3F3F

crystal structure of the nucleoporin pair nup85-seh1, space group p21

• Total interactions analyzed: 28
• Total true interactions: 11
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 238
  • Norm. En. per Res.: -4.0102
• Hub Node: B(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-90.8793	-40.3245	-823.213	-954.4168	238	43	22	33276	7	57	57
A-D	-22.6447	-36.9854	-193.354	-252.9842	98	12	2	8602	5	34	31
B-C	-15.6167	-35.9988	-171.86	-223.4755	89	5	2	7771	5	34	30
B-D	-91.1677	-17.4375	-835.907	-944.5122	259	55	23	35129	5	63	57
B-E	-7.4166	-31.0339	-68.622	-107.0725	47	2	0	2799	3	39	27
C-D	-37.1582	57.3554	-221.936	-201.7388	120	6	4	9231	2	32	34
E-G	-62.8692	-22.3442	-736.765	-821.9784	229	23	19	30382	5	55	54
E-H	-20.2769	-35.4851	-173.13	-228.892	92	7	2	7679	3	33	29
F-G	-32.609	-34.4517	-183.134	-250.1947	94	9	3	7902	5	33	30
F-H	-81.9305	-14.8423	-844.771	-941.5437	250	53	23	34008	6	59	58
G-H	-36.4722	51.4387	-251.815	-236.8485	128	13	4	10451	1	39	46

Interface residues

• A-C: ALA119A, ALA25A, ALA322A, ALA333A, ALA462C, ALA470C, ALA499C, ALA505C, ALA535C, ALA60A, ALA80C, ALA84C, ARG177A, ARG216A, ARG226A, ARG22A, ARG329A, ARG458C, ARG70A, ARG94C, ARG97C, ASN304A, ASN313A, ASN337A, ASN432C, ASN44A, ASN459C, ASN467C, ASN544C, ASN54C, ASN61C, ASN78C, ASP10A, ASP14A, ASP168A, ASP18A, ASP30A, ASP324A, ASP325A, ASP453C, ASP478C, ASP55C, ASP5A, ASP62A, ASP63C, ASP86C, ASP9A, CYS27A, CYS341A, CYS474C, GLN2A, GLN56C, GLN77C, GLU247A, GLU306A, GLU410C, GLU452C, GLU472C, GLU506C, GLU533C, GLU537C, GLU67A, GLU85A, GLY21A, GLY225A, GLY305A, GLY316A, GLY323A, GLY326A, GLY460C, GLY477C, GLY543C, GLY69A, GLY72C, GLY7A, HIS120A, HIS13A, HIS1A, HIS23A, HIS303A, HIS510C, HIS8A, ILE224A, ILE318A, ILE345A, ILE433C, ILE47C, ILE489C, ILE504C, ILE534C, ILE538C, ILE58C, ILE61A, ILE82C, ILE95C, LEU11A, LEU145A, LEU230A, LEU314A, LEU319A, LEU330A, LEU38A, LEU451C, LEU454C, LEU473C, LEU476C, LEU48C, LEU507C, LEU508C, LEU531C, LEU542C, LEU67C, LEU71C, LEU74C, LEU90C, LEU98C, LYS115A, LYS244A, LYS248A, LYS327A, LYS332A, LYS340A, LYS34A, LYS40A, LYS479C, LYS500C, LYS501C, LYS536C, LYS64C, LYS68C, LYS70C, LYS85C, LYS87C, LYS89C, MET1A, MET342A, MET461C, MET465C, MET502C, MET51C, MET522C, MET65C, MET79C, PHE178A, PHE19A, PHE339A, PHE36A, PHE434C, PHE455C, PHE469C, PHE471C, PHE4A, PHE513C, PHE69C, PHE81C, PRO142A, PRO175A, PRO222A, PRO3A, PRO407C, PRO509C, PRO50C, PRO512C, PRO532C, PRO57C, PRO66A, PRO66C, PRO73C, PRO88A, PRO92C, PRO96C, SER176A, SER179A, SER217A, SER219A, SER223A, SER28A, SER29A, SER309A, SER311A, SER320A, SER321A, SER336