3D8A

co-crystal structure of tram-trad complex.

• Total interactions analyzed: 120
• Total true interactions: 40
• Strongest Interaction:
  • Chains: B-T
  • Int. Res.: 33
  • Norm. En. per Res.: -4.0147
• Hub Node: B(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-2.3984	-35.5243	-93.2302	-131.1529	61	1	3	4047	2	14	12
A-C	-14.9777	23.8799	-299.202	-290.2998	90	6	13	13131	1	21	17
A-D	-16.3355	30.7928	-309.865	-295.4078	89	8	10	12978	0	21	16
A-S	-13.9234	0.0	-14.1306	-28.054	10	1	0	432	0	2	1
A-U	0.0	-3.1599	-18.5834	-21.7432	17	0	0	823	1	7	8
A-V	0.0	-6.8658	-106.355	-113.2208	31	4	5	3930	0	6	7
B-C	-12.1506	24.2503	-306.294	-294.1942	91	5	11	13083	1	22	16
B-D	-12.2575	20.8275	-321.648	-313.0779	90	3	12	13236	1	21	16
B-G	0.0	-5.7017	-0.5383	-6.24	10	0	0	65	0	8	11
B-H	0.0	0.0	-0.0048	-0.0048	2	0	0	8	0	0	0
B-S	-12.1272	0.4316	-19.4655	-31.161	17	1	0	833	0	7	8
B-T	-8.0583	-10.5294	-113.897	-132.4847	33	2	4	3971	0	6	7
B-U	-8.9416	0.0	-14.0638	-23.0054	11	1	0	412	0	2	1
C-D	0.0	-33.6698	-106.689	-140.3588	64	3	5	4543	2	14	12
C-T	-18.9855	-8.9564	-24.0261	-51.9681	16	2	0	906	1	6	8
C-U	0.0	-6.8291	-103.466	-110.2951	31	4	4	3929	0	6	6
C-V	-13.0748	-2.2467	-14.8095	-30.131	11	2	0	437	0	2	1
D-S	-4.1862	-6.354	-111.818	-122.3582	33	2	5	4114	0	7	11
D-T	-13.0594	-2.3398	-13.0782	-28.4774	10	2	0	418	0	2	1
D-V	-8.5494	-8.617	-21.7507	-38.9171	18	1	0	882	1	7	8
E-F	-3.4548	-42.8327	-103.954	-150.2415	60	2	4	4316	2	14	12
E-G	-16.977	33.92	-300.975	-284.032	90	4	12	12945	0	20	16
E-H	-22.8372	27.8898	-295.057	-290.0044	91	6	11	12875	1	21	17
E-W	-15.4731	-2.0773	-16.4715	-34.0219	12	1	0	448	0	2	1
E-X	-4.0506	-8.861	-107.62	-120.5316	32	3	4	3948	0	6	7
E-Z	-3.8968	-5.6885	-20.951	-30.5363	16	0	0	888	1	7	8
F-G	-20.6535	24.311	-306.219	-302.5615	90	8	11	12974	1	20	16
F-H	-10.1752	35.6401	-302.978	-277.5131	92	4	13	12888	0	21	16
F-W	-10.693	0.8707	-20.7038	-30.5261	16	2	0	762	1	7	7
F-Y	-2.5316	-7.808	-107.43	-117.7696	32	3	4	3918	0	6	7
F-Z	-14.7163	0.0	-13.3346	-28.0509	10	1	0	393	0	2	1
G-H	-16.8186	-32.745	-100.342	-149.9055	63	4	4	4452	2	14	12
G-S	0.0	-8.3751	-2.062	-10.4371	7	0	0	133	1	4	8
G-X	-3.5432	0.0	-10.1693	-13.7125	10	3	0	399	0	2	1
G-Y	-6.8586	-10.142	-20.8759	-37.8766	16	0	0	840	1	7	8
G-Z	0.0	-10.3094	-97.7943	-108.1037	30	3	4	3752	0	6	6
H-S	0.0	11.1034	-2.9259	8.1774	8	0	0	145	0	1	4
H-W	-5.9	-6.9504	-108.826	-121.6764	33	3	5	4058	0	7	7
H-X	-7.6803	-10.3709	-21.2092	-39.2604	18	1	0	846	1	6	8
H-Y	-10.0394	0.0	-10.0558	-20.0952	10	1	0	408	0	2	1

Interface residues

