3CW1

crystal structure of human spliceosomal u1 snrnp

• Total interactions analyzed: 780
• Total true interactions: 42
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 22
  • Norm. En. per Res.: -0.2008
• Hub Node: D(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
D-A	0.0	0.0	-1.3168	-1.3168	23	0	0	308	0	0	0
D-G	0.0	0.0	-1.9334	-1.9334	23	0	0	337	0	0	0
D-K	0.0	0.0	-1.7425	-1.7425	21	0	0	221	0	0	0
D-L	0.0	0.0	-0.4233	-0.4233	8	0	0	64	0	0	0
A-B	0.0	0.0	-4.4172	-4.4172	22	0	0	386	0	0	0
A-K	0.0	0.0	-0.0985	-0.0985	5	0	0	36	0	0	0
B-C	0.0	0.0	-2.6639	-2.6639	24	0	0	430	0	0	0
C-F	0.0	0.0	-4.0963	-4.0963	31	0	0	592	0	0	0
F-E	0.0	0.0	-4.3915	-4.3915	26	0	0	435	0	0	0
E-G	0.0	0.0	-2.8098	-2.8098	36	0	0	618	0	0	0
S-H	0.0	0.0	-3.4252	-3.4252	25	0	0	460	0	0	0
S-3	0.0	0.0	-2.665	-2.665	27	0	0	444	0	0	0
S-6	0.0	0.0	-1.9153	-1.9153	19	0	0	222	0	0	0
S-9	0.0	0.0	-1.0881	-1.0881	9	0	0	96	0	0	0
H-M	0.0	0.0	-2.2965	-2.2965	15	0	0	313	0	0	0
H-6	0.0	0.0	-0.1514	-0.1514	10	0	0	67	0	0	0
M-P	0.0	0.0	-6.0151	-6.0151	36	0	0	709	0	0	0
P-Z	0.0	0.0	-0.7486	-0.7486	23	0	0	199	0	0	0
Z-W	0.0	0.0	-4.1214	-4.1214	25	0	0	502	0	0	0
W-3	0.0	0.0	-1.2729	-1.2729	31	0	0	429	0	0	0
T-I	0.0	0.0	-3.4574	-3.4574	22	0	0	460	0	0	0
T-4	0.0	0.0	-2.6774	-2.6774	26	0	0	445	0	0	0
T-7	0.0	0.0	-0.5999	-0.5999	16	0	0	98	0	0	0
T-0	0.0	0.0	-0.8089	-0.8089	14	0	0	137	0	0	0
I-N	0.0	0.0	-2.2778	-2.2778	15	0	0	315	0	0	0
I-7	0.0	0.0	-0.0251	-0.0251	5	0	0	22	0	0	0
N-Q	0.0	0.0	-7.0834	-7.0834	38	0	0	751	0	0	0
Q-1	0.0	0.0	-0.7077	-0.7077	21	0	0	181	0	0	0
1-X	0.0	0.0	-2.9901	-2.9901	21	0	0	386	0	0	0
X-4	0.0	0.0	-1.267	-1.267	32	0	0	425	0	0	0
7-0	0.0	0.0	-0.0006	-0.0006	4	0	0	2	0	0	0
U-J	0.0	0.0	-3.4461	-3.4461	24	0	0	457	0	0	0
U-5	0.0	0.0	-2.6523	-2.6523	26	0	0	445	0	0	0
U-8	0.0	0.0	-0.5962	-0.5962	15	0	0	90	0	0	0
U-l	0.0	0.0	-0.0187	-0.0187	7	0	0	17	0	0	0
J-O	0.0	0.0	-2.2834	-2.2834	15	0	0	314	0	0	0
J-8	0.0	0.0	-0.1307	-0.1307	9	0	0	54	0	0	0
O-R	0.0	0.0	-5.1048	-5.1048	34	0	0	633	0	0	0
R-2	0.0	0.0	-0.8827	-0.8827	25	0	0	232	0	0	0
2-Y	0.0	0.0	-4.3025	-4.3025	26	0	0	535	0	0	0
Y-5	0.0	0.0	-1.2522	-1.2522	32	0	0	421	0	0	0
5-l	0.0	0.0	-0.0449	-0.0449	2	0	0	17	0	0	0

Interface residues

• D-A: ALA33A, ARG69D, ARG73A, ASN76A, ASP35A, ASP75D, GLU75A, GLY68A, GLY74A, ILE68D, ILE72D, ILE7D, LEU67A, LEU69A, LEU71A, LEU71D, LEU72A, LEU73D, LYS32A, PHE70D, PRO74D, PRO81D, VAL70A
• D-G: ALA72G, ARG64D, ARG75G, ASN40D, CYS41D, GLN42D, GLN60D, GLU34D, GLU36D, GLU59D, GLU71G, GLU74G, GLU8G, HIS5G, ILE63D, ILE68G, LEU70G, LEU73G, LYS67D, MET69G, PRO7G, TYR62D, VAL61D