A, SER343A, SER411C, SER414C, SER43A, SER456C, SER463C, SER468C, SER475C, SER498C, SER65A, SER6A, SER75C, THR246A, THR26A, THR315A, THR317A, THR334A, THR346A, THR52C, THR540C, THR541C, THR83C, TRP227A, TRP308A, TRP312A, TRP331A, TRP45A, TRP482C, TRP63A, TYR17A, TYR20A, TYR228A, TYR335A, TYR457C, TYR464C, TYR511C, TYR539C, TYR68A, TYR76C, TYR88C, TYR91C, VAL12A, VAL15A, VAL16A, VAL24A, VAL307A, VAL310A, VAL328A, VAL344A, VAL49C, VAL503C, VAL514C, VAL53C, VAL59A, VAL93C
• A-D: ALA191A, ALA205A, ALA206A, ALA316D, ALA333A, ALA372D, ARG239A, ARG241A, ARG304D, ARG329D, ARG344D, ASN308D, ASN337A, ASN342D, ASP301A, ASP302A, ASP330D, ASP334D, CYS341A, GLN190A, GLN289A, GLN293A, GLN315D, GLN343D, GLN348D, GLN376D, GLU189A, GLU247A, GLU295A, GLU299A, GLU305D, GLU327D, GLU333D, GLU338A, GLU369D, GLU373D, GLU380D, GLY210A, GLY318D, GLY326D, GLY340D, GLY341D, HIS211A, HIS300A, ILE192A, ILE193A, ILE242A, ILE245A, ILE365D, LEU208A, LEU288A, LEU292A, LEU296A, LEU297A, LEU309D, LEU311D, LEU313D, LEU337D, LEU347D, LEU368D, LEU370D, LYS207A, LYS212A, LYS244A, LYS248A, LYS307D, LYS312D, LYS340A, LYS345D, MET377D, PHE243A, PHE303D, PHE317D, PHE339A, PHE360D, PRO209A, SER290A, SER298A, SER300D, SER301D, SER314D, SER319D, SER320D, SER336A, SER371D, THR246A, THR322D, THR334A, TRP227A, TRP306D, TRP331A, TYR331D, TYR335A, TYR364D, TYR374D, VAL204A, VAL294A, VAL310D
• B-C: ALA191B, ALA205B, ALA206B, ALA316C, ALA372C, ARG239B, ARG241B, ARG304C, ARG329C, ARG344C, ASN291B, ASN308C, ASN337B, ASN342C, ASP301B, ASP302B, ASP330C, ASP334C, CYS341B, GLN190B, GLN293B, GLN315C, GLN343C, GLN348C, GLN376C, GLU295B, GLU299B, GLU305C, GLU327C, GLU333C, GLU338B, GLU369C, GLU373C, GLU380C, GLY210B, GLY318C, GLY326C, GLY340C, GLY341C, HIS211B, HIS300B, ILE192B, ILE193B, ILE242B, ILE245B, ILE365C, LEU208B, LEU292B, LEU296B, LEU297B, LEU309C, LEU311C, LEU313C, LEU337C, LEU347C, LEU368C, LEU370C, LYS207B, LYS212B, LYS244B, LYS248B, LYS307C, LYS312C, LYS340B, LYS345C, MET377C, PHE243B, PHE317C, PHE339B, PHE360C, PRO209B, SER298B, SER301C, SER314C, SER319C, SER320C, SER336B, SER367C, SER371C, THR246B, THR322C, THR334B, TRP306C, TRP331B, TYR331C, TYR335B, TYR364C, TYR374C, VAL294B
• B-D: ALA119B, ALA25B, ALA322B, ALA333B, ALA462D, ALA46D, ALA470D, ALA499D, ALA505D, ALA535D, ALA549D, ALA60B, ALA80D, ALA84D, ARG177B, ARG216B, ARG226B, ARG22B, ARG329B, ARG458D, ARG70B, ARG94D, ARG97D, ASN304B, ASN313B, ASN337B, ASN432D, ASN44B, ASN459D, ASN467D, ASN544D, ASN54D, ASN78D, ASP10B, ASP14B, ASP168B, ASP18B, ASP301B, ASP302B, ASP30B, ASP324B, ASP325B, ASP453D, ASP55D, ASP5B, ASP62B, ASP63D, ASP86D, ASP87B, ASP89B, ASP9B, CYS27B, CYS341B, CYS474D, GLN293B, GLN2B, GLN545D, GLN56D, GLN77D, GLU247B, GLU306B, GLU410D, GLU431D, GLU437D, GLU449D, GLU452D, GLU472D, GLU506D, GLU533D, GLU537D, GLU67B, GLU85B, GLU86B, GLY21B, GLY225B, GLY305B, GLY316B, GLY323B, GLY326B, GLY45D, GLY460D, GLY477D, GLY543D, GLY69B, GLY72D, GLY7B, HIS120B, HIS13B, HIS1B, HIS23B, HIS300B, HIS303B, HIS510D, HIS8B, ILE224B, ILE318B, ILE345B, ILE433D, ILE47D, ILE489D, ILE504D, ILE534D, ILE538D, ILE58D, ILE61B, ILE71B, ILE82D, ILE95D, LEU101B, LEU11B, LEU123B, LEU145B, LEU230B, LEU314B, LEU319B, LEU330B, LEU38B, LEU451D, LEU454D, LEU473D, LEU476D, LEU48D, LEU507D, LEU508D, LEU531D, LEU542D, LEU547D, LEU67D, LEU71D, LEU74D, LEU90D, LEU98D, LYS115B, LYS244B, LYS248B, LYS327B, LYS332B, LYS340B, LYS34B, LYS40B, LYS500D, LYS501D, LYS536D, LYS64D, LYS68D, LYS70D, LYS85D, LYS87D, LYS89D, MET1B, MET342B, MET450D, MET461D, MET465D, MET502D, MET51D, MET546D, MET65D, MET79D, PHE178B, PHE19B, PHE339B, PHE36B, PHE434D, PHE455D, PHE469D, PHE471D, PHE4B, PHE513D, PHE69D, PHE81D, PRO142B, PRO175B, PRO1B, PRO222B, PRO3B, PRO407D, PRO509D, PRO50D, PRO512D, PRO532D, PRO57D, PRO66B, PRO66D, PRO73D, PRO88B, PRO92D, PRO96D, SER113B, SER143B, SER176B, SER179B, SER217B, SER219B, SER223B, SER28B, SER29B, SER309B, SER311B, SER320B, SER321B, SER336B, SER343B, SER411D, SER414D, SER43B, SER44D, SER456D, SER463D, SER468D, SER475D, SER548D, SER65B, SER6B, SER75D, THR100D, THR246B, THR26B, THR315B, THR317B, THR334B, THR346B, THR52D, THR540D, THR541D, THR83D, TRP227B, TRP308B, TRP312B, TRP331B, TRP45B, TRP482D, TYR17B, TYR20B, TYR228B, TYR335B, TYR457D, TYR464D, TYR511D, TYR539D, TYR68B, TYR76D, TYR88D, TYR91D, VAL12B, VAL15B, VAL16B, VAL24B, VAL307B, VAL310B, VAL328B, VAL344B, VAL408D, VAL49D, VAL503D, VAL514D, VAL53D, VAL59B, VAL93D
• B-E: ALA53B, ALA53E, ARG146B, ARG146E, ARG52B, ARG52E, ARG96B, ARG96E, ARG97B, ARG97E, ASN99B, ASN99E, ASP49B, ASP49E, ASP55B, ASP55E, ASP87B, ASP87E, ASP89B, ASP89E, GLN31B, GLN90B, GLN90E, GLU85B, GLU85E, GLU91B, GLU91E, GLU92E, GLY95B, GLY95E, HIS32B, HIS54B, ILE33E, LYS100B, LYS100E, LYS82B, SER50B, SER50E, SER94B, SER94E, THR103B, TRP51B, TRP51E, TRP84B, TRP84E, TRP98B, TRP98E
