3CHX

crystal structure of methylosinus trichosporium ob3b particulate methane monooxygenase (pmmo)

• Total interactions analyzed: 105
• Total true interactions: 33
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 193
  • Norm. En. per Res.: -3.568
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-30.6179	-28.1239	-851.016	-909.7577	272	164	29	41950	3	34	32
A-C	-6.2083	-5.7218	-62.8069	-74.737	61	8	1	4058	0	19	14
A-D	0.0	0.0	-32.1458	-32.1458	19	10	0	1563	0	0	0
A-E	-26.6537	-28.7698	-120.841	-176.2645	61	12	0	5352	1	8	8
A-F	0.0	0.0	-47.4326	-47.4326	41	6	2	2395	0	9	7
A-I	-30.0316	-33.3829	-131.063	-194.4775	63	11	1	5784	2	9	9
B-C	-53.6984	-43.0393	-587.033	-683.7707	193	86	15	24406	9	32	28
B-D	0.0	0.0	-84.5026	-84.5026	66	20	0	6628	0	0	0
B-F	0.0	0.0	-85.8892	-85.8892	43	13	6	4104	0	2	2
B-I	0.0	0.0	-51.2817	-51.2817	42	5	2	2533	0	10	7
B-J	0.0	0.0	-80.1814	-80.1814	44	19	6	4427	0	2	2
B-K	0.0	0.0	-1.3008	-1.3008	9	0	0	146	0	2	0
C-D	0.0	0.0	-25.6104	-25.6104	40	7	0	2525	0	0	0
C-M	0.0	0.0	-119.009	-119.009	75	45	0	7416	0	0	0
C-F	0.0	0.0	-1.0049	-1.0049	9	0	0	114	0	1	0
E-F	-17.7224	-28.1239	-855.543	-901.3893	273	164	29	41976	3	34	32
E-G	0.0	-5.7219	-62.4343	-68.1562	57	8	1	4041	0	19	14
E-H	0.0	0.0	-30.3136	-30.3136	19	12	0	1568	0	0	0
E-I	-30.4563	-32.0231	-135.762	-198.2414	62	16	1	5756	2	9	9
E-J	0.0	0.0	-50.8088	-50.8088	42	8	2	2519	0	9	7
F-G	-58.4852	-43.036	-578.015	-679.5363	193	88	15	24384	9	32	28
F-H	0.0	0.0	-84.5115	-84.5115	66	20	0	6621	0	0	0
F-J	0.0	0.0	-83.6336	-83.6336	45	26	7	4581	0	2	2
G-H	0.0	0.0	-25.2436	-25.2436	40	7	0	2501	0	0	0
G-N	0.0	0.0	-118.456	-118.456	76	51	0	7552	0	0	0
G-J	0.0	0.0	-1.3275	-1.3275	9	0	0	141	0	2	0
I-J	-26.6153	-28.1215	-856.785	-911.5219	272	164	29	41998	3	34	32
I-K	0.0	-5.7222	-62.5454	-68.2676	57	8	1	4048	0	19	14
I-L	0.0	0.0	-31.7933	-31.7933	19	10	0	1564	0	0	0
J-K	-59.2507	-43.0419	-586.339	-688.6316	193	89	15	24422	9	32	28
J-L	0.0	0.0	-84.555	-84.555	66	20	0	6625	0	0	0
K-L	0.0	0.0	-25.6535	-25.6535	40	7	0	2516	0	0	0
K-O	0.0	0.0	-119.14	-119.14	75	44	0	7421	0	0	0

Interface residues

• A-B: ALA109A, ALA117A, ALA128B, ALA133B, ALA140A, ALA168B, ALA170B, ALA171B, ALA175B, ALA186B, ALA197A, ALA19B, ALA205A, ALA206A, ALA207A, ALA208A, ALA20B, ALA221A, ALA244A, ALA248A, ALA253A, ALA259A, ALA273A, ALA94B, ALA98A, ARG107A, ARG109B, ARG119A, ARG138A, ARG139A, ARG194A, ARG195B, ARG225A, ARG240A, ARG241A, ARG267A, ARG62B, ARG63B, ASN150A, ASN164B, ASN165B, ASN262A, ASN87B, ASN97A, ASP134A, ASP137B, ASP175A, ASP181A, ASP186A, ASP187B, ASP193A, ASP231A, ASP237A, ASP238A, ASP239A, ASP27B, ASP54B, ASP58B, ASP61B, CYS22B, GLN110A, GLN115A, GLN148A, GLN174B, GLN178B, GLN181B, GLN234A, GLN272A, GLN276A, GLU100A, GLU105B, GLU152A, GLU177B, GLU188A, GLU232A, GLU233A, GLU86B, GLY100B, GLY102A, GLY104B, GLY115B, GLY141A, GLY144B, GLY153B, GLY155A, GLY156B, GLY180B, GLY182A, GLY190B, GLY191A, GLY218A, GLY236A, GLY243A, GLY257A, GLY93B, GLY99A, HIS173B, HIS179B, HIS192B, HIS199A, HIS40A, ILE103B, ILE107B, ILE112A, ILE121B, ILE133A, ILE138B, ILE139B, ILE158A, ILE169B, ILE192A, ILE195A, ILE204A, ILE210A, ILE219A, ILE220A, ILE226A, ILE235A, ILE245A, ILE249B, ILE251A, ILE255A, ILE256