3DRX

x-ray crystal structure of human kctd5 protein crystallized in high- salt buffer

• Total interactions analyzed: 10
• Total true interactions: 10
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 157
  • Norm. En. per Res.: -3.2478
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-52.0668	-36.6992	-359.18	-447.946	160	15	17	15277	4	48	32
A-C	0.0	6.1559	-0.0299	6.126	5	0	0	14	0	2	2
A-D	0.0	5.5527	-0.0272	5.5256	6	0	0	14	0	2	3
A-E	-66.0755	-47.4871	-279.64	-393.2026	131	19	9	12148	5	46	29
B-C	-77.9062	-45.1972	-386.807	-509.9104	157	15	19	16238	3	48	31
B-D	0.0	5.0069	-0.0256	4.9813	5	0	0	15	0	2	3
B-E	0.0	5.4191	-0.0411	5.378	4	0	0	11	0	2	3
C-D	-60.6666	-40.0215	-388.316	-489.0041	174	22	15	16565	3	51	33
C-E	0.0	5.9652	-0.0611	5.9041	6	0	0	20	0	2	2
D-E	-71.452	-35.6739	-261.296	-368.4218	134	21	9	11531	4	46	27

Interface residues

• A-B: ALA118B, ALA199B, ALA34A, ALA36A, ALA89B, ARG107A, ARG145B, ARG159B, ARG38A, ARG47A, ARG47B, ARG59A, ARG59B, ARG72B, ARG94B, ASN104A, ASN114A, ASN114B, ASN49B, ASP116A, ASP116B, ASP177A, ASP81B, ASP83B, ASP85B, ASP93B, ASP95B, CYS203A, CYS203B, CYS74B, GLN162B, GLN170A, GLN183A, GLN183B, GLN37A, GLN60A, GLU119B, GLU120B, GLU124B, GLU125B, GLU127B, GLU165A, GLU167A, GLU182A, GLU182B, GLU200A, GLU208A, GLU208B, GLU86B, GLY100A, GLY109A, GLY121B, GLY178A, GLY40A, GLY51B, GLY52B, HIS108A, HIS156A, HIS156B, HIS210A, ILE113A, ILE187A, ILE187B, ILE92B, LEU103A, LEU106A, LEU111A, LEU117A, LEU117B, LEU123B, LEU161B, LEU168A, LEU184A, LEU184B, LEU202A, LEU202B, LEU209B, LEU35A, LEU48A, LEU48B, LEU56A, LEU62A, LEU62B, LEU70B, LEU73B, LEU80B, LEU91B, LYS110A, LYS115A, LYS115B, LYS141A, LYS148A, LYS155B, LYS180A, LYS207A, LYS207B, LYS44A, LYS84B, MET171A, MET175A, PHE128B, PHE181A, PHE181B, PHE201A, PHE55A, PHE69B, PHE99A, PRO101A, PRO153B, PRO39A, PRO96B, SER150B, SER173A, SER176A, SER186A, SER186B, SER206A, SER206B, SER41A, SER43A, SER68B, SER82B, THR149B, THR169A, THR174A, THR53A, THR53B, THR57A, THR58A, THR61A, THR87A, THR97A, THR97B, TRP179A, TRP45A, TYR129B, TYR158B, TYR54A, TYR54B, TYR71B, TYR90B, TYR98B, VAL112A, VAL122B, VAL152B, VAL154A, VAL154B, VAL157B, VAL160B, VAL172A, VAL185A, VAL185B, VAL204A, VAL204B, VAL205A, VAL205B, VAL42A, VAL46A, VAL46B, VAL50B
• A-C: ASP116A, ASP116C, GLN183A, GLN183C, LEU184A
• A-D: ASP116A, ASP116D, GLN183A, GLN183D, LEU184D, PHE181D
