3C5Y

crystal structure of a putative ribose 5-phosphate isomerase (saro_3514) from novosphingobium aromaticivorans dsm at 1.81 a resolution

• Total interactions analyzed: 120
• Total true interactions: 40
• Strongest Interaction:
  • Chains: E-P
  • Int. Res.: 8
  • Norm. En. per Res.: -5.7907
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-57.3215	-29.1152	-371.739	-458.1757	166	10	29	17556	7	30	18
A-C	-36.4384	-12.4693	-135.069	-183.9767	53	6	8	5450	4	14	17
A-D	-6.2077	0.0	-80.9153	-87.123	37	1	0	3107	0	6	2
A-G	0.0	0.0	-0.0786	-0.0786	8	0	0	53	0	8	6
A-H	-2.2147	0.0	-24.4192	-26.6339	29	0	0	1486	0	10	5
A-J	0.0	9.2276	-0.8491	8.3785	9	0	0	154	0	6	5
B-C	0.0	0.0	-86.3812	-86.3812	39	2	0	3201	0	6	2
B-D	-31.8756	-12.1687	-112.656	-156.7003	52	3	5	4937	4	12	17
B-G	0.0	0.0	-25.3446	-25.3446	31	0	0	1572	0	10	6
B-H	0.0	0.0	-0.064	-0.064	6	0	0	27	0	6	4
B-J	-10.9568	-10.9527	-8.9183	-30.8278	12	0	0	451	2	11	14
C-D	-64.9744	-29.0916	-384.512	-478.578	167	18	29	17966	6	30	18
C-K	0.0	-23.121	-14.7579	-37.8789	19	0	0	755	0	13	14
E-F	-61.091	-23.7176	-385.171	-469.9796	169	12	28	18126	6	30	18
E-G	-33.3592	-9.8632	-137.027	-180.2494	54	6	8	5525	4	12	16
E-H	0.0	0.0	-91.4577	-91.4577	38	1	0	3237	0	6	2
E-M	-13.4357	-17.0499	-39.2728	-69.7584	24	5	0	1637	1	10	13
E-P	-4.7922	-30.8523	-10.681	-46.3254	8	1	0	329	2	6	8
F-G	0.0	0.0	-90.4837	-90.4837	38	1	0	3147	0	6	2
F-H	-34.3261	-9.567	-122.614	-166.5071	50	5	7	5353	4	13	18
F-M	0.0	0.0	-0.8301	-0.8301	4	0	0	72	0	6	5
G-H	-69.089	-28.4835	-378.934	-476.5064	165	16	29	17985	7	30	18
G-J	0.0	-2.1043	-71.4978	-73.6021	43	1	1	2909	0	9	10
G-P	0.0	0.0	-0.6081	-0.6081	13	0	0	117	0	10	9
I-J	-60.6493	-32.2015	-379.74	-472.5907	167	14	29	17729	7	30	19
I-K	0.0	0.0	-92.2692	-92.2692	39	0	0	3262	0	6	2
I-L	-32.9987	-13.0982	-134.612	-180.7089	55	8	8	5594	4	15	18
I-O	0.0	-2.8377	-0.3188	-3.1565	10	0	0	76	0	9	7
I-P	0.0	0.0	-0.1872	-0.1872	5	0	0	40	0	0	1
J-K	-36.0806	-12.4268	-110.175	-158.6824	51	8	7	5113	4	14	18
J-L	0.0	0.0	-89.2396	-89.2396	39	0	0	3183	0	6	2
J-O	0.0	0.0	-20.046	-20.046	22	0	0	1393	0	7	7
J-P	0.0	-4.0417	-0.247	-4.2887	10	0	0	79	0	8	5
K-L	-59.2339	-24.6306	-377.074	-460.9386	166	11	28	17995	6	30	18
M-N	-51.9453	-24.9467	-382.122	-459.014	167	12	29	17616	5	30	18
M-O	-7.415	0.0	-73.4704	-80.8854	36	3	0	2890	0	6	2
M-P	-35.3943	-8.1019	-128.69	-172.1862	52	7	8	5464	4	12	18
N-O	-21.96	-12.0187	-88.5262	-122.5049	52	3	5	4307	4	12	18
N-P	-5.6031	0.0	-85.635	-91.2381	38	1	0	3218	0	6	2
O-P	-66.0116	-37.0212	-369.854	-472.8868	163	12	27	17277	6	30	19

Interface residues