A, ILE269A, LEU101B, LEU102B, LEU105A, LEU123B, LEU129B, LEU134B, LEU135A, LEU136B, LEU141B, LEU142B, LEU160B, LEU172B, LEU179A, LEU180A, LEU182B, LEU185B, LEU187A, LEU188B, LEU211A, LEU224A, LEU247A, LEU271A, LEU275A, LEU31B, LEU33B, LEU34B, LEU90B, LEU96A, LYS136A, LYS174A, LYS216A, LYS217A, LYS230A, LYS247B, LYS24B, LYS60B, LYS89B, MET140B, MET170A, MET183B, MET198B, MET203A, MET29B, PHE111A, PHE113B, PHE116A, PHE119B, PHE125B, PHE13B, PHE161B, PHE173A, PHE191B, PHE193B, PHE200A, PHE214A, PHE215A, PHE224B, PHE265A, PHE30B, PHE35B, PHE83B, PHE84B, PHE88B, PHE92B, PHE95A, PHE96B, PRO101A, PRO103A, PRO118A, PRO120B, PRO126B, PRO132B, PRO156A, PRO163B, PRO167B, PRO176A, PRO199B, PRO201A, PRO266A, PRO270A, PRO91B, SER122B, SER127B, SER143B, SER184B, SER197B, SER222A, SER227A, SER263A, SER99B, THR108A, THR117B, THR176B, THR178A, THR183A, THR184A, THR189A, THR196B, THR250A, THR254A, THR25B, THR261A, THR264A, THR268A, THR26B, THR32B, THR95B, TRP106B, TRP114B, TRP116B, TRP135B, TRP143A, TRP166B, TRP198A, TRP202A, TRP209A, TRP213A, TRP28B, TRP56B, TRP59B, TRP65B, TRP85B, TYR110B, TYR118B, TYR162B, TYR190A, TYR196A, TYR212A, TYR223A, TYR258A, VAL104A, VAL106A, VAL124B, VAL130B, VAL131B, VAL151A, VAL177A, VAL185A, VAL189B, VAL194B, VAL23B, VAL242A, VAL246A, VAL248B, VAL249A, VAL260A, VAL57B, VAL98B
• A-C: ALA147A, ALA55C, ALA98A, ARG138C, ARG139A, ARG142A, ARG387A, ARG48C, ARG50A, ASN150A, ASN97A, ASP139C, ASP141C, ASP390A, ASP52C, CB6.71682-25.56338, CB8.89019-5.15285, GLN148A, GLN43C, GLN45A, GLU100A, GLU386A, GLU42A, GLY102A, GLY141A, GLY155A, GLY159A, GLY41A, GLY99A, HIS144A, HIS146A, HIS40A, HIS40A5, ILE137C, ILE157A, ILE158A, ILE219A, ILE220A, ILE385A, LEU101C, LEU51C, LYS43A, MET134C, MET170A, PHE54C, PRO101A, PRO103A, PRO156A, PRO56C, SER44A, SER53C, THR131C, THR135C, THR140C, TRP132C, TRP143A, TRP47C, TYR352A, VAL104A, VAL108C, VAL136C
• A-D: ARG225A, GLU228A, ILE219A, ILE220A, ILE226A, LEU224A, SER227A, TYR223A, UNK510D, UNK511D, UNK512D, UNK513D, UNK514D, UNK515D, UNK516D, UNK517D, UNK518D, UNK519D, UNK520D
• A-E: ALA273E, ALA392A, ALA83A, ALA87A, ALA89A, ARG119E, ARG267E, ARG52A, ASN90A, ASP181E, ASP390A, ASP394A, ASP396A, GLN115E, GLN272E, GLN276E, GLN398A, GLN46A, GLN86A, GLU152E, GLY274E, GLY418A, GLY419A, ILE269E, ILE422A, LEU179E, LEU180E, LEU271E, LEU275E, LEU391A, LYS277E, LYS424A, LYS92E, PHE116E, PHE265E, PHE425A, PHE48A, PHE81A, PRO118E, PRO266E, PRO270E, PRO278E, PRO307A, PRO420A, PRO423A, PRO85A, PRO91A, SER120E, SER397A, SER82A, SER93E, THR268E, THR395A, TRP84A, TYR304A, TYR393A, VAL125A, VAL303A, VAL306A, VAL426A, VAL88A
• A-F: ALA175F, ALA392A, ARG387A, ARG52A, ARG62F, ASP187F, ASP390A, ASP394A, ASP396A, ASP61F, GLN174F, GLN178F, GLN181F, GLN398A, GLN46A, GLU177F, GLY180F, GLY301A, GLY302A, GLY419A, HIS179F, ILE249F, ILE422A, LEU182F, LEU391A, LYS300A, LYS424A, MET183F, PHE425A, PHE48A, PRO420A, PRO423A, SER397A, SER44A, THR176F, THR395A, TYR304A, TYR393A, VAL248F, VAL303A, VAL421A
