3DKT

crystal structure of thermotoga maritima encapsulin

• Total interactions analyzed: 190
• Total true interactions: 33
• Strongest Interaction:
  • Chains: D-I
  • Int. Res.: 130
  • Norm. En. per Res.: -3.6891
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-55.2365	-40.9217	-269.054	-365.2122	125	19	3	11835	7	64	72
A-C	0.0	0.0	-0.0409	-0.0409	5	0	0	17	0	0	1
A-D	0.0	0.0	-0.034	-0.034	5	0	0	14	0	0	1
A-E	-49.0386	-40.1375	-250.273	-339.4491	124	14	3	11314	6	61	69
A-K	-15.4275	13.1087	-145.044	-147.3628	60	12	6	6939	1	18	17
B-C	-53.4091	-43.2664	-278.251	-374.9265	128	16	3	12130	6	64	71
B-D	0.0	0.0	-0.0204	-0.0204	4	0	0	8	0	0	1
B-E	0.0	0.0	-0.0179	-0.0179	4	0	0	6	0	0	1
B-L	-14.7341	11.9429	-141.456	-144.2472	61	12	6	6941	1	18	17
C-D	-50.9686	-31.5686	-245.477	-328.0142	119	14	3	11123	6	58	70
C-E	0.0	0.0	-0.0247	-0.0247	4	0	0	10	0	0	1
C-I	-33.5648	-24.4102	-106.958	-164.933	57	9	0	4662	5	34	34
C-M	-16.0979	13.281	-141.59	-144.407	60	11	6	6945	0	18	16
D-E	-54.0841	-42.6005	-285.174	-381.8586	128	18	3	12480	7	64	73
D-H	-30.0819	-22.9761	-115.88	-168.938	57	9	0	4688	4	34	34
D-I	-89.8277	-58.5098	-331.245	-479.5825	130	15	17	15145	2	53	42
D-N	-24.2663	12.2525	-142.572	-154.5858	61	12	6	6909	1	18	16
E-O	-14.9578	7.248	-140.979	-148.6888	61	10	6	6953	1	19	17
F-G	-50.0682	-36.8402	-280.591	-367.4995	125	19	3	12358	6	64	74
F-H	0.0	0.0	-0.0547	-0.0547	5	0	0	18	0	0	2
F-I	0.0	0.0	-0.0346	-0.0346	4	0	0	14	0	0	1
F-J	-52.7318	-40.9275	-258.794	-352.4533	125	21	3	11895	7	63	72
F-P	-15.0824	12.2261	-142.1	-144.9562	61	10	6	6946	1	19	17
G-H	-56.6102	-41.6679	-254.08	-352.3581	123	17	3	11467	5	61	70
G-I	0.0	0.0	-0.0269	-0.0269	4	0	0	11	0	0	1
G-J	0.0	0.0	-0.0742	-0.0742	5	0	0	20	0	0	1
G-Q	-15.1696	12.8332	-140.54	-142.8764	61	14	6	6910	1	18	17
H-I	-55.6365	-43.4099	-267.962	-367.0085	126	18	3	11851	6	63	71
H-J	0.0	0.0	-0.0718	-0.0718	5	0	0	23	0	0	1
H-R	-15.3679	12.7987	-140.922	-143.4912	61	12	6	6951	1	18	17
I-J	-48.8669	-45.0596	-282.341	-376.2675	127	22	3	12350	7	64	74
I-S	-15.2746	12.2322	-146.602	-149.6444	61	13	6	6959	0	19	17
J-T	-15.2489	12.6599	-142.582	-145.171	61	10	6	6946	1	18	17

Interface residues

• A-B: ALA154B, ALA158B, ALA188A, ALA262B, ALA26A, ARG112A, ARG140B, ARG157B, ARG196A, ARG196B, ARG202B, ARG211A, ARG221B, ARG25A, ARG27A, ARG73B, ARG97A, ASN101A, ASN182A, ASN24A, ASN259B, ASN94A, ASP150B, ASP165B, ASP178A, ASP224B, ASP93A, CYS200B, GLN256B, GLN33A, GLU108A, GLU109A, GLU116A, GLU153B, GLU168B, GLU186A, GLU187A, GLU187B, GLU194A, GLU199B, GLU21A, GLU261B, GLU28A, GLU43B, GLU57B, GLU91A, GLU96A, GLY145B, GLY166B, GLY169B, GLY189A, GLY189