3E08

h55s mutant xanthomonas campestris tryptophan 2,3- dioxygenase

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 314
  • Norm. En. per Res.: -5.4665
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-287.9376	-168.548	-1235.33	-1691.8156	313	51	23	50646	16	76	64
A-C	0.0	26.269	-74.4927	-48.2237	52	2	0	2979	0	41	25
A-D	-31.7482	-60.7961	-458.217	-550.7613	163	16	1	18358	6	48	60
A-F	-13.1221	-2.9218	-28.0126	-44.0566	43	3	0	1569	0	11	6
A-H	-3.007	-7.2976	-64.4685	-74.7731	47	9	1	4105	2	19	17
B-C	-30.8039	-85.6723	-449.221	-565.6972	165	11	1	18081	6	48	61
B-D	0.0	25.2931	-92.8353	-67.5422	51	3	0	3463	0	41	25
B-F	-12.9409	-5.5602	-78.6715	-97.1727	44	8	1	3664	1	19	16
B-H	-5.5899	-7.4395	-31.9395	-44.9689	43	1	0	1700	0	9	6
C-D	-232.4505	-158.9057	-1292.76	-1684.1162	315	39	22	51753	17	76	59
E-F	-262.0142	-147.8634	-1306.61	-1716.4876	314	52	23	51904	16	78	57
E-G	0.0	24.5683	-64.4696	-39.9012	48	1	0	2779	0	37	22
E-H	-21.5233	-73.6577	-413.269	-508.45	153	10	1	16753	6	42	50
F-G	-23.5585	-72.2906	-399.979	-495.8281	151	9	1	16143	6	42	50
F-H	0.0	26.9399	-90.7453	-63.8054	50	3	0	3345	1	38	24
G-H	-250.0963	-158.6229	-1286.6	-1695.3193	314	41	22	51574	17	78	61

Interface residues

• A-B: ALA150A, ALA150B, ALA195A, ALA195B, ALA198A, ALA198B, ALA266A, ALA266B, ALA268A, ALA268B, ALA36A, ALA36B, ALA44A, ALA44B, ALA66A, ALA66B, ALA71A, ALA71B, ALA72A, ALA72B, ALA89A, ALA89B, ARG117A, ARG117B, ARG132A, ARG132B, ARG158A, ARG158B, ARG21A, ARG21B, ARG237A, ARG237B, ARG239A, ARG239B, ARG246A, ARG246B, ARG252A, ARG252B, ARG29A, ARG29B, ARG70A, ARG70B, ARG8A, ARG8B, ARG90A, ARG90B, ARG96A, ARG96B, ASN140A, ASN140B, ASN142A, ASN142B, ASP118A, ASP118B, ASP152A, ASP152B, ASP17A, ASP17B, ASP31A, ASP31B, ASP47A, ASP47B, ASP9A, ASP9B, GLN101A, GLN101B, GLN127A, GLN127B, GLN130A, GLN130B, GLN144A, GLN144B, GLN147A, GLN147B, GLN264A, GLN264B, GLN265A, GLN265B, GLN32A, GLN32B, GLN37A, GLN37B, GLN38A, GLN38B, GLN54A, GLN54B, GLN56A, GLN56B, GLN93A, GLN93B, GLN97A, GLN97B, GLU100A, GLU100B, GLU106A, GLU106B, GLU112A, GLU112B, GLU11A, GLU11B, GLU135A, GLU135B, GLU19A, GLU19B, GLU48A, GLU48B, GLU59A, GLU59B, GLU68A, GLU68B, GLY121A, GLY121B, GLY125A, GLY125B, GLY139A, GLY139B, GLY13A, GLY13B, GLY20A, GLY20B, GLY253A, GLY253B, GLY255A, GLY255B, GLY256A, GLY256B, GLY259A, GLY259B, GLY25A, GLY25B, GLY261A, GLY261B, GLY26A, GLY26B, HIS15A, HIS15B, HIS196A, HIS196B, HIS240A, HIS45A, HIS45B, HIS46A, HIS46B, HIS67A, HIS67B, HIS75A, HIS75B, ILE14A, ILE14B, ILE52A, ILE52B, ILE53A, ILE53B, LEU105A, LEU105B, LEU108A, LEU108B, LEU10A, LEU10B, LEU120A, LEU120B, LEU129A, LEU129B, LEU146A, LEU