• A-B: ALA60A, ALA60B, ARG119A, ARG119B, ASN62A, ASN62B, ASN67A, ASN67B, CYS73A, CYS73B, GLN63A, GLN63B, GLN78B, GLU116A, GLU116B, GLU65A, GLU65B, GLU72A, GLU72B, GLU88A, GLU88B, HIS93A, HIS93B, ILE84A, ILE84B, ILE87A, ILE87B, LEU69A, LEU69B, LEU70A, LEU70B, LYS112A, LYS112B, LYS68A, LYS68B, LYS76A, LYS76B, MET117A, MET117B, PHE120A, PHE120B, PHE121A, PHE121B, PHE61A, PHE61B, PHE66A, PHE66B, PRO122A, PRO122B, SER115A, SER115B, THR64A, THR64B, THR77A, THR77B, VAL113A, VAL113B, VAL74A, VAL74B, VAL81A, VAL81B
• A-C: ALA82A, ALA82C, ARG110A, ARG119A, ASN104A, ASN67A, ASN67C, ASN97A, ASP108A, CYS73A, CYS73C, GLN63A, GLN63C, GLN78A, GLN78C, GLU101A, GLU107A, GLU111A, GLU116A, GLU118A, GLU65C, GLU72A, GLU72C, GLU88A, GLU88C, GLY86A, GLY86C, HIS93A, HIS93C, ILE109A, ILE84A, ILE84C, ILE87A, ILE87C, LEU69A, LEU69C, LEU70A, LEU70C, LEU71A, LEU71C, LEU85A, LEU85C, LEU90A, LEU90C, LYS112A, LYS68A, LYS68C, LYS76A, LYS76C, LYS83A, LYS83C, LYS99A, MET105A, MET117A, PHE100A, PHE120A, PHE121A, PHE61C, PHE66A, PHE66C, PRO122A, PRO92A, PRO92C, SER114A, SER115A, SER79A, SER79C, SER80A, SER80C, SER89A, SER89C, SER91A, SER91C, SER95A, THR64A, THR64C, THR77A, THR77C, TYR102A, TYR102C, VAL106A, VAL113A, VAL74A, VAL74C, VAL75A, VAL75C, VAL81A, VAL81C, VAL94A, VAL94C
• A-D: ALA82A, ALA82D, ARG110D, ARG119D, ASN104D, ASN67A, ASN67D, ASN97D, ASP108D, CYS73A, CYS73D, GLN63A, GLN63D, GLN78A, GLN78D, GLU101D, GLU107D, GLU111D, GLU116D, GLU118D, GLU65A, GLU72A, GLU72D, GLU88A, GLU88D, GLY86A, GLY86D, HIS93A, HIS93D, ILE109D, ILE84A, ILE84D, ILE87A, ILE87D, LEU69A, LEU69D, LEU70A, LEU70D, LEU71A, LEU71D, LEU85A, LEU85D, LEU90A, LEU90D, LYS112D, LYS68A, LYS68D, LYS76A, LYS76D, LYS83A, LYS83D, LYS99D, MET105D, MET117D, PHE100D, PHE120D, PHE121D, PHE61A, PHE66A, PHE66D, PRO122D, PRO92A, PRO92D, SER114D, SER115D, SER79A, SER79D, SER80A, SER80D, SER89A, SER89D, SER91A, SER91D, THR64A, THR64D, THR77A, THR77D, TYR102A, TYR102D, VAL106D, VAL113D, VAL74A, VAL74D, VAL75A, VAL75D, VAL81A, VAL81D, VAL94A, VAL94D
• A-S: ASP716S, GLU72A, ILE84A, LYS76A, LYS83A, PHE717S, SER79A, SER80A, THR77A, VAL81A
• A-U: ASN97A, ASP108A, ASP715U, ASP716U, GLU111A, GLU712U, GLY714U, ILE109A, LEU85A, LYS112A, LYS99A, MET105A, PHE100A, PHE717U, PRO713U, VAL113A, VAL94A
• A-V: ALA103A, ALA82A, ARG110A, ASN104A, ASP715V, ASP716V, GLN78A, GLU101A, GLU107A, GLU712V, GLU88A, GLY714V, GLY86A, ILE109A, ILE84A, ILE87A, LEU85A, LEU90A, LYS83A, MET105A, PHE717V, PRO713V, SER79A, SER80A, SER89A, TYR102A, VAL106A, VAL113A, VAL711V, VAL75A, VAL81A