B, GLY223B, GLY56B, GLY71B, GLY98A, HIS190A, HIS190B, HIS53B, ILE155B, ILE161B, ILE167B, ILE181A, ILE206A, ILE207A, ILE228B, ILE29A, LEU104A, LEU151B, LEU152B, LEU159B, LEU184A, LEU193A, LEU193B, LEU201B, LEU55B, LEU76B, LEU95A, LYS113A, LYS149B, LYS164B, LYS185A, LYS195A, LYS195B, LYS226B, LYS31A, LYS38A, LYS69B, LYS74B, LYS99A, PHE137B, PHE162B, PHE183A, PHE30A, PRO100A, PRO148B, PRO192A, PRO192B, PRO210A, PRO260B, PRO54B, SER105A, SER160B, SER163B, SER219B, THR147B, THR177A, THR208A, THR209A, THR32A, TRP180A, TRP70B, TRP90A, TYR171B, TYR191A, TYR191B, TYR35A, VAL102A, VAL111A, VAL156B, VAL197B, VAL257B, VAL258B, VAL58B, VAL60B
• A-C: HIS190A, HIS190C, PRO192A, TYR191A, TYR191C
• A-D: HIS190A, HIS190D, PRO192D, TYR191A, TYR191D
• A-E: ALA154A, ALA158A, ALA188E, ALA262A, ALA26E, ARG112E, ARG140A, ARG157A, ARG196A, ARG196E, ARG202A, ARG211E, ARG221A, ARG25E, ARG27E, ARG73A, ARG97E, ASN101E, ASN182E, ASN24E, ASN259A, ASN94E, ASP150A, ASP165A, ASP178E, ASP224A, ASP93E, CYS200A, GLN256A, GLN33E, GLU108E, GLU109E, GLU116E, GLU153A, GLU168A, GLU186E, GLU187A, GLU187E, GLU194E, GLU199A, GLU21E, GLU261A, GLU28E, GLU43A, GLU57A, GLU91E, GLU96E, GLY145A, GLY166A, GLY169A, GLY189A, GLY189E, GLY223A, GLY56A, GLY71A, GLY98E, HIS190A, HIS190E, HIS53A, ILE155A, ILE161A, ILE167A, ILE181E, ILE206E, ILE207E, ILE228A, ILE29E, LEU104E, LEU151A, LEU152A, LEU159A, LEU184E, LEU193A, LEU193E, LEU201A, LEU55A, LEU95E, LYS113E, LYS149A, LYS164A, LYS185E, LYS195A, LYS195E, LYS226A, LYS31E, LYS38E, LYS69A, LYS74A, LYS99E, PHE137A, PHE162A, PHE183E, PHE30E, PRO100E, PRO148A, PRO192A, PRO192E, PRO210E, PRO260A, PRO54A, SER105E, SER160A, SER163A, SER219A, THR147A, THR177E, THR208E, THR209E, THR32E, TRP180E, TRP70A, TRP90E, TYR171A, TYR191A, TYR191E, TYR35E, VAL102E, VAL111E, VAL156A, VAL197A, VAL257A, VAL258A, VAL58A, VAL60A
• A-K: ALA26A, ARG112K, ARG25A, ARG27A, ARG37A, ARG9A, ASN24A, ASP108K, ASP232A, ASP23A, ASP41A, GLN20A, GLN231A, GLN33A, GLU118A, GLU16A, GLU220A, GLU251A, GLU28A, GLU43A, GLU5A, GLY106K, GLY107K, GLY110K, GLY230A, GLY236A, GLY36A, GLY44A, ILE111K, ILE207A, ILE22A, ILE235A, ILE249A, ILE29A, LEU107A, LEU109K, LEU227A, LEU229A, LEU233A, LEU34A, LEU7A, LYS113K, LYS205A, LYS31A, LYS38A, MET4A, PHE30A, PHE39A, PHE6A, PRO45A, SER10A, SER234A, THR250A, THR32A, TRP19A, TYR35A, TYR46A, VAL111A, VAL40A, VAL42A
