3DXA

crystal structure of the dm1 tcr in complex with hla-b*4405 and decamer ebv antigen

• Total interactions analyzed: 105
• Total true interactions: 34
• Strongest Interaction:
  • Chains: C-E
  • Int. Res.: 25
  • Norm. En. per Res.: -6.797
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.8935	-89.9523	-343.489	-482.3348	124	23	2	12677	5	45	40
A-C	-52.5491	-42.6372	-256.935	-352.1213	93	30	5	9980	5	25	26
A-D	-11.0321	-45.8504	-81.4921	-138.3746	47	7	1	3569	3	15	13
A-E	-18.7603	-16.8462	-63.8736	-99.48	50	2	0	3064	2	25	19
A-I	0.0	0.0	-0.2093	-0.2093	6	0	0	65	0	2	2
A-J	0.0	12.8326	-61.8427	-49.0101	31	5	0	2680	0	7	13
A-K	0.0	23.2509	-43.014	-19.7631	53	0	0	2187	0	23	20
C-D	0.0	0.0	-38.8978	-38.8978	18	1	1	1548	0	2	3
C-E	-14.4255	-83.1743	-72.3246	-169.9244	25	6	1	2270	7	8	8
C-J	0.0	0.0	-0.0166	-0.0166	5	0	0	13	0	0	2
D-E	-29.1268	-0.9824	202.995	172.8859	201	27	12	21942	6	42	41
D-F	0.0	0.0	-0.2003	-0.2003	5	0	0	63	0	2	1
D-K	-12.8495	-4.9578	-64.9719	-82.7792	44	4	0	3345	1	16	18
D-N	0.0	0.0	-3.1916	-3.1916	20	0	0	342	0	8	7
E-F	0.0	12.4781	-45.6624	-33.1843	30	1	0	2170	0	7	11
E-H	0.0	0.0	-0.0216	-0.0216	5	0	0	17	0	0	2
E-J	-7.9567	-49.8106	-100.671	-158.4383	68	5	0	4574	11	32	26
E-N	0.0	0.0	-0.0309	-0.0309	3	0	0	16	0	0	0
F-G	-47.881	-126.9597	-358.841	-533.6818	124	21	3	13084	6	51	43
F-H	-44.7104	-38.6875	-266.525	-349.9229	90	34	5	9890	5	24	26
F-I	-7.0287	0.0	-86.3397	-93.3684	50	10	1	3637	3	15	12
F-J	-14.3189	-11.9851	-81.4174	-107.7214	51	5	0	3428	1	26	20
F-N	0.0	1.258	0.0	1.258	2	0	0	0	0	3	5
H-I	0.0	0.0	-43.5011	-43.5011	18	2	1	1669	0	2	3
H-J	-8.9771	-82.8513	-65.1699	-156.9983	25	7	0	2233	6	8	8
I-J	-28.0238	2.2557	207.361	181.593	204	38	12	21932	6	42	42
I-N	0.0	0.0	-0.2307	-0.2307	13	0	0	77	0	3	4
K-L	-33.468	-82.2218	-307.376	-423.0657	116	17	2	11584	4	44	37
K-M	-37.9684	-34.9349	-283.708	-356.6114	93	24	5	10273	5	25	29
K-N	-4.8388	0.0	-70.5205	-75.3593	46	2	1	3187	3	12	12
K-O	-26.1601	-10.2921	-80.0219	-116.4741	50	6	0	3478	2	26	21
M-N	0.0	0.0	-34.0696	-34.0696	18	0	1	1391	0	2	2
M-O	-9.1371	-80.1592	-61.5547	-150.851	25	6	0	2231	6	8	8
N-O	-33.2793	-0.773	86.9417	52.8894	199	34	12	22015	6	43	42

Interface residues