146B, LEU18A, LEU18B, LEU22A, LEU22B, LEU263A, LEU263B, LEU267A, LEU267B, LEU269A, LEU269B, LEU28A, LEU28B, LEU30A, LEU30B, LEU33A, LEU33B, LEU34A, LEU34B, LEU40A, LEU40B, LEU50A, LEU50B, LEU60A, LEU60B, LEU62A, LEU62B, LEU64A, LEU64B, LEU65A, LEU65B, LEU69A, LEU69B, LEU7A, LEU7B, LEU88A, LEU88B, LEU95A, LEU95B, LEU98A, LEU98B, LYS141A, LYS141B, LYS63A, LYS63B, LYS86A, LYS86B, LYS92A, LYS92B, MET145A, MET145B, MET49A, MET49B, PHE116A, PHE116B, PHE126A, PHE126B, PHE149A, PHE149B, PHE262A, PHE262B, PHE271A, PHE271B, PHE51A, PHE51B, PRO110A, PRO122A, PRO122B, PRO12A, PRO12B, PRO143A, PRO143B, PRO153A, PRO153B, PRO273A, PRO273B, PRO39A, PRO39B, SER103A, SER103B, SER111A, SER111B, SER123A, SER123B, SER124A, SER124B, SER128A, SER128B, SER257A, SER257B, SER258A, SER258B, SER35A, SER35B, SER41A, SER41B, SER55A, SER55B, SER58A, SER58B, SER91A, SER91B, THR107A, THR107B, THR109A, THR109B, THR16A, THR16B, THR23A, THR23B, THR254A, THR254B, THR270A, THR270B, THR57A, THR57B, THR99A, THR99B, TRP102A, TRP102B, TRP236A, TRP61A, TRP61B, TRP82A, TRP82B, TYR113A, TYR113B, TYR131A, TYR131B, TYR151A, TYR151B, TYR24A, TYR24B, TYR27A, TYR27B, VAL104A, VAL104B, VAL119A, VAL119B, VAL148A, VAL148B, VAL197A, VAL197B, VAL260A, VAL260B, VAL87A, VAL87B, VAL94A, VAL94B
• A-C: ALA89A, ALA89C, ARG215A, ARG215C, ARG218A, ARG218C, ARG85A, ARG85C, ARG90A, ARG90C, ARG96A, ARG96C, ASN212A, ASN212C, ASP214A, ASP214C, ASP285A, ASP285C, GLN232A, GLN232C, GLN83A, GLN83C, GLN93A, GLN93C, GLN97A, GLN97C, GLU100A, GLU100C, GLU224A, GLU224C, GLU80A, GLU80C, HIS75A, HIS75C, LYS86A, LYS86C, LYS92A, LYS92C, SER221A, SER221C, THR213A, THR213C, TRP217A, TRP217C, TRP82A, TRP82C, TYR210A, TYR216A, TYR216C, TYR220A, TYR220C, VAL81A
• A-D: ALA266A, ALA266D, ALA268A, ALA268D, ARG117A, ARG117D, ARG203A, ARG237A, ARG237D, ARG239A, ARG239D, ARG242A, ARG242D, ARG246A, ARG246D, ARG252A, ARG252D, ARG279A, ARG279D, ARG96A, ARG96D, ASN212A, ASN212D, ASN286A, ASN286D, ASP118D, ASP225A, ASP225D, ASP228A, ASP228D, ASP277A, ASP277D, ASP285A, ASP285D, ASP47D, CYS223A, CYS223D, GLN232A, GLN232D, GLN234A, GLN234D, GLN264A, GLN264D, GLU100A, GLU100D, GLU106A, GLU106D, GLU112A, GLU112D, GLU207A, GLU207D, GLU211A, GLU211D, GLU224A, GLU224D, GLU230A, GLU230D, GLY115A, GLY115D, GLY249A, GLY249D, GLY283A, GLY283D, HIS240A, HIS240D, HIS45A, HIS45D, ILE209A, ILE209D, ILE248A, ILE248D, LEU108A, LEU108D, LEU226A, LEU226D, LEU235A, LEU235D, LEU267A, LEU267D, LEU269A, LEU269D, LEU275A, LEU275D, LYS251A, LYS251D, LYS92A, LYS92D, MET114A, MET114D, MET241A, MET241D, MET245A, MET245D, PHE116A, PHE116D, PHE206A, PHE206D, PHE233A, PHE233D, PHE238