3ALQ

crystal structure of tnf-tnfr2 complex

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: C-T
  • Int. Res.: 73
  • Norm. En. per Res.: -4.383
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-39.6876	-34.9377	-278.237	-352.8624	108	12	9	11940	3	9	6
A-C	-60.099	-30.2721	-270.157	-360.5281	107	10	10	11734	3	9	6
A-R	-47.5896	-108.8045	-161.393	-317.7871	75	13	2	6561	4	19	9
A-T	0.0	0.0	-128.947	-128.947	80	6	5	5473	0	5	8
A-V	0.0	0.0	-15.3195	-15.3195	26	0	0	853	0	1	1
B-C	-68.7731	-33.5224	-282.704	-384.9995	107	13	9	11903	3	9	6
B-R	-7.2472	0.0	-134.403	-141.6502	83	5	4	5538	0	6	10
B-S	-49.6841	-112.5123	-157.261	-319.4574	73	12	2	6388	6	19	9
B-U	0.0	0.0	-14.1222	-14.1222	26	1	0	814	0	1	1
C-S	0.0	0.0	-125.614	-125.614	78	4	4	5189	0	6	9
C-T	-53.8093	-101.3526	-164.798	-319.9599	73	17	2	6439	5	19	9
C-W	0.0	0.0	-12.6776	-12.6776	26	0	0	784	0	1	1
D-E	-52.3472	-33.142	-272.334	-357.8233	110	20	12	11852	4	9	6
D-F	-57.7455	-32.5509	-283.602	-373.8984	110	14	10	12057	4	9	7
D-S	0.0	0.0	-11.8164	-11.8164	26	0	0	745	0	1	1
D-U	-30.4419	-96.5576	-167.029	-294.0286	76	9	2	6511	6	19	8
D-W	0.0	0.0	-124.971	-124.971	80	7	5	5399	0	6	9
E-F	-40.6022	-30.9137	-284.515	-356.0309	110	16	11	12067	3	9	6
E-R	0.0	0.0	-10.7604	-10.7604	25	3	0	854	0	1	1
E-U	-6.1671	0.0	-124.752	-130.9191	80	3	4	5258	0	6	8
E-V	-43.2316	-103.1489	-157.395	-303.7755	72	13	2	6350	6	20	8
F-T	0.0	0.0	-18.3016	-18.3016	28	1	0	971	0	1	1
F-V	0.0	0.0	-134.5	-134.5	82	13	6	5656	0	5	10
F-W	-45.6516	-101.7067	-145.649	-293.0073	69	11	2	6162	4	20	9
R-V	-61.3796	-16.0987	-143.777	-221.2553	83	15	0	5805	0	8	14
S-U	-59.8064	-25.1752	-134.804	-219.7856	84	14	0	5539	0	12	14
T-W	-52.7479	-19.7396	-142.483	-214.9706	80	14	0	5618	0	8	13

Interface residues

• A-B: ALA111A, ALA145A, ALA14A, ALA156A, ALA156B, ALA33A, ALA35A, ALA38A, ALA84B, ALA96B, ARG82B, ARG98A, ARG98B, ASN112A, ASN34A, ASN39A, ASN92B, ASP10A, ASP143A, CYS101A, CYS101B, CYS69A, GLN102A, GLN102B, GLN125B, GLN149A, GLN61A, GLN67A, GLU116A, GLU116B, GLU146A, GLU53B, GLY121A, GLY121B, GLY122B, GLY148A, GLY153A, GLY54B, GLY66A, GLY68A, HIS15A, HIS73B, HIS78B, ILE118A, ILE118B, ILE154A, ILE155A, ILE155B, ILE58A, ILE58B, ILE80B, ILE97B, LEU120A, LEU120B, LEU126B, LEU132B, LEU157A, LEU157B, LEU36A, LEU55B, LEU57A, LEU57B, LEU63A, LEU75B, LEU76B, LEU93B, LEU94B, MET11A, MET11B, PHE124B, PHE152A, PHE64A, PRO100A, PRO100B, PRO113A, PRO117A, PRO117B, PRO12A, PRO70A, SER147A, SER60A, SER60B, SER65A, SER71B, SER81B, SER95B, SER99A, SER99B, SER9A, THR72B, THR77B, THR79B, TRP114A, TYR115A, TYR119A, TYR119B, TYR151A, TYR56B, TYR59A, TYR59B, TYR87B, VAL123B, VAL13A, VAL150A, VAL17A, VAL62A, VAL74B, VAL91B
