3DV0

snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex

• Total interactions analyzed: 45
• Total true interactions: 18
• Strongest Interaction:
  • Chains: H-J
  • Int. Res.: 35
  • Norm. En. per Res.: -4.8362
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-69.6828	20.5696	-533.421	-582.5342	166	13	7	19831	4	30	28
A-C	-77.935	3.932	-485.912	-559.9151	187	17	25	19787	0	14	19
A-D	-47.1779	6.6887	-312.623	-353.1122	145	18	7	13453	1	25	31
A-F	0.0	16.5793	-1.7615	14.8178	8	5	0	360	0	3	2
B-C	-48.1118	-5.4526	-313.001	-366.5654	142	15	8	13217	1	27	33
B-D	-75.8805	-73.8557	-562.482	-712.2182	183	24	10	20661	13	30	34
B-I	0.0	-26.3188	-85.1467	-111.4655	39	1	2	3507	1	10	9
C-D	-71.1415	15.7056	-508.845	-564.2809	165	12	8	19653	4	32	29
C-F	0.0	28.1455	-14.7784	13.3671	34	2	0	943	1	22	21
D-I	-3.8607	0.0	-58.533	-62.3937	31	3	0	2361	0	5	4
E-F	-48.1647	12.5161	-497.728	-533.3766	163	18	9	19409	5	32	29
E-G	-88.2175	16.8442	-477.26	-548.6333	182	24	23	19690	0	14	19
E-H	-40.6135	6.0033	-315.911	-350.5213	141	16	7	13322	1	24	31
F-G	-58.454	-4.5991	-307.156	-370.2091	145	28	7	13223	2	27	35
F-H	-76.296	-59.4215	-563.43	-699.1475	179	27	9	20930	14	30	32
F-J	-3.8534	0.0	-56.48	-60.3334	34	7	0	2480	0	7	5
G-H	-47.7395	29.6862	-512.016	-530.0693	166	17	8	19625	4	28	28
H-J	-33.2012	-47.8585	-88.2061	-169.2658	35	4	2	3609	1	7	6

Interface residues

• A-B: ALA137B, ALA146A, ALA151A, ALA152A, ALA155A, ALA165A, ALA167A, ALA188A, ALA190A, ALA193A, ALA58B, ALA66B, ALA70B, ALA98B, ARG101B, ARG103B, ARG107B, ARG161A, ARG162B, ARG279B, ARG51B, ARG75B, ARG99B, ASN129A, ASN136A, ASN164B, ASN186A, ASN22B, ASN271B, ASN354A, ASP163B, ASP165B, ASP180A, ASP242B, ASP342A, ASP50B, ASP54B, ASP91B, ASP96A, GLN117A, GLN130A, GLN139B, GLN141A, GLN147A, GLN150A, GLN239B, GLN338A, GLN358A, GLN72B, GLN96B, GLU133A, GLU183A, GLU244B, GLU275B, GLU278B, GLU28B, GLU349A, GLU350A, GLU357A, GLU49B, GLU59B, GLU88B, GLU95A, GLY105B, GLY106B, GLY128A, GLY134A, GLY141B, GLY145A, GLY153A, GLY157A, GLY162A, GLY179A, GLY184A, GLY189A, GLY193B, GLY27B, GLY61B, GLY63B, GLY64B, GLY68B, GLY73B, GLY95B, HIS109B, HIS125A, HIS127A, ILE100B, ILE112B, ILE131A, ILE142A, ILE143A, ILE144A, ILE149A, ILE192B, ILE243B, ILE25B, ILE344A, ILE346A, ILE361A, ILE62B, ILE67B, ILE98A, LEU113A, LEU138A, LEU142B, LEU156A, LEU158A, LEU241B, LEU24B, LEU343A, LEU351A, LEU355A, LEU57B, LEU65B, LEU69B, LEU71B, LEU99A, LYS143B, LYS159A, LYS163A, LYS356A, MET110B, MET160A, MET347A, MET97B, PHE121A, PHE126A, PHE187A, PHE191A, PHE26B, PHE348A, PHE353A, PHE53B, PHE74B, PHE97A, PRO111B, PRO132A, PRO139A, PRO140A, PRO140B, PRO166B, PRO21B, PRO240B, PRO352A, PRO56B, PRO76B, SER345A, SER60B, SER92B, THR104B, THR237B, THR245B, THR55B, TYR102B, TYR108B, TYR148A, TYR182A, VAL135A, VAL137A, VAL154A, VAL166A, VAL167B, VAL23B, VAL340A, VAL52B, VAL89B
