3B5U

actin filament model from extended form of acromsomal bundle in the limulus sperm

• Total interactions analyzed: 91
• Total true interactions: 25
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 174
  • Norm. En. per Res.: -4.8295
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-7.7624	-2.6768	-142.203	-152.6421	86	12	3	6001	0	27	24
A-C	-32.4219	-22.3583	-75.5512	-130.3315	72	39	2	6362	0	21	24
B-C	-14.4383	-35.6915	-57.8139	-107.9437	63	29	2	3987	2	26	15
B-D	-16.0547	9.7189	-166.291	-172.6267	64	25	6	6658	2	14	17
C-D	-8.3178	0.0	-104.191	-112.5088	58	10	0	3778	0	15	11
C-E	-15.8224	-25.764	-149.945	-191.5314	72	15	3	6167	1	24	19
D-E	-61.0988	-66.8159	-315.136	-443.0507	122	45	1	12025	3	48	37
D-F	-29.0994	4.4876	517.866	493.2542	98	186	10	13785	2	27	24
E-F	-130.4238	-29.745	-680.161	-840.3298	174	99	6	24548	4	55	49
E-G	0.0	-29.2536	-63.7779	-93.0315	54	1	3	3200	2	16	13
F-G	-5.0339	-57.9923	-156.041	-219.0672	93	7	2	6690	5	33	23
F-H	0.0	-2.7547	159.33	156.5753	35	41	2	2177	0	6	13
G-H	-4.5082	0.0	-30.6089	-35.1171	35	5	0	1835	0	8	5
G-I	-10.517	-23.4658	-65.4452	-99.428	52	9	1	3626	0	18	21
H-I	-12.2791	-39.3338	-53.4983	-105.1112	49	2	1	2240	3	14	7
H-J	-12.9154	-9.7847	-76.5731	-99.2732	54	2	1	3423	0	22	14
I-J	-43.7309	-56.388	-214.086	-314.2049	116	28	3	9635	5	45	37
I-K	-11.0739	-2.5876	-91.2144	-104.8759	67	6	2	4578	0	21	23
J-K	-9.2234	-11.9439	-10.7372	-31.9045	92	32	1	7460	1	31	22
J-L	-20.9334	26.7363	-323.914	-318.1111	94	20	6	12308	0	32	36
K-L	-40.8162	-38.5787	-263.603	-342.9979	124	41	2	12457	3	56	40
K-M	-54.0775	-15.2741	-163.148	-232.4996	60	17	1	6021	2	18	13
L-M	-48.8857	-67.6227	-225.747	-342.2554	116	24	1	9471	4	41	36
L-N	-33.2426	-31.6981	-138.977	-203.9177	51	11	2	5266	2	25	15
M-N	-87.2237	-63.507	-350.97	-501.7008	132	26	3	13045	5	46	37

Interface residues

• A-B: ALA114B, ALA174B, ALA204A, ALA58A, ARG177B, ARG196A, ARG206A, ARG256A, ARG290B, ARG37A, ARG39A, ARG62A, ASN111B, ASN115B, ASN280B, ASP179A, ASP179B, ASP184A, ASP286B, ASP288B, CYS285B, GLN59A, GLU195A, GLU207A, GLU270A, GLU270B, GLU57A, GLU72B, GLY197A, GLY268A, GLY268B, GLY36A, GLY63A, HIS173B, HIS40A, HIS73B, ILE175B, ILE192A, ILE267A, ILE267B, ILE287B, ILE289B, ILE34A, ILE64A, ILE75B, LEU110B, LEU171B, LEU180A, LEU65A, LEU67A, LYS113B, LYS191A, LYS191B, LYS284B, LYS61A, LYS68A, MET176B, MET190A, MET269A, MET269B, MET283B, PHE200A, PHE266A, PHE266B, PRO112B, PRO164B, PRO172B, PRO264B, PRO38A, SER199A, SER265A, SER265B, SER281B, SER60A, THR194A, THR202A, THR203A, THR66A, THR77B, TYR166B, TYR188B, TYR198A, TYR53A, TYR69A, VAL201A, VAL35A