• A-B: ALA110A, ALA110B, ALA12B, ALA164A, ALA164B, ALA184A, ALA184B, ALA56A, ALA81A, ALA81B, ALA82A, ALA82B, ALA84A, ALA84B, ALA99A, ALA99B, ARG147A, ARG147B, ARG152A, ARG152B, ARG155A, ARG155B, ARG159A, ARG159B, ARG167A, ARG167B, ASN106A, ASN106B, ASN109A, ASN109B, ASN154A, ASN154B, ASN52A, ASN52B, ASN83A, ASN83B, ASN9A, ASN9B, ASP107A, ASP107B, ASP163A, ASP163B, ASP168A, ASP168B, ASP177A, ASP177B, ASP95A, ASP95B, ASP98A, ASP98B, CYS166A, CYS166B, CYS90A, CYS90B, GLN11A, GLN11B, GLU160A, GLU160B, GLU8A, GLU8B, GLY108A, GLY108B, GLY118A, GLY118B, GLY156A, GLY156B, GLY53A, GLY53B, GLY57A, GLY57B, GLY73A, GLY73B, GLY75A, GLY75B, GLY77A, GLY77B, GLY91A, GLY91B, ILE105A, ILE105B, ILE111A, ILE111B, ILE150A, ILE150B, ILE157A, ILE157B, ILE94A, ILE94B, LEU101A, LEU101B, LEU158A, LEU158B, LEU161A, LEU161B, LEU173A, LEU173B, LEU180A, LEU180B, LEU181A, LEU181B, LEU47A, LEU47B, LEU54A, LEU54B, LEU55A, LEU55B, LEU80A, LEU80B, LEU92A, LEU92B, LYS117A, LYS117B, LYS153A, LYS153B, LYS162A, LYS162B, LYS174A, LYS174B, PHE100A, PHE100B, PHE102A, PHE102B, PHE89A, PHE89B, PRO114A, PRO114B, PRO144A, PRO86A, PRO86B, PRO96A, PRO96B, SER10A, SER10B, SER112A, SER112B, SER116A, SER116B, SER165A, SER165B, SER46B, SER78A, SER78B, THR171A, THR171B, THR175A, THR175B, THR48A, THR48B, THR74A, THR74B, THR97A, THR97B, TYR143A, TYR143B, TYR49A, TYR49B, VAL172A, VAL172B, VAL176A, VAL176B, VAL50A, VAL50B, VAL88A, VAL88B, VAL93A, VAL93B
• A-C: ALA122A, ALA122C, ALA123A, ALA123C, ARG132A, ARG132C, ARG145A, ARG145C, ARG147A, ARG147C, ASN126A, ASN126C, ASP129A, ASP129C, ASP95A, ASP95C, ASP98A, ASP98C, GLN104A, GLN104C, GLN128A, GLN128C, GLU124A, GLU124C, GLU146A, GLY120A, GLY120C, ILE105A, ILE105C, ILE94A, ILE94C, LEU101A, LEU101C, LEU125A, LEU125C, LEU127A, LEU127C, LYS133A, LYS133C, PHE100A, PHE100C, PRO144A, PRO144C, PRO96A, PRO96C, THR97A, THR97C, TRP121A, TRP121C, TYR143A, TYR143C, VAL130A, VAL130C
• A-D: ALA122A, ALA122D, ALA123A, ALA123D, ASN126A, ASN126D, ASP95A, GLN11A, GLN11D, GLU8D, GLY118A, GLY118D, GLY120A, GLY120D, GLY73A, GLY73D, GLY75A, GLY75D, LEU125D, LYS117A, LYS117D, LYS14A, LYS14D, PHE119A, PHE119D, PRO114A, PRO114D, SER10A, SER10D, SER116A, SER116D, THR74A, THR74D, TRP121A, TRP121D, TYR115A, TYR115D
• A-G: ALA164A, ALA164G, ARG167A, ARG167G, GLU160A, LYS174A, LYS174G, THR171G
• A-H: ARG167A, ARG167H, ARG182A, ARG182H, ASP168A, ASP168H, ASP177A, ASP177H, GLN178A, GLN178H, LEU170A, LEU170H, LEU173A, LEU173H, LEU210A, LYS174A, LYS174H, SER209A, SER209H, THR171A, THR171H, THR175A, THR175H, TYR206A, TYR206H, VAL172A, VAL172H, VAL176A, VAL176H
• A-J: GLU149A, GLU20J, GLU27J, HIS19J, ILE150A, LYS153A, PRO28J, THR23J, THR24J
• B-C: ALA122B, ALA122C, ALA123B, ALA123C, ASN126B, ASN126C, ASP95C, GLN11B, GLN11C, GLU8B, GLU8C, GLY118B, GLY118C, GLY120B, GLY120C, GLY73B, GLY73C, GLY75B, GLY75C, LEU125B, LYS117B, LYS117C, LYS14B, LYS14C, PHE119B, PHE119C, PRO114B, PRO114C, SER10B, SER10C, SER116B, SER116C, THR74B, THR74C, TRP121B, TRP121C, TYR115B, TYR115C, TYR49B