• A-C: ALA10A, ALA10C, ALA17A, ALA17C, ALA188A, ALA188C, ALA190A, ALA190C, ALA193A, ALA216A, ALA216C, ALA220A, ALA220C, ALA223A, ALA223C, ALA225A, ALA225C, ALA226A, ALA226C, ALA240A, ALA240C, ALA243A, ALA243C, ALA244A, ALA244C, ALA247A, ALA247C, ALA248A, ALA248C, ALA252A, ALA252C, ALA37A, ALA37C, ARG249A, ARG249C, ARG251A, ARG251C, ASN186A, ASN186C, ASN254A, ASN254C, ASN34A, ASN34C, ASP180A, ASP180C, GLN12A, GLN12C, GLN178A, GLN178C, GLN19A, GLN19C, GLN213A, GLN213C, GLN221A, GLN221C, GLN232A, GLN232C, GLN24A, GLN24C, GLN6A, GLN6C, GLU11A, GLU11C, GLU14A, GLU14C, GLU183A, GLU183C, GLU18A, GLU18C, GLU211A, GLU211C, GLU250A, GLU250C, GLU256A, GLU256C, GLU35A, GLU35C, GLU36A, GLU36C, GLU40A, GLU40C, GLY174A, GLY174C, GLY175A, GLY175C, GLY179A, GLY179C, GLY184A, GLY184C, GLY189A, GLY189C, GLY227A, GLY227C, GLY230A, GLY230C, GLY257A, GLY257C, ILE185A, ILE185C, ILE228A, ILE228C, ILE231A, ILE231C, ILE25A, ILE25C, ILE261A, ILE261C, LEU13A, LEU13C, LEU219A, LEU219C, LEU239A, LEU239C, LEU260A, LEU260C, LYS15A, LYS15C, LYS192A, LYS192C, LYS212A, LYS212C, LYS217A, LYS217C, LYS222A, LYS222C, LYS246A, LYS246C, MET38A, MET38C, PHE181A, PHE181C, PHE187A, PHE187C, PHE191A, PHE191C, PHE20A, PHE20C, PHE23A, PHE23C, PHE5A, PHE5C, PHE7A, PHE7C, PHE9A, PHE9C, PRO21A, PRO21C, PRO229A, PRO229C, PRO258A, PRO258C, PRO39A, PRO39C, PRO8A, PRO8C, SER177A, SER177C, THR176A, THR176C, THR214A, THR214C, THR218A, THR218C, THR22A, THR22C, THR259A, THR259C, THR4A, THR4C, TYR182A, TYR182C, TYR242A, TYR242C, VAL16A, VAL16C, VAL210A, VAL210C, VAL215A, VAL215C, VAL224A, VAL224C, VAL233A, VAL233C, VAL241A, VAL241C, VAL245A, VAL245C
• A-D: ALA146A, ALA205A, ALA292D, ALA293D, ALA301D, ALA303D, ALA332A, ALA58D, ARG123A, ARG264D, ARG290D, ARG71A, ASN129A, ASN310D, ASN33D, ASN354A, ASP173A, ASP180A, ASP295D, ASP29D, ASP313D, ASP333A, ASP342A, ASP54D, GLN130A, GLN141A, GLN178A, GLN213A, GLN263D, GLN265D, GLN302D, GLN338A, GLN358A, GLN44D, GLN81D, GLU126D, GLU211A, GLU28D, GLU304D, GLU316D, GLU357A, GLU366A, GLU49D, GLU59D, GLU88D, GLY124A, GLY128A, GLY145A, GLY172A, GLY174A, GLY175A, GLY179A, GLY27D, GLY31D, GLY34D, GLY35D, GLY61D, GLY70A, GLY73A, GLY84D, HIS123D, HIS125A, HIS127A, HIS128D, HIS271A, ILE142A, ILE143A, ILE144A, ILE149A, ILE206A, ILE344