• B-C: ALA154C, ALA158C, ALA188B, ALA262C, ALA26B, ARG112B, ARG140C, ARG157C, ARG196B, ARG196C, ARG202C, ARG211B, ARG221C, ARG25B, ARG27B, ARG73C, ARG97B, ASN101B, ASN182B, ASN24B, ASN259C, ASN94B, ASP150C, ASP165C, ASP178B, ASP224C, ASP93B, CYS200C, GLN256C, GLN33B, GLU108B, GLU109B, GLU116B, GLU153C, GLU168C, GLU186B, GLU186C, GLU187B, GLU187C, GLU194B, GLU199C, GLU21B, GLU261C, GLU28B, GLU43C, GLU57C, GLU91B, GLU96B, GLY145C, GLY166C, GLY169C, GLY189B, GLY189C, GLY223C, GLY56C, GLY71C, GLY98B, HIS190B, HIS190C, HIS53C, ILE155C, ILE161C, ILE167C, ILE181B, ILE206B, ILE207B, ILE228C, ILE29B, LEU104B, LEU151C, LEU152C, LEU159C, LEU184B, LEU193B, LEU193C, LEU201C, LEU34B, LEU55C, LEU72C, LEU76C, LEU95B, LYS113B, LYS149C, LYS164C, LYS185B, LYS195B, LYS195C, LYS226C, LYS31B, LYS38B, LYS69C, LYS74C, LYS99B, PHE137C, PHE162C, PHE183B, PHE30B, PRO100B, PRO148C, PRO192B, PRO192C, PRO210B, PRO260C, PRO54C, SER105B, SER160C, SER163C, SER219C, THR147C, THR177B, THR208B, THR209B, THR32B, TRP180B, TRP70C, TRP90B, TYR171C, TYR191B, TYR191C, TYR35B, VAL102B, VAL111B, VAL156C, VAL197C, VAL257C, VAL258C, VAL58C, VAL60C
• B-D: HIS190B, HIS190D, TYR191B, TYR191D
• B-E: HIS190B, HIS190E, TYR191B, TYR191E
• B-L: ALA26B, ARG112L, ARG25B, ARG27B, ARG37B, ARG9B, ASN24B, ASP108L, ASP232B, ASP23B, ASP41B, GLN20B, GLN231B, GLN33B, GLU118B, GLU16B, GLU220B, GLU251B, GLU28B, GLU43B, GLU5B, GLY106L, GLY107L, GLY110L, GLY230B, GLY236B, GLY36B, GLY44B, ILE111L, ILE207B, ILE22B, ILE235B, ILE249B, ILE29B, LEU107B, LEU109L, LEU227B, LEU229B, LEU233B, LEU34B, LEU7B, LYS113L, LYS205B, LYS31B, LYS38B, MET4B, PHE248B, PHE30B, PHE39B, PHE6B, PRO45B, SER10B, SER234B, THR250B, THR32B, TRP19B, TYR35B, TYR46B, VAL111B, VAL40B, VAL42B
• C-D: ALA154D, ALA158D, ALA188C, ALA262D, ALA26C, ARG112C, ARG140D, ARG157D, ARG196C, ARG196D, ARG202D, ARG211C, ARG221D, ARG25C, ARG27C, ARG73D, ARG97C, ASN101C, ASN182C, ASN24C, ASN259D, ASN94C, ASP150D, ASP165D, ASP178C, ASP224D, ASP93C, CYS200D, GLN256D, GLN33C, GLU108C, GLU109C, GLU116C, GLU153D, GLU168D, GLU186C, GLU187C, GLU187D, GLU194C, GLU199D, GLU21C, GLU261D, GLU28C, GLU43D, GLU57D, GLU91C, GLU96C, GLY166D, GLY169D, GLY189C, GLY189D, GLY223D, GLY56D, GLY71D, GLY98C, HIS190C, HIS190D, HIS53D, ILE161D, ILE167D, ILE181C, ILE228D, ILE29C, LEU104C, LEU151D, LEU152D, LEU159D, LEU184C, LEU193C, LEU193D, LEU201D, LEU55D, LEU95C, LYS113C, LYS149D, LYS164D, LYS185C, LYS195C, LYS195D, LYS226D, LYS31C, LYS38C, LYS69D, LYS74D, LYS99C, PHE137D, PHE162D, PHE183C, PHE30C, PRO100C, PRO148D, PRO192C, PRO192D, PRO210C, PRO260D, PRO54D, SER105C, SER160D, SER163D, SER219D, THR147D, THR177C, THR208C, THR209C, THR32C, TRP180C, TRP70D, TRP90C, TYR171D, TYR191C, TYR191D, TYR35C, VAL102C, VAL111C, VAL156D, VAL257D, VAL258D, VAL58D, VAL60D
• C-E: HIS190C, HIS190E, TYR191C, TYR191E