• A-B: ALA117A, ALA11A, ALA125A, ALA15B, ALA211A, ALA236A, ARG12B, ARG14A, ARG17A, ARG202A, ARG21A, ARG234A, ARG239A, ARG35A, ARG3B, ARG48A, ARG6A, ARG97A, ARG97B, ASN24B, ASP114A, ASP119A, ASP122A, ASP238A, ASP30A, ASP34B, ASP37A, ASP53B, ASP59B, ASP96B, ASP98B, CYS25B, GLN115A, GLN242A, GLN2B, GLN87A, GLN8B, GLN96A, GLU229A, GLU232A, GLU46A, GLY120A, GLY207A, GLY237A, GLY26A, GLY29B, HIS13B, HIS188A, HIS191A, HIS192A, HIS31B, HIS51B, HIS84B, HIS93A, ILE124A, ILE1B, ILE23A, ILE35B, ILE7B, ILE94A, ILE95A, LEU206A, LEU23B, LEU32A, LEU54B, LEU64B, LEU65B, LYS121A, LYS186A, LYS243A, LYS58B, LYS6B, MET12A, MET98A, MET99B, PHE22B, PHE241A, PHE30B, PHE36A, PHE56B, PHE62B, PHE8A, PRO14B, PRO193A, PRO235A, PRO32B, SER11B, SER13A, SER28B, SER33B, SER52B, SER55B, SER57B, SER61B, SER92A, THR10A, THR190A, THR200A, THR233A, THR240A, THR24A, TRP204A, TRP244A, TRP60B, TRP95B, TYR10B, TYR113A, TYR116A, TYR118A, TYR123A, TYR26B, TYR27A, TYR63B, TYR66B, TYR67B, TYR7A, TYR85A, TYR99A, TYR9A, VAL231A, VAL25A, VAL27B, VAL34A, VAL9B
• A-C: ALA117A, ALA139A, ALA140A, ALA149A, ALA150A, ALA153A, ALA158A, ALA81A, ARG151A, ARG157A, ARG170A, ARG62A, ARG6A, ARG79A, ARG83A, ARG97A, ARG9C, ASN3C, ASN70A, ASN77A, ASP114A, ASP156A, ASP6C, CYS164A, GLN144A, GLN155A, GLN65A, GLN72A, GLN96A, GLU154A, GLU166A, GLU1C, GLU2C, GLU55A, GLU58A, GLU63A, GLU76A, GLY100A, GLY26A, ILE124A, ILE142A, ILE52A, ILE66A, ILE94A, ILE95A, LEU160A, LEU163A, LEU168A, LEU4C, LEU5C, LEU78A, LEU82A, LYS146A, LYS45A, LYS68A, MET5A, PHE10C, PHE22A, PHE33A, PHE36A, PHE7C, PHE8A, SER167A, SER67A, THR143A, THR24A, THR64A, THR69A, THR71A, THR73A, THR80A, TRP133A, TRP147A, TRP51A, TRP60A, TYR116A, TYR118A, TYR123A, TYR159A, TYR171A, TYR59A, TYR74A, TYR7A, TYR84A, TYR85A, TYR99A, TYR9A, VAL152A, VAL165A, VAL25A, VAL28A, VAL34A, VAL8C
• A-D: ALA150A, ALA153A, ALA158A, ARG151A, ARG157A, ARG62A, ARG84D, ASN31D, ASN59D, ASN66D, ASN70A, ASP156A, ASP61A, CYS164A, GLN111D, GLN155A, GLN65A, GLU154A, GLU161A, GLU166A, GLU32D, GLU58A, GLU63A, GLU67D, GLY108D, GLY109D, GLY162A, GLY30D, GLY56D, HIS55D, ILE66A, LEU160A, LEU163A, LEU57D, LYS112D, LYS3D, LYS58D, SER29D, THR64A, THR68D, THR69A, TRP107D, TYR110D, TYR159A, TYR33D, TYR59A, VAL152A
• A-E: ALA149A, ALA150A, ALA60E, ARG107E, ARG109E, ARG151A, ARG31E, ARG70E, ARG75A, ARG79A, ARG83A, ASN30E, ASN58E, ASN70A, ASN77A, ASP110E, ASP111E, ASP61A, GLN57E, GLN61E, GLN65A, GLN72A, GLU19A, GLU58A, GLU59E, GLU67E, GLU76A, GLY84E, ILE66A, LEU66E, LYS146A, LYS68A, LYS68E, PHE52E, PHE56E, SER112E, SER67A, THR64A, THR69A, THR71A, THR73A, THR80A, TRP147A, TYR108E, TYR113E, TYR40E, TYR55E, TYR74A, TYR84A, VAL152A
