3E1K

crystal structure of kluyveromyces lactis gal80p in complex with the acidic activation domain of gal4p

• Total interactions analyzed: 120
• Total true interactions: 19
• Strongest Interaction:
  • Chains: M-O
  • Int. Res.: 184
  • Norm. En. per Res.: -3.4928
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-11.112	2.9124	-148.301	-156.5006	74	19	5	7285	0	8	6
A-C	-110.6806	-54.4522	-477.05	-642.1828	190	73	4	21540	4	85	68
A-K	0.0	0.1071	-26.0798	-25.9727	39	6	0	1851	0	9	12
A-M	0.0	-2.2395	-2.8586	-5.0982	20	0	0	366	0	11	8
A-O	-7.3956	-21.8791	-39.9696	-69.2444	25	11	0	2197	2	8	6
C-D	-23.0432	4.0289	-158.43	-177.4443	77	12	5	7266	0	8	6
E-F	-16.6532	2.7527	-151.987	-165.8875	75	16	5	7340	0	7	6
E-G	-147.7981	-53.0659	-455.558	-656.4221	188	55	4	21133	5	83	66
E-I	0.0	10.0095	-3.1388	6.8707	20	0	0	388	0	12	8
E-K	0.0	-15.1087	-31.7798	-46.8885	21	4	0	1900	1	8	5
E-O	0.0	3.1614	-22.2257	-19.0643	40	3	0	1849	0	8	13
G-H	-20.8565	4.1375	-165.654	-182.373	75	12	5	7418	0	8	6
I-J	-28.1138	2.6857	-143.233	-168.6611	76	11	5	7323	0	8	6
I-K	-97.8914	-56.7794	-489.801	-644.4718	186	31	4	20136	8	81	66
K-L	-29.6283	4.097	-155.047	-180.5783	77	12	5	7333	0	9	6
K-O	0.0	51.2395	-141.178	-89.9385	85	9	5	7535	0	30	28
M-N	-45.3546	2.7966	-167.247	-209.805	76	14	5	7358	0	8	6
M-O	-119.481	-33.2388	-489.953	-642.6728	184	33	4	20358	2	85	66
O-P	-23.2098	3.9761	-154.368	-173.6017	76	9	5	7173	0	9	6

Interface residues

• A-B: ALA310A, ARG190A, ARG193A, ARG372A, ASN182A, ASN210A, ASN247A, ASN292A, ASN317A, ASN373A, ASN375A, ASN849B, ASN858B, ASP309A, ASP854B, ASP855B, GLU189A, GLU246A, GLU307A, GLU314A, GLY183A, GLY184A, GLY187A, GLY248A, GLY282A, GLY283A, GLY308A, GLY311A, HIS370A, ILE315A, ILE860B, LEU198A, LEU244A, LEU293A, LEU318A, LEU320A, LEU371A, LEU38A, LEU847B, LYS291A, LYS29A, LYS34A, MET853B, PHE312A, PHE369A, PHE848B, PRO191A, PRO195A, SER194A, SER211A, SER30A, SER316A, SER376A, THR284A, THR35A, THR850B, THR851B, THR852B, TRP185A, TRP31A, TYR158A, TYR186A, TYR199A, TYR321A, TYR374A, TYR857B, TYR859B, VAL286A, VAL313A, VAL319A, VAL368A, VAL377A, VAL378A, VAL856B
• A-C: ALA232A, ALA232C, ARG250A, ARG250C, ASN175A, ASN175C, ASN182A, ASN182C, ASN231A, ASN231C, ASN236A, ASN236C, ASN237A, ASN237C, ASN271A, ASN271C, ASN292A, ASN292C, ASP173A, ASP173C, ASP261A, ASP261C, ASP296A, ASP296C, ASP303A, ASP303C, ASP444A, ASP444C, ASP451A, ASP451C, CYS278A, CYS278C, GLN228A, GLN228C, GLN266A, GLN266C, GLN364A, GLN364C, GLU178A, GLU178C, GLU189A, GLU307A, GLU307C, GLU362A, GLU362C, GLU367A, GLU367C, GLU446A, GLU446C, GLU447A, GLU447C, GLY172C, GLY181A, GLY181C, GLY187A, GLY187C, GLY267A, GLY267C, GLY272A, GLY272C, GLY282A, GLY282C, GLY283A, GLY283C, GLY299A, GLY299C, GLY302A, GLY302C, GLY324A, GLY324C, HIS262A, HIS262C, HIS298A, HIS298C, ILE171A, ILE171C, ILE174A, ILE174C, ILE177A, ILE177C, ILE179A, ILE179C, ILE230A, ILE230C, ILE234A, ILE234C, ILE238A, ILE238C, ILE268A, ILE268C, ILE295A, ILE295C, ILE297A, ILE297C, ILE306A, ILE306C, LEU263A, LEU263C, LEU264A, LEU264C, LEU269A, LEU269C, LEU289A, LEU289C, LEU304A, LEU304C, LEU320A, LEU320C, LEU450A, LEU450C, LYS229A, LYS229C, LYS273A, LYS273C, LYS281A, LYS281C, LYS287A, LYS287C, LYS288A, LYS288C, LYS291A, LYS291C, LYS301A, LYS301C, LYS305A, LYS305C, LYS445A, LYS445C, LYS448A, LYS448C, MET233A, MET233C, MET366A, MET366C, PHE227A, PHE227C, PHE242A, PHE242C, PHE265A, PHE265C, PHE280A, PHE280C, PHE322A, PHE322C, PRO275A, PRO275C, PRO285A, PRO285C, SER176A, SER176C, SER180A, SER180C, SER235A, SER235C, SER277A, SER277C, SER279A, SER279C, SER443A, SER443C, THR284A, THR284C, THR290A, THR290C, THR300A, THR300C, THR365A, THR365C, THR449A, THR449C, TYR186A, TYR186C, TYR188A, TYR188C, TYR321A, TYR321C, TYR323A, TYR323C, VAL274A, VAL274C, VAL276A, VAL276C, VAL286A, VAL286C, VAL294A, VAL294C, VAL368A, VAL368C, VAL440C, VAL452A
• A-K: ALA72K, ARG16K, ARG190A, ARG193A, ARG19K, ASP245A, GLN62A, GLU196A, GLU246A, GLU253A, GLU65K, GLY74K, HIS392K, HIS71K, ILE255A, ILE64K, LEU243A, LEU244A, LEU394K, LEU61K, LEU69K, LYS58A, LYS70K, MET192A, PHE393K, PRO17K, PRO191A, PRO195A, SER14K, SER15K, SER194A, SER256A, SER45K, THR251A, THR254A, THR56A, THR73K, TYR197A, TYR199A
• A-M: ALA72A, ARG16A, ASN327M, ASP173M, GLN68A, GLU168M, GLU362M, GLU363M, GLU65A, GLY328M, HIS71A, ILE325M, ILE64A, LEU69A, LYS301M, LYS326M, LYS70A, SER167M, THR73A, TYR84A
• A-O: ARG250O, ASP76A, GLN241O, GLN62A, GLN66A, GLU253O, GLU65A, GLY74A, ILE255O, ILE64A, LEU243O, LEU57A, LEU61A, LYS252O, LYS58A, PHE242O, PRO239O, SER256O, SER59A, SER60A, THR240O, THR251O, THR254O, THR56A, THR63A
• C-D: ALA310C, ALA33C, ARG190C, ARG193C, ARG372C, ASN182C, ASN210C, ASN247C, ASN292C, ASN317C, ASN373C, ASN375C, ASN849D, ASN858D, ASP309C, ASP854D, ASP855D, GLN241C, GLU189C, GLU246C, GLU307C, GLU314C, GLY181C, GLY183C, GLY184C, GLY187C, GLY248C, GLY282C, GLY283C, GLY308C, GLY311C, HIS370C, ILE315C, ILE860D, LEU198C, LEU244C, LEU293C, LEU318C, LEU320C, LEU371C, LEU38C, LEU847D, LYS291C, LYS29C, LYS34C, MET853D, PHE312C, PHE369C, PHE848D, PRO191C, PRO195C, SER194C, SER211C, SER30C, SER316C, SER376C, THR284C, THR35C, THR850D, THR851D, THR852D, TRP185C, TRP31C, TYR158C, TYR186C, TYR199C, TYR321C, TYR374C, TYR857D, TYR859D, VAL286C, VAL313C, VAL319C, VAL368C, VAL377C, VAL378C, VAL856D
