3E50

crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 115
  • Norm. En. per Res.: -3.0559
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-24.1594	-18.0414	-167.839	-210.0399	97	13	0	7740	6	78	75
A-C	-46.0542	4.4355	-81.0548	-122.6735	41	6	1	3057	0	4	5
B-D	-81.733	-5.3119	-264.38	-351.4249	115	17	1	8889	0	16	18

Interface residues

• A-B: ALA161A, ALA403B, ALA419B, ALA452B, ALA881A, ARG164A, ARG423B, ARG460B, ARG49B, ASN528B, ASN52B, ASN979A, ASP163A, ASP175A, ASP416B, ASP60B, ASP876A, ASP935A, CYS171A, GLN129A, GLN167A, GLN407B, GLN412B, GLN883A, GLU126A, GLU133A, GLU159A, GLU277A, GLU404B, GLU408B, GLU413B, GLU447B, GLU448B, GLU457B, GLU458B, GLU529B, GLU536B, GLU59B, GLU875A, GLU879A, GLU880A, GLU934A, GLY160A, GLY405B, GLY51B, HIS134A, HIS157A, HIS53B, ILE50B, ILE531B, ILE54B, ILE874A, ILE937A, LEU173A, LEU274A, LEU455B, LEU456B, LEU524B, LYS119A, LYS120A, LYS123A, LYS273A, LYS327B, LYS415B, LYS527B, LYS56B, LYS872A, LYS884A, LYS933A, LYS938A, LYS941A, MET877A, PHE130A, PHE411B, PHE422B, PHE459B, PHE882A, PRO122A, PRO406B, PRO445B, PRO461B, PRO58B, SER328B, SER57B, SER873A, THR118A, THR451B, THR526B, THR533B, THR55B, THR878A, THR932A, TRP409B, TYR121A, TYR326B, TYR454B, VAL410B
• A-C: ASN329A, ASN376A, ASN418A, ASN605A, CYS414A, GLN363A, GLU341A, GLU365A, GLU453A, GLU612A, GLY331A, GLY335A, GLY339A, GLY342A, GLY361A, GLY362A, HIS332A, HIS336A, HIS340A, HIS4C, ILE338A, ILE374A, ILE375A, LEU334A, LEU337A, LEU347A, LEU359A, LEU613A, LYS364A, LYS436A, PHE372A, PHE373A, PHE5C, SER345A, SER3C, THR358A, TYR333A, TYR609A, VAL1C, VAL2C, VAL360A
• B-D: ALA140B, ALA185B, ARG431B, ARG824B, ASN139B, ASN148B, ASN193B, ASN329B, ASN376B, ASN605B, ASP10D, ASP321B, ASP99B, CYS110B, GLN111B, GLN14D, GLN203B, GLN323B, GLN363B, GLU145B, GLU182B, GLU189B, GLU341B, GLU365B, GLU453B, GLU612B, GLU817B, GLY105B, GLY144B, GLY219B, GLY221B, GLY331B, GLY335B, GLY339B, GLY342B, GLY361B, GLY362B, GLY366B, GLY95B, HIS108B, HIS112B, HIS12D, HIS146B, HIS190B, HIS332B, HIS336B, HIS340B, HIS4D, ILE319B, ILE338B, ILE374B, ILE375B, ILE440B, ILE832B, LEU106B, LEU114B, LEU116B, LEU131B, LEU322B, LEU334B, LEU337B, LEU347B, LEU359B, LEU613B, LEU97B, LYS192B, LYS206B, LYS217B, LYS364B, LYS436B, MET113B, MET371B, PHE109B, PHE115B, PHE141B, PHE168B, PHE202B, PHE218B, PHE372B, PHE373B, PHE5D, PHE820B, PHE834B, SER107B, SER11D, SER128B, SER137B, SER138B, SER143B, SER345B, SER3D, SER435B, SER96B, THR13D, THR142B, THR147B, THR220B, THR358B, THR825B, TRP199B, TYR127B, TYR149B, TYR150B, TYR326B, TYR333B, TYR443B, TYR444B, TYR496B, TYR609B, TYR831B, VAL186B, VAL1D, VAL2D, VAL360B, VAL833B