• C-D: ALA372C, ALA372D, ALA462C, ALA462D, ARG201C, ARG304C, ARG304D, ARG458C, ARG458D, ASN200C, ASN200D, ASN308C, ASN432C, ASN432D, ASN439D, ASN459C, ASN459D, ASP193C, ASP193D, ASP196C, ASP196D, ASP298C, ASP396C, ASP396D, GLN195C, GLN195D, GLN376C, GLN376D, GLN392C, GLN392D, GLU198C, GLU198D, GLU199C, GLU199D, GLU369C, GLU369D, GLU373C, GLU373D, GLU380C, GLU431C, GLU431D, GLU435C, GLU435D, GLU437D, GLU449D, GLY194C, GLY194D, GLY400C, GLY400D, GLY436C, GLY436D, GLY45D, GLY460C, GLY460D, HIS403C, HIS403D, ILE365C, ILE365D, ILE398C, ILE398D, ILE402C, ILE402D, ILE430C, ILE430D, ILE433C, ILE433D, LEU192C, LEU192D, LEU368C, LEU368D, LEU370C, LEU370D, LEU375C, LEU375D, LEU379C, LEU379D, LEU451C, LEU451D, LYS401C, LYS401D, LYS438D, MET188C, MET188D, MET450D, MET461C, MET461D, PHE434C, PHE434D, PRO366C, PRO366D, PRO407C, PRO407D, SER299C, SER300C, SER300D, SER301C, SER367C, SER367D, SER371C, SER371D, SER399C, SER399D, SER404C, SER404D, SER456C, SER456D, TYR189C, TYR189D, TYR364C, TYR364D, TYR374C, TYR374D, TYR457C, TYR457D, VAL197C, VAL197D, VAL395C, VAL395D, VAL408C, VAL408D
• E-G: ALA119E, ALA25E, ALA322E, ALA333E, ALA462G, ALA470G, ALA499G, ALA505G, ALA535G, ALA60E, ALA80G, ALA84G, ARG177E, ARG216E, ARG226E, ARG22E, ARG329E, ARG458G, ARG70E, ARG94G, ARG97G, ASN304E, ASN313E, ASN337E, ASN432G, ASN439G, ASN44E, ASN459G, ASN467G, ASN544G, ASN61G, ASN78G, ASP10E, ASP14E, ASP168E, ASP18E, ASP30E, ASP324E, ASP325E, ASP453G, ASP478G, ASP5E, ASP62E, ASP63G, ASP86G, ASP9E, CYS27E, CYS474G, GLN229E, GLN2E, GLN545G, GLN77G, GLU247E, GLU306E, GLU410G, GLU452G, GLU472G, GLU506G, GLU533G, GLU537G, GLU67E, GLY21E, GLY225E, GLY305E, GLY316E, GLY323E, GLY326E, GLY460G, GLY477G, GLY543G, GLY62G, GLY69E, GLY72G, GLY7E, HIS120E, HIS13E, HIS1E, HIS23E, HIS303E, HIS510G, HIS8E, ILE224E, ILE318E, ILE345E, ILE433G, ILE489G, ILE504G, ILE534G, ILE538G, ILE61E, ILE82G, ILE95G, LEU11E, LEU230E, LEU314E, LEU319E, LEU330E, LEU38E, LEU451G, LEU454G, LEU473G, LEU476G, LEU507G, LEU508G, LEU531G, LEU542G, LEU67G, LEU71G, LEU74G, LEU90G, LEU98G, LYS115E, LYS244E, LYS248E, LYS327E, LYS332E, LYS340E, LYS34E, LYS40E, LYS479G, LYS500G, LYS501G, LYS536G, LYS64G, LYS68G, LYS70G, LYS85G, LYS87G, LYS89G, MET1E, MET342E, MET450G, MET461G, MET465G, MET502G, MET522G, MET65G, MET79G, PHE178E, PHE19E, PHE339E, PHE36E, PHE434G, PHE455G, PHE469G, PHE471G, PHE4E, PHE513G, PHE69G, PHE81G, PRO175E, PRO180E, PRO1E, PRO222E, PRO3E, PRO407G, PRO509G, PRO512G, PRO532G, PRO66E, PRO66G, PRO73G, PRO88E, PRO92G, PRO96G, SER176E, SER179E, SER217E, SER219E, SER223E, SER28E, SER29E, SER309E, SER311E, SER320E, SER321E, SER336E, SER343E, SER411G, SER414G, SER43E, SER456G, SER463G, SER468G, SER475G, SER548G, SER65E, SER6E, SER75G, THR100G, THR246E, THR26E, THR315E, THR317E, THR334E, THR346E, THR540G, THR541G, THR83G, TRP227E, TRP308E, TRP312E, TRP331E, TRP45E, TRP482G, TYR17E, TYR20E, TYR228E, TYR335E, TYR457G, TYR464G, TYR511G, TYR539G, TYR68E, TYR76G, TYR88G, TYR91G, VAL12E, VAL15E, VAL16E, VAL24E, VAL307E, VAL310E, VAL328E, VAL344E, VAL503G, VAL514G, VAL59E, VAL93G