• A-E: ALA118A, ALA89A, ARG107E, ARG145A, ARG159A, ARG47E, ARG59E, ARG64E, ARG72A, ARG94A, ASN104E, ASN114A, ASN114E, ASN49A, ASP116A, ASP116E, ASP177E, ASP83A, ASP85A, ASP93A, ASP95A, CYS203A, CYS203E, GLN162A, GLN170E, GLN183A, GLN183E, GLN60E, GLU119A, GLU120A, GLU124A, GLU125A, GLU127A, GLU165E, GLU182A, GLU182E, GLU200E, GLU208A, GLU208E, GLY100E, GLY109E, GLY121A, GLY178E, GLY51A, GLY52A, HIS108E, HIS156A, HIS210E, ILE113A, ILE113E, ILE142A, ILE187A, ILE187E, ILE92A, LEU103E, LEU106E, LEU111E, LEU117A, LEU117E, LEU123A, LEU161A, LEU168E, LEU184A, LEU184E, LEU202A, LEU202E, LEU209A, LEU48E, LEU56E, LEU62E, LEU91A, LYS110E, LYS115A, LYS115E, LYS141E, LYS148E, LYS155A, LYS180E, LYS207A, LYS207E, LYS44E, LYS84A, MET171E, MET175E, PHE128A, PHE181E, PHE201E, PHE55E, PHE69A, PRO101E, PRO153A, PRO96A, SER150A, SER173E, SER176E, SER186A, SER186E, SER206A, SER206E, THR149A, THR169E, THR174E, THR53A, THR53E, THR57E, THR58E, THR61E, THR97A, TRP179A, TRP179E, TRP45E, TYR158A, TYR54A, TYR54E, TYR90A, TYR98A, VAL112E, VAL122A, VAL152A, VAL154A, VAL157A, VAL160A, VAL172E, VAL185A, VAL185E, VAL204A, VAL204E, VAL205A, VAL205E, VAL46E, VAL50A
• B-C: ALA118C, ALA34B, ALA36B, ALA89C, ARG107B, ARG145C, ARG159C, ARG38B, ARG47B, ARG47C, ARG59B, ARG59C, ARG72C, ARG94C, ASN104B, ASN114B, ASN114C, ASN49C, ASP116B, ASP116C, ASP177B, ASP81C, ASP83C, ASP85C, ASP93C, ASP95C, CYS203B, CYS203C, CYS74C, GLN162C, GLN170B, GLN183B, GLN183C, GLN37B, GLN60B, GLU119C, GLU120C, GLU124C, GLU125C, GLU127C, GLU165B, GLU167B, GLU182B, GLU182C, GLU200B, GLU208B, GLU208C, GLU86C, GLY100B, GLY109B, GLY121C, GLY178B, GLY40B, GLY51C, GLY52C, HIS108B, HIS156C, HIS210B, ILE113B, ILE142C, ILE187B, ILE187C, ILE92C, LEU103B, LEU106B, LEU111B, LEU117B, LEU117C, LEU123C, LEU161C, LEU168B, LEU184B, LEU184C, LEU202B, LEU202C, LEU209C, LEU35B, LEU48B, LEU48C, LEU56B, LEU62B, LEU62C, LEU70C, LEU73C, LEU80C, LEU91C, LYS110B, LYS115B, LYS115C, LYS139C, LYS141B, LYS148B, LYS155C, LYS180B, LYS207B, LYS44B, LYS84C, MET171B, MET175B, PHE128C, PHE181B, PHE181C, PHE201B, PHE55B, PHE69C, PRO101B, PRO153C, PRO39B, PRO96C, SER150C, SER173B, SER176B, SER186B, SER186C, SER206B, SER206C, SER41B, SER43B, SER68C, SER82C, THR149C, THR169B, THR174B, THR53B, THR53C, THR57B, THR58B, THR61B, THR87B, THR97C, TRP179B, TRP45B, TYR129C, TYR158C, TYR54B, TYR54C, TYR71C, TYR90C, TYR98C, VAL112B, VAL122C, VAL152C, VAL154B, VAL154C, VAL157C, VAL160C, VAL172B, VAL185B, VAL185C, VAL204B, VAL204C, VAL205B, VAL205C, VAL42B, VAL46B, VAL46C, VAL50C
• B-D: ASP116B, ASP116D, GLN183B, GLN183D, LEU184B
• B-E: ASP116B, ASP116E, GLN183B, GLN183E
