3AOG

crystal structure of glutamate dehydrogenase (gdhb) from thermus thermophilus (glu bound form)

• Total interactions analyzed: 66
• Total true interactions: 35
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 144
  • Norm. En. per Res.: -4.021
• Hub Node: A(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-93.7456	-101.6932	-395.494	-590.9328	150	21	10	17144	4	45	37
A-C	-39.5963	-57.8879	-208.058	-305.5422	97	6	7	9122	3	18	22
A-D	0.0	0.0	-8.8679	-8.8679	31	0	0	738	0	13	14
A-E	-15.6849	-35.0956	-238.161	-288.9414	99	5	7	9195	1	18	22
A-F	0.0	0.0	-11.4332	-11.4332	4	0	0	370	0	0	0
A-G	0.0	56.6432	-87.3524	-30.7092	74	2	0	3556	2	46	47
A-H	0.0	0.2236	-12.4942	-12.2706	36	0	1	1093	1	24	22
A-I	-7.4506	-19.3315	-59.0309	-85.813	46	3	0	2007	6	31	25
B-C	0.0	0.0	-10.7313	-10.7313	4	0	0	362	0	0	0
B-D	-43.3597	-50.9772	-237.856	-332.193	98	8	7	9223	2	18	22
B-E	0.0	0.0	-7.8971	-7.8971	28	0	0	657	0	13	14
B-F	-22.0002	-43.0157	-232.949	-297.9649	97	9	7	9163	1	19	21
C-D	-70.8058	-98.7315	-397.216	-566.7532	143	18	10	17260	1	42	35
C-E	-13.574	-39.4886	-235.595	-288.6577	100	3	7	9220	2	20	22
C-F	0.0	0.0	-10.6649	-10.6649	30	0	0	808	0	14	14
C-G	0.0	-17.4893	-15.5155	-33.0048	37	0	1	1171	4	22	23
D-E	0.0	0.0	-10.7377	-10.7377	4	0	0	360	0	0	0
D-F	-24.2857	-59.651	-227.486	-311.4228	96	8	7	9190	2	18	22
E-F	-82.8329	-111.2517	-384.946	-579.0307	144	25	11	17065	4	47	38
E-G	-5.6415	-20.8333	-56.0443	-82.5191	48	1	0	2079	3	30	26
G-H	-17.1938	-27.5563	-234.193	-278.9431	101	5	7	9257	1	18	22
G-I	-8.1343	-43.2121	-229.797	-281.1435	99	8	7	9083	2	18	22
G-J	-87.7997	-88.1629	-378.656	-554.6186	149	25	10	17046	0	47	36
G-K	0.0	0.0	-10.4527	-10.4527	4	0	0	366	0	0	0
G-L	0.0	0.0	-7.4506	-7.4506	30	0	0	631	0	14	14
H-I	-26.1723	-47.2701	-223.489	-296.9313	94	6	7	8956	2	19	22
H-J	0.0	0.0	-10.7847	-10.7847	4	2	0	363	0	0	0
H-K	0.0	0.0	-9.2132	-9.2132	32	0	0	690	0	13	15
H-L	-77.59	-86.7484	-380.074	-544.4124	148	19	10	16788	1	44	34
I-J	0.0	0.0	-6.4921	-6.4921	28	0	0	531	0	14	14
I-K	-84.7948	-111.5184	-388.745	-585.0583	146	17	10	17193	5	46	38
I-L	0.0	0.0	-12.7251	-12.7251	4	0	0	381	0	0	0
J-K	-27.7736	-51.0677	-233.414	-312.2553	96	9	7	9249	2	18	20
J-L	-18.537	-33.5501	-230.318	-282.405	99	12	7	9114	1	19	22
K-L	-21.723	-55.0704	-239.731	-316.5244	102	12	7	9504	3	18	22

Interface residues

• A-B: ALA37A, ALA37B, ALA61A, ALA61B, ARG118A, ARG118B, ARG131A, ARG131B, ARG134A, ARG134B, ARG135A, ARG135B, ARG148A, ARG148B, ARG417A, ARG417B, ARG420A, ARG420B, ARG42A, ARG42B, ARG45A, ARG45B, ARG54A, ARG54B, ARG67A, ARG67B, ASN172A, ASN172B, ASP12A, ASP50A, ASP50B, CB8.31334-65.39217, CB8.3289854.43164, GLU139A, GLU139B, GLU38A, GLU38B, GLU4A, GLU4A5, GLU4B, GLU64A, GLU64B, GLU86A, GLU86B, GLY10A, GLY10B, GLY141A, GLY141B, GLY421A, GLY421B, GLY58A, GLY58B, GLY65A, GLY65B, HIS69A, HIS69B, HIS70A, HIS70B, ILE140A, ILE140B, ILE142A, ILE142B, ILE48A, ILE48B, LEU143A, LEU143B, LEU36A, LEU36B, LEU40A, LEU40B, LEU414A, LEU414B, LEU422A, LEU422B, LEU47A, LEU47B, LEU55A, LEU55B, LEU6A, LEU6B, LEU89A, LEU89B, LEU9A, LEU9B, LYS41A, LYS41B, LYS44A, LYS44B, MET171A, MET171B, MET93A, MET93B, PHE63A, PHE63B, PRO35A, PRO35B, PRO424A, PRO424B, PRO43A, PRO43B, PRO52A, PRO52B, PRO5A, PRO5B, PRO85A, PRO85B, SER138A, SER138B, SER39A, SER39B, SER59A, SER59B, SER7A, SER7B, SER90A, SER90B, THR137A, THR137B, THR168A, THR168B, THR72A, THR72B, THR88A, THR88B, TYR136A, TYR136B, TYR423A, TYR423B, TYR62A, TYR62B, TYR66A, TYR66B, TYR8A, TYR8B, VAL119A, VAL119B, VAL46A, VAL46B, VAL49A, VAL49B, VAL51A, VAL51B, VAL53A, VAL53B, VAL60A, VAL60B, VAL68A, VAL68B, VAL87A, VAL87B
• A-C: ALA163A, ALA187A, ALA377C, ALA416C, ALA418C, ALA73C, ALA77C, ARG131A, ARG134A, ARG135A, ARG148C, ARG160A, ARG175A, ARG378A, ARG378C, ARG381C, ARG412C, ARG417C, ARG420C, ARG45C, ARG74C, ASN172A, ASN366A, ASN366C, ASN385C, ASP147C, ASP149C, ASP167A, ASP364A, ASP364C, GLN363A, GLN363C, GLU130A, GLU159A, GLU372A, GLU374A, GLU374C, GLU415C, GLY107C, GLY111C, GLY145C, GLY174A, GLY189A, GLY421C, GLY75C, ILE150C, ILE186A, ILE375C, LEU108C, LEU144C, LEU188A, LEU192A, LEU379C, LEU419C, LEU422C, LYS184A, LYS44C, MET162A, MET165A, MET166A, MET171A, PHE359C, PHE365A, PHE365C, PHE369A, PRO109C, PRO146C, PRO178A, PRO185A, PRO424C, PRO76C, SER138A, SER170A, SER367A, THR137A, THR168A, THR176A, THR355C, THR371A, THR411C, THR72C, TRP164A, TRP361C, TRP370A, TRP370C, TYR110C, TYR169A, TYR358C, TYR368A, TYR368C, TYR423C, VAL173A, VAL177A, VAL362A, VAL362C, VAL382C, VAL413C
• A-D: ARG131A, ARG131D, ARG134A, ARG134D, ARG135A, ARG135D, ARG54A, ARG54D, ASN172A, ASN172D, ASP167A, ASP167D, GLU130A, GLU130D, GLU139A, GLU139D, GLY127A, GLY127D, GLY141A, GLY141D, GLY174A, GLY174D, ILE142A, ILE142D, MET171A, MET171D, PRO52D, SER138A, SER138D, VAL173A, VAL173D
• A-E: ALA163E, ALA187E, ALA377A, ALA416A, ALA418A, ALA73A, ALA77A, ARG131E, ARG134E, ARG135E, ARG148A, ARG160E, ARG175E, ARG378A, ARG378E, ARG381A, ARG412A, ARG417A, ARG420A, ARG45A, ARG74A, ASN172E, ASN366A, ASN366E, ASN385A, ASP147A, ASP149A, ASP167E, ASP364A, ASP364E, GLN363A, GLN363E, GLU130E, GLU159E, GLU161E, GLU372E, GLU373E, GLU374A, GLU374E, GLU415A, GLY107A, GLY111A, GLY145A, GLY174E, GLY189E, GLY421A, GLY75A, ILE186E, ILE375A, LEU108A, LEU143A, LEU144A, LEU188E, LEU192E, LEU379A, LEU419A, LEU422A, LYS184E, LYS44A, MET162E, MET165E, MET166E, MET171E, PHE359A, PHE365A, PHE365E, PHE369E, PRO109A, PRO146A, PRO178E, PRO185E, PRO424A, PRO76A, SER138E, SER170E, SER367E, THR137E, THR168E, THR176E, THR355A, THR371E, THR411A, THR72A, TRP164E, TRP361A, TRP370A, TRP370E, TYR110A, TYR169E, TYR358A, TYR368A, TYR368E, TYR423A, VAL173E, VAL177E, VAL362A, VAL362E, VAL382A, VAL413A
• A-F: PRO424A, PRO424F, TYR423A, TYR423F
• A-G: ALA207G, ALA208A, ALA208G, ALA210A, ALA220A, ALA220G, ALA243A, ALA243G, ALA259A, ALA259G, ALA377A, ALA377G, ARG200A, ARG200G, ARG244A, ARG244G, ARG378A, ARG378G, ARG381A, ARG381G, ARG384A, ARG384G, ASN376A, ASN376G, ASN385A, ASN385G, ASP240A, ASP240G, GLN216A, GLN216G, GLU211A, GLU211G, GLU218A, GLU218G, GLU372A, GLU372G, GLU373A, GLU373G, GLU374A, GLU374G, GLU380A, GLU380G, GLU388A, GLU388G, GLY214A, GLY214G, GLY219A, GLY219G, GLY242A, GLY242G, HIS239A, HIS239G, HIS241A, HIS241G, ILE204A, ILE204G, ILE375A, ILE375G, LEU215A, LEU215G, LEU379A, LEU379G, LEU383A, LEU383G, LYS212A, LYS212G, PHE203A, PHE203G, THR371A, THR371G, VAL217A, VAL217G, VAL382A, VAL382G