• D-K: ALA14K, ARG16K, ARG29D, ARG51D, ASP52D, ASP75D, GLY53D, HIS16D, ILE17D, ILE72D, LEU22K, LEU73D, PHE13K, PRO15K, PRO18K, PRO23K, PRO74D, THR19D, THR49D, TYR50D, VAL18D
• D-L: ASN38D, ASP16L, ASP37D, GLU36D, LYS8D, PRO18L, SER17L, TYR5L
• A-B: ARG61B, ASN63B, ASN64B, ASN76A, GLN22A, GLU56B, GLU75A, GLY62B, HIS37A, ILE60B, ILE65B, LEU55B, LEU58B, LEU77A, MET80A, SER35B, SER59B, SER79A, THR57B, THR81A, VAL78A, VAL82A
• A-K: ARG65A, ILE19K, LEU67A, PRO20K, VAL66A
• B-C: ALA58C, ARG102C, ARG66B, ASP104C, ASP60C, ASP72B, GLY103C, ILE65B, ILE69B, LEU101C, LEU3B, LEU70B, LEU76B, LYS20B, LYS57C, LYS98C, MET99C, PHE100C, PHE68B, PRO71B, SER105C, SER97C, TYR67B, VAL66C
• C-F: ARG111C, ARG65F, ASN112C, ASN41F, ASN67F, ASN68F, ASP37F, CYS66F, GLN43F, GLU23C, GLU61F, GLY27C, GLY38F, GLY60F, ILE107C, ILE64F, LEU110C, LEU114C, LEU59F, LEU63F, MET42F, PRO113C, PRO28C, SER35F, THR26C, VAL106C, VAL108C, VAL109C, VAL34F, VAL36F, VAL62F
• F-E: ARG73F, ARG76E, ASN83E, ASP51E, GLU76F, GLY49E, GLY74F, GLY75E, GLY81E, ILE48E, ILE72F, ILE77E, LEU56E, LEU70F, LEU74E, LEU79E, LYS24F, LYS80E, LYS8F, MET78E, PHE50E, PRO7F, TYR71F, VAL57E, VAL69F, VAL75F
• E-G: ARG23E, ARG63G, ASN19E, ASN22G, ASN39G, ASN55G, ASN56G, ASN92E, ASP35G, GLN38E, GLN54G, GLN88E, GLU37E, GLY23G, GLY33G, GLY58G, ILE21E, ILE57G, ILE62G, LEU21G, LEU40G, LEU86E, LEU87E, MET54E, MET59G, PHE22E, PHE34G, SER66G, SER89E, SER91E, THR85E, TYR53E, VAL41G, VAL60G, VAL61G, VAL90E
• S-H: ARG269S, ARG273H, ASN239H, ASN276H, ASP235H, ASP275S, GLU275H, GLY268H, GLY274H, ILE207S, ILE241H, ILE268S, ILE272S, LEU210S, LEU267H, LEU269H, LEU271H, LEU271S, LEU272H, LEU273S, MET276S, PHE270S, PRO274S, VAL209S, VAL270H
• S-3: ALA2723, ARG264S, ARG2753, ASN240S, CYS241S, GLN242S, GLN260S, GLU2083, GLU234S, GLU236S, GLU259S, GLU2713, GLU2743, HIS2053, ILE263S, ILE2683, LEU258S, LEU2703, LEU2733, LYS2113, LYS267S, MET2693, PRO2073, THR222S, TYR262S, VAL261S, VAL2763
• S-6: ALA2146, ARG2166, ARG229S, ARG251S, ASP252S, ASP275S, GLY253S, HIS216S, ILE217S, LEU2226, LEU273S, PHE2136, PRO2156, PRO2186, PRO2236, PRO274S, THR219S, TYR250S, VAL218S
• S-9: ALA235S, ALA280S, ASP2079, ASP2169, ASP237S, GLU236S, PRO2189, SER2179, SER2199
• H-M: ARG261M, ASN264M, GLU256M, GLU283H, ILE260M, LEU255M, LEU258M, LEU277H, MET280H, SER259M, SER279H, THR257M, THR281H, VAL278H, VAL282H
• H-6: ARG265H, ASP2176, GLY268H, ILE2196, LEU267H, LEU269H, PRO2156, PRO2186, PRO2206, VAL266H