• C-D: ALA118D, ALA199D, ALA36C, ALA89D, ARG107C, ARG145D, ARG159D, ARG38C, ARG47C, ARG59C, ARG64C, ARG72D, ARG94D, ASN104C, ASN114C, ASN114D, ASN192C, ASN192D, ASN195C, ASN195D, ASN211C, ASN49D, ASP116C, ASP116D, ASP177C, ASP79D, ASP81D, ASP83D, ASP85D, ASP93D, ASP95D, CYS203C, CYS203D, CYS74D, GLN162D, GLN170C, GLN183C, GLN183D, GLN198C, GLN198D, GLN37C, GLN60C, GLU119D, GLU120D, GLU124D, GLU125D, GLU127D, GLU165C, GLU166C, GLU182C, GLU182D, GLU200C, GLU208C, GLU208D, GLU86D, GLY100C, GLY109C, GLY121D, GLY178C, GLY188D, GLY194C, GLY40C, GLY51D, GLY52D, HIS108C, HIS156D, HIS210C, ILE113C, ILE113D, ILE187C, ILE187D, ILE92D, LEU103C, LEU106C, LEU111C, LEU117C, LEU117D, LEU123D, LEU161D, LEU168C, LEU184C, LEU184D, LEU202C, LEU202D, LEU209C, LEU209D, LEU35C, LEU48C, LEU48D, LEU56C, LEU62C, LEU62D, LEU70D, LEU73D, LEU80D, LEU91D, LYS110C, LYS115C, LYS115D, LYS141C, LYS148C, LYS155D, LYS180C, LYS207D, LYS44C, LYS84D, MET171C, MET175C, PHE128D, PHE181C, PHE181D, PHE201C, PHE55C, PHE69D, PRO101C, PRO153D, PRO39C, PRO96D, SER150D, SER173C, SER176C, SER186C, SER186D, SER189C, SER189D, SER190C, SER190D, SER206C, SER206D, SER41C, SER43C, SER82D, THR149D, THR169C, THR174C, THR53C, THR53D, THR57C, THR58C, THR61C, THR87C, THR97D, TRP179C, TRP179D, TRP45C, TYR129D, TYR158D, TYR191C, TYR191D, TYR193C, TYR193D, TYR54C, TYR54D, TYR71D, TYR90D, TYR98D, VAL112C, VAL122D, VAL152D, VAL154C, VAL154D, VAL157D, VAL160D, VAL172C, VAL185C, VAL185D, VAL204C, VAL204D, VAL205C, VAL205D, VAL42C, VAL46C, VAL46D, VAL50D
• C-E: ASP116C, ASP116E, GLN183C, GLN183E, LEU184C, LYS115C
• D-E: ALA118E, ALA199E, ALA34E, ALA89E, ARG107D, ARG145E, ARG159E, ARG38D, ARG47D, ARG59D, ARG72E, ARG94E, ASN104D, ASN114D, ASN114E, ASN49E, ASP116D, ASP116E, ASP177D, ASP79E, ASP83E, ASP85E, ASP93E, ASP95E, CYS203D, CYS203E, GLN162E, GLN170D, GLN183D, GLN183E, GLN37D, GLN60D, GLU119E, GLU120E, GLU124E, GLU125E, GLU165D, GLU182D, GLU182E, GLU200D, GLU208D, GLU208E, GLU86E, GLY100D, GLY121E, GLY178D, GLY188D, GLY188E, GLY40D, GLY51E, GLY52E, HIS108D, HIS156E, HIS210D, ILE113D, ILE187D, ILE187E, ILE92E, LEU103D, LEU117D, LEU117E, LEU161E, LEU168D, LEU184D, LEU184E, LEU202D, LEU202E, LEU209E, LEU48D, LEU48E, LEU56D, LEU62D, LEU80E, LEU91E, LYS110D, LYS115D, LYS115E, LYS155E, LYS180D, LYS44D, LYS84E, MET171D, MET175D, PHE128E, PHE181D, PHE201D, PHE55D, PHE69E, PHE99D, PRO101D, PRO153E, PRO39D, PRO96E, SER173D, SER176D, SER186D, SER186E, SER189D, SER206D, SER206E, SER33E, SER43D, SER82E, THR149E, THR169D, THR174D, THR53D, THR53E, THR57D, THR58D, THR61D, THR97E, TRP179D, TRP179E, TRP45D, TYR158E, TYR54D, TYR54E, TYR90E, TYR98E, VAL112D, VAL122E, VAL154E, VAL157E, VAL160E, VAL172D, VAL185D, VAL185E, VAL204D, VAL204E, VAL205D, VAL205E, VAL46D, VAL50E