3B07

crystal structure of octameric pore form of gamma-hemolysin from staphylococcus aureus

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 196
  • Norm. En. per Res.: -4.6197
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	0.0	0.0	-0.6288	-0.6288	8	0	0	116	0	0	0
A-G	0.0	0.0	-0.8185	-0.8185	9	0	0	143	0	0	0
A-B	-272.145	-74.1362	-525.266	-871.5471	194	32	7	19809	5	45	42
A-H	-318.6024	-22.1806	-671.587	-1012.3699	229	39	9	24572	1	40	45
C-E	0.0	0.0	-0.7578	-0.7578	8	0	0	129	0	0	0
C-B	-319.2769	-27.0391	-653.598	-999.9139	227	49	9	24158	1	41	45
C-D	-285.4985	-63.3007	-556.669	-905.4682	196	30	7	20477	4	45	42
E-G	0.0	0.0	-0.6933	-0.6933	8	0	0	114	0	0	0
E-D	-318.5749	-25.6887	-668.83	-1013.0937	229	50	9	24648	2	40	46
E-F	-276.1982	-72.2225	-535.065	-883.4857	199	42	7	20283	6	45	42
G-F	-310.9755	-16.5535	-674.838	-1002.367	229	48	9	24831	0	41	46
G-H	-259.8021	-61.0117	-533.11	-853.9238	198	27	7	20156	4	45	42
B-D	0.0	0.0	-22.5721	-22.5721	14	2	0	849	0	0	0
B-H	0.0	0.0	-28.2171	-28.2171	15	3	0	972	0	0	0
D-F	-6.2474	0.0	-24.4169	-30.6643	14	2	0	916	0	0	0
F-H	0.0	0.0	-24.7519	-24.7519	14	1	0	888	0	0	0

Interface residues

• A-C: ASN113C, ASN175A, GLY176A, GLY178A, LEU115C, MET173A, PHE139C, TRP177A
• A-G: ASN113A, ASN175G, GLU141A, GLY176G, GLY178G, LEU115A, MET173G, PHE139A, TRP177G
• A-B: ALA103B, ALA11B, ALA120B, ALA138A, ALA160B, ALA169A, ALA172B, ALA210A, ALA24A, ALA26A, ALA45B, ARG151A, ARG219A, ASN112B, ASN113A, ASN116B, ASN130B, ASN134A, ASN136A, ASN144A, ASN150B, ASN161B, ASN175A, ASN221A, ASN223A, ASN285A, ASN40A, ASN42B, ASN59A, ASN61A, ASN93B, ASN98B, ASP101B, ASP104B, ASP122A, ASP174B, ASP252B, ASP27A, ASP282A, ASP29A, ASP38B, ASP44B, ASP90B, GLN107B, GLN110A, GLN112A, GLN118B, GLN147A, GLN149B, GLN211A, GLN213A, GLN35A, GLU141A, GLU145B, GLU147B, GLU148A, GLU168A, GLU216B, GLU225A, GLY110B, GLY114B, GLY115B, GLY116A, GLY120A, GLY121A, GLY124B, GLY125B, GLY131A, GLY132A, GLY135A, GLY153B, GLY176A, GLY178A, GLY58A, HIS170A, HIS212A, HIS215B, HIS251B, HIS286A, ILE100B, ILE113B, ILE123A, ILE135B, ILE143A, ILE172A, ILE33A, ILE36A, ILE60A, ILE92B, LEU109B, LEU115A, LEU129A, LEU133A, LEU19A, LEU213B, LEU216A, LEU217A, LEU290A, LEU37A, LEU91B, LEU95B, LYS108B, LYS133B, LYS146A, LYS152B, LYS155B, LYS159B, LYS171A, LYS21A, LYS287A, LYS289A, LYS32A, LYS39B, LYS40B, LYS43B, LYS55A, LYS66A, LYS97B, LYS99B, MET173A, MET214A, PHE109A, PHE117B, PHE119A, PHE129B, PHE139A, PHE