• B-C: ALA82B, ALA82C, ARG110C, ARG119C, ASN104C, ASN67B, ASN67C, ASN97C, ASP108C, CYS73B, CYS73C, GLN63B, GLN63C, GLN78B, GLN78C, GLU101C, GLU107C, GLU111C, GLU116C, GLU118C, GLU65B, GLU72B, GLU72C, GLU88B, GLU88C, GLY86B, GLY86C, HIS93B, HIS93C, ILE109C, ILE84B, ILE84C, ILE87B, ILE87C, LEU69B, LEU69C, LEU70B, LEU70C, LEU71B, LEU71C, LEU85B, LEU85C, LEU90B, LEU90C, LYS112C, LYS68B, LYS68C, LYS76B, LYS76C, LYS83B, LYS83C, LYS99C, MET105C, MET117C, PHE100C, PHE120C, PHE121C, PHE61B, PHE66B, PHE66C, PRO122C, PRO92B, PRO92C, SER114C, SER115C, SER79B, SER79C, SER80B, SER80C, SER89B, SER89C, SER91B, SER91C, SER95B, SER95C, THR64B, THR64C, THR77B, THR77C, TYR102B, TYR102C, VAL106C, VAL113C, VAL74B, VAL74C, VAL75B, VAL75C, VAL81B, VAL81C, VAL94B, VAL94C
• B-D: ALA82B, ALA82D, ARG110B, ARG119B, ASN104B, ASN67B, ASN67D, ASN97B, ASP108B, CYS73B, CYS73D, GLN63B, GLN63D, GLN78B, GLN78D, GLU101B, GLU107B, GLU111B, GLU116B, GLU118B, GLU65D, GLU72B, GLU72D, GLU88B, GLU88D, GLY86B, GLY86D, HIS93B, HIS93D, ILE109B, ILE84B, ILE84D, ILE87B, ILE87D, LEU69B, LEU69D, LEU70B, LEU70D, LEU71B, LEU71D, LEU85B, LEU85D, LEU90B, LEU90D, LYS112B, LYS68B, LYS68D, LYS76B, LYS76D, LYS83B, LYS83D, LYS99B, MET105B, MET117B, PHE100B, PHE120B, PHE121B, PHE61D, PHE66B, PHE66D, PRO122B, PRO92B, PRO92D, SER114B, SER115B, SER79B, SER79D, SER80B, SER80D, SER89B, SER89D, SER91B, SER91D, SER95D, THR64B, THR64D, THR77B, THR77D, TYR102B, TYR102D, VAL106B, VAL113B, VAL74B, VAL74D, VAL75B, VAL75D, VAL81B, VAL81D, VAL94B, VAL94D
• B-G: ARG119B, ASP108B, GLU107G, GLU111B, GLU111G, GLU118B, GLU118G, LYS99B, PRO122G, SER115B
• B-H: ALA60H, LYS99B
• B-S: ASN97B, ASP108B, ASP715S, ASP716S, GLU111B, GLU712S, GLY714S, ILE109B, LEU85B, LYS112B, LYS99B, MET105B, PHE100B, PHE717S, PRO713S, VAL711S, VAL94B
• B-T: ALA103B, ALA82B, ARG110B, ASN104B, ASP108B, ASP715T, ASP716T, GLN78B, GLU101B, GLU107B, GLU712T, GLU88B, GLY714T, GLY86B, ILE109B, ILE84B, ILE87B, LEU85B, LEU90B, LYS83B, MET105B, PHE100B, PHE717T, PRO713T, SER79B, SER80B, SER89B, TYR102B, VAL106B, VAL113B, VAL711T, VAL75B, VAL81B
• B-U: ASP716U, CYS73B, GLU72B, ILE84B, LYS76B, LYS83B, PHE717U, SER79B, SER80B, THR77B, VAL81B
• C-D: ALA60C, ALA60D, ARG119C, ARG119D, ASN62C, ASN62D, ASN67C, ASN67D, CYS73C, CYS73D, GLN63C, GLN63D, GLN78C, GLN78D, GLU116C, GLU116D, GLU118C, GLU118D, GLU65C, GLU65D, GLU72C, GLU72D, GLU88C, GLU88D, HIS93C, HIS93D, ILE84C, ILE84D, ILE87C, ILE87D, LEU69C, LEU69D, LEU70C, LEU70D, LYS112C, LYS112D, LYS68C, LYS68D, LYS76C, LYS76D, MET117C, MET117D, PHE120C, PHE120D, PHE121C, PHE121D, PHE61C, PHE61D, PHE66C, PHE66D, PRO122C, PRO122D, SER115C, SER115D, THR64C, THR64D, THR77C, THR77D, VAL113C, VAL113D, VAL74C, VAL74D, VAL81C, VAL81D