• A-H: ALA207H, ALA208H, ALA259A, ALA282A, ALA377H, ARG221A, ARG277A, ARG378H, ARG381H, ARG384H, ASN257A, ASN376H, ASP240H, GLN216H, GLU211H, GLU218H, GLU258A, GLU272A, GLU283A, GLU373H, GLU374H, GLU380H, GLY219H, GLY242H, GLY260A, GLY278A, HIS241H, HIS269A, LYS281A, PHE203H, PHE273A, PRO280A, PRO284A, TYR256A, TYR279A, VAL217H
• A-I: ALA243I, ALA377I, ARG221A, ARG236I, ARG244A, ARG244I, ARG314A, ARG316A, ARG318A, ARG378I, ARG381I, ARG384I, ASN376I, ASP240I, ASP262I, GLN216A, GLN216I, GLN310A, GLU218I, GLU296A, GLU309A, GLU338A, GLU372I, GLU373I, GLU374I, GLU380I, GLY214A, GLY219I, GLY242I, GLY340A, HIS239I, HIS241I, ILE204I, ILE213A, ILE315A, ILE335A, LEU215A, LEU337A, LYS339A, PHE203I, PHE238I, PRO294A, THR371I, TRP313A, TYR264I, VAL217I
• B-C: PRO424B, PRO424C, TYR423B, TYR423C
• B-D: ALA163D, ALA187D, ALA377B, ALA416B, ALA418B, ALA73B, ALA77B, ARG131D, ARG134D, ARG135D, ARG148B, ARG160D, ARG175D, ARG378B, ARG378D, ARG381B, ARG412B, ARG417B, ARG420B, ARG45B, ARG74B, ASN172D, ASN366B, ASN366D, ASN385B, ASP147B, ASP149B, ASP167D, ASP364B, ASP364D, GLN363B, GLN363D, GLU130D, GLU159D, GLU372D, GLU373D, GLU374B, GLU374D, GLU415B, GLY107B, GLY111B, GLY145B, GLY174D, GLY189D, GLY421B, GLY75B, ILE150B, ILE186D, ILE375B, LEU108B, LEU143B, LEU144B, LEU188D, LEU192D, LEU379B, LEU419B, LEU422B, LYS184D, LYS44B, MET162D, MET165D, MET166D, MET171D, PHE359B, PHE365B, PHE365D, PHE369D, PRO109B, PRO146B, PRO178D, PRO185D, PRO424B, PRO76B, SER138D, SER170D, SER367D, THR168D, THR176D, THR355B, THR371D, THR411B, THR72B, TRP164D, TRP361B, TRP370B, TRP370D, TYR110B, TYR169D, TYR358B, TYR368B, TYR368D, TYR423B, VAL173D, VAL177D, VAL362B, VAL362D, VAL382B, VAL413B
• B-E: ARG131B, ARG131E, ARG134B, ARG134E, ARG135B, ARG135E, ARG54B, ARG54E, ASN172B, ASN172E, ASP167B, ASP167E, GLU130B, GLU130E, GLU139B, GLU139E, GLY127E, GLY174B, GLY174E, ILE142B, ILE142E, MET171B, MET171E, PRO52E, SER138B, SER138E, VAL173B, VAL173E
• B-F: ALA163B, ALA187B, ALA377F, ALA416F, ALA418F, ALA73F, ALA77F, ARG131B, ARG134B, ARG135B, ARG148F, ARG160B, ARG175B, ARG378B, ARG378F, ARG381F, ARG412F, ARG417F, ARG420F, ARG45F, ARG74F, ASN172B, ASN366B, ASN366F, ASN385F, ASP147F, ASP149F, ASP167B, ASP364B, ASP364F, GLN363B, GLN363F, GLU130B, GLU159B, GLU372B, GLU373B, GLU374B, GLU374F, GLU415F, GLY107F, GLY145F, GLY174B, GLY189B, GLY421F, GLY75F, ILE186B, ILE375B, ILE375F, LEU108F, LEU144F, LEU188B, LEU192B, LEU379F, LEU419F, LEU422F, LYS184B, LYS44F, MET162B, MET165B, MET166B, MET171B, PHE359F, PHE365B, PHE365F, PHE369B, PRO109F, PRO146F, PRO178B, PRO185B, PRO424F, PRO76F, SER138B, SER170B, SER367B, THR137B, THR168B, THR176B, THR355F, THR371B, THR411F, THR72F, TRP164B, TRP361F, TRP370B, TRP370F, TYR110F, TYR169B, TYR358F, TYR368B, TYR368F, TYR423F, VAL173B, VAL177B, VAL362B, VAL362F, VAL382F, VAL413F