222A, PHE226A, PHE39A, PHE41A, PHE76B, PRO179A, PRO215A, PRO224A, PRO96B, SER102B, SER106B, SER119B, SER122B, SER124A, SER126B, SER128B, SER130A, SER132B, SER136B, SER140A, SER148B, SER149A, SER151B, SER162B, SER171B, SER214B, SER220A, SER28A, SER34A, SER87B, THR114A, THR118A, THR134B, THR137A, THR142A, THR144B, THR152A, THR18A, THR212B, THR22A, THR23A, THR25A, THR38A, THR57A, TRP156B, TRP177A, TYR111B, TYR117A, TYR131B, TYR137B, TYR145A, TYR150A, TYR173B, TYR20A, TYR246A, TYR41B, TYR83A, TYR94B, VAL105B, VAL111A, VAL143B, VAL146B, VAL154B, VAL167A, VAL17A, VAL288A, VAL36B, VAL89B
• A-H: ALA103H, ALA120H, ALA138A, ALA160H, ALA169A, ALA26H, ARG151A, ARG156A, ARG16H, ARG182A, ARG188H, ARG231H, ARG233A, ARG57H, ASN104A, ASN106A, ASN112H, ASN113A, ASN116H, ASN127A, ASN130H, ASN134A, ASN136A, ASN138H, ASN141H, ASN144A, ASN157A, ASN159A, ASN161H, ASN162A, ASN167H, ASN191A, ASN195H, ASN206H, ASN30H, ASN96A, ASP104H, ASP122A, ASP181H, ASP183A, ASP189H, ASP194H, ASP19H, ASP34H, ASP44A, ASP48A, ASP50A, ASP99A, GLN105A, GLN107H, GLN110A, GLN112A, GLN118H, GLN139H, GLN147A, GLN169H, GLN180H, GLN18H, GLN196H, GLN202H, GLN29H, GLN32H, GLN51H, GLU107A, GLU108A, GLU12H, GLU141A, GLU148A, GLU168A, GLU271H, GLY110H, GLY114H, GLY115H, GLY116A, GLY120A, GLY121A, GLY124H, GLY125H, GLY127H, GLY131A, GLY135A, GLY164A, GLY166A, GLY168H, GLY178A, GLY181A, GLY184H, GLY190A, GLY204H, GLY52H, HIS170A, HIS186A, HIS232A, HIS270H, ILE123A, ILE123H, ILE125A, ILE135H, ILE13H, ILE143A, ILE14H, ILE172A, ILE201H, ILE20H, ILE274H, ILE27H, ILE31H, ILE42A, ILE54H, ILE73H, LEU109H, LEU115A, LEU129A, LEU133A, LEU154A, LEU193A, LEU197H, LEU200H, LEU230A, LYS103A, LYS108H, LYS133H, LYS140H, LYS146A, LYS159H, LYS15H, LYS161A, LYS171A, LYS23H, LYS268A, LYS273H, LYS45A, LYS49A, LYS49H, LYS82A, MET233H, MET72H, PHE109A, PHE117H, PHE119A, PHE129H, PHE139A, PHE163H, PHE185A, PHE191H, PHE205H, PHE33H, PHE35H, PHE53H, PRO102A, PRO121H, PRO166H, PRO179A, PRO182H, PRO187A, PRO193H, PRO198H, PRO199H, PRO207H, PRO75H, SER106H, SER122H, SER124A, SER126A, SER126H, SER128H, SER130A, SER132H, SER136H, SER140A, SER149A, SER155A, SER162H, SER171H, SER184A, SER203H, SER208H, SER22H, SER231A, SER46A, SER55H, SER56H, SER91A, THR114A, THR118A, THR134H, THR137A, THR142A, THR144H, THR152A, THR153A, THR158A, THR165H, THR17H, THR183H, THR21H, THR28H, THR51A, THR58H, THR59H, TRP165A, TRP74H, TYR100A, TYR111H, TYR117A, TYR131H, TYR137H, TYR142H, TYR145A, TYR150A, TYR160A, TYR180A, TYR47A, TYR60H, TYR78H, VAL105H, VAL111A, VAL143H, VAL158H, VAL163A, VAL164H, VAL170H, VAL17A, VAL192H, VAL229A, VAL272H, VAL95A, VAL97A, VAL98A
