3D47

crystal structure of l-rhamnonate dehydratase from salmonella typhimurium complexed with mg and d-malate

• Total interactions analyzed: 28
• Total true interactions: 19
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 204
  • Norm. En. per Res.: -3.87
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-83.1215	-38.4789	-652.119	-773.7194	208	23	11	24165	6	43	45
A-C	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	1
A-E	-67.4151	5.4631	-515.753	-577.7049	189	26	12	21898	5	36	55
A-F	-13.926	-32.5184	-60.7681	-107.2126	73	1	0	3373	4	31	30
A-G	-15.5357	-33.9045	-62.9654	-112.4056	74	1	0	3464	4	30	31
B-E	-4.4044	-19.6783	-57.8988	-81.9815	74	0	0	3376	3	30	30
B-G	-76.9954	-10.508	-516.15	-603.6534	186	25	12	21770	3	38	54
B-H	-3.7403	-31.538	-53.3981	-88.6765	75	0	0	3172	3	30	30
C-D	-98.5905	-37.6188	-653.261	-789.4703	204	27	11	24250	6	42	45
C-F	-11.8182	-15.8789	-66.6329	-94.33	75	1	0	3558	4	31	31
C-G	-13.5257	-30.8564	-73.9222	-118.3043	77	0	0	3947	4	31	31
C-H	-59.4435	10.4421	-517.303	-566.3044	189	30	14	22158	3	38	55
D-E	-2.1368	-26.165	-55.3986	-83.7004	72	0	0	3163	4	31	30
D-F	-65.852	14.0528	-500.831	-552.6302	189	24	12	21700	2	34	53
D-H	-9.3455	-22.454	-53.3619	-85.1614	71	0	0	3171	3	31	30
E-F	-77.4822	-38.9694	-652.162	-768.6136	204	20	11	23951	6	41	45
E-H	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
F-G	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
G-H	-99.3133	-41.6955	-656.427	-797.4358	207	30	11	24362	6	43	45

Interface residues

• A-B: ALA122A, ALA122B, ALA21A, ALA21B, ALA23A, ALA23B, ALA88A, ALA88B, ARG102A, ARG102B, ARG264A, ARG264B, ARG289A, ARG289B, ARG53A, ARG53B, ARG59A, ARG59B, ASN101A, ASN101B, ASN135A, ASN135B, ASN65A, ASN65B, ASP117A, ASP117B, ASP31A, ASP31B, ASP34A, ASP54A, ASP54B, CYS93A, CYS93B, GLN118A, GLN118B, GLN258A, GLN258B, GLN259A, GLN259B, GLN286A, GLN286B, GLN60A, GLN60B, GLU253A, GLU253B, GLU261A, GLU261B, GLU265A, GLU265B, GLU280A, GLU280B, GLU293A, GLU293B, GLU90A, GLU90B, GLU97A, GLU97B, GLY121A, GLY121B, GLY128A, GLY128B, GLY130A, GLY130B, GLY131A, GLY131B, GLY19A, GLY19B, GLY20A, GLY20B, GLY262A, GLY262B, GLY283A, GLY283B, GLY63A, GLY63B, GLY68A, GLY68B, GLY89A, GLY89B, GLY92A, GLY92B, HIS116A, HIS116B, HIS281A, HIS281B, HIS282A, HIS282B, HIS33A, HIS33B, HIS405A, HIS405B, HIS99A, HIS99B, ILE104A, ILE104B, ILE115A, ILE115B, ILE64A, ILE64B, ILE95A, ILE95B, LEU100A, LEU100B, LEU114A, LEU114B, LEU120A, LEU120B, LEU132A, LEU132B, LEU255A, LEU255B, LEU285A, LEU285B, LEU291A, LEU291B, LEU67A, LEU67B, LYS107A, LYS107B, LYS113A, LYS113B, LYS51A, LYS51B, LYS98A, LYS98B, MET119