3CW2

crystal structure of the intact archaeal translation initiation factor 2 from sulfolobus solfataricus .

• Total interactions analyzed: 66
• Total true interactions: 19
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 75
  • Norm. En. per Res.: -3.9301
• Hub Node: B(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-34.5511	-33.1555	-139.666	-207.3726	57	10	0	5556	4	36	27
A-C	-35.1534	-8.8659	-244.234	-288.2533	75	14	8	10136	0	14	21
A-D	-6.392	20.5504	-81.3421	-67.1837	73	2	0	4229	0	43	38
A-K	-29.4643	-55.7524	-224.272	-309.4887	101	25	5	10212	3	32	45
B-C	-3.2986	17.9784	-86.9492	-72.2694	63	5	2	4419	0	48	41
B-D	-47.6926	-14.0201	-233.043	-294.7557	75	16	6	9744	0	15	18
B-K	0.0	0.0	-18.4493	-18.4493	22	2	1	1170	0	2	2
B-L	-18.1694	-65.0745	-167.029	-250.273	69	14	5	7551	4	19	25
B-M	-18.0941	-16.8298	-96.7401	-131.664	52	7	0	4054	0	10	9
D-M	0.0	0.0	-19.6362	-19.6362	23	1	0	1064	0	8	12
K-L	0.0	0.0	-6.2249	-6.2249	10	0	0	330	0	1	2
E-F	-40.0242	-23.6359	-157.166	-220.8261	61	12	0	5965	3	35	36
E-G	-55.6245	-15.075	-232.357	-303.0565	78	18	7	10022	1	13	20
E-H	-7.9585	25.9736	-99.7495	-81.7344	73	4	1	4421	1	42	39
E-M	-30.0028	-55.7229	-261.019	-346.7447	125	15	8	11989	3	35	39
F-G	0.0	31.1978	-107.757	-76.5592	69	4	1	4513	0	43	43
F-H	-29.2333	-31.8717	-223.883	-284.988	76	13	6	9791	1	12	20
F-M	-2.379	-6.4516	-70.4623	-79.2928	33	11	0	3034	0	11	19
F-N	0.0	-12.8362	-134.069	-146.9052	61	7	7	6407	3	22	19

Interface residues

• A-B: ALA2A, ALA2B, ARG43A, ASN224A, ASN224B, ASN231A, ASN231B, ASN55A, ASP283A, ASP283B, GLN229A, GLN229B, GLN7A, GLU232A, GLU232B, GLU284A, GLU284B, GLU285A, GLU285B, GLU288A, GLU288B, GLY227A, GLY227B, ILE279A, LEU233A, LEU233B, LEU41A, LYS225A, LYS225B, LYS234A, LYS234B, LYS248A, LYS287A, LYS287B, LYS290A, LYS42A, LYS5A, LYS5B, PHE230A, PHE230B, PHE286A, PHE286B, PHE85A, PHE85B, PRO226A, PRO226B, PRO4A, PRO4B, PRO72A, PRO72B, THR228A, THR228B, TRP3A, TRP3B, VAL223A, VAL6A, VAL6B
• A-C: ALA224C, ALA308A, ARG186C, ARG226C, ARG228C, ASN188C, ASN224A, ASN231A, ASN310A, ASP222A, ASP230C, ASP260C, ASP302A, GLN229A, GLU189C, GLU194C, GLU198C, GLU232A, GLU252A, GLU270A, GLY192C, GLY223C, GLY227A, GLY235A, GLY236A, ILE183C, ILE196C, ILE200C, ILE217C, ILE219C, ILE222C, ILE253A, ILE272A, LEU191C, LEU204C, LEU233A, LEU259A, LEU301A, LEU305A, LYS195C, LYS197C, LYS202C, LYS218C, LYS225A, LYS234A, LYS254A, LYS275A, LYS307A, PHE221A, PHE230A, PHE273A, PRO190C, PRO225C, PRO226A, PRO271A, PRO303A, SER201C, SER277A, SER304A, THR184C, THR187C, THR221C, THR228A, THR274A, THR299A, THR306A, TYR220C, TYR227C, TYR300A, VAL185C, VAL193C, VAL199C, VAL229C, VAL259C, VAL261A
