3BBT

crystal structure of the erbb4 kinase in complex with lapatinib

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 112
  • Norm. En. per Res.: -1.8353
• Hub Node: B(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-D	-35.2843	4.4454	-174.719	-205.5579	112	10	2	8274	0	29	57

Interface residues

• B-D: ALA683B, ALA946B, ALA946D, ALA947B, ALA947D, ALA953B, ALA953D, ARG686B, ARG686D, ARG757B, ARG757D, ARG812B, ARG812D, ARG954B, ARG954D, ASN797B, ASN797D, ASN830B, ASN830D, ASP751B, ASP751D, GLN684D, GLN772B, GLN772D, GLN793B, GLN793D, GLN801B, GLN801D, GLU717B, GLU811B, GLU811D, GLU944B, GLU944D, GLY710B, GLY710D, HIS752B, HIS752D, HIS754B, HIS754D, HIS776B, HIS776D, HIS831B, HIS831D, ILE711B, ILE711D, ILE721B, ILE721D, LEU755B, LEU755D, LEU759B, LEU759D, LEU773B, LEU773D, LEU794B, LEU794D, LYS709B, LYS709D, LYS720B, LYS720D, LYS804B, LYS804D, LYS827B, LYS827D, LYS833B, LYS833D, LYS943B, LYS943D, MET750B, MET750D, MET774B, MET774D, MET807B, MET807D, PRO714B, PRO714D, PRO722B, PRO722D, PRO753B, PRO753D, PRO775B, PRO775D, PRO829B, PRO829D, PRO956D, SER749B, SER749D, SER828B, SER828D, SER950B, SER950D, THR718B, THR718D, TRP712B, TRP712D, TRP798D, TYR782B, TYR782D, TYR808B, TYR808D, VAL696B, VAL696D, VAL713B, VAL713D, VAL719B, VAL719D, VAL723B, VAL723D, VAL800B, VAL800D, VAL826D, VAL832B, VAL832D