• C-T: ASN97C, ASP108C, ASP715T, ASP716T, GLU712T, GLY714T, ILE109C, LEU85C, LYS112C, LYS99C, MET105C, PHE100C, PHE717T, PRO713T, VAL711T, VAL94C
• C-U: ALA103C, ALA82C, ARG110C, ASN104C, ASP715U, ASP716U, GLN78C, GLU101C, GLU107C, GLU712U, GLU88C, GLY714U, GLY86C, ILE109C, ILE84C, ILE87C, LEU85C, LEU90C, LYS83C, MET105C, PHE717U, PRO713U, SER79C, SER80C, SER89C, TYR102C, VAL106C, VAL113C, VAL711U, VAL75C, VAL81C
• C-V: ASP716V, CYS73C, GLU72C, ILE84C, LYS76C, LYS83C, PHE717V, SER79C, SER80C, THR77C, VAL81C
• D-S: ALA103D, ALA82D, ARG110D, ASN104D, ASP710S, ASP715S, ASP716S, GLN78D, GLU101D, GLU107D, GLU712S, GLU88D, GLY714S, GLY86D, ILE109D, ILE84D, ILE87D, LEU85D, LEU90D, LYS83D, MET105D, PHE100D, PHE717S, PRO713S, SER79D, SER80D, SER89D, TYR102D, VAL106D, VAL113D, VAL711S, VAL75D, VAL81D
• D-T: ASP716T, GLU72D, ILE84D, LYS76D, LYS83D, PHE717T, SER79D, SER80D, THR77D, VAL81D
• D-V: ASN97D, ASP108D, ASP715V, ASP716V, GLU111D, GLU116D, GLU712V, GLY714V, ILE109D, LYS112D, LYS99D, MET105D, PHE100D, PHE717V, PRO713V, VAL113D, VAL711V, VAL94D
• E-F: ALA60E, ALA60F, ARG119E, ARG119F, ASN62E, ASN62F, ASN67E, ASN67F, CYS73E, CYS73F, GLN63E, GLN63F, GLN78E, GLU116E, GLU116F, GLU65E, GLU65F, GLU72E, GLU72F, GLU88E, GLU88F, HIS93E, ILE84E, ILE84F, ILE87E, ILE87F, LEU69E, LEU69F, LEU70E, LEU70F, LYS112E, LYS112F, LYS68E, LYS68F, LYS76E, LYS76F, MET117E, MET117F, PHE120E, PHE120F, PHE121E, PHE121F, PHE61E, PHE61F, PHE66E, PHE66F, PRO122E, PRO122F, SER115E, SER115F, THR64E, THR64F, THR77E, THR77F, VAL113E, VAL113F, VAL74E, VAL74F, VAL81E, VAL81F
• E-G: ALA82E, ALA82G, ARG110E, ARG119E, ASN104E, ASN67E, ASN67G, ASN97E, ASP108E, CYS73E, CYS73G, GLN63E, GLN63G, GLN78E, GLN78G, GLU101E, GLU107E, GLU111E, GLU116E, GLU118E, GLU65G, GLU72E, GLU72G, GLU88E, GLU88G, GLY86E, GLY86G, HIS93E, HIS93G, ILE109E, ILE84E, ILE84G, ILE87E, ILE87G, LEU69E, LEU69G, LEU70E, LEU70G, LEU71E, LEU71G, LEU85E, LEU85G, LEU90E, LEU90G, LYS112E, LYS68E, LYS68G, LYS76E, LYS76G, LYS83E, LYS83G, LYS99E, MET105E, MET117E, PHE100E, PHE120E, PHE121E, PHE61G, PHE66E, PHE66G, PRO122E, PRO92E, PRO92G, SER114E, SER115E, SER79E, SER79G, SER80E, SER80G, SER89E, SER89G, SER91E, SER91G, SER95E, THR64E, THR64G, THR77E, THR77G, TYR102E, TYR102G, VAL106E, VAL113E, VAL74E, VAL74G, VAL75E, VAL75G, VAL81E, VAL81G, VAL94E, VAL94G