• B-D: ALA122B, ALA122D, ALA123B, ALA123D, ARG132B, ARG132D, ARG147B, ARG147D, ASN106D, ASN126B, ASN126D, ASP129B, ASP129D, ASP95B, ASP95D, ASP98B, ASP98D, GLN104B, GLN104D, GLN128B, GLN128D, GLU124B, GLU124D, GLU146D, GLY120B, GLY120D, ILE105B, ILE105D, ILE94B, ILE94D, LEU101B, LEU101D, LEU125B, LEU125D, LEU127B, LEU127D, LYS133B, LYS133D, PHE100B, PHE100D, PRO144B, PRO144D, PRO96B, PRO96D, THR97B, THR97D, TRP121B, TRP121D, TYR143B, TYR143D, VAL130B, VAL130D
• B-G: ARG167B, ARG167G, ARG182B, ARG182G, ASP168B, ASP168G, ASP177B, ASP177G, ASP179B, GLN178B, GLN178G, LEU170B, LEU170G, LEU173B, LEU173G, LEU210B, LEU210G, LYS174B, LYS174G, SER209B, SER209G, THR171B, THR171G, THR175B, THR175G, TYR206B, TYR206G, VAL172B, VAL172G, VAL176B, VAL176G
• B-H: ALA164B, ALA164H, ARG167B, ARG167H, LYS174B, LYS174H
• B-J: ALA13J, ALA41J, ARG182B, ASP177B, ASP179B, GLN178B, GLU188J, GLU42J, LEU180B, LYS189J, LYS44B, THR40J
• C-D: ALA110C, ALA110D, ALA12C, ALA12D, ALA164C, ALA164D, ALA184C, ALA184D, ALA81C, ALA81D, ALA82C, ALA82D, ALA84C, ALA84D, ALA99C, ALA99D, ARG147C, ARG147D, ARG152C, ARG152D, ARG155C, ARG155D, ARG159C, ARG159D, ARG167C, ARG167D, ASN106C, ASN106D, ASN109C, ASN109D, ASN154C, ASN154D, ASN52C, ASN52D, ASN83C, ASN83D, ASN9C, ASN9D, ASP107C, ASP107D, ASP163C, ASP163D, ASP168C, ASP168D, ASP177C, ASP177D, ASP95C, ASP95D, ASP98C, ASP98D, CYS166C, CYS166D, CYS90C, CYS90D, GLN11C, GLN11D, GLU160C, GLU160D, GLU8C, GLU8D, GLY108C, GLY108D, GLY118C, GLY118D, GLY156C, GLY156D, GLY53C, GLY53D, GLY57C, GLY57D, GLY73C, GLY73D, GLY75C, GLY75D, GLY77C, GLY77D, GLY87D, GLY91C, GLY91D, ILE105C, ILE105D, ILE111C, ILE111D, ILE150C, ILE150D, ILE157C, ILE157D, ILE58C, ILE94C, ILE94D, LEU101C, LEU101D, LEU158C, LEU158D, LEU161C, LEU161D, LEU173C, LEU173D, LEU180C, LEU180D, LEU181C, LEU181D, LEU47C, LEU47D, LEU54C, LEU54D, LEU55C, LEU55D, LEU80C, LEU80D, LEU92C, LEU92D, LYS117C, LYS117D, LYS153C, LYS153D, LYS162C, LYS162D, LYS174C, LYS174D, PHE100C, PHE100D, PHE102C, PHE102D, PHE89C, PHE89D, PRO114C, PRO114D, PRO144C, PRO144D, PRO86C, PRO86D, PRO96C, PRO96D, SER10C, SER10D, SER112D, SER116C, SER116D, SER165C, SER165D, SER78C, SER78D, THR171C, THR171D, THR175C, THR175D, THR48C, THR48D, THR74C, THR74D, THR97C, THR97D, TYR143C, TYR143D, TYR49C, TYR49D, VAL172C, VAL172D, VAL176C, VAL176D, VAL50C, VAL50D, VAL88C, VAL88D, VAL93C, VAL93D
• C-K: ALA13C, ALA16C, ALA41C, ARG152K, ARG155K, ARG159K, ASN154K, GLU138K, GLU149K, GLU160K, GLU20C, GLU42C, GLY156K, ILE150K, ILE157K, LYS153K, LYS44C, THR40C, TYR39C
• E-F: ALA110E, ALA110F, ALA12E, ALA12F, ALA164E, ALA164F, ALA184E, ALA81E, ALA81F, ALA82E, ALA82F, ALA84E, ALA84F, ALA99E, ALA99F, ARG147E, ARG147F, ARG152E, ARG152F, ARG155E, ARG155F, ARG159E, ARG159F, ARG167E, ARG167F, ASN106E, ASN106F, ASN109E, ASN109F, ASN154E, ASN154F, ASN52E, ASN52F, ASN83E, ASN83F, ASN9E, ASN9F, ASP107E, ASP107F, ASP163E, ASP163F, ASP168E, ASP168F, ASP177E, ASP177F, ASP95E, ASP95F, ASP98E, ASP98F, CYS166E, CYS166F, CYS90E, CYS90