• A-I: ALA273A, ALA392I, ALA83I, ALA87I, ALA89I, ARG119A, ARG267A, ARG52I, ASN90I, ASP181A, ASP390I, ASP394I, ASP396I, GLN115A, GLN272A, GLN276A, GLN398I, GLN46I, GLN86I, GLU152A, GLY274A, GLY418I, GLY419I, ILE269A, ILE422I, LEU179A, LEU180A, LEU271A, LEU275A, LEU279A, LEU391I, LEU49I, LYS277A, LYS424I, LYS92A, PHE116A, PHE425I, PHE48I, PHE81I, PRO118A, PRO266A, PRO270A, PRO278A, PRO307I, PRO420I, PRO423I, PRO85I, PRO91I, SER120A, SER397I, SER82I, SER93A, THR268A, THR395I, TRP84I, TYR304I, TYR393I, VAL121A, VAL125I, VAL303I, VAL306I, VAL426I, VAL88I
• B-C: ALA115C, ALA117C, ALA122C, ALA161C, ALA164C, ALA168C, ALA176C, ALA19B, ALA221B, ALA222B, ALA37B, ALA96C, ARG102C, ARG109B, ARG138C, ARG195B, ARG203B, ARG207B, ARG211B, ARG22C, ARG39C, ARG98C, ASN108B, ASN112B, ASN32C, ASP129C, ASP139C, ASP141C, ASP20C, ASP27B, ASP52B, ASP54B, ASP58B, CYS111B, CYS22B, GLN128C, GLN43C, GLU100C, GLU105B, GLU109C, GLU127C, GLU149C, GLU18B, GLU200B, GLU206B, GLU216B, GLU42C, GLU73C, GLU99C, GLY100B, GLY104B, GLY115B, GLY121C, GLY130C, GLY163C, GLY214B, GLY21B, GLY23C, GLY40B, GLY41B, GLY46C, GLY50C, GLY77C, HIS104C, HIS133C, HIS146C, HIS14B, HIS43B, HIS45B, ILE103B, ILE107B, ILE118C, ILE137C, ILE147C, ILE148C, ILE156C, ILE159C, ILE18C, ILE202B, ILE40C, ILE44B, ILE44C, LEU101B, LEU101C, LEU102B, LEU107C, LEU111C, LEU123B, LEU210B, LEU21C, LEU31B, LEU33B, LEU34B, LEU36B, LEU39B, LEU48B, LEU51C, LEU74C, LYS169C, LYS215B, MET134C, MET152C, MET160C, MET198B, MET204B, MET24C, MET29B, MET47B, PHE113B, PHE119B, PHE124C, PHE125C, PHE13B, PHE150C, PHE165C, PHE166C, PHE175C, PHE213B, PHE223B, PHE224B, PHE30B, PHE35B, PHE46B, PHE55B, PRO126B, PRO12B, PRO144C, PRO155C, PRO173C, PRO199B, PRO219B, PRO97C, SER123C, SER145C, SER153C, SER158C, SER15B, SER197B, THR117B, THR126C, THR131C, THR135C, THR140C, THR143C, THR196B, THR209B, THR212B, THR25B, THR26B, THR32B, TRP106B, TRP110C, TRP114B, TRP116B, TRP120C, TRP132C, TRP28B, TRP47C, TRP56B, TRP59B, TRP62C, TYR110B, TYR114C, TYR118B, TYR119C, TYR151C, TYR154C, TYR157C, TYR174C, TYR201B, TYR35C, TYR41C, TYR42B, TYR45C, VAL105C, VAL106C, VAL108C, VAL112C, VAL113C, VAL116C, VAL124B, VAL136C, VAL162C, VAL194B, VAL19C, VAL205B, VAL217B, VAL218B, VAL220B, VAL23B, VAL28C, VAL38B, VAL38C
• B-D: ALA37B, ALA79B, ALA80B, ARG207B, ARG211B, ASN87B, CYS22B, GLU206B, GLU216B, GLY208B, GLY214B, GLY226B, GLY40B, GLY41B, HIS45B, ILE44B, LEU210B, LEU33B, LEU34B, LEU39B, LYS215B, PHE13B, PHE213B, PHE223B, PHE224B, PHE227B, PHE30B, PHE76B, PHE83B, PHE84B, PHE88B, PRO12B, PRO219B, SER225B, SER229B, THR209B, THR212B, THR26B, THR75B, TYR42B, UNK501D, UNK502D, UNK503D, UNK504D, UNK505D, UNK506D, UNK507D, UNK508D, UNK509D, UNK510D, UNK511D, UNK512D, UNK513D, UNK514D, UNK515D, UNK516D, UNK517D, UNK518D, UNK519D, UNK520D, VAL217B, VAL218B, VAL220B, VAL228B, VAL23B, VAL38B
• B-F: ALA150F, ARG203B, ARG207B, ARG211B, ARG63F, GLU200B, GLU206B, GLU216B, GLY208B, GLY214B, GLY240F, ILE148F, ILE202B, LEU155F, LEU159F, LEU210B, LYS215B, LYS241F, LYS247F, MET204B, MET230F, PHE213B, PHE238F, SER145F, SER154F, SER244F, THR209B, THR212B, THR245F, THR246F, TRP236F, TRP237F, TRP242F, TYR146F, TYR201B, TYR233F, TYR243F, VAL147F, VAL151F, VAL152F, VAL205B, VAL217B, VAL239F
