3DAC

structure of the human mdmx protein bound to the p53 tumor suppressor transactivation domain

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 54
  • Norm. En. per Res.: -3.2791
• Hub Node: M(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
M-P	-17.4916	0.0	-144.613	-162.1046	50	5	4	5716	0	9	7
M-A	-14.5467	0.0	-57.0961	-71.6428	36	10	0	2041	0	2	6
M-B	-9.2458	-2.1251	-12.6914	-24.0623	17	1	0	788	0	2	2
P-A	0.0	-4.2912	-15.1248	-19.416	18	1	0	924	0	1	2
A-B	-12.3684	0.0	-164.704	-177.0724	54	2	4	6132	0	13	8

Interface residues

• M-P: ARG67M, ASN91M, ASP21P, ASP64M, GLN55M, GLN61M, GLN66M, GLN68M, GLU17P, GLU28P, GLU48M, GLY54M, HIS51M, HIS69M, ILE57M, ILE70M, LEU22P, LEU25P, LEU26P, LEU53M, LEU62M, LEU78M, LEU82M, LEU95M, LEU99M, LYS24P, LYS47M, LYS65M, LYS90M, MET50M, MET58M, MET59M, MET98M, PHE19P, PHE87M, PRO27P, PRO92M, SER20P, SER88M, SER93M, THR18P, TRP23P, TYR52M, TYR56M, TYR63M, TYR96M, VAL46M, VAL49M, VAL71M, VAL89M
• M-A: ALA37A, ALA37M, ARG67M, ASP64A, ASP64M, GLN40A, GLN40M, GLN55A, GLN55M, GLN61A, GLN61M, GLN66A, GLN66M, GLN68A, GLN68M, GLY38A, GLY38M, GLY54A, GLY54M, HIS51A, HIS51M, ILE57M, LYS47A, LYS47M, LYS60A, LYS60M, LYS65A, LYS65M, MET58A, MET58M, MET59A, MET59M, TYR52A, TYR52M, TYR63A, TYR63M
• M-B: ALA37M, ASP21B, GLN55M, GLN61M, GLU17B, GLY38M, LEU22B, LYS24B, LYS35M, LYS60M, MET58M, MET59M, PHE19B, SER20B, THR18B, TRP23B, VAL36M
• P-A: ALA37A, ASP21P, GLN55A, GLN61A, GLU17P, GLY38A, LEU22P, LYS24P, LYS35A, LYS60A, LYS65A, MET58A, MET59A, PHE19P, SER20P, THR18P, TRP23P, VAL36A
• A-B: ARG67A, ASN29B, ASN91A, ASP21B, ASP64A, GLN55A, GLN61A, GLN66A, GLN68A, GLU17B, GLU28B, GLU48A, GLU97A, GLY54A, HIS51A, HIS69A, ILE57A, ILE70A, LEU22B, LEU25B, LEU26B, LEU53A, LEU62A, LEU78A, LEU82A, LEU95A, LEU99A, LYS100A, LYS24B, LYS47A, LYS65A, LYS90A, MET50A, MET58A, MET59A, MET98A, PHE19B, PHE87A, PRO27B, PRO92A, SER20B, SER88A, SER93A, THR18B, THR45A, TRP23B, TYR52A, TYR56A, TYR63A, TYR96A, VAL46A, VAL49A, VAL71A, VAL89A