3DXD

crystal structure of the intracellular domain of human app (t668e mutant) in complex with fe65-ptb2

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 85
  • Norm. En. per Res.: -4.3218
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-46.7041	2.4171	-328.395	-372.682	90	15	8	11885	1	13	11
A-C	-49.6525	2.3226	-201.861	-249.191	60	5	1	7264	0	12	15
A-D	0.0	0.0	-1.0243	-1.0243	7	0	0	98	0	1	0
B-C	0.0	0.0	-0.2875	-0.2875	6	0	0	74	0	1	0
C-D	-47.8452	7.9138	-327.424	-367.3553	85	18	9	11394	0	13	11

Interface residues

• A-B: ALA588A, ALA613A, ALA622A, ALA626A, ALA627A, ALA630A, ALA643A, ALA644A, ALA649A, ALA652A, ALA653A, ALA664A, ARG605A, ARG607A, ARG616A, ARG657A, ARG665A, ASN563A, ASN642A, ASN680B, ASN684B, ASP560A, ASP617A, ASP663A, CYS639A, CYS654A, CYS661A, GLN651A, GLN659A, GLN678B, GLN679B, GLN692B, GLU648A, GLU668B, GLU670B, GLU671B, GLU683B, GLU691B, GLY558A, GLY615A, GLY628A, GLY681B, HIS619A, HIS673B, ILE562A, ILE624A, LEU590A, LEU609A, LEU612A, LEU646A, LEU656A, LEU662A, LEU674B, LYS660A, LYS676B, LYS688B, MET625A, MET655A, MET677B, MET693B, PHE608A, PHE611A, PHE621A, PHE623A, PHE632A, PHE689B, PHE690B, PRO556A, PRO587A, PRO629A, PRO641A, PRO669B, PRO685B, SER610A, SER631A, SER645A, SER647A, SER666A, SER675B, THR620A, THR686B, TYR658A, TYR682B, TYR687B, VAL557A, VAL559A, VAL606A, VAL614A, VAL618A, VAL650A
• A-C: ALA565A, ALA565C, ARG575A, ARG575C, ARG616A, ARG616C, ASN563A, ASN563C, ASP560A, ASP560C, ASP617A, ASP617C, GLN577A, GLN577C, GLU567A, GLU567C, GLU576A, GLU576C, GLY564A, GLY564C, GLY615A, GLY615C, HIS619A, HIS619C, ILE562A, ILE562C, LEU548A, LEU548C, LEU566A, LEU566C, LEU570A, LEU570C, LYS555A, LYS555C, SER568A, SER568C, SER571A, SER571C, SER572A, SER572C, SER573A, SER573C, SER574A, SER574C, THR620A, THR620C, TRP578A, TRP578C, TRP638A, TRP638C, VAL559A, VAL559C, VAL561A, VAL561C, VAL569A, VAL569C, VAL614A, VAL614C, VAL618A, VAL618C
• A-D: ASP560A, GLN678D, GLN679D, GLU567A, GLY564A, LYS555A, VAL561A
• B-C: ASP560C, GLN678B, GLN679B, GLU567C, GLY564C, LYS555C
• C-D: ALA588C, ALA613C, ALA622C, ALA626C, ALA627C, ALA630C, ALA643C, ALA644C, ALA652C, ALA653C, ALA664C, ARG605C, ARG607C, ARG616C, ARG657C, ARG665C, ARG672D, ASN563C, ASN642C, ASN680D, ASN684D, ASP560C, ASP617C, CYS654C, CYS661C, GLN651C, GLN659C, GLN678D, GLN679D, GLN692D, GLU648C, GLU670D, GLU671D, GLU683D, GLU691D, GLY558C, GLY615C, GLY628C, GLY681D, HIS619C, HIS673D, ILE562C, ILE624C, LEU590C, LEU609C, LEU612C, LEU646C, LEU656C, LEU662C, LEU674D, LYS660C, LYS676D, LYS688D, MET625C, MET655C, MET677D, PHE608C, PHE611C, PHE621C, PHE623C, PHE632C, PHE689D, PHE690D, PRO556C, PRO587C, PRO629C, PRO641C, PRO669D, PRO685D, SER610C, SER631C, SER645C, SER647C, SER675D, THR620C, THR686D, TYR658C, TYR682D, TYR687D, VAL557C, VAL559C, VAL606C, VAL614C, VAL618C, VAL650C