• C-D: ALA37C, ALA37D, ALA61C, ALA61D, ARG118C, ARG118D, ARG131C, ARG131D, ARG134C, ARG134D, ARG135C, ARG135D, ARG148C, ARG148D, ARG417C, ARG417D, ARG420C, ARG420D, ARG42C, ARG42D, ARG45C, ARG45D, ARG54C, ARG54D, ARG67C, ARG67D, ASN172C, ASN172D, ASP50C, ASP50D, GLU139C, GLU139D, GLU38C, GLU38D, GLU4C, GLU4D, GLU64C, GLU64D, GLU86C, GLU86D, GLY141C, GLY141D, GLY421C, GLY421D, GLY58C, GLY58D, GLY65C, GLY65D, HIS69C, HIS69D, HIS70C, HIS70D, ILE140C, ILE140D, ILE142C, ILE142D, ILE48C, ILE48D, LEU143C, LEU143D, LEU36C, LEU36D, LEU40C, LEU40D, LEU414D, LEU422C, LEU422D, LEU47C, LEU47D, LEU55C, LEU55D, LEU6C, LEU6D, LEU89C, LEU89D, LEU9C, LEU9D, LYS41C, LYS41D, LYS44C, LYS44D, MET171C, MET171D, MET93C, MET93D, PHE63C, PHE63D, PRO35C, PRO35D, PRO424C, PRO424D, PRO43C, PRO43D, PRO52C, PRO52D, PRO5C, PRO5D, PRO85C, PRO85D, SER138C, SER138D, SER39C, SER39D, SER59C, SER59D, SER7C, SER7D, SER90C, SER90D, THR133C, THR137C, THR137D, THR168C, THR168D, THR72C, THR72D, THR88C, THR88D, TYR136C, TYR136D, TYR423C, TYR423D, TYR62C, TYR62D, TYR66C, TYR66D, TYR8C, TYR8D, VAL119D, VAL46C, VAL46D, VAL49C, VAL49D, VAL51C, VAL51D, VAL53C, VAL53D, VAL60C, VAL60D, VAL68C, VAL68D, VAL87C, VAL87D
• C-E: ALA163C, ALA187C, ALA377E, ALA416E, ALA418E, ALA73E, ALA77E, ARG131C, ARG134C, ARG135C, ARG148E, ARG160C, ARG175C, ARG378C, ARG378E, ARG381E, ARG412E, ARG417E, ARG420E, ARG45E, ARG74E, ASN172C, ASN366C, ASN366E, ASN385E, ASP147E, ASP149E, ASP167C, ASP364C, ASP364E, GLN363C, GLN363E, GLU130C, GLU159C, GLU161C, GLU372C, GLU373C, GLU374C, GLU374E, GLU415E, GLY107E, GLY111E, GLY145E, GLY174C, GLY189C, GLY421E, GLY75E, ILE186C, ILE375E, LEU108E, LEU143E, LEU144E, LEU188C, LEU192C, LEU379E, LEU419E, LEU422E, LYS184C, LYS44E, MET162C, MET165C, MET166C, MET171C, PHE359E, PHE365C, PHE365E, PHE369C, PRO109E, PRO146E, PRO178C, PRO185C, PRO424E, PRO76E, SER138C, SER170C, SER367C, THR137C, THR168C, THR176C, THR355E, THR371C, THR411E, THR72E, TRP164C, TRP361E, TRP370C, TRP370E, TYR110E, TYR169C, TYR169E, TYR358E, TYR368C, TYR368E, TYR423E, VAL173C, VAL177C, VAL362C, VAL362E, VAL382E, VAL413E
• C-F: ARG131C, ARG131F, ARG134C, ARG134F, ARG135C, ARG135F, ARG54C, ARG54F, ASN172C, ASN172F, ASP167C, ASP167F, GLU130C, GLU130F, GLU139C, GLU139F, GLY127C, GLY127F, GLY174C, GLY174F, ILE142C, ILE142F, MET171C, MET171F, PRO52C, PRO52F, SER138C, SER138F, VAL173C, VAL173F
• C-G: ALA207C, ALA208C, ALA237C, ALA259G, ALA282G, ALA377C, ARG200C, ARG221G, ARG277G, ARG378C, ARG381C, ARG384C, ASN257G, ASP240C, GLN216C, GLU211C, GLU218C, GLU258G, GLU272G, GLU283G, GLU373C, GLU374C, GLU380C, GLY242C, GLY260G, GLY278G, HIS241C, HIS269G, LYS212C, LYS281G, PHE203C, PHE273G, PRO280G, PRO284G, TYR256G, TYR279G, VAL217C
• D-E: PRO424D, PRO424E, TYR423D, TYR423E