• A-C: ALA111C, ALA145C, ALA14C, ALA156A, ALA156C, ALA33C, ALA35C, ALA38C, ALA84A, ALA96A, ARG82A, ARG98A, ARG98C, ASN112C, ASN34C, ASN39C, ASN92A, ASP10C, ASP143C, CYS101A, CYS101C, CYS69C, GLN102A, GLN102C, GLN125A, GLN149C, GLN61C, GLN67C, GLU116A, GLU116C, GLU146C, GLU53A, GLY121A, GLY121C, GLY122A, GLY148C, GLY153C, GLY54A, GLY66C, GLY68C, HIS15C, HIS73A, HIS78A, ILE118A, ILE118C, ILE154C, ILE155A, ILE155C, ILE58A, ILE58C, ILE80A, ILE97A, LEU120A, LEU120C, LEU126A, LEU132A, LEU157A, LEU157C, LEU36C, LEU55A, LEU57A, LEU57C, LEU63C, LEU75A, LEU76A, LEU93A, LEU94A, MET11A, MET11C, PHE124A, PHE152C, PHE64C, PRO100A, PRO100C, PRO113C, PRO117A, PRO117C, PRO12C, SER147C, SER60A, SER60C, SER65C, SER71A, SER81A, SER95A, SER99A, SER99C, SER9C, THR72A, THR77A, THR79A, TRP114C, TYR115C, TYR119A, TYR119C, TYR151C, TYR56A, TYR59A, TYR59C, TYR87A, VAL123A, VAL13C, VAL150C, VAL17C, VAL62C, VAL74A, VAL91A
• A-R: ALA105R, ALA111A, ALA116R, ALA145A, ALA18A, ALA22A, ALA33A, ALA35A, ALA41R, ARG113R, ARG31A, ARG32A, ARG77R, ARG94R, ASN112A, ASN19A, ASN30A, ASN34A, ASN93R, ASP143A, ASP54R, ASP58R, ASP81R, CYS112R, CYS115R, CYS71R, CYS74R, CYS78R, CYS88R, CYS96R, GLN109R, GLN149A, GLN21A, GLN67A, GLN82R, GLU110R, GLU146A, GLU23A, GLU57R, GLU70R, GLY148A, GLY66A, GLY75R, HIS40R, LEU106R, LEU114R, LEU142A, LEU29A, LEU36A, LEU63A, LEU72R, LYS108R, LYS42R, PHE144A, PHE64A, PRO113A, PRO117R, PRO20A, PRO69R, SER107R, SER147A, SER59R, SER65A, SER73R, SER76R, SER79R, SER80R, THR60R, THR62R, TRP102R, TRP114A, TYR115A, TYR61R, VAL17A, VAL68R
• A-T: ALA105T, ALA116T, ALA41T, ALA84A, ALA96A, ARG113T, ARG119T, ARG138A, ARG82A, ARG98A, ASN137A, ASN66T, ASN92A, ASN93T, ASP130A, ASP136T, CYS104T, CYS115T, CYS35T, CYS71T, GLN109T, GLN125A, GLN26T, GLN39T, GLN63T, GLN88A, GLN92T, GLU127A, GLU135A, GLU53A, GLU70T, GLU91T, GLY129A, GLY38T, HIS40T, HIS73A, ILE83A, ILE97A, LEU106T, LEU114T, LEU64T, LEU72T, LEU75A, LEU76A, LEU93A, LYS108T, LYS34T, PHE44T, PRO117T, PRO128A, PRO37T, PRO51A, PRO69T, PRO90A, SER107T, SER36T, SER52A, SER71A, SER73T, SER81A, SER86A, SER95A, SER99A, THR27T, THR62T, THR72A, THR77A, THR79A, THR89A, TRP65T, TRP67T, TYR103T, TYR23T, TYR24T, TYR61T, TYR87A, VAL68T, VAL74A, VAL85A, VAL91A
• A-V: ALA111A, ALA167V, ALA176V, ALA22A, ARG122V, ASN112A, ASN171V, ASP140A, ASP175V, CYS69A, GLN21A, GLN25A, GLN67A, GLU23A, GLY170V, GLY24A, GLY68A, ILE168V, MET174V, PRO123V, PRO169V, PRO20A, PRO70A, SER173V, THR151V, VAL177V