• A-C: ALA170C, ALA204A, ALA319C, ALA321C, ALA58A, ARG147C, ARG206A, ARG290C, ARG372C, ARG39A, ARG62A, ASP244A, ASP286C, ASP288C, ASP56A, CYS285C, CYS374C, GLN246A, GLN41A, GLN49A, GLN59A, GLU167C, GLU205A, GLU207A, GLU241A, GLU57A, GLY168C, GLY245A, GLY42A, GLY46A, GLY48A, GLY63A, HIS173C, HIS40A, ILE165C, ILE208A, ILE287C, ILE289C, ILE64A, LEU171C, LEU242A, LEU320C, LEU65A, LYS284C, LYS291C, LYS61A, MET283C, MET325C, MET355C, MET44A, MET47A, PHE375C, PRO172C, PRO243A, PRO322C, SER323C, SER60A, THR148C, THR149C, THR202A, THR203A, THR318C, THR324C, TYR143C, TYR166C, TYR169C, TYR279C, TYR294C, TYR53A, VAL201A, VAL43A, VAL45A
• B-C: ALA114C, ALA204B, ALA58B, ARG177C, ARG196B, ARG206B, ARG256B, ARG290C, ARG37B, ARG39B, ARG62B, ASP179C, ASP286C, CYS285C, GLN263C, GLN41B, GLN59B, GLU195B, GLU270C, GLU72C, GLY197B, GLY268B, GLY268C, GLY42B, GLY63B, HIS173C, HIS40B, HIS73C, ILE267B, ILE267C, ILE287C, ILE64B, ILE75C, LEU110C, LEU65B, LEU67B, LYS113C, LYS191B, LYS284C, LYS61B, MET269B, MET269C, MET283C, MET44B, PHE266B, PHE266C, PRO112C, PRO172C, PRO264C, PRO38B, SER199B, SER265C, SER271C, SER60B, THR194B, THR202B, THR203B, THR260C, THR66B, THR77C, TYR188C, TYR198B, VAL201B
• B-D: ALA170D, ALA174D, ALA204B, ALA319D, ALA321D, ALA58B, ARG290D, ARG62B, ASP244B, ASP286D, ASP288D, ASP56B, CYS285D, GLN41B, GLN49B, GLN59B, GLU167D, GLU57B, GLY150D, GLY168D, GLY42B, GLY46B, GLY48B, GLY55B, HIS173D, HIS371D, HIS40B, ILE151D, ILE165D, ILE175D, ILE287D, ILE289D, ILE64B, LEU171D, LEU242B, LEU293D, LEU320D, LEU65B, LYS284D, LYS50B, LYS61B, MET283D, MET44B, MET47B, PHE375D, PRO164D, PRO172D, PRO243B, PRO322D, PRO38B, SER323D, SER60B, THR148D, THR149D, THR202B, THR203B, TYR166D, TYR169D, TYR279D, TYR53B, VAL139D, VAL163D, VAL43B, VAL45B
• C-D: ALA174D, ALA204C, ALA58C, ARG177D, ARG206C, ARG210C, ARG256D, ARG290D, ARG39C, ARG62C, ASN280D, ASP179D, ASP187C, ASP286D, CYS285D, GLN59C, GLU195D, GLU205C, GLU207C, GLU270D, GLY268C, GLY268D, GLY63C, HIS173D, HIS40C, HIS73D, ILE267C, ILE267D, ILE282D, ILE287D, ILE64C, LEU171D, LEU180D, LEU65C, LEU67C, LYS284D, LYS61C, MET190C, MET227D, MET269C, MET269D, MET283D, PHE200C, PHE266C, PHE266D, PRO172D, SER199C, SER265D, SER271D, SER281D, SER60C, THR194C, THR202C, THR203C, THR66C, TYR188D, TYR69C, VAL201C