• A-D: ALA143D, ALA168D, ALA172D, ALA2A, ARG207A, ARG226D, ARG228D, ARG87A, ASN143A, ASN216D, ASN391A, ASP208A, ASP230D, GLN211A, GLN7A, GLU146D, GLU148D, GLU166D, GLU167D, GLU173D, GLU174D, GLU199A, GLU200A, GLU60A, GLU82A, GLU9A, GLY147D, GLY223D, ILE150D, ILE159D, ILE202A, ILE219D, ILE222D, LEU151D, LEU182D, LEU209A, LEU215D, LEU86A, LYS142A, LYS145D, LYS149D, LYS162D, LYS170D, LYS176D, LYS178D, LYS197D, LYS203A, LYS212A, LYS218D, LYS287A, LYS290A, LYS5A, LYS84A, PHE286A, PHE85A, PRO163D, PRO205A, PRO4A, PRO83A, SER169D, SER210A, SER390A, THR204A, THR221D, TRP3A, TYR201A, TYR206A, TYR220D, VAL144D, VAL177D, VAL232D, VAL58A, VAL6A
• A-K: ALA129K, ALA159A, ALA185A, ALA67A, ARG13K, ARG164A, ASN149A, ASN177A, ASN190A, ASP113K, ASP12K, ASP152A, ASP192A, CYS109K, CYS127K, GLN148A, GLN162A, GLU157A, GLU158A, GLU176A, GLU196A, GLU200A, GLU20K, GLU25K, GLU39A, GLU40A, GLU4K, GLU66A, GLU6K, GLU9K, GLY197A, GLY22K, GLY31A, HIS187A, HIS37A, ILE125K, ILE166A, ILE180A, ILE181A, ILE189A, ILE191A, ILE195A, ILE32A, LEU11K, LEU128K, LEU14K, LEU160A, LEU186A, LEU18K, LEU194A, LEU41A, LYS110K, LYS117K, LYS118K, LYS150A, LYS156A, LYS167A, LYS171A, LYS17K, LYS188A, LYS21K, LYS24K, LYS36A, LYS42A, LYS5K, LYS63A, LYS64A, MET10K, PRO179A, PRO182A, PRO19K, PRO65A, SER107K, SER111K, SER155A, SER161A, SER16K, SER184A, SER193A, SER2K, SER35A, SER38A, SER3K, SER76A, THR108K, THR114K, TRP123K, TRP33A, TYR124K, TYR15K, TYR163A, TYR201A, TYR68A, TYR7K, VAL126K, VAL151A, VAL153A, VAL154A, VAL178A, VAL183A, VAL8K
• B-C: ALA143C, ALA168C, ALA2B, ARG207B, ARG228C, ARG87B, ASN391B, ASN392B, ASP208B, ASP230C, GLN211B, GLN244B, GLN7B, GLU146C, GLU148C, GLU166C, GLU167C, GLU173C, GLU174C, GLU60B, GLU82B, GLU9B, GLY147C, GLY223C, ILE150C, ILE159C, ILE222C, LEU165C, LEU182C, LEU209B, LEU86B, LYS142B, LYS145C, LYS149C, LYS162C, LYS170C, LYS176C, LYS178C, LYS197C, LYS203B, LYS212B, LYS218C, LYS287B, LYS5B, LYS84B, PHE286B, PHE85B, PRO205B, PRO4B, PRO83B, SER169C, SER210B, SER390B, THR204B, THR221C, TRP3B, TYR206B, TYR220C, VAL144C, VAL161C, VAL177C, VAL232C, VAL6B