• E-H: ALA191E, ALA205E, ALA206E, ALA316H, ALA372H, ARG239E, ARG241E, ARG304H, ARG329H, ARG344H, ASN291E, ASN308H, ASN337E, ASN342H, ASP301E, ASP302E, ASP330H, ASP334H, CYS341E, GLN190E, GLN293E, GLN315H, GLN343H, GLN348H, GLN376H, GLU247E, GLU295E, GLU299E, GLU305H, GLU327H, GLU333H, GLU338E, GLU369H, GLU373H, GLU380H, GLY210E, GLY318H, GLY326H, GLY340H, GLY341H, HIS211E, HIS300E, ILE192E, ILE193E, ILE242E, ILE245E, ILE365H, LEU208E, LEU292E, LEU296E, LEU297E, LEU309H, LEU311H, LEU337H, LEU347H, LEU368H, LEU370H, LYS207E, LYS212E, LYS244E, LYS248E, LYS307H, LYS312H, LYS340E, LYS345H, MET377H, PHE243E, PHE303H, PHE317H, PHE339E, PHE360H, PRO209E, SER298E, SER301H, SER314H, SER319H, SER320H, SER336E, SER367H, SER371H, THR246E, THR302H, THR334E, TRP227E, TRP306H, TRP331E, TYR331H, TYR335E, TYR364H, TYR374H, VAL294E, VAL310H
• F-G: ALA191F, ALA205F, ALA206F, ALA316G, ALA372G, ARG239F, ARG241F, ARG304G, ARG329G, ARG344G, ASN291F, ASN308G, ASN337F, ASN342G, ASP301F, ASP302F, ASP330G, ASP334G, CYS341F, GLN190F, GLN293F, GLN315G, GLN343G, GLN348G, GLN376G, GLU189F, GLU247F, GLU295F, GLU299F, GLU305G, GLU327G, GLU333G, GLU338F, GLU369G, GLU373G, GLU380G, GLY210F, GLY318G, GLY326G, GLY340G, GLY341G, HIS211F, HIS300F, ILE192F, ILE193F, ILE242F, ILE245F, ILE365G, LEU208F, LEU292F, LEU296F, LEU297F, LEU309G, LEU311G, LEU313G, LEU337G, LEU347G, LEU368G, LEU370G, LYS207F, LYS212F, LYS244F, LYS248F, LYS307G, LYS312G, LYS340F, LYS345G, MET377G, PHE243F, PHE303G, PHE317G, PHE339F, PHE360G, PRO209F, SER298F, SER301G, SER314G, SER319G, SER320G, SER336F, SER367G, SER371G, THR246F, THR322G, THR334F, TRP306G, TRP331F, TYR331G, TYR335F, TYR364G, TYR374G, VAL204F, VAL294F, VAL310G
• F-H: ALA119F, ALA25F, ALA322F, ALA333F, ALA347F, ALA462H, ALA46H, ALA470H, ALA499H, ALA505H, ALA535H, ALA60F, ALA80H, ALA84H, ARG177F, ARG216F, ARG226F, ARG22F, ARG329F, ARG458H, ARG70F, ARG94H, ARG97H, ASN304F, ASN313F, ASN337F, ASN432H, ASN44F, ASN459H, ASN467H, ASN544H, ASN54H, ASN61H, ASN78H, ASP10F, ASP14F, ASP168F, ASP18F, ASP302F, ASP30F, ASP324F, ASP325F, ASP453H, ASP55H, ASP5F, ASP62F, ASP63H, ASP86H, ASP9F, CYS27F, CYS341F, CYS474H, GLN2F, GLN545H, GLN56H, GLN77H, GLU247F, GLU306F, GLU410H, GLU431H, GLU437H, GLU452H, GLU472H, GLU506H, GLU533H, GLU537H, GLU59H, GLU67F, GLU85F, GLU86F, GLY21F, GLY225F, GLY305F, GLY316F, GLY323F, GLY326F, GLY45H, GLY460H, GLY477H, GLY543H, GLY62H, GLY69F, GLY72H, GLY7F, HIS120F, HIS