• B-C: ALA111B, ALA145B, ALA14B, ALA156B, ALA33B, ALA35B, ALA38B, ALA84C, ALA96C, ARG82C, ARG98B, ARG98C, ASN112B, ASN34B, ASN39B, ASN92C, ASP10B, ASP130C, ASP143B, CYS101B, CYS101C, CYS69B, GLN102B, GLN102C, GLN125C, GLN149B, GLN61B, GLN67B, GLU116B, GLU116C, GLU146B, GLU53C, GLY121B, GLY121C, GLY122C, GLY148B, GLY153B, GLY54C, GLY66B, GLY68B, HIS15B, HIS73C, HIS78C, ILE118B, ILE118C, ILE154B, ILE155B, ILE155C, ILE58C, ILE80C, ILE97C, LEU120B, LEU120C, LEU126C, LEU157B, LEU157C, LEU36B, LEU55C, LEU57B, LEU57C, LEU63B, LEU75C, LEU76C, LEU93C, LEU94C, MET11B, MET11C, PHE124C, PHE152B, PHE64B, PRO100B, PRO100C, PRO113B, PRO117B, PRO117C, PRO12B, PRO90C, SER147B, SER60B, SER65B, SER71C, SER81C, SER95C, SER99B, SER99C, SER9B, THR72C, THR77C, THR79C, THR89C, TRP114B, TYR115B, TYR115C, TYR119B, TYR119C, TYR151B, TYR56C, TYR59B, TYR59C, TYR87C, VAL123C, VAL13B, VAL150B, VAL17B, VAL62B, VAL74C, VAL91C
• B-R: ALA105R, ALA116R, ALA41R, ALA84B, ALA96B, ARG113R, ARG119R, ARG122R, ARG138B, ARG82B, ARG98B, ASN137B, ASN66R, ASN92B, ASN93R, ASP130B, ASP136R, ASP25R, CYS104R, CYS115R, CYS35R, CYS71R, GLN109R, GLN125B, GLN26R, GLN39R, GLN63R, GLN88B, GLN92R, GLU110R, GLU127B, GLU135B, GLU53B, GLU70R, GLU91R, GLY129B, GLY38R, HIS40R, HIS73B, HIS78B, ILE83B, ILE97B, LEU106R, LEU114R, LEU64R, LEU72R, LEU75B, LEU76B, LYS108R, LYS34R, PHE44R, PRO117R, PRO128B, PRO37R, PRO51B, PRO69R, PRO90B, SER107R, SER36R, SER52B, SER71B, SER73R, SER81B, SER86B, SER95B, SER99B, THR27R, THR62R, THR72B, THR77B, THR79B, THR89B, TRP65R, TRP67R, TYR103R, TYR23R, TYR24R, TYR61R, TYR87B, VAL68R, VAL74B, VAL85B, VAL91B
• B-S: ALA105S, ALA111B, ALA116S, ALA145B, ALA18B, ALA22B, ALA33B, ALA35B, ALA41S, ARG113S, ARG31B, ARG32B, ARG77S, ARG94S, ASN112B, ASN19B, ASN30B, ASN34B, ASN93S, ASP143B, ASP58S, ASP81S, CYS112S, CYS115S, CYS71S, CYS74S, CYS78S, CYS88S, CYS96S, GLN109S, GLN149B, GLN21B, GLN67B, GLN82S, GLU110S, GLU146B, GLU23B, GLU57S, GLU70S, GLY148B, GLY66B, GLY75S, HIS40S, LEU106S, LEU114S, LEU142B, LEU29B, LEU36B, LEU63B, LEU72S, LYS108S, LYS42S, PHE144B, PRO113B, PRO117S, PRO20B, PRO69S, SER107S, SER147B, SER59S, SER65B, SER73S, SER76S, SER79S, SER80S, THR60S, THR62S, TRP102S, TRP114B, TYR115B, TYR61S, VAL17B, VAL68S
• B-U: ALA111B, ALA167U, ALA176U, ALA22B, ARG122U, ASN112B, ASN171U, ASN19B, ASP140B, ASP175U, CYS69B, GLN21B, GLN25B, GLN67B, GLU23B, GLY170U, GLY24B, GLY68B, ILE168U, MET174U, PRO123U, PRO169U, PRO20B, PRO70B, THR151U, VAL177U
