3BV6

crystal structure of uncharacterized metallo protein from vibrio cholerae with beta-lactamase like fold

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 332
  • Norm. En. per Res.: -5.9879
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-128.0027	-221.7175	-404.004	-753.7242	149	14	1	14256	18	52	63
A-C	-68.808	-25.1316	-204.67	-298.6096	69	8	4	7318	6	23	32
A-D	0.0	0.0	-17.1056	-17.1056	11	2	0	533	0	0	0
A-E	-72.6451	-28.0005	-203.453	-304.0987	70	8	4	7319	6	23	32
A-F	-317.5336	-122.1655	-1548.3	-1987.9991	332	59	29	54532	9	93	59
B-C	-301.2747	-117.4284	-1561.86	-1980.563	333	64	29	54450	10	92	62
B-D	-79.5596	-33.7456	-208.894	-322.1992	69	12	4	7466	5	23	32
B-E	0.0	0.0	-15.666	-15.666	10	2	0	498	0	0	0
B-F	-78.0188	-35.688	-205.837	-319.5438	72	8	4	7368	6	23	32
C-D	-104.3123	-215.1803	-380.154	-699.6466	147	13	1	13822	18	52	63
C-E	-72.5102	-36.4076	-204.349	-313.2668	71	8	4	7429	6	23	32
C-F	0.0	0.0	-15.9939	-15.9939	11	1	0	503	0	0	0
D-E	-310.7439	-127.594	-1551.96	-1990.2979	338	57	29	54620	10	94	62
D-F	-77.7716	-27.2463	-201.734	-306.7519	71	11	4	7311	6	23	32
E-F	-123.0927	-223.5794	-400.247	-746.9192	148	20	1	14296	18	53	62

Interface residues

• A-B: ALA201A, ALA201B, ALA235A, ALA235B, ALA269A, ALA269B, ALA270A, ALA270B, ARG185A, ARG185B, ARG255A, ARG255B, ARG268A, ARG268B, ARG294A, ARG294B, ARG306A, ARG306B, ASN232A, ASN232B, ASN239A, ASN239B, ASN253A, ASN253B, ASN288B, ASN291A, ASN291B, ASN301A, ASN301B, ASP199A, ASP199B, ASP204A, ASP204B, ASP240A, ASP240B, ASP259A, ASP259B, ASP265A, ASP265B, ASP274A, ASP274B, ASP292A, ASP292B, CYS275A, CYS275B, GLN290A, GLN290B, GLU252A, GLU252B, GLU271A, GLU271B, GLU295A, GLU295B, GLU297A, GLU297B, GLY205A, GLY205B, GLY238A, GLY238B, GLY251A, GLY251B, GLY256A, GLY256B, GLY86A, GLY86B, GLY87A, HIS229A, HIS229B, HIS237A, HIS237B, ILE202A, ILE202B, ILE243A, ILE243B, ILE296A, ILE296B, LEU188A, LEU188B, LEU203A, LEU203B, LEU267A, LEU267B, LEU273A, LEU273B, LEU299A, LEU299B, LEU307A, LEU307B, LYS200A, LYS200B, LYS236A, LYS236B, LYS260A, LYS260B, LYS303A, LYS303B, MET261A, MET261B, MET302A, MET302B, MET82A, MET82B, MET85A, MET85B, PHE289A, PHE289B, PHE311A, PHE311B, PRO254A, PRO254B, PRO293A, PRO293B, SER231A, SER231B, SER263A, SER263B, SER264A, SER264B, SER272A, SER272B, THR186B, THR258A, THR258B, THR262A, THR262B, TRP300A, TRP300B, TYR198A, TYR198B, TYR230A, TYR230B, TYR233A, TYR233B, TYR234A, TYR234B, TYR241A, TYR241B, TYR250A, TYR250B, TYR309A, TYR309B, VAL257A, VAL257B, VAL266A, VAL266B, VAL298A, VAL298B, VAL88A, VAL88B