• B-I: ALA175B, ALA392I, ARG387I, ARG52I, ARG62B, ASP187B, ASP390I, ASP394I, ASP396I, ASP61B, GLN174B, GLN178B, GLN181B, GLN398I, GLN46I, GLU177B, GLY180B, GLY301I, GLY302I, GLY419I, HIS179B, ILE249B, ILE422I, LEU182B, LEU299I, LEU391I, LYS300I, LYS424I, MET183B, PHE425I, PHE48I, PRO420I, PRO423I, SER397I, SER44I, THR176B, THR395I, TYR304I, TYR393I, VAL248B, VAL303I, VAL421I
• B-J: ALA150B, ARG203J, ARG207J, ARG211J, ARG63B, GLU200J, GLU206J, GLU216J, GLY208J, GLY214J, GLY240B, ILE148B, ILE202J, LEU155B, LEU159B, LEU210J, LYS215J, LYS241B, LYS247B, MET204J, MET230B, PHE213J, PHE238B, SER145B, SER154B, SER244B, THR209J, THR212J, THR245B, THR246B, THR67B, TRP236B, TRP237B, TRP242B, TYR146B, TYR201J, TYR233B, TYR243B, VAL147B, VAL151B, VAL152B, VAL205J, VAL217J, VAL239B
• B-K: ARG138K, ASP141K, ILE249B, PHE142K, PHE150K, THR140K, THR246B, TYR151K, TYR243B
• C-D: ALA115C, ALA122C, ALA161C, ALA164C, ALA168C, GLU100C, HIS104C, ILE118C, ILE172C, LEU101C, LEU107C, LEU111C, PHE165C, PHE175C, PRO173C, PRO97C, TYR114C, TYR157C, TYR174C, UNK502D, UNK503D, UNK504D, UNK505D, UNK506D, UNK507D, UNK508D, UNK509D, UNK510D, UNK511D, UNK512D, UNK513D, UNK514D, UNK515D, UNK516D, UNK517D, UNK518D, UNK519D, UNK520D, VAL105C, VAL108C
• C-M: ALA49C, ALA79C, ARG171C, ARG22C, ASP20C, GLN59C, GLU42C, GLU57C, GLU69C, GLU73C, GLY23C, GLY27C, GLY30C, ILE156C, ILE159C, ILE33C, ILE37C, ILE40C, ILE44C, ILE65C, LEU31C, LEU63C, LEU66C, LEU72C, LEU80C, LEU84C, MET152C, PHE34C, PHE58C, PRO71C, SER64C, SER76C, THR60C, THR68C, THR87C, TRP110C, TRP25C, TRP62C, TRP67C, TRP83C, TYR167C, TYR35C, TYR41C, TYR45C, TYR61C, UNK10M, UNK11M, UNK12M, UNK13M, UNK14M, UNK15M, UNK16M, UNK17M, UNK18M, UNK19M, UNK1M, UNK20M, UNK21M, UNK22M, UNK23M, UNK24M, UNK25M, UNK26M, UNK2M, UNK3M, UNK4M, UNK5M, UNK6M, UNK7M, UNK8M, UNK9M, VAL106C, VAL26C, VAL38C, VAL75C
• C-F: ARG138C, ASP141C, ILE249F, PHE142C, PHE150C, THR140C, THR246F, TYR151C, TYR243F
• E-F: ALA109E, ALA117E, ALA128F, ALA133F, ALA140E, ALA168F, ALA170F, ALA171F, ALA175F, ALA186F, ALA197E, ALA19F, ALA205E, ALA206E, ALA207E, ALA208E, ALA20F, ALA221E, ALA244E, ALA248E, ALA253E, ALA259E, ALA273E, ALA94F, ALA98E, ARG107E, ARG109F, ARG119E, ARG138E, ARG139E, ARG194E, ARG195F, ARG225E, ARG240E, ARG241E, ARG267E, ARG62F, ARG63F, ASN150E, ASN164F, ASN165F, ASN262E, ASN87F, ASN97E, ASP134E, ASP137F, ASP175E, ASP181E, ASP186E, ASP187F, ASP193E, ASP231E, ASP237E, ASP238E, ASP239E, ASP27F, ASP54F, ASP58F, ASP61F, CYS111F, CYS22F, GLN110E, GLN115E, GLN148E, GLN174F, GLN178F, GLN181F, GLN234E, GLN272E, GLN276E, GLU100E, GLU105F, GLU152E, GLU177F, GLU188E, GLU232E, GLU233E, GLU86F, GLY100F, GLY102E, GLY104F, GLY115F, GLY141E, GLY144F, GLY153F, GLY154E, GLY155E, GLY156F, GLY180F, GLY182E, GLY190F, GLY191E, GLY218E, GLY236E, GLY243E, GLY257E, GLY93F, GLY99E, HIS173F, HIS179F, HIS192F, HIS199E, HIS40E, ILE103F, ILE107F, ILE112E, ILE121F, ILE133E, ILE138F, ILE139F, ILE158E, ILE169F, ILE192E, ILE195E, ILE204E, ILE210E, ILE219E, ILE220E, ILE226E, ILE235E, ILE245E, ILE249F, ILE251E, ILE255E, ILE256E, ILE269E, LEU101F, LEU102F, LEU105E, LEU123F, LEU129F, LEU134F, LEU135E, LEU136F, LEU141F, LEU142F, LEU160F, LEU172F, LEU179E, LEU180E, LEU182F, LEU185F, LEU187E, LEU188F, LEU211E, LEU224E, LEU247E, LEU271E, LEU275E, LEU31F, LEU33F, LEU34F, LEU90F, LEU96E, LYS136E, LYS174E, LYS216E, LYS217