• E-H: ALA82E, ALA82H, ARG110H, ARG119H, ASN104H, ASN67E, ASN67H, ASN97H, ASP108H, CYS73E, CYS73H, GLN63E, GLN63H, GLN78E, GLN78H, GLU101H, GLU107H, GLU111H, GLU116H, GLU118H, GLU65E, GLU72E, GLU72H, GLU88E, GLU88H, GLY86E, GLY86H, HIS93E, HIS93H, ILE109H, ILE84E, ILE84H, ILE87E, ILE87H, LEU69E, LEU69H, LEU70E, LEU70H, LEU71E, LEU71H, LEU85E, LEU85H, LEU90E, LEU90H, LYS112H, LYS68E, LYS68H, LYS76E, LYS76H, LYS83E, LYS83H, LYS99H, MET105H, MET117H, PHE100H, PHE120H, PHE121H, PHE61E, PHE66E, PHE66H, PRO122H, PRO92E, PRO92H, SER114H, SER115H, SER79E, SER79H, SER80E, SER80H, SER89E, SER89H, SER91E, SER91H, SER95E, SER95H, THR64E, THR64H, THR77E, THR77H, TYR102E, TYR102H, VAL106H, VAL113H, VAL74E, VAL74H, VAL75E, VAL75H, VAL81E, VAL81H, VAL94E, VAL94H
• E-W: ASP716W, CYS73E, GLU72E, ILE84E, LYS76E, LYS83E, PHE717W, SER79E, SER80E, THR77E, VAL75E, VAL81E
• E-X: ALA103E, ALA82E, ARG110E, ASN104E, ASP715X, ASP716X, GLN78E, GLU101E, GLU107E, GLU712X, GLU88E, GLY714X, GLY86E, ILE109E, ILE84E, ILE87E, LEU85E, LEU90E, LYS83E, MET105E, PHE100E, PHE717X, PRO713X, SER79E, SER80E, SER89E, TYR102E, VAL106E, VAL113E, VAL711X, VAL75E, VAL81E
• E-Z: ASN97E, ASP108E, ASP715Z, ASP716Z, GLU111E, GLU712Z, GLY714Z, ILE109E, LYS112E, LYS99E, MET105E, PHE100E, PHE717Z, PRO713Z, VAL711Z, VAL94E
• F-G: ALA82F, ALA82G, ARG110G, ARG119G, ASN104G, ASN62F, ASN67F, ASN67G, ASN97G, ASP108G, CYS73F, CYS73G, GLN63F, GLN63G, GLN78F, GLN78G, GLU101G, GLU107G, GLU111G, GLU116G, GLU118G, GLU65F, GLU72F, GLU72G, GLU88F, GLU88G, GLY86F, GLY86G, HIS93F, HIS93G, ILE109G, ILE84F, ILE84G, ILE87F, ILE87G, LEU69F, LEU69G, LEU70F, LEU70G, LEU71F, LEU71G, LEU85F, LEU85G, LEU90F, LEU90G, LYS112G, LYS68F, LYS68G, LYS76F, LYS76G, LYS83F, LYS83G, LYS99G, MET105G, MET117G, PHE100G, PHE120G, PHE121G, PHE61F, PHE66F, PHE66G, PRO122G, PRO92F, PRO92G, SER114G, SER115G, SER79F, SER79G, SER80F, SER80G, SER89F, SER89G, SER91F, SER91G, SER95G, THR64F, THR64G, THR77F, THR77G, TYR102F, TYR102G, VAL106G, VAL113G, VAL74F, VAL74G, VAL75F, VAL75G, VAL81F, VAL81G, VAL94G
• F-H: ALA82F, ALA82H, ARG110F, ARG119F, ASN104F, ASN62H, ASN67F, ASN67H, ASN97F, ASP108F, CYS73F, CYS73H, GLN63F, GLN63H, GLN78F, GLN78H, GLU101F, GLU107F, GLU111F, GLU116F, GLU118F, GLU65H, GLU72F, GLU72H, GLU88F, GLU88H, GLY86F, GLY86H, HIS93F, HIS93H, ILE109F, ILE84F, ILE84H, ILE87F, ILE87H, LEU69F, LEU69H, LEU70F, LEU70H, LEU71F, LEU71H, LEU85F, LEU85H, LEU90F, LEU90H, LYS112F, LYS68F, LYS68H, LYS76F, LYS76H, LYS83F, LYS83H, LYS99F, MET105F, MET117F, PHE100F, PHE120F, PHE121F, PHE61H, PHE66F, PHE66H, PRO122F, PRO92F, PRO92H, SER114F, SER115F, SER79F, SER79H, SER80F, SER80H, SER89F, SER89H, SER91F, SER91H, SER95F, SER95H, THR64F, THR64H, THR77F, THR77H, TYR102F, TYR102H, VAL106F, VAL113F, VAL74F, VAL74H, VAL75F, VAL75H, VAL81F, VAL81H, VAL94F, VAL94H