• D-F: ALA163F, ALA187F, ALA377D, ALA416D, ALA418D, ALA73D, ALA77D, ARG131F, ARG134F, ARG135F, ARG148D, ARG160F, ARG175F, ARG378D, ARG378F, ARG381D, ARG412D, ARG417D, ARG420D, ARG45D, ARG74D, ASN172F, ASN366D, ASN366F, ASN385D, ASP147D, ASP167F, ASP364D, ASP364F, GLN363D, GLN363F, GLU130F, GLU159F, GLU161F, GLU372F, GLU373F, GLU374D, GLU374F, GLU415D, GLY107D, GLY111D, GLY145D, GLY174F, GLY189F, GLY421D, GLY75D, ILE186F, ILE375D, LEU108D, LEU144D, LEU188F, LEU192F, LEU379D, LEU419D, LEU422D, LYS184F, LYS44D, MET162F, MET165F, MET166F, MET171F, PHE359D, PHE365D, PHE365F, PHE369F, PRO109D, PRO146D, PRO178F, PRO185F, PRO424D, PRO76D, SER138F, SER170F, SER367F, THR137F, THR168F, THR176F, THR355D, THR371F, THR411D, THR72D, TRP164F, TRP361D, TRP370D, TRP370F, TYR110D, TYR169F, TYR358D, TYR368D, TYR368F, TYR423D, VAL173F, VAL177F, VAL362D, VAL382D, VAL413D
• E-F: ALA37E, ALA37F, ALA61E, ALA61F, ARG118E, ARG118F, ARG131E, ARG131F, ARG134E, ARG134F, ARG135E, ARG135F, ARG148E, ARG148F, ARG417E, ARG417F, ARG420E, ARG420F, ARG42E, ARG42F, ARG45E, ARG45F, ARG54E, ARG54F, ARG67E, ARG67F, ASN172E, ASN172F, ASP50E, ASP50F, GLU139E, GLU139F, GLU38E, GLU38F, GLU4E, GLU4F, GLU64E, GLU64F, GLU86E, GLU86F, GLY10E, GLY10F, GLY141E, GLY141F, GLY421E, GLY421F, GLY58E, GLY58F, GLY65E, GLY65F, HIS69E, HIS69F, HIS70E, HIS70F, ILE140E, ILE140F, ILE142E, ILE142F, ILE48E, ILE48F, LEU143E, LEU143F, LEU36E, LEU36F, LEU40E, LEU40F, LEU414E, LEU414F, LEU422E, LEU422F, LEU47E, LEU47F, LEU55E, LEU55F, LEU6E, LEU6F, LEU89E, LEU89F, LEU9E, LEU9F, LYS41E, LYS41F, LYS44E, LYS44F, MET171E, MET171F, MET93E, MET93F, PHE63E, PHE63F, PRO35E, PRO35F, PRO424E, PRO424F, PRO43E, PRO43F, PRO52E, PRO52F, PRO5E, PRO5F, PRO85E, PRO85F, SER138E, SER138F, SER39E, SER39F, SER59E, SER59F, SER7E, SER7F, SER90E, SER90F, THR137E, THR137F, THR168E, THR168F, THR72E, THR72F, THR88E, THR88F, TYR136E, TYR136F, TYR423E, TYR423F, TYR62E, TYR62F, TYR66E, TYR66F, TYR8E, TYR8F, VAL46E, VAL46F, VAL49E, VAL49F, VAL51E, VAL51F, VAL53E, VAL53F, VAL60E, VAL60F, VAL68E, VAL68F, VAL87E, VAL87F
• E-G: ALA243E, ALA312G, ALA377E, ARG221G, ARG236E, ARG244E, ARG268E, ARG314G, ARG316G, ARG318G, ARG378E, ARG381E, ARG384E, ASN376E, ASP240E, ASP262E, GLN216E, GLN216G, GLN310G, GLU218E, GLU296G, GLU309G, GLU338G, GLU372E, GLU373E, GLU374E, GLU380E, GLY219E, GLY242E, GLY340G, HIS239E, HIS241E, ILE204E, ILE213G, ILE315G, ILE335G, LEU215G, LEU337G, LYS339G, LYS398G, PHE203E, PHE238E, PRO263E, PRO294G, THR371E, TRP313G, TYR264E, VAL217E
• G-H: ALA163G, ALA187G, ALA377H, ALA416H, ALA418H, ALA73H, ALA77H, ARG131G, ARG134G, ARG135G, ARG148H, ARG160G, ARG175G, ARG175H, ARG378G, ARG378H, ARG381H, ARG412H, ARG417H, ARG420H, ARG45H, ARG74H, ASN172G, ASN366G, ASN366H, ASN385H, ASP147H, ASP149H, ASP167G, ASP364G, ASP364H, GLN363G, GLN363H, GLU130G, GLU159G, GLU161G, GLU372G, GLU374G, GLU374H, GLU415H, GLY107H, GLY111H, GLY145H, GLY174G, GLY189G, GLY190G, GLY421H, GLY75H, ILE150H, ILE186G, LEU108H, LEU143H, LEU144H, LEU188G, LEU192G, LEU379H, LEU419H, LEU422H, LYS184G, LYS44H, MET162G, MET165G, MET166G, MET171G, PHE359H, PHE365G, PHE365H, PHE369G, PRO109H, PRO146H, PRO178G, PRO185G, PRO424H, PRO76H, SER138G, SER170G, SER367G, THR137G, THR168G, THR176G, THR355H, THR371G, THR411H, THR72H, TRP164G, TRP361H, TRP370G, TRP370H, TYR110H, TYR169G, TYR169H, TYR358H, TYR368G, TYR368H, TYR423H, VAL173G, VAL177G, VAL362G, VAL362H, VAL382H, VAL413H
