3BUO

crystal structure of c-cbl-tkb domain complexed with its binding motif in egf receptor'

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 52
  • Norm. En. per Res.: -2.8192
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-8.1911	-23.9494	-113.425	-145.5655	53	22	0	4855	1	6	7
B-D	-18.0339	-6.3381	-130.833	-155.205	108	6	7	6819	0	28	28
C-D	-8.2993	-24.0693	-114.23	-146.5987	52	23	0	4850	1	6	7

Interface residues

• A-B: ALA327B, ARG1068A, ARG294B, ARG299B, ASN313B, ASN321B, ASN79B, ASP1072A, ASP275B, ASP330B, ASP86B, ASP90B, CYS297B, GLN1067A, GLN316B, GLN326B, GLU276B, GLU334B, GLY306B, GLY331B, GLY335B, HIS320B, ILE305B, ILE314B, ILE318B, LEU1066A, LEU156B, LEU315B, LEU87B, LYS278B, LYS322B, LYS78B, PHE1065A, PHE336B, PRO1073A, PRO319B, PRO81B, PRO82B, SER1064A, SER1070A, SER1071A, SER296B, SER80B, THR1074A, THR273B, THR298B, THR309B, THR317B, TYR274B, TYR307B, TYR337B, TYR83B, VAL277B
• B-D: ALA221B, ALA221D, ALA223B, ALA223D, ALA262B, ALA262D, ALA270B, ALA270D, ARG139B, ARG139D, ARG149B, ARG149D, ARG206B, ARG206D, ARG280B, ARG280D, ARG343B, ARG343D, ASN259B, ASN259D, ASN344B, ASN344D, ASP234B, ASP234D, GLN146B, GLN146D, GLN207B, GLN207D, GLU120B, GLU120D, GLU135B, GLU135D, GLU220B, GLU220D, GLY218B, GLY218D, GLY267B, GLY267D, GLY49B, GLY49D, HIS210B, HIS210D, HIS265B, HIS265D, ILE215B, ILE215D, LEU219B, LEU219D, LEU224B, LEU224D, LEU261B, LEU261D, LYS124B, LYS124D, LYS127B, LYS127D, LYS153B, LYS153D, LYS203B, LYS203D, LYS225B, LYS225D, LYS283B, LYS283D, MET222B, MET222D, MET269B, MET269D, PHE244B, PHE244D, PHE248B, PHE248D, PHE271B, PHE271D, PHE284B, PHE284D, PRO201B, PRO201D, PRO214B, PRO214D, PRO266B, PRO266D, PRO340B, PRO340D, PRO347B, PRO347D, PRO48B, PRO48D, SER131B, SER131D, SER216B, SER216D, SER217B, SER217D, SER226B, SER226D, THR227B, THR227D, THR264B, THR264D, TRP202B, TRP202D, TRP258B, TRP258D, TYR268B, TYR268D, VAL263B, VAL263D
• C-D: ALA327D, ARG1068C, ARG294D, ARG299D, ASN321D, ASN79D, ASP1072C, ASP275D, ASP330D, ASP86D, ASP90D, CYS297D, GLN1067C, GLN316D, GLN326D, GLU276D, GLU334D, GLY306D, GLY331D, GLY335D, HIS320D, ILE305D, ILE314D, ILE318D, LEU1066C, LEU156D, LEU315D, LEU87D, LYS278D, LYS322D, LYS78D, PHE1065C, PHE336D, PRO1073C, PRO319D, PRO81D, PRO82D, SER1064C, SER1070C, SER1071C, SER296D, SER80D, THR1074C, THR273D, THR298D, THR309D, THR317D, TYR274D, TYR307D, TYR337D, TYR83D, VAL277D