A, PHE238D, PHE250A, PHE250D, PHE271A, PHE271D, PHE272A, PHE272D, PHE276A, PHE276D, PRO110A, PRO110D, PRO273A, PRO273D, SER103A, SER103D, SER111A, SER111D, SER221A, SER221D, SER281A, SER281D, THR107A, THR107D, THR109A, THR109D, THR213A, THR213D, THR231A, THR231D, THR243A, THR243D, THR270A, THR270D, THR280A, THR280D, THR99A, THR99D, TRP102A, TRP102D, TRP236A, TRP236D, TYR113A, TYR113D, TYR210A, TYR210D, TYR220A, TYR220D, VAL227A, VAL227D, VAL229A, VAL229D, VAL244A, VAL244D, VAL247A, VAL247D, VAL260A, VAL260D, VAL278A, VAL278D, VAL282A, VAL282D, VAL284A, VAL284D
• A-F: ALA154A, ALA177F, ALA182F, ALA36A, ALA44A, ARG174F, ARG178F, ARG208F, ARG215F, ARG218F, ARG78F, ASN212F, ASP152A, ASP214F, ASP79F, GLN185F, GLN188F, GLN32A, GLN37A, GLN38A, GLN77F, GLU219F, GLU42A, GLU48A, GLU80F, GLY121A, GLY180F, HIS181F, ILE52A, LEU120A, LEU40A, MET49A, PHE179F, PRO122A, PRO153A, PRO204F, PRO39A, SER35A, SER41A, TRP217F, TYR151A, TYR216F, VAL119A
• A-H: ALA177H, ALA189H, ARG174H, ARG178H, ARG208H, ARG215H, ARG218H, ARG21A, ARG29A, ARG78H, ASP17A, ASP31A, ASP79H, GLN185H, GLN188H, GLN32A, GLN77H, GLU171H, GLU19A, GLU219H, GLU80H, GLY180H, GLY20A, GLY25A, GLY26A, HIS181H, ILE183H, LEU173H, LEU176H, LEU18A, LEU22A, LEU28A, LEU30A, LEU33A, PHE179H, PRO166H, PRO184H, SER35A, THR23A, TRP192H, TRP217H, TYR175H, TYR187H, TYR216H, TYR24A, TYR27A, VAL81H
• B-C: ALA266B, ALA266C, ALA268B, ALA268C, ARG117B, ARG117C, ARG203B, ARG203C, ARG237B, ARG237C, ARG239B, ARG239C, ARG242B, ARG242C, ARG246B, ARG246C, ARG252B, ARG252C, ARG279B, ARG279C, ARG96B, ARG96C, ASN212B, ASN212C, ASN286B, ASN286C, ASP118B, ASP118C, ASP225B, ASP225C, ASP228B, ASP228C, ASP277B, ASP277C, ASP285B, ASP285C, ASP47C, CYS223B, CYS223C, GLN232B, GLN232C, GLN234B, GLN234C, GLN264B, GLN264C, GLU100B, GLU100C, GLU106B, GLU106C, GLU112B, GLU112C, GLU207B, GLU207C, GLU211B, GLU211C, GLU224B, GLU224C, GLU230B, GLU230C, GLY115B, GLY115C, GLY249B, GLY249C, GLY283B, GLY283C, HIS240B, HIS240C, HIS45B, HIS45C, ILE209B, ILE209C, ILE248B, ILE248C, LEU108B, LEU108C, LEU226B, LEU226C, LEU235B, LEU235C, LEU267B, LEU267C, LEU269B, LEU269C, LEU275B, LEU275C, LYS251B, LYS251C, LYS92B, LYS92C, MET114B, MET114C, MET241B, MET241C, MET245B, MET245C, PHE116B, PHE116C, PHE206B, PHE206C, PHE233B, PHE233C, PHE238B, PHE238C, PHE250B, PHE250C, PHE271B, PHE271C, PHE272B, PHE272C, PHE276B, PHE276C, PRO110B, PRO110C, PRO273B, PRO273C, SER103B, SER103C, SER111B, SER111C, SER221B, SER221C, SER281B, SER281C, THR107B, THR107C, THR109B, THR109C, THR213B, THR213C, THR231B, THR231C, THR243B, THR243C, THR270B, THR270C, THR280B, THR280C, THR99B, THR99C, TRP102B, TRP102C, TRP236B, TRP236C, TYR113B, TYR113C, TYR210B, TYR210C, TYR220B, TYR220C, VAL227B, VAL227C, VAL229B, VAL229C, VAL244B, VAL244C, VAL247B, VAL247C, VAL260B, VAL260C, VAL278B, VAL278C, VAL282B, VAL282C, VAL284B, VAL284C