A, ILE346A, ILE361A, ILE62D, LEU120A, LEU127D, LEU308D, LEU343A, LEU351A, LEU355A, LEU57D, LEU72A, LYS212A, LYS222A, LYS312D, LYS320D, LYS337A, LYS339A, LYS365A, MET347A, PHE119A, PHE121A, PHE126A, PHE181A, PHE204A, PHE300D, PHE348A, PHE53D, PHE74A, PHE82D, PHE83D, PHE85D, PRO125D, PRO139A, PRO140A, PRO209A, PRO294D, PRO299D, PRO309D, PRO336A, PRO352A, PRO56D, SER122A, SER177A, SER207A, SER305D, SER345A, SER60D, THR124D, THR171A, THR176A, THR208A, THR214A, THR296D, THR317D, THR335A, THR341A, THR55D, TRP307D, TYR102A, TYR298D, TYR359A, TYR362A, TYR75A, TYR87D, VAL210A, VAL215A, VAL291D, VAL297D, VAL306D, VAL30D, VAL32D, VAL340A, VAL36D, VAL86D
• A-F: ARG180F, ARG251A, GLN2F, GLU256A, GLY255A, GLY257A, LYS192A, PHE179F
• B-C: ALA146C, ALA205C, ALA292B, ALA293B, ALA301B, ALA303B, ALA332C, ALA58B, ARG123C, ARG264B, ARG290B, ARG38B, ARG71C, ASN129C, ASN310B, ASN33B, ASN354C, ASP173C, ASP180C, ASP295B, ASP29B, ASP313B, ASP342C, ASP54B, GLN130C, GLN141C, GLN178C, GLN213C, GLN263B, GLN265B, GLN302B, GLN338C, GLN358C, GLN44B, GLN81B, GLU126B, GLU211C, GLU28B, GLU304B, GLU316B, GLU357C, GLU366C, GLU49B, GLU59B, GLU88B, GLY124C, GLY128C, GLY145C, GLY172C, GLY174C, GLY175C, GLY179C, GLY27B, GLY31B, GLY34B, GLY35B, GLY61B, GLY70C, GLY73C, GLY84B, HIS123B, HIS125C, HIS127C, HIS128B, HIS271C, ILE142C, ILE143C, ILE144C, ILE149C, ILE206C, ILE344C, ILE346C, ILE361C, ILE62B, LEU120C, LEU127B, LEU308B, LEU343C, LEU351C, LEU355C, LEU57B, LEU72C, LYS212C, LYS222C, LYS312B, LYS320B, LYS337C, LYS339C, LYS365C, MET347C, PHE121C, PHE126C, PHE181C, PHE204C, PHE300B, PHE348C, PHE53B, PHE74C, PHE82B, PHE83B, PHE85B, PRO125B, PRO139C, PRO140C, PRO209C, PRO294B, PRO299B, PRO309B, PRO352C, PRO56B, SER122C, SER177C, SER207C, SER305B, SER345C, SER60B, THR124B, THR171C, THR176C, THR208C, THR214C, THR272C, THR296B, THR335C, THR341C, THR55B, TRP307B, TYR102C, TYR298B, TYR359C, TYR362C, TYR75C, TYR87B, VAL210C, VAL297B, VAL306B, VAL30B, VAL32B, VAL340C, VAL36B, VAL52B, VAL86B
• B-D: ALA137B, ALA137D, ALA256B, ALA262B, ALA262D, ALA266B, ALA266D, ALA269B, ALA269D, ALA270B, ALA270D, ALA274B, ALA274D, ALA280B, ALA280D, ALA286B, ALA286D, ALA293B, ALA293D, ALA301B, ALA301D, ALA303B, ALA303D, ALA98B, ALA98D, ARG101B, ARG101D, ARG103B, ARG103D, ARG264B, ARG264D, ARG279B, ARG279D, ARG290B, ARG290D, ARG99B, ARG99D, ASN271B, ASN271D, ASN277B, ASN277D, ASP130B, ASP130D, ASP295B, ASP295D, ASP91B, ASP91D, CYS94B, CYS94D, GLN138B, GLN138D, GLN139B, GLN139D, GLN239B, GLN239D, GLN260B, GLN260D, GLN263B, GLN263D, GLN265B, GLN265D, GLN96B, GLN96D, GLU126B, GLU126D, GLU133B, GLU133D, GLU275B, GLU275D, GLU278B, GLU278D, GLU285B, GLU285D, GLU59B, GLU59D, GLU88B, GLU88D, GLY105B, GLY105D, GLY134B, GLY134D, GLY141B, GLY141D, GLY267B, GLY267D, GLY84B, GLY84D, GLY95B, GLY95D, HIS128B, HIS128D, ILE100B, ILE100D, ILE243B, ILE257B, ILE268B, ILE268D, ILE276B, ILE276D, ILE281B, ILE281D, ILE93B, ILE93D, LEU127B, LEU127D, LEU132B, LEU132D, LEU135B, LEU135D, LEU142B, LEU142D, LEU241B, LEU241D, LEU282B, LEU282D, LEU284B, LEU284D, LEU289B, LEU289D, LYS143B, LYS143D, LYS320B, MET90B, MET90D, MET97B, MET97D, PHE300B, PHE300D, PHE324B, PHE324D, PHE85B, PHE85D, PRO140B, PRO140D, PRO240B, PRO240D, PRO287B, PRO287D, PRO294B, PRO294D, PRO299B, PRO299D, SER129B, SER129D, SER131B, SER131D, SER283B, SER60B, SER60D, SER92B, SER92D, THR104B, THR104D, THR296B, THR296D, TRP307B, TRP307D, TYR102B, TYR102D, TYR298B, TYR298D, TYR87B, TYR87D, VAL136B, VAL136D, VAL144B, VAL144D, VAL238B, VAL238D, VAL258B, VAL272B, VAL272D, VAL273B, VAL273D, VAL288B, VAL288D, VAL297B, VAL297D, VAL321B, VAL86B, VAL86D, VAL89B, VAL89D
• B-I: ALA131I, ALA139I, ALA280B, ALA286B, ARG127I, ARG136I, ARG140I, ARG157I, ARG255B, ASN155I, ASN277B, ASN323B, GLU141I, GLU251B, GLU278B, GLU285B, GLY254B, ILE130I, ILE146I, ILE281B, LEU159I, LEU282B, LEU284B, LYS137I, LYS154I, LYS252B, MET132I, MET322B, PHE324B, PRO133I, PRO287B, SER134I, SER283B, THR253B, VAL129I, VAL135I, VAL158I, VAL288B, VAL321B
• C-D: ALA137D, ALA146C, ALA151C, ALA152C, ALA155C, ALA165C, ALA167C, ALA188C, ALA190C, ALA193C, ALA58D, ALA66D, ALA70D, ALA98D, ARG101D, ARG103D, ARG107D, ARG161C, ARG162D, ARG279D, ARG51D, ARG75D, ARG99D, ASN129C, ASN136C, ASN164D, ASN186C, ASN22D, ASN354C, ASP163D, ASP165D, ASP180C, ASP20D, ASP242D, ASP342C, ASP50D, ASP54D, ASP91D, ASP96C, GLN117C, GLN130C, GLN139D, GLN141C, GLN147C, GLN150C, GLN239D, GLN338C, GLN358C, GLN72D, GLN96D, GLU133C, GLU183C, GLU244D, GLU275D, GLU278D, GLU28D, GLU349C, GLU350C, GLU357C, GLU49D, GLU59D, GLU88D, GLU95C, GLY105D, GLY106D, GLY128C, GLY134C, GLY141D, GLY145C, GLY153C, GLY157C, GLY162C, GLY179C, GLY184C, GLY189C, GLY193D, GLY27D, GLY61D, GLY63D, GLY64D, GLY68D, GLY73D, GLY95D, HIS109D, HIS125C, HIS127C, ILE100D, ILE131C, ILE142C, ILE143C, ILE144C, ILE149C, ILE192D, ILE243D, ILE247D, ILE344C, ILE346C, ILE62D, ILE67D, ILE98C, LEU113C, LEU138C, LEU142D, LEU156C, LEU158C, LEU241D, LEU24D, LEU343C, LEU351C, LEU355C, LEU57D, LEU65D, LEU69D, LEU71D, LEU99C, LYS143D, LYS159C, LYS163C, LYS356C, MET110D, MET160C, MET347C, MET97D, PHE121C, PHE126C, PHE187C, PHE191C, PHE26D, PHE348C, PHE353C, PHE53D, PHE74D, PHE97C, PRO111D, PRO132C, PRO139C, PRO140C, PRO140D, PRO166D, PRO191D, PRO21D, PRO240D, PRO352C, PRO56D, PRO76D, SER345C, SER60D, SER92D, THR104D, THR237D, THR55D, TYR102D, TYR108D, TYR148C, TYR182C, VAL135C, VAL137C, VAL144D, VAL154C, VAL166C, VAL167D, VAL23D, VAL340C, VAL52D, VAL89D
