3D9S

human aquaporin 5 (aqp5) - high resolution x-ray structure

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 151
  • Norm. En. per Res.: -2.6482
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.6667	-0.6667	13	0	0	152	0	0	0
A-C	-10.9517	0.0	-383.256	-394.2077	152	12	19	17618	0	1	0
A-D	-19.3042	0.0	-373.233	-392.5372	149	8	16	17642	0	0	0
B-C	-18.7082	0.0	-369.564	-388.2722	152	19	20	17829	0	0	1
B-D	-25.1966	0.0	-374.686	-399.8826	151	22	19	17834	0	1	0
C-D	0.0	0.0	-0.4203	-0.4203	14	0	0	136	0	0	0

Interface residues

• A-B: GLN44A, GLY159A, GLY159B, LEU163A, LEU163B, LEU167A, LEU167B, LEU43A, LEU43B, LEU47A, LEU47B, SER160A, SER160B
• A-C: ALA109A, ALA113A, ALA131C, ALA13A, ALA143C, ALA148C, ALA162A, ALA162C, ALA16A, ALA20A, ALA217C, ALA32A, ALA38A, ALA46A, ALA46C, ALA48A, ALA52A, ALA57A, ALA59A, ALA9A, ARG114A, ARG154A, ARG154C, ASN112A, ASN123C, ASN124C, ASN125C, ASP151A, ASP151C, CYS145C, CYS182C, GLN130C, GLN141C, GLN44A, GLN44C, GLN58A, GLU135C, GLY101A, GLY107A, GLY129C, GLY159A, GLY159C, GLY166A, GLY166C, GLY172C, GLY176C, GLY28A, GLY30A, GLY50A, GLY50C, GLY54A, GLY61A, GLY65A, HIS173C, ILE104A, ILE137C, ILE146C, ILE165C, ILE177C, ILE23A, ILE42A, ILE42C, ILE45A, ILE53A, LEU105A, LEU111A, LEU136C, LEU138C, LEU142C, LEU144C, LEU163A, LEU163C, LEU167A, LEU167C, LEU171C, LEU174A, LEU174C, LEU19A, LEU216C, LEU220C, LEU224C, LEU225C, LEU22A, LEU29A, LEU33A, LEU39A, LEU43A, LEU43C, LEU47A, LEU47C, LEU51A, LEU56A, LEU60A, LYS12A, LYS34A, MET132C, MET184C, PHE140C, PHE147C, PHE15A, PHE179C, PHE226C, PHE24A, PHE26A, PHE27A, PHE49A, PRO110A, PRO157C, PRO161A, PRO161C, PRO227C, PRO36A, PRO40A, PRO62A, SER149A, SER149C, SER152A, SER156C, SER160A, SER160C, SER164A, SER164C, SER168C, SER31A, SER37A, SER64A, THR126C, THR127C, THR139C, THR150A, THR150C, THR155C, THR170C, THR180C, THR41A, THR41C, THR55A, TRP35A, TYR106A, TYR178C, TYR221C, TYR223C, VAL108A, VAL133C, VAL134C, VAL158A, VAL158C, VAL169C, VAL175C, VAL25A, VAL63A, VAL8A
• A-D: ALA109D, ALA113D, ALA131A, ALA13D, ALA143A, ALA148A, ALA162A, ALA162D, ALA16D, ALA20D, ALA217A, ALA32D, ALA38D, ALA46A, ALA46D, ALA48D, ALA52D, ALA57D, ALA59D, ALA9D, ARG114D, ARG154A, ARG154D, ASN112D, ASN123A, ASN124A, ASN125A, ASP151A, ASP151D, CYS145A, CYS182A, GLN130A, GLN141A, GLN44A, GLN44D, GLN58D, GLU135A, GLY101D, GLY107D, GLY129A, GLY159A, GLY159D, GLY166A, GLY172A, GLY176A, GLY28D, GLY30D, GLY50A, GLY50D, GLY54D, GLY61D, HIS173A, ILE104D, ILE137A, ILE146A, ILE165A, ILE177A, ILE23D, ILE42A, ILE42D, ILE45D, ILE53D, LEU105D, LEU111D, LEU11D, LEU136A, LEU138A, LEU142A, LEU144A, LEU163A, LEU163D, LEU167A, LEU167D, LEU171A, LEU174A, LEU19D, LEU220A, LEU224A, LEU225A, LEU22D, LEU29D, LEU33D, LEU39D, LEU43A, LEU43D, LEU47A, LEU47D, LEU51D, LEU56D, LEU60D, LYS12D, LYS34D, MET132A, MET184A, PHE140A, PHE147A, PHE15D, PHE179A, PHE226A, PHE24D, PHE26D, PHE27D, PHE49D, PRO110D, PRO157A, PRO161A, PRO161D, PRO227A, PRO36D, PRO40A, PRO40D, PRO62D, SER149A, SER149D, SER152D, SER156A, SER160A, SER160D, SER164A, SER164D, SER168A, SER31D, SER37D, SER64D, THR126A, THR127A, THR139A, THR150A, THR150D, THR155A, THR170A, THR41A, THR41D, THR55D, TRP35D, TYR106D, TYR178A, TYR221A, TYR223A, VAL108D, VAL133A, VAL134A, VAL158A, VAL158D, VAL169A, VAL175A, VAL25D, VAL63D, VAL8D
