY323E, GLY326E, GLY45G, GLY460G, GLY477G, GLY543G, GLY62G, GLY69E, GLY72G, GLY7E, HIS120E, HIS13E, HIS23E, HIS300E, HIS303E, HIS510G, HIS8E, ILE224E, ILE318E, ILE345E, ILE433G, ILE47G, ILE489G, ILE504G, ILE534G, ILE538G, ILE58G, ILE61E, ILE71E, ILE82G, ILE95G, LEU11E, LEU145E, LEU230E, LEU314E, LEU319E, LEU330E, LEU38E, LEU451G, LEU454G, LEU473G, LEU476G, LEU48G, LEU507G, LEU508G, LEU531G, LEU542G, LEU547G, LEU67G, LEU71G, LEU74G, LEU90G, LEU98G, LYS115E, LYS244E, LYS248E, LYS327E, LYS332E, LYS340E, LYS34E, LYS39G, LYS40E, LYS500G, LYS501G, LYS536G, LYS60G, LYS64G, LYS68G, LYS70G, LYS85G, LYS87G, LYS89G, PHE178E, PHE19E, PHE36E, PHE434G, PHE455G, PHE469G, PHE471G, PHE4E, PHE513G, PHE69G, PHE81G, PRO118E, PRO175E, PRO180E, PRO222E, PRO3E, PRO407G, PRO42G, PRO509G, PRO50G, PRO512G, PRO57G, PRO66E, PRO66G, PRO73G, PRO88E, PRO92G, PRO96G, SER176E, SER179E, SER217E, SER219E, SER223E, SER28E, SER29E, SER309E, SER311E, SER320E, SER321E, SER336E, SER343E, SER414G, SER43E, SER44G, SER456G, SER463G, SER468G, SER475G, SER498G, SER548G, SER65E, SER6E, SER75G, THR246E, THR26E, THR315E, THR317E, THR334E, THR346E, THR52G, THR540G, THR541G, THR83G, TRP227E, TRP308E, TRP312E, TRP331E, TRP45E, TRP482G, TRP63E, TYR17E, TYR20E, TYR228E, TYR335E, TYR457G, TYR464G, TYR511G, TYR539G, TYR68E, TYR76G, TYR88G, TYR91G, VAL12E, VAL15E, VAL16E, VAL24E, VAL307E, VAL310E, VAL328E, VAL344E, VAL43G, VAL49G, VAL503G, VAL514G, VAL53G, VAL59E, VAL93G
• E-H: ALA191E, ALA205E, ALA206E, ALA316H, ALA333E, ALA372H, ARG239E, ARG241E, ARG304H, ARG329H, ARG344H, ASN291E, ASN308H, ASN337E, ASN342H, ASP301E, ASP302E, ASP330H, ASP334H, GLN190E, GLN293E, GLN315H, GLN343H, GLN348H, GLN376H, GLU247E, GLU295E, GLU299E, GLU305H, GLU327H, GLU333H, GLU338E, GLU369H, GLU373H, GLU380H, GLY210E, GLY318H, GLY326H, GLY340H, GLY341H, HIS211E, HIS300E, ILE192E, ILE193E, ILE245E, ILE346H, ILE365H, LEU208E, LEU292E, LEU296E, LEU297E, LEU309H, LEU311H, LEU313H, LEU337H, LEU347H, LEU368H, LEU370H, LYS207E, LYS212E, LYS244E, LYS248E, LYS307H, LYS312H, LYS340E, LYS345H, PHE243E, PHE303H, PHE317H, PHE339E, PHE360H, PRO209E, SER298E, SER300H, SER301H, SER314H, SER319H, SER320H, SER336E, SER367H, SER371H, THR246E, THR302H, THR334E, TRP227E, TRP306H, TYR331H, TYR335E, TYR364H, TYR374H, VAL204E, VAL294E, VAL310H