• C-F: ALA10C, ALA1F, ALA216C, ARG180F, ARG203C, GLN181F, GLN232C, GLN2F, GLN7F, GLU14C, GLU182F, GLU185F, GLU187F, GLU211C, GLU289C, GLU28C, GLU41F, GLY186F, LEU13C, LEU264C, LYS217C, MET3F, PRO184F, PRO209C, PRO21C, THR189F, THR214C, THR218C, THR22C, TRP290C, TYR188F, VAL183F, VAL210C, VAL215C
• D-I: ALA131I, ALA280D, ALA286D, ARG136I, ARG157I, ARG255D, ASN155I, ASN277D, ASN323D, GLU141I, GLU285D, GLY254D, ILE130I, ILE281D, LEU159I, LEU282D, LEU284D, LYS137I, LYS154I, LYS160I, MET132I, MET322D, PHE324D, PRO133I, PRO287D, SER134I, SER283D, TYR138I, VAL135I, VAL288D, VAL321D
• E-F: ALA137F, ALA146E, ALA151E, ALA152E, ALA155E, ALA165E, ALA167E, ALA188E, ALA190E, ALA193E, ALA58F, ALA66F, ALA70F, ALA98F, ARG101F, ARG103F, ARG107F, ARG161E, ARG162F, ARG279F, ARG51F, ARG75F, ARG99F, ASN129E, ASN136E, ASN164F, ASN186E, ASN22F, ASN354E, ASP163F, ASP165F, ASP180E, ASP242F, ASP342E, ASP50F, ASP54F, ASP91F, ASP96E, GLN117E, GLN130E, GLN139F, GLN141E, GLN147E, GLN150E, GLN178E, GLN239F, GLN338E, GLN358E, GLN72F, GLN96F, GLU133E, GLU183E, GLU244F, GLU275F, GLU278F, GLU28F, GLU349E, GLU350E, GLU357E, GLU49F, GLU59F, GLU88F, GLU95E, GLY105F, GLY106F, GLY128E, GLY134E, GLY141F, GLY145E, GLY153E, GLY157E, GLY162E, GLY179E, GLY184E, GLY189E, GLY193F, GLY27F, GLY61F, GLY63F, GLY64F, GLY68F, GLY73F, GLY95F, HIS109F, HIS125E, HIS127E, ILE100F, ILE131E, ILE142E, ILE143E, ILE144E, ILE149E, ILE192F, ILE243F, ILE247F, ILE344E, ILE346E, ILE62F, ILE67F, ILE98E, LEU113E, LEU138E, LEU142F, LEU156E, LEU158E, LEU241F, LEU24F, LEU343E, LEU351E, LEU355E, LEU57F, LEU65F, LEU69F, LEU71F, LEU99E, LYS143F, LYS159E, LYS163E, LYS339E, LYS356E, MET110F, MET160E, MET347E, MET97F, PHE121E, PHE126E, PHE187E, PHE191E, PHE26F, PHE348E, PHE353E, PHE53F, PHE74F, PHE97E, PRO111F, PRO132E, PRO139E, PRO140E, PRO140F, PRO166F, PRO21F, PRO240F, PRO352E, PRO56F, PRO76F, SER345E, SER60F, SER92F, THR104F, THR237F, THR55F, TYR102F, TYR108F, TYR148E, TYR182E, VAL135E, VAL137E, VAL154E, VAL166E, VAL167F, VAL23F, VAL340E, VAL89F