• E-F: ALA310E, ARG190E, ARG193E, ARG372E, ASN182E, ASN210E, ASN247E, ASN292E, ASN317E, ASN373E, ASN375E, ASN849F, ASN858F, ASP309E, ASP854F, ASP855F, GLN241E, GLU189E, GLU246E, GLU307E, GLU314E, GLY183E, GLY184E, GLY187E, GLY248E, GLY282E, GLY283E, GLY308E, GLY311E, HIS370E, ILE315E, ILE860F, LEU198E, LEU244E, LEU293E, LEU318E, LEU320E, LEU371E, LEU38E, LEU847F, LYS291E, LYS29E, LYS34E, MET853F, PHE312E, PHE369E, PHE848F, PRO191E, PRO195E, SER194E, SER211E, SER30E, SER316E, SER376E, THR284E, THR35E, THR850F, THR851F, THR852F, TRP185E, TRP31E, TYR158E, TYR186E, TYR199E, TYR321E, TYR374E, TYR857F, TYR859F, VAL286E, VAL313E, VAL319E, VAL368E, VAL377E, VAL378E, VAL856F
• E-G: ALA232E, ALA232G, ARG250E, ARG250G, ASN175E, ASN175G, ASN182E, ASN182G, ASN231E, ASN231G, ASN236E, ASN236G, ASN237E, ASN237G, ASN271E, ASN271G, ASN292E, ASN292G, ASP173E, ASP173G, ASP261E, ASP261G, ASP296E, ASP296G, ASP303E, ASP303G, ASP444E, ASP444G, ASP451E, ASP451G, CYS278E, CYS278G, GLN228E, GLN266E, GLN266G, GLN364E, GLN364G, GLU178E, GLU178G, GLU189E, GLU307E, GLU307G, GLU362E, GLU362G, GLU367E, GLU367G, GLU446E, GLU446G, GLU447E, GLU447G, GLY172G, GLY181E, GLY181G, GLY187E, GLY187G, GLY267E, GLY267G, GLY272E, GLY272G, GLY282E, GLY282G, GLY283E, GLY283G, GLY299E, GLY299G, GLY302E, GLY302G, GLY324E, GLY324G, HIS262E, HIS262G, HIS298E, HIS298G, ILE171E, ILE171G, ILE174E, ILE174G, ILE177E, ILE177G, ILE179E, ILE179G, ILE230E, ILE230G, ILE234E, ILE234G, ILE238E, ILE238G, ILE268E, ILE268G, ILE295E, ILE295G, ILE297E, ILE297G, ILE306E, ILE306G, LEU263E, LEU263G, LEU264E, LEU264G, LEU269E, LEU269G, LEU289E, LEU289G, LEU304E, LEU304G, LEU320E, LEU320G, LEU450E, LEU450G, LYS229E, LYS229G, LYS273E, LYS273G, LYS281E, LYS281G, LYS287E, LYS287G, LYS288E, LYS288G, LYS291E, LYS291G, LYS301E, LYS301G, LYS305E, LYS305G, LYS445E, LYS445G, LYS448E, LYS448G, MET233E, MET233G, MET366E, MET366G, PHE227E, PHE227G, PHE242E, PHE242G, PHE265E, PHE265G, PHE280E, PHE280G, PHE322E, PHE322G, PRO275E, PRO275G, PRO285E, PRO285G, SER176E, SER176G, SER180E, SER180G, SER235E, SER235G, SER277E, SER277G, SER279E, SER279G, SER443E, SER443G, THR284E, THR284G, THR290E, THR290G, THR300E, THR300G, THR365G, THR449E, THR449G, TYR186E, TYR186G, TYR188E, TYR188G, TYR321E, TYR321G, TYR323E, TYR323G, VAL274E, VAL274G, VAL276E, VAL276G, VAL286E, VAL286G, VAL294E, VAL294G, VAL368E, VAL368G, VAL440E, VAL440G
• E-I: ALA72E, ARG16E, ASN327I, ASP173I, GLN68E, GLU168I, GLU362I, GLU363I, GLU65E, GLY328I, HIS71E, ILE325I, ILE64E, LEU69E, LYS301I, LYS326I, LYS70E, SER167I, THR73E, TYR84E
• E-K: ARG250K, ASP76E, GLN241K, GLN62E, GLN66E, GLU253K, GLU65E, ILE255K, LEU57E, LEU61E, LYS249K, LYS252K, LYS58E, PHE242K, PRO239K, SER59E, THR240K, THR251K, THR254K, THR56E, THR63E