• A-I: ARG137I, ASN86A, GLN87A, GLU89A, LYS140I, SER88A
• A-J: ALA139A, ALA149A, ALA150A, ALA252J, ALA256J, ARG145A, ARG218J, ARG255J, ARG83A, ASN216J, ASN219J, ASN86A, ASP257J, GLN141A, GLN144A, GLN215J, GLU142J, GLU148A, GLU251J, GLY254J, HIS220J, ILE142A, LYS146A, PRO217J, THR138A, THR143A, THR212J, THR80A, TRP147A, TRP253J, TYR84A
• A-K: ALA149A, ALA150A, ALA153A, ARG108A, ARG108K, ARG111A, ARG145A, ARG151A, ARG157A, ARG219K, ASN127A, ASP106A, ASP106K, ASP129A, ASP220K, ASP223K, GLN218K, GLN262K, GLU128A, GLU148A, GLU154A, GLU222K, GLU264K, GLY104A, GLY104K, GLY107A, GLY107K, GLY112A, GLY1A, GLY1K, GLY221K, HIS260K, HIS263K, LEU109A, LEU109K, LEU110A, LEU110K, LEU130A, LEU266K, LEU270K, LYS268K, PRO105A, PRO105K, PRO267K, PRO269K, SER131A, SER132A, SER2A, THR134A, THR214K, THR225K, THR258K, VAL103A
• C-D: ASN31D, ASN3C, ASP6C, GLN111D, GLU1C, GLU2C, GLY108D, GLY109D, HIS55D, LEU4C, LEU57D, LEU5C, PHE7C, TRP107D, TYR110D, TYR33D, TYR40D, VAL8C
• C-E: ARG107E, ARG109E, ARG31E, ARG9C, ASN114E, ASN30E, ASN58E, ASP110E, ASP111E, ASP6C, GLN57E, GLU115E, GLU28E, HIS29E, LEU4C, LEU5C, LEU66E, PHE10C, PHE7C, SER112E, TYR108E, TYR113E, TYR40E, TYR55E, VAL8C
• C-J: ARG218J, ARG9C, PHE10C, PHE7C, TRP253J
• D-E: ALA105E, ALA132D, ALA139E, ALA146E, ALA154E, ALA160E, ALA186D, ALA188D, ALA195E, ALA202E, ALA211E, ALA250E, ALA252E, ARG107E, ARG123E, ARG137D, ARG177D, ARG200E, ARG206E, ARG208E, ARG255E, ARG31E, ARG43E, ARG70E, ASN114E, ASN128D, ASN184D, ASN69D, ASP130D, ASP138D, ASP143D, ASP151D, ASP165D, ASP170D, ASP175D, ASP180D, ASP186E, CYS104E, CYS147D, CYS158E, CYS172D, CYS184E, CYS197D, GLN111D, GLN116E, GLN122D, GLN127D, GLN135D, GLN152E, GLN160D, GLN188E, GLN193E, GLN44D, GLN44E, GLN48D, GLN48E, GLN51D, GLN57E, GLU115E, GLU137E, GLU142E, GLU145E, GLU147E, GLU169E, GLU192E, GLU216D, GLU251E, GLU51E, GLU67E, GLU70D, GLY108D, GLY109D, GLY116D, GLY118D, GLY119E, GLY121E, GLY162E, GLY182E, GLY47E, GLY49D, GLY49E, GLY56D, HIS150E, HIS180E, HIS46D, HIS55D, ILE105D, ILE148E, ILE168D, ILE53D, ILE54D, LEU103E, LEU136D, LEU148D, LEU156E, LEU159E, LEU174D, LEU190E, LEU203E, LEU207E, LEU46E, LEU53E, LEU66E, LEU71E, LYS112D, LYS120D, LYS140D, LYS144D, LYS153E, LYS171D, LYS182D, LYS191E, LYS68E, MET101E, MET176D, MET179D, MET78D, PHE115D, PHE117E, PHE118E, PHE141E, PHE149D, PHE152D, PHE181D, PHE211D, PHE212D, PHE52E, PRO120E, PRO129D, PRO131D, PRO143E, PRO187E, PRO189E, PRO194E, PRO213D, PRO215D, PRO50D, PRO50E, SER112E, SER139D, SER141D, SER142D, SER144E, SER145D, SER149E, SER161D, SER164D, SER178D, SER181E, SER183D, SER185D, SER190D, SER199E, SER204E, SER205E, SER210E, SER214D, SER47D, SER69E, THR114D, THR117D, THR150D, THR151E, THR155E, THR161E, THR169D, THR185E, THR2E, THR45E, THR54E, TRP107D, TRP189D, TRP214E, TRP253E, TYR103D, TYR110D, TYR113E, TYR134D, TYR167D, TYR201E, TYR33D, TYR40D, TYR40E, TYR42D, TYR42E, TYR52D, TYR55E, VAL101D, VAL106D, VAL113D, VAL133D, VAL138E, VAL140E, VAL146D, VAL157E, VAL158D, VAL166D, VAL173D, VAL183E, VAL187D, VAL209E
• D-F: ASN86F, GLN87F, GLU89F, LYS140D, SER88F
• D-K: ALA149K, ALA153K, ALA18D, ALA19D, ALA79D, ARG108K, ARG111K, ARG151K, ARG157K, ARG17D, ASN127K, ASN20D, ASN59D, ASN66D, ASN69D, ASP129K, GLN144K, GLU128K, GLU148K, GLU154K, GLU161K, GLU67D, GLU70D, GLU84D, GLY112K, HIS93D, ILE54D, ILE82D, ILE90D, LEU109K, LEU110K, LEU130K, LEU81D, LEU89D, LEU91D, MET78D, PRO92D, SER131K, SER132K, SER80D, THR68D, THR88D, TRP133K, VAL152K
• D-N: ARG177D, ARG97D, ASN59N, ASN66N, ASN69N, ASP175D, ASP180D, HIS93D, HIS93N, ILE82N, ILE90N, LEU57N, LYS182D, MET179D, PHE181D, PRO92N, SER178D, SER80N, THR68N, THR95D
• E-F: ALA139F, ALA149F, ALA150F, ALA252E, ALA256E, ARG145F, ARG218E, ARG255E, ARG79F, ARG83F, ASN216E, ASN219E, ASN86F, ASP257E, GLN144F, GLN215E, GLU148F, GLU251E, GLU76F, GLY254E, HIS220E, ILE142F, LYS146F, PRO217E, THR138F, THR143F, THR80F, TRP147F, TRP253E, TYR84F
• E-H: ARG218E, ARG9H, PHE10H, PHE7H, TRP253E
• E-J: ALA250E, ALA250J, ALA252E, ALA252J, ARG109E, ARG109J, ARG218E, ARG218J, ARG222E, ARG222J, ARG22E, ARG22J, ASN175E, ASN175J, ASN219E, ASN219J, ASP110E, ASP110J, ASP111E, ASP111J, ASP24E, ASP24J, GLN224E, GLN224J, GLU115E, GLU115J, GLU178E, GLU178J, GLU232E, GLU232J, GLU251E, GLU251J, GLU28E, GLU28J, GLY176E, GLY176J, GLY3E, GLY3J, HIS220E, HIS220J, HIS29E, HIS29J, ILE247E, ILE247J, ILE26E, ILE26J, LYS177E, LYS177J, PHE117E, PHE117J, PHE221E, PHE221J, PRO25E, PRO25J, SER112E, SER112J, SER249E, SER249J, SER27E, SER27J, TRP173E, TRP173J, TRP253E, TRP253J, TYR108E, TYR108J, VAL174E, VAL174J
• E-N: HIS93N, SER210E, THR212E