A, MET119B, MET124A, MET124B, MET134A, MET134B, MET229A, MET229B, MET49A, MET49B, MET91A, MET91B, PHE103A, PHE103B, PHE17A, PHE17B, PHE288A, PHE288B, PHE62A, PHE62B, PHE94A, PHE94B, PRO256A, PRO256B, PRO257A, PRO257B, PRO402A, PRO402B, PRO48A, PRO48B, SER127A, SER127B, SER129A, SER129B, SER230A, SER230B, SER287A, SER287B, SER404A, SER404B, SER50A, SER50B, SER58B, SER61A, SER61B, THR123A, THR123B, THR136A, THR136B, THR22A, THR22B, THR284A, THR284B, THR290A, THR290B, THR47A, THR47B, THR87A, THR87B, TRP228A, TRP228B, TRP305A, TRP305B, TYR125A, TYR125B, TYR126A, TYR126B, TYR260A, TYR260B, TYR263A, TYR263B, TYR403A, TYR403B, TYR52A, TYR52B, TYR55A, TYR55B, VAL133A, VAL133B, VAL66A, VAL66B, VAL96A, VAL96B
• A-C: ARG268A, ARG268C
• A-E: ALA163A, ALA163E, ALA292A, ALA292E, ALA316A, ALA316E, ALA317A, ALA317E, ALA319A, ALA319E, ALA338A, ALA338E, ARG165A, ARG165E, ARG289A, ARG289E, ARG322A, ARG322E, ASN344A, ASN344E, ASN3A, ASN3E, ASN78A, ASN78E, ASP111A, ASP111E, ASP117A, ASP117E, ASP146A, ASP146E, ASP166A, ASP166E, ASP370A, ASP370E, ASP385A, ASP385E, CYS108A, CYS108E, GLN118A, GLN118E, GLN286A, GLN286E, GLN324A, GLN324E, GLN80A, GLN80E, GLU293A, GLU293E, GLU2A, GLU2E, GLU314A, GLU314E, GLU392A, GLU392E, GLY149A, GLY149E, GLY153A, GLY153E, GLY161A, GLY161E, GLY162A, GLY162E, GLY295A, GLY295E, GLY323A, GLY323E, GLY388A, GLY388E, GLY390A, GLY390E, GLY82E, HIS116A, HIS116E, HIS337A, HIS337E, ILE112A, ILE112E, ILE115A, ILE115E, ILE315A, ILE315E, ILE340A, ILE340E, ILE4A, ILE4E, LEU114A, LEU114E, LEU120A, LEU120E, LEU154A, LEU154E, LEU159A, LEU159E, LEU160A, LEU160E, LEU285A, LEU285E, LEU309A, LEU309E, LEU318A, LEU318E, LEU369A, LEU369E, LEU384A, LEU384E, LEU393A, LEU393E, LEU7A, LEU7E, LYS107A, LYS107E, LYS113A, LYS113E, LYS150A, LYS150E, LYS158A, LYS158E, LYS320A, LYS320E, LYS381A, LYS381E, LYS386A, LYS386E, LYS9A, LYS9E, MET1A, MET1E, MET299A, MET299E, MET5A, MET5E, PHE148A, PHE148E, PHE288A, PHE288E, PHE342A, PHE342E, PHE389A, PHE389E, PHE83A, PHE83E, PRO155A, PRO155E, PRO387A, PRO387E, SER110A, SER110E, SER287A, SER287E, SER321A, SER321E, SER382A, SER382E, THR284A, THR284E, THR290A, THR290E, THR310A, THR310E, THR311A, THR311E, THR341A, THR341E, THR343A, THR343E, THR6A, THR6E, THR81A, THR81E, TRP145A, TRP145E, TYR157A, TYR157E, VAL109A, VAL109E, VAL151A, VAL151E, VAL152A, VAL152E, VAL156A, VAL156E, VAL164A, VAL164E, VAL313A, VAL313E, VAL339A, VAL339E, VAL391A, VAL391E