• M-P: ALA258P, ARG261P, ARG266M, ARG302P, ASN263M, ASN264P, ASP260P, ASP272M, ASP277M, ASP304P, GLU268P, GLY303P, HIS262P, ILE265M, ILE269M, ILE296P, LEU203M, LEU270M, LEU274M, LEU276M, LEU301P, LYS220M, LYS257P, LYS298P, MET299P, PHE206M, PHE259P, PHE268M, PHE300P, PRO271M, SER273M, SER297P, SER305P, TYR267M, VAL204M, VAL266P
• P-Z: ARG265Z, ARG311P, ASN312P, ASP237Z, GLN243Z, GLU223P, GLU261Z, GLY227P, GLY260Z, ILE264Z, ILE307P, LEU244Z, LEU263Z, LEU310P, MET242Z, PRO228P, SER235Z, THR226P, VAL234Z, VAL236Z, VAL262Z, VAL308P, VAL309P
• Z-W: ARG273Z, ARG276W, ASN255W, ASN283W, ASP251W, GLY249W, GLY274Z, GLY275W, ILE248W, ILE272Z, ILE277W, LEU256W, LEU270Z, LEU274W, LEU279W, LYS208Z, LYS280W, MET278W, PHE250W, PRO207Z, PRO209Z, TYR271Z, VAL257W, VAL269Z, VAL275Z
• W-3: ARG2633, ASN219W, ASN2393, ASN2553, ASN2563, ASN2653, ASN292W, ASP2353, ASP282W, GLN238W, GLN288W, GLY2233, GLY2333, ILE221W, ILE2573, ILE2623, LEU220W, LEU2403, LEU286W, LEU287W, MET254W, MET2593, PHE222W, PHE2343, SER2663, SER291W, THR285W, TYR253W, VAL2413, VAL2603, VAL2613
• T-I: ARG469T, ARG473I, ASN423T, ASN476I, ASP434I, ASP475T, GLU475I, GLY468I, GLY474I, ILE407T, ILE468T, ILE472T, LEU467I, LEU469I, LEU471I, LEU471T, LEU472I, LEU473T, MET476T, PHE470T, PRO474T, VAL470I
• T-4: ALA4724, ARG464T, ARG4754, ASN440T, CYS441T, GLN442T, GLN460T, GLU4084, GLU434T, GLU436T, GLU459T, GLU4714, GLU4744, HIS4054, ILE463T, ILE4684, LEU458T, LEU4704, LEU4734, LYS467T, MET4694, PRO4074, THR422T, TYR462T, VAL461T, VAL4764
• T-7: ALA4147, ARG4167, ARG429T, ARG451T, ASP452T, ASP475T, HIS416T, ILE417T, LEU4227, LEU473T, PHE4137, PRO4157, PRO4187, PRO4237, PRO474T, VAL418T
• T-0: ALA480T, ASN438T, ASN479T, ASP4070, ASP4160, ASP437T, CYS4060, GLU436T, LYS408T, PRO4180, PRO481T, SER4170, TYR4050, TYR4080
• I-N: ARG461N, ASN463N, ASN464N, GLU456N, GLU483I, ILE460N, LEU458N, LEU477I, MET480I, SER459N, SER479I, THR457N, THR481I, VAL478I, VAL482I
• I-7: ARG465I, ILE4197, LEU467I, PRO4207, VAL466I
• N-Q: ALA458Q, ARG447Q, ARG461Q, ARG466N, ARG502Q, ASN463N, ASN464Q, ASP460Q, ASP472N, ASP477N, ASP504Q, CYS463Q, GLU468Q, GLY503Q, HIS462Q, ILE465N, ILE469N, ILE496Q, LEU403N, LEU470N, LEU474N, LEU476N, LEU501Q, LYS420N, LYS457Q, LYS498Q, MET499Q, PHE406N, PHE459Q, PHE468N, PHE500Q, PRO471N, SER473N, SER497Q, SER505Q, TYR467N, VAL404N, VAL466Q
• Q-1: ARG4651, ARG511Q, ASP4371, GLN4431, GLU423Q, GLU4611, GLY427Q, ILE4641, ILE507Q, LEU4441, LEU4631, LEU510Q, MET4421, PRO428Q, SER4351, THR426Q, VAL4341, VAL4361, VAL4621, VAL508Q, VAL509Q