• C-E: ALA204C, ALA321E, ARG206C, ARG290E, ARG372E, ARG39C, ARG62C, ASP244C, ASP286E, ASP288E, ASP292E, CYS285E, CYS374E, GLN246C, GLN354E, GLN41C, GLN49C, GLU167E, GLU205C, GLU207C, GLU241C, GLY168E, GLY245C, GLY42C, GLY46C, GLY63C, HIS173E, HIS40C, ILE208C, ILE248C, ILE282E, ILE287E, ILE289E, ILE64C, LEU242C, LEU346E, LEU349E, LYS284E, LYS291E, LYS326E, LYS373E, LYS61C, MET283E, MET325E, MET355E, MET44C, MET47C, PHE200C, PHE352E, PHE375E, PRO243C, PRO322E, SER199C, SER281E, SER323E, SER60C, THR202C, THR203C, THR324E, THR351E, TYR133E, TYR143E, TYR166E, TYR169E, TYR240C, TYR279E, TYR294E, VAL201C, VAL209C, VAL247C, VAL43C, VAL45C
• D-E: ALA108E, ALA114E, ALA170E, ALA174E, ALA204D, ALA272E, ALA58D, ARG116E, ARG177E, ARG196D, ARG206D, ARG256D, ARG256E, ARG312E, ARG39D, ARG62D, ASN111E, ASN115E, ASN162E, ASN252D, ASN78E, ASP179E, ASP187D, ASP244D, ASP286E, ASP288E, ASP56D, CYS285E, GLN246D, GLN263E, GLN41D, GLN59D, GLU107E, GLU117E, GLU195D, GLU205D, GLU207D, GLU253D, GLU259E, GLU270E, GLU276E, GLU57D, GLU72E, GLY158E, GLY197D, GLY245D, GLY268E, GLY273E, GLY36D, GLY42D, GLY63D, GLY74E, HIS161E, HIS173E, HIS275E, HIS371E, HIS40D, HIS73E, ILE175E, ILE192D, ILE250D, ILE267D, ILE267E, ILE274E, ILE34D, ILE64D, ILE75E, ILE76E, LEU110E, LEU171E, LEU178E, LEU180E, LEU193D, LEU242D, LEU261E, LEU320E, LEU65D, LEU67D, LYS113E, LYS191D, LYS284E, LYS61D, MET176E, MET190D, MET227E, MET269D, MET269E, MET44D, PHE200D, PHE223E, PHE262E, PHE266D, PHE266E, PHE375E, PRO109E, PRO112E, PRO172E, PRO264E, PRO38D, SER199D, SER265E, SER271E, SER60D, THR160E, THR194D, THR202D, THR203D, THR249D, THR260E, THR277E, THR66D, THR77E, TRP79E, TYR166E, TYR169E, TYR188D, TYR198D, TYR53D, TYR69D, VAL159E, VAL201D, VAL43D
• D-F: ALA138F, ALA170F, ALA174F, ALA204D, ALA295F, ALA319F, ALA321F, ALA58D, ARG147F, ARG290F, ARG37D, ARG39D, ARG62D, ASN162F, ASN296F, ASN297F, ASP244D, ASP286F, ASP288F, ASP292F, ASP51D, ASP56D, CYS285F, GLN41D, GLN49D, GLN59D, GLU167F, GLU205D, GLU207D, GLU57D, GLY150F, GLY168F, GLY36D, GLY42D, GLY46D, GLY48D, GLY55D, GLY63D, HIS173F, HIS40D, HIS88D, ILE151F, ILE165F, ILE175F, ILE208D, ILE282F, ILE287F, ILE289F, ILE330F, ILE34D, ILE64D, LEU142F, LEU153F, LEU171F, LEU242D, LEU293F, LEU65D, LEU67D, LYS284F, LYS291F, LYS326F, LYS50D, LYS61D, MET283F, MET325F, MET44D, MET47D, PHE375F, PRO164F, PRO172F, PRO243D, PRO322F, PRO38D, SER141F, SER281F, SER323F, SER52D, SER60D, THR148F, THR149F, THR202D, THR203D, THR324F, THR66D, TYR143F, TYR166F, TYR169F, TYR279F, TYR294F, TYR53D, VAL139F, VAL152F, VAL163F, VAL298F, VAL35D, VAL43D, VAL45D, VAL54D