• F-G: ALA117F, ALA11F, ALA125F, ALA15G, ALA205F, ALA236F, ARG12G, ARG14F, ARG17F, ARG202F, ARG21F, ARG234F, ARG239F, ARG35F, ARG3G, ARG48F, ARG6F, ARG97F, ARG97G, ASN24G, ASP114F, ASP119F, ASP122F, ASP238F, ASP30F, ASP34G, ASP37F, ASP53G, ASP59G, ASP96G, ASP98G, CYS25G, GLN115F, GLN242F, GLN2G, GLN87F, GLN8G, GLN96F, GLU229F, GLU232F, GLU46F, GLU50G, GLY120F, GLY207F, GLY237F, GLY26F, GLY29G, HIS13G, HIS188F, HIS191F, HIS192F, HIS31G, HIS51G, HIS84G, HIS93F, ILE124F, ILE1G, ILE23F, ILE35G, ILE7G, ILE94F, ILE95F, LEU206F, LEU23G, LEU32F, LEU54G, LEU64G, LEU65G, LYS121F, LYS186F, LYS243F, LYS58G, LYS6G, MET12F, MET98F, MET99G, PHE22G, PHE241F, PHE30G, PHE36F, PHE56G, PHE62G, PHE8F, PRO14G, PRO193F, PRO235F, PRO32G, SER11G, SER13F, SER28G, SER33G, SER52G, SER55G, SER57G, SER61G, SER92F, THR10F, THR190F, THR200F, THR233F, THR240F, THR24F, TRP204F, TRP244F, TRP60G, TRP95G, TYR10G, TYR113F, TYR116F, TYR118F, TYR123F, TYR26G, TYR27F, TYR63G, TYR66G, TYR67G, TYR7F, TYR99F, TYR9F, VAL231F, VAL25F, VAL27G, VAL34F, VAL9G
• F-H: ALA117F, ALA139F, ALA140F, ALA149F, ALA150F, ALA153F, ALA158F, ALA81F, ARG151F, ARG157F, ARG170F, ARG62F, ARG6F, ARG79F, ARG83F, ARG97F, ARG9H, ASN3H, ASN70F, ASN77F, ASP114F, ASP156F, ASP6H, CYS164F, GLN144F, GLN155F, GLN65F, GLN72F, GLN96F, GLU154F, GLU166F, GLU1H, GLU2H, GLU55F, GLU63F, GLU76F, GLY100F, GLY26F, ILE124F, ILE142F, ILE52F, ILE66F, ILE95F, LEU160F, LEU163F, LEU168F, LEU4H, LEU5H, LEU78F, LEU82F, LYS146F, LYS45F, LYS68F, MET5F, PHE10H, PHE22F, PHE33F, PHE36F, PHE7H, PHE8F, SER167F, SER67F, THR143F, THR24F, THR64F, THR69F, THR71F, THR73F, THR80F, TRP133F, TRP147F, TRP51F, TYR116F, TYR118F, TYR123F, TYR159F, TYR171F, TYR59F, TYR74F, TYR7F, TYR84F, TYR85F, TYR99F, TYR9F, VAL152F, VAL165F, VAL25F, VAL28F, VAL34F, VAL8H
• F-I: ALA150F, ALA153F, ALA158F, ARG151F, ARG157F, ARG62F, ARG84I, ASN31I, ASN59I, ASN66I, ASN70F, ASP156F, ASP61F, CYS164F, GLN111I, GLN155F, GLN65F, GLU154F, GLU161F, GLU166F, GLU32I, GLU58F, GLU63F, GLU67I, GLU84I, GLY108I, GLY109I, GLY162F, GLY30I, GLY56I, HIS55I, ILE66F, ILE83I, LEU160F, LEU163F, LEU57I, LYS112I, LYS3I, LYS58I, SER29I, THR64F, THR68I, THR69F, THR73F, TRP107I, TYR110I, TYR159F, TYR33I, TYR59F, VAL152F
• F-J: ALA149F, ALA150F, ALA60J, ARG107J, ARG109J, ARG151F, ARG31J, ARG62F, ARG70J, ARG75F, ARG79F, ARG80J, ARG83F, ASN30J, ASN58J, ASN70F, ASN77F, ASP110J, ASP111J, ASP61F, GLN57J, GLN61J, GLN65F, GLN72F, GLU19F, GLU58F, GLU59J, GLU67J, GLU76F, GLY84J, ILE66F, LEU66J, LYS146F, LYS68F, LYS68J, PHE52J, PHE56J, SER112J, SER67F, THR64F, THR69F, THR71F, THR73F, THR80F, TRP147F, TYR108J, TYR113J, TYR40J, TYR55J, TYR74F, VAL152F