• C-I: ALA12C, ALA12I, ALA51I, ARG240C, ARG240I, ARG246I, ARG82I, ARG97C, ARG9C, ARG9I, ASN94C, ASP239I, ASP243C, ASP93C, GLN18C, GLU16C, GLU238I, GLU241C, GLU241I, GLU49I, GLU5I, GLU80I, GLU91C, GLU96C, GLY98C, LEU14C, LEU7I, LEU81I, LEU89C, LEU92C, LEU95C, LYS17C, LYS242C, LYS242I, LYS8C, LYS8I, LYS99C, MET4I, PHE11C, PHE11I, PHE248I, PHE6I, PRO13C, PRO13I, SER10C, SER10I, THR15C, THR250I, THR252I, THR84I, TRP19C, TRP48I, TRP90C, TYR237C, TYR237I, TYR50I, VAL245C
• C-M: ALA26C, ARG112M, ARG25C, ARG27C, ARG37C, ARG9C, ASN24C, ASP108M, ASP232C, ASP23C, ASP41C, GLN20C, GLN231C, GLN33C, GLU118C, GLU16C, GLU220C, GLU251C, GLU28C, GLU43C, GLU5C, GLY106M, GLY107M, GLY110M, GLY230C, GLY236C, GLY36C, GLY44C, ILE111M, ILE207C, ILE22C, ILE235C, ILE249C, ILE29C, LEU107C, LEU109M, LEU227C, LEU229C, LEU233C, LEU34C, LEU7C, LYS113M, LYS205C, LYS31C, LYS38C, MET4C, PHE30C, PHE39C, PHE6C, PRO45C, SER10C, SER234C, THR250C, THR32C, TRP19C, TYR35C, TYR46C, VAL111C, VAL40C, VAL42C
• D-E: ALA154E, ALA158E, ALA188D, ALA262E, ALA26D, ARG112D, ARG140E, ARG157E, ARG196D, ARG196E, ARG202E, ARG211D, ARG221E, ARG25D, ARG27D, ARG73E, ARG97D, ASN101D, ASN182D, ASN24D, ASN259E, ASN94D, ASP150E, ASP165E, ASP178D, ASP224E, ASP93D, CYS200E, GLN256E, GLN33D, GLU108D, GLU109D, GLU116D, GLU153E, GLU168E, GLU186D, GLU186E, GLU187D, GLU187E, GLU194D, GLU199E, GLU21D, GLU261E, GLU28D, GLU43E, GLU57E, GLU91D, GLU96D, GLY145E, GLY166E, GLY169E, GLY189D, GLY189E, GLY223E, GLY56E, GLY71E, GLY98D, HIS190D, HIS190E, HIS53E, ILE155E, ILE161E, ILE167E, ILE181D, ILE206D, ILE207D, ILE228E, ILE29D, LEU104D, LEU151E, LEU152E, LEU159E, LEU184D, LEU193D, LEU193E, LEU201E, LEU34D, LEU55E, LEU72E, LEU76E, LEU95D, LYS113D, LYS149E, LYS164E, LYS185D, LYS195D, LYS195E, LYS226E, LYS31D, LYS38D, LYS69E, LYS74E, LYS99D, PHE137E, PHE162E, PHE183D, PHE30D, PRO100D, PRO148E, PRO192D, PRO192E, PRO210D, PRO260E, PRO54E, SER105D, SER160E, SER163E, SER219E, THR147E, THR177D, THR208D, THR209D, THR32D, TRP180D, TRP70E, TRP90D, TYR171E, TYR191D, TYR191E, TYR35D, VAL102D, VAL111D, VAL156E, VAL197E, VAL257E, VAL258E, VAL58E, VAL60E
• D-H: ALA12D, ALA12H, ALA51D, ARG240D, ARG240H, ARG246D, ARG82D, ARG97H, ARG9D, ARG9H, ASN94H, ASP239D, ASP243H, ASP93H, GLN18H, GLU16H, GLU238D, GLU241D, GLU241H, GLU49D, GLU5D, GLU80D, GLU91H, GLU96H, GLY98H, LEU14H, LEU7D, LEU81D, LEU89H, LEU92H, LEU95H, LYS17H, LYS242D, LYS242H, LYS8D, LYS8H, LYS99H, MET4D, PHE11D, PHE11H, PHE248D, PHE6D, PRO13D, PRO13H, SER10D, SER10H, THR15H, THR250D, THR252D, THR84D, TRP19H, TRP48D, TRP90H, TYR237D, TYR237H, TYR50D, VAL245H
