3BFJ

crystal structure analysis of 1,3-propanediol oxidoreductase

• Total interactions analyzed: 190
• Total true interactions: 44
• Strongest Interaction:
  • Chains: I-R
  • Int. Res.: 9
  • Norm. En. per Res.: -4.5506
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-17.5241	-18.6414	-122.821	-158.9865	64	3	4	5342	2	12	17
A-C	0.0	0.0	-0.0015	-0.0015	2	0	0	1	0	0	0
A-D	-106.2151	-7.3918	-472.579	-586.1859	169	27	20	19241	0	24	21
A-F	-14.682	6.0278	-112.354	-121.0081	66	5	4	5288	2	10	16
A-L	0.0	-4.3832	-29.2259	-33.6091	34	3	0	1507	2	19	20
A-O	0.0	0.0	-0.0085	-0.0085	4	0	0	9	0	0	2
B-D	0.0	0.0	-0.0018	-0.0018	2	0	0	1	0	0	0
B-O	-95.4047	-10.0719	-484.52	-589.9967	166	20	21	19731	1	24	21
B-P	0.0	0.0	-0.0521	-0.0521	4	0	0	23	0	0	2
B-Q	-20.3827	6.3404	-119.442	-133.4843	66	4	4	5287	1	11	16
C-D	-16.5028	-27.1645	-108.47	-152.1373	67	4	4	5244	3	11	16
C-F	-98.2703	-25.295	-480.922	-604.4873	171	30	20	19601	1	23	22
C-J	-14.5316	7.1869	-111.015	-118.3597	63	6	4	5266	1	11	16
C-N	0.0	0.0	-0.0192	-0.0192	6	0	0	18	0	0	2
D-F	0.0	0.0	-0.3671	-0.3671	2	0	0	53	0	0	2
D-O	-14.8514	6.3719	-120.944	-129.4236	61	4	4	5190	1	11	17
E-G	-14.6905	-25.4054	-116.398	-156.4938	64	5	4	5272	2	12	16
E-I	-115.2856	-18.4261	-482.146	-615.8577	170	15	20	19464	1	24	22
E-K	-11.256	-31.3506	-117.605	-160.2116	66	8	4	5361	3	9	17
E-R	0.0	0.0	-0.0201	-0.0201	2	0	0	16	0	0	1
F-N	-15.1844	6.8627	-119.649	-127.9707	62	3	4	5241	1	10	16
G-I	0.0	0.0	-0.0451	-0.0451	3	0	0	5	0	0	0
G-R	-118.0063	-13.6413	-298.634	-430.2816	97	15	8	11161	3	7	10
G-T	-14.5969	6.2789			7
H-I	-17.6806	-23.911	-118.309	-159.9007	67	5	4	5442	3	11	17
H-K	-89.338	-19.2693	-480.588	-589.1953	170	16	20	19588	1	23	21
H-L	-23.3067	-23.6148	-122.01	-168.9315	65	7	4	5497	1	10	16
H-M	0.0	0.0	-0.02	-0.02	2	0	0	13	0	0	2
I-K	0.0	0.0	-0.0302	-0.0302	2	0	0	18	0	0	2
I-R	-16.208	-24.7468	-0.0003	-40.9551	9	0	0	1	0	0	0
J-N	-116.7779	-25.5036	-501.868	-644.1495	170	20	20	19973	3	24	22
J-P	-14.0413	7.3803	-112.67	-119.331	63	3	4	5139	1	12	16
J-Q	0.0	0.0	-0.0122	-0.0122	4	0	0	12	0	0	2
K-L	0.0	0.0	-0.0095	-0.0095	2	0	0	1	0	0	0
K-M	-18.9391	8.1357	-115.642	-126.4454	62	4	4	5231	1	10	17
L-M	-115.6731	-21.7007	-478.137	-615.5108	173	16	20	19764	1	24	21
L-S	-16.3368	-26.3158			9
M-T	-16.1121	-25.608			7
N-Q	-12.8673	-30.9673	-121.914	-165.7486	62	2	4	5299	2	11	16
O-P	-15.8946	-26.1173	-117.331	-159.3429	64	5	4	5311	3	11	16
O-Q	0.0	0.0	-0.0118	-0.0118	2	0	0	1	0	0	0
P-Q	-100.9597	-16.9189	-488.22	-606.0987	171	25	21	19842	1	24	22
R-S	-20.6467	-27.0388			9
S-T	-53.8879	-20.4559			16

Interface residues

• A-B: ALA189B, ALA190B, ALA193B, ALA228B, ALA234B, ALA236B, ALA243B, ALA299A, ALA323A, ALA324A, ALA330B, ARG229B, ARG232B, ARG294A, ARG333B, ARG372A, ASN230B, ASN240B, ASN296A, ASN300A, ASN314B, ASN370A, ASN375A, ASP322A, ASP337B, GLN233B, GLU302A, GLU313B, GLU325A, GLU378A, GLY238B, GLY312B, GLY317A, GLY339B, GLY374A, ILE208A, ILE298A, ILE315B, ILE338B, LEU231B, LEU237B, LEU297A, LEU318A, LEU321A, LEU334B, LYS210A, LYS326B, LYS373A, MET311B, MET336B, PHE368A, PRO188B, PRO301A, PRO371A, SER209A, SER239B, SER319A, SER369A, THR316A, THR316B, THR320A, TYR265A, TYR295A, VAL235B