• A-F: ALA163A, ALA201F, ALA236F, ALA240F, ALA270F, ALA272A, ARG165A, ARG204F, ARG214A, ARG268A, ARG268F, ARG322A, ARG53F, ASN234F, ASN247A, ASN269F, ASN344A, ASP166A, ASP198F, ASP200F, ASP220A, ASP232F, ASP297A, GLN169A, GLN231F, GLN259F, GLN324A, GLU261F, GLU265F, GLY199F, GLY202F, GLY218A, GLY262F, GLY273A, GLY295A, GLY323A, HIS197F, HIS241F, ILE203F, ILE296A, ILE298A, LEU223A, LEU239F, LEU248A, LEU255F, LEU325A, LYS238F, LYS249A, LYS267A, LYS320A, LYS51F, MET274A, MET275A, PHE221A, PHE342A, PHE347A, PRO196F, PRO219A, PRO256F, PRO271A, PRO271F, PRO346A, SER321A, THR237F, THR343A, THR345A, TRP222A, TRP250A, TYR235F, TYR52F, VAL164A, VAL233F, VAL276A
• A-G: ALA163G, ALA201A, ALA236A, ALA240A, ALA270A, ALA272G, ARG165G, ARG204A, ARG214G, ARG268A, ARG268G, ARG322G, ARG53A, ASN234A, ASN247G, ASN269A, ASN344G, ASP166G, ASP198A, ASP200A, ASP220G, ASP232A, ASP297G, GLN169G, GLN231A, GLN259A, GLN324G, GLU261A, GLU265A, GLY199A, GLY202A, GLY218G, GLY262A, GLY273G, GLY295G, GLY323G, HIS197A, HIS241A, ILE203A, ILE296G, ILE298G, LEU223G, LEU239A, LEU248G, LEU255A, LEU325G, LYS205A, LYS238A, LYS249G, LYS267G, LYS320G, LYS51A, MET274G, MET275G, PHE221G, PHE342G, PHE347G, PRO196A, PRO219G, PRO256A, PRO271A, PRO271G, PRO346G, SER321G, THR237A, THR343G, THR345G, TRP222G, TRP250G, TYR235A, TYR52A, VAL164G, VAL233A, VAL276G
• B-E: ALA163E, ALA201B, ALA236B, ALA240B, ALA270B, ALA270E, ALA272E, ARG165E, ARG204B, ARG214E, ARG264E, ARG268B, ARG268E, ARG322E, ARG53B, ASN234B, ASN247E, ASN269B, ASN269E, ASN344E, ASP166E, ASP198B, ASP200B, ASP220E, ASP232B, ASP297E, GLN169E, GLN259B, GLN324E, GLU261B, GLU265B, GLY199B, GLY202B, GLY262B, GLY273E, GLY295E, GLY323E, HIS197B, HIS241B, ILE203B, ILE296E, ILE298E, LEU223E, LEU239B, LEU248E, LEU255B, LEU325E, LYS238B, LYS249E, LYS267E, LYS320E, LYS51B, MET274E, MET275E, PHE221E, PHE342E, PHE347E, PRO196B, PRO219E, PRO256B, PRO271B, PRO271E, PRO346E, SER321E, THR237B, THR343E, THR345E, TRP222E, TRP250E, TYR235B, TYR52B, VAL164E, VAL233B, VAL276E
• B-G: ALA163B, ALA163G, ALA292B, ALA292G, ALA316B, ALA316G, ALA317B, ALA317G, ALA319B, ALA319G, ALA338B, ALA338G, ARG165B, ARG165G, ARG289B, ARG289G, ARG322B, ARG322G, ASN344B, ASN344G, ASN3B, ASN3G, ASP111B, ASP111G, ASP117B, ASP117G, ASP146B, ASP146G, ASP166B, ASP166G, ASP370B, ASP370G, ASP385B, ASP385G, CYS108B, CYS108G, GLN118B, GLN118G, GLN286B, GLN286G, GLN324B, GLN324G, GLN80B, GLN80G, GLU293B, GLU293G, GLU2B, GLU2G, GLU314B, GLU314G, GLU392B, GLU392G, GLY149B, GLY149G, GLY153B, GLY153G, GLY161B, GLY161G, GLY162B, GLY162G, GLY295B, GLY295G, GLY323B, GLY323G, GLY388B, GLY388G, GLY390B, GLY390G, GLY82G, HIS116B, HIS116G, HIS337B, HIS337G, ILE112B, ILE112G, ILE115B, ILE115G, ILE315B, ILE315G, ILE340B, ILE340G, ILE4B, ILE4G, LEU114B, LEU114G, LEU120B, LEU120G, LEU154B, LEU154G, LEU159B, LEU159G, LEU160B, LEU160G, LEU285B, LEU285G, LEU309B, LEU309G, LEU318B, LEU318G, LEU369B, LEU369G, LEU384B, LEU384G, LEU393G, LEU7B, LEU7G, LYS107B, LYS107G, LYS113B, LYS113G, LYS150B, LYS150G, LYS158B, LYS158G, LYS320B, LYS320G, LYS381B, LYS381G, LYS386B, LYS386G, LYS9B, LYS9G, MET1B, MET1G, MET299B, MET299G, MET5B, MET5G, PHE148B, PHE148G, PHE288B, PHE288G, PHE342B, PHE342G, PHE389B, PHE389G, PHE83B, PHE83G, PRO155B, PRO155G, PRO387B, PRO387G, PRO8G, SER110B, SER110G, SER287B, SER287G, SER321B, SER321G, SER382B, SER382G, THR284B, THR284G, THR290B, THR290G, THR310B, THR310G, THR311B, THR311G, THR341B, THR341G, THR343B, THR343G, THR6B, THR6G, THR81G, TRP145B, TRP145G, TYR157B, TYR157G, VAL109B, VAL109G, VAL151B, VAL151G, VAL152B, VAL152G, VAL156B, VAL156G, VAL164B, VAL164G, VAL313B, VAL313G, VAL339B, VAL339G, VAL391B, VAL391G
• B-H: ALA163B, ALA201H, ALA236H, ALA240H, ALA270B, ALA270H, ALA272B, ARG165B, ARG204H, ARG214B, ARG268B, ARG268H, ARG322B, ARG53H, ASN234H, ASN247B, ASN269H, ASN344B, ASP166B, ASP198H, ASP200H, ASP220B, ASP232H, ASP297B, GLN169B, GLN231H, GLN259H, GLN324B, GLU261H, GLU265H, GLY199H, GLY202H, GLY218B, GLY262H, GLY273B, GLY295B, GLY323B, HIS197H, HIS241H, ILE203H, ILE296B, ILE298B, LEU223B, LEU239H, LEU248B, LEU255H, LEU325B, LYS205H, LYS238H, LYS249B, LYS267B, LYS320B, LYS51H, MET274B, MET275B, PHE221B, PHE342B, PHE347B, PRO196H, PRO219B, PRO256H, PRO271B, PRO271H, PRO346B, SER321B, THR237H, THR343B, THR345B, TRP222B, TRP250B, TYR235H, TYR52H, VAL164B, VAL233H, VAL276B
• C-D: ALA122C, ALA122D, ALA21C, ALA21D, ALA23C, ALA23D, ALA88C, ALA88D, ARG102C, ARG102D, ARG264C, ARG264D, ARG289C, ARG289D, ARG53C, ARG53D, ARG59C, ARG59D, ASN101C, ASN101D, ASN135C, ASN135D, ASN65C, ASN65D, ASP117C, ASP117D, ASP31C, ASP31D, ASP54C, ASP54D, CYS93C, CYS93D, GLN118C, GLN118D, GLN258C, GLN258D, GLN259C, GLN259D, GLN286C, GLN286D, GLN60C, GLN60D, GLU253C, GLU253D, GLU261C, GLU261D, GLU265C, GLU265D, GLU280C, GLU280D, GLU293C, GLU293D, GLU90C, GLU90D, GLU97C, GLU97D, GLY121C, GLY121D, GLY128C, GLY128D, GLY130C, GLY130D, GLY131C, GLY131D, GLY19C, GLY19D, GLY20C, GLY20D, GLY262C, GLY262D, GLY283C, GLY283D, GLY63C, GLY63D, GLY68C, GLY68D, GLY89C, GLY89D, GLY92C, GLY92D, HIS116C, HIS116D, HIS281C, HIS281D, HIS282C, HIS282D, HIS33C, HIS33D, HIS99C, HIS99D, ILE104C, ILE104D, ILE115C, ILE115D, ILE64C, ILE64D, ILE95C, ILE95D, LEU100C, LEU100D, LEU114C, LEU114D, LEU120C, LEU120D, LEU132C, LEU132D, LEU255C, LEU255D, LEU285C, LEU285D, LEU291C, LEU291D, LEU67C, LEU67D, LYS107C, LYS107D, LYS113C, LYS113D, LYS51