• F-G: ALA191F, ALA205F, ALA206F, ALA316G, ALA333F, ALA372G, ARG239F, ARG241F, ARG304G, ARG329G, ARG344G, ASN291F, ASN308G, ASN337F, ASN342G, ASP301F, ASP302F, ASP330G, ASP334G, GLN190F, GLN293F, GLN315G, GLN343G, GLN348G, GLN376G, GLU247F, GLU295F, GLU299F, GLU305G, GLU327G, GLU333G, GLU338F, GLU369G, GLU373G, GLU380G, GLY210F, GLY318G, GLY326G, GLY340G, GLY341G, HIS211F, HIS300F, ILE192F, ILE193F, ILE245F, ILE346G, ILE365G, LEU208F, LEU292F, LEU296F, LEU297F, LEU309G, LEU311G, LEU313G, LEU337G, LEU347G, LEU368G, LEU370G, LYS207F, LYS212F, LYS244F, LYS248F, LYS307G, LYS312G, LYS340F, LYS345G, PHE243F, PHE303G, PHE317G, PHE339F, PHE360G, PRO209F, SER298F, SER300G, SER301G, SER314G, SER319G, SER320G, SER336F, SER371G, THR246F, THR302G, THR334F, TRP227F, TRP306G, TYR331G, TYR335F, TYR364G, TYR374G, VAL204F, VAL294F, VAL310G
• F-H: ALA119F, ALA25F, ALA322F, ALA333F, ALA347F, ALA462H, ALA46H, ALA470H, ALA499H, ALA505H, ALA535H, ALA60F, ALA80H, ALA84H, ARG177F, ARG216F, ARG226F, ARG22F, ARG329F, ARG40H, ARG458H, ARG70F, ARG94H, ARG97F, ARG97H, ASN304F, ASN313F, ASN337F, ASN432H, ASN44F, ASN459H, ASN467H, ASN544H, ASN54H, ASN61H, ASN78H, ASP10F, ASP14F, ASP168F, ASP18F, ASP302F, ASP30F, ASP324F, ASP325F, ASP39F, ASP41H, ASP453H, ASP55H, ASP5F, ASP62F, ASP63H, ASP86H, ASP87F, ASP89F, ASP9F, CYS27F, CYS341F, CYS474H, GLN229F, GLN2F, GLN348F, GLN349F, GLN545H, GLN56H, GLN77H, GLU247F, GLU306F, GLU410H, GLU431H, GLU437H, GLU452H, GLU472H, GLU506H, GLU533H, GLU537H, GLU59H, GLU67F, GLU85F, GLU86F, GLY21F, GLY225F, GLY305F, GLY316F, GLY323F, GLY326F, GLY45H, GLY460H, GLY477H, GLY543H, GLY62H, GLY69F, GLY72H, GLY7F, HIS120F, HIS13F, HIS23F, HIS303F, HIS510H, HIS8F, ILE224F, ILE318F, ILE345F, ILE433H, ILE47H, ILE489H, ILE504H, ILE534H, ILE538H, ILE58H, ILE61F, ILE71F, ILE82H, ILE95H, LEU11F, LEU145F, LEU230F, LEU314F, LEU319F, LEU330F, LEU38F, LEU451H, LEU454H, LEU473H, LEU476H, LEU48H, LEU507H, LEU508H, LEU531H, LEU542H, LEU547H, LEU67H, LEU71H, LEU74H, LEU90H, LEU98H, LYS115F, LYS244F, LYS248F, LYS327F, LYS332F, LYS340F, LYS34F, LYS39H, LYS40F, LYS500H, LYS501H, LYS536H, LYS60H, LYS64H, LYS68H, LYS70H, LYS85H, LYS87H, LYS89H, PHE178F, PHE19F, PHE36F, PHE434H, PHE455H, PHE469H, PHE471H, PHE4F, PHE513H, PHE69H, PHE81H, PRO118F, PRO142F, PRO175F, PRO180F, PRO222F, PRO3F, PRO407H, PRO42H, PRO509H, PRO50H, PRO512H