• C-E: ASN113E, ASN175C, GLY176C, GLY178C, LEU115E, MET173C, PHE139E, TRP177C
• C-B: ALA103B, ALA120B, ALA138C, ALA160B, ALA169C, ALA26B, ARG151C, ARG156C, ARG16B, ARG182C, ARG188B, ARG231B, ARG233C, ARG57B, ASN104C, ASN106C, ASN112B, ASN113C, ASN116B, ASN127C, ASN130B, ASN134C, ASN136C, ASN138B, ASN141B, ASN144C, ASN157C, ASN159C, ASN161B, ASN162C, ASN167B, ASN191C, ASN195B, ASN206B, ASN30B, ASN96C, ASP104B, ASP122C, ASP181B, ASP183C, ASP189B, ASP194B, ASP19B, ASP34B, ASP44C, ASP48C, ASP50C, ASP99C, GLN105C, GLN107B, GLN110C, GLN112C, GLN118B, GLN139B, GLN147C, GLN169B, GLN180B, GLN18B, GLN196B, GLN202B, GLN29B, GLN32B, GLN51B, GLU107C, GLU108C, GLU12B, GLU141C, GLU148C, GLU168C, GLU271B, GLY110B, GLY114B, GLY115B, GLY116C, GLY120C, GLY121C, GLY124B, GLY125B, GLY127B, GLY131C, GLY135C, GLY164C, GLY166C, GLY168B, GLY178C, GLY181C, GLY184B, GLY190C, GLY204B, GLY52B, HIS170C, HIS186C, HIS232C, HIS270B, ILE123B, ILE123C, ILE125C, ILE135B, ILE13B, ILE143C, ILE14B, ILE172C, ILE201B, ILE20B, ILE274B, ILE27B, ILE31B, ILE42C, ILE54B, ILE73B, LEU109B, LEU115C, LEU129C, LEU133C, LEU154C, LEU193C, LEU197B, LEU200B, LEU230C, LYS103C, LYS108B, LYS133B, LYS140B, LYS146C, LYS159B, LYS15B, LYS161C, LYS171C, LYS23B, LYS268C, LYS273B, LYS45C, LYS49B, LYS49C, LYS82C, MET233B, PHE109C, PHE119C, PHE129B, PHE139C, PHE163B, PHE185C, PHE191B, PHE205B, PHE33B, PHE35B, PHE53B, PRO102C, PRO121B, PRO166B, PRO179C, PRO182B, PRO187C, PRO193B, PRO198B, PRO199B, PRO207B, PRO75B, SER106B, SER122B, SER124C, SER126B, SER126C, SER128B, SER130C, SER132B, SER136B, SER140C, SER149C, SER155C, SER162B, SER171B, SER184C, SER203B, SER208B, SER22B, SER231C, SER46C, SER55B, SER56B, SER91C, THR114C, THR118C, THR134B, THR137C, THR142C, THR144B, THR152C, THR153C, THR158C, THR165B, THR17B, THR183B, THR21B, THR28B, THR51C, THR58B, THR59B, TRP165C, TRP74B, TYR100C, TYR111B, TYR117C, TYR131B, TYR137B, TYR142B, TYR145C, TYR150C, TYR160C, TYR180C, TYR47C, TYR60B, TYR78B, VAL105B, VAL111C, VAL143B, VAL158B, VAL163C, VAL164B, VAL170B, VAL17C, VAL192B, VAL229C, VAL272B, VAL95C, VAL97C, VAL98C