• A-C: ALA235A, ALA353C, ARG185A, ARG268A, ARG294C, ARG306A, ARG330C, ARG337C, ASN232A, ASN239A, ASN301A, ASN345C, ASP181A, ASP184A, ASP204A, ASP207A, ASP240A, ASP305A, ASP341C, GLN308A, GLN310A, GLN317C, GLN334C, GLN340C, GLU271A, GLU297C, GLU346C, GLY205A, GLY238A, GLY329C, HIS229A, HIS237A, HIS332C, HIS335C, ILE202A, ILE342C, LEU188A, LEU203A, LEU307A, LEU349C, LEU355C, LYS200A, LYS236A, LYS303A, LYS304A, LYS344C, LYS352C, MET206A, MET302A, MET331C, PHE183A, PHE314C, PHE315C, PHE339C, PHE343C, PHE354C, PRO347C, PRO350C, SER182A, SER228A, SER231A, SER272A, TYR230A, TYR233A, TYR234A, TYR309A, TYR333C, TYR351C, VAL166A
• A-D: ALA353A, ALA353D, LEU349D, LEU355A, LEU355D, PHE354A, PHE354D, PRO350A, PRO350D, TYR351A, TYR351D
• A-E: ALA235E, ALA353A, ARG185E, ARG268E, ARG294A, ARG306E, ARG330A, ARG337A, ASN232E, ASN239E, ASN301E, ASN345A, ASP181E, ASP184E, ASP204E, ASP207E, ASP240E, ASP305E, ASP341A, GLN308E, GLN317A, GLN334A, GLN340A, GLU271E, GLU297A, GLU346A, GLY205E, GLY238E, GLY329A, HIS229E, HIS237E, HIS332A, HIS335A, ILE202E, ILE342A, LEU180E, LEU188E, LEU203E, LEU307E, LEU349A, LEU355A, LYS200E, LYS236E, LYS303E, LYS304E, LYS344A, LYS352A, MET206E, MET302E, MET331A, PHE183E, PHE314A, PHE315A, PHE339A, PHE343A, PHE354A, PRO347A, PRO350A, SER182E, SER228E, SER231E, SER272E, TYR230E, TYR233E, TYR234E, TYR309E, TYR333A, TYR351A, VAL166E, VAL189E
• A-F: ALA106A, ALA106F, ALA128A, ALA128F, ALA129A, ALA129F, ALA130A, ALA130F, ALA187A, ALA187F, ALA201A, ALA201F, ALA287A, ALA287F, ALA353A, ALA353F, ALA90A, ALA90F, ARG185A, ARG185F, ARG255A, ARG255F, ARG294A, ARG294F, ARG330F, ARG337A, ARG337F, ARG74A, ARG74F, ARG84A, ARG84F, ARG96A, ARG96F, ARG9A, ARG9F, ASN126A, ASN126F, ASN134A, ASN134F, ASN253A, ASN253F, ASN25A, ASN25F, ASN288A, ASN288F, ASN291A, ASN291F, ASN345A, ASN345F, ASN5A, ASN5F, ASN73A, ASN73F, ASN94A, ASN94F, ASP103A, ASP103F, ASP124A, ASP124F, ASP184A, ASP184F, ASP199A, ASP199F, ASP259A, ASP259F, ASP284A, ASP284F, ASP292A, ASP292F, ASP341A, ASP341F, CYS64A, CYS64F, GLN133A, GLN133F, GLN290A, GLN290F, GLN30A, GLN30F, GLN317A, GLN317F, GLN334A, GLN334F, GLN340A, GLN340F, GLN71A, GLN71F, GLN79A, GLN79F, GLN81A, GLN81F, GLN92A, GLN92F, GLU10A, GLU10F, GLU19A, GLU19F, GLU252A, GLU252F, GLU26A, GLU26F, GLU27A, GLU27F, GLU297A, GLU297F, GLU29A, GLU346A, GLU346F, GLU348A, GLU348F, GLU6A, GLU6F, GLU89A, GLU89F, GLY153A, GLY153F, GLY155A, GLY155F, GLY194A, GLY194F, GLY21A, GLY21F, GLY256A, GLY256F, GLY319A, GLY319F, GLY320A, GLY320F, GLY338A, GLY338F, GLY65A, GLY65F, GLY67A, GLY67F, GLY86A, GLY86F, GLY87A, GLY87F, HIS229A, HIS229F, HIS332A, HIS332F, HIS335A, HIS335F, HIS80A, HIS80F, ILE107F, ILE13A, ILE13F, ILE202A, ILE202F, ILE285A, ILE285F, ILE28A, ILE28F, ILE342A, ILE342F, ILE7A, ILE7F, ILE99A, ILE99F, LEU102A, LEU102F, LEU132A, LEU132F, LEU14A, LEU14F, LEU150A, LEU150F, LEU152A, LEU152F, LEU188A, LEU188F, LEU191A, LEU191F, LEU203A, LEU203F, LEU24A, LEU24F, LEU349A, LEU349F, LEU355A, LEU355F, LEU75A, LEU75F, LEU91A, LEU91F, LEU95A, LEU95F, LYS108A, LYS193A, LYS200A, LYS200F, LYS260A, LYS344A, LYS344F, LYS352A, LYS352F, LYS3A, LYS3F, LYS68A, LYS68F, LYS69A, LYS69F, LYS72A, LYS72F, MET206A, MET206F, MET76A, MET76F, MET82A, MET82F, MET83A, MET83F, MET85A, MET85F, PHE100A, PHE100F, PHE105A, PHE105F, PHE141A, PHE141F, PHE17A, PHE17F, PHE183A, PHE183F, PHE289A, PHE289F, PHE315A, PHE315F, PHE336A, PHE336F, PHE339A, PHE339F, PHE343A, PHE343F, PHE354A, PHE354F, PHE62A, PHE62F, PRO101A, PRO101F, PRO104A, PRO104F, PRO157A, PRO157F, PRO18A, PRO18F, PRO254A, PRO254F, PRO347A, PRO347F, PRO350A, PRO350F, PRO93A, PRO93F, SER11A, SER11F, SER15A, SER15F, SER196A, SER196F, SER197A, SER197F, SER2F, SER98A, SER98F, THR16A, THR16F, THR186A, THR186F, THR190A, THR190F, THR22A, THR22F, THR258A, THR258F, THR66A, THR66F, THR70A, THR70F, THR78F, THR8A, THR8F, THR97A, THR97F, TRP12A, TRP12F, TRP151A, TRP151F, TRP154A, TRP154F, TRP20A, TRP20F, TRP23A, TRP23F, TRP286A, TRP286F, TRP316A, TRP316F, TRP63A, TRP63F, TYR198A, TYR198F, TYR230A, TYR230F, TYR333A, TYR333F, TYR351A, TYR351F, VAL125A, VAL125F, VAL127A, VAL127F, VAL131A, VAL131F, VAL156A, VAL156F, VAL189A, VAL189F, VAL195A, VAL195F, VAL257A, VAL257F, VAL298A, VAL298F, VAL318A, VAL318F, VAL4A, VAL4F, VAL88A, VAL88F
• B-C: ALA106B, ALA106C, ALA128B, ALA128C, ALA129B, ALA129C, ALA130B, ALA130C, ALA187B, ALA187C, ALA201B, ALA201C, ALA287B, ALA287C, ALA353B, ALA353C, ALA90B, ALA90C, ARG185B, ARG185C, ARG255B, ARG255C, ARG294B, ARG294C, ARG330B, ARG337B, ARG337C, ARG74B, ARG74C, ARG84B, ARG84C, ARG96B, ARG96C, ARG9B, ARG9C, ASN126B, ASN126C, ASN134B, ASN134C, ASN253B, ASN253C, ASN25B, ASN25C, ASN288B, ASN288C, ASN291B, ASN291C, ASN345B, ASN345C, ASN5B, ASN5C, ASN73B, ASN73C, ASN94B, ASN94C, ASP103B, ASP103C, ASP124B, ASP124C, ASP184B, ASP184C, ASP199B, ASP199C, ASP259B, ASP259C, ASP284B, ASP284C, ASP292B, ASP292C, ASP341B, ASP341C, CYS64B, CYS64C, GLN133B, GLN133C, GLN290B, GLN290C, GLN30B, GLN30C, GLN317B, GLN317C, GLN334B, GLN334C, GLN340B, GLN340C, GLN71B, GLN71C, GLN79B, GLN79C, GLN81B, GLN81C, GLN92B, GLN92C, GLU10B, GLU10C, GLU19B, GLU19C, GLU252B, GLU252C, GLU26B, GLU26C, GLU27B, GLU27C, GLU297B, GLU297C, GLU346B, GLU346C, GLU348B, GLU348