, PRO57H, PRO66F, PRO66H, PRO73H, PRO88F, PRO92H, PRO96H, SER176F, SER179F, SER217F, SER219F, SER223F, SER28F, SER29F, SER309F, SER311F, SER320F, SER321F, SER336F, SER343F, SER414H, SER43F, SER44H, SER456H, SER463H, SER468H, SER475H, SER498H, SER548H, SER65F, SER6F, SER75H, THR246F, THR26F, THR315F, THR317F, THR334F, THR346F, THR52H, THR540H, THR541H, THR83H, TRP227F, TRP308F, TRP312F, TRP331F, TRP45F, TRP482H, TRP63F, TYR17F, TYR20F, TYR228F, TYR335F, TYR457H, TYR464H, TYR511H, TYR539H, TYR68F, TYR76H, TYR88H, TYR91H, VAL12F, VAL15F, VAL16F, VAL24F, VAL307F, VAL310F, VAL328F, VAL344F, VAL43H, VAL49H, VAL503H, VAL514H, VAL53H, VAL59F, VAL93H
• F-I: ALA53F, ALA53I, ARG146F, ARG146I, ARG52F, ARG52I, ARG96F, ARG96I, ARG97F, ARG97I, ASN99F, ASN99I, ASP10F, ASP10I, ASP30F, ASP30I, ASP49F, ASP49I, ASP55F, ASP55I, ASP78F, ASP78I, ASP87F, ASP87I, ASP9F, ASP9I, CYS102F, CYS102I, CYS93F, CYS93I, GLN31F, GLN31I, GLN90F, GLN90I, GLU85F, GLU85I, GLU91F, GLU91I, GLY95F, GLY95I, HIS32F, HIS32I, HIS54F, HIS54I, HIS8F, HIS8I, ILE58F, ILE58I, LEU101F, LEU101I, LEU11F, LEU11I, LYS100F, LYS100I, LYS79F, LYS79I, LYS82F, LYS82I, SER28F, SER28I, SER29F, SER29I, SER50F, SER50I, SER56F, SER56I, SER57F, SER57I, SER94F, SER94I, THR103F, THR103I, THR80F, THR80I, TRP51F, TRP51I, TRP84F, TRP84I, TRP98F, TRP98I
• F-K: ARG96F, TYR88K
• G-H: ALA372G, ALA372H, ALA462G, ALA462H, ARG304G, ARG304H, ARG458G, ARG458H, ASN200G, ASN200H, ASN432G, ASN432H, ASN459G, ASN459H, ASP193G, ASP193H, ASP196G, ASP196H, ASP396G, ASP396H, GLN195G, GLN195H, GLN376G, GLN376H, GLN392G, GLN392H, GLU198G, GLU198H, GLU199G, GLU199H, GLU369G, GLU369H, GLU373G, GLU373H, GLU431G, GLU431H, GLU435G, GLU435H, GLU437G, GLU437H, GLU452H, GLY194G, GLY194H, GLY400G, GLY400H, GLY436G, GLY436H, GLY460G, GLY460H, HIS403G, HIS403H, ILE365G, ILE365H, ILE397G, ILE397H, ILE398G, ILE398H, ILE402G, ILE402H, ILE430G, ILE430H, ILE433G, ILE433H, LEU192G, LEU192H, LEU368G, LEU368H, LEU370G, LEU370H, LEU375G, LEU375H, LEU379G, LEU379H, LYS401G, LYS401H, PHE434G, PHE434H, PRO366G, PRO366H, PRO407G, PRO407H, SER300G, SER300H, SER301G, SER301H, SER367G, SER367H, SER371G, SER371H, SER399G, SER399H, SER404G, SER404H, SER456G, SER456H, TYR189G, TYR189H, TYR364G, TYR364H, TYR374G, TYR457G, TYR457H, TYR464G, TYR464H, VAL197G, VAL197H, VAL395G, VAL395H, VAL408G, VAL408H