• 1-X: ARG4731, ARG476X, ASN483X, ASP451X, GLU4761, GLY449X, GLY4741, GLY475X, ILE4721, ILE477X, LEU4701, LEU474X, LEU479X, LYS4081, LYS480X, MET478X, PHE450X, PRO4091, TYR4711, VAL4691, VAL4751
• X-4: ARG423X, ARG4634, ASN419X, ASN4394, ASN4554, ASN4564, ASN4654, ASN492X, ASP4354, ASP482X, GLN438X, GLN488X, GLY4234, GLY4334, ILE421X, ILE4574, ILE4624, LEU420X, LEU4404, LEU486X, LEU487X, MET454X, MET4594, PHE422X, PHE4344, SER4664, SER491X, THR485X, TYR453X, VAL4414, VAL4604, VAL4614
• 7-0: ALA4117, LEU4127, MET4420, TYR4380
• U-J: ARG669U, ARG673J, ASN676J, ASP635J, ASP675U, GLU675J, GLY668J, GLY674J, ILE607U, ILE641J, ILE668U, ILE672U, LEU610U, LEU667J, LEU669J, LEU671J, LEU671U, LEU672J, LEU673U, MET676U, PHE670U, PRO674U, VAL609U, VAL670J
• U-5: ALA6725, ARG664U, ARG6755, ASN640U, CYS641U, GLN642U, GLN660U, GLU6085, GLU634U, GLU636U, GLU659U, GLU6715, GLU6745, HIS6055, ILE663U, ILE6685, LEU658U, LEU6705, LEU6735, LYS667U, MET6695, PRO6075, THR622U, TYR662U, VAL661U, VAL6765
• U-8: ALA6148, ARG6168, ARG651U, ASP652U, ASP675U, HIS616U, ILE617U, LEU6128, LEU6228, LEU673U, PHE6138, PRO6158, PRO6238, PRO674U, VAL618U
• U-l: ALA680U, ASP607l, ASP616l, ASP637U, GLU636U, PRO618l, SER617l
• J-O: ARG661O, ASN664O, GLU656O, GLU683J, ILE660O, LEU655O, LEU658O, LEU677J, MET680J, SER659O, SER679J, THR657O, THR681J, VAL678J, VAL682J
• J-8: ARG665J, ASP6178, GLY668J, ILE6198, LEU667J, PRO6158, PRO6188, PRO6208, VAL666J
• O-R: ALA658R, ARG661R, ARG666O, ARG702R, ASN663O, ASN664R, ASP660R, ASP672O, ASP677O, ASP704R, GLU668R, GLY703R, HIS662R, ILE665O, ILE669O, ILE696R, LEU603O, LEU670O, LEU674O, LEU676O, LEU701R, LYS620O, LYS657R, LYS698R, MET699R, PHE606O, PHE668O, PHE700R, PRO671O, SER673O, SER697R, SER705R, TYR667O, VAL666R
• R-2: ARG6652, ARG711R, ASN712R, ASP6372, GLN6432, GLU623R, GLU6612, GLY627R, GLY6602, ILE6642, ILE707R, LEU6442, LEU6592, LEU6632, LEU710R, MET6422, PRO628R, PRO713R, SER6352, THR626R, VAL6342, VAL6362, VAL6622, VAL708R, VAL709R
• 2-Y: ARG6732, ARG676Y, ASN655Y, ASN683Y, ASP651Y, GLU6762, GLY649Y, GLY6742, GLY675Y, ILE648Y, ILE6722, ILE677Y, LEU656Y, LEU6702, LEU674Y, LEU679Y, LYS6082, LYS680Y, MET678Y, PHE650Y, PRO6072, PRO6092, TYR6712, VAL657Y, VAL6692, VAL6752
• Y-5: ARG623Y, ARG6635, ASN619Y, ASN6395, ASN6555, ASN6565, ASN6655, ASN692Y, ASP6355, ASP682Y, GLN638Y, GLN688Y, GLY6235, GLY6335, ILE621Y, ILE6575, ILE6625, LEU620Y, LEU6405, LEU686Y, LEU687Y, MET654Y, MET6595, PHE622Y, PHE6345, SER6665, SER691Y, THR685Y, TYR653Y, VAL6415, VAL6605, VAL6615
• 5-l: PRO6075, PRO618l