• D-I: ALA115D, ALA115I, ALA51D, ALA51I, ALA52D, ALA52I, ALA83D, ALA83I, ARG112D, ARG112I, ARG73D, ARG73I, ARG82D, ARG82I, ASP63D, ASP63I, CYS126D, CYS126I, GLN231D, GLN231I, GLU109D, GLU109I, GLU116D, GLU116I, GLU118D, GLU118I, GLU120D, GLU120I, GLU127D, GLU127I, GLU251D, GLU251I, GLU49D, GLU49I, GLU57D, GLU57I, GLU59D, GLU59I, GLU66D, GLU66I, GLU80D, GLU80I, GLY130D, GLY130I, GLY230D, GLY230I, GLY47D, GLY47I, GLY56D, GLY56I, GLY71D, GLY71I, HIS53D, HIS53I, ILE249D, ILE249I, ILE79D, ILE79I, LEU55D, LEU55I, LEU61D, LEU61I, LEU72D, LEU72I, LEU76D, LEU76I, LEU78D, LEU78I, LEU81D, LEU81I, LYS113D, LYS113I, LYS128D, LYS128I, LYS69D, LYS69I, LYS74D, LYS74I, PHE117D, PHE117I, PHE253D, PHE253I, PHE30D, PHE30I, PHE6D, PHE6I, PHE85D, PHE85I, PRO54D, PRO54I, PRO77D, PRO77I, SER129D, SER129I, SER62D, SER62I, SER75D, SER75I, THR110D, THR110I, THR250D, THR250I, THR252D, THR252I, THR254D, THR254I, THR84D, THR84I, TRP48D, TRP48I, TRP70D, TRP70I, TYR50D, TYR50I, VAL111D, VAL111I, VAL114D, VAL114I, VAL121D, VAL121I, VAL131D, VAL131I, VAL58D, VAL58I, VAL60D, VAL60I, VAL67D, VAL67I, VAL68D, VAL68I
• D-N: ALA26D, ARG112N, ARG25D, ARG27D, ARG37D, ARG9D, ASN24D, ASP108N, ASP232D, ASP23D, ASP41D, GLN20D, GLN231D, GLN33D, GLU118D, GLU16D, GLU220D, GLU251D, GLU28D, GLU43D, GLU5D, GLY106N, GLY107N, GLY110N, GLY230D, GLY236D, GLY36D, GLY44D, ILE111N, ILE207D, ILE22D, ILE235D, ILE249D, ILE29D, LEU107D, LEU109N, LEU227D, LEU229D, LEU233D, LEU34D, LEU7D, LYS113N, LYS205D, LYS31D, LYS38D, MET4D, PHE248D, PHE30D, PHE39D, PHE6D, PRO45D, SER10D, SER234D, THR250D, THR32D, TRP19D, TYR35D, TYR46D, VAL111D, VAL40D, VAL42D
• E-O: ALA26E, ARG112O, ARG25E, ARG27E, ARG37E, ARG9E, ASN24E, ASP108O, ASP232E, ASP23E, ASP41E, GLN20E, GLN231E, GLN33E, GLU118E, GLU16E, GLU220E, GLU251E, GLU28E, GLU43E, GLU5E, GLY106O, GLY107O, GLY110O, GLY230E, GLY236E, GLY36E, GLY44E, ILE111O, ILE207E, ILE22E, ILE235E, ILE249E, ILE29E, LEU107E, LEU109O, LEU227E, LEU229E, LEU233E, LEU34E, LEU7E, LYS113O, LYS205E, LYS31E, LYS38E, MET4E, PHE248E, PHE30E, PHE39E, PHE6E, PRO45E, SER10E, SER234E, THR250E, THR32E, TRP19E, TYR35E, TYR46E, VAL111E, VAL40E, VAL42E
• F-G: ALA154G, ALA158G, ALA188F, ALA262G, ALA26F, ARG112F, ARG140G, ARG157G, ARG196F, ARG196G, ARG202G, ARG211F, ARG221G, ARG25F, ARG27F, ARG73G, ARG97F, ASN101F, ASN182F, ASN24F, ASN259G, ASN94F, ASP150G, ASP165G, ASP178F, ASP224G, ASP93F, CYS200G, GLN256G, GLN33F, GLU108F, GLU109F, GLU116F, GLU153G, GLU168G, GLU186F, GLU186G, GLU187F, GLU187G, GLU194F, GLU199G, GLU21F, GLU261G, GLU28F, GLU43G, GLU57G, GLU91F, GLU96F, GLY145G, GLY166G, GLY169G, GLY189F, GLY189G, GLY223G, GLY56G, GLY71G, GLY98F, HIS190F, HIS190G, HIS53G, ILE155G, ILE161G, ILE167G, ILE181F, ILE206F, ILE207F, ILE228G, ILE29F, LEU104F, LEU151G, LEU152G, LEU159G, LEU184F, LEU193F, LEU193G, LEU201G, LEU34F, LEU55G, LEU95F, LYS113F, LYS149G, LYS164G, LYS185F, LYS195F, LYS195G, LYS226G, LYS31F, LYS38F, LYS69G, LYS74G, LYS99F, PHE137G, PHE162G, PHE183F, PHE30F, PRO100F, PRO148G, PRO192F, PRO192G, PRO210F, PRO260G, PRO54G, SER105F, SER160G, SER163G, THR147G, THR177F, THR208F, THR209F, THR32F, TRP180F, TRP70G, TRP90F, TYR171G, TYR191F, TYR191G, TYR35F, VAL102F, VAL111F, VAL156G, VAL197G, VAL257G, VAL258G, VAL58G, VAL60G
• F-H: HIS190F, HIS190H, PRO192F, TYR191F, TYR191H
• F-I: HIS190F, HIS190I, TYR191F, TYR191I
• F-J: ALA154F, ALA158F, ALA188J, ALA262F, ALA26J, ARG112J, ARG140F, ARG157F, ARG196F, ARG196J, ARG202F, ARG211J, ARG221F, ARG25J, ARG27J, ARG73F, ARG97J, ASN101J, ASN182J, ASN24J, ASN259F, ASN94J, ASP150F, ASP165F, ASP178J, ASP224F, ASP93J, CYS200F, GLN256F, GLN33J, GLU108J, GLU109J, GLU116J, GLU153F, GLU168F, GLU186J, GLU187F, GLU187J, GLU194J, GLU199F, GLU21J, GLU261F, GLU28J, GLU43F, GLU57F, GLU91J, GLU96J, GLY145F, GLY166F, GLY169F, GLY189F, GLY189J, GLY223F, GLY56F, GLY71F, GLY98J, HIS190F, HIS190J, HIS53F, ILE155F, ILE161F, ILE167F, ILE181J, ILE206J, ILE207J, ILE228F, ILE29J, LEU104J, LEU151F, LEU152F, LEU159F, LEU184J, LEU193F, LEU193J, LEU201F, LEU34J, LEU55F, LEU95J, LYS113J, LYS149F, LYS164F, LYS185J, LYS195F, LYS195J, LYS226F, LYS31J, LYS38J, LYS69F, LYS74F, LYS99J, PHE137F, PHE162F, PHE183J, PHE30J, PRO100J, PRO148F, PRO192F, PRO192J, PRO210J, PRO260F, PRO54F, SER105J, SER160F, SER163F, SER219F, THR147F, THR177J, THR208J, THR209J, THR32J, TRP180J, TRP70F, TRP90J, TYR171F, TYR191F, TYR191J, TYR35J, VAL102J, VAL111J, VAL156F, VAL197F, VAL257F, VAL258F, VAL58F, VAL60F
• F-P: ALA26F, ARG112P, ARG25F, ARG27F, ARG37F, ARG9F, ASN24F, ASP108P, ASP232F, ASP23F, ASP41F, GLN20F, GLN231F, GLN33F, GLU118F, GLU16F, GLU220F, GLU251F, GLU28F, GLU43F, GLU5F, GLY106P, GLY107P, GLY110P, GLY230F, GLY236F, GLY36F, GLY44F, ILE111P, ILE207F, ILE22F, ILE235F, ILE249F, ILE29F, LEU107F, LEU109P, LEU227F, LEU229F, LEU233F, LEU34F, LEU7F, LYS113P, LYS205F, LYS31F, LYS38F, MET4F, PHE248F, PHE30F, PHE39F, PHE6F, PRO45F, SER10F, SER234F, THR250F, THR32F, TRP19F, TYR35F, TYR46F, VAL111F, VAL40F, VAL42F