E, LYS230E, LYS247F, LYS24F, LYS60F, LYS89F, MET140F, MET170E, MET183F, MET198F, MET203E, MET29F, PHE111E, PHE113F, PHE116E, PHE119F, PHE125F, PHE13F, PHE161F, PHE173E, PHE191F, PHE193F, PHE200E, PHE214E, PHE215E, PHE224F, PHE265E, PHE30F, PHE35F, PHE83F, PHE84F, PHE88F, PHE92F, PHE95E, PHE96F, PRO101E, PRO103E, PRO118E, PRO120F, PRO126F, PRO132F, PRO156E, PRO163F, PRO167F, PRO176E, PRO199F, PRO201E, PRO266E, PRO270E, PRO91F, SER122F, SER127F, SER143F, SER184F, SER197F, SER222E, SER227E, SER263E, SER99F, THR108E, THR117F, THR176F, THR178E, THR183E, THR189E, THR196F, THR250E, THR254E, THR25F, THR261E, THR264E, THR268E, THR26F, THR32F, THR95F, TRP106F, TRP114F, TRP116F, TRP135F, TRP143E, TRP166F, TRP198E, TRP202E, TRP209E, TRP213E, TRP28F, TRP56F, TRP59F, TRP65F, TRP85F, TYR110F, TYR118F, TYR162F, TYR190E, TYR196E, TYR212E, TYR223E, TYR258E, VAL104E, VAL106E, VAL124F, VAL130F, VAL131F, VAL151E, VAL177E, VAL185E, VAL189F, VAL194F, VAL23F, VAL242E, VAL246E, VAL248F, VAL249E, VAL260E, VAL57F, VAL98F
• E-G: ALA147E, ALA55G, ALA98E, ARG138G, ARG139E, ARG142E, ARG387E, ARG48G, ARG50E, ASN150E, ASN97E, ASP139G, ASP390E, ASP52G, GLN148E, GLN43G, GLN45E, GLU100E, GLU386E, GLU42E, GLY102E, GLY141E, GLY155E, GLY159E, GLY41E, GLY99E, HIS144E, HIS146E, HIS40E, ILE137G, ILE157E, ILE158E, ILE219E, ILE220E, ILE385E, LEU101G, LEU51G, LYS43E, MET134G, MET170E, PHE54G, PRO101E, PRO103E, PRO156E, PRO56G, SER44E, SER53G, THR131G, THR135G, THR140G, TRP132G, TRP143E, TRP47G, TYR352E, VAL104E, VAL108G, VAL136G
• E-H: ARG225E, GLU228E, ILE219E, ILE220E, ILE226E, LEU224E, SER227E, TYR223E, UNK510H, UNK511H, UNK512H, UNK513H, UNK514H, UNK515H, UNK516H, UNK517H, UNK518H, UNK519H, UNK520H
• E-I: ALA273I, ALA392E, ALA83E, ALA87E, ALA89E, ARG119I, ARG267I, ARG52E, ASN90E, ASP181I, ASP390E, ASP394E, ASP396E, GLN115I, GLN272I, GLN276I, GLN398E, GLN46E, GLN86E, GLU152I, GLY274I, GLY418E, GLY419E, ILE269I, ILE422E, LEU179I, LEU180I, LEU271I, LEU275I, LEU391E, LEU49E, LYS277I, LYS424E, LYS92I, PHE116I, PHE265I, PHE425E, PHE48E, PHE81E, PRO118I, PRO266I, PRO270I, PRO278I, PRO307E, PRO420E, PRO423E, PRO85E, PRO91E, SER120I, SER397E, SER82E, SER93I, THR268I, THR395E, TRP84E, TYR304E, TYR393E, VAL125E, VAL303E, VAL306E, VAL426E, VAL88E
• E-J: ALA175J, ALA392E, ARG387E, ARG52E, ARG62J, ASP187J, ASP390E, ASP394E, ASP396E, ASP61J, GLN174J, GLN178J, GLN181J, GLN398E, GLN46E, GLU177J, GLY180J, GLY301E, GLY302E, GLY419E, HIS179J, ILE249J, ILE422E, LEU182J, LEU299E, LEU391E, LYS300E, LYS424E, MET183J, PHE425E, PHE48E, PRO420E, PRO423E, SER397E, SER44E, THR176J, THR395E, TYR304E, TYR393E, VAL248J, VAL303E, VAL421E
• F-G: ALA115G, ALA117G, ALA122G, ALA161G, ALA164G, ALA168G, ALA176G, ALA19F, ALA221F, ALA222F, ALA37F, ALA96G, ARG102G, ARG109F, ARG138G, ARG195F, ARG203F, ARG207F, ARG211F, ARG22G, ARG39G, ARG98G, ASN108F, ASN112F, ASN32G, ASP129G, ASP139G, ASP141G, ASP20G, ASP27F, ASP52F, ASP54F, ASP58F, CYS111F, CYS22F, GLN128G, GLN43G, GLU100G, GLU105F, GLU109G, GLU127G, GLU149G, GLU18F, GLU200F, GLU206F, GLU216F, GLU42G, GLU73G, GLU99G, GLY100F, GLY104F, GLY115F, GLY121G, GLY130G, GLY163G, GLY214F, GLY21F, GLY23G, GLY40F, GLY41F, GLY46G, GLY50G, GLY77G