• B-D: ALA203D, ALA224D, ALA319B, ARG186D, ARG226D, ARG228D, ARG260B, ASN188D, ASN216D, ASN224B, ASN231B, ASN310B, ASP222B, ASP260D, ASP302B, GLN229B, GLU189D, GLU194D, GLU198D, GLU232B, GLU252B, GLU270B, GLY192D, GLY223D, GLY227B, GLY235B, GLY236B, ILE196D, ILE200D, ILE217D, ILE219D, ILE222D, ILE253B, ILE272B, LEU191D, LEU204D, LEU233B, LEU259B, LEU301B, LEU305B, LYS195D, LYS197D, LYS202D, LYS218D, LYS225B, LYS234B, LYS254B, LYS275B, LYS307B, PHE230B, PHE273B, PRO190D, PRO225D, PRO226B, PRO271B, PRO303B, SER201D, SER277B, SER304B, THR184D, THR187D, THR221D, THR228B, THR274B, THR299B, THR306B, TYR220D, TYR227D, TYR300B, VAL185D, VAL193D, VAL199D, VAL229D, VAL259D, VAL261B
• B-K: ARG280B, ASP283B, CYS127K, GLN27B, GLY31B, HIS187B, HIS20B, ILE125K, ILE32B, ILE60K, LEU128K, LYS121K, LYS188B, LYS67K, SER122K, SER35B, THR30B, THR34B, THR46B, TRP33B, TYR124K, VAL126K
• B-L: ALA120B, ALA159B, ALA175B, ALA185B, ALA67B, ARG13L, ARG164B, ASN149B, ASN177B, ASN190B, ASP12L, ASP152B, ASP192B, GLN148B, GLN162B, GLU157B, GLU158B, GLU176B, GLU196B, GLU200B, GLU4L, GLU66B, GLU6L, GLU9L, GLY197B, HIS187B, ILE145B, ILE180B, ILE181B, ILE189B, ILE191B, ILE195B, LEU11L, LEU14L, LEU160B, LEU18L, LEU194B, LYS150B, LYS156B, LYS167B, LYS17L, LYS188B, LYS5L, LYS63B, LYS64B, MET10L, PRO179B, PRO182B, PRO19L, PRO65B, SER155B, SER161B, SER16L, SER184B, SER193B, SER2L, SER3L, SER76B, TYR15L, TYR163B, TYR201B, TYR68B, TYR7L, VAL151B, VAL153B, VAL154B, VAL178B, VAL183B, VAL8L
• B-M: ALA319B, ALA321B, ARG260B, ARG45M, ASN37M, ASN40M, ASN46M, ASP320B, GLN264B, GLN90M, GLU252B, GLU262B, GLU270B, GLU322B, GLU80M, GLY258B, GLY39M, ILE272B, ILE34M, ILE35M, ILE38M, ILE43M, LEU256B, LEU259B, LEU305B, LEU30M, LEU318B, LEU36M, LYS254B, LYS263B, LYS266B, LYS275B, LYS78M, LYS86M, MET33M, PHE273B, PHE87M, PRO257B, PRO271B, SER268B, SER88M, SER89M, THR317B, THR41M, TRP327B, TYR269B, TYR300B, VAL255B, VAL261B, VAL267B, VAL323B, VAL325B
• D-M: ARG186D, ARG45M, ASN188D, ASN258D, ASN37M, ASN40M, ASN74M, ASP76M, GLU189D, GLU194D, GLU256D, GLU257D, GLU80M, GLY39M, ILE43M, LEU191D, LYS195D, LYS78M, PRO190D, THR187D, THR41M, THR42M, VAL82M
• K-L: ALA70K, ALA71K, GLU20L, GLU68K, GLY22L, LEU69K, LYS21L, LYS67K, LYS86K, PRO19L
• E-F: ALA2E, ALA2F, ARG88E, ASN224E, ASN224F, ASN231E, ASN231F, ASP283E, ASP283F, GLN229E, GLN229F, GLN7E, GLN7F, GLU232E, GLU232F, GLU284E, GLU284F, GLU285E, GLU285F, GLU288E, GLU288F, GLU39E, GLU40E, GLU40F, GLY227E, GLY227F, ILE279E, ILE279F, LEU233E, LEU233F, LYS225E, LYS225F, LYS234E, LYS234F, LYS248E, LYS287E, LYS287F, LYS290E, LYS5E, LYS5F, PHE230E, PHE230F, PHE286E, PHE286F, PHE85E, PHE85F, PRO226E, PRO226F, PRO4E, PRO4F, PRO72E, PRO72F, THR228E, THR228F, TRP3E, TRP3F, VAL223E, VAL223F, VAL249E, VAL6E, VAL6F