• G-I: ALA163I, ALA187I, ALA377G, ALA416G, ALA418G, ALA73G, ALA77G, ARG131I, ARG134I, ARG135I, ARG148G, ARG160I, ARG175I, ARG378G, ARG378I, ARG381G, ARG412G, ARG417G, ARG420G, ARG45G, ARG74G, ASN172I, ASN366G, ASN366I, ASN385G, ASP147G, ASP149G, ASP167I, ASP364G, ASP364I, GLN363G, GLN363I, GLU130I, GLU159I, GLU161I, GLU372I, GLU373I, GLU374G, GLU374I, GLU415G, GLY107G, GLY111G, GLY145G, GLY174I, GLY189I, GLY421G, GLY75G, ILE150G, ILE186I, ILE375G, LEU108G, LEU144G, LEU188I, LEU192I, LEU379G, LEU419G, LEU422G, LYS184I, LYS44G, MET162I, MET165I, MET166I, MET171I, PHE359G, PHE365G, PHE365I, PHE369I, PRO109G, PRO146G, PRO178I, PRO185I, PRO424G, PRO76G, SER138I, SER170I, SER367I, THR137I, THR168I, THR176I, THR355G, THR371I, THR411G, THR72G, TRP164I, TRP361G, TRP370G, TRP370I, TYR110G, TYR169I, TYR358G, TYR368G, TYR368I, TYR423G, VAL173I, VAL177I, VAL362G, VAL362I, VAL382G, VAL413G
• G-J: ALA37G, ALA37J, ALA61G, ALA61J, ARG118G, ARG118J, ARG131G, ARG131J, ARG134G, ARG134J, ARG135G, ARG135J, ARG148G, ARG148J, ARG417G, ARG417J, ARG420G, ARG420J, ARG42G, ARG42J, ARG45G, ARG45J, ARG54G, ARG54J, ARG67G, ARG67J, ASN172G, ASN172J, ASP12J, ASP50G, ASP50J, GLU139G, GLU139J, GLU38G, GLU38J, GLU4G, GLU4J, GLU64G, GLU64J, GLU86G, GLU86J, GLY10G, GLY10J, GLY141G, GLY141J, GLY421G, GLY421J, GLY58G, GLY58J, GLY65G, GLY65J, HIS69G, HIS69J, HIS70G, HIS70J, ILE140G, ILE140J, ILE142G, ILE142J, ILE48G, ILE48J, LEU143G, LEU143J, LEU36G, LEU36J, LEU40G, LEU40J, LEU414G, LEU414J, LEU422G, LEU422J, LEU47G, LEU47J, LEU55G, LEU55J, LEU6G, LEU6J, LEU89G, LEU89J, LEU9G, LEU9J, LYS11G, LYS11J, LYS41G, LYS41J, LYS44G, LYS44J, MET171G, MET171J, MET93G, MET93J, PHE63G, PHE63J, PRO35G, PRO35J, PRO424G, PRO424J, PRO43G, PRO43J, PRO52G, PRO52J, PRO5G, PRO5J, PRO85G, PRO85J, SER138G, SER138J, SER39G, SER39J, SER59G, SER59J, SER7G, SER7J, SER90G, SER90J, THR133G, THR137G, THR137J, THR168G, THR168J, THR72G, THR88G, THR88J, TYR136G, TYR136J, TYR423G, TYR423J, TYR62G, TYR62J, TYR66G, TYR66J, TYR8G, TYR8J, VAL119G, VAL119J, VAL46G, VAL46J, VAL49G, VAL49J, VAL51G, VAL51J, VAL53G, VAL53J, VAL60G, VAL60J, VAL68G, VAL68J, VAL87G, VAL87J
• G-K: PRO424G, PRO424K, TYR423G, TYR423K
• G-L: ARG131G, ARG131L, ARG134G, ARG134L, ARG135G, ARG135L, ARG54G, ARG54L, ASN172G, ASN172L, ASP167G, ASP167L, GLU130G, GLU130L, GLU139G, GLU139L, GLY127G, GLY127L, GLY141G, GLY141L, GLY174G, GLY174L, ILE142G, ILE142L, MET171G, MET171L, SER138G, SER138L, VAL173G, VAL173L
• H-I: ALA163H, ALA187H, ALA377I, ALA416I, ALA418I, ALA73I, ARG131H, ARG134H, ARG135H, ARG148I, ARG160H, ARG175H, ARG378H, ARG378I, ARG381I, ARG412I, ARG417I, ARG420I, ARG45I, ARG74I, ASN172H, ASN366H, ASN366I, ASN385I, ASP147I, ASP167H, ASP364H, ASP364I, GLN363H, GLN363I, GLU130H, GLU159H, GLU161H, GLU372H, GLU373H, GLU374H, GLU374I, GLU415I, GLY107I, GLY145I, GLY174H, GLY189H, GLY421I, GLY75I, ILE186H, ILE375I, LEU108I, LEU188H, LEU192H, LEU379I, LEU419I, LEU422I, LYS184H, LYS44I, MET162H, MET165H, MET166H, MET171H, PHE359I, PHE365H, PHE365I, PHE369H, PRO109I, PRO146I, PRO178H, PRO185H, PRO424I, PRO76I, SER138H, SER170H, SER367H, THR137H, THR168H, THR176H, THR355I, THR371H, THR411I, THR72I, TRP164H, TRP361I, TRP370H, TRP370I, TYR110I, TYR169H, TYR358I, TYR368H, TYR368I, TYR423I, VAL173H, VAL177H, VAL362H, VAL362I, VAL382I, VAL413I