F, GLN104E, GLN11E, GLN11F, GLN178F, GLU160E, GLU160F, GLU8E, GLU8F, GLY108E, GLY108F, GLY118E, GLY118F, GLY156E, GLY156F, GLY53E, GLY53F, GLY57E, GLY57F, GLY73E, GLY73F, GLY75E, GLY75F, GLY77E, GLY77F, GLY91E, GLY91F, ILE105E, ILE105F, ILE111E, ILE111F, ILE150E, ILE150F, ILE157E, ILE157F, ILE58E, ILE94E, ILE94F, LEU101E, LEU101F, LEU158E, LEU158F, LEU161E, LEU161F, LEU173E, LEU173F, LEU180E, LEU180F, LEU181E, LEU181F, LEU47E, LEU47F, LEU54E, LEU54F, LEU55E, LEU55F, LEU80E, LEU80F, LEU92E, LEU92F, LYS117E, LYS117F, LYS153E, LYS153F, LYS162E, LYS162F, LYS174E, LYS174F, PHE100E, PHE100F, PHE102E, PHE102F, PHE89E, PHE89F, PRO114E, PRO114F, PRO144E, PRO144F, PRO86E, PRO86F, PRO96E, PRO96F, SER10E, SER10F, SER112E, SER112F, SER116E, SER116F, SER165E, SER165F, SER46F, SER78E, SER78F, THR171E, THR171F, THR175E, THR175F, THR48E, THR48F, THR74E, THR74F, THR97E, THR97F, TYR143E, TYR143F, TYR49E, TYR49F, VAL172E, VAL172F, VAL176E, VAL176F, VAL50E, VAL50F, VAL88E, VAL88F, VAL93E, VAL93F
• E-G: ALA122E, ALA122G, ALA123E, ALA123G, ARG132E, ARG132G, ARG145E, ARG147E, ARG147G, ASN126E, ASN126G, ASP129E, ASP129G, ASP95E, ASP95G, ASP98E, ASP98G, GLN104E, GLN104G, GLN128E, GLN128G, GLU124E, GLU124G, GLU146E, GLU146G, GLY118G, GLY120E, GLY120G, ILE105E, ILE105G, ILE94E, ILE94G, LEU101E, LEU101G, LEU125E, LEU125G, LEU127E, LEU127G, LYS133E, LYS133G, PHE100E, PHE100G, PRO144E, PRO144G, PRO96E, PRO96G, THR97E, THR97G, TRP121E, TRP121G, TYR143E, TYR143G, VAL130E, VAL130G
• E-H: ALA122E, ALA122H, ALA123E, ALA123H, ASN126E, ASN126H, ASP95E, GLN11E, GLN11H, GLU8E, GLU8H, GLY118E, GLY118H, GLY120E, GLY120H, GLY73E, GLY73H, GLY75E, GLY75H, LEU125H, LYS117E, LYS117H, LYS14E, LYS14H, PHE119E, PHE119H, PRO114E, PRO114H, SER10E, SER10H, SER116E, SER116H, THR74E, THR74H, TRP121E, TRP121H, TYR115E, TYR115H
• E-M: ALA148E, ALA21M, ALA26M, ARG152E, ARG155E, ARG159E, GLN128M, GLU146E, GLU149E, GLU20M, GLU27M, GLY156E, GLY30M, HIS19M, ILE150E, ILE157E, LEU22M, LEU29M, LYS153E, PRO28M, THR23M, THR24M, VAL25M, VAL33M
• E-P: ARG139P, ARG145E, ARG145P, GLN104P, GLU138P, GLU146E, GLY137P, LEU141P
• F-G: ALA122F, ALA122G, ALA123F, ALA123G, ASN126F, ASN126G, ASP95G, GLN11F, GLN11G, GLU8F, GLU8G, GLY118F, GLY118G, GLY120F, GLY120G, GLY73F, GLY73G, GLY75F, GLY75G, LEU125F, LYS117F, LYS117G, LYS14F, LYS14G, PHE119F, PHE119G, PRO114F, PRO114G, SER10F, SER10G, SER116F, SER116G, THR74F, THR74G, TRP121F, TRP121G, TYR115F, TYR115G
• F-H: ALA122F, ALA122H, ALA123F, ALA123H, ARG132F, ARG132H, ARG147F, ARG147H, ASN126F, ASN126H, ASP129F, ASP129H, ASP95F, ASP95H, ASP98F, ASP98H, GLN104F, GLN104H, GLN128F, GLN128H, GLU124F, GLU124H, GLU146F, GLY120F, GLY120H, ILE105F, ILE105H, ILE94F, LEU101F, LEU101H, LEU125F, LEU125H, LEU127F, LEU127H, LYS133F, LYS133H, PHE100F, PHE100H, PRO144F, PRO144H, PRO96F, PRO96H, THR97F, THR97H, TRP121F, TRP121H, TYR143F, TYR143H, VAL130F, VAL130H