• E-O: ALA72O, ARG16O, ARG190E, ARG193E, ARG19O, ASP245E, GLN62E, GLN66E, GLU196E, GLU246E, GLU253E, GLY74O, HIS392O, HIS71O, ILE255E, ILE64O, LEU198E, LEU243E, LEU244E, LEU394O, LEU61O, LEU69O, LYS29E, LYS58E, LYS70O, MET192E, PHE393O, PRO17O, PRO191E, PRO195E, SER14O, SER15O, SER194E, SER45O, THR251E, THR254E, THR56E, THR73O, TYR197E, TYR199E
• G-H: ALA310G, ARG190G, ARG193G, ARG372G, ASN182G, ASN210G, ASN247G, ASN292G, ASN317G, ASN373G, ASN375G, ASN849H, ASN858H, ASP309G, ASP854H, ASP855H, GLU189G, GLU246G, GLU307G, GLU314G, GLY181G, GLY183G, GLY184G, GLY187G, GLY248G, GLY282G, GLY283G, GLY308G, GLY311G, HIS370G, ILE315G, ILE860H, LEU198G, LEU244G, LEU293G, LEU318G, LEU320G, LEU371G, LEU38G, LEU847H, LYS287G, LYS291G, LYS34G, MET853H, PHE312G, PHE369G, PHE848H, PRO191G, PRO195G, SER194G, SER30G, SER316G, SER376G, THR284G, THR35G, THR850H, THR851H, THR852H, TRP185G, TRP31G, TYR158G, TYR186G, TYR197G, TYR199G, TYR321G, TYR374G, TYR857H, TYR859H, VAL286G, VAL313G, VAL319G, VAL368G, VAL377G, VAL378G, VAL856H
• I-J: ALA310I, ARG190I, ARG193I, ARG372I, ASN182I, ASN210I, ASN247I, ASN292I, ASN317I, ASN373I, ASN375I, ASN380I, ASN849J, ASN858J, ASP309I, ASP854J, ASP855J, GLN241I, GLU189I, GLU246I, GLU307I, GLY183I, GLY184I, GLY187I, GLY248I, GLY282I, GLY283I, GLY308I, GLY311I, GLY379I, HIS370I, ILE315I, ILE860J, LEU198I, LEU244I, LEU293I, LEU318I, LEU320I, LEU371I, LEU38I, LEU847J, LYS291I, LYS29I, LYS34I, MET853J, PHE312I, PHE369I, PHE848J, PRO191I, PRO195I, SER194I, SER30I, SER316I, SER376I, THR284I, THR35I, THR850J, THR851J, THR852J, TRP185I, TRP31I, TYR158I, TYR186I, TYR197I, TYR199I, TYR321I, TYR374I, TYR857J, TYR859J, VAL286I, VAL313I, VAL319I, VAL368I, VAL377I, VAL378I, VAL856J
• I-K: ALA232I, ALA232K, ARG250I, ARG250K, ASN175I, ASN175K, ASN182I, ASN182K, ASN231I, ASN231K, ASN236I, ASN236K, ASN237I, ASN237K, ASN271I, ASN271K, ASN292I, ASN292K, ASP173I, ASP173K, ASP261I, ASP261K, ASP296I, ASP296K, ASP303I, ASP303K, ASP444I, ASP444K, ASP451I, ASP451K, CYS278I, CYS278K, GLN228K, GLN266I, GLN266K, GLN364I, GLN364K, GLU178I, GLU178K, GLU307I, GLU307K, GLU362I, GLU362K, GLU367I, GLU367K, GLU446I, GLU446K, GLU447I, GLU447K, GLY172K, GLY181I, GLY181K, GLY187I, GLY187K, GLY267I, GLY267K, GLY272I, GLY272K, GLY282I, GLY282K, GLY283I, GLY283K, GLY299I, GLY299K, GLY302I, GLY302K, GLY324I, GLY324K, HIS262I, HIS262K, HIS298I, HIS298K, ILE171I, ILE171K, ILE174I, ILE174K, ILE177I, ILE177K, ILE179I, ILE179K, ILE230I, ILE230K, ILE234I, ILE234K, ILE238I, ILE238K, ILE268I, ILE268K, ILE295I, ILE295K, ILE297I, ILE297K, ILE306I, ILE306K, LEU263I, LEU263