• F-W: ASN97F, ASP108F, ASP715W, ASP716W, GLU116F, GLU712W, GLY714W, ILE109F, LYS112F, LYS99F, MET105F, PHE100F, PHE717W, PRO713W, VAL711W, VAL94F
• F-Y: ALA103F, ALA82F, ARG110F, ASN104F, ASP715Y, ASP716Y, GLN78F, GLU101F, GLU107F, GLU712Y, GLU88F, GLY714Y, GLY86F, ILE109F, ILE84F, ILE87F, LEU85F, LEU90F, LYS83F, MET105F, PHE100F, PHE717Y, PRO713Y, SER79F, SER80F, SER89F, TYR102F, VAL106F, VAL113F, VAL711Y, VAL75F, VAL81F
• F-Z: ASP716Z, GLU72F, ILE84F, LYS76F, LYS83F, PHE717Z, SER79F, SER80F, THR77F, VAL81F
• G-H: ALA60G, ALA60H, ARG119G, ARG119H, ASN62G, ASN62H, ASN67G, ASN67H, CYS73G, CYS73H, GLN63G, GLN63H, GLN78G, GLN78H, GLU116G, GLU116H, GLU65G, GLU65H, GLU72G, GLU72H, GLU88G, GLU88H, HIS93G, HIS93H, ILE84G, ILE84H, ILE87G, ILE87H, LEU69G, LEU69H, LEU70G, LEU70H, LYS112G, LYS112H, LYS68G, LYS68H, LYS76G, LYS76H, MET117G, MET117H, PHE120G, PHE120H, PHE121G, PHE121H, PHE61G, PHE61H, PHE66G, PHE66H, PRO122G, PRO122H, SER115G, SER115H, SER91H, THR64G, THR64H, THR77G, THR77H, VAL113G, VAL113H, VAL74G, VAL74H, VAL81G, VAL81H
• G-S: ARG119G, ASP710S, ASP715S, ASP716S, GLU118G, PHE120G, VAL711S
• G-X: ASP716X, GLU72G, ILE84G, LYS76G, LYS83G, PHE717X, SER79G, SER80G, THR77G, VAL81G
• G-Y: ASN97G, ASP108G, ASP715Y, ASP716Y, GLU111G, GLU712Y, GLY714Y, ILE109G, LYS112G, LYS99G, MET105G, PHE100G, PHE717Y, PRO713Y, VAL711Y, VAL94G
• G-Z: ALA103G, ALA82G, ARG110G, ASP715Z, ASP716Z, GLN78G, GLU101G, GLU107G, GLU712Z, GLU88G, GLY714Z, GLY86G, ILE109G, ILE84G, ILE87G, LEU85G, LEU90G, LYS83G, MET105G, PHE717Z, PRO713Z, SER79G, SER80G, SER89G, TYR102G, VAL106G, VAL113G, VAL711Z, VAL75G, VAL81G
• H-S: ALA60H, ASN62H, ASP710S, ASP715S, GLU65H, GLU712S, LYS68H, PHE61H
• H-W: ALA103H, ALA82H, ARG110H, ASN104H, ASP108H, ASP715W, ASP716W, GLN78H, GLU101H, GLU107H, GLU712W, GLU88H, GLY714W, GLY86H, ILE109H, ILE84H, ILE87H, LEU85H, LEU90H, LYS83H, MET105H, PHE100H, PHE717W, PRO713W, SER79H, SER80H, SER89H, TYR102H, VAL106H, VAL113H, VAL711W, VAL75H, VAL81H
• H-X: ASN97H, ASP108H, ASP715X, ASP716X, GLU712X, GLY714X, HIS93H, ILE109H, LEU85H, LYS112H, LYS99H, MET105H, PHE100H, PHE717X, PRO713X, VAL113H, VAL711X, VAL94H
• H-Y: ASP716Y, GLU72H, ILE84H, LYS76H, LYS83H, PHE717Y, SER79H, SER80H, THR77H, VAL81H