• F-M: ARG182F, ASP179F, GLU192M, LYS189M
• G-H: ALA110G, ALA110H, ALA12G, ALA12H, ALA164G, ALA164H, ALA184H, ALA81G, ALA81H, ALA82G, ALA82H, ALA84G, ALA84H, ALA99G, ALA99H, ARG147G, ARG147H, ARG152G, ARG152H, ARG155G, ARG155H, ARG159G, ARG159H, ARG167G, ARG167H, ASN106G, ASN106H, ASN109G, ASN109H, ASN154G, ASN154H, ASN52G, ASN52H, ASN83G, ASN83H, ASN9G, ASN9H, ASP107G, ASP107H, ASP163G, ASP163H, ASP168G, ASP168H, ASP177G, ASP177H, ASP95G, ASP95H, ASP98G, ASP98H, CYS166G, CYS166H, CYS90G, CYS90H, GLN11G, GLN11H, GLU160G, GLU160H, GLU8G, GLU8H, GLY108G, GLY108H, GLY118G, GLY118H, GLY156G, GLY156H, GLY53G, GLY53H, GLY57G, GLY57H, GLY73G, GLY73H, GLY75G, GLY75H, GLY77G, GLY77H, GLY91G, GLY91H, ILE105G, ILE105H, ILE111G, ILE111H, ILE150G, ILE150H, ILE157G, ILE157H, ILE94G, ILE94H, LEU101G, LEU101H, LEU158G, LEU158H, LEU161G, LEU161H, LEU173G, LEU173H, LEU180G, LEU180H, LEU181G, LEU181H, LEU47G, LEU47H, LEU54G, LEU54H, LEU55G, LEU55H, LEU80G, LEU80H, LEU92G, LEU92H, LYS117G, LYS117H, LYS153G, LYS153H, LYS162G, LYS162H, LYS174G, LYS174H, PHE100G, PHE100H, PHE102G, PHE102H, PHE89G, PHE89H, PRO114G, PRO114H, PRO144G, PRO144H, PRO86G, PRO86H, PRO96G, PRO96H, SER10G, SER10H, SER112G, SER112H, SER116G, SER116H, SER165G, SER165H, SER78G, SER78H, THR171G, THR171H, THR175G, THR175H, THR48G, THR48H, THR74G, THR74H, THR97G, THR97H, TYR143G, TYR143H, TYR49G, TYR49H, VAL172G, VAL172H, VAL176G, VAL176H, VAL50G, VAL50H, VAL88G, VAL88H, VAL93G, VAL93H
• G-J: ALA186G, ALA191G, ALA191J, ALA202G, ALA204G, ALA204J, ARG208G, ARG208J, ASN197G, ASN197J, ASN205G, ASN205J, ASP201G, ASP201J, ASP211J, CYS198G, CYS198J, GLU188G, GLU188J, GLU192G, GLU192J, GLY187G, GLY187J, LEU193G, LEU193J, LEU207G, LEU207J, LEU210G, LEU210J, LYS189G, LYS189J, PHE190G, PHE190J, PHE194G, PHE194J, PRO196G, PRO196J, SER209G, SER209J, TYR195G, TYR195J, TYR206G, TYR206J
• G-P: ALA16G, ARG139P, ARG152P, GLN128G, GLU138P, GLU149P, GLU20G, GLU42G, LEU125G, LEU141P, LYS153P, THR40G, VAL17G
• I-J: ALA110I, ALA110J, ALA12I, ALA12J, ALA164I, ALA164J, ALA184I, ALA184J, ALA81I, ALA81J, ALA82I, ALA82J, ALA84I, ALA84J, ALA99I, ALA99J, ARG147I, ARG147J, ARG152I, ARG152J, ARG155I, ARG155J, ARG159I, ARG159J, ARG167I, ARG167J, ASN106I, ASN106J, ASN109I, ASN109J, ASN154I, ASN154J, ASN52I, ASN52J, ASN83I, ASN83J, ASN9I, ASN9J, ASP107I, ASP107J, ASP163I, ASP163J, ASP168I, ASP168J, ASP177I, ASP177J, ASP95I, ASP95J, ASP98I, ASP98J, CYS166I, CYS166J, CYS90I, CYS90J, GLN11I, GLN11J, GLU160I, GLU160J, GLU8I, GLU8J, GLY108I, GLY108J, GLY118I, GLY118J, GLY156I, GLY156J, GLY53I, GLY53J, GLY57I, GLY57J, GLY73I, GLY73J, GLY75I, GLY75J, GLY77I, GLY77J, GLY91I, GLY91J, ILE105I, ILE105J, ILE111I, ILE111J, ILE150I, ILE150J, ILE157I, ILE157J, ILE94I, ILE94J, LEU101I, LEU101J, LEU158I, LEU158J, LEU161I, LEU161J, LEU173I, LEU173J, LEU180I, LEU180J, LEU181I, LEU181J, LEU47I, LEU47J, LEU54I, LEU54J, LEU55I, LEU55J, LEU80I, LEU80J, LEU92I, LEU92J, LYS117I, LYS117J, LYS153I, LYS153J, LYS162I, LYS162J, LYS174I, LYS174J, PHE100I, PHE100J, PHE102I, PHE102J, PHE89I, PHE89J, PRO114I, PRO114J, PRO144I, PRO144J, PRO86I, PRO86J, PRO96I, PRO96J, SER10I, SER10J, SER112I, SER112J, SER116I, SER116J, SER165I, SER165J, SER46J, SER78I, SER78J, THR171I, THR171J, THR175I, THR175J, THR48I, THR48J, THR74I, THR74J, THR97I, THR97J, TYR143I, TYR143J, TYR49I, TYR49J, VAL172I, VAL172J, VAL176I, VAL176J, VAL50I, VAL50J, VAL88I, VAL88J, VAL93I, VAL93J
• I-K: ALA122I, ALA122K, ALA123I, ALA123K, ASN126I, ASN126K, ASP95I, GLN11I, GLN11K, GLU8I, GLU8K, GLY118I, GLY118K, GLY120I, GLY120K, GLY73I, GLY73K, GLY75I, GLY75K, LEU125I, LEU125K, LYS117I, LYS117K, LYS14I, LYS14K, PHE119I, PHE119K, PRO114I, PRO114K, SER10I, SER10K, SER116I, SER116K, THR74I, THR74K, TRP121I, TRP121K, TYR115I, TYR115K
• I-L: ALA122I, ALA122L, ALA123I, ALA123L, ARG132I, ARG132L, ARG145I, ARG145L, ARG147I, ARG147L, ASN106I, ASN126I, ASN126L, ASP129I, ASP129L, ASP95I, ASP95L, ASP98I, ASP98L, GLN104I, GLN104L, GLN128I, GLN128L, GLU124I, GLU124L, GLU146I, GLY120I, GLY120L, GLY142I, ILE105I, ILE105L, ILE94I, ILE94L, LEU101I, LEU101L, LEU125I, LEU125L, LEU127I, LEU127L, LYS133I, LYS133L, PHE100I, PHE100L, PRO144I, PRO144L, PRO96I, PRO96L, THR97I, THR97L, TRP121I, TRP121L, TYR143I, TYR143L, VAL130I, VAL130L
• I-O: ALA164I, ARG167I, ASP163I, ASP168I, ASP168O, GLU160I, LEU170O, LYS174O, THR171I, THR171O
• I-P: ARG167I, ARG167P, THR171I, THR171P, THR175P
• J-K: ALA122J, ALA122K, ALA123J, ALA123K, ARG132J, ARG132K, ARG145J, ARG147J, ARG147K, ASN126J, ASN126K, ASP129J, ASP129K, ASP95J, ASP95K, ASP98J, ASP98K, GLN104J, GLN104K, GLN128J, GLN128K, GLU124J, GLU124K, GLY120J, GLY120K, ILE105J, ILE105K, ILE94J, ILE94K, LEU101J, LEU101K, LEU125J, LEU125K, LEU127J, LEU127K, LYS133J, LYS133K, PHE100J, PHE100K, PRO144J, PRO144K, PRO96J, PRO96K, THR97J, THR97K, TRP121J, TRP121K, TYR143J, TYR143K, VAL130J, VAL130K
• J-L: ALA122J, ALA122L, ALA123J, ALA123L, ASN126J, ASN126L, ASP95L, GLN11J, GLN11L, GLU8J, GLU8L, GLY118J, GLY118L, GLY120J, GLY120L, GLY73J, GLY73L, GLY75J, GLY75L, LEU125J, LYS117J, LYS117L, LYS14J, LYS14L, PHE119J, PHE119L, PRO114J, PRO114L, SER10J, SER10L, SER116J, SER116L, THR74J, THR74L, TRP121J, TRP121L, TYR115J, TYR115L, TYR49J
• J-O: ARG167J, ARG167O, ASP168J, ASP168O, GLN178J, GLN178O, LEU170J, LEU170O, LEU173J, LEU173O, LYS174J, LYS174O, THR171J, THR171O, THR175J, THR175O, TYR206J, TYR206O, VAL172J, VAL172O, VAL176J, VAL176O
• J-P: ALA164P, ARG167J, ARG167P, ASP163P, ASP168J, ASP168P, LEU170J, LYS174J, THR171J, THR171P
• K-L: ALA110K, ALA110L, ALA12K, ALA12L, ALA164K, ALA164L, ALA184K, ALA81K, ALA81L, ALA82K, ALA82L, ALA84K, ALA84L, ALA99K, ALA99L, ARG147K, ARG147L, ARG152K, ARG152L, ARG155K, ARG155L, ARG159K, ARG159L, ARG167K, ARG167L, ASN106K, ASN106L, ASN109K, ASN109L, ASN154K, ASN154L, ASN52K, ASN52L, ASN83K, ASN83L, ASN9K, ASN9L, ASP107K, ASP107L, ASP163K, ASP163L, ASP168K, ASP168L, ASP177K, ASP177L, ASP95K, ASP95L, ASP98K, ASP98L, CYS166K, CYS166L, CYS90K, CYS90L, GLN11K, GLN11L, GLU160K, GLU160L, GLU8K, GLU8L, GLY108K, GLY108L, GLY118K, GLY118L, GLY156K, GLY156L, GLY53K, GLY53L, GLY57K, GLY57L, GLY73K, GLY73L, GLY75K, GLY75L, GLY77K, GLY77L, GLY91K, GLY91L, ILE105K, ILE105L, ILE111K, ILE111L, ILE150K, ILE150L, ILE157K, ILE157L, ILE94K, ILE94L, LEU101K, LEU101L, LEU158K, LEU158L, LEU161K, LEU161L, LEU173K, LEU173L, LEU180K, LEU180L, LEU181K, LEU181L, LEU47K, LEU47L, LEU54K, LEU54L, LEU55K, LEU55L, LEU80K, LEU80L, LEU92K, LEU92L, LYS117K, LYS117L, LYS153K, LYS153L, LYS162K, LYS162L, LYS174K, LYS174L, PHE100K, PHE100L, PHE102K, PHE102L, PHE89K, PHE89L, PRO114K, PRO114L, PRO144K, PRO144L, PRO86K, PRO86L, PRO96K, PRO96L, SER10K, SER10L, SER112K, SER112L, SER116K, SER116L, SER165K, SER165L, SER46L, SER78K, SER78L, THR171K, THR171L, THR175K, THR175L, THR48K, THR48L, THR74K, THR74L, THR97K, THR97L, TYR143K, TYR143L, TYR49K, TYR49L, VAL172K, VAL172L, VAL176K, VAL176L, VAL50K, VAL50L, VAL88K, VAL88L, VAL93K, VAL93L
• M-N: ALA110M, ALA110N, ALA12M, ALA12N, ALA164M, ALA164N, ALA184M, ALA184N, ALA81M, ALA81N, ALA82M, ALA82N, ALA84M, ALA84N, ALA99M, ALA99N, ARG147M, ARG147N, ARG152M, ARG152N, ARG155M, ARG155N, ARG159M, ARG159N, ARG167M, ARG167N, ASN106M, ASN106N, ASN109M, ASN109N, ASN154M, ASN154N, ASN52M, ASN52N, ASN83M, ASN83N, ASN9M, ASN9N, ASP107M, ASP107N, ASP163M, ASP163N, ASP168M, ASP168N, ASP177M, ASP177N, ASP95M, ASP95N, ASP98M, ASP98N, CYS166M, CYS166N, CYS90M, CYS90N, GLN11M, GLN11N, GLU160M, GLU160N, GLU8M, GLU8N, GLY108M, GLY108N, GLY118M, GLY118N, GLY156M, GLY156N, GLY53M, GLY53N, GLY57M, GLY57N, GLY73M, GLY73N, GLY75M, GLY75N, GLY77M, GLY77N, GLY87M, GLY91M, GLY91N, ILE105M, ILE105N, ILE111M, ILE111N, ILE150M, ILE150N, ILE157M, ILE157N, ILE58M, ILE94M, ILE94N, LEU101M, LEU101N, LEU158M, LEU158N, LEU161M, LEU161N, LEU173M, LEU173N, LEU180M, LEU180N, LEU181M, LEU181N, LEU47M, LEU47N, LEU54M, LEU54N, LEU55M, LEU55N, LEU80M, LEU80N, LEU92M, LEU92N, LYS117M, LYS117N, LYS153M, LYS153N, LYS162M, LYS162N, LYS174M, LYS174N, PHE100M, PHE100N, PHE102M, PHE102N, PHE89M, PHE89N, PRO114M, PRO114N, PRO144M, PRO86M, PRO86N, PRO96M, PRO96N, SER10M, SER10N, SER112M, SER116M, SER116N, SER165M, SER165N, SER46M, SER78M, SER78N, THR171M, THR171N, THR175M, THR175N, THR48M, THR48N, THR74M, THR74N, THR97M, THR97N, TYR143M, TYR143N, TYR49M, TYR49N, VAL172M, VAL172N, VAL176M, VAL176N, VAL50M, VAL50N, VAL88M, VAL88N, VAL93M, VAL93N