• H-I: ARG96I, TYR88H
• I-K: ALA119I, ALA25I, ALA322I, ALA333I, ALA347I, ALA462K, ALA46K, ALA470K, ALA499K, ALA505K, ALA535K, ALA549K, ALA60I, ALA80K, ALA84K, ARG177I, ARG216I, ARG226I, ARG22I, ARG329I, ARG40K, ARG458K, ARG70I, ARG94K, ARG97I, ARG97K, ASN304I, ASN313I, ASN337I, ASN432K, ASN44I, ASN459K, ASN467K, ASN544K, ASN54K, ASN551K, ASN61K, ASN78K, ASP10I, ASP14I, ASP168I, ASP18I, ASP302I, ASP30I, ASP324I, ASP325I, ASP41K, ASP453K, ASP55K, ASP5I, ASP62I, ASP63K, ASP86K, ASP87I, ASP89I, ASP9I, CYS27I, CYS341I, CYS474K, GLN229I, GLN2I, GLN348I, GLN545K, GLN56K, GLN77K, GLU247I, GLU306I, GLU410K, GLU431K, GLU452K, GLU472K, GLU506K, GLU533K, GLU537K, GLU59K, GLU67I, GLU85I, GLU86I, GLY21I, GLY225I, GLY305I, GLY316I, GLY323I, GLY326I, GLY45K, GLY460K, GLY477K, GLY69I, GLY72K, GLY7I, HIS120I, HIS13I, HIS23I, HIS303I, HIS510K, HIS550K, HIS8I, ILE224I, ILE318I, ILE345I, ILE433K, ILE47K, ILE489K, ILE504K, ILE534K, ILE538K, ILE58K, ILE61I, ILE71I, ILE82K, ILE95K, LEU11I, LEU145I, LEU230I, LEU314I, LEU319I, LEU330I, LEU38I, LEU451K, LEU454K, LEU473K, LEU476K, LEU48K, LEU507K, LEU508K, LEU531K, LEU542K, LEU547K, LEU67K, LEU71K, LEU74K, LEU90K, LEU98K, LYS115I, LYS244I, LYS327I, LYS332I, LYS340I, LYS34I, LYS39K, LYS40I, LYS500K, LYS501K, LYS536K, LYS60K, LYS64K, LYS68K, LYS70K, LYS85K, LYS87K, LYS89K, PHE178I, PHE19I, PHE339I, PHE36I, PHE434K, PHE455K, PHE469K, PHE471K, PHE4I, PHE513K, PHE69K, PHE81K, PRO118I, PRO175I, PRO180I, PRO222I, PRO3I, PRO407K, PRO42K, PRO509K, PRO50K, PRO512K, PRO57K, PRO66I, PRO66K, PRO73K, PRO88I, PRO92K, PRO96K, SER176I, SER179I, SER217I, SER219I, SER223I, SER28I, SER29I, SER309I, SER311I, SER320I, SER321I, SER336I, SER343I, SER414K, SER43I, SER44K, SER456K, SER463K, SER468K, SER475K, SER498K, SER548K, SER65I, SER6I, SER75K, THR246I, THR26I, THR315I, THR317I, THR334I, THR346I, THR52K, THR540K, THR541K, THR83K, TRP227I, TRP308I, TRP312I, TRP331I, TRP45I, TRP482K, TRP63I, TYR17I, TYR20I, TYR228I, TYR335I, TYR457K, TYR464K, TYR511K, TYR68I, TYR76K, TYR88K, TYR91K, VAL12I, VAL15I, VAL16I, VAL24I, VAL307I, VAL310I, VAL328I, VAL344I, VAL43K, VAL49K, VAL503K, VAL514K, VAL53K, VAL59I, VAL93K