C, GLU6B, GLU6C, GLU89B, GLU89C, GLY153B, GLY153C, GLY155B, GLY155C, GLY194B, GLY194C, GLY21B, GLY21C, GLY256B, GLY256C, GLY319B, GLY319C, GLY320B, GLY320C, GLY338B, GLY338C, GLY65B, GLY65C, GLY67B, GLY67C, GLY86B, GLY86C, GLY87B, GLY87C, HIS229B, HIS229C, HIS332B, HIS332C, HIS335B, HIS335C, HIS80B, HIS80C, ILE107B, ILE107C, ILE13B, ILE13C, ILE202B, ILE202C, ILE285B, ILE285C, ILE28B, ILE28C, ILE342B, ILE342C, ILE7B, ILE7C, ILE99B, ILE99C, LEU102B, LEU102C, LEU132B, LEU132C, LEU14B, LEU14C, LEU150C, LEU152B, LEU152C, LEU188B, LEU188C, LEU191B, LEU191C, LEU203B, LEU203C, LEU24B, LEU24C, LEU349B, LEU349C, LEU355B, LEU355C, LEU75B, LEU75C, LEU91B, LEU91C, LEU95B, LEU95C, LYS108B, LYS193B, LYS193C, LYS200B, LYS200C, LYS260B, LYS260C, LYS344B, LYS344C, LYS352B, LYS352C, LYS3B, LYS3C, LYS68B, LYS68C, LYS69B, LYS69C, LYS72B, LYS72C, MET206B, MET206C, MET76B, MET76C, MET82B, MET82C, MET83B, MET83C, MET85B, MET85C, PHE100B, PHE100C, PHE105B, PHE105C, PHE141B, PHE141C, PHE17B, PHE17C, PHE183B, PHE183C, PHE289B, PHE289C, PHE315B, PHE315C, PHE336B, PHE336C, PHE339B, PHE339C, PHE343B, PHE343C, PHE354B, PHE354C, PHE62B, PHE62C, PRO101B, PRO101C, PRO104B, PRO104C, PRO157B, PRO157C, PRO18B, PRO18C, PRO254B, PRO254C, PRO347B, PRO347C, PRO350B, PRO350C, PRO93B, PRO93C, SER11B, SER11C, SER15B, SER15C, SER196B, SER196C, SER197B, SER197C, SER2B, SER98B, SER98C, THR16B, THR16C, THR186B, THR186C, THR190B, THR190C, THR22B, THR22C, THR258B, THR258C, THR66B, THR66C, THR70B, THR70C, THR78B, THR8B, THR8C, THR97B, THR97C, TRP12B, TRP12C, TRP151B, TRP151C, TRP154B, TRP154C, TRP20B, TRP20C, TRP23B, TRP23C, TRP286B, TRP286C, TRP316B, TRP316C, TRP63B, TRP63C, TYR198B, TYR198C, TYR230B, TYR230C, TYR333B, TYR333C, TYR351B, TYR351C, VAL125B, VAL125C, VAL127B, VAL127C, VAL131B, VAL131C, VAL156B, VAL156C, VAL189B, VAL189C, VAL195B, VAL195C, VAL257B, VAL257C, VAL298B, VAL298C, VAL318B, VAL318C, VAL4B, VAL4C, VAL88B, VAL88C
• B-D: ALA235D, ALA353B, ARG185D, ARG268D, ARG294B, ARG306D, ARG330B, ARG337B, ASN232D, ASN239D, ASN301D, ASN345B, ASP181D, ASP184D, ASP204D, ASP207D, ASP240D, ASP305D, ASP341B, GLN308D, GLN310D, GLN317B, GLN334B, GLN340B, GLU271D, GLU297B, GLU346B, GLY205D, GLY238D, GLY329B, HIS229D, HIS237D, HIS332B, HIS335B, ILE202D, ILE342B, LEU188D, LEU203D, LEU307D, LEU349B, LEU355B, LYS200D, LYS236D, LYS303D, LYS304D, LYS344B, LYS352B, MET206D, MET302D, MET331B, PHE183D, PHE314B, PHE315B, PHE339B, PHE343B, PHE354B, PRO347B, PRO350B, SER182D, SER228D, SER231D, SER272D, TYR230D, TYR233D, TYR234D, TYR309D, TYR333B, TYR351B, VAL166D