• F-N: ASP129F, ASP209N
• H-I: ASN31I, ASN3H, ASP6H, GLN111I, GLU1H, GLU2H, GLY108I, GLY109I, HIS55I, LEU4H, LEU57I, LEU5H, PHE7H, TRP107I, TYR110I, TYR33I, TYR40I, VAL8H
• H-J: ARG107J, ARG109J, ARG31J, ARG9H, ASN114J, ASN30J, ASN58J, ASP110J, ASP111J, ASP6H, GLN57J, GLU115J, GLU28J, HIS29J, LEU4H, LEU5H, LEU66J, PHE10H, PHE7H, SER112J, TYR108J, TYR113J, TYR40J, TYR55J, VAL8H
• I-J: ALA105J, ALA132I, ALA139J, ALA146J, ALA154J, ALA160J, ALA186I, ALA188I, ALA195J, ALA202J, ALA211J, ALA250J, ALA252J, ARG107J, ARG123J, ARG137I, ARG177I, ARG200J, ARG206J, ARG208J, ARG255J, ARG31J, ARG43J, ARG70J, ASN114J, ASN128I, ASN184I, ASN69I, ASP111J, ASP130I, ASP138I, ASP143I, ASP151I, ASP165I, ASP170I, ASP175I, ASP180I, ASP186J, CYS104J, CYS147I, CYS158J, CYS172I, CYS184J, GLN111I, GLN116J, GLN122I, GLN127I, GLN135I, GLN152J, GLN160I, GLN188J, GLN193J, GLN44I, GLN44J, GLN48I, GLN48J, GLN51I, GLN57J, GLU115J, GLU137J, GLU142J, GLU145J, GLU147J, GLU169J, GLU192J, GLU216I, GLU251J, GLU51J, GLU67J, GLY108I, GLY109I, GLY116I, GLY118I, GLY119J, GLY121J, GLY162J, GLY182J, GLY47J, GLY49I, GLY49J, GLY56I, HIS150J, HIS167J, HIS180J, HIS46I, HIS55I, ILE105I, ILE148J, ILE168I, ILE53I, ILE54I, LEU103J, LEU136I, LEU148I, LEU156J, LEU159J, LEU174I, LEU190J, LEU203J, LEU207J, LEU46J, LEU53J, LEU66J, LEU71J, LEU96I, LYS112I, LYS120I, LYS140I, LYS144I, LYS153J, LYS162I, LYS171I, LYS182I, LYS191J, LYS68J, MET101J, MET176I, MET179I, MET78I, PHE115I, PHE117J, PHE118J, PHE141J, PHE149I, PHE152I, PHE163J, PHE181I, PHE211I, PHE212I, PHE52J, PRO120J, PRO129I, PRO131I, PRO143J, PRO187J, PRO189J, PRO194J, PRO213I, PRO215I, PRO50I, PRO50J, SER106J, SER112J, SER139I, SER141I, SER142I, SER144J, SER145I, SER149J, SER161I, SER164I, SER178I, SER181J, SER183I, SER185I, SER190I, SER199J, SER204J, SER205J, SER210J, SER214I, SER47I, SER69J, THR114I, THR117I, THR150I, THR151J, THR155J, THR161J, THR169I, THR185J, THR2J, THR54J, THR99I, TRP107I, TRP189I, TRP214J, TRP253J, TYR103I, TYR110I, TYR113J, TYR134I, TYR167I, TYR201J, TYR33I, TYR40I, TYR40J, TYR42I, TYR42J, TYR52I, TYR55J, VAL101I, VAL113I, VAL133I, VAL138J, VAL140J, VAL146I, VAL157J, VAL158I, VAL166I, VAL173I, VAL183J, VAL187I, VAL209J