• B-D: ALA89B, ALA89D, ARG215B, ARG215D, ARG218B, ARG218D, ARG85B, ARG85D, ARG90B, ARG90D, ARG96B, ARG96D, ASN212B, ASN212D, ASP214B, ASP214D, ASP285B, ASP285D, GLN232D, GLN83B, GLN83D, GLN93B, GLN93D, GLN97B, GLN97D, GLU100B, GLU100D, GLU224B, GLU224D, GLU80B, GLU80D, HIS75B, HIS75D, LYS86B, LYS86D, LYS92B, LYS92D, SER221B, SER221D, THR213B, THR213D, TRP217B, TRP217D, TRP82B, TRP82D, TYR216B, TYR216D, TYR220B, TYR220D, VAL81B, VAL81D
• B-F: ALA177F, ALA189F, ARG174F, ARG178F, ARG208F, ARG215F, ARG218F, ARG21B, ARG29B, ARG78F, ASP17B, ASP31B, ASP79F, GLN185F, GLN188F, GLN32B, GLN77F, GLU171F, GLU19B, GLU219F, GLU80F, GLY180F, GLY20B, GLY25B, GLY26B, HIS181F, ILE183F, LEU173F, LEU176F, LEU18B, LEU22B, LEU28B, LEU30B, PHE179F, PRO184F, SER35B, THR23B, TRP192F, TRP217F, TYR175F, TYR187F, TYR216F, TYR27B, VAL81F
• B-H: ALA154B, ALA177H, ALA182H, ALA36B, ALA44B, ARG174H, ARG178H, ARG208H, ARG215H, ARG218H, ARG78H, ASP152B, ASP214H, ASP79H, GLN185H, GLN188H, GLN32B, GLN37B, GLN38B, GLN77H, GLU219H, GLU42B, GLU48B, GLU80H, GLY155B, GLY180H, HIS181H, ILE52B, LEU120B, LEU40B, MET49B, PHE179H, PRO122B, PRO153B, PRO39B, SER123B, SER35B, SER41B, TRP217H, TYR151B, TYR216H, VAL119B, VAL74H
• C-D: ALA150C, ALA150D, ALA195C, ALA195D, ALA198C, ALA198D, ALA266C, ALA266D, ALA268C, ALA268D, ALA36C, ALA36D, ALA44C, ALA44D, ALA66C, ALA66D, ALA71C, ALA71D, ALA72C, ALA72D, ALA89C, ALA89D, ARG117C, ARG117D, ARG132C, ARG132D, ARG158C, ARG158D, ARG21C, ARG21D, ARG237C, ARG237D, ARG239C, ARG239D, ARG246C, ARG246D, ARG252C, ARG252D, ARG29C, ARG29D, ARG70C, ARG70D, ARG8C, ARG8D, ARG90C, ARG90D, ARG96C, ARG96D, ASN140C, ASN140D, ASN142C, ASN142D, ASP118C, ASP118D, ASP152C, ASP152D, ASP17C, ASP17D, ASP31C, ASP31D, ASP47C, ASP47D, ASP9C, ASP9D, GLN101C, GLN101D, GLN127C, GLN127D, GLN130C, GLN130D, GLN144C, GLN144D, GLN147C, GLN147D, GLN264C, GLN264D, GLN265C, GLN265D, GLN32C, GLN32D, GLN37C, GLN37D, GLN38C, GLN38D, GLN54C, GLN54D, GLN56C, GLN56D, GLN93C, GLN93D, GLN97C, GLN97D, GLU100C, GLU100D, GLU106C, GLU106D, GLU112C, GLU112D, GLU11C, GLU11D, GLU135C, GLU135D, GLU19C, GLU19D, GLU48C, GLU48D, GLU59C, GLU59D, GLU68C, GLU68D, GLY121C, GLY121D, GLY125C, GLY125D, GLY139C, GLY139D, GLY13C, GLY13D, GLY20C, GLY20D, GLY253C, GLY253D, GLY255C, GLY255D, GLY256C, GLY256D, GLY259C, GLY259D, GLY25C, GLY25D, GLY261C, GLY261D, GLY26C, GLY26D, HIS15C, HIS15D, HIS196C, HIS196