• B-C: ALA109C, ALA113C, ALA131B, ALA13C, ALA143B, ALA148B, ALA162B, ALA162C, ALA16C, ALA20C, ALA217B, ALA32C, ALA38C, ALA46B, ALA46C, ALA48C, ALA52C, ALA57C, ALA59C, ARG114C, ARG154B, ARG154C, ASN112C, ASN123B, ASN124B, ASN125B, ASP151B, ASP151C, CYS145B, CYS182B, GLN128B, GLN130B, GLN141B, GLN44B, GLN44C, GLN58C, GLU135B, GLY101C, GLY107C, GLY129B, GLY159B, GLY159C, GLY166B, GLY166C, GLY172B, GLY176B, GLY28C, GLY30C, GLY50B, GLY50C, GLY54C, GLY61C, GLY65C, HIS173B, ILE104C, ILE137B, ILE146B, ILE165B, ILE177B, ILE23C, ILE42B, ILE42C, ILE45C, ILE53C, LEU105C, LEU111C, LEU11C, LEU136B, LEU138B, LEU142B, LEU144B, LEU163B, LEU163C, LEU167B, LEU167C, LEU171B, LEU174B, LEU19C, LEU220B, LEU224B, LEU225B, LEU22C, LEU29C, LEU33C, LEU39C, LEU43B, LEU43C, LEU47B, LEU47C, LEU51C, LEU56C, LEU60C, LYS12C, LYS34C, MET132B, MET184B, PHE140B, PHE147B, PHE15C, PHE179B, PHE226B, PHE24C, PHE26C, PHE27C, PHE49C, PRO110C, PRO157B, PRO157C, PRO161B, PRO161C, PRO227B, PRO36C, PRO40B, PRO40C, PRO62C, SER149B, SER149C, SER152C, SER156B, SER160B, SER160C, SER164B, SER164C, SER168B, SER31C, SER37C, SER64C, THR126B, THR127B, THR139B, THR150B, THR150C, THR155B, THR170B, THR41B, THR41C, THR55C, TRP35C, TYR106C, TYR178B, TYR221B, TYR223B, VAL108C, VAL133B, VAL134B, VAL158B, VAL158C, VAL169B, VAL175B, VAL25C, VAL63C, VAL8C
• B-D: ALA109B, ALA113B, ALA131D, ALA13B, ALA143D, ALA148D, ALA162B, ALA162D, ALA16B, ALA20B, ALA217D, ALA32B, ALA38B, ALA46B, ALA46D, ALA48B, ALA52B, ALA57B, ALA59B, ALA9B, ARG114B, ARG154D, ASN112B, ASN123D, ASN124D, ASN125D, ASP151B, ASP151D, CYS145D, CYS182D, GLN130D, GLN141D, GLN44B, GLN44D, GLN58B, GLU135D, GLY101B, GLY107B, GLY129D, GLY159B, GLY159D, GLY166B, GLY166D, GLY172D, GLY176D, GLY28B, GLY30B, GLY50B, GLY50D, GLY54B, GLY61B, GLY65B, HIS173D, ILE104B, ILE137D, ILE146D, ILE165D, ILE177D, ILE23B, ILE42B, ILE42D, ILE45B, ILE53B, LEU105B, LEU111B, LEU11B, LEU122D, LEU136D, LEU138D, LEU142D, LEU144D, LEU163B, LEU163D, LEU167B, LEU167D, LEU171D, LEU174D, LEU19B, LEU220D, LEU224D, LEU225D, LEU22B, LEU29B, LEU33B, LEU39B, LEU43B, LEU43D, LEU47B, LEU47D, LEU51B, LEU56B, LEU60B, LYS12B, LYS34B, MET132D, MET184D, PHE140D, PHE147D, PHE15B, PHE179D, PHE226D, PHE24B, PHE26B, PHE27B, PHE49B, PRO110B, PRO157D, PRO161B, PRO161D, PRO227D, PRO36B, PRO40B, PRO40D, PRO62B, SER149B, SER149D, SER152B, SER156D, SER160B, SER160D, SER164B, SER164D, SER168D, SER31B, SER37B, SER64B, THR126D, THR127D, THR139D, THR150B, THR150D, THR155D, THR170D, THR41B, THR41D, THR55B, TRP35B, TYR106B, TYR178D, TYR221D, TYR223D, VAL108B, VAL133D, VAL134D, VAL158B, VAL158D, VAL169D, VAL175D, VAL25B, VAL63B, VAL8B
• C-D: GLN44C, GLN44D, GLY159C, GLY159D, LEU163C, LEU163D, LEU167C, LEU167D, LEU43C, LEU43D, LEU47C, LEU47D, SER160C, SER160D