• E-F: ALA108F, ALA174F, ALA181F, ALA204E, ALA220F, ALA228F, ALA230F, ALA231E, ALA231F, ALA272F, ALA321F, ALA58E, ARG177F, ARG183E, ARG183F, ARG196E, ARG206E, ARG210E, ARG256E, ARG256F, ARG290F, ARG37E, ARG39E, ARG62E, ASN162F, ASN225F, ASN252F, ASN280F, ASP157E, ASP179E, ASP179F, ASP184E, ASP184F, ASP187E, ASP187F, ASP211E, ASP222F, ASP286F, ASP288F, ASP292F, ASP56E, CYS257F, CYS285F, GLN246E, GLN263E, GLN263F, GLN41E, GLN59E, GLU195E, GLU205E, GLU207E, GLU214E, GLU224F, GLU226F, GLU253E, GLU259F, GLU270E, GLU270F, GLU276F, GLU57E, GLU72E, GLY158E, GLY158F, GLY15E, GLY182E, GLY197E, GLY268E, GLY268F, GLY273F, GLY55E, GLY63E, GLY74F, HIS161F, HIS173F, HIS275F, HIS40E, HIS73E, HIS73F, ILE151F, ILE175F, ILE192E, ILE192F, ILE208E, ILE212E, ILE267E, ILE267F, ILE274F, ILE282F, ILE287F, ILE289F, ILE34E, ILE64E, ILE75F, LEU110F, LEU153F, LEU16E, LEU171F, LEU178F, LEU180E, LEU180F, LEU185E, LEU185F, LEU189E, LEU193E, LEU261F, LEU293F, LEU320F, LEU65E, LEU67E, LYS113F, LYS191E, LYS191F, LYS213E, LYS215E, LYS284F, LYS291F, LYS61E, LYS68E, MET176F, MET190E, MET227E, MET227F, MET269E, MET269F, MET283F, MET325F, PHE200E, PHE223E, PHE223F, PHE255F, PHE262F, PHE266E, PHE266F, PRO109F, PRO112F, PRO164F, PRO172F, PRO264E, PRO264F, PRO322F, PRO32E, PRO38E, SER14E, SER199E, SER232E, SER265E, SER265F, SER271E, SER271F, SER281F, SER60E, THR160F, THR186E, THR194E, THR202E, THR203E, THR229F, THR260E, THR260F, THR277F, THR278F, THR324F, THR66E, TYR188E, TYR188F, TYR198E, TYR240E, TYR279F, TYR294F, TYR69E, VAL159F, VAL163F, VAL201E, VAL209E
• E-G: ALA170G, ALA204E, ALA321G, ARG206E, ARG290G, ARG372G, ASP244E, ASP286G, ASP288G, CYS285G, CYS374G, GLN246E, GLN41E, GLU167G, GLU205E, GLU241E, GLY168G, GLY245E, GLY42E, GLY46E, HIS173G, ILE208E, ILE282G, ILE287G, ILE289G, ILE64E, LEU242E, LEU320G, LYS284G, LYS291G, LYS373G, MET283G, MET325G, MET355G, MET44E, PHE200E, PHE375G, PRO243E, PRO322G, SER323G, SER60E, THR148G, THR202E, THR203E, THR324G, THR351G, TYR166G, TYR169G, TYR279G, TYR294G, VAL201E, VAL247E, VAL43E, VAL45E
• F-G: ALA108G, ALA114G, ALA170G, ALA174G, ALA231F, ALA272G, ARG177G, ARG196F, ARG206F, ARG256F, ARG372G, ARG39F, ARG62F, ASN111G, ASN280G, ASP179G, ASP184F, ASP187F, ASP286G, ASP288G, CYS285G, GLN246F, GLN263G, GLU107G, GLU195F, GLU205F, GLU237F, GLU253F, GLU270G, GLY197F, GLY251F, GLY268G, GLY42F, GLY63F, HIS161G, HIS173G, HIS371G, HIS40F, HIS73G, ILE136G, ILE175G, ILE192F, ILE248F, ILE250F, ILE267F, ILE267G, ILE287G, ILE289G, ILE64F, ILE75G, LEU110G, LEU171G, LEU178G, LEU193F, LEU65F, LYS113G, LYS191F, LYS284G, LYS61F, MET176G, MET190F, MET269G, MET283G, MET44F, PHE200F, PHE266F, PHE266G, PHE375G, PRO109G, PRO112G, PRO164G, PRO172G, PRO264F, SER199F, SER232F, SER265G, SER271G, SER281G, SER60F, THR160G, THR186F, THR194F, THR202F, THR203F, THR249F, THR277G, TYR166G, TYR169G, TYR188F, TYR198F, VAL159G, VAL201F, VAL247F