D, HIS240C, HIS240D, HIS45C, HIS45D, HIS46C, HIS46D, HIS67C, HIS67D, HIS75C, HIS75D, ILE14C, ILE14D, ILE52C, ILE52D, ILE53C, ILE53D, LEU105C, LEU105D, LEU108C, LEU108D, LEU10C, LEU10D, LEU120C, LEU120D, LEU129C, LEU129D, LEU146C, LEU146D, LEU18C, LEU18D, LEU22C, LEU22D, LEU263C, LEU263D, LEU267C, LEU267D, LEU269C, LEU269D, LEU28C, LEU28D, LEU30C, LEU30D, LEU33C, LEU33D, LEU34C, LEU34D, LEU40C, LEU40D, LEU50C, LEU50D, LEU60C, LEU60D, LEU62C, LEU62D, LEU64C, LEU64D, LEU65C, LEU65D, LEU69C, LEU69D, LEU7C, LEU7D, LEU88C, LEU88D, LEU95C, LEU95D, LEU98C, LEU98D, LYS141C, LYS141D, LYS63C, LYS63D, LYS86C, LYS86D, LYS92C, LYS92D, MET145C, MET145D, MET49C, MET49D, PHE116C, PHE116D, PHE126C, PHE126D, PHE136C, PHE149C, PHE149D, PHE262C, PHE262D, PHE271C, PHE271D, PHE51C, PHE51D, PRO122C, PRO122D, PRO12C, PRO12D, PRO143C, PRO143D, PRO153C, PRO153D, PRO273C, PRO273D, PRO39C, PRO39D, SER103C, SER103D, SER111C, SER111D, SER123C, SER123D, SER124C, SER124D, SER128C, SER128D, SER257C, SER257D, SER258C, SER258D, SER35C, SER35D, SER41C, SER41D, SER55C, SER55D, SER58C, SER58D, SER91C, SER91D, THR107C, THR107D, THR109C, THR109D, THR16C, THR16D, THR23C, THR23D, THR254C, THR254D, THR270C, THR270D, THR57C, THR57D, THR99C, THR99D, TRP102C, TRP102D, TRP236C, TRP236D, TRP61C, TRP61D, TRP82C, TRP82D, TYR113C, TYR113D, TYR131C, TYR131D, TYR151C, TYR151D, TYR24C, TYR24D, TYR27C, TYR27D, VAL104C, VAL104D, VAL119C, VAL119D, VAL148C, VAL148D, VAL197C, VAL197D, VAL260C, VAL260D, VAL87C, VAL87D, VAL94C, VAL94D
• E-F: ALA150E, ALA150F, ALA195E, ALA195F, ALA198E, ALA198F, ALA266E, ALA266F, ALA268E, ALA268F, ALA36E, ALA36F, ALA44E, ALA44F, ALA66E, ALA66F, ALA71E, ALA71F, ALA72E, ALA72F, ALA89E, ALA89F, ARG117E, ARG132E, ARG132F, ARG158E, ARG158F, ARG21E, ARG21F, ARG237E, ARG237F, ARG239E, ARG239F, ARG246E, ARG246F, ARG252E, ARG252F, ARG29E, ARG29F, ARG70E, ARG70F, ARG8E, ARG8F, ARG90E, ARG90F, ARG96E, ARG96F, ASN140E, ASN140F, ASN142E, ASN142F, ASP118E, ASP118F, ASP152E, ASP152F, ASP17E, ASP17F, ASP31E, ASP31F, ASP47E, ASP47F, ASP9E, ASP9F, GLN101E, GLN101F, GLN127E, GLN127F, GLN130E, GLN130F, GLN144E, GLN144F, GLN147E, GLN147F, GLN264E, GLN264F, GLN265E, GLN265F, GLN32E, GLN32F, GLN37E, GLN37F, GLN38E, GLN38F, GLN54E, GLN54F, GLN56E, GLN56F, GLN93E, GLN93F, GLN97E, GLN97F, GLU100E, GLU100F, GLU106E, GLU106F, GLU112E, GLU112F, GLU11E, GLU11F, GLU135E, GLU135F, GLU19E, GLU19F, GLU48E, GLU48F, GLU59E, GLU59F, GLU68E, GLU68F, GLY121E, GLY121F, GLY125E, GLY125F, GLY139E, GLY139F, GLY13E, GLY13F, GLY20E, GLY20F, GLY253E, GLY253F, GLY255E, GLY255F, GLY256E, GLY256F, GLY259E, GLY259F, GLY25E, GLY25F, GLY261E, GLY261F, GLY26E, GLY26F, HIS15E, HIS15F, HIS196E, HIS196F, HIS45E, HIS45F, HIS46E, HIS46F, HIS67E, HIS67F, HIS75E, HIS75F, ILE14E, ILE14F, ILE52E, ILE52F, ILE53E, ILE53F, LEU105E, LEU105F, LEU108E, LEU108F, LEU10E, LEU10F, LEU120E, LEU120F, LEU129E, LEU129F, LEU146E, LEU146F, LEU18E, LEU18F, LEU22E, LEU22F, LEU263E, LEU263F, LEU267E, LEU267F, LEU269E, LEU269F, LEU28E, LEU28F, LEU30E, LEU30F, LEU33E, LEU33F, LEU34E, LEU34F, LEU40E, LEU40F, LEU50E, LEU50F, LEU60E, LEU60F, LEU62E, LEU62F, LEU64E, LEU64F, LEU65E, LEU65F, LEU69E, LEU69F, LEU7E, LEU7F, LEU88E, LEU88F, LEU95E, LEU95F, LEU98E, LEU98F, LYS141E, LYS141F, LYS63E, LYS63F, LYS86E, LYS86F, LYS92E, LYS92F, MET145E, MET145F, MET49E, MET49F, PHE116E, PHE116F, PHE126E, PHE126F, PHE136E, PHE149E, PHE149F, PHE262E, PHE262F, PHE271E, PHE271F, PHE51E, PHE51F, PRO110E, PRO110F, PRO122E, PRO122F, PRO12E, PRO12F, PRO143E, PRO143F, PRO153E, PRO153F, PRO273E, PRO273F, PRO39E, PRO39F, SER103E, SER103F, SER111E, SER111F, SER123E, SER123F, SER124E, SER124F, SER128E, SER128F, SER257E, SER257F, SER258E, SER258F, SER35E, SER35F, SER41E, SER41F, SER55E, SER55F, SER58E, SER58F, SER91E, SER91F, THR107E, THR107F, THR109E, THR109F, THR16E, THR16F, THR23E, THR23F, THR254E, THR254F, THR270E, THR270F, THR57E, THR57F, THR99E, THR99F, TRP102E, TRP102F, TRP236E, TRP236F, TRP61E, TRP61F, TRP82E, TRP82F, TYR113E, TYR113F, TYR131E, TYR131F, TYR151E, TYR151F, TYR24E, TYR24F, TYR27E, TYR27F, VAL104E, VAL104F, VAL119E, VAL119F, VAL148E, VAL148F, VAL197E, VAL197F, VAL260E, VAL260F, VAL87E, VAL87F, VAL94E, VAL94F
• E-G: ALA89E, ALA89G, ARG215E, ARG215G, ARG218E, ARG218G, ARG85E, ARG85G, ARG90E, ARG90G, ARG96E, ARG96G, ASN212E, ASN212G, ASP214E, ASP214G, GLN232E, GLN232G, GLN83E, GLN83G, GLN93E, GLN93G, GLN97E, GLN97G, GLU100E, GLU100G, GLU224E, GLU224G, GLU80E, GLU80G, HIS75E, LYS86E, LYS86G, LYS92E, LYS92G, SER221E, SER221G, THR213E, THR213G, TRP217E, TRP217G, TRP82E, TRP82G, TYR216E, TYR216G, TYR220E, TYR220G, VAL81E
• E-H: ALA266E, ALA266H, ALA268E, ALA268H, ARG117E, ARG117H, ARG203E, ARG203H, ARG237E, ARG237H, ARG239E, ARG239H, ARG242E, ARG242H, ARG246E, ARG246H, ARG252E, ARG252H, ARG279E, ARG279H, ARG96E, ARG96H, ASN212E, ASN212H, ASP118H, ASP225E, ASP225H, ASP228E, ASP228H, ASP277E, ASP277H, ASP47E, CYS223E, CYS223H, GLN232E, GLN232H, GLN234E, GLN234H, GLN264E, GLN264H, GLU100E, GLU100H, GLU106E, GLU106H, GLU112E, GLU112H, GLU207E, GLU207H, GLU211E, GLU211H, GLU224E, GLU224H, GLU230E, GLU230H, GLY115H, GLY249E, GLY249H, GLY283E, HIS240E, HIS240H, HIS45H, ILE209E, ILE209H, ILE248E, ILE248H, LEU108E, LEU108H, LEU226E, LEU226H, LEU235E, LEU235H, LEU267E, LEU267H, LEU269E, LEU269H, LEU275E, LEU275H, LYS251E, LYS251H, LYS92E, LYS92H, MET114E, MET114H, MET241E, MET241H, MET245E, MET245H, PHE116H, PHE233E, PHE233H, PHE238E, PHE238H, PHE250E, PHE250H, PHE271E, PHE271H, PHE272E, PHE272H, PHE276E, PHE276H, PRO110E, PRO110H, PRO273E, PRO273H, SER103E, SER103H, SER111E, SER111H, SER221E, SER221H, SER281E, SER281H, THR107E, THR107H, THR109E, THR109H, THR213E, THR213H, THR231E, THR231H, THR243E, THR243H, THR270E, THR270H, THR280E, THR280H, THR99E, THR99H, TRP102E, TRP102H, TRP236E, TRP236H, TYR113E, TYR113H, TYR210E, TYR210H, TYR220E, TYR220H, VAL227E, VAL227H, VAL229E, VAL229H, VAL244E, VAL244H, VAL247E, VAL247H, VAL260E, VAL260H, VAL278E, VAL278H, VAL282E, VAL282H, VAL284E
• F-G: ALA266F, ALA266G, ALA268F, ALA268G, ARG117F, ARG117G, ARG203F, ARG203G, ARG237F, ARG237G, ARG239F, ARG239G, ARG242F, ARG242G, ARG246F, ARG246G, ARG252F, ARG252G, ARG279F, ARG279G, ARG96F, ARG96G, ASN212F, ASN212G, ASP214F, ASP225F, ASP225G, ASP228F, ASP228G, ASP277F, ASP277G, ASP47G, CYS223F, CYS223G, GLN232F, GLN232G, GLN234F, GLN234G, GLN264F, GLN264G, GLU100F, GLU100G, GLU106F, GLU106G, GLU112F, GLU112G, GLU207F, GLU207G, GLU211F, GLU211G, GLU224F, GLU224G, GLU230F, GLU230G, GLY115F, GLY249F, GLY249G, GLY283G, HIS240F, HIS240G, ILE209F, ILE209G, ILE248F, ILE248G, LEU108F, LEU108G, LEU226F, LEU226G, LEU235F, LEU235G, LEU267F, LEU267G, LEU269F, LEU269G, LEU275F, LEU275G, LYS251F, LYS251G, LYS92F, LYS92G, MET114F, MET114G, MET241F, MET241G, MET245F, MET245G, PHE206G, PHE233F, PHE233G, PHE238F, PHE238G, PHE250F, PHE250G, PHE271F, PHE271G, PHE272F, PHE272G, PHE276F, PHE276G, PRO110F, PRO110G, PRO273F, PRO273G, SER103F, SER103G, SER111F, SER111G, SER221F, SER221G, SER281F, SER281G, THR107F, THR107G, THR109F, THR109G, THR213F, THR213G, THR231F, THR231G, THR243F, THR243G, THR270F, THR270G, THR280F, THR280G, THR99F, THR99G, TRP102F, TRP102G, TRP236F, TRP236G, TYR113F, TYR113G, TYR210F, TYR210G, TYR220F, TYR220G, VAL227F, VAL227G, VAL229F, VAL229G, VAL244F, VAL244G, VAL247F, VAL247G, VAL260F, VAL260G, VAL278F, VAL278G, VAL282F, VAL282G
• F-H: ALA89F, ALA89H, ARG215F, ARG215H, ARG218F, ARG218H, ARG85F, ARG85H, ARG90F, ARG90H, ARG96F, ARG96H, ASN212F, ASN212H, ASP214F, ASP214H, GLN232H, GLN83F, GLN83H, GLN93F, GLN93H, GLN97F, GLN97H, GLU100F, GLU100H, GLU224F, GLU224H, GLU80F, GLU80H, HIS75F, HIS75H, LYS86F, LYS86H, LYS92F, LYS92H, SER221F, SER221H, THR213F, THR213H, TRP217F, TRP217H, TRP82F, TRP82H, TYR210F, TYR216F, TYR216H, TYR220F, TYR220H, VAL81F, VAL81H