• C-S: ALA105S, ALA116S, ALA41S, ALA84C, ALA96C, ARG113S, ARG119S, ARG138C, ARG82C, ARG98C, ASN137C, ASN66S, ASN92C, ASN93S, ASP130C, ASP136S, ASP25S, CYS35S, CYS71S, GLN109S, GLN125C, GLN26S, GLN39S, GLN63S, GLN88C, GLN92S, GLU110S, GLU127C, GLU53C, GLU70S, GLU91S, GLY38S, HIS40S, HIS73C, ILE83C, ILE97C, LEU106S, LEU114S, LEU64S, LEU72S, LEU75C, LEU76C, LEU93C, LYS108S, LYS34S, PHE44S, PRO117S, PRO128C, PRO37S, PRO51C, PRO69S, PRO90C, SER107S, SER36S, SER52C, SER71C, SER73S, SER81C, SER86C, SER95C, SER99C, THR27S, THR62S, THR72C, THR77C, THR79C, THR89C, TRP65S, TRP67S, TYR103S, TYR23S, TYR24S, TYR61S, TYR87C, VAL68S, VAL74C, VAL85C, VAL91C
• C-T: ALA105T, ALA111C, ALA116T, ALA145C, ALA18C, ALA22C, ALA33C, ALA35C, ARG113T, ARG31C, ARG32C, ARG77T, ARG94T, ASN112C, ASN19C, ASN30C, ASN34C, ASN93T, ASP143C, ASP58T, ASP81T, CYS112T, CYS115T, CYS71T, CYS74T, CYS78T, CYS88T, CYS96T, GLN109T, GLN149C, GLN21C, GLN61C, GLN67C, GLN82T, GLU110T, GLU146C, GLU23C, GLU57T, GLU70T, GLY148C, GLY66C, GLY75T, HIS40T, LEU106T, LEU114T, LEU29C, LEU36C, LEU63C, LEU72T, LYS108T, LYS42T, PHE144C, PHE64C, PRO113C, PRO117T, PRO20C, PRO69T, SER107T, SER147C, SER59T, SER65C, SER73T, SER76T, SER79T, SER80T, THR60T, THR62T, TRP102T, TRP114C, TYR115C, TYR61T, VAL17C, VAL68T
• C-W: ALA111C, ALA167W, ALA176W, ALA22C, ARG122W, ASN112C, ASN171W, ASN19C, ASP140C, ASP175W, CYS69C, GLN21C, GLN25C, GLN67C, GLU23C, GLY170W, GLY24C, GLY68C, ILE168W, MET174W, PRO123W, PRO169W, PRO20C, PRO70C, THR151W, VAL177W
• D-E: ALA111D, ALA145D, ALA14D, ALA156D, ALA156E, ALA33D, ALA35D, ALA38D, ALA84E, ALA96E, ARG82E, ARG98D, ARG98E, ASN112D, ASN34D, ASN39D, ASN92E, ASP10D, ASP143D, CYS101D, CYS101E, CYS69D, GLN102D, GLN102E, GLN125E, GLN149D, GLN61D, GLN67D, GLU116D, GLU116E, GLU146D, GLU53E, GLY121D, GLY121E, GLY122E, GLY148D, GLY153D, GLY54E, GLY66D, GLY68D, HIS15D, HIS73E, HIS78E, ILE118D, ILE118E, ILE154D, ILE155D, ILE155E, ILE58D, ILE58E, ILE80E, ILE83E, ILE97E, LEU120D, LEU120E, LEU126E, LEU132E, LEU157D, LEU157E, LEU36D, LEU37D, LEU55E, LEU57D, LEU57E, LEU63D, LEU75E, LEU76E, LEU93E, LEU94E, MET11D, MET11E, PHE124E, PHE152D, PHE64D, PRO100D, PRO100E, PRO113D, PRO117D, PRO117E, PRO12D, SER147D, SER60D, SER60E, SER65D, SER71E, SER81E, SER86E, SER95E, SER99D, SER99E, SER9D, THR72E, THR77E, THR79E, TRP114D, TYR115D, TYR119D, TYR119E, TYR151D, TYR56E, TYR59D, TYR59E, TYR87E, VAL123E, VAL13D, VAL150D, VAL17D, VAL62D, VAL74E, VAL91E