C, LYS51D, LYS98C, LYS98D, MET119C, MET119D, MET124C, MET124D, MET134C, MET134D, MET229C, MET229D, MET49C, MET49D, MET91C, MET91D, PHE103C, PHE103D, PHE17C, PHE17D, PHE288C, PHE288D, PHE62C, PHE62D, PHE94C, PHE94D, PRO256C, PRO256D, PRO257C, PRO257D, PRO402C, PRO402D, PRO48C, PRO48D, SER127C, SER127D, SER129C, SER129D, SER230C, SER230D, SER287C, SER287D, SER404C, SER404D, SER50C, SER50D, SER61C, SER61D, THR123C, THR123D, THR136C, THR136D, THR22C, THR22D, THR284C, THR284D, THR290C, THR290D, THR47C, THR47D, THR87C, THR87D, TRP228C, TRP228D, TRP305C, TRP305D, TYR125C, TYR125D, TYR126C, TYR126D, TYR260C, TYR260D, TYR263C, TYR263D, TYR403C, TYR403D, TYR52C, TYR52D, TYR55C, TYR55D, VAL133C, VAL133D, VAL66C, VAL66D, VAL96C, VAL96D
• C-F: ALA163F, ALA201C, ALA236C, ALA240C, ALA270C, ALA270F, ALA272F, ARG165F, ARG204C, ARG214F, ARG268C, ARG268F, ARG322F, ARG53C, ASN234C, ASN247F, ASN269C, ASN344F, ASP166F, ASP198C, ASP200C, ASP220F, ASP232C, ASP297F, GLN169F, GLN231C, GLN259C, GLN324F, GLU261C, GLU265C, GLY199C, GLY202C, GLY218F, GLY262C, GLY273F, GLY295F, GLY323F, HIS197C, HIS241C, ILE203C, ILE296F, ILE298F, LEU223F, LEU239C, LEU248F, LEU255C, LEU325F, LYS205C, LYS238C, LYS249F, LYS267F, LYS320F, LYS51C, MET274F, MET275F, PHE221F, PHE342F, PHE347F, PRO196C, PRO219F, PRO256C, PRO271C, PRO271F, PRO346F, SER321F, THR237C, THR343F, THR345F, TRP222F, TRP250F, TYR235C, TYR52C, VAL164F, VAL233C, VAL276F
• C-G: ALA163C, ALA201G, ALA236G, ALA240G, ALA270C, ALA270G, ALA272C, ARG165C, ARG204G, ARG214C, ARG264C, ARG268C, ARG268G, ARG322C, ARG53G, ASN234G, ASN247C, ASN269G, ASN344C, ASP166C, ASP198G, ASP200G, ASP220C, ASP232G, ASP297C, GLN169C, GLN231G, GLN258G, GLN259G, GLN324C, GLU261G, GLU265G, GLY199G, GLY202G, GLY218C, GLY262G, GLY273C, GLY295C, GLY323C, HIS197G, HIS241G, ILE203G, ILE296C, ILE298C, LEU223C, LEU239G, LEU248C, LEU255G, LEU325C, LYS205G, LYS238G, LYS249C, LYS267C, LYS320C, LYS51G, MET274C, MET275C, PHE221C, PHE342C, PHE347C, PRO196G, PRO219C, PRO256G, PRO271C, PRO271G, PRO346C, SER321C, THR237G, THR343C, THR345C, TRP222C, TRP250C, TYR235G, TYR52G, VAL164C, VAL233G, VAL276C
• C-H: ALA163C, ALA163H, ALA292C, ALA292H, ALA316C, ALA316H, ALA317C, ALA317H, ALA319C, ALA319H, ALA338C, ALA338H, ARG165C, ARG165H, ARG289C, ARG289H, ARG322C, ARG322H, ASN344C, ASN344H, ASN3C, ASN3H, ASP111C, ASP111H, ASP117C, ASP117H, ASP146C, ASP146H, ASP166C, ASP166H, ASP370C, ASP370H, ASP385C, ASP385H, CYS108C, CYS108H, GLN118C, GLN118H, GLN286C, GLN286H, GLN324C, GLN324H, GLN80C, GLN80H, GLU293C, GLU293H, GLU2C, GLU2H, GLU314C, GLU314H, GLU392C, GLU392H, GLY149C, GLY149H, GLY153C, GLY153H, GLY161C, GLY161H, GLY162C, GLY162H, GLY295C, GLY295H, GLY323C, GLY323H, GLY388C, GLY388H, GLY390C, GLY390H, GLY82C, GLY82H, HIS116C, HIS116H, HIS337C, HIS337H, ILE112C, ILE112H, ILE115C, ILE115H, ILE315C, ILE315H, ILE340C, ILE340H, ILE4C, ILE4H, LEU114C, LEU114H, LEU120C, LEU120H, LEU154C, LEU154H, LEU159C, LEU159H, LEU160C, LEU160H, LEU285C, LEU285H, LEU309C, LEU309H, LEU318C, LEU318H, LEU369C, LEU369H, LEU384C, LEU384H, LEU393C, LEU393H, LEU7C, LEU7H, LYS107C, LYS107H, LYS113C, LYS113H, LYS150C, LYS150H, LYS158C, LYS158H, LYS320C, LYS320H, LYS381C, LYS381H, LYS386C, LYS386H, LYS9C, LYS9H, MET1C, MET1H, MET299C, MET299H, MET5C, MET5H, PHE148C, PHE148H, PHE288C, PHE288H, PHE342C, PHE342H, PHE389C, PHE389H, PHE83C, PHE83H, PRO155C, PRO155H, PRO387C, PRO387H, PRO8C, PRO8H, SER110C, SER110H, SER287C, SER287H, SER321C, SER321H, SER382C, SER382H, THR284C, THR284H, THR290C, THR290H, THR310C, THR310H, THR311C, THR311H, THR341C, THR341H, THR343C, THR343H, THR6C, THR6H, THR81C, THR81H, TRP145C, TRP145H, TYR157C, TYR157H, VAL109C, VAL109H, VAL151C, VAL151H, VAL152C, VAL152H, VAL156C, VAL156H, VAL164C, VAL164H, VAL313C, VAL313H, VAL339H, VAL391C, VAL391H
• D-E: ALA163D, ALA201E, ALA240E, ALA270E, ALA272D, ARG165D, ARG204E, ARG214D, ARG268D, ARG268E, ARG322D, ARG53E, ASN234E, ASN247D, ASN269E, ASN344D, ASP166D, ASP198E, ASP200E, ASP220D, ASP232E, ASP297D, GLN169D, GLN259E, GLN324D, GLU261E, GLU265E, GLY199E, GLY202E, GLY218D, GLY262E, GLY273D, GLY295D, GLY323D, HIS197E, HIS241E, ILE203E, ILE296D, ILE298D, LEU223D, LEU239E, LEU248D, LEU255E, LEU325D, LYS205E, LYS238E, LYS249D, LYS267D, LYS320D, LYS51E, MET274D, MET275D, PHE221D, PHE342D, PHE347D, PRO196E, PRO219D, PRO256E, PRO271D, PRO271E, PRO346D, SER321D, THR237E, THR343D, THR345D, TRP222D, TRP250D, TYR235E, TYR52E, VAL164D, VAL233E, VAL276D
• D-F: ALA163D, ALA163F, ALA292D, ALA292F, ALA316D, ALA316F, ALA317D, ALA317F, ALA319D, ALA319F, ALA338D, ALA338F, ARG165D, ARG165F, ARG289D, ARG289F, ARG322D, ARG322F, ASN344D, ASN344F, ASN3D, ASN3F, ASN78F, ASP111D, ASP111F, ASP117D, ASP117F, ASP146D, ASP146F, ASP166D, ASP166F, ASP370D, ASP370F, ASP385D, ASP385F, CYS108D, CYS108F, GLN118D, GLN118F, GLN286D, GLN286F, GLN324D, GLN324F, GLN80D, GLN80F, GLU293D, GLU293F, GLU2D, GLU2F, GLU314D, GLU314F, GLU392D, GLU392F, GLY149D, GLY149F, GLY153D, GLY153F, GLY161D, GLY161F, GLY162D, GLY162F, GLY295D, GLY295F, GLY323D, GLY323F, GLY388D, GLY388F, GLY390D, GLY390F, GLY82D, GLY82F, HIS116D, HIS116F, HIS337D, HIS337F, ILE112D, ILE112F, ILE115D, ILE115F, ILE315D, ILE315F, ILE340D, ILE340F, ILE4D, ILE4F, LEU114D, LEU114F, LEU120D, LEU120F, LEU154D, LEU154F, LEU159D, LEU159F, LEU160D, LEU160F, LEU285D, LEU285F, LEU309D, LEU309F, LEU318D, LEU318F, LEU369D, LEU369F, LEU384D, LEU384F, LEU393D, LEU393F, LEU7D, LEU7F, LYS107D, LYS107F, LYS113D, LYS113F, LYS150D, LYS150F, LYS158D, LYS158F, LYS320D, LYS320F, LYS381D, LYS381F, LYS386D, LYS386F, LYS9D, LYS9F, MET1D, MET1F, MET299D, MET299F, MET5D, MET5F, PHE148D, PHE148F, PHE288D, PHE288F, PHE342D, PHE342F, PHE389D, PHE389F, PHE83D, PHE83F, PRO155D, PRO155F, PRO387D, PRO387F, SER110D, SER110F, SER287D, SER287F, SER321D, SER321F, SER382D, SER382F, THR284D, THR284F, THR290D, THR290F, THR310D, THR310F, THR311D, THR311F, THR341D, THR341F, THR343D, THR343F, THR6D, THR6F, THR81D, THR81F, TRP145D, TRP145F, TYR157D, TYR157F, VAL109D, VAL109F, VAL151D, VAL151F, VAL152D, VAL152F, VAL156D, VAL156F, VAL164D, VAL164F, VAL313D, VAL313F, VAL339D, VAL339F, VAL391D, VAL391F
• D-H: ALA163H, ALA201D, ALA236D, ALA240D, ALA270D, ALA272H, ARG165H, ARG204D, ARG214H, ARG268D, ARG268H, ARG322H, ARG53D, ASN234D, ASN247H, ASN269D, ASN344H, ASP166H, ASP198D, ASP200D, ASP220H, ASP232D, ASP297H, GLN169H, GLN259D, GLN324H, GLU261D, GLU265D, GLY199D, GLY202D, GLY262D, GLY273H, GLY295H, GLY323H, HIS197D, HIS241D, ILE203D, ILE296H, ILE298H, LEU223H, LEU239D, LEU248H, LEU255D, LEU325H, LYS238D, LYS249H, LYS267H, LYS320H, LYS51D, MET274H, MET275H, PHE221H, PHE342H, PHE347H, PRO196D, PRO219H, PRO256D, PRO271D, PRO271H, PRO346H, SER321H, THR237D, THR343H, THR345H, TRP222H, TRP250H, TYR235D, TYR52D, VAL164H, VAL233D, VAL276H
• E-F: ALA122E, ALA122F, ALA21E, ALA21F, ALA23E, ALA23F, ALA88E, ALA88F, ARG102E, ARG102F, ARG264E, ARG264F, ARG289E, ARG289F, ARG53E, ARG53F, ARG59E, ARG59F, ASN101E, ASN101F, ASN135E, ASN135F, ASN65E, ASN65F, ASP117E, ASP117F, ASP31E, ASP31F, ASP54E, ASP54F, CYS93E, CYS93F, GLN118E, GLN118F, GLN258E, GLN258F, GLN259E, GLN259F, GLN286E, GLN286F, GLN60E, GLN60F, GLU253E, GLU253F, GLU261E, GLU261F, GLU265E, GLU265F, GLU280E, GLU280F, GLU293E, GLU293F, GLU90E, GLU90F, GLU97E, GLU97F, GLY121E, GLY121F, GLY128E, GLY128F, GLY130E, GLY130F, GLY131E, GLY131F, GLY19E, GLY19F, GLY20E, GLY20F, GLY262E, GLY262F, GLY283E, GLY283F, GLY63E, GLY63F, GLY68E, GLY68F, GLY89E, GLY89F, GLY92E, GLY92F, HIS116E, HIS116F, HIS281E, HIS281F, HIS282E, HIS282F, HIS33E, HIS33F, HIS99E, HIS99F, ILE104E, ILE104F, ILE115E, ILE115F, ILE64E, ILE64F, ILE95E, ILE95F, LEU100E, LEU100F, LEU114E, LEU114F, LEU120E, LEU120F, LEU132E, LEU132F, LEU255E, LEU255F, LEU285E, LEU285F, LEU291E, LEU291F, LEU67E, LEU67F, LYS107E, LYS107F, LYS113E, LYS113F, LYS51E, LYS51F, LYS98E, LYS98F, MET119E, MET119F, MET124E, MET124F, MET134E, MET134F, MET229E, MET229F, MET49E, MET49F, MET91E, MET91F, PHE103E, PHE103F, PHE17E, PHE17F, PHE288E, PHE288F, PHE62E, PHE62F, PHE94E, PHE94F, PRO256E, PRO256F, PRO257E, PRO257F, PRO402E, PRO402F, PRO48E, PRO48F, SER127E, SER127F, SER129E, SER129F, SER230E, SER230F, SER287E, SER287F, SER404E, SER404F, SER50F, SER58E, SER61E, SER61F, THR123E, THR123F, THR136E, THR136F, THR22E, THR22F, THR284E, THR284F, THR290E, THR290F, THR47E, THR47F, THR87E, THR87F, TRP228E, TRP228F, TRP305E, TRP305F, TYR125E, TYR125F, TYR126E, TYR126F, TYR260E, TYR260F, TYR263E, TYR263F, TYR403E, TYR403F, TYR52E, TYR52F, TYR55E, TYR55F, VAL133E, VAL133F, VAL66E, VAL66F, VAL96E, VAL96F
• E-H: ARG268E, ARG268H
• F-G: ARG268F, ARG268G
• G-H: ALA122G, ALA122H, ALA21G, ALA21H, ALA23G, ALA23H, ALA88G, ALA88H, ARG102G, ARG102H, ARG264G, ARG264H, ARG289G, ARG289H, ARG53G, ARG53H, ARG59G, ARG59H, ASN101G, ASN101H, ASN135G, ASN135H, ASN65G, ASN65H, ASP117G, ASP117H, ASP31G, ASP31H, ASP34G, ASP54G, ASP54H, CYS93G, CYS93H, GLN118G, GLN118H, GLN258G, GLN258H, GLN259G, GLN259H, GLN286G, GLN286H, GLN60G, GLN60H, GLU253G, GLU253H, GLU261G, GLU261H, GLU265G, GLU265H, GLU280G, GLU280H, GLU293G, GLU293H, GLU90G, GLU90H, GLU97G, GLU97H, GLY121G, GLY121H, GLY128G, GLY128H, GLY130G, GLY130H, GLY131G, GLY131H, GLY19G, GLY19H, GLY20G, GLY20H, GLY262G, GLY262H, GLY283G, GLY283H, GLY63G, GLY63H, GLY68G, GLY68H, GLY89G, GLY89H, GLY92G, GLY92H, HIS116G, HIS116H, HIS281G, HIS281H, HIS282G, HIS282H, HIS33G, HIS33H, HIS405G, HIS405H, HIS99G, HIS99H, ILE104G, ILE104H, ILE115G, ILE115H, ILE64G, ILE64H, ILE95G, ILE95H, LEU100G, LEU100H, LEU114G, LEU114H, LEU120G, LEU120H, LEU132G, LEU132H, LEU255G, LEU255H, LEU285G, LEU285H, LEU291G, LEU291H, LEU67G, LEU67H, LYS107G, LYS107H, LYS113G, LYS113H, LYS51G, LYS51H, LYS98G, LYS98H, MET119G, MET119H, MET124G, MET124H, MET134G, MET134H, MET229G, MET229H, MET49G, MET49H, MET91G, MET91H, PHE103G, PHE103H, PHE17G, PHE17H, PHE288G, PHE288H, PHE62G, PHE62H, PHE94G, PHE94H, PRO256G, PRO256H, PRO257G, PRO257H, PRO402G, PRO402H, PRO48G, PRO48H, SER127G, SER127H, SER129G, SER129H, SER230G, SER230H, SER287G, SER287H, SER404G, SER404H, SER50G, SER50H, SER61G, SER61H, THR123G, THR123H, THR136G, THR136H, THR22G, THR22H, THR284G, THR284H, THR290G, THR290H, THR47G, THR47H, THR87G, THR87H, TRP228G, TRP228H, TRP305G, TRP305H, TYR125G, TYR125H, TYR126G, TYR126H, TYR260G, TYR260H, TYR263G, TYR263H, TYR403G, TYR403H, TYR52G, TYR52H, TYR55G, TYR55H, VAL133G, VAL133H, VAL66G, VAL66H, VAL96G, VAL96H