• F-H: ALA204F, ARG372H, ASP286H, ASP288H, ASP56F, CYS374H, GLN41F, GLN49F, GLU167H, GLU57F, GLY168H, GLY42F, GLY46F, GLY48F, HIS173H, HIS40F, ILE165H, ILE287H, ILE289H, ILE64F, LEU171H, LYS373H, LYS61F, MET355H, MET44F, MET47F, PHE375H, SER60F, THR148H, THR149H, TYR166H, TYR169H, TYR53F, VAL43F, VAL45F
• G-H: ALA114H, ALA170H, ALA174H, ARG256G, ARG39G, ARG62G, ASP286H, CYS285H, GLU195G, GLU270H, GLY268G, GLY268H, GLY63G, HIS173H, HIS40G, ILE175H, ILE267G, ILE267H, ILE64G, LEU110H, LEU171H, LEU65G, LYS113H, LYS191G, LYS284H, MET269G, MET269H, PHE266G, PHE266H, PHE375H, PRO112H, PRO172H, PRO38G, THR66G, TYR169H
• G-I: ALA204G, ALA321I, ARG206G, ARG290I, ARG372I, ARG39G, ARG62G, ASP244G, ASP286I, ASP288I, CYS285I, CYS374I, GLN41G, GLN59G, GLU167I, GLU205G, GLU207G, GLY168I, GLY245G, GLY42G, GLY46G, GLY63G, HIS173I, HIS40G, ILE287I, ILE289I, ILE64G, LEU171I, LEU242G, LYS284I, LYS61G, MET283I, MET325I, MET355I, MET44G, PHE375I, PRO172I, PRO243G, PRO322I, SER323I, SER60G, THR148I, THR149I, THR202G, THR203G, THR324I, TYR166I, TYR169I, TYR279I, VAL201G, VAL43G, VAL45G
• H-I: ALA114I, ARG177I, ARG206H, ARG256H, ARG39H, ARG62H, ASP179I, GLN59H, GLU195H, GLU270I, GLU72I, GLY197H, GLY268I, GLY63H, HIS173I, HIS40H, HIS73I, ILE267H, ILE267I, ILE64H, ILE75I, LEU110I, LEU65H, LEU67H, LYS113I, LYS191H, LYS284I, LYS61H, MET269H, MET269I, MET44H, PHE200H, PHE266H, PHE266I, PHE375I, PRO112I, PRO172I, PRO264I, SER199H, SER265I, SER271I, SER60H, THR194H, THR202H, THR203H, THR66H, THR77I, TYR198H, VAL201H
• H-J: ALA204H, ALA321J, ARG147J, ARG206H, ARG290J, ARG62H, ASP244H, ASP286J, ASP288J, CYS285J, GLN246H, GLU167J, GLU205H, GLU207H, GLU241H, GLY146J, GLY168J, GLY245H, GLY46H, HIS40H, ILE208H, ILE287J, ILE289J, ILE64H, LEU242H, LEU349J, LYS284J, LYS291J, LYS61H, MET283J, MET325J, MET355J, MET44H, PHE200H, PHE375J, PRO243H, PRO322J, SER199H, SER323J, SER60H, THR148J, THR149J, THR202H, THR203H, THR324J, THR351J, TYR143J, TYR166J, TYR169J, TYR279J, TYR294J, VAL201H, VAL43H, VAL45H