• H-J: PRO424H, PRO424J, TYR423H, TYR423J
• H-K: ARG131H, ARG131K, ARG134H, ARG134K, ARG135H, ARG135K, ARG54H, ARG54K, ASN172H, ASN172K, ASP167H, ASP167K, ASP56K, GLU130H, GLU130K, GLU139H, GLU139K, GLY127H, GLY127K, GLY174H, GLY174K, ILE142H, ILE142K, MET171H, MET171K, PRO52H, SER125K, SER138H, SER138K, THR168K, VAL173H, VAL173K
• H-L: ALA37H, ALA37L, ALA61H, ALA61L, ARG118H, ARG118L, ARG131H, ARG131L, ARG134H, ARG134L, ARG135H, ARG135L, ARG148H, ARG148L, ARG417H, ARG417L, ARG420H, ARG420L, ARG42H, ARG42L, ARG45H, ARG45L, ARG54H, ARG54L, ARG67H, ARG67L, ASN172H, ASN172L, ASP12H, ASP50H, ASP50L, GLU139H, GLU139L, GLU38H, GLU38L, GLU4H, GLU4L, GLU64H, GLU64L, GLU86H, GLU86L, GLY10H, GLY10L, GLY141H, GLY141L, GLY421H, GLY421L, GLY58H, GLY58L, GLY65H, GLY65L, HIS69H, HIS69L, HIS70H, HIS70L, ILE140H, ILE140L, ILE142H, ILE142L, ILE48H, ILE48L, LEU132L, LEU143H, LEU143L, LEU36H, LEU36L, LEU40H, LEU40L, LEU414H, LEU414L, LEU422H, LEU422L, LEU47H, LEU47L, LEU55H, LEU55L, LEU6H, LEU6L, LEU89H, LEU89L, LEU9H, LEU9L, LYS11H, LYS11L, LYS41H, LYS41L, LYS44H, LYS44L, MET171H, MET171L, MET93H, MET93L, PHE63H, PHE63L, PRO35H, PRO35L, PRO424H, PRO424L, PRO43H, PRO43L, PRO52H, PRO52L, PRO5H, PRO5L, PRO85H, PRO85L, SER138H, SER138L, SER39H, SER39L, SER59H, SER59L, SER7H, SER7L, SER90H, SER90L, THR137H, THR137L, THR168H, THR168L, THR72H, THR72L, THR88H, THR88L, TYR136H, TYR136L, TYR423H, TYR423L, TYR62H, TYR62L, TYR66H, TYR66L, TYR8H, TYR8L, VAL46H, VAL46L, VAL49H, VAL49L, VAL51H, VAL51L, VAL53H, VAL53L, VAL60H, VAL60L, VAL68H, VAL68L, VAL87H, VAL87L
• I-J: ARG131I, ARG131J, ARG134I, ARG134J, ARG135I, ARG135J, ARG54I, ARG54J, ASN172I, ASN172J, ASP167I, ASP167J, GLU130I, GLU130J, GLU139I, GLU139J, GLY127I, GLY127J, GLY174I, GLY174J, ILE142I, ILE142J, MET171I, MET171J, SER138I, SER138J, VAL173I, VAL173J
• I-K: ALA37I, ALA37K, ALA61I, ALA61K, ARG118I, ARG118K, ARG131I, ARG131K, ARG134I, ARG134K, ARG135I, ARG135K, ARG148I, ARG148K, ARG417I, ARG417K, ARG420I, ARG420K, ARG42I, ARG42K, ARG45I, ARG45K, ARG54I, ARG54K, ARG67I, ARG67K, ASN172I, ASN172K, ASP50I, ASP50K, GLU139I, GLU139K, GLU38I, GLU38K, GLU4I, GLU4K, GLU64I, GLU64K, GLU86I, GLU86K, GLY10K, GLY141I, GLY141K, GLY421I, GLY421K, GLY58I, GLY58K, GLY65I, GLY65K, HIS69I, HIS69K, HIS70I, HIS70K, ILE140I, ILE140K, ILE142I, ILE142K, ILE48I, ILE48K, LEU143I, LEU143K, LEU36I, LEU36K, LEU40I, LEU40K, LEU414I, LEU414K, LEU422I, LEU422K, LEU47I, LEU47K, LEU55I, LEU55K, LEU6I, LEU6K, LEU89I, LEU89K, LEU9I, LEU9K, LYS11I, LYS11K, LYS41I, LYS41K, LYS44I, LYS44K, MET171I, MET171K, MET93I, MET93K, PHE63I, PHE63K, PRO35I, PRO35K, PRO424I, PRO424K, PRO43I, PRO43K, PRO52I, PRO52K, PRO5I, PRO5K, PRO85I, PRO85K, SER138I, SER138K, SER39I, SER39K, SER59I, SER59K, SER7I, SER7K, SER90I, SER90K, THR137I, THR137K, THR168I, THR168K, THR72I, THR72K, THR88I, THR88K, TYR136I, TYR136K, TYR423I, TYR423K, TYR62I, TYR62K, TYR66I, TYR66K, TYR8I, TYR8K, VAL119I, VAL46I, VAL46K, VAL49I, VAL49K, VAL51I, VAL51K, VAL53I, VAL53K, VAL60I, VAL60K, VAL68I, VAL68K, VAL87I, VAL87K