• E-G: ALA10E, ALA10G, ALA17E, ALA17G, ALA188E, ALA188G, ALA190E, ALA190G, ALA193E, ALA216E, ALA216G, ALA220E, ALA220G, ALA223E, ALA223G, ALA225E, ALA225G, ALA226E, ALA226G, ALA240E, ALA240G, ALA243E, ALA243G, ALA244E, ALA244G, ALA247E, ALA247G, ALA248E, ALA248G, ALA37E, ALA37G, ARG251E, ARG251G, ASN186E, ASN186G, ASN254G, ASN34E, ASN34G, ASP180E, ASP180G, GLN12E, GLN12G, GLN178E, GLN178G, GLN19E, GLN19G, GLN213E, GLN213G, GLN221E, GLN221G, GLN232E, GLN232G, GLN24E, GLN24G, GLN6E, GLN6G, GLU11E, GLU11G, GLU14E, GLU14G, GLU183E, GLU183G, GLU18E, GLU18G, GLU211E, GLU211G, GLU250E, GLU250G, GLU256E, GLU256G, GLU35E, GLU35G, GLU36E, GLU36G, GLU40E, GLU40G, GLY174E, GLY174G, GLY175E, GLY175G, GLY179E, GLY179G, GLY184E, GLY184G, GLY189E, GLY189G, GLY227E, GLY227G, GLY230E, GLY230G, GLY257E, GLY257G, ILE149G, ILE185E, ILE185G, ILE228E, ILE228G, ILE231E, ILE231G, ILE25E, ILE25G, ILE261E, ILE261G, LEU13E, LEU13G, LEU219E, LEU219G, LEU239E, LEU239G, LEU260E, LEU260G, LYS15E, LYS15G, LYS192E, LYS192G, LYS212E, LYS212G, LYS217E, LYS217G, LYS222E, LYS222G, LYS246E, LYS246G, MET38E, MET38G, PHE181E, PHE181G, PHE187E, PHE187G, PHE191E, PHE191G, PHE20E, PHE20G, PHE23E, PHE23G, PHE5E, PHE5G, PHE7E, PHE7G, PHE9E, PHE9G, PRO21E, PRO21G, PRO229E, PRO229G, PRO258E, PRO258G, PRO39E, PRO39G, PRO8E, PRO8G, SER177E, SER177G, THR176E, THR176G, THR214E, THR214G, THR218E, THR218G, THR22E, THR22G, THR259E, THR259G, THR4E, THR4G, TYR182E, TYR182G, TYR242E, TYR242G, VAL16E, VAL16G, VAL210E, VAL215E, VAL215G, VAL224E, VAL224G, VAL233E, VAL233G, VAL241E, VAL241G, VAL245E, VAL245G
• E-H: ALA146E, ALA205E, ALA292H, ALA293H, ALA301H, ALA303H, ALA332E, ALA58H, ARG123E, ARG264H, ARG290H, ARG38H, ASN129E, ASN310H, ASN33H, ASN354E, ASP130H, ASP173E, ASP180E, ASP295H, ASP29H, ASP313H, ASP333E, ASP342E, ASP54H, GLN130E, GLN141E, GLN178E, GLN213E, GLN263H, GLN265H, GLN302H, GLN338E, GLN358E, GLN44H, GLN81H, GLU126H, GLU211E, GLU28H, GLU304H, GLU316H, GLU357E, GLU366E, GLU49H, GLU59H, GLU88H, GLY124E, GLY128E, GLY145E, GLY172E, GLY174E, GLY175E, GLY179E, GLY27H, GLY31H, GLY34H, GLY35H, GLY61H, GLY73E, GLY84H, HIS123H, HIS125E, HIS127E, HIS128H, ILE142E, ILE143E, ILE144E, ILE149E, ILE206E, ILE344E, ILE346E, ILE361E, LEU120E, LEU127H, LEU308H, LEU343E, LEU351E, LEU355E, LEU57H, LEU72E, LYS212E, LYS222E, LYS312H, LYS320H, LYS337E, LYS339E, LYS356E, LYS365E, MET347E, PHE119E, PHE121E, PHE126E, PHE181E, PHE204E, PHE300H, PHE348E, PHE53H, PHE74E, PHE82H, PHE85H, PRO125H, PRO139E, PRO140E, PRO209E, PRO294H, PRO299H, PRO309H, PRO336E, PRO352E, PRO56H, SER122E, SER177E, SER207E, SER305H, SER345E, SER60H, THR124H, THR171E, THR176E, THR208E, THR214E, THR296H, THR317H, THR335E, THR341E, THR55H, TRP307H, TYR102E, TYR298H, TYR359E, TYR362E, TYR75E, TYR87H, VAL210E, VAL297H, VAL306H, VAL30H, VAL32H, VAL340E, VAL36H, VAL86H