• M-O: ALA122M, ALA122O, ALA123M, ALA123O, ASN126M, ASN126O, ASP95M, GLN11M, GLN11O, GLU8O, GLY118M, GLY118O, GLY120M, GLY120O, GLY73M, GLY73O, GLY75O, LEU125O, LYS117M, LYS117O, LYS14M, LYS14O, PHE119M, PHE119O, PRO114M, PRO114O, SER10O, SER116M, SER116O, THR74M, THR74O, TRP121M, TRP121O, TYR115M, TYR115O, TYR49O
• M-P: ALA122M, ALA122P, ALA123M, ALA123P, ARG132M, ARG132P, ARG147M, ARG147P, ASN126M, ASN126P, ASP129M, ASP129P, ASP95M, ASP95P, ASP98M, ASP98P, GLN104M, GLN104P, GLN128M, GLN128P, GLU124M, GLU124P, GLU146M, GLU146P, GLY120M, GLY120P, ILE105M, ILE105P, ILE94M, ILE94P, LEU101M, LEU101P, LEU125M, LEU125P, LEU127M, LEU127P, LYS133M, LYS133P, PHE100M, PHE100P, PRO144M, PRO144P, PRO96M, PRO96P, THR97M, THR97P, TRP121M, TRP121P, TYR143M, TYR143P, VAL130M, VAL130P
• N-O: ALA122N, ALA122O, ALA123N, ALA123O, ARG132N, ARG132O, ARG145N, ARG147N, ARG147O, ASN126N, ASN126O, ASP129N, ASP129O, ASP95N, ASP95O, ASP98N, ASP98O, GLN104N, GLN104O, GLN128N, GLN128O, GLU124N, GLU124O, GLU146N, GLY120N, GLY120O, ILE105N, ILE105O, ILE94N, ILE94O, LEU101N, LEU101O, LEU125N, LEU125O, LEU127N, LEU127O, LYS133N, LYS133O, PHE100N, PHE100O, PRO144N, PRO144O, PRO96N, PRO96O, THR97N, THR97O, TRP121N, TRP121O, TYR143N, TYR143O, VAL130N, VAL130O
• N-P: ALA122N, ALA122P, ALA123N, ALA123P, ASN126N, ASN126P, GLN11N, GLN11P, GLU8N, GLU8P, GLY118N, GLY118P, GLY120N, GLY120P, GLY73N, GLY73P, GLY75N, GLY75P, LEU125N, LEU125P, LYS117N, LYS117P, LYS14N, LYS14P, PHE119N, PHE119P, PRO114N, PRO114P, SER10N, SER10P, SER116N, SER116P, THR74N, THR74P, TRP121N, TRP121P, TYR115N, TYR115P
• O-P: ALA110O, ALA110P, ALA12O, ALA164O, ALA164P, ALA184O, ALA56O, ALA81O, ALA81P, ALA82O, ALA82P, ALA84O, ALA84P, ALA99O, ALA99P, ARG147O, ARG147P, ARG152O, ARG152P, ARG155O, ARG155P, ARG159O, ARG159P, ARG167O, ARG167P, ASN106O, ASN106P, ASN109O, ASN109P, ASN154O, ASN154P, ASN52O, ASN52P, ASN83O, ASN83P, ASN9O, ASN9P, ASP107O, ASP107P, ASP163O, ASP163P, ASP168O, ASP168P, ASP177O, ASP177P, ASP95O, ASP95P, ASP98O, ASP98P, CYS166O, CYS166P, CYS90O, CYS90P, GLN11O, GLU160O, GLU160P, GLU8O, GLU8P, GLY108O, GLY108P, GLY118O, GLY118P, GLY156O, GLY156P, GLY53O, GLY53P, GLY57O, GLY57P, GLY73O, GLY73P, GLY75O, GLY75P, GLY77O, GLY77P, GLY91O, GLY91P, ILE105O, ILE105P, ILE111O, ILE111P, ILE150O, ILE150P, ILE157O, ILE157P, ILE94O, ILE94P, LEU101O, LEU101P, LEU158O, LEU158P, LEU161O, LEU161P, LEU173O, LEU173P, LEU180O, LEU180P, LEU181O, LEU181P, LEU47O, LEU47P, LEU54O, LEU54P, LEU55O, LEU55P, LEU80O, LEU80P, LEU92O, LEU92P, LYS117O, LYS117P, LYS153O, LYS153P, LYS162O, LYS162P, LYS174O, LYS174P, PHE100O, PHE100P, PHE102O, PHE102P, PHE89O, PHE89P, PRO114O, PRO114P, PRO144P, PRO86O, PRO86P, PRO96O, PRO96P, SER10O, SER10P, SER112O, SER112P, SER116O, SER116P, SER165O, SER165P, SER78O, SER78P, THR171O, THR171P, THR175O, THR175P, THR48O, THR48P, THR74O, THR74P, THR97O, THR97P, TYR143O, TYR143P, TYR49O, TYR49P, VAL172O, VAL172P, VAL176O, VAL176P, VAL50O, VAL50P, VAL88O, VAL88P, VAL93O, VAL93P