• E-G: ALA203G, ALA224G, ALA308E, ALA319E, ARG186G, ARG226G, ARG228G, ARG260E, ASN188G, ASN216G, ASN224E, ASN231E, ASN310E, ASP222E, ASP230G, ASP260G, ASP302E, GLN229E, GLU189G, GLU194G, GLU198G, GLU208G, GLU232E, GLU252E, GLU270E, GLY192G, GLY223G, GLY227E, GLY235E, GLY236E, ILE183G, ILE196G, ILE200G, ILE217G, ILE219G, ILE222G, ILE253E, ILE272E, LEU191G, LEU204G, LEU233E, LEU259E, LEU301E, LEU305E, LYS195G, LYS197G, LYS202G, LYS218G, LYS225E, LYS234E, LYS275E, LYS307E, PHE230E, PHE273E, PRO190G, PRO225G, PRO226E, PRO271E, PRO303E, SER201G, SER277E, SER304E, THR184G, THR187G, THR221G, THR228E, THR274E, THR299E, THR306E, TYR220G, TYR227G, TYR300E, VAL185G, VAL193G, VAL199G, VAL229G, VAL259G, VAL261E
• E-H: ALA143H, ALA168H, ALA2E, ARG207E, ARG226H, ARG228H, ARG87E, ARG88E, ASN216H, ASP208E, ASP230H, GLN211E, GLN244E, GLN7E, GLU146H, GLU148H, GLU166H, GLU167H, GLU173H, GLU174H, GLU176E, GLU200E, GLU60E, GLU82E, GLU9E, GLY147H, GLY223H, HIS171H, ILE150H, ILE152H, ILE217H, ILE219H, ILE222H, LEU164H, LEU165H, LEU182H, LEU209E, LEU86E, LYS113H, LYS142E, LYS145H, LYS149H, LYS162H, LYS170H, LYS176H, LYS178H, LYS197H, LYS203E, LYS212E, LYS218H, LYS287E, LYS290E, LYS5E, LYS84E, PHE85E, PRO163H, PRO205E, PRO4E, PRO83E, SER169H, SER180H, SER210E, THR204E, THR221H, TRP3E, TYR206E, TYR220H, TYR227H, VAL144H, VAL177H, VAL232H, VAL58E, VAL6E
• E-M: ALA119E, ALA120E, ALA132M, ALA159E, ALA185E, ALA28E, ALA67E, ARG13M, ARG164E, ARG23M, ARG88E, ASN149E, ASN177E, ASN190E, ASN55E, ASP12M, ASP152E, ASP192E, ASP283E, CYS109M, CYS127M, CYS130M, CYS74E, GLN133M, GLN148E, GLN162E, GLN168E, GLN27E, GLU105M, GLU157E, GLU158E, GLU176E, GLU196E, GLU200E, GLU20M, GLU25M, GLU284E, GLU40E, GLU4M, GLU53E, GLU66E, GLU6M, GLU71E, GLU9M, GLY131M, GLY197E, GLY22M, GLY31E, HIS187E, ILE145E, ILE146E, ILE166E, ILE180E, ILE181E, ILE189E, ILE191E, ILE29E, ILE32E, LEU11M, LEU139M, LEU14M, LEU160E, LEU186E, LEU18M, LEU194E, LYS110M, LYS121M, LYS137M, LYS150E, LYS156E, LYS167E, LYS171E, LYS17M, LYS188E, LYS21M, LYS24M, LYS5M, LYS63E, LYS75E, MET10M, PRO135M, PRO138M, PRO179E, PRO182E, PRO19M, PRO65E, PRO72E, SER107M, SER111M, SER122M, SER155E, SER161E, SER16M, SER184E, SER193E, SER2M, SER35E, SER38E, SER3M, SER73E, SER76E, THR108M, THR134M, THR30E, THR34E, THR54E, THR70E, TRP123M, TRP33E, TYR15M, TYR163E, TYR201E, TYR68E, TYR7M, VAL126M, VAL136M, VAL147E, VAL151E, VAL153E, VAL154E, VAL178E, VAL183E, VAL26E, VAL69E, VAL8M