• C-D: ALA103D, ALA11D, ALA120D, ALA138C, ALA160D, ALA169C, ALA172D, ALA210C, ALA24C, ALA26C, ALA45D, ARG151C, ARG219C, ASN112D, ASN113C, ASN116D, ASN130D, ASN134C, ASN136C, ASN144C, ASN150D, ASN161D, ASN175C, ASN221C, ASN223C, ASN285C, ASN40C, ASN42D, ASN59C, ASN61C, ASN93D, ASN98D, ASP101D, ASP104D, ASP122C, ASP174D, ASP27C, ASP29C, ASP38D, ASP44D, ASP90D, GLN107D, GLN110C, GLN112C, GLN118D, GLN147C, GLN149D, GLN211C, GLN213C, GLN35C, GLU141C, GLU145D, GLU147D, GLU148C, GLU168C, GLU216D, GLU225C, GLY110D, GLY114D, GLY115D, GLY116C, GLY120C, GLY121C, GLY124D, GLY125D, GLY127D, GLY131C, GLY132C, GLY135C, GLY153D, GLY176C, GLY178C, GLY58C, HIS170C, HIS212C, HIS215D, HIS251D, HIS286C, ILE100D, ILE113D, ILE123C, ILE123D, ILE135D, ILE143C, ILE172C, ILE33C, ILE36C, ILE60C, ILE92D, LEU109D, LEU115C, LEU129C, LEU133C, LEU19C, LEU213D, LEU216C, LEU217C, LEU290C, LEU37C, LEU91D, LEU95D, LYS108D, LYS133D, LYS146C, LYS152D, LYS155D, LYS159D, LYS171C, LYS219D, LYS21C, LYS255D, LYS287C, LYS289C, LYS32C, LYS39D, LYS40D, LYS43D, LYS55C, LYS66C, LYS83D, LYS97D, LYS99D, MET173C, MET214C, PHE109C, PHE117D, PHE119C, PHE129D, PHE139C, PHE222C, PHE226C, PHE39C, PHE41C, PHE76D, PRO121D, PRO179C, PRO215C, PRO224C, PRO96D, SER102D, SER106D, SER119D, SER122D, SER124C, SER126D, SER128D, SER130C, SER132D, SER136D, SER140C, SER148D, SER149C, SER151D, SER162D, SER171D, SER214D, SER220C, SER28C, SER34C, THR114C, THR118C, THR134D, THR137C, THR142C, THR144D, THR152C, THR18C, THR212D, THR22C, THR23C, THR25C, THR38C, THR57C, TRP156D, TRP177C, TYR111D, TYR117C, TYR131D, TYR137D, TYR145C, TYR150C, TYR173D, TYR20C, TYR246C, TYR41D, TYR83C, TYR94D, VAL105D, VAL111C, VAL143D, VAL146D, VAL154D, VAL167C, VAL288C, VAL36D, VAL89D
• E-G: ASN113G, ASN175E, GLY176E, GLY178E, LEU115G, MET173E, PHE139G, TRP177E
• E-D: ALA103D, ALA120D, ALA138E, ALA160D, ALA169E, ALA26D, ARG151E, ARG156E, ARG16D, ARG182E, ARG188D, ARG231D, ARG233E, ARG57D, ASN104E, ASN106E, ASN112D, ASN113E, ASN116D, ASN127E, ASN130D, ASN134E, ASN136E, ASN138D, ASN141D, ASN144E, ASN157E, ASN159E, ASN161D, ASN162E, ASN167D, ASN191E, ASN195D, ASN206D, ASN30D, ASN96E, ASP104D, ASP122E, ASP181D, ASP183E, ASP189D, ASP194D, ASP19D, ASP34D, ASP44E, ASP48E, ASP50E, ASP99E, GLN105E, GLN107D, GLN110E, GLN112E, GLN118D, GLN139D, GLN147E, GLN169D, GLN180D, GLN18D, GLN196D, GLN202D, GLN29D, GLN32D, GLN51D, GLU107E, GLU108E, GLU12D, GLU141E, GLU148E, GLU168E, GLU271D, GLY110D, GLY114D, GLY115D, GLY116E, GLY120E, GLY121E, GLY124D, GLY125D, GLY127D, GLY128E, GLY131E, GLY135E, GLY164E, GLY166E, GLY168D, GLY178E, GLY181E, GLY184D, GLY190E, GLY204D, GLY52D, HIS170E, HIS186E, HIS232E, HIS270D, ILE123D, ILE123E, ILE125E, ILE135D, ILE13D, ILE143E, ILE14D, ILE172E, ILE201D, ILE20D, ILE274D, ILE27D, ILE31D, ILE42E, ILE54D, ILE73D, LEU109D, LEU115E, LEU129E, LEU133E, LEU154E, LEU193E, LEU197D, LEU200D, LEU230E, LYS103E, LYS108D, LYS133D, LYS140D, LYS146E, LYS159D, LYS15D, LYS161E, LYS171E, LYS23D, LYS268E, LYS273D, LYS45E, LYS49D, LYS49E, LYS82E, MET233D, MET72D, PHE109E, PHE119E, PHE129D, PHE139E, PHE163D, PHE185E, PHE191D, PHE205D, PHE33D, PHE35D, PHE53D, PRO102E, PRO121D, PRO166D, PRO179E, PRO182D, PRO187E, PRO193D, PRO198D, PRO199D, PRO207D, PRO75D, SER106D, SER122D, SER124E, SER126D, SER126E, SER128D, SER130E, SER132D, SER136D, SER140E, SER149E, SER155E, SER162D, SER171D, SER184E, SER203D, SER208D, SER22D, SER231E, SER46E, SER55D, SER56D, SER91E, THR114E, THR118E, THR134D, THR137E, THR142E, THR144D, THR152E, THR153E, THR158E, THR165D, THR17D, THR183D, THR21D, THR28D, THR51E, THR58D, THR59D, TRP165E, TRP74D, TYR100E, TYR111D, TYR117E, TYR131D, TYR137D, TYR142D, TYR145E, TYR150E, TYR160E, TYR180E, TYR47E, TYR60D, TYR78D, VAL105D, VAL111E, VAL143D, VAL158D, VAL163E, VAL164D, VAL170D, VAL17E, VAL192D, VAL229E, VAL272D, VAL95E, VAL97E, VAL98E
• E-F: ALA103F, ALA11F, ALA120F, ALA138E, ALA160F, ALA169E, ALA172F, ALA210E, ALA24E, ALA26E, ALA45F, ARG151E, ARG219E, ASN112F, ASN113E, ASN116F, ASN130F, ASN134E, ASN136E, ASN144E, ASN150F, ASN161F, ASN175E, ASN221E, ASN223E, ASN285E, ASN40E, ASN42F, ASN59E, ASN61E, ASN93F, ASN98F, ASP101F, ASP104F, ASP122E, ASP174F, ASP27E, ASP282E, ASP29E, ASP38F, ASP44F, ASP90F, GLN107F, GLN110E, GLN112E, GLN118F, GLN139F, GLN147E, GLN149F, GLN169F, GLN211E, GLN213E, GLN35E, GLU141E, GLU145F, GLU147F, GLU148E, GLU168E, GLU216F, GLU225E, GLY110F, GLY114F, GLY115F, GLY116E, GLY120E, GLY121E, GLY124F, GLY125F, GLY127F, GLY131E, GLY132E, GLY135E, GLY153F, GLY176E, GLY178E, GLY58E, HIS170E, HIS212E, HIS215F, HIS251F, HIS286E, ILE100F, ILE113F, ILE123E, ILE123F, ILE135F, ILE143E, ILE172E, ILE33E, ILE36E, ILE60E, ILE92F, LEU109F, LEU115E, LEU129E, LEU133E, LEU19E, LEU213F, LEU216E, LEU217E, LEU290E, LEU37E, LEU91F, LEU95F, LYS108F, LYS133F, LYS146E, LYS152F, LYS155F, LYS159F, LYS171E, LYS21E, LYS287E, LYS289E, LYS32E, LYS39F, LYS40F, LYS43F, LYS55E, LYS83F, LYS97F, LYS99F, MET173E, MET214E, PHE109E, PHE117F, PHE119E, PHE129F, PHE139E, PHE222E, PHE226E, PHE39E, PHE41E, PHE76F, PRO102E, PRO121