, HIS104G, HIS133G, HIS146G, HIS14F, HIS43F, HIS45F, ILE103F, ILE107F, ILE118G, ILE137G, ILE147G, ILE148G, ILE156G, ILE159G, ILE18G, ILE202F, ILE40G, ILE44F, ILE44G, LEU101F, LEU101G, LEU102F, LEU107G, LEU111G, LEU123F, LEU210F, LEU21G, LEU31F, LEU33F, LEU34F, LEU36F, LEU39F, LEU48F, LEU51G, LEU74G, LYS169G, LYS215F, MET134G, MET152G, MET160G, MET198F, MET204F, MET24G, MET29F, MET47F, PHE113F, PHE119F, PHE124G, PHE125G, PHE13F, PHE150G, PHE165G, PHE166G, PHE175G, PHE213F, PHE223F, PHE224F, PHE30F, PHE35F, PHE46F, PHE55F, PRO126F, PRO12F, PRO144G, PRO155G, PRO173G, PRO199F, PRO219F, PRO97G, SER123G, SER145G, SER153G, SER158G, SER15F, SER197F, THR117F, THR126G, THR131G, THR135G, THR140G, THR143G, THR196F, THR209F, THR212F, THR25F, THR26F, THR32F, TRP106F, TRP110G, TRP114F, TRP116F, TRP120G, TRP132G, TRP28F, TRP47G, TRP56F, TRP59F, TRP62G, TYR110F, TYR114G, TYR118F, TYR119G, TYR151G, TYR154G, TYR157G, TYR174G, TYR201F, TYR35G, TYR41G, TYR42F, TYR45G, VAL105G, VAL106G, VAL108G, VAL112G, VAL113G, VAL116G, VAL124F, VAL136G, VAL162G, VAL194F, VAL19G, VAL205F, VAL217F, VAL218F, VAL220F, VAL23F, VAL28G, VAL38F, VAL38G
• F-H: ALA37F, ALA79F, ALA80F, ARG207F, ARG211F, ASN87F, CYS22F, GLU206F, GLU216F, GLY208F, GLY214F, GLY226F, GLY40F, GLY41F, HIS45F, ILE44F, LEU210F, LEU33F, LEU34F, LEU39F, LYS215F, PHE13F, PHE213F, PHE223F, PHE224F, PHE227F, PHE30F, PHE76F, PHE83F, PHE84F, PHE88F, PRO12F, PRO219F, SER225F, SER229F, THR209F, THR212F, THR26F, THR75F, TYR42F, UNK501H, UNK502H, UNK503H, UNK504H, UNK505H, UNK506H, UNK507H, UNK508H, UNK509H, UNK510H, UNK511H, UNK512H, UNK513H, UNK514H, UNK515H, UNK516H, UNK517H, UNK518H, UNK519H, UNK520H, VAL217F, VAL218F, VAL220F, VAL228F, VAL23F, VAL38F
• F-J: ALA150J, ARG203F, ARG207F, ARG211F, ARG63J, GLU200F, GLU206F, GLU216F, GLY208F, GLY214F, GLY240J, ILE148J, ILE202F, LEU155J, LEU159J, LEU210F, LYS215F, LYS241J, LYS247J, MET204F, MET230J, PHE213F, PHE227F, PHE238J, SER145J, SER154J, SER244J, THR209F, THR212F, THR245J, THR246J, THR67J, TRP236J, TRP237J, TRP242J, TYR146J, TYR201F, TYR233J, TYR243J, VAL147J, VAL151J, VAL152J, VAL205F, VAL217F, VAL239J
• G-H: ALA115G, ALA122G, ALA161G, ALA164G, ALA168G, GLU100G, HIS104G, ILE118G, ILE172G, LEU101G, LEU107G, LEU111G, PHE165G, PHE175G, PRO173G, PRO97G, TYR114G, TYR157G, TYR174G, UNK502H, UNK503H, UNK504H, UNK505H, UNK506H, UNK507H, UNK508H, UNK509H, UNK510H, UNK511H, UNK512H, UNK513H, UNK514H, UNK515H, UNK516H, UNK517H, UNK518H, UNK519H, UNK520H, VAL105G, VAL108G
• G-N: ALA49G, ALA79G, ARG102G, ARG171G, ARG22G, ASP20G, GLN59G, GLU42G, GLU57G, GLU69G, GLU73G, GLY23G, GLY27G, GLY30G, ILE156G, ILE159G, ILE33G, ILE37G, ILE40G, ILE44G, ILE65G, LEU31G, LEU63G, LEU66G, LEU72G, LEU80G, LEU84G, MET152G, PHE34G, PHE58G, PRO71G, SER64G, SER76G, THR60G, THR68G, THR87G, TRP110G, TRP25G, TRP62G, TRP67G, TRP83G, TYR167G, TYR35G, TYR41G, TYR45G, TYR61G, UNK10N, UNK11N, UNK12N, UNK13N, UNK14N, UNK15N, UNK16N, UNK17N, UNK18N, UNK19N, UNK1N, UNK20N, UNK21N, UNK22N, UNK23N, UNK24N, UNK25N, UNK26N, UNK2N, UNK3N, UNK4N, UNK5N, UNK6N, UNK7N, UNK8N, UNK9N, VAL106G, VAL26G, VAL38G, VAL75G
• G-J: ARG138G, ASP141G, ILE249J, PHE142G, PHE150G, THR140G, THR246J, TYR151G, TYR243J