• I-J: ALA108J, ALA114J, ALA170J, ALA174J, ALA204I, ALA228I, ALA230I, ALA231I, ALA272J, ALA365J, ARG116J, ARG177J, ARG196I, ARG206I, ARG254I, ARG256I, ARG372J, ARG39I, ARG62I, ASN111J, ASN115J, ASN252I, ASP179J, ASP187I, ASP286J, ASP288J, CYS285J, GLN246I, GLN263J, GLN59I, GLU107J, GLU117J, GLU167J, GLU195I, GLU205I, GLU207I, GLU224I, GLU237I, GLU253I, GLU270J, GLU72J, GLY158J, GLY197I, GLY251I, GLY268I, GLY268J, GLY366J, GLY42I, GLY63I, GLY74J, HIS161J, HIS173J, HIS371J, HIS40I, HIS73J, ILE136J, ILE175J, ILE192I, ILE250I, ILE267I, ILE267J, ILE287J, ILE289J, ILE369J, ILE64I, ILE75J, ILE76J, LEU110J, LEU171J, LEU178J, LEU180J, LEU193I, LEU65I, LYS113J, LYS191I, LYS284J, LYS61I, MET119J, MET176J, MET190I, MET227I, MET269I, MET269J, MET44I, PHE200I, PHE223I, PHE255I, PHE266I, PHE266J, PHE375J, PRO109J, PRO112J, PRO172J, PRO264J, PRO367J, SER199I, SER232I, SER265I, SER265J, SER271J, SER368J, SER60I, THR160J, THR194I, THR202I, THR203I, THR249I, THR66I, THR77J, TRP79J, TYR166J, TYR169J, TYR188I, TYR198I, VAL159J, VAL201I
• I-K: ALA170K, ALA204I, ALA321K, ARG290K, ARG372K, ARG62I, ASP244I, ASP286K, ASP288K, ASP56I, CYS285K, CYS374K, GLN246I, GLN41I, GLN49I, GLN59I, GLU167K, GLU205I, GLU207I, GLU241I, GLU57I, GLY168K, GLY245I, GLY42I, GLY46I, GLY63I, HIS173K, HIS40I, ILE165K, ILE208I, ILE282K, ILE287K, ILE289K, ILE64I, LEU171K, LEU242I, LEU320K, LEU346K, LYS284K, LYS291K, LYS373K, LYS61I, MET283K, MET325K, MET355K, MET44I, MET47I, PHE375K, PRO243I, PRO322K, SER323K, SER60I, THR148K, THR149K, THR202I, THR203I, THR324K, THR351K, TYR133K, TYR143K, TYR166K, TYR169K, TYR279K, TYR294K, VAL139K, VAL43I, VAL45I
• J-K: ALA108K, ALA170K, ALA174K, ALA204J, ALA272K, ALA58J, ARG177K, ARG196J, ARG206J, ARG256J, ARG290K, ARG39J, ARG62J, ASN111K, ASN280K, ASP179K, ASP184J, ASP184K, ASP286K, CYS285K, GLN263K, GLN59J, GLU195J, GLU205J, GLU207J, GLU270J, GLU270K, GLU57J, GLU72K, GLY197J, GLY268J, GLY268K, GLY63J, HIS173K, HIS73K, ILE165K, ILE175K, ILE192J, ILE267J, ILE267K, ILE282K, ILE287K, ILE289K, ILE64J, ILE75K, ILE76K, LEU110K, LEU171K, LEU178K, LEU180J, LEU180K, LEU193J, LEU293K, LEU65J, LEU67J, LYS113K, LYS191J, LYS284K, LYS61J, MET176K, MET190J, MET227J, MET269J, MET269K, MET283K, PHE200J, PHE266J, PHE266K, PHE375K, PRO109K, PRO112K, PRO164K, PRO172K, PRO264K, SER199J, SER265J, SER265K, SER271K, SER281K, SER60J, THR194J, THR202J, THR203J, THR66J, THR77K, TYR166K, TYR169K, TYR188J, TYR198J, VAL159K, VAL163K, VAL201J