F, PRO179E, PRO215E, PRO224E, PRO96F, SER102F, SER106F, SER119F, SER122F, SER124E, SER126F, SER128F, SER130E, SER132F, SER136F, SER140E, SER148F, SER149E, SER151F, SER162F, SER171F, SER214F, SER220E, SER28E, SER34E, SER87F, THR114E, THR118E, THR134F, THR137E, THR142E, THR144F, THR152E, THR18E, THR212F, THR22E, THR23E, THR25E, THR38E, THR57E, TRP156F, TRP177E, TYR111F, TYR117E, TYR131F, TYR137F, TYR145E, TYR150E, TYR173F, TYR20E, TYR246E, TYR41F, TYR83E, TYR94F, VAL105F, VAL111E, VAL143F, VAL146F, VAL154F, VAL167E, VAL17E, VAL288E, VAL36F, VAL89F
• G-F: ALA103F, ALA120F, ALA138G, ALA160F, ALA169G, ALA26F, ARG151G, ARG156G, ARG16F, ARG182G, ARG188F, ARG231F, ARG233G, ARG57F, ASN104G, ASN106G, ASN112F, ASN113G, ASN116F, ASN127G, ASN130F, ASN134G, ASN136G, ASN138F, ASN141F, ASN144G, ASN157G, ASN159G, ASN161F, ASN162G, ASN167F, ASN195F, ASN206F, ASN30F, ASN96G, ASP104F, ASP122G, ASP181F, ASP183G, ASP189F, ASP194F, ASP19F, ASP34F, ASP44G, ASP48G, ASP50G, ASP99G, GLN105G, GLN107F, GLN110G, GLN112G, GLN118F, GLN139F, GLN147G, GLN169F, GLN180F, GLN18F, GLN196F, GLN202F, GLN29F, GLN32F, GLN51F, GLU107G, GLU108G, GLU12F, GLU141G, GLU148G, GLU168G, GLU271F, GLY110F, GLY114F, GLY115F, GLY116G, GLY120G, GLY121G, GLY124F, GLY125F, GLY127F, GLY128G, GLY131G, GLY135G, GLY164G, GLY166G, GLY168F, GLY178G, GLY181G, GLY184F, GLY190G, GLY204F, GLY52F, HIS170G, HIS186G, HIS232G, HIS270F, ILE123F, ILE123G, ILE125G, ILE135F, ILE13F, ILE143G, ILE14F, ILE172G, ILE201F, ILE20F, ILE274F, ILE27F, ILE31F, ILE42G, ILE54F, ILE73F, LEU109F, LEU115G, LEU129G, LEU133G, LEU154G, LEU193G, LEU197F, LEU200F, LEU230G, LYS103G, LYS108F, LYS133F, LYS140F, LYS146G, LYS159F, LYS15F, LYS161G, LYS171G, LYS23F, LYS268G, LYS273F, LYS45G, LYS49F, LYS49G, LYS82G, MET233F, MET72F, PHE109G, PHE117F, PHE119G, PHE129F, PHE139G, PHE163F, PHE185G, PHE191F, PHE205F, PHE33F, PHE35F, PHE53F, PRO102G, PRO121F, PRO166F, PRO179G, PRO182F, PRO187G, PRO193F, PRO198F, PRO199F, PRO207F, PRO75F, SER106F, SER122F, SER124G, SER126F, SER126G, SER128F, SER130G, SER132F, SER136F, SER140G, SER149G, SER155G, SER162F, SER171F, SER184G, SER203F, SER208F, SER22F, SER231G, SER46G, SER55F, SER56F, SER91G, THR114G, THR118G, THR134F, THR137G, THR142G, THR144F, THR152G, THR153G, THR158G, THR165F, THR17F, THR183F, THR21F, THR28F, THR51G, THR58F, THR59F, TRP165G, TRP74F, TYR100G, TYR111F, TYR117G, TYR131F, TYR137F, TYR142F, TYR145G, TYR150G, TYR160G, TYR180G, TYR47G, TYR60F, TYR78F, VAL105F, VAL111G, VAL143F, VAL158F, VAL163G, VAL164F, VAL170F, VAL17G, VAL192F, VAL229G, VAL272F, VAL95G, VAL97G, VAL98G