• A-C: GLN242C, TYR246A
• A-D: ALA20A, ALA20D, ALA212A, ALA212D, ALA218A, ALA218D, ALA219A, ALA219D, ALA220A, ALA220D, ALA223A, ALA223D, ALA248A, ALA248D, ALA250A, ALA250D, ALA254A, ALA254D, ALA261D, ARG152A, ARG152D, ARG171A, ARG171D, ARG225A, ARG225D, ARG229A, ARG229D, ARG27A, ARG27D, ARG4A, ARG4D, ASN12A, ASN12D, ASN132A, ASN132D, ASN14A, ASN14D, ASN172D, ASN179A, ASN179D, ASN19A, ASN19D, ASN213A, ASN213D, ASN230A, ASN230D, ASN260A, ASN260D, ASN314A, ASN314D, ASP180A, ASP180D, ASP211A, ASP211D, ASP217A, ASP217D, ASP306A, ASP306D, ASP7A, ASP7D, GLN222A, GLN222D, GLN242A, GLN242D, GLN29A, GLN29D, GLU128A, GLU128D, GLU245A, GLU245D, GLU26A, GLU26D, GLU309A, GLU309D, GLY17A, GLY17D, GLY32A, GLY32D, ILE178A, ILE178D, ILE21A, ILE21D, LEU130A, LEU130D, LEU173A, LEU173D, LEU182A, LEU182D, LEU226A, LEU226D, LEU241A, LEU241D, LEU252A, LEU252D, LEU253A, LEU253D, LEU30A, LEU30D, LEU310A, LEU310D, LEU31A, LEU31D, LEU9A, LEU9D, LYS303A, LYS303D, MET221A, MET221D, MET256A, MET256D, MET5A, MET5D, PHE15A, PHE15D, PHE16A, PHE16D, PHE6A, PHE6D, PRO11A, PRO11D, PRO133A, PRO133D, PRO136A, PRO136D, PRO174A, PRO174D, PRO181A, PRO181D, PRO18A, PRO18D, PRO214A, PRO214D, SER169A, SER169D, SER175A, SER175D, SER177A, SER177D, SER22A, SER22D, SER251D, THR131A, THR131D, THR216A, THR216D, THR316A, THR316D, TRP170A, TRP170D, TYR207A, TYR207D, TYR246A, TYR246D, TYR249A, TYR249D, TYR8A, TYR8D, VAL10A, VAL10D, VAL13A, VAL13D, VAL150A, VAL150D, VAL176A, VAL176D, VAL215A, VAL215D, VAL23A, VAL23D
• A-F: ALA189A, ALA228A, ALA234A, ALA236A, ALA243A, ALA299F, ALA323F, ALA324F, ALA330A, ARG229A, ARG232A, ARG294F, ARG333A, ARG372F, ARG4F, ASN230A, ASN240A, ASN296F, ASN300F, ASN314A, ASN370F, ASN375F, ASP322F, ASP337A, GLN233A, GLU302F, GLU313A, GLU325F, GLU378F, GLY186A, GLY238A, GLY312A, GLY317F, GLY339A, GLY374F, ILE208F, ILE298F, ILE315A, ILE315F, ILE338A, LEU231A, LEU237A, LEU241A, LEU297F, LEU318F, LEU321F, LEU334A, LYS210F, LYS326A, LYS373F, MET311A, MET336A, PHE368F, PRO188A, PRO301F, PRO371F, SER209F, SER239A, SER319F, SER369F, THR316A, THR316F, THR320F, TYR265F, TYR295F, VAL235A
• A-L: ALA358L, ALA380L, ALA62A, ALA67A, ARG384L, ARG45A, ARG60A, ARG90A, ASP353L, ASP53A, GLN377L, GLU351L, GLU359L, GLU376L, GLU61A, GLU65A, GLU91A, GLY63A, HIS57A, ILE64A, ILE68A, LEU56A, LEU59A, LYS350L, LYS35A, LYS363L, MET357L, MET360L, PHE354L, PRO355L, THR352L, TYR356L, VAL66A, VAL87A
• A-O: ARG4A, ARG4O, GLY317A, THR316O
• B-D: GLN242B, GLN242D
• B-O: ALA20B, ALA20O, ALA212B, ALA212O, ALA218B, ALA218O, ALA219B, ALA219O, ALA220B, ALA220O, ALA223B, ALA223O, ALA248B, ALA248O, ALA250B, ALA250O, ALA254B, ALA254O, ARG152B, ARG152O, ARG171B, ARG171O, ARG225B, ARG225O, ARG229B, ARG229O, ARG27B, ARG27O, ARG4B, ARG4O, ASN12B, ASN12O, ASN132B, ASN132O, ASN14B, ASN14O, ASN172O, ASN179B, ASN179O, ASN19B, ASN19O, ASN213B, ASN213O, ASN230B, ASN230O, ASN260B, ASN260O, ASN314B, ASN314O, ASP180B, ASP180O, ASP211B, ASP211O, ASP217B, ASP217O, ASP306B, ASP306O, ASP7B, ASP7O, GLN222B, GLN222O, GLN242B, GLN242O, GLN29B, GLN29O, GLU128B, GLU128O, GLU245B, GLU245O, GLU26O, GLU309B, GLU309O, GLY17B, GLY17O, GLY32B, GLY32O, ILE178B, ILE178O, ILE21B, ILE21O, LEU130B, LEU130O, LEU173B, LEU173O, LEU182B, LEU182O, LEU226B, LEU226O, LEU241B, LEU241O, LEU252B, LEU252O, LEU253B, LEU253O, LEU30B, LEU30O, LEU310B, LEU310O, LEU31B, LEU31O, LEU9B, LEU9O, MET221B, MET221O, MET247B, MET256B, MET256O, MET5B, MET5O, PHE15B, PHE15O, PHE16B, PHE16O, PHE6B, PHE6O, PRO11B, PRO11O, PRO133B, PRO133O, PRO136B, PRO136O, PRO174B, PRO174O, PRO181B, PRO181O, PRO18B, PRO18O, PRO214B, PRO214O, SER169B, SER169O, SER175B, SER175O, SER177B, SER177O, SER22B, SER22O, SER251B, THR131B, THR131O, THR216B, THR216O, THR316B, THR316O, TRP170B, TRP170O, TYR207B, TYR207O, TYR246B, TYR246O, TYR249B, TYR249O, TYR8B, TYR8O, VAL10B, VAL10O, VAL13B, VAL13O, VAL150B, VAL150O, VAL176B, VAL176O, VAL215B, VAL215O, VAL23B, VAL23O
• B-P: ARG4B, ARG4P, THR316B, THR316P
• B-Q: ALA189Q, ALA190Q, ALA193Q, ALA228Q, ALA234Q, ALA236Q, ALA243Q, ALA299B, ALA323B, ALA324B, ALA330Q, ARG229Q, ARG232Q, ARG294B, ARG333Q, ARG372B, ARG4B, ASN230Q, ASN240Q, ASN296B, ASN300B, ASN314Q, ASN370B, ASN375B, ASP322B, ASP337Q, GLN233Q, GLN242Q, GLU302B, GLU313Q, GLU325B, GLU378B, GLY238Q, GLY312Q, GLY317B, GLY339Q, GLY374B, ILE208B, ILE298B, ILE315B, ILE338Q, LEU231Q, LEU237Q, LEU241Q, LEU297B, LEU318B, LEU321B, LEU334Q, LYS210B, LYS326Q, LYS373B, MET311Q, MET336Q, PHE368B, PRO301B, PRO371B, SER209B, SER239Q, SER319B, SER369B, THR316B, THR316Q, THR320B, TYR265B, TYR295B, VAL235Q
• C-D: ALA189C, ALA190C, ALA228C, ALA234C, ALA236C, ALA243C, ALA299D, ALA323D, ALA324D, ALA330C, ARG229C, ARG232C, ARG294D, ARG333C, ARG372D, ARG4D, ASN230C, ASN240C, ASN296D, ASN300D, ASN314C, ASN370D, ASN375D, ASP322D, ASP337C, GLN233C, GLN242C, GLU302D, GLU313C, GLU325D, GLU378D, GLY238C, GLY312C, GLY317D, GLY339C, GLY374D, ILE208D, ILE298D, ILE315C, ILE315D, ILE338C, LEU231C, LEU237C, LEU241C, LEU297D, LEU318D, LEU321D, LEU334C, LYS210D, LYS326C, LYS373D, MET311C, MET336C, PHE368D, PRO188C, PRO301D, PRO371D, SER209D, SER239C, SER319D, SER369D, THR316C, THR316D, THR320D, TYR265D, TYR295D, VAL235C
• C-F: ALA20C, ALA20F, ALA212C, ALA212F, ALA218C, ALA218F, ALA219C, ALA219F, ALA220C, ALA220F, ALA223C, ALA223F, ALA248C, ALA248F, ALA250C, ALA250F, ALA254C, ALA254F, ALA261F, ARG152C, ARG152F, ARG171C, ARG171F, ARG225C, ARG225F, ARG229C, ARG229F, ARG27C, ARG27F, ARG4C, ARG4F, ASN12C, ASN12F, ASN132C, ASN132F, ASN14C, ASN14F, ASN172C, ASN179C, ASN179F, ASN19C, ASN19F, ASN213C, ASN213F, ASN230C, ASN230F, ASN260C, ASN260F, ASN314C, ASN314F, ASP180C, ASP180F, ASP211C, ASP211F, ASP217C, ASP217F, ASP306C, ASP306F, ASP7C, ASP7F, GLN222C, GLN222F, GLN242C, GLN29C, GLN29F, GLU128C, GLU128F, GLU245C, GLU245F, GLU26C, GLU26F, GLU309C, GLU309F, GLY17C, GLY17F, GLY32C, GLY32F, ILE178C, ILE178F, ILE21C, ILE21F, LEU130C, LEU130F, LEU173C, LEU173F, LEU182C, LEU182F, LEU226C, LEU226F, LEU241C, LEU241F, LEU252C, LEU252F, LEU253C, LEU253F, LEU30C, LEU30F, LEU310C, LEU310F, LEU31C, LEU31F, LEU9C, LEU9F, LYS303C, LYS303F, MET221C, MET221F, MET247C, MET256C, MET256F, MET5C, MET5F, PHE15C, PHE15F, PHE16C, PHE16F, PHE6C, PHE6F, PRO11C, PRO11F, PRO133C, PRO133F, PRO136C, PRO174C, PRO174F, PRO181C, PRO181F, PRO18C, PRO18F, PRO214C, PRO214F, SER169C, SER169F, SER175C, SER175F, SER177C, SER177F, SER22C, SER22F, SER251C, SER251F, THR129C, THR131C, THR131F, THR216C, THR216F, THR316C, THR316F, TRP170C, TRP170F, TYR207C, TYR207F, TYR246C, TYR246F, TYR249C, TYR249F, TYR8C, TYR8F, VAL10C, VAL10F, VAL13C, VAL13F, VAL150C, VAL150F, VAL176C, VAL176F, VAL215C, VAL215F, VAL23C, VAL23F, VAL24C