• D-F: ALA111F, ALA145F, ALA14F, ALA156D, ALA156F, ALA33F, ALA35F, ALA38F, ALA84D, ALA96D, ARG82D, ARG98D, ARG98F, ASN112F, ASN34F, ASN39F, ASN92D, ASP10F, ASP143F, CYS101D, CYS101F, CYS69F, GLN102D, GLN102F, GLN125D, GLN149F, GLN61F, GLN67F, GLU116D, GLU116F, GLU146F, GLU53D, GLY121D, GLY121F, GLY122D, GLY148F, GLY153F, GLY54D, GLY66F, GLY68F, HIS15F, HIS73D, HIS78D, ILE118D, ILE118F, ILE154F, ILE155D, ILE155F, ILE58D, ILE58F, ILE80D, ILE97D, LEU120D, LEU120F, LEU126D, LEU132D, LEU157D, LEU157F, LEU36F, LEU37F, LEU55D, LEU57D, LEU57F, LEU63F, LEU75D, LEU76D, LEU93D, LEU94D, MET11D, MET11F, PHE124D, PHE152F, PHE64F, PRO100D, PRO100F, PRO113F, PRO117D, PRO117F, PRO12F, PRO90D, SER147F, SER60D, SER60F, SER65F, SER71D, SER81D, SER86D, SER95D, SER99D, SER99F, SER9F, THR72D, THR77D, THR79D, TRP114F, TYR115F, TYR119D, TYR119F, TYR151F, TYR56D, TYR59D, TYR59F, TYR87D, VAL123D, VAL13F, VAL150F, VAL17F, VAL62F, VAL74D, VAL91D
• D-S: ALA111D, ALA167S, ALA176S, ALA22D, ARG122S, ASN112D, ASN171S, ASN19D, ASP175S, CYS69D, GLN21D, GLN25D, GLN67D, GLU23D, GLY170S, GLY24D, GLY68D, ILE168S, MET174S, PRO123S, PRO169S, PRO20D, PRO70D, SER173S, THR151S, VAL177S
• D-U: ALA105U, ALA111D, ALA116U, ALA145D, ALA18D, ALA22D, ALA33D, ALA35D, ARG113U, ARG31D, ARG32D, ARG77U, ARG94U, ASN112D, ASN19D, ASN30D, ASN34D, ASN93U, ASP143D, ASP58U, ASP81U, CYS112U, CYS115U, CYS56U, CYS71U, CYS74U, CYS78U, CYS88U, GLN109U, GLN149D, GLN21D, GLN25D, GLN67D, GLN82U, GLU110U, GLU116D, GLU146D, GLU23D, GLU57U, GLU70U, GLY148D, GLY24D, GLY66D, GLY75U, HIS40U, LEU106U, LEU114U, LEU142D, LEU29D, LEU36D, LEU63D, LEU72U, LYS108U, PHE144D, PHE64D, PRO113D, PRO117U, PRO20D, PRO69U, SER107U, SER147D, SER59U, SER65D, SER73U, SER76U, SER79U, SER80U, THR60U, THR62U, TRP102U, TRP114D, TYR115D, TYR61U, VAL150D, VAL17D, VAL68U
• D-W: ALA105W, ALA116W, ALA41W, ALA84D, ALA96D, ARG113W, ARG119W, ARG138D, ARG82D, ARG98D, ASN137D, ASN66W, ASN92D, ASN93W, ASP130D, ASP136W, CYS104W, CYS115W, CYS71W, GLN109W, GLN125D, GLN26W, GLN39W, GLN63W, GLN88D, GLN92W, GLU110W, GLU127D, GLU135D, GLU53D, GLU70W, GLU91W, GLY129D, GLY38W, HIS40W, HIS73D, HIS78D, ILE83D, ILE97D, LEU106W, LEU114W, LEU64W, LEU72W, LEU75D, LEU76D, LEU93D, LYS108W, LYS34W, PHE44W, PRO117W, PRO128D, PRO37W, PRO51D, PRO69W, PRO90D, SER107W, SER52D, SER71D, SER73W, SER81D, SER86D, SER95D, SER99D, THR27W, THR62W, THR72D, THR77D, THR79D, THR89D, TRP65W, TRP67W, TYR103W, TYR23W, TYR24W, TYR61W, TYR87D, VAL68W, VAL74D, VAL85D, VAL91D