• I-L: ALA191I, ALA205I, ALA206I, ALA316L, ALA333I, ALA372L, ARG239I, ARG241I, ARG304L, ARG329L, ARG344L, ASN291I, ASN308L, ASN337I, ASN342L, ASP301I, ASP302I, ASP330L, ASP334L, GLN190I, GLN293I, GLN315L, GLN343L, GLN348L, GLN376L, GLU189I, GLU247I, GLU295I, GLU299I, GLU305L, GLU327L, GLU333L, GLU338I, GLU369L, GLU373L, GLU380L, GLY210I, GLY318L, GLY326L, GLY340L, GLY341L, HIS211I, HIS300I, ILE192I, ILE193I, ILE240I, ILE245I, ILE365L, LEU208I, LEU292I, LEU296I, LEU297I, LEU309L, LEU311L, LEU313L, LEU337L, LEU347L, LEU368L, LEU370L, LYS207I, LYS212I, LYS244I, LYS248I, LYS307L, LYS312L, LYS340I, LYS345L, PHE243I, PHE303L, PHE317L, PHE339I, PHE360L, PRO209I, SER298I, SER300L, SER301L, SER314L, SER319L, SER320L, SER336I, SER367L, SER371L, THR246I, THR302L, THR334I, TRP227I, TRP306L, TYR228I, TYR331L, TYR335I, TYR364L, TYR374L, VAL204I, VAL294I, VAL310L
• J-K: ALA191J, ALA205J, ALA206J, ALA316K, ALA333J, ALA372K, ARG239J, ARG241J, ARG304K, ARG329K, ARG344K, ASN291J, ASN308K, ASN337J, ASN342K, ASP301J, ASP302J, ASP330K, ASP334K, GLN190J, GLN293J, GLN315K, GLN343K, GLN348K, GLN376K, GLU247J, GLU295J, GLU299J, GLU305K, GLU327K, GLU333K, GLU338J, GLU369K, GLU373K, GLU380K, GLY210J, GLY318K, GLY326K, GLY340K, GLY341K, HIS211J, HIS300J, ILE192J, ILE193J, ILE245J, ILE346K, ILE365K, LEU208J, LEU292J, LEU296J, LEU297J, LEU309K, LEU311K, LEU337K, LEU347K, LEU368K, LEU370K, LYS207J, LYS212J, LYS244J, LYS248J, LYS307K, LYS312K, LYS340J, LYS345K, PHE243J, PHE303K, PHE317K, PHE339J, PHE360K, PRO209J, SER298J, SER301K, SER314K, SER319K, SER320K, SER336J, SER367K, SER371K, THR246J, THR302K, THR334J, TRP227J, TRP306K, TYR331K, TYR335J, TYR364K, TYR374K, VAL294J, VAL310K
• J-L: ALA119J, ALA25J, ALA322J, ALA333J, ALA347J, ALA462L, ALA46L, ALA470L, ALA499L, ALA505L, ALA535L, ALA60J, ALA80L, ALA84L, ARG177J, ARG216J, ARG226J, ARG22J, ARG329J, ARG40L, ARG458L, ARG70J, ARG94L, ARG97L, ASN304J, ASN313J, ASN337J, ASN432L, ASN44J, ASN459L, ASN467L, ASN544L, ASN54L, ASN61L, ASN78L, ASP10J, ASP14J, ASP168J, ASP18J, ASP302J, ASP30J, ASP324J, ASP325J, ASP39J, ASP41L, ASP453L, ASP55L, ASP5J, ASP62J, ASP63L, ASP86L, ASP9J, CYS27J, CYS341J, CYS474L, GLN229J, GLN2J, GLN348J, GLN349J, GLN545L, GLN56L, GLN77L, GLU247J, GLU306J, GLU410L, GLU452L, GLU472L, GLU506L, GLU533L, GLU537L, GLU59L, GLU67J, GLU85J, GLY122J, GLY21J, GLY225J, GLY305J, GLY316J, GLY323J, GLY326J, GLY45L, GLY460L, GLY477L, GLY543L, GLY62L, GLY69J, GLY72L, GLY7J, HIS120J, HIS13J, HIS23J, HIS303J, HIS510L, HIS8J, ILE224J, ILE318J, ILE345J, ILE433L, ILE47L, ILE489L, ILE504L, ILE534L, ILE538L, ILE58L, ILE61J, ILE71J, ILE82L, ILE95L, LEU11J, LEU121J, LEU123J, LEU145J, LEU230J, LEU314J, LEU319J, LEU330J, LEU38J, LEU451L, LEU454L, LEU473L, LEU476L, LEU48L, LEU507L, LEU508L, LEU531L, LEU542L, LEU67L, LEU71L, LEU74L, LEU90L, LEU98L, LYS115J, LYS244J, LYS327J, LYS332J, LYS340J, LYS34J, LYS40J, LYS500L, LYS501L, LYS536L, LYS60L, LYS64L, LYS68L, LYS70L, LYS85L, LYS87L, LYS89L, PHE178J, PHE19J, PHE339J, PHE36J, PHE434L, PHE455L, PHE469L, PHE471L, PHE4J, PHE513L, PHE69L, PHE81L, PRO118J, PRO142J, PRO175J, PRO180J, PRO222J, PRO3J, PRO407L, PRO42L, PRO509L, PRO50L, PRO512L, PRO532L, PRO57L, PRO66J, PRO66L, PRO73L, PRO88J, PRO92L, PRO96L, SER176J, SER179J, SER217J, SER219J, SER223J, SER28J, SER29J, SER309J, SER311J, SER320J, SER321J, SER336J, SER343J, SER414L, SER43J, SER44L, SER456L, SER463L, SER468L, SER475L, SER498L, SER65J, SER6J, SER75L, THR246J, THR26J, THR315J, THR317J, THR334J, THR346J, THR52L, THR540L, THR541L, THR83L, TRP227J, TRP308J, TRP312J, TRP331J, TRP45J, TRP482L, TRP63J, TYR17J, TYR20J, TYR228J, TYR335J, TYR457L, TYR464L, TYR511L, TYR539L, TYR68J, TYR76L, TYR88L, TYR91L, VAL12J, VAL15J, VAL16J, VAL24J, VAL307J, VAL310J, VAL328J, VAL344J, VAL49L, VAL503L, VAL514L, VAL53L, VAL59J, VAL93L
• K-L: ALA372K, ALA372L, ALA462K, ALA462L, ARG304K, ARG304L, ARG458K, ARG458L, ASN200K, ASN200L, ASN432K, ASN432L, ASN459K, ASN459L, ASP193K, ASP193L, ASP196K, ASP196L, ASP396K, ASP396L, GLN195K, GLN195L, GLN376K, GLN376L, GLN392K, GLN392L, GLU198K, GLU198L, GLU199K, GLU199L, GLU369K, GLU369L, GLU373K, GLU373L, GLU380K, GLU431K, GLU431L, GLU435K, GLU435L, GLU452K, GLY194K, GLY194L, GLY400K, GLY400L, GLY436L, GLY460K, GLY460L, HIS403K, HIS403L, ILE365K, ILE365L, ILE397K, ILE397L, ILE398K, ILE398L, ILE402K, ILE402L, ILE430K, ILE430L, ILE433K, ILE433L, LEU192K, LEU192L, LEU368K, LEU368L, LEU370K, LEU370L, LEU375K, LEU375L, LEU379K, LEU379L, LYS401K, LYS401L, PHE434K, PHE434L, PRO366K, PRO366L, PRO407K, PRO407L, SER300K, SER300L, SER367K, SER367L, SER371K, SER371L, SER399K, SER399L, SER404K, SER404L, SER44L, SER456K, SER456L, TYR189K, TYR189L, TYR364K, TYR364L, TYR374K, TYR374L, TYR457K, TYR457L, TYR464K, TYR464L, VAL126K, VAL126L, VAL197K, VAL197L, VAL395K, VAL395L, VAL408K, VAL408L