• I-J: ALA109I, ALA117I, ALA128J, ALA133J, ALA140I, ALA168J, ALA170J, ALA171J, ALA175J, ALA186J, ALA197I, ALA19J, ALA205I, ALA206I, ALA207I, ALA208I, ALA20J, ALA221I, ALA244I, ALA248I, ALA253I, ALA259I, ALA273I, ALA94J, ALA98I, ARG107I, ARG109J, ARG119I, ARG138I, ARG139I, ARG194I, ARG195J, ARG225I, ARG240I, ARG241I, ARG267I, ARG62J, ARG63J, ASN150I, ASN164J, ASN165J, ASN262I, ASN87J, ASN97I, ASP134I, ASP137J, ASP175I, ASP181I, ASP186I, ASP187J, ASP193I, ASP231I, ASP237I, ASP238I, ASP239I, ASP27J, ASP54J, ASP58J, ASP61J, CYS22J, GLN110I, GLN115I, GLN148I, GLN174J, GLN178J, GLN181J, GLN234I, GLN272I, GLN276I, GLU100I, GLU105J, GLU152I, GLU177J, GLU188I, GLU232I, GLU233I, GLU86J, GLY100J, GLY102I, GLY104J, GLY115J, GLY141I, GLY144J, GLY153J, GLY154I, GLY155I, GLY156J, GLY180J, GLY182I, GLY190J, GLY191I, GLY218I, GLY236I, GLY243I, GLY257I, GLY93J, GLY99I, HIS173J, HIS179J, HIS192J, HIS199I, HIS40I, ILE103J, ILE107J, ILE112I, ILE121J, ILE133I, ILE138J, ILE139J, ILE158I, ILE169J, ILE192I, ILE195I, ILE204I, ILE210I, ILE219I, ILE220I, ILE226I, ILE235I, ILE245I, ILE249J, ILE251I, ILE255I, ILE256I, ILE269I, LEU101J, LEU102J, LEU105I, LEU123J, LEU129J, LEU134J, LEU135I, LEU136J, LEU141J, LEU142J, LEU160J, LEU172J, LEU179I, LEU180I, LEU182J, LEU185J, LEU187I, LEU188J, LEU211I, LEU224I, LEU247I, LEU271I, LEU275I, LEU31J, LEU33J, LEU34J, LEU90J, LEU96I, LYS136I, LYS174I, LYS216I, LYS217I, LYS230I, LYS247J, LYS24J, LYS60J, LYS89J, MET140J, MET170I, MET183J, MET198J, MET203I, MET29J, PHE111I, PHE113J, PHE116I, PHE119J, PHE125J, PHE13J, PHE161J, PHE173I, PHE191J, PHE193J, PHE200I, PHE214I, PHE215I, PHE224J, PHE265I, PHE30J, PHE35J, PHE83J, PHE84J, PHE88J, PHE92J, PHE95I, PHE96J, PRO101I, PRO103I, PRO118I, PRO120J, PRO126J, PRO132J, PRO156I, PRO163J, PRO167J, PRO176I, PRO199J, PRO201I, PRO266I, PRO270I, PRO91J, SER122J, SER127J, SER143J, SER184J, SER197J, SER222I, SER227I, SER263I, SER99J, THR108I, THR117J, THR176J, THR178I, THR183I, THR189I, THR196J, THR250I, THR254I, THR25J, THR261I, THR264I, THR268I, THR26J, THR32J, THR95J, TRP106J, TRP114J, TRP116J, TRP135J, TRP143I, TRP166J, TRP198I, TRP202I, TRP209I, TRP213I, TRP28J, TRP56J, TRP59J, TRP65J, TRP85J, TYR110J, TYR118J, TYR162J, TYR190I, TYR196I, TYR212I, TYR223I, TYR258I, VAL104I, VAL106I, VAL124J, VAL130J, VAL131J, VAL151I, VAL177I, VAL185I, VAL189J, VAL194J, VAL23J, VAL242I, VAL246I, VAL248J, VAL249I, VAL260I, VAL57J, VAL98J
• I-K: ALA147I, ALA55K, ALA98I, ARG138K, ARG139I, ARG142I, ARG387I, ARG48K, ARG50I, ASN150I, ASN97I, ASP139K, ASP390I, ASP52K, GLN148I, GLN43K, GLN45I, GLU100I, GLU386I, GLU42I, GLY102I, GLY141I, GLY155I, GLY159I, GLY41I, GLY99I, HIS144I, HIS146I, HIS40I, ILE137K, ILE157I, ILE158I, ILE219I, ILE220I, ILE385I, LEU101K, LEU51K, LYS43I, MET134K, MET170I, PHE54K, PRO101I, PRO103I, PRO156I, PRO56K, SER44I, SER53K, THR131K, THR135K, THR140K, TRP132K, TRP143I, TRP47K, TYR352I, VAL104I, VAL108K, VAL136K
• I-L: ARG225I, GLU228I, ILE219I, ILE220I, ILE226I, LEU224I, SER227I, TYR223I, UNK510L, UNK511L, UNK512L, UNK513L, UNK514L, UNK515L, UNK516L, UNK517L, UNK518L, UNK519L, UNK520L