• G-H: ALA103H, ALA11H, ALA120H, ALA138G, ALA160H, ALA169G, ALA172H, ALA210G, ALA24G, ALA26G, ALA45H, ARG151G, ARG219G, ASN112H, ASN113G, ASN116H, ASN130H, ASN134G, ASN136G, ASN144G, ASN150H, ASN161H, ASN175G, ASN221G, ASN223G, ASN285G, ASN40G, ASN42H, ASN59G, ASN61G, ASN93H, ASN98H, ASP101H, ASP104H, ASP122G, ASP174H, ASP27G, ASP282G, ASP29G, ASP38H, ASP44H, ASP90H, GLN107H, GLN110G, GLN112G, GLN118H, GLN147G, GLN149H, GLN169H, GLN211G, GLN213G, GLN35G, GLU141G, GLU145H, GLU147H, GLU148G, GLU168G, GLU216H, GLU225G, GLY110H, GLY114H, GLY115H, GLY116G, GLY120G, GLY121G, GLY124H, GLY125H, GLY127H, GLY131G, GLY132G, GLY135G, GLY153H, GLY176G, GLY178G, GLY58G, HIS170G, HIS212G, HIS215H, HIS251H, HIS286G, ILE100H, ILE113H, ILE123G, ILE123H, ILE135H, ILE143G, ILE172G, ILE33G, ILE36G, ILE60G, ILE92H, LEU109H, LEU115G, LEU129G, LEU133G, LEU19G, LEU213H, LEU216G, LEU217G, LEU290G, LEU37G, LEU91H, LEU95H, LYS108H, LYS133H, LYS146G, LYS152H, LYS155H, LYS159H, LYS171G, LYS219H, LYS21G, LYS287G, LYS289G, LYS32G, LYS39H, LYS40H, LYS43H, LYS55G, LYS83H, LYS97H, LYS99H, MET173G, MET214G, PHE109G, PHE117H, PHE119G, PHE129H, PHE139G, PHE222G, PHE226G, PHE39G, PHE41G, PHE76H, PRO121H, PRO179G, PRO215G, PRO224G, PRO96H, SER102H, SER106H, SER119H, SER122H, SER124G, SER126H, SER128H, SER130G, SER132H, SER136H, SER140G, SER148H, SER149G, SER151H, SER162H, SER171H, SER214H, SER220G, SER28G, SER34G, SER87H, THR114G, THR118G, THR134H, THR137G, THR142G, THR144H, THR152G, THR18G, THR212H, THR22G, THR23G, THR25G, THR38G, THR57G, TRP156H, TRP177G, TYR111H, TYR117G, TYR131H, TYR137H, TYR145G, TYR150G, TYR173H, TYR20G, TYR246G, TYR41H, TYR83G, TYR94H, VAL105H, VAL111G, VAL143H, VAL146H, VAL154H, VAL167G, VAL17G, VAL288G, VAL36H, VAL89H
• B-D: ASN167B, GLN107D, GLN169B, GLY168B, LEU109D, LYS108D, LYS133D, PHE129D, PRO166B, THR165B, TYR111D, TYR131D, VAL105D, VAL164B
• B-H: ASN167H, GLN107B, GLN169H, GLY168H, LEU109B, LYS108B, LYS133B, PHE129B, PRO166H, SER132B, THR165H, TYR111B, TYR131B, VAL105B, VAL164H
• D-F: ASN167D, GLN107F, GLN169D, GLY168D, LEU109F, LYS108F, LYS133F, PHE129F, PRO166D, THR165D, TYR111F, TYR131F, VAL105F, VAL164D
• F-H: ASN167F, GLN107H, GLN169F, GLY168F, LEU109H, LYS108H, LYS133H, PHE129H, PRO166F, THR165F, TYR111H, TYR131H, VAL105H, VAL164F