3B2V

crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the fab fragment of imc-11f8

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: L-A
  • Int. Res.: 42
  • Norm. En. per Res.: -2.9743
• Hub Node: L(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-H	-11.5667	-8.1029	-251.244	-270.9136	171	24	12	13101	0	18	17
L-A	-35.7827	0.0	-89.137	-124.9197	42	12	2	3172	0	4	2
H-A	-9.9736	-23.4627	-109.75	-143.1863	68	7	3	5031	1	6	1

Interface residues

• L-H: ALA130L, ALA133H, ALA144H, ALA145H, ALA176H, ALA213L, ALA34L, ALA43L, ALA55L, ALA98H, ARG211L, ARG40H, ARG45L, ARG99H, ASN137L, ASN138L, ASN210L, ASN53L, ASN62H, ASP109H, ASP122L, ASP152H, ASP167L, ASP170L, ASP50L, ASP60H, CYS134L, CYS148H, CYS88L, CYS97H, GLN113H, GLN124L, GLN160L, GLN179H, GLN37L, GLN38L, GLN41H, GLN42L, GLN6L, GLN90L, GLU123L, GLU161L, GLU165L, GLU1L, GLU48H, GLY100L, GLY101L, GLY104H, GLY106H, GLY112H, GLY114H, GLY142H, GLY147H, GLY170H, GLY212L, GLY41L, GLY44H, GLY46H, GLY51H, GLY92L, GLY99L, HIS172H, HIS89L, ILE117L, ILE2L, ILE39H, ILE48L, ILE50H, LEU125L, LEU132H, LEU135L, LEU136L, LEU146H, LEU149H, LEU175L, LEU178H, LEU179L, LEU186H, LEU33L, LEU46L, LEU47H, LEU47L, LEU65H, LEU96L, LYS151H, LYS169L, LYS207L, LYS217H, LYS222H, LYS39L, LYS45H, PHE108H, PHE116L, PHE118L, PHE130H, PHE174H, PHE209L, PHE98L, PRO119L, PRO120L, PRO131H, PRO134H, PRO175H, PRO40L, PRO44L, PRO63H, PRO95L, SER101H, SER114L, SER121L, SER127L, SER128H, SER131L, SER135H, SER136H, SER162L, SER168L, SER174L, SER176L, SER177L, SER180H, SER185H, SER187H, SER188H, SER194H, SER208L, SER37H, SER64H, SER93L, THR107H, THR129L, THR143H, THR164L, THR172L, THR173H, THR178L, THR180L, THR191H, THR56L, THR94L, THR97L, TRP111H, TRP35L, TRP38H, TRP49H, TYR110H, TYR173L, TYR32L, TYR35H, TYR36L, TYR49L, TYR52H, TYR61H, TYR86L, TYR87L, TYR91L, TYR96H, VAL100H, VAL105H, VAL115L, VAL129H, VAL132L, VAL133L, VAL163L, VAL171H, VAL177H, VAL189H, VAL190H, VAL192H, VAL85L, VAL94H
• L-A: ARG470A, ASN442A, ASN444A, ASN449A, ASN469A, ASN473A, ASP50L, CYS475A, GLN27L, GLN90L, GLU1L, GLU472A, GLY441A, GLY471A, GLY92L, ILE2L, ILE438A, ILE439A, ILE466A, ILE467A, LEU33L, LEU445A, LEU96L, LYS443A, LYS463A, LYS465A, LYS476A, PRO95L, SER28L, SER30L, SER31L, SER440A, SER468A, SER474A, SER93L, THR464A, THR94L, TYR32L, TYR49L, TYR91L, VAL29L, VAL437A
• H-A: ALA351A, ALA385A, ALA415A, ARG353A, ASN420A, ASN442A, ASN444A, ASN469A, ASP33H, ASP60H, GLN384A, GLN408A, GLN411A, GLU388A, GLY104H, GLY106H, GLY32H, GLY410A, GLY441A, GLY57H, HIS346A, HIS409A, ILE102H, ILE347A, ILE383A, ILE438A, ILE439A, ILE467A, ILE53H, LEU325A, LEU348A, LEU381A, LEU382A, LEU419A, LYS407A, LYS443A, LYS465A, PHE103H, PHE380A, PHE412A, PRO349A, PRO63H, SER101H, SER30H, SER31H, SER326A, SER418A, SER440A, SER468A, SER474A, SER56H, SER58H, THR107H, THR59H, THR75H, TRP386A, TRP49H, TYR34H, TYR35H, TYR52H, TYR54H, TYR55H, TYR61H, VAL100H, VAL105H, VAL350A, VAL416A, VAL417A