• F-G: ALA146G, ALA205G, ALA292F, ALA293F, ALA301F, ALA303F, ALA332G, ALA58F, ARG123G, ARG264F, ARG290F, ARG38F, ARG71G, ASN129G, ASN310F, ASN33F, ASN354G, ASP173G, ASP180G, ASP277G, ASP295F, ASP29F, ASP313F, ASP342G, ASP54F, GLN130G, GLN141G, GLN178G, GLN213G, GLN263F, GLN265F, GLN302F, GLN338G, GLN358G, GLN44F, GLN81F, GLU126F, GLU211G, GLU28F, GLU304F, GLU316F, GLU357G, GLU366G, GLU49F, GLU59F, GLU88F, GLY124G, GLY128G, GLY145G, GLY172G, GLY174G, GLY175G, GLY179G, GLY27F, GLY31F, GLY34F, GLY35F, GLY61F, GLY70G, GLY73G, GLY84F, HIS123F, HIS125G, HIS127G, HIS128F, HIS271G, ILE142G, ILE143G, ILE144G, ILE149G, ILE206G, ILE344G, ILE346G, ILE361G, ILE62F, LEU120G, LEU127F, LEU308F, LEU343G, LEU351G, LEU355G, LEU57F, LEU72G, LYS212G, LYS222G, LYS312F, LYS320F, LYS337G, LYS339G, LYS365G, MET347G, PHE119G, PHE121G, PHE126G, PHE181G, PHE204G, PHE300F, PHE348G, PHE53F, PHE74G, PHE82F, PHE85F, PRO125F, PRO139G, PRO140G, PRO209G, PRO294F, PRO299F, PRO309F, PRO352G, PRO56F, SER122G, SER177G, SER207G, SER305F, SER345G, SER60F, THR124F, THR171G, THR176G, THR208G, THR214G, THR272G, THR279G, THR296F, THR317F, THR341G, THR55F, TRP307F, TYR102G, TYR298F, TYR359G, TYR362G, TYR75G, TYR87F, VAL210G, VAL215G, VAL291F, VAL297F, VAL306F, VAL30F, VAL32F, VAL340G, VAL36F, VAL86F
• F-H: ALA137F, ALA137H, ALA256F, ALA262F, ALA262H, ALA266F, ALA266H, ALA269F, ALA269H, ALA270F, ALA270H, ALA274F, ALA274H, ALA280F, ALA280H, ALA286F, ALA286H, ALA293F, ALA293H, ALA301F, ALA301H, ALA303F, ALA303H, ALA98F, ALA98H, ARG101F, ARG101H, ARG103F, ARG103H, ARG264F, ARG264H, ARG279F, ARG279H, ARG290F, ARG290H, ARG99F, ARG99H, ASN271F, ASN271H, ASN277F, ASN277H, ASP130F, ASP130H, ASP295F, ASP295H, ASP91F, ASP91H, CYS94F, CYS94H, GLN138F, GLN138H, GLN139F, GLN139H, GLN239F, GLN239H, GLN260F, GLN263F, GLN263H, GLN265F, GLN265H, GLN96F, GLN96H, GLU126F, GLU126H, GLU133F, GLU133H, GLU275F, GLU275H, GLU278F, GLU278H, GLU285F, GLU285H, GLU59F, GLU59H, GLU88F, GLU88H, GLY105F, GLY105H, GLY106H, GLY134F, GLY134H, GLY141F, GLY141H, GLY267F, GLY267H, GLY84F, GLY84H, GLY95F, GLY95H, HIS128F, HIS128H, ILE100F, ILE100H, ILE243H, ILE268F, ILE268H, ILE276F, ILE276H, ILE281F, ILE281H, ILE93F, ILE93H, LEU127F, LEU127H, LEU132F, LEU132H, LEU135F, LEU135H, LEU142F, LEU142H, LEU241F, LEU282F, LEU282H, LEU284F, LEU284H, LEU289F, LEU289H, LYS143F, LYS143H, LYS320F, MET90F, MET90H, MET97H, PHE300F, PHE300H, PHE324F, PHE324H, PHE85F, PHE