• J-K: ALA115K, ALA117K, ALA122K, ALA161K, ALA164K, ALA168K, ALA176K, ALA19J, ALA221J, ALA222J, ALA37J, ALA96K, ARG102K, ARG109J, ARG138K, ARG195J, ARG203J, ARG207J, ARG211J, ARG22K, ARG39K, ARG98K, ASN108J, ASN112J, ASN32K, ASP129K, ASP139K, ASP141K, ASP20K, ASP27J, ASP52J, ASP54J, ASP58J, CYS111J, CYS22J, GLN128K, GLN43K, GLU100K, GLU105J, GLU109K, GLU127K, GLU149K, GLU18J, GLU200J, GLU206J, GLU216J, GLU42K, GLU73K, GLU99K, GLY100J, GLY104J, GLY115J, GLY121K, GLY130K, GLY163K, GLY214J, GLY21J, GLY23K, GLY40J, GLY41J, GLY46K, GLY50K, GLY77K, HIS104K, HIS133K, HIS146K, HIS14J, HIS43J, HIS45J, ILE103J, ILE107J, ILE118K, ILE137K, ILE147K, ILE148K, ILE156K, ILE159K, ILE18K, ILE202J, ILE40K, ILE44J, ILE44K, LEU101J, LEU101K, LEU102J, LEU107K, LEU111K, LEU123J, LEU210J, LEU21K, LEU31J, LEU33J, LEU34J, LEU36J, LEU39J, LEU48J, LEU51K, LEU74K, LYS169K, LYS215J, MET134K, MET152K, MET160K, MET198J, MET204J, MET24K, MET29J, MET47J, PHE113J, PHE119J, PHE124K, PHE125K, PHE13J, PHE150K, PHE165K, PHE166K, PHE175K, PHE213J, PHE223J, PHE224J, PHE30J, PHE35J, PHE46J, PHE55J, PRO126J, PRO12J, PRO144K, PRO155K, PRO173K, PRO199J, PRO219J, PRO97K, SER123K, SER145K, SER153K, SER158K, SER15J, SER197J, THR117J, THR126K, THR131K, THR135K, THR140K, THR143K, THR196J, THR209J, THR212J, THR25J, THR26J, THR32J, TRP106J, TRP110K, TRP114J, TRP116J, TRP120K, TRP132K, TRP28J, TRP47K, TRP56J, TRP59J, TRP62K, TYR110J, TYR114K, TYR118J, TYR119K, TYR151K, TYR154K, TYR157K, TYR174K, TYR201J, TYR35K, TYR41K, TYR42J, TYR45K, VAL105K, VAL106K, VAL108K, VAL112K, VAL113K, VAL116K, VAL124J, VAL136K, VAL162K, VAL194J, VAL19K, VAL205J, VAL217J, VAL218J, VAL220J, VAL23J, VAL28K, VAL38J, VAL38K
• J-L: ALA37J, ALA79J, ALA80J, ARG207J, ARG211J, ASN87J, CYS22J, GLU206J, GLU216J, GLY208J, GLY214J, GLY226J, GLY40J, GLY41J, HIS45J, ILE44J, LEU210J, LEU33J, LEU34J, LEU39J, LYS215J, PHE13J, PHE213J, PHE223J, PHE224J, PHE227J, PHE30J, PHE76J, PHE83J, PHE84J, PHE88J, PRO12J, PRO219J, SER225J, SER229J, THR209J, THR212J, THR26J, THR75J, TYR42J, UNK501L, UNK502L, UNK503L, UNK504L, UNK505L, UNK506L, UNK507L, UNK508L, UNK509L, UNK510L, UNK511L, UNK512L, UNK513L, UNK514L, UNK515L, UNK516L, UNK517L, UNK518L, UNK519L, UNK520L, VAL217J, VAL218J, VAL220J, VAL228J, VAL23J, VAL38J
• K-L: ALA115K, ALA122K, ALA161K, ALA164K, ALA168K, GLU100K, HIS104K, ILE118K, ILE172K, LEU101K, LEU107K, LEU111K, PHE165K, PHE175K, PRO173K, PRO97K, TYR114K, TYR157K, TYR174K, UNK502L, UNK503L, UNK504L, UNK505L, UNK506L, UNK507L, UNK508L, UNK509L, UNK510L, UNK511L, UNK512L, UNK513L, UNK514L, UNK515L, UNK516L, UNK517L, UNK518L, UNK519L, UNK520L, VAL105K, VAL108K
• K-O: ALA49K, ALA79K, ARG171K, ARG22K, ASP20K, GLN59K, GLU42K, GLU57K, GLU69K, GLU73K, GLY23K, GLY27K, GLY30K, ILE156K, ILE159K, ILE33K, ILE37K, ILE40K, ILE44K, ILE65K, LEU31K, LEU63K, LEU66K, LEU72K, LEU80K, LEU84K, MET152K, PHE34K, PHE58K, PRO71K, SER64K, SER76K, THR60K, THR68K, THR87K, TRP110K, TRP25K, TRP62K, TRP67K, TRP83K, TYR167K, TYR35K, TYR41K, TYR45K, TYR61K, UNK10O, UNK11O, UNK12O, UNK13O, UNK14O, UNK15O, UNK16O, UNK17O, UNK18O, UNK19O, UNK1O, UNK20O, UNK21O, UNK22O, UNK23O, UNK24O, UNK25O, UNK26O, UNK2O, UNK3O, UNK4O, UNK5O, UNK6O, UNK7O, UNK8O, UNK9O, VAL106K, VAL26K, VAL38K, VAL75K