• E-F: ALA111E, ALA145E, ALA14E, ALA156E, ALA156F, ALA33E, ALA35E, ALA38E, ALA84F, ALA96F, ARG82F, ARG98E, ARG98F, ASN112E, ASN34E, ASN39E, ASN92F, ASP10E, ASP130F, ASP143E, CYS101E, CYS101F, CYS69E, GLN102E, GLN102F, GLN125F, GLN149E, GLN61E, GLN67E, GLU116E, GLU116F, GLU146E, GLU53F, GLY121E, GLY121F, GLY122F, GLY148E, GLY153E, GLY54F, GLY66E, GLY68E, HIS15E, HIS73F, HIS78F, ILE118E, ILE118F, ILE154E, ILE155E, ILE155F, ILE58E, ILE58F, ILE80F, ILE97F, LEU120E, LEU120F, LEU126F, LEU157E, LEU157F, LEU36E, LEU37E, LEU55F, LEU57E, LEU57F, LEU63E, LEU75F, LEU76F, LEU93F, LEU94F, MET11E, MET11F, PHE124F, PHE152E, PHE64E, PRO100E, PRO100F, PRO113E, PRO117E, PRO117F, PRO12E, SER147E, SER60E, SER60F, SER65E, SER71F, SER81F, SER86F, SER95F, SER99E, SER99F, SER9E, THR72F, THR77F, THR79F, TRP114E, TYR115E, TYR115F, TYR119E, TYR119F, TYR151E, TYR56F, TYR59E, TYR59F, TYR87F, VAL123F, VAL13E, VAL150E, VAL17E, VAL62E, VAL74F, VAL91F
• E-R: ALA111E, ALA167R, ALA176R, ALA22E, ARG122R, ASN112E, ASN171R, ASN19E, ASP140E, ASP175R, CYS69E, GLN21E, GLN25E, GLN67E, GLU23E, GLY170R, GLY24E, GLY68E, ILE168R, MET174R, PRO123R, PRO169R, PRO20E, THR151R, VAL177R
• E-U: ALA105U, ALA116U, ALA41U, ALA84E, ALA96E, ARG113U, ARG119U, ARG122U, ARG138E, ARG82E, ARG98E, ASN137E, ASN66U, ASN92E, ASN93U, ASP130E, ASP136U, CYS115U, CYS35U, CYS71U, GLN109U, GLN125E, GLN26U, GLN39U, GLN63U, GLN88E, GLN92U, GLU110U, GLU127E, GLU135E, GLU53E, GLU70U, GLU91U, GLY129E, GLY38U, HIS40U, HIS73E, ILE83E, ILE97E, LEU106U, LEU114U, LEU64U, LEU72U, LEU75E, LEU76E, LEU93E, LYS108U, LYS34U, PHE44U, PRO117U, PRO128E, PRO37U, PRO51E, PRO69U, PRO90E, SER107U, SER52E, SER71E, SER73U, SER81E, SER86E, SER95E, SER99E, THR27U, THR62U, THR72E, THR77E, THR79E, THR89E, TRP65U, TRP67U, TYR103U, TYR23U, TYR24U, TYR61U, TYR87E, VAL68U, VAL74E, VAL85E, VAL91E
• E-V: ALA105V, ALA111E, ALA116V, ALA145E, ALA18E, ALA22E, ALA33E, ALA35E, ARG113V, ARG31E, ARG32E, ARG77V, ARG94V, ASN112E, ASN19E, ASN30E, ASN34E, ASN93V, ASP143E, ASP58V, ASP81V, CYS112V, CYS115V, CYS56V, CYS71V, CYS74V, CYS78V, CYS88V, GLN109V, GLN149E, GLN21E, GLN67E, GLN82V, GLU110V, GLU146E, GLU23E, GLU57V, GLU70V, GLY148E, GLY66E, GLY75V, HIS40V, LEU106V, LEU114V, LEU142E, LEU29E, LEU36E, LEU63E, LEU72V, LYS108V, PHE144E, PHE64E, PRO113E, PRO117V, PRO20E, PRO69V, SER107V, SER147E, SER59V, SER65E, SER73V, SER76V, SER79V, SER80V, THR60V, THR62V, TRP102V, TRP114E, TYR115E, TYR61V, VAL17E, VAL68V