85H, PRO140F, PRO140H, PRO240F, PRO240H, PRO287F, PRO287H, PRO294F, PRO294H, PRO299F, PRO299H, SER129F, SER129H, SER131F, SER131H, SER283F, SER60F, SER60H, SER92F, SER92H, THR104F, THR104H, THR296F, THR296H, THR317H, TRP307F, TRP307H, TYR102F, TYR102H, TYR298F, TYR298H, TYR87F, TYR87H, VAL136F, VAL136H, VAL144F, VAL144H, VAL258F, VAL272F, VAL272H, VAL273F, VAL273H, VAL288F, VAL288H, VAL297F, VAL297H, VAL321F, VAL86F, VAL86H, VAL89F, VAL89H
• F-J: ALA131J, ALA139J, ALA280F, ALA286F, ARG136J, ARG140J, ARG157J, ARG255F, ASN277F, ASN323F, GLU141J, GLU161J, GLU285F, GLY153J, GLY254F, ILE130J, ILE281F, LEU159J, LEU282F, LEU284F, LYS137J, LYS154J, LYS160J, MET132J, MET322F, PHE324F, PRO133J, PRO287F, SER134J, SER283F, TYR138J, VAL135J, VAL288F, VAL321F
• G-H: ALA137H, ALA146G, ALA151G, ALA152G, ALA155G, ALA165G, ALA167G, ALA188G, ALA190G, ALA193G, ALA58H, ALA66H, ALA70H, ALA98H, ARG101H, ARG103H, ARG107H, ARG161G, ARG162H, ARG279H, ARG51H, ARG75H, ARG99H, ASN129G, ASN136G, ASN164H, ASN186G, ASN22H, ASN354G, ASP163H, ASP165H, ASP180G, ASP20H, ASP242H, ASP342G, ASP50H, ASP54H, ASP91H, ASP96G, GLN117G, GLN130G, GLN139H, GLN141G, GLN147G, GLN150G, GLN239H, GLN338G, GLN358G, GLN72H, GLN96H, GLU133G, GLU183G, GLU244H, GLU275H, GLU278H, GLU28H, GLU349G, GLU350G, GLU357G, GLU49H, GLU59H, GLU88H, GLU95G, GLY105H, GLY106H, GLY128G, GLY134G, GLY141H, GLY145G, GLY153G, GLY157G, GLY162G, GLY179G, GLY184G, GLY189G, GLY193H, GLY27H, GLY61H, GLY63H, GLY64H, GLY68H, GLY73H, GLY95H, HIS109H, HIS111G, HIS125G, HIS127G, ILE100H, ILE131G, ILE142G, ILE143G, ILE144G, ILE149G, ILE192H, ILE243H, ILE247H, ILE25H, ILE344G, ILE346G, ILE361G, ILE62H, ILE67H, ILE98G, LEU138G, LEU142H, LEU156G, LEU158G, LEU241H, LEU24H, LEU343G, LEU351G, LEU355G, LEU57H, LEU65H, LEU69H, LEU71H, LEU99G, LYS143H, LYS159G, LYS163G, LYS356G, MET110H, MET160G, MET347G, MET97H, PHE121G, PHE126G, PHE187G, PHE191G, PHE26H, PHE348G, PHE353G, PHE53H, PHE74H, PHE97G, PRO111H, PRO132G, PRO139G, PRO140G, PRO140H, PRO166H, PRO191H, PRO21H, PRO240H, PRO352G, PRO56H, PRO76H, SER345G, SER60H, SER92H, THR104H, THR237H, THR55H, TYR102H, TYR108H, TYR148G, TYR182G, VAL135G, VAL137G, VAL154G, VAL166G, VAL167H, VAL23H, VAL340G, VAL52H, VAL89H
• H-J: ALA131J, ALA139J, ALA280H, ALA286H, ARG136J, ARG140J, ARG157J, ARG255H, ASN155J, ASN277H, ASN323H, GLU141J, GLU251H, GLU285H, GLY156J, GLY254H, ILE130J, ILE146J, ILE281H, LEU282H, LEU284H, LYS137J, LYS154J, MET132J, MET322H, PHE324H, PRO133J, PRO287H, SER134J, SER283H, VAL129J, VAL135J, VAL158J, VAL288H, VAL321H