• B-E: ALA353B, ALA353E, LEU355B, LEU355E, PHE354B, PHE354E, PRO350B, PRO350E, TYR351B, TYR351E
• B-F: ALA235B, ALA353F, ARG185B, ARG268B, ARG294F, ARG306B, ARG330F, ARG337F, ASN232B, ASN239B, ASN301B, ASN345F, ASP181B, ASP184B, ASP204B, ASP207B, ASP240B, ASP305B, ASP341F, GLN308B, GLN310B, GLN317F, GLN334F, GLN340F, GLU271B, GLU297F, GLU346F, GLY205B, GLY238B, GLY329F, HIS229B, HIS237B, HIS332F, HIS335F, ILE202B, ILE342F, LEU180B, LEU188B, LEU203B, LEU307B, LEU349F, LEU355F, LYS200B, LYS236B, LYS303B, LYS304B, LYS344F, LYS352F, MET206B, MET302B, MET331F, PHE183B, PHE311B, PHE314F, PHE315F, PHE339F, PHE343F, PHE354F, PRO347F, PRO350F, SER182B, SER228B, SER231B, SER272B, TYR230B, TYR233B, TYR234B, TYR309B, TYR333F, TYR351F, VAL166B, VAL189B
• C-D: ALA201C, ALA201D, ALA235C, ALA235D, ALA269C, ALA269D, ALA270C, ALA270D, ARG185C, ARG185D, ARG255C, ARG255D, ARG268C, ARG268D, ARG294C, ARG294D, ARG306C, ARG306D, ASN232C, ASN232D, ASN239C, ASN239D, ASN253C, ASN253D, ASN288C, ASN291C, ASN291D, ASP199C, ASP199D, ASP204C, ASP204D, ASP240C, ASP240D, ASP259C, ASP259D, ASP265C, ASP265D, ASP274C, ASP274D, ASP292C, ASP292D, CYS275C, CYS275D, GLN290C, GLN290D, GLU252C, GLU252D, GLU271C, GLU271D, GLU295C, GLU295D, GLU297C, GLU297D, GLY205C, GLY205D, GLY238C, GLY238D, GLY251C, GLY251D, GLY256C, GLY256D, GLY86C, GLY86D, GLY87C, HIS229C, HIS229D, HIS237C, HIS237D, ILE202C, ILE202D, ILE243C, ILE243D, ILE296C, ILE296D, LEU188C, LEU188D, LEU203C, LEU203D, LEU267C, LEU267D, LEU273C, LEU273D, LEU299C, LEU299D, LEU307C, LEU307D, LYS200C, LYS200D, LYS236C, LYS236D, LYS260C, LYS260D, LYS303C, LYS303D, MET261C, MET261D, MET302C, MET302D, MET82C, MET82D, MET85C, MET85D, PHE289C, PHE289D, PHE311C, PHE311D, PRO254C, PRO254D, PRO293C, PRO293D, SER231C, SER231D, SER263C, SER263D, SER264C, SER264D, SER272C, SER272D, THR186C, THR258C, THR258D, THR262C, THR262D, TRP300C, TRP300D, TYR198C, TYR198D, TYR230C, TYR230D, TYR233C, TYR233D, TYR234C, TYR234D, TYR241C, TYR241D, TYR250C, TYR250D, TYR309C, TYR309D, VAL257C, VAL257D, VAL266C, VAL266D, VAL298C, VAL298D, VAL88C, VAL88D
• C-E: ALA235C, ALA353E, ARG185C, ARG268C, ARG294E, ARG306C, ARG330E, ARG337E, ASN232C, ASN239C, ASN301C, ASN345E, ASP181C, ASP184C, ASP204C, ASP207C, ASP240C, ASP305C, ASP341E, GLN308C, GLN310C, GLN317E, GLN334E, GLN340E, GLU271C, GLU297E, GLU346E, GLY205C, GLY238C, GLY329E, HIS229C, HIS237C, HIS332E, HIS335E, ILE202C, ILE342E, LEU180C, LEU188C, LEU203C, LEU307C, LEU349E, LEU355E, LYS200C, LYS236C, LYS303C, LYS304C, LYS344E, LYS352E, MET206C, MET302C, MET331E, PHE183C, PHE311C, PHE314E, PHE315E, PHE339E, PHE343E, PHE354E, PRO347E, PRO350E, SER182C, SER228C, SER231C, SER272C, TYR230C, TYR233C, TYR234C, TYR309C, TYR333E, TYR351E, VAL166C