• J-L: ALA174L, ALA204J, ALA295L, ALA321L, ARG196J, ARG206J, ARG210J, ARG290L, ARG372L, ARG39J, ARG62J, ASN296L, ASP211J, ASP244J, ASP286L, ASP288L, ASP292L, CYS285L, CYS374L, GLN246J, GLN353L, GLN354L, GLN41J, GLN49J, GLU167L, GLU205J, GLU207J, GLU241J, GLU361L, GLY197J, GLY245J, GLY42J, GLY46J, GLY63J, HIS173L, HIS40J, ILE208J, ILE212J, ILE248J, ILE250J, ILE282L, ILE287L, ILE289L, ILE327L, ILE369L, ILE64J, LEU171L, LEU189J, LEU193J, LEU216J, LEU242J, LEU293L, LEU349L, LYS213J, LYS284L, LYS291L, LYS326L, LYS373L, MET190J, MET283L, MET325L, MET355L, MET44J, MET47J, PHE200J, PHE352L, PHE375L, PRO164L, PRO172L, PRO243J, PRO322L, PRO38J, SER199J, SER239J, SER281L, SER323L, SER350L, THR194J, THR202J, THR203J, THR249J, THR324L, THR351L, TYR166L, TYR169L, TYR198J, TYR240J, TYR279L, TYR294L, VAL201J, VAL209J, VAL247J, VAL43J, VAL45J
• K-L: ALA108L, ALA114L, ALA170L, ALA174L, ALA204K, ALA231K, ALA272L, ALA58K, ARG116L, ARG177L, ARG183L, ARG196K, ARG206K, ARG256K, ARG37K, ARG39K, ARG62K, ASN111L, ASN115L, ASN252K, ASN78L, ASP179L, ASP184K, ASP184L, ASP187K, ASP286L, CYS374L, GLN246K, GLN263L, GLN59K, GLU107L, GLU117L, GLU167L, GLU195K, GLU205K, GLU207K, GLU253K, GLU259K, GLU270K, GLU270L, GLU276L, GLU57K, GLU72L, GLY158L, GLY197K, GLY268K, GLY268L, GLY273L, GLY36K, GLY63K, GLY74L, HIS161L, HIS173L, HIS275L, HIS371L, HIS40K, HIS73K, HIS73L, ILE175L, ILE192K, ILE267K, ILE267L, ILE64K, ILE71L, ILE75L, ILE76L, LEU110L, LEU171L, LEU178L, LEU180K, LEU180L, LEU189K, LEU193K, LEU65K, LEU67K, LYS113L, LYS118L, LYS191K, LYS284L, LYS61K, MET119L, MET176L, MET190K, MET227K, MET269K, MET269L, MET44K, PHE200K, PHE223K, PHE223L, PHE255K, PHE262L, PHE266K, PHE266L, PHE375L, PRO109L, PRO112L, PRO164L, PRO172L, PRO264L, PRO367L, PRO38K, PRO70L, SER199K, SER265K, SER265L, SER271L, SER368L, SER60K, THR194K, THR202K, THR203K, THR260K, THR260L, THR66K, THR77L, TRP79L, TYR166L, TYR169L, TYR188K, TYR198K, TYR69L, VAL159L, VAL201K
• K-M: ALA204K, ALA321M, ARG206K, ARG290M, ARG372M, ASP244K, ASP286M, ASP288M, ASP292M, CYS285M, GLN246K, GLN354M, GLN41K, GLN49K, GLU205K, GLU207K, GLU241K, GLY245K, GLY42K, GLY46K, HIS173M, ILE208K, ILE212K, ILE248K, ILE282M, ILE287M, ILE289M, ILE327M, LEU171M, LEU193K, LEU242K, LEU293M, LYS284M, LYS291M, LYS326M, LYS373M, MET283M, MET325M, MET355M, PHE200K, PHE375M, PRO243K, PRO322M, SER199K, SER323M, THR202K, THR203K, THR324M, THR351M, TYR166M, TYR169M, TYR198K, TYR240K, TYR279M, TYR294M, VAL201K, VAL209K, VAL247K, VAL43K, VAL45K