K, LEU264I, LEU264K, LEU269I, LEU269K, LEU289I, LEU289K, LEU304I, LEU304K, LEU320I, LEU320K, LEU450I, LEU450K, LYS229I, LYS229K, LYS273I, LYS273K, LYS281I, LYS281K, LYS287I, LYS287K, LYS288I, LYS288K, LYS291I, LYS291K, LYS301I, LYS301K, LYS305I, LYS305K, LYS445I, LYS445K, LYS448I, LYS448K, MET233I, MET233K, MET366I, MET366K, PHE227I, PHE227K, PHE242I, PHE242K, PHE265I, PHE265K, PHE280I, PHE280K, PHE322I, PHE322K, PRO275I, PRO275K, PRO285I, PRO285K, SER176I, SER176K, SER180I, SER180K, SER235I, SER235K, SER277I, SER277K, SER279I, SER279K, SER443I, SER443K, THR284I, THR284K, THR290I, THR290K, THR300I, THR300K, THR449I, THR449K, TYR186I, TYR186K, TYR188I, TYR188K, TYR321I, TYR321K, TYR323I, TYR323K, VAL274I, VAL274K, VAL276I, VAL276K, VAL286I, VAL286K, VAL294I, VAL294K, VAL368I, VAL368K, VAL440I, VAL440K
• K-L: ALA310K, ARG190K, ARG193K, ARG372K, ASN182K, ASN210K, ASN247K, ASN292K, ASN317K, ASN373K, ASN375K, ASN849L, ASN858L, ASP309K, ASP854L, ASP855L, GLN241K, GLU189K, GLU246K, GLU307K, GLU314K, GLY181K, GLY183K, GLY184K, GLY187K, GLY248K, GLY282K, GLY283K, GLY308K, GLY311K, HIS370K, ILE315K, ILE860L, LEU198K, LEU244K, LEU293K, LEU318K, LEU320K, LEU371K, LEU38K, LEU847L, LYS281K, LYS291K, LYS34K, MET853L, PHE312K, PHE369K, PHE848L, PRO191K, PRO195K, SER194K, SER211K, SER30K, SER316K, SER376K, THR284K, THR35K, THR850L, THR851L, THR852L, TRP185K, TRP31K, TYR158K, TYR186K, TYR197K, TYR199K, TYR321K, TYR374K, TYR857L, TYR859L, VAL286K, VAL313K, VAL319K, VAL368K, VAL377K, VAL378K, VAL856L
• K-O: ALA72K, ALA72O, ARG190K, ARG190O, ARG193K, ARG193O, ARG250K, ARG250O, ASN247K, ASP245K, ASP245O, ASP76K, ASP76O, GLN241K, GLN241O, GLN62K, GLN62O, GLN66K, GLN66O, GLN68K, GLN68O, GLU196K, GLU196O, GLU246K, GLU246O, GLU253K, GLU253O, GLU65K, GLU65O, GLY74K, GLY74O, ILE255K, ILE255O, ILE64K, ILE64O, LEU198K, LEU198O, LEU243K, LEU243O, LEU244K, LEU244O, LEU57K, LEU57O, LEU61K, LEU61O, LEU69K, LEU69O, LYS249K, LYS249O, LYS252K, LYS252O, LYS58K, LYS58O, LYS95O, MET192K, MET192O, PRO191K, PRO191O, PRO195K, PRO195O, PRO55K, PRO55O, SER194K, SER194O, SER256K, SER256O, SER27O, SER59K, SER59O, SER60K, SER60O, THR251K, THR251O, THR254K, THR254O, THR56K, THR56O, THR63K, THR63O, THR73K, THR73O, TYR197K, TYR197O, TYR199K, TYR199O
• M-N: ALA310M, ARG190M, ARG193M, ARG372M, ASN182M, ASN210M, ASN247M, ASN292M, ASN317M, ASN373M, ASN375M, ASN849N, ASN858N, ASP309M, ASP854N, ASP855N, GLN241M, GLU189M, GLU246M, GLU307M, GLY183M, GLY184M, GLY187M, GLY248M, GLY282M, GLY283M, GLY308M, GLY311M, HIS370M, ILE315M, ILE860N, LEU198M, LEU244M, LEU293M, LEU318M, LEU320M, LEU371M, LEU38M, LEU847N, LYS291M, LYS29M, LYS34M, MET853N, PHE280M, PHE312M, PHE369M, PHE848N, PRO191M, PRO195M, SER194M, SER211M, SER30M, SER316M, SER376M, THR284M, THR35M, THR850N, THR851N, THR852N, TRP185M, TRP31M, TYR158M, TYR186M, TYR197M, TYR199M, TYR321M, TYR374M, TYR857N, TYR859N, VAL286M, VAL313M, VAL319M, VAL368M, VAL377M, VAL378M, VAL856N
