3BUW

crystal structure of c-cbl-tkb domain complexed with its binding motif in syk

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 39
  • Norm. En. per Res.: -2.3555
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-8.0139	-5.8319	-71.1944	-85.0402	39	9	0	2815	0	7	5
B-D	-3.7147	0.0	-137.177	-140.8917	90	3	7	6336	0	16	21
C-D	-19.6188	-5.793	-66.4543	-91.8661	39	16	0	2852	0	7	5

Interface residues

• A-B: ARG294B, ARG299B, ASN321A, ASN79B, ASP275B, ASP86B, CYS297B, GLN316B, GLU276B, GLU324A, GLU326A, GLU334B, GLY306B, HIS320B, ILE305B, ILE314B, ILE318B, LEU315B, LEU327A, LYS278B, LYS78B, PHE320A, PHE336B, PRO319B, PRO322A, PRO325A, PRO81B, PRO82B, SER296B, SER319A, SER80B, THR273B, THR298B, THR309B, THR317B, TYR274B, TYR307B, TYR337B, TYR83B
• B-D: ALA221B, ALA221D, ALA223B, ALA223D, ALA262B, ALA262D, ALA270B, ALA270D, ARG139B, ARG139D, ARG206B, ARG206D, ARG280B, ARG280D, ARG343B, ARG343D, ASN259B, ASN259D, ASP234B, ASP234D, ASP341B, ASP341D, GLN146B, GLN146D, GLU220B, GLU220D, GLY218B, GLY218D, GLY267B, GLY267D, HIS210B, HIS210D, HIS213B, HIS213D, HIS265B, HIS265D, ILE215B, ILE215D, LEU219B, LEU219D, LEU224B, LEU224D, LEU261B, LEU261D, LYS153B, LYS153D, LYS203B, LYS203D, LYS225B, LYS225D, MET222B, MET222D, MET269B, MET269D, PHE244B, PHE244D, PHE248B, PHE248D, PHE271B, PHE271D, PRO201B, PRO214B, PRO214D, PRO266B, PRO266D, PRO340B, PRO340D, PRO347B, PRO347D, PRO47B, PRO47D, SER216B, SER216D, SER217B, SER217D, SER226B, SER226D, THR227B, THR227D, THR264B, THR264D, TRP202B, TRP202D, TRP258B, TRP258D, TYR235D, TYR268B, TYR268D, VAL263B, VAL263D
• C-D: ARG294D, ARG299D, ASN321C, ASN79D, ASP275D, ASP86D, CYS297D, GLN316D, GLU276D, GLU324C, GLU326C, GLU334D, GLY306D, HIS320D, ILE305D, ILE314D, ILE318D, LEU315D, LEU327C, LYS278D, LYS78D, PHE320C, PHE336D, PRO319D, PRO322C, PRO325C, PRO81D, PRO82D, SER296D, SER319C, SER80D, THR273D, THR298D, THR309D, THR317D, TYR274D, TYR307D, TYR337D, TYR83D