• L-M: ALA114M, ALA204L, ALA272M, ALA58L, ARG116M, ARG177M, ARG183L, ARG196L, ARG206L, ARG256L, ARG312M, ARG37L, ARG39L, ARG62L, ASN111M, ASN115M, ASN280M, ASN78M, ASP179M, ASP184L, ASP187L, ASP286M, CYS285M, GLN246L, GLN263M, GLN41L, GLN59L, GLU117M, GLU195L, GLU205L, GLU253L, GLU259M, GLU270M, GLU276M, GLU57L, GLU72L, GLU72M, GLY158M, GLY197L, GLY268M, GLY273M, GLY42L, GLY46L, GLY63L, GLY74M, HIS173M, HIS275M, HIS371M, HIS40L, HIS73L, HIS73M, ILE192L, ILE267L, ILE267M, ILE274M, ILE289M, ILE64L, ILE71M, ILE75M, ILE76M, LEU110M, LEU171M, LEU178M, LEU180M, LEU193L, LEU261M, LEU320M, LEU65L, LEU67L, LYS113M, LYS118M, LYS191L, LYS284M, LYS61L, LYS68L, MET176M, MET190L, MET269L, MET269M, MET283M, MET44L, MET47L, PHE200L, PHE223M, PHE262M, PHE266L, PHE266M, PHE375M, PRO112M, PRO172M, PRO264M, PRO38L, SER199L, SER265M, SER271M, SER368M, SER60L, THR194L, THR202L, THR203L, THR260M, THR277M, THR66L, THR77L, THR77M, TRP79M, TYR169M, TYR188L, TYR198L, TYR279M, TYR53L, TYR69L, VAL159M, VAL201L, VAL43L, VAL45L
• L-N: ALA204L, ALA321N, ARG206L, ARG290N, ARG62L, ASP244L, ASP286N, ASP288N, ASP292N, CYS285N, GLN246L, GLU205L, GLU207L, GLU241L, GLY245L, HIS173N, ILE208L, ILE248L, ILE282N, ILE287N, ILE289N, ILE327N, LEU242L, LEU293N, LEU320N, LYS284N, LYS291N, LYS326N, LYS61L, MET283N, MET325N, MET44L, PHE200L, PHE375N, PRO243L, PRO322N, SER199L, SER239L, SER323N, SER60L, THR202L, THR203L, THR324N, TYR166N, TYR169N, TYR240L, TYR279N, TYR294N, VAL201L, VAL247L, VAL45L
• M-N: ALA114N, ALA170N, ALA181N, ALA272N, ALA58M, ARG116N, ARG177N, ARG183M, ARG196M, ARG206M, ARG256M, ARG256N, ARG37M, ARG39M, ARG62M, ASN111N, ASN115N, ASN280N, ASN78N, ASP179N, ASP184M, ASP184N, ASP187M, ASP286N, ASP288N, ASP51M, ASP81M, CYS257N, CYS285N, GLN263N, GLN41M, GLN49M, GLN59M, GLU117N, GLU195M, GLU253M, GLU259N, GLU270M, GLU270N, GLU276N, GLU57M, GLU72M, GLU72N, GLY197M, GLY268M, GLY268N, GLY273N, GLY36M, GLY42M, GLY48M, GLY55M, GLY63M, HIS173N, HIS275N, HIS40M, HIS73M, HIS73N, ILE192M, ILE192N, ILE267M, ILE267N, ILE274N, ILE287N, ILE289N, ILE34M, ILE64M, ILE75N, ILE76N, LEU110N, LEU171N, LEU178N, LEU180M, LEU180N, LEU185N, LEU193M, LEU261N, LEU320N, LEU65M, LEU67M, LYS113N, LYS118N, LYS191M, LYS191N, LYS284N, LYS50M, LYS61M, LYS68M, MET176N, MET190M, MET227N, MET269M, MET269N, MET283N, MET44M, MET47M, PHE200M, PHE223N, PHE262N, PHE266M, PHE266N, PHE375N, PRO112N, PRO172N, PRO264N, PRO38M, SER199M, SER265N, SER271N, SER52M, SER60M, THR194M, THR202M, THR203M, THR260N, THR277N, THR66M, THR77M, THR77N, TRP79N, TYR166N, TYR169N, TYR188M, TYR188N, TYR198M, TYR279N, TYR53M, TYR69M, VAL201M, VAL35M, VAL43M, VAL45M, VAL54M