• C-J: ALA189J, ALA190J, ALA228J, ALA234J, ALA236J, ALA243J, ALA299C, ALA323C, ALA324C, ALA330J, ARG229J, ARG232J, ARG333J, ARG372C, ARG4C, ASN230J, ASN240J, ASN296C, ASN300C, ASN314J, ASN370C, ASN375C, ASP322C, ASP337J, GLN233J, GLN242J, GLU302C, GLU313J, GLU325C, GLU378C, GLY238J, GLY312J, GLY317C, GLY339J, GLY374C, ILE298C, ILE315C, ILE315J, ILE338J, LEU231J, LEU237J, LEU241J, LEU297C, LEU318C, LEU321C, LEU334J, LYS210C, LYS326J, LYS373C, MET311J, MET336J, PHE368C, PRO188J, PRO301C, PRO371C, SER239J, SER319C, SER369C, THR316C, THR316J, THR320C, TYR295C, VAL235J
• C-N: ARG4C, ARG4N, GLY317C, GLY317N, THR316C, THR316N
• D-F: ARG4D, ARG4F
• D-O: ALA189D, ALA228D, ALA234D, ALA236D, ALA243D, ALA299O, ALA323O, ALA324O, ALA330D, ARG229D, ARG232D, ARG294O, ARG333D, ARG372O, ASN230D, ASN240D, ASN296O, ASN300O, ASN314D, ASN370O, ASN375O, ASP322O, ASP337D, GLN233D, GLN242D, GLU302O, GLU313D, GLU325O, GLU378O, GLY238D, GLY312D, GLY317O, GLY339D, GLY374O, ILE208O, ILE298O, ILE315D, ILE338D, LEU231D, LEU237D, LEU297O, LEU318O, LEU321O, LEU334D, LYS210O, LYS326D, LYS373O, MET311D, MET336D, PHE368O, PRO188D, PRO301O, PRO371O, SER239D, SER319O, SER369O, THR316D, THR316O, THR320O, TYR295O, VAL235D
• E-G: ALA189G, ALA193G, ALA228G, ALA234G, ALA236G, ALA243G, ALA299E, ALA323E, ALA324E, ALA330G, ARG229G, ARG232G, ARG294E, ARG333G, ARG372E, ARG4E, ASN230G, ASN240G, ASN296E, ASN300E, ASN314G, ASN370E, ASP322E, ASP337G, GLN233G, GLU302E, GLU313G, GLU325E, GLU378E, GLY238G, GLY312G, GLY317E, GLY339G, GLY374E, ILE208E, ILE298E, ILE315G, ILE338G, LEU231G, LEU237G, LEU241G, LEU297E, LEU318E, LEU321E, LEU334G, LYS210E, LYS326G, LYS373E, MET311G, MET336G, PHE368E, PRO188G, PRO301E, PRO371E, SER209E, SER239G, SER319E, SER369E, THR316E, THR316G, THR320E, TYR265E, TYR295E, VAL235G
• E-I: ALA20E, ALA20I, ALA212E, ALA212I, ALA218E, ALA218I, ALA219E, ALA219I, ALA220E, ALA220I, ALA223E, ALA223I, ALA248E, ALA248I, ALA250E, ALA250I, ALA254E, ALA254I, ALA261E, ARG152E, ARG152I, ARG171E, ARG171I, ARG225E, ARG225I, ARG229E, ARG229I, ARG27E, ARG27I, ARG4E, ARG4I, ASN12E, ASN12I, ASN132E, ASN132I, ASN14E, ASN14I, ASN172I, ASN179E, ASN179I, ASN19E, ASN19I, ASN213E, ASN213I, ASN230E, ASN230I, ASN260E, ASN260I, ASN314E, ASN314I, ASP180E, ASP180I, ASP211E, ASP211I, ASP217E, ASP217I, ASP306E, ASP306I, ASP7E, ASP7I, GLN222E, GLN222I, GLN242E, GLN242I, GLN29E, GLN29I, GLU128E, GLU128I, GLU245E, GLU245I, GLU26E, GLU26I, GLU309E, GLU309I, GLY17E, GLY17I, GLY32E, GLY32I, ILE178E, ILE178I, ILE21E, ILE21I, LEU130E, LEU130I, LEU173E, LEU173I, LEU182E, LEU182I, LEU226E, LEU226I, LEU241E, LEU241I, LEU252E, LEU252I, LEU253E, LEU253I, LEU30E, LEU30I, LEU310E, LEU310I, LEU31E, LEU31I, LEU9E, LEU9I, LYS303E, MET221E, MET221I, MET256E, MET256I, MET5E, MET5I, PHE15E, PHE15I, PHE16E, PHE16I, PHE6E, PHE6I, PRO11E, PRO11I, PRO133E, PRO133I, PRO136E, PRO136I, PRO174E, PRO174I, PRO181E, PRO181I, PRO18E, PRO18I, PRO214E, PRO214I, SER169E, SER169I, SER175E, SER175I, SER177E, SER177I, SER22E, SER22I, SER251E, SER251I, THR131E, THR131I, THR216E, THR216I, THR316E, THR316I, TRP170E, TRP170I, TYR207E, TYR207I, TYR246E, TYR246I, TYR249E, TYR249I, TYR8E, TYR8I, VAL10E, VAL10I, VAL13E, VAL13I, VAL150E, VAL150I, VAL176E, VAL176I, VAL215E, VAL215I, VAL23E, VAL23I, VAL24E