• M-O: ALA232M, ALA232O, ARG250M, ARG250O, ASN175M, ASN175O, ASN182M, ASN182O, ASN231M, ASN231O, ASN236M, ASN236O, ASN237M, ASN237O, ASN271M, ASN271O, ASN292M, ASN292O, ASP173M, ASP173O, ASP261M, ASP261O, ASP296M, ASP296O, ASP303M, ASP303O, ASP444M, ASP444O, ASP451M, ASP451O, CYS278M, CYS278O, GLN266M, GLN266O, GLN364M, GLN364O, GLU178M, GLU178O, GLU307M, GLU307O, GLU362M, GLU362O, GLU367M, GLU367O, GLU446M, GLU446O, GLU447M, GLU447O, GLY172O, GLY181M, GLY181O, GLY187M, GLY187O, GLY267M, GLY267O, GLY272M, GLY272O, GLY282M, GLY282O, GLY283M, GLY283O, GLY299M, GLY299O, GLY302M, GLY302O, GLY324M, GLY324O, HIS262M, HIS262O, HIS298M, HIS298O, ILE171M, ILE171O, ILE174M, ILE174O, ILE177M, ILE177O, ILE179M, ILE179O, ILE230M, ILE230O, ILE234M, ILE234O, ILE238M, ILE238O, ILE268M, ILE268O, ILE295M, ILE295O, ILE297M, ILE297O, ILE306M, ILE306O, LEU263M, LEU263O, LEU264M, LEU264O, LEU269M, LEU269O, LEU289M, LEU289O, LEU304M, LEU304O, LEU320M, LEU320O, LEU450M, LEU450O, LYS229M, LYS229O, LYS273M, LYS273O, LYS281M, LYS281O, LYS287M, LYS287O, LYS288M, LYS288O, LYS291M, LYS291O, LYS301M, LYS301O, LYS305M, LYS305O, LYS445M, LYS448M, LYS448O, MET233M, MET233O, MET366M, MET366O, PHE227M, PHE227O, PHE242M, PHE265M, PHE265O, PHE280M, PHE280O, PHE322M, PHE322O, PRO275M, PRO275O, PRO285M, PRO285O, SER176M, SER176O, SER180M, SER180O, SER235M, SER235O, SER277M, SER277O, SER279M, SER279O, SER443M, SER443O, THR284M, THR284O, THR290M, THR290O, THR300M, THR300O, THR365O, THR449M, THR449O, TYR186M, TYR186O, TYR188M, TYR188O, TYR321M, TYR321O, TYR323M, TYR323O, VAL274M, VAL274O, VAL276M, VAL276O, VAL286M, VAL286O, VAL294M, VAL294O, VAL368M, VAL368O, VAL440M, VAL440O
• O-P: ALA310O, ARG190O, ARG193O, ARG372O, ASN182O, ASN210O, ASN247O, ASN292O, ASN317O, ASN373O, ASN375O, ASN849P, ASN858P, ASP309O, ASP854P, ASP855P, GLU189O, GLU246O, GLU307O, GLU314O, GLY181O, GLY183O, GLY184O, GLY187O, GLY248O, GLY282O, GLY283O, GLY308O, GLY311O, HIS370O, ILE315O, ILE860P, LEU198O, LEU244O, LEU293O, LEU318O, LEU320O, LEU371O, LEU38O, LEU847P, LYS287O, LYS291O, LYS29O, LYS34O, MET853P, PHE312O, PHE369O, PHE848P, PRO191O, PRO195O, SER194O, SER211O, SER30O, SER316O, SER376O, THR284O, THR35O, THR850P, THR851P, THR852P, TRP185O, TRP31O, TYR158O, TYR186O, TYR199O, TYR321O, TYR374O, TYR857P, TYR859P, VAL286O, VAL313O, VAL319O, VAL368O, VAL377O, VAL378O, VAL856P