• G-H: ALA150G, ALA150H, ALA194H, ALA195G, ALA195H, ALA198G, ALA198H, ALA266G, ALA266H, ALA268G, ALA268H, ALA36G, ALA36H, ALA44G, ALA44H, ALA66G, ALA66H, ALA71G, ALA71H, ALA72G, ALA72H, ALA89G, ALA89H, ARG117G, ARG117H, ARG132G, ARG132H, ARG158G, ARG158H, ARG21G, ARG21H, ARG237G, ARG237H, ARG239G, ARG239H, ARG246G, ARG246H, ARG252G, ARG252H, ARG29G, ARG29H, ARG70G, ARG70H, ARG8G, ARG8H, ARG90G, ARG90H, ARG96G, ARG96H, ASN140G, ASN140H, ASN142G, ASN142H, ASP118G, ASP118H, ASP152G, ASP152H, ASP17G, ASP17H, ASP31G, ASP31H, ASP47G, ASP47H, ASP9G, ASP9H, GLN101G, GLN101H, GLN127G, GLN127H, GLN130G, GLN130H, GLN144G, GLN144H, GLN147G, GLN147H, GLN264G, GLN264H, GLN265G, GLN265H, GLN32G, GLN32H, GLN37G, GLN37H, GLN38G, GLN38H, GLN54G, GLN54H, GLN56G, GLN56H, GLN93G, GLN93H, GLN97G, GLN97H, GLU100G, GLU100H, GLU106G, GLU106H, GLU112G, GLU112H, GLU11G, GLU11H, GLU135G, GLU135H, GLU19G, GLU19H, GLU48G, GLU48H, GLU59G, GLU59H, GLU68G, GLU68H, GLY121G, GLY121H, GLY125G, GLY125H, GLY139G, GLY139H, GLY13G, GLY13H, GLY20G, GLY20H, GLY253G, GLY253H, GLY255G, GLY255H, GLY256G, GLY256H, GLY259G, GLY259H, GLY25G, GLY25H, GLY261G, GLY261H, GLY26G, GLY26H, HIS15G, HIS15H, HIS196G, HIS196H, HIS240G, HIS45G, HIS45H, HIS46G, HIS46H, HIS67G, HIS67H, HIS75G, HIS75H, ILE14G, ILE14H, ILE52G, ILE52H, ILE53G, ILE53H, LEU105G, LEU105H, LEU108G, LEU108H, LEU10G, LEU10H, LEU120G, LEU120H, LEU129G, LEU129H, LEU146G, LEU146H, LEU18G, LEU18H, LEU22G, LEU22H, LEU263G, LEU263H, LEU267G, LEU267H, LEU269G, LEU269H, LEU28G, LEU28H, LEU30G, LEU30H, LEU33G, LEU33H, LEU34G, LEU34H, LEU40G, LEU40H, LEU50G, LEU50H, LEU60G, LEU60H, LEU62G, LEU62H, LEU64G, LEU64H, LEU65G, LEU65H, LEU69G, LEU69H, LEU7G, LEU7H, LEU88G, LEU88H, LEU95G, LEU95H, LEU98G, LEU98H, LYS141G, LYS141H, LYS63G, LYS63H, LYS86G, LYS86H, LYS92G, LYS92H, MET145G, MET145H, MET49G, MET49H, PHE116G, PHE116H, PHE126G, PHE126H, PHE136G, PHE149G, PHE149H, PHE262G, PHE262H, PHE271G, PHE271H, PHE51G, PHE51H, PRO110G, PRO122G, PRO122H, PRO12G, PRO12H, PRO143G, PRO143H, PRO153G, PRO153H, PRO273G, PRO273H, PRO39G, PRO39H, SER103G, SER103H, SER111G, SER111H, SER123G, SER123H, SER124G, SER124H, SER128G, SER128H, SER257G, SER257H, SER258G, SER258H, SER35G, SER35H, SER41G, SER41H, SER55G, SER55H, SER58G, SER58H, SER91G, SER91H, THR107G, THR107H, THR109G, THR109H, THR16G, THR16H, THR23G, THR23H, THR254G, THR254H, THR270G, THR270H, THR57G, THR57H, THR99G, THR99H, TRP102G, TRP102H, TRP236G, TRP236H, TRP61G, TRP61H, TRP82G, TRP82H, TYR113G, TYR113H, TYR131G, TYR131H, TYR151G, TYR151H, TYR24G, TYR24H, TYR27G, TYR27H, VAL104G, VAL104H, VAL119G, VAL119H, VAL148G, VAL148H, VAL197G, VAL197H, VAL87G, VAL87H, VAL94G, VAL94H