• E-K: ALA189E, ALA193E, ALA228E, ALA234E, ALA236E, ALA243E, ALA299K, ALA323K, ALA324K, ALA330E, ARG229E, ARG232E, ARG294K, ARG333E, ARG372K, ARG4K, ASN230E, ASN240E, ASN296K, ASN300K, ASN314E, ASN370K, ASN375K, ASP322K, ASP337E, GLN233E, GLN242E, GLU302K, GLU313E, GLU325K, GLU378K, GLY186E, GLY238E, GLY312E, GLY317K, GLY339E, GLY374K, ILE298K, ILE315E, ILE315K, ILE338E, LEU231E, LEU237E, LEU241E, LEU297K, LEU318K, LEU321K, LEU334E, LYS210K, LYS326E, LYS373K, MET311E, MET336E, PHE368K, PRO188E, PRO301K, PRO371K, SER209K, SER239E, SER319K, SER369K, THR316E, THR316K, THR320K, TYR295K, VAL235E
• E-R: ARG4E, ARG4R
• F-N: ALA189F, ALA190F, ALA228F, ALA234F, ALA236F, ALA243F, ALA299N, ALA323N, ALA324N, ALA330F, ARG229F, ARG232F, ARG294N, ARG333F, ARG372N, ASN230F, ASN240F, ASN296N, ASN300N, ASN314F, ASN370N, ASN375N, ASP322N, ASP337F, GLN233F, GLU302N, GLU313F, GLU325N, GLU378N, GLY238F, GLY312F, GLY317N, GLY339F, GLY374N, ILE298N, ILE315F, ILE338F, LEU231F, LEU237F, LEU297N, LEU318N, LEU321N, LEU334F, LYS187F, LYS210N, LYS303N, LYS326F, LYS373N, MET311F, MET336F, PHE368N, PRO188F, PRO301N, PRO371N, SER239F, SER319N, SER369N, THR316F, THR316N, THR320N, TYR295N, VAL235F
• G-I: GLN242G, GLN242I, TYR246I
• G-R: ALA20G, ALA20R, ALA212G, ALA219G, ARG152G, ARG152R, ARG171G, ARG171R, ARG225G, ARG225R, ARG27G, ARG27R, ARG4G, ARG4R, ASN12G, ASN12R, ASN132G, ASN132R, ASN14G, ASN14R, ASN172G, ASN179G, ASN19G, ASN19R, ASN213G, ASN260G, ASP180G, ASP211G, ASP217G, ASP217R, ASP7G, ASP7R, GLN29R, GLU128G, GLU128R, GLU245G, GLU26G, GLU26R, GLY17G, GLY17R, GLY32R, ILE178G, ILE21G, ILE21R, LEU130G, LEU130R, LEU173G, LEU182G, LEU241G, LEU252G, LEU253G, LEU30G, LEU30R, LEU31G, LEU31R, LEU9G, LEU9R, MET256G, MET5G, MET5R, PHE15G, PHE15R, PHE16G, PHE16R, PHE6G, PHE6R, PRO11G, PRO11R, PRO133G, PRO133R, PRO174G, PRO181G, PRO18G, PRO18R, PRO214G, SER169G, SER175G, SER177G, SER22G, SER22R, THR131G, THR131R, THR216G, TRP170G, TYR249G, TYR8G, TYR8R, VAL10G, VAL10R, VAL13G, VAL13R, VAL150G, VAL150R, VAL176G, VAL215G, VAL23G, VAL23R
• G-T: ALA236T, ARG229T, ARG333T, ASP322G, GLU302G, GLU313T, LYS373G
• H-I: ALA189H, ALA190H, ALA228H, ALA234H, ALA236H, ALA243H, ALA299I, ALA323I, ALA324I, ALA330H, ARG229H, ARG232H, ARG294I, ARG333H, ARG372I, ARG4I, ASN230H, ASN240H, ASN296I, ASN300I, ASN314H, ASN370I, ASN375I, ASP322I, ASP337H, GLN233H, GLN242H, GLU302I, GLU313H, GLU325I, GLU378I, GLY186H, GLY238H, GLY312H, GLY317I, GLY339H, GLY374I, ILE208I, ILE298I, ILE315H, ILE338H, LEU231H, LEU237H, LEU241H, LEU297I, LEU318I, LEU321I, LEU334H, LYS210I, LYS326H, LYS373I, MET311H, MET336H, PHE368I, PRO188H, PRO301I, PRO371I, SER209I, SER239H, SER319I, SER369I, THR316H, THR316I, THR320I, TYR265I, TYR295I, VAL235H
