3DAB

structure of the human mdmx protein bound to the p53 tumor suppressor transactivation domain

• Total interactions analyzed: 28
• Total true interactions: 10
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 51
  • Norm. En. per Res.: -3.9632
• Hub Node: C(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-11.8074	-2.3337	-162.063	-176.2041	54	5	4	6049	0	9	11
A-G	-6.6553	-49.4696	-5.4883	-61.6132	31	7	0	827	2	10	11
B-E	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	1	1
C-D	-12.0259	0.5185	-137.582	-149.0894	51	2	3	5361	0	6	9
C-E	-18.025	0.0	-20.2449	-38.2699	26	1	0	812	0	4	4
C-G	-21.4641	-27.478	-74.3338	-123.276	42	5	1	3039	1	9	16
E-F	-34.3545	-20.0324	-147.738	-202.1249	51	6	3	5790	2	6	9
E-G	-11.3794	0.0	-72.1684	-83.5478	38	1	1	3266	0	6	9
F-G	0.0	8.3761	-21.5486	-13.1725	19	0	0	695	0	2	5
G-H	-13.9265	0.5097	-163.737	-177.1538	53	5	4	5930	0	7	8

Interface residues

• A-B: ARG103A, ASP21B, ASP67A, ASP94A, GLN26A, GLN58A, GLN64A, GLN68A, GLN69A, GLN71A, GLU17B, GLU28B, GLU51A, GLU70A, GLY57A, HIS54A, HIS72A, ILE60A, LEU102A, LEU22B, LEU25B, LEU26B, LEU37A, LEU56A, LEU65A, LEU81A, LEU85A, LEU98A, LYS24B, LYS50A, LYS93A, MET101A, MET53A, MET61A, MET73A, PHE19B, PHE90A, PRO27B, PRO95A, SER20B, SER91A, SER96A, THR18B, THR48A, TRP23B, TYR55A, TYR59A, TYR66A, TYR99A, VAL49A, VAL52A, VAL62A, VAL74A, VAL92A
• A-G: ARG87A, ARG87G, ASP100A, ASP100G, ASP94A, ASP94G, GLN88A, GLN88G, GLU70A, GLY86G, HIS72A, HIS72G, LEU98G, LYS93A, LYS93G, MET73A, MET73G, PHE90A, PHE90G, PRO95A, PRO95G, PRO97A, PRO97G, SER89A, SER89G, SER91A, SER91G, SER96A, SER96G, TYR75A, TYR99G
• B-E: LYS50E, PRO27B
• C-D: ARG103C, ASP21D, ASP67C, ASP94C, GLN58C, GLN64C, GLN68C, GLN69C, GLN71C, GLU17D, GLU70C, GLY57C, HIS54C, HIS72C, ILE24C, ILE60C, LEU102C, LEU22D, LEU25D, LEU26D, LEU37C, LEU56C, LEU65C, LEU81C, LEU85C, LEU98C, LYS24D, LYS50C, LYS93C, MET101C, MET53C, MET61C, MET73C, PHE19D, PHE90C, PRO27D, PRO95C, SER20D, SER91C, SER96C, THR18D, TRP23D, TYR55C, TYR59C, TYR66C, TYR99C, VAL49C, VAL52C, VAL62C, VAL74C, VAL92C
• C-E: ASP67C, ASP67E, ASP79C, ASP79E, GLN64C, GLN64E, GLN68C, GLN68E, GLN69C, GLN69E, GLN71E, GLN88C, GLN88E, GLU70C, GLU70E, GLY77C, GLY77E, GLY78C, GLY78E, LEU65C, LYS63C, LYS63E, TYR66E, TYR75C, TYR75E, VAL62C
• C-G: ALA39G, ALA40G, ALA42G, ARG28G, ARG87C, ASP67C, ASP79G, ASP94C, CYS76C, GLN43G, GLN68C, GLN69C, GLN88C, GLU45G, GLU70C, GLY41G, GLY44G, GLY77C, GLY86C, HIS38G, HIS72C, ILE36G, LEU31G, LEU34G, LEU37G, LEU65C, LEU80G, LYS30G, LYS35G, LYS63G, MET46G, MET73C, PHE47G, PHE90C, PRO29G, PRO97C, SER89C, SER91C, TYR59G, TYR66C, TYR75C, VAL74C
• E-F: ASP21F, ASP67E, ASP94E, GLN16F, GLN58E, GLN64E, GLN68E, GLN69E, GLN71E, GLU17F, GLU70E, GLY57E, HIS54E, HIS72E, ILE24E, ILE60E, LEU102E, LEU22F, LEU25F, LEU26F, LEU37E, LEU56E, LEU65E, LEU81E, LEU85E, LEU98E, LYS24F, LYS50E, LYS93E, MET101E, MET53E, MET61E, MET73E, PHE19F, PHE90E, PRO27F, PRO95E, SER20F, SER91E, SER96E, THR18F, TRP23F, TYR55E, TYR59E, TYR66E, TYR99E, VAL49E, VAL52E, VAL62E, VAL74E, VAL92E
• E-G: ALA39E, ALA40E, ALA42E, ASN105G, ASP79G, GLN58E, GLN64E, GLN68E, GLN71E, GLU83G, GLY41E, GLY57E, GLY78G, GLY82G, GLY86G, HIS38E, HIS54E, ILE36G, ILE60E, LEU31G, LEU33G, LEU34G, LEU65E, LEU80G, LEU81G, LEU84G, LEU85G, LYS104G, LYS30G, LYS35G, LYS63E, MET101G, MET61E, PRO32G, TYR55E, TYR59E, TYR66E, VAL62E
• F-G: ARG87G, ASP21F, ASP79G, CYS76G, GLN88G, GLU17F, GLU83G, GLY77G, GLY78G, GLY82G, GLY86G, LEU22F, LEU80G, LEU84G, LYS24F, PHE19F, SER20F, THR18F, TRP23F
• G-H: ARG103G, ASP21H, ASP67G, ASP94G, GLN26G, GLN58G, GLN68G, GLN69G, GLN71G, GLU28H, GLU51G, GLU70G, GLY57G, HIS54G, HIS72G, ILE60G, LEU102G, LEU106G, LEU22H, LEU25H, LEU26H, LEU37G, LEU56G, LEU65G, LEU81G, LEU85G, LEU98G, LYS24H, LYS50G, LYS93G, MET101G, MET53G, MET61G, MET73G, PHE19H, PHE90G, PRO27H, PRO95G, SER20H, SER91G, SER96G, THR18H, THR48G, TRP23H, TYR55G, TYR59G, TYR66G, TYR99G, VAL49G, VAL52G, VAL62G, VAL74G, VAL92G