13F, HIS1F, HIS23F, HIS303F, HIS510H, HIS8F, ILE224F, ILE318F, ILE345F, ILE433H, ILE47H, ILE489H, ILE504H, ILE534H, ILE538H, ILE58H, ILE61F, ILE71F, ILE82H, ILE95H, LEU11F, LEU145F, LEU230F, LEU314F, LEU319F, LEU330F, LEU38F, LEU451H, LEU454H, LEU473H, LEU476H, LEU48H, LEU507H, LEU508H, LEU531H, LEU542H, LEU67H, LEU71H, LEU74H, LEU90H, LEU98H, LYS115F, LYS244F, LYS248F, LYS327F, LYS332F, LYS340F, LYS34F, LYS40F, LYS500H, LYS501H, LYS536H, LYS60H, LYS64H, LYS68H, LYS70H, LYS85H, LYS87H, LYS89H, MET1F, MET342F, MET450H, MET461H, MET465H, MET502H, MET51H, MET65H, MET79H, PHE178F, PHE19F, PHE339F, PHE36F, PHE434H, PHE455H, PHE469H, PHE471H, PHE4F, PHE513H, PHE69H, PHE81H, PRO142F, PRO175F, PRO222F, PRO3F, PRO407H, PRO509H, PRO50H, PRO512H, PRO532H, PRO57H, PRO66F, PRO66H, PRO73H, PRO88F, PRO92H, PRO96H, SER113F, SER176F, SER179F, SER217F, SER219F, SER223F, SER28F, SER29F, SER309F, SER311F, SER320F, SER321F, SER336F, SER343F, SER411H, SER414H, SER43F, SER456H, SER463H, SER468H, SER475H, SER498H, SER65F, SER6F, SER75H, THR246F, THR26F, THR315F, THR317F, THR334F, THR346F, THR496H, THR52H, THR540H, THR541H, THR83H, TRP227F, TRP308F, TRP312F, TRP331F, TRP45F, TRP482H, TRP63F, TYR17F, TYR20F, TYR228F, TYR335F, TYR457H, TYR464H, TYR511H, TYR539H, TYR68F, TYR76H, TYR88H, TYR91H, VAL12F, VAL15F, VAL16F, VAL24F, VAL307F, VAL310F, VAL328F, VAL344F, VAL49H, VAL503H, VAL514H, VAL53H, VAL59F, VAL93H
• G-H: ALA372G, ALA372H, ALA462G, ALA462H, ARG304G, ARG304H, ARG458G, ARG458H, ASN200G, ASN200H, ASN432G, ASN432H, ASN439G, ASN439H, ASN459G, ASN459H, ASP193G, ASP193H, ASP196G, ASP196H, ASP298G, ASP396G, ASP396H, ASP441G, GLN195G, GLN195H, GLN376G, GLN376H, GLN392G, GLN392H, GLU198G, GLU198H, GLU199G, GLU199H, GLU305H, GLU369G, GLU369H, GLU373G, GLU373H, GLU431G, GLU431H, GLU435G, GLU435H, GLU437G, GLU437H, GLY194G, GLY194H, GLY400G, GLY400H, GLY436G, GLY436H, GLY460G, GLY460H, HIS403G, HIS403H, ILE365G, ILE365H, ILE398G, ILE398H, ILE402G, ILE402H, ILE433G, ILE433H, LEU192G, LEU192H, LEU368G, LEU368H, LEU370G, LEU370H, LEU375G, LEU375H, LEU379G, LEU379H, LEU451G, LEU451H, LYS307H, LYS401G, LYS401H, LYS438G, LYS438H, MET188G, MET188H, MET450G, MET450H, MET461G, MET461H, PHE434G, PHE434H, PRO366G, PRO366H, PRO407G, PRO407H, SER299G, SER299H, SER300G, SER300H, SER301G, SER301H, SER367G, SER367H, SER371G, SER371H, SER399G, SER399H, SER404G, SER404H, SER440G, SER440H, SER456G, SER456H, THR302G, THR302H, TYR189G, TYR189H, TYR364G, TYR364H, TYR374G, TYR374H, TYR457G, TYR457H, TYR464G, TYR464H, VAL197G, VAL197H, VAL395G, VAL395H, VAL408G, VAL408H