• I-N: ARG177I, ARG17N, ASN157N, ASN59I, ASN66I, ASP84N, GLN155N, GLU67I, GLU70I, HIS93I, LYS85N, PRO8N, SER178I
• K-L: ALA117K, ALA11K, ALA125K, ALA211K, ALA236K, ARG111K, ARG12L, ARG14K, ARG17K, ARG202K, ARG21K, ARG234K, ARG239K, ARG35K, ARG3L, ARG48K, ARG6K, ARG97K, ARG97L, ASN24L, ASP114K, ASP119K, ASP122K, ASP238K, ASP30K, ASP34L, ASP37K, ASP53L, ASP59L, ASP96L, ASP98L, CYS25L, GLN115K, GLN242K, GLN2L, GLN87K, GLN8L, GLN96K, GLU232K, GLY120K, GLY207K, GLY237K, GLY26K, GLY29L, HIS13L, HIS188K, HIS191K, HIS192K, HIS31L, HIS51L, HIS93K, ILE124K, ILE1L, ILE23K, ILE7L, ILE94K, ILE95K, LEU206K, LEU23L, LEU32K, LEU54L, LEU64L, LEU65L, LYS121K, LYS186K, LYS243K, LYS58L, LYS6L, MET12K, MET98K, MET99L, PHE22L, PHE241K, PHE30L, PHE56L, PHE62L, PHE8K, PRO14L, PRO193K, PRO235K, PRO32L, SER11L, SER28L, SER33L, SER52L, SER55L, SER57L, SER61L, SER92K, THR10K, THR190K, THR233K, THR240K, THR24K, TRP204K, TRP244K, TRP60L, TRP95L, TYR10L, TYR113K, TYR116K, TYR118K, TYR123K, TYR26L, TYR27K, TYR63L, TYR66L, TYR67L, TYR7K, TYR85K, TYR99K, TYR9K, VAL231K, VAL25K, VAL27L, VAL9L
• K-M: ALA117K, ALA139K, ALA140K, ALA149K, ALA150K, ALA153K, ALA158K, ALA81K, ARG151K, ARG157K, ARG170K, ARG62K, ARG6K, ARG79K, ARG83K, ARG97K, ARG9M, ASN3M, ASN70K, ASN77K, ASP114K, ASP119K, ASP156K, ASP6M, CYS101K, CYS164K, GLN144K, GLN155K, GLN65K, GLN96K, GLU154K, GLU166K, GLU1M, GLU2M, GLU55K, GLU63K, GLU76K, GLY100K, GLY26K, ILE124K, ILE142K, ILE52K, ILE66K, ILE94K, ILE95K, LEU160K, LEU163K, LEU168K, LEU4M, LEU5M, LEU78K, LEU82K, LYS121K, LYS146K, LYS45K, LYS68K, MET5K, PHE10M, PHE22K, PHE33K, PHE36K, PHE7M, PHE8K, SER167K, SER67K, THR143K, THR24K, THR64K, THR69K, THR71K, THR73K, THR80K, TRP133K, TRP147K, TRP51K, TYR116K, TYR118K, TYR123K, TYR159K, TYR171K, TYR59K, TYR74K, TYR7K, TYR84K, TYR85K, TYR99K, TYR9K, VAL152K, VAL165K, VAL25K, VAL28K, VAL34K, VAL8M
• K-N: ALA150K, ALA153K, ALA158K, ARG151K, ARG157K, ARG62K, ARG84N, ASN31N, ASN59N, ASN66N, ASN70K, ASP156K, ASP61K, CYS164K, GLN111N, GLN155K, GLN65K, GLU154K, GLU161K, GLU166K, GLU32N, GLU58K, GLU63K, GLU67N, GLY108N, GLY109N, GLY162K, GLY30N, GLY56N, HIS55N, ILE66K, LEU160K, LEU163K, LEU57N, LYS112N, LYS3N, LYS58N, SER29N, THR68N, THR69K, TRP107N, TYR110N, TYR159K, TYR33N, TYR59K, VAL152K
