3BL2

crystal structure of m11, the bcl-2 homolog of murine gamma- herpesvirus 68, complexed with mouse beclin1 (residues 106- 124)

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 73
  • Norm. En. per Res.: -4.9422
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-6.8888	0.0	-24.2613	-31.1501	11	1	1	715	0	0	1
A-C	-25.7841	-32.1764	-272.641	-330.6015	72	14	7	10645	2	18	23
A-D	-3.5855	2.2919	-36.0609	-37.3545	17	3	1	1646	0	5	7
B-C	-6.6713	13.1564	-32.2381	-25.753	18	2	1	1500	0	7	8
B-D	-48.9004	-32.8104	-279.071	-360.7819	73	17	7	10562	3	20	21
C-D	0.0	0.0	-6.4102	-6.4102	14	1	0	501	0	0	3

Interface residues

• A-B: ALA58A, ALA58B, ARG57A, ARG57B, SER54A, SER54B, TYR52B, TYR56A, TYR56B, VAL55A, VAL55B
• A-C: ALA58A, ALA63A, ARG112C, ARG113C, ARG49A, ARG50A, ARG57A, ARG69A, ARG87A, ASN109C, ASN66A, ASN84A, ASP119C, ASP122C, ASP53A, ASP59A, ASP70A, ASP81A, ASP93A, GLN46A, GLU108C, GLU47A, GLY118C, GLY61A, GLY86A, GLY90A, HIS51A, ILE123C, ILE83A, ILE88A, LEU110C, LEU114C, LEU120C, LEU44A, LEU64A, LEU71A, LEU74A, LEU78A, LYS115C, LYS65A, LYS73A, MET107C, MET124C, PHE121C, PHE132A, PHE48A, PHE75A, PHE79A, PHE91A, PRO62A, SER111C, SER54A, SER72A, SER77A, SER85A, THR106C, THR117C, THR43A, THR45A, THR76A, TRP67A, TYR52A, TYR56A, TYR60A, TYR97A, VAL116C, VAL55A, VAL80A, VAL82A, VAL89A, VAL94A, VAL98A
• A-D: ALA58A, ARG112D, ARG113D, ARG57A, ASN109D, ASP53A, GLU108D, HIS51A, LEU120D, LYS115D, SER54A, THR106D, THR117D, TYR52A, TYR56A, VAL116D, VAL55A
• B-C: ALA58B, ARG112C, ARG113C, ARG50B, ARG57B, ASN109C, ASP119C, ASP53B, GLU108C, HIS51B, LEU120C, SER54B, THR106C, THR117C, TYR52B, TYR56B, VAL116C, VAL55B
• B-D: ALA58B, ALA63B, ARG112D, ARG113D, ARG49B, ARG50B, ARG57B, ARG69B, ARG87B, ASN109D, ASN66B, ASN84B, ASP119D, ASP122D, ASP53B, ASP59B, ASP70B, ASP81B, ASP93B, GLN46B, GLU108D, GLU47B, GLY118D, GLY61B, GLY86B, GLY90B, HIS131B, HIS51B, ILE123D, ILE83B, ILE88B, LEU110D, LEU114D, LEU120D, LEU44B, LEU64B, LEU71B, LEU74B, LEU78B, LYS115D, LYS65B, LYS73B, MET107D, MET124D, PHE121D, PHE132B, PHE48B, PHE75B, PHE79B, PHE91B, PRO62B, SER111D, SER54B, SER72B, SER77B, SER85B, THR106D, THR117D, THR43B, THR45B, THR76B, TRP67B, TYR52B, TYR56B, TYR60B, TYR97B, VAL116D, VAL55B, VAL80B, VAL82B, VAL89B, VAL94B, VAL98B
• C-D: ARG112C, ARG112D, ARG113C, ARG113D, ASN109D, ILE123C, ILE123D, LEU120C, LEU120D, MET124C, MET124D, THR117D, VAL116C, VAL116D