• G-H: ALA154H, ALA158H, ALA188G, ALA262H, ALA26G, ARG112G, ARG140H, ARG157H, ARG196G, ARG196H, ARG202H, ARG211G, ARG221H, ARG25G, ARG27G, ARG73H, ARG97G, ASN101G, ASN182G, ASN24G, ASN259H, ASN94G, ASP150H, ASP165H, ASP178G, ASP224H, ASP93G, CYS200H, GLN256H, GLN33G, GLU108G, GLU109G, GLU116G, GLU153H, GLU168H, GLU186G, GLU187G, GLU187H, GLU194G, GLU199H, GLU21G, GLU261H, GLU28G, GLU43H, GLU57H, GLU91G, GLU96G, GLY145H, GLY166H, GLY169H, GLY189G, GLY189H, GLY223H, GLY56H, GLY71H, GLY98G, HIS190G, HIS190H, HIS53H, ILE155H, ILE161H, ILE167H, ILE181G, ILE206G, ILE207G, ILE228H, ILE29G, LEU104G, LEU151H, LEU152H, LEU159H, LEU184G, LEU193G, LEU193H, LEU201H, LEU55H, LEU95G, LYS113G, LYS149H, LYS164H, LYS185G, LYS195G, LYS195H, LYS226H, LYS31G, LYS38G, LYS69H, LYS74H, LYS99G, PHE137H, PHE162H, PHE183G, PHE30G, PRO100G, PRO148H, PRO192G, PRO192H, PRO210G, PRO260H, PRO54H, SER105G, SER160H, SER163H, THR147H, THR177G, THR208G, THR209G, THR32G, TRP180G, TRP70H, TRP90G, TYR171H, TYR191G, TYR191H, TYR35G, VAL102G, VAL111G, VAL156H, VAL197H, VAL257H, VAL258H, VAL58H, VAL60H
• G-I: HIS190G, HIS190I, TYR191G, TYR191I
• G-J: HIS190G, HIS190J, PRO192J, TYR191G, TYR191J
• G-Q: ALA26G, ARG112Q, ARG25G, ARG27G, ARG37G, ARG9G, ASN24G, ASP108Q, ASP232G, ASP23G, ASP41G, GLN20G, GLN231G, GLN33G, GLU118G, GLU16G, GLU220G, GLU251G, GLU28G, GLU43G, GLU5G, GLY106Q, GLY107Q, GLY110Q, GLY230G, GLY236G, GLY36G, GLY44G, ILE111Q, ILE207G, ILE22G, ILE235G, ILE249G, ILE29G, LEU107G, LEU109Q, LEU227G, LEU229G, LEU233G, LEU34G, LEU7G, LYS113Q, LYS205G, LYS31G, LYS38G, MET4G, PHE248G, PHE30G, PHE39G, PHE6G, PRO45G, SER10G, SER234G, THR250G, THR32G, TRP19G, TYR35G, TYR46G, VAL111G, VAL40G, VAL42G
• H-I: ALA154I, ALA158I, ALA188H, ALA262I, ALA26H, ARG112H, ARG140I, ARG157I, ARG196H, ARG196I, ARG202I, ARG211H, ARG221I, ARG25H, ARG27H, ARG73I, ARG97H, ASN101H, ASN182H, ASN24H, ASN259I, ASN94H, ASP150I, ASP165I, ASP178H, ASP224I, ASP93H, CYS200I, GLN256I, GLN33H, GLU108H, GLU109H, GLU116H, GLU153I, GLU168I, GLU186H, GLU186I, GLU187H, GLU187I, GLU194H, GLU199I, GLU21H, GLU261I, GLU28H, GLU43I, GLU57I, GLU91H, GLU96H, GLY145I, GLY166I, GLY169I, GLY189H, GLY189I, GLY223I, GLY56I, GLY71I, GLY98H, HIS190H, HIS190I, HIS53I, ILE155I, ILE161I, ILE167I, ILE181H, ILE206H, ILE207H, ILE228I, ILE29H, LEU104H, LEU151I, LEU152I, LEU159I, LEU184H, LEU193H, LEU193I, LEU201I, LEU34H, LEU55I, LEU95H, LYS113H, LYS149I, LYS164I, LYS185H, LYS195H, LYS195I, LYS226I, LYS31H, LYS38H, LYS69I, LYS74I, LYS99H, PHE137I, PHE162I, PHE183H, PHE30H, PRO100H, PRO148I, PRO192H, PRO192I, PRO210H, PRO260I, PRO54I, SER105H, SER160I, SER163I, SER219I, THR147I, THR177H, THR208H, THR209H, THR32H, TRP180H, TRP70I, TRP90H, TYR171I, TYR191H, TYR191I, TYR35H, VAL102H, VAL111H, VAL156I, VAL197I, VAL257I, VAL258I, VAL58I, VAL60I
• H-J: HIS190H, HIS190J, PRO192H, TYR191H, TYR191J