• K-O: ALA149K, ALA150K, ALA60O, ARG109O, ARG151K, ARG31O, ARG70O, ARG75K, ARG79K, ARG80O, ARG83K, ASN30O, ASN58O, ASN70K, ASN77K, ASP110O, ASP111O, ASP61K, GLN57O, GLN61O, GLN65K, GLN72K, GLU19K, GLU58K, GLU59O, GLU67O, GLU76K, GLY84O, ILE66K, LEU66O, LYS146K, LYS68K, LYS68O, PHE52O, PHE56O, SER112O, SER67K, THR64K, THR69K, THR71K, THR73K, THR80K, TRP147K, TYR108O, TYR113O, TYR40O, TYR55O, TYR74K, TYR84K, VAL152K
• M-N: ASN31N, ASN3M, ASP6M, GLN111N, GLU1M, GLU2M, GLY108N, GLY109N, HIS55N, LEU4M, LEU57N, LEU5M, PHE7M, TRP107N, TYR110N, TYR33N, TYR40N, VAL8M
• M-O: ARG107O, ARG109O, ARG31O, ARG9M, ASN114O, ASN30O, ASN58O, ASP110O, ASP111O, ASP6M, GLN57O, GLU115O, GLU28O, HIS29O, LEU4M, LEU5M, LEU66O, PHE10M, PHE7M, SER112O, TYR108O, TYR113O, TYR40O, TYR55O, VAL8M
• N-O: ALA105O, ALA132N, ALA139O, ALA146O, ALA154O, ALA160O, ALA186N, ALA188N, ALA195O, ALA202O, ALA211O, ALA250O, ALA252O, ARG107O, ARG123O, ARG137N, ARG177N, ARG200O, ARG206O, ARG208O, ARG255O, ARG31O, ARG43O, ARG70O, ASN114O, ASN184N, ASN69N, ASP130N, ASP138N, ASP143N, ASP151N, ASP165N, ASP170N, ASP175N, ASP180N, ASP186O, CYS104O, CYS147N, CYS158O, CYS172N, CYS184O, CYS197N, GLN111N, GLN116O, GLN127N, GLN135N, GLN152O, GLN160N, GLN188O, GLN193O, GLN44N, GLN44O, GLN48N, GLN48O, GLN51N, GLN57O, GLN6O, GLU115O, GLU137O, GLU142O, GLU145O, GLU147O, GLU169O, GLU192O, GLU216N, GLU251O, GLU51O, GLU67O, GLU70N, GLY108N, GLY109N, GLY116N, GLY118N, GLY119O, GLY121O, GLY162O, GLY182O, GLY47O, GLY49N, GLY49O, GLY56N, HIS150O, HIS180O, HIS46N, HIS55N, ILE105N, ILE148O, ILE168N, ILE53N, ILE54N, LEU103O, LEU136N, LEU148N, LEU156O, LEU159O, LEU174N, LEU190O, LEU203O, LEU207O, LEU46O, LEU53O, LEU66O, LEU71O, LYS112N, LYS120N, LYS140N, LYS144N, LYS153O, LYS171N, LYS182N, LYS191O, LYS68O, MET101O, MET176N, MET179N, MET78N, PHE115N, PHE117O, PHE118O, PHE141O, PHE149N, PHE152N, PHE163O, PHE181N, PHE195N, PHE211N, PHE212N, PHE52O, PRO120O, PRO129N, PRO131N, PRO143O, PRO187O, PRO189O, PRO194O, PRO213N, PRO215N, PRO50N, PRO50O, SER112O, SER139N, SER141N, SER142N, SER144O, SER145N, SER149O, SER161N, SER164N, SER178N, SER181O, SER183N, SER185N, SER190N, SER199O, SER204O, SER205O, SER210O, SER214N, SER47N, SER69O, THR114N, THR117N, THR150N, THR151O, THR155O, THR161O, THR169N, THR185O, THR54O, TRP107N, TRP189N, TRP214O, TRP253O, TYR103N, TYR110N, TYR113O, TYR134N, TYR167N, TYR201O, TYR33N, TYR40N, TYR40O, TYR42N, TYR42O, TYR52N, TYR55O, VAL101N, VAL113N, VAL133N, VAL138O, VAL140O, VAL146N, VAL157O, VAL158N, VAL166N, VAL173N, VAL183O, VAL187N, VAL209O