• C-F: ALA353C, ALA353F, LEU349C, LEU355C, LEU355F, PHE354C, PHE354F, PRO350C, PRO350F, TYR351C, TYR351F
• D-E: ALA106D, ALA106E, ALA128D, ALA128E, ALA129D, ALA129E, ALA130D, ALA130E, ALA187D, ALA187E, ALA201D, ALA201E, ALA287D, ALA287E, ALA353D, ALA353E, ALA90D, ALA90E, ARG185D, ARG185E, ARG255D, ARG255E, ARG294D, ARG294E, ARG330E, ARG337D, ARG337E, ARG74D, ARG74E, ARG84D, ARG84E, ARG96D, ARG96E, ARG9D, ARG9E, ASN126D, ASN126E, ASN134D, ASN134E, ASN253D, ASN253E, ASN25D, ASN25E, ASN288D, ASN288E, ASN291D, ASN291E, ASN345D, ASN345E, ASN5D, ASN5E, ASN73D, ASN73E, ASN94D, ASN94E, ASP103D, ASP103E, ASP124D, ASP124E, ASP184D, ASP184E, ASP199D, ASP199E, ASP259D, ASP259E, ASP284D, ASP284E, ASP292D, ASP292E, ASP341D, ASP341E, CYS64D, CYS64E, GLN133D, GLN133E, GLN290D, GLN290E, GLN30D, GLN30E, GLN317D, GLN317E, GLN334D, GLN334E, GLN340D, GLN340E, GLN71D, GLN71E, GLN79D, GLN79E, GLN81D, GLN81E, GLN92D, GLN92E, GLU10D, GLU10E, GLU19D, GLU19E, GLU252D, GLU252E, GLU26D, GLU26E, GLU27D, GLU27E, GLU297D, GLU297E, GLU29D, GLU29E, GLU346D, GLU346E, GLU348D, GLU348E, GLU6D, GLU6E, GLU89D, GLU89E, GLY153D, GLY153E, GLY155D, GLY155E, GLY194D, GLY194E, GLY21D, GLY21E, GLY256D, GLY256E, GLY319D, GLY319E, GLY320D, GLY320E, GLY338D, GLY338E, GLY65D, GLY65E, GLY67D, GLY67E, GLY86D, GLY86E, GLY87D, GLY87E, HIS229D, HIS229E, HIS332D, HIS332E, HIS335D, HIS335E, HIS80D, HIS80E, ILE107D, ILE107E, ILE13D, ILE13E, ILE202D, ILE202E, ILE285D, ILE285E, ILE28D, ILE28E, ILE342D, ILE342E, ILE7D, ILE7E, ILE99D, ILE99E, LEU102D, LEU102E, LEU132D, LEU132E, LEU14D, LEU14E, LEU150D, LEU150E, LEU152D, LEU152E, LEU188D, LEU188E, LEU191D, LEU191E, LEU203D, LEU203E, LEU24D, LEU24E, LEU349D, LEU349E, LEU355D, LEU355E, LEU75D, LEU75E, LEU91D, LEU91E, LEU95D, LEU95E, LYS108D, LYS108E, LYS193D, LYS193E, LYS200D, LYS200E, LYS260D, LYS344D, LYS344E, LYS352D, LYS352E, LYS3D, LYS3E, LYS68D, LYS68E, LYS69D, LYS69E, LYS72D, LYS72E, MET206D, MET206E, MET76D, MET76E, MET82D, MET82E, MET83D, MET83E, MET85D, MET85E, PHE100D, PHE100E, PHE105D, PHE105E, PHE141D, PHE141E, PHE17D, PHE17E, PHE183D, PHE183E, PHE289D, PHE289E, PHE315D, PHE315E, PHE336D, PHE336E, PHE339D, PHE339E, PHE343D, PHE343E, PHE354D, PHE354E, PHE62D, PHE62E, PRO101D, PRO101E, PRO104D, PRO104E, PRO157D, PRO157E, PRO18D, PRO18E, PRO254D, PRO254E, PRO347D, PRO347E, PRO350D, PRO350E, PRO93D, PRO93E, SER11D, SER11E, SER15D, SER15E, SER196D, SER196E, SER197D, SER197E, SER2D, SER2E, SER98D, SER98E, THR16D, THR16E, THR186D, THR186E, THR190D, THR190E, THR22D, THR22E, THR258D, THR258E, THR66D, THR66E, THR70D, THR70E, THR78D, THR78E, THR8D, THR8E, THR97D, THR97E, TRP12D, TRP12E, TRP151D, TRP151E, TRP154D, TRP154E, TRP20D, TRP20E, TRP23D, TRP23E, TRP286D, TRP286E, TRP316D, TRP316E, TRP63D, TRP63E, TYR198D, TYR198E, TYR230D, TYR230E, TYR333D, TYR333E, TYR351D, TYR351E, VAL125D, VAL125E, VAL127D, VAL127E, VAL131D, VAL131E, VAL156D, VAL156E, VAL189D, VAL189E, VAL195D, VAL195E, VAL257D, VAL257E, VAL298D, VAL298E, VAL318D, VAL318E, VAL4D, VAL4E, VAL88D, VAL88E
• D-F: ALA235F, ALA353D, ARG185F, ARG268F, ARG294D, ARG306F, ARG330D, ARG337D, ASN232F, ASN239F, ASN301F, ASN345D, ASP181F, ASP184F, ASP204F, ASP207F, ASP240F, ASP305F, ASP341D, GLN308F, GLN317D, GLN334D, GLN340D, GLU271F, GLU297D, GLU346D, GLY205F, GLY238F, GLY329D, HIS229F, HIS237F, HIS332D, HIS335D, ILE202F, ILE342D, LEU180F, LEU188F, LEU203F, LEU307F, LEU349D, LEU355D, LYS200F, LYS236F, LYS303F, LYS304F, LYS344D, LYS352D, MET206F, MET302F, MET331D, PHE183F, PHE311F, PHE314D, PHE315D, PHE339D, PHE343D, PHE354D, PRO347D, PRO350D, SER182F, SER228F, SER231F, SER272F, TYR230F, TYR233F, TYR234F, TYR309F, TYR333D, TYR351D, VAL166F, VAL189F
• E-F: ALA201E, ALA201F, ALA235E, ALA235F, ALA269E, ALA269F, ALA270E, ALA270F, ARG185E, ARG185F, ARG255E, ARG255F, ARG268E, ARG268F, ARG294E, ARG294F, ARG306E, ARG306F, ASN232E, ASN232F, ASN239E, ASN239F, ASN253E, ASN253F, ASN288F, ASN291E, ASN291F, ASN301E, ASN301F, ASP199E, ASP199F, ASP204E, ASP204F, ASP240E, ASP240F, ASP259E, ASP259F, ASP265E, ASP265F, ASP274E, ASP274F, ASP292E, ASP292F, CYS275E, CYS275F, GLN290E, GLN290F, GLU252E, GLU252F, GLU271E, GLU271F, GLU295E, GLU295F, GLU297E, GLU297F, GLY205E, GLY205F, GLY238E, GLY238F, GLY251E, GLY251F, GLY256E, GLY256F, GLY86E, GLY86F, GLY87F, HIS229E, HIS229F, HIS237E, HIS237F, ILE202E, ILE202F, ILE243E, ILE243F, ILE296E, ILE296F, LEU188E, LEU188F, LEU203E, LEU203F, LEU267E, LEU267F, LEU273E, LEU273F, LEU299E, LEU299F, LEU307E, LEU307F, LYS200E, LYS200F, LYS236E, LYS236F, LYS260E, LYS260F, LYS303E, LYS303F, MET261E, MET261F, MET302E, MET302F, MET82E, MET82F, MET85E, MET85F, PHE289E, PHE289F, PHE311E, PHE311F, PRO254E, PRO254F, PRO293E, PRO293F, SER231E, SER231F, SER263E, SER263F, SER264E, SER264F, SER272E, SER272F, THR186E, THR258E, THR258F, THR262E, THR262F, TRP300E, TRP300F, TYR198E, TYR198F, TYR230E, TYR230F, TYR233E, TYR233F, TYR234E, TYR234F, TYR241E, TYR241F, TYR250E, TYR250F, TYR309E, TYR309F, VAL257E, VAL257F, VAL266E, VAL266F, VAL298E, VAL298F, VAL88F