• F-G: ALA143G, ALA168G, ALA2F, ARG207F, ARG228G, ARG87F, ASN216G, ASN391F, ASP208F, ASP230G, GLN211F, GLU146G, GLU148G, GLU158G, GLU166G, GLU167G, GLU173G, GLU174G, GLU60F, GLU82F, GLU9F, GLY147G, GLY223G, ILE150G, ILE159G, ILE219G, ILE222G, LEU151G, LEU165G, LEU209F, LEU215G, LEU86F, LYS113G, LYS142F, LYS142G, LYS145G, LYS149G, LYS162G, LYS170G, LYS176G, LYS178G, LYS197G, LYS203F, LYS212F, LYS218G, LYS287F, LYS290F, LYS5F, LYS84F, PHE85F, PRO163G, PRO205F, PRO213F, PRO4F, PRO72F, PRO83F, SER169G, SER180G, SER210F, SER390F, THR204F, THR221G, TRP3F, TYR206F, TYR220G, VAL144G, VAL177G, VAL232G, VAL6F
• F-H: ALA203H, ALA224H, ALA308F, ALA319F, ARG186H, ARG226H, ARG228H, ARG260F, ASN188H, ASN216H, ASN224F, ASN231F, ASN310F, ASP222F, ASP302F, GLN229F, GLU189H, GLU194H, GLU198H, GLU232F, GLU252F, GLU270F, GLY192H, GLY223H, GLY227F, GLY235F, GLY236F, ILE196H, ILE200H, ILE217H, ILE219H, ILE222H, ILE253F, ILE272F, LEU191H, LEU204H, LEU233F, LEU259F, LEU301F, LEU305F, LYS195H, LYS197H, LYS202H, LYS218H, LYS225F, LYS234F, LYS254F, LYS275F, LYS307F, PHE230F, PHE273F, PRO190H, PRO225H, PRO226F, PRO271F, PRO303F, SER201H, SER277F, SER304F, THR184H, THR187H, THR221H, THR228F, THR274F, THR299F, THR306F, TYR220H, TYR227H, TYR300F, VAL185H, VAL193H, VAL199H, VAL223F, VAL229H, VAL259H, VAL261F
• F-M: ARG43F, GLN27F, GLU119M, GLU39F, GLU40F, GLY31F, HIS20F, HIS37F, ILE125M, ILE32F, LEU186F, LEU41F, LYS117M, LYS118M, LYS120M, LYS121M, LYS137M, LYS225F, LYS36F, LYS42F, LYS48F, LYS63M, PRO135M, PRO138M, PRO226F, SER122M, SER35F, SER38F, THR24F, TRP123M, TRP33F, TYR124M, VAL136M
• F-N: ALA120F, ALA159F, ARG13N, ARG164F, ASN177F, ASN190F, ASP12N, ASP152F, GLN148F, GLN162F, GLU157F, GLU158F, GLU176F, GLU196F, GLU200F, GLU4N, GLU66F, GLU6N, GLU9N, GLY197F, HIS187F, ILE166F, ILE180F, ILE181F, ILE189F, ILE191F, LEU11N, LEU14N, LEU160F, LEU186F, LEU18N, LEU194F, LYS150F, LYS156F, LYS167F, LYS17N, LYS188F, LYS64F, MET10N, PRO179F, PRO182F, PRO19N, PRO65F, SER155F, SER161F, SER16N, SER184F, SER193F, SER2N, SER3N, TYR15N, TYR163F, TYR201F, TYR7N, VAL147F, VAL151F, VAL153F, VAL154F, VAL178F, VAL183F, VAL8N