• H-K: ALA20H, ALA20K, ALA212H, ALA212K, ALA218H, ALA218K, ALA219H, ALA219K, ALA220H, ALA220K, ALA223H, ALA223K, ALA248H, ALA248K, ALA250H, ALA250K, ALA254H, ALA254K, ALA261H, ALA261K, ARG152H, ARG152K, ARG171H, ARG171K, ARG225H, ARG225K, ARG229H, ARG229K, ARG27H, ARG27K, ARG4H, ARG4K, ASN12H, ASN12K, ASN14H, ASN14K, ASN172H, ASN172K, ASN179H, ASN179K, ASN19H, ASN19K, ASN213H, ASN213K, ASN230H, ASN230K, ASN260H, ASN260K, ASN314H, ASN314K, ASP180H, ASP180K, ASP211H, ASP211K, ASP217H, ASP217K, ASP306H, ASP306K, ASP7H, ASP7K, GLN222H, GLN222K, GLN242H, GLN242K, GLN29H, GLN29K, GLU128H, GLU128K, GLU245H, GLU245K, GLU26H, GLU26K, GLU309H, GLU309K, GLY17H, GLY17K, GLY32H, GLY32K, ILE178H, ILE178K, ILE21H, ILE21K, LEU130H, LEU130K, LEU173H, LEU173K, LEU182H, LEU182K, LEU226H, LEU226K, LEU241H, LEU241K, LEU252H, LEU252K, LEU253H, LEU253K, LEU30H, LEU30K, LEU310H, LEU310K, LEU31H, LEU31K, LEU9H, LEU9K, LYS303H, LYS303K, MET221H, MET221K, MET256H, MET256K, MET5H, MET5K, PHE15H, PHE15K, PHE16H, PHE16K, PHE6H, PHE6K, PRO11H, PRO11K, PRO133H, PRO133K, PRO136K, PRO174H, PRO174K, PRO181H, PRO181K, PRO18H, PRO18K, PRO214H, PRO214K, SER169H, SER169K, SER175H, SER175K, SER177H, SER177K, SER22H, SER22K, SER251H, SER251K, THR131H, THR131K, THR216H, THR216K, THR316H, THR316K, TRP170H, TRP170K, TYR207H, TYR207K, TYR246H, TYR246K, TYR249H, TYR249K, TYR58K, TYR8H, TYR8K, VAL10H, VAL10K, VAL13H, VAL13K, VAL150H, VAL150K, VAL176H, VAL176K, VAL215H, VAL215K, VAL23H, VAL23K
• H-L: ALA189L, ALA193L, ALA228L, ALA234L, ALA236L, ALA243L, ALA299H, ALA323H, ALA324H, ALA330L, ARG229L, ARG232L, ARG294H, ARG333L, ARG372H, ASN230L, ASN240L, ASN296H, ASN300H, ASN314L, ASN370H, ASN375H, ASP322H, ASP337L, GLN233L, GLN242L, GLU302H, GLU313L, GLU325H, GLU378H, GLY238L, GLY312L, GLY317H, GLY339L, GLY374H, ILE208H, ILE298H, ILE315H, ILE315L, ILE338L, LEU231L, LEU237L, LEU297H, LEU318H, LEU321H, LEU334L, LYS210H, LYS326L, LYS373H, MET311L, MET336L, PHE368H, PRO188L, PRO301H, PRO371H, SER209H, SER239L, SER319H, SER369H, THR316H, THR316L, THR320H, TYR265H, TYR295H, VAL235L
• H-M: ARG4H, ARG4M
• I-K: ARG4I, ARG4K
• I-R: ALA236I, ARG229I, ARG333I, ARG4R, ASP322R, GLU302R, GLU313I, LEU241I, LYS373R
• J-N: ALA20J, ALA20N, ALA212J, ALA212N, ALA218J, ALA218N, ALA219J, ALA219N, ALA220J, ALA220N, ALA223J, ALA223N, ALA248J, ALA248N, ALA250J, ALA250N, ALA254J, ALA254N, ALA261J, ALA261N, ARG152J, ARG152N, ARG171J, ARG171N, ARG225J, ARG225N, ARG229J, ARG229N, ARG27J, ARG27N, ARG4J, ARG4N, ASN12J, ASN12N, ASN132J, ASN132N, ASN14J, ASN14N, ASN172J, ASN179J, ASN179N, ASN19J, ASN19N, ASN213J, ASN213N, ASN230J, ASN230N, ASN260J, ASN260N, ASN314J, ASP180J, ASP180N, ASP211J, ASP211N, ASP217J, ASP217N, ASP306J, ASP306N, ASP7J, ASP7N, GLN222J, GLN222N, GLN242J, GLN242N, GLN29J, GLN29N, GLU128J, GLU128N, GLU245J, GLU245N, GLU26J, GLU26N, GLU309J, GLU309N, GLY17J, GLY17N, GLY32J, GLY32N, ILE178J, ILE178N, ILE21J, ILE21N, LEU130J, LEU130N, LEU173J, LEU173N, LEU182J, LEU182N, LEU226J, LEU226N, LEU241J, LEU241N, LEU252J, LEU252N, LEU253J, LEU253N, LEU30J, LEU30N, LEU310J, LEU310N, LEU31J, LEU31N, LEU9J, LEU9N, LYS303J, MET