• H-R: ALA26H, ARG112R, ARG25H, ARG27H, ARG37H, ARG9H, ASN24H, ASP108R, ASP232H, ASP23H, ASP41H, GLN20H, GLN231H, GLN33H, GLU118H, GLU16H, GLU220H, GLU251H, GLU28H, GLU43H, GLU5H, GLY106R, GLY107R, GLY110R, GLY230H, GLY236H, GLY36H, GLY44H, ILE111R, ILE207H, ILE22H, ILE235H, ILE249H, ILE29H, LEU107H, LEU109R, LEU227H, LEU229H, LEU233H, LEU34H, LEU7H, LYS113R, LYS205H, LYS31H, LYS38H, MET4H, PHE248H, PHE30H, PHE39H, PHE6H, PRO45H, SER10H, SER234H, THR250H, THR32H, TRP19H, TYR35H, TYR46H, VAL111H, VAL40H, VAL42H
• I-J: ALA154J, ALA158J, ALA188I, ALA262J, ALA26I, ARG112I, ARG140J, ARG157J, ARG196I, ARG196J, ARG202J, ARG211I, ARG221J, ARG25I, ARG27I, ARG73J, ARG97I, ASN101I, ASN182I, ASN24I, ASN259J, ASN94I, ASP150J, ASP165J, ASP178I, ASP224J, ASP93I, CYS200J, GLN256J, GLN33I, GLU108I, GLU109I, GLU116I, GLU153J, GLU168J, GLU186I, GLU186J, GLU187I, GLU187J, GLU194I, GLU199J, GLU21I, GLU261J, GLU28I, GLU43J, GLU57J, GLU91I, GLU96I, GLY145J, GLY166J, GLY169J, GLY189I, GLY189J, GLY223J, GLY56J, GLY71J, GLY98I, HIS190I, HIS190J, HIS53J, ILE155J, ILE161J, ILE167J, ILE181I, ILE206I, ILE207I, ILE228J, ILE29I, LEU104I, LEU151J, LEU152J, LEU159J, LEU184I, LEU193I, LEU193J, LEU201J, LEU34I, LEU55J, LEU76J, LEU95I, LYS113I, LYS149J, LYS164J, LYS185I, LYS195I, LYS195J, LYS226J, LYS31I, LYS38I, LYS69J, LYS74J, LYS99I, PHE137J, PHE162J, PHE183I, PHE30I, PRO100I, PRO148J, PRO192I, PRO192J, PRO210I, PRO260J, PRO54J, SER105I, SER160J, SER163J, SER219J, THR147J, THR177I, THR208I, THR209I, THR32I, TRP180I, TRP70J, TRP90I, TYR171J, TYR191I, TYR191J, TYR35I, VAL102I, VAL111I, VAL156J, VAL197J, VAL257J, VAL258J, VAL58J, VAL60J
• I-S: ALA26I, ARG112S, ARG25I, ARG27I, ARG37I, ARG9I, ASN24I, ASP108S, ASP232I, ASP23I, ASP41I, GLN20I, GLN231I, GLN33I, GLU118I, GLU16I, GLU220I, GLU251I, GLU28I, GLU43I, GLU5I, GLY106S, GLY107S, GLY110S, GLY230I, GLY236I, GLY36I, GLY44I, ILE111S, ILE207I, ILE22I, ILE235I, ILE249I, ILE29I, LEU107I, LEU109S, LEU227I, LEU229I, LEU233I, LEU34I, LEU7I, LYS113S, LYS205I, LYS31I, LYS38I, MET4I, PHE248I, PHE30I, PHE39I, PHE6I, PRO45I, SER10I, SER234I, THR250I, THR32I, TRP19I, TYR35I, TYR46I, VAL111I, VAL40I, VAL42I
• J-T: ALA26J, ARG112T, ARG25J, ARG27J, ARG37J, ARG9J, ASN24J, ASP108T, ASP232J, ASP23J, ASP41J, GLN20J, GLN231J, GLN33J, GLU118J, GLU16J, GLU220J, GLU251J, GLU28J, GLU43J, GLU5J, GLY106T, GLY107T, GLY110T, GLY230J, GLY236J, GLY36J, GLY44J, ILE111T, ILE207J, ILE22J, ILE235J, ILE249J, ILE29J, LEU107J, LEU109T, LEU227J, LEU229J, LEU233J, LEU34J, LEU7J, LYS113T, LYS205J, LYS31J, LYS38J, MET4J, PHE248J, PHE30J, PHE39J, PHE6J, PRO45J, SER10J, SER234J, THR250J, THR32J, TRP19J, TYR35J, TYR46J, VAL111J, VAL40J, VAL42J