• I-L: PRO424I, PRO424L, TYR423I, TYR423L
• J-K: ALA163J, ALA187J, ALA377K, ALA416K, ALA418K, ALA73K, ALA77K, ARG131J, ARG134J, ARG135J, ARG148K, ARG160J, ARG175J, ARG378J, ARG378K, ARG381K, ARG412K, ARG417K, ARG420K, ARG45K, ARG74K, ASN172J, ASN366J, ASN366K, ASN385K, ASP147K, ASP149K, ASP167J, ASP364J, ASP364K, GLN363J, GLN363K, GLU130J, GLU159J, GLU161J, GLU372J, GLU374J, GLU374K, GLU415K, GLY107K, GLY111K, GLY145K, GLY174J, GLY189J, GLY421K, GLY75K, ILE150K, ILE186J, LEU108K, LEU188J, LEU192J, LEU379K, LEU419K, LEU422K, LYS184J, LYS44K, MET162J, MET165J, MET166J, MET171J, PHE359K, PHE365J, PHE365K, PHE369J, PRO109K, PRO146K, PRO178J, PRO185J, PRO424K, PRO76K, SER138J, SER170J, SER367J, THR137J, THR168J, THR176J, THR355K, THR371J, THR411K, THR72K, TRP164J, TRP361K, TRP370J, TRP370K, TYR110K, TYR169J, TYR358K, TYR368J, TYR368K, TYR423K, VAL173J, VAL177J, VAL362J, VAL362K, VAL382K, VAL413K
• J-L: ALA163L, ALA187L, ALA377J, ALA416J, ALA418J, ALA73J, ALA77J, ARG131L, ARG134L, ARG135L, ARG148J, ARG160L, ARG175J, ARG175L, ARG378J, ARG378L, ARG381J, ARG412J, ARG417J, ARG420J, ARG45J, ARG74J, ASN172L, ASN366J, ASN366L, ASN385J, ASP147J, ASP149J, ASP167L, ASP364J, ASP364L, GLN363J, GLN363L, GLU130L, GLU159L, GLU161L, GLU372L, GLU374J, GLU374L, GLU415J, GLY107J, GLY111J, GLY145J, GLY174L, GLY189L, GLY190L, GLY421J, GLY75J, ILE186L, ILE375J, LEU108J, LEU144J, LEU188L, LEU192L, LEU379J, LEU419J, LEU422J, LYS184L, LYS44J, MET162L, MET165L, MET166L, MET171L, PHE359J, PHE365J, PHE365L, PHE369L, PRO109J, PRO146J, PRO178L, PRO185L, PRO424J, PRO76J, SER138L, SER170L, SER367L, THR137L, THR168L, THR176L, THR355J, THR371L, THR411J, THR72J, TRP164L, TRP361J, TRP370J, TRP370L, TYR110J, TYR169L, TYR358J, TYR368J, TYR368L, TYR423J, VAL173L, VAL177L, VAL362J, VAL362L, VAL382J, VAL413J
• K-L: ALA163K, ALA187K, ALA377L, ALA416L, ALA418L, ALA73L, ALA77L, ARG131K, ARG134K, ARG135K, ARG148L, ARG160K, ARG175K, ARG378K, ARG378L, ARG381L, ARG412L, ARG417L, ARG420L, ARG45L, ARG74L, ASN172K, ASN366K, ASN366L, ASN385L, ASP147L, ASP149L, ASP167K, ASP364K, ASP364L, GLN363K, GLN363L, GLU130K, GLU159K, GLU161K, GLU372K, GLU373K, GLU374K, GLU374L, GLU415L, GLY107L, GLY111L, GLY145L, GLY174K, GLY189K, GLY421L, GLY75L, ILE142L, ILE150L, ILE186K, ILE375L, LEU108L, LEU143L, LEU144L, LEU188K, LEU192K, LEU379L, LEU419L, LEU422L, LYS184K, LYS44L, MET162K, MET165K, MET166K, MET171K, PHE359L, PHE365K, PHE365L, PHE369K, PRO109L, PRO146L, PRO178K, PRO185K, PRO424L, PRO76L, SER138K, SER170K, SER367K, SER367L, THR137K, THR168K, THR176K, THR355L, THR371K, THR411L, THR72L, TRP164K, TRP361L, TRP370K, TRP370L, TYR110L, TYR169K, TYR358L, TYR368K, TYR368L, TYR423L, VAL173K, VAL177K, VAL362K, VAL362L, VAL382L, VAL413L