221J, MET221N, MET247J, MET256J, MET256N, MET5J, MET5N, PHE15J, PHE15N, PHE16J, PHE16N, PHE6J, PHE6N, PRO11J, PRO11N, PRO133J, PRO133N, PRO136J, PRO136N, PRO174J, PRO174N, PRO181J, PRO181N, PRO18J, PRO18N, PRO214J, PRO214N, SER169J, SER169N, SER175J, SER175N, SER177J, SER177N, SER22J, SER22N, SER251J, THR131J, THR131N, THR216J, THR216N, THR316J, THR316N, TRP170J, TRP170N, TYR207J, TYR207N, TYR246J, TYR246N, TYR249J, TYR249N, TYR8J, TYR8N, VAL10J, VAL10N, VAL13J, VAL13N, VAL150J, VAL150N, VAL176J, VAL176N, VAL215J, VAL215N, VAL23J, VAL23N, VAL24J
• J-P: ALA189P, ALA190P, ALA228P, ALA234P, ALA236P, ALA243P, ALA299J, ALA323J, ALA324J, ALA330P, ARG229P, ARG232P, ARG294J, ARG333P, ARG372J, ARG4J, ASN230P, ASN240P, ASN296J, ASN300J, ASN314P, ASN370J, ASN375J, ASP322J, ASP337P, GLN233P, GLN242P, GLU302J, GLU313P, GLU325J, GLU378J, GLY238P, GLY312P, GLY317J, GLY339P, GLY374J, ILE298J, ILE315P, ILE338P, LEU231P, LEU237P, LEU241P, LEU297J, LEU318J, LEU321J, LEU334P, LYS210J, LYS326P, LYS373J, MET311P, MET336P, PHE368J, PRO188P, PRO301J, PRO371J, SER239P, SER319J, SER369J, THR316J, THR316P, THR320J, TYR295J, VAL235P
• J-Q: ARG4J, ARG4Q, GLY317Q, THR316J
• K-L: GLN242K, GLN242L
• K-M: ALA189K, ALA228K, ALA234K, ALA236K, ALA243K, ALA299M, ALA323M, ALA324M, ALA330K, ARG229K, ARG232K, ARG294M, ARG333K, ARG372M, ARG4M, ASN230K, ASN240K, ASN296M, ASN300M, ASN314K, ASN370M, ASN375M, ASP322M, ASP337K, GLN233K, GLU302M, GLU313K, GLU325M, GLU378M, GLY238K, GLY312K, GLY317M, GLY339K, GLY374M, ILE298M, ILE315K, ILE338K, LEU231K, LEU237K, LEU241K, LEU297M, LEU318M, LEU321M, LEU334K, LYS210M, LYS326K, LYS373M, MET311K, MET336K, PHE368M, PRO188K, PRO301M, PRO371M, SER209M, SER239K, SER319M, SER369M, THR316K, THR316M, THR320M, TYR295M, VAL235K
• L-M: ALA20L, ALA20M, ALA212L, ALA212M, ALA218L, ALA218M, ALA219L, ALA219M, ALA220L, ALA220M, ALA223L, ALA223M, ALA248L, ALA248M, ALA250L, ALA250M, ALA254L, ALA254M, ALA261L, ALA261M, ARG152L, ARG152M, ARG171L, ARG171M, ARG225L, ARG225M, ARG229L, ARG229M, ARG27L, ARG27M, ARG4L, ARG4M, ASN12L, ASN12M, ASN132L, ASN132M, ASN14L, ASN14M, ASN172M, ASN179L, ASN179M, ASN19L, ASN19M, ASN213L, ASN213M, ASN230L, ASN230M, ASN260L, ASN260M, ASN314L, ASN314M, ASP180L, ASP180M, ASP211L, ASP211M, ASP217L, ASP217M, ASP306L, ASP306M, ASP7L, ASP7M, GLN222L, GLN222M, GLN242L, GLN242M, GLN29L, GLN29M, GLU128L, GLU128M, GLU245L, GLU245M, GLU26L, GLU26M, GLU309L, GLU309M, GLY17L, GLY17M, GLY32L, GLY32M, ILE178L, ILE178M, ILE21L, ILE21M, LEU130L, LEU130M, LEU173L, LEU173M, LEU182L, LEU182M, LEU226L, LEU226M, LEU241L, LEU241M, LEU252L, LEU252M, LEU253L, LEU253M, LEU30L, LEU30M, LEU310L, LEU310M, LEU31L, LEU31M, LEU9L, LEU9M, LYS303L, LYS303M, MET221L, MET221M, MET247L, MET256L, MET256M, MET5L, MET5M, PHE15L, PHE15M, PHE16L, PHE16M, PHE6L, PHE6M, PRO11L, PRO11M, PRO133L, PRO133M, PRO136L, PRO136M, PRO174L, PRO174M, PRO181L, PRO181M, PRO18L, PRO18M, PRO214L, PRO214M, SER169L, SER169M, SER175L, SER175M, SER177L, SER177M, SER22L, SER22M, SER251L, SER251M, THR131L, THR131M, THR216L, THR216M, THR316L, THR316M, TRP170L, TRP170M, TYR207L, TYR207M, TYR246L, TYR246M, TYR249L, TYR249M, TYR58M, TYR8L, TYR8M, VAL10L, VAL10M, VAL13L, VAL13M, VAL150L, VAL150M, VAL176L, VAL176M, VAL215L, VAL215M, VAL23L, VAL23M
• L-S: ALA236S, ARG229S, ARG333S, ASN314S, ASP322L, GLU302L, GLU313S, GLY317L, LYS373L
• M-T: ALA236M, ARG229M, ARG333M, ASP322T, GLU302T, GLU313M, LYS373T
• N-Q: ALA189N, ALA190N, ALA228N, ALA234N, ALA236N, ALA243N, ALA299Q, ALA323Q, ALA324Q, ALA330N, ARG229N, ARG232N, ARG294Q, ARG333N, ARG372Q, ASN230N, ASN240N, ASN296Q, ASN300Q, ASN314N, ASN370Q, ASN375Q, ASP322Q, ASP337N, GLN233N, GLN242N, GLU302Q, GLU313N, GLU325Q, GLU378Q, GLY238N, GLY312N, GLY317Q, GLY339N, GLY374Q, ILE208Q, ILE298Q, ILE315N, ILE338N, LEU231N, LEU237N, LEU297Q, LEU318Q, LEU321Q, LEU334N, LYS210Q, LYS326N, LYS373Q, MET311N, MET336N, PHE368Q, PRO188N, PRO301Q, PRO371Q, SER239N, SER319Q, SER369Q, THR316N, THR316Q, THR320Q, TYR295Q, VAL235N
• O-P: ALA189O, ALA228O, ALA234O, ALA236O, ALA243O, ALA299P, ALA323P, ALA324P, ALA330O, ARG229O, ARG232O, ARG294P, ARG333O, ARG372P, ARG4P, ASN230O, ASN240O, ASN296P, ASN300P, ASN314O, ASN370P, ASN375P, ASP322P, ASP337O, GLN233O, GLU302P, GLU313O, GLU325P, GLU378P, GLY186O, GLY238O, GLY312O, GLY317P, GLY339O, GLY374P, ILE208P, ILE298P, ILE315O, ILE338O, LEU231O, LEU237O, LEU241O, LEU297P, LEU318P, LEU321P, LEU334O, LYS210P, LYS326O, LYS373P, MET311O, MET336O, PHE368P, PRO188O, PRO301P, PRO371P, SER209P, SER239O, SER319P, SER369P, THR316O, THR316P, THR320P, TYR295P, VAL235O
• O-Q: GLN242O, GLN242Q
• P-Q: ALA20P, ALA20Q, ALA212P, ALA212Q, ALA218P, ALA218Q, ALA219P, ALA219Q, ALA220P, ALA220Q, ALA223P, ALA223Q, ALA248P, ALA248Q, ALA250P, ALA250Q, ALA254P, ALA254Q, ALA261P, ARG152P, ARG152Q, ARG171P, ARG171Q, ARG225P, ARG225Q, ARG229P, ARG229Q, ARG27P, ARG27Q, ARG4P, ARG4Q, ASN12P, ASN12Q, ASN132Q, ASN14P, ASN14Q, ASN172P, ASN172Q, ASN179P, ASN179Q, ASN19P, ASN19Q, ASN213P, ASN213Q, ASN230P, ASN230Q, ASN260P, ASN260Q, ASN314P, ASP180P, ASP180Q, ASP211P, ASP211Q, ASP217P, ASP217Q, ASP306P, ASP306Q, ASP7P, ASP7Q, GLN222P, GLN222Q, GLN242P, GLN29P, GLN29Q, GLU128P, GLU128Q, GLU245P, GLU245Q, GLU26P, GLU26Q, GLU309P, GLU309Q, GLY17P, GLY17Q, GLY32P, GLY32Q, ILE178P, ILE178Q, ILE21P, ILE21Q, LEU130P, LEU130Q, LEU173P, LEU173Q, LEU182P, LEU182Q, LEU226P, LEU226Q, LEU241P, LEU241Q, LEU252P, LEU252Q, LEU253P, LEU253Q, LEU30P, LEU30Q, LEU310P, LEU310Q, LEU31P, LEU31Q, LEU9P, LEU9Q, LYS303P, LYS303Q, MET221P, MET221Q, MET247Q, MET256P, MET256Q, MET5P, MET5Q, PHE15P, PHE15Q, PHE16P, PHE16Q, PHE6P, PHE6Q, PRO11P, PRO11Q, PRO133P, PRO133Q, PRO136P, PRO136Q, PRO174P, PRO174Q, PRO181P, PRO181Q, PRO18P, PRO18Q, PRO214P, PRO214Q, SER169P, SER169Q, SER175P, SER175Q, SER177P, SER177Q, SER22P, SER22Q, SER251P, SER251Q, THR131P, THR131Q, THR216P, THR216Q, THR316P, THR316Q, TRP170P, TRP170Q, TYR207P, TYR207Q, TYR246P, TYR246Q, TYR249P, TYR249Q, TYR58P, TYR58Q, TYR8P, TYR8Q, VAL10P, VAL10Q, VAL13P, VAL13Q, VAL150P, VAL150Q, VAL176P, VAL176Q, VAL215P, VAL215Q, VAL23P, VAL23Q
• R-S: ALA236R, ARG229R, ARG333R, ASN314R, ASP322S, GLU302S, GLU313R, GLY317S, LYS373S
• S-T: ARG225S, ARG225T, ARG4S, ARG4T, ASN14S, ASN14T, ASP217S, ASP217T, GLU245S, GLU245T, PHE16S, PHE16T, PHE6S, PHE6T, TYR8S, TYR8T