• F-T: ALA111F, ALA167T, ALA176T, ALA22F, ARG122T, ASN112F, ASN149T, ASN171T, ASN19F, ASP140F, ASP175T, CYS69F, GLN21F, GLN25F, GLN67F, GLU23F, GLY124T, GLY170T, GLY24F, GLY68F, ILE168T, MET174T, PRO123T, PRO169T, PRO70F, SER173T, THR151T, VAL177T
• F-V: ALA105V, ALA116V, ALA41V, ALA84F, ALA96F, ARG113V, ARG119V, ARG138F, ARG82F, ARG98F, ASN137F, ASN66V, ASN92F, ASN93V, ASP130F, ASP136V, ASP25V, CYS104V, CYS115V, CYS35V, CYS71V, GLN109V, GLN125F, GLN26V, GLN39V, GLN63V, GLN88F, GLN92V, GLU110V, GLU127F, GLU135F, GLU53F, GLU70V, GLU91V, GLY129F, GLY38V, HIS40V, HIS73F, ILE83F, ILE97F, LEU106V, LEU114V, LEU64V, LEU72V, LEU75F, LEU76F, LEU93F, LYS108V, LYS34V, PHE44V, PRO117V, PRO128F, PRO37V, PRO51F, PRO69V, PRO70F, PRO90F, SER107V, SER52F, SER71F, SER73V, SER81F, SER86F, SER95F, SER99F, THR27V, THR62V, THR72F, THR77F, THR79F, THR89F, TRP65V, TRP67V, TYR103V, TYR23V, TYR24V, TYR61V, TYR87F, VAL68V, VAL74F, VAL85F, VAL91F
• F-W: ALA105W, ALA111F, ALA116W, ALA145F, ALA18F, ALA22F, ALA33F, ALA35F, ARG113W, ARG31F, ARG32F, ARG77W, ARG94W, ASN112F, ASN19F, ASN30F, ASN34F, ASN93W, ASP143F, ASP58W, ASP81W, CYS112W, CYS115W, CYS56W, CYS71W, CYS74W, CYS78W, CYS88W, GLN109W, GLN149F, GLN21F, GLN67F, GLN82W, GLU110W, GLU146F, GLU23F, GLU57W, GLU70W, GLY148F, GLY66F, GLY75W, HIS40W, LEU106W, LEU114W, LEU142F, LEU29F, LEU36F, LEU63F, LEU72W, LYS108W, PHE144F, PRO113F, PRO20F, PRO69W, SER107W, SER147F, SER59W, SER65F, SER73W, SER76W, SER79W, SER80W, THR60W, THR62W, TRP114F, TYR115F, TYR61W, VAL17F, VAL68W
• R-V: ALA167R, ALA167V, ALA176R, ALA176V, ARG122R, ARG122V, ARG158R, ARG158V, ARG77R, ARG77V, ARG94R, ARG94V, ARG99R, ARG99V, ASN149R, ASN149V, ASN171R, ASN171V, ASP155R, ASP155V, ASP175R, ASP175V, ASP81R, ASP81V, CYS121R, CYS121V, CYS178R, CYS178V, CYS78R, CYS78V, GLN161V, GLN82R, GLN82V, GLU84R, GLU84V, GLY124R, GLY124V, GLY170R, GLY170V, HIS160R, HIS160V, ILE168R, ILE168V, LYS120R, LYS120V, MET174R, MET174V, PHE147R, PHE147V, PRO117R, PRO117V, PRO123R, PRO123V, PRO169R, PRO169V, SER148R, SER148V, SER152R, SER152V, SER153R, SER153V, SER173R, SER173V, SER59R, SER59V, SER76R, SER76V, SER79R, SER79V, SER80R, SER80V, THR150R, THR150V, THR151R, THR151V, THR154R, THR154V, TRP102R, TRP102V, VAL177R, VAL177V, VAL83R, VAL83V
• S-U: ALA167S, ALA167U, ALA176S, ALA176U, ARG122S, ARG122U, ARG158S, ARG77S, ARG77U, ARG94S, ARG94U, ARG99S, ARG99U, ASN149S, ASN149U, ASN171S, ASN171U, ASP155S, ASP155U, ASP175S, ASP175U, ASP58U, ASP81S, ASP81U, CYS121S, CYS121U, CYS178S, CYS178U, CYS78S, CYS78U, GLN161S, GLN161U, GLN82S, GLN82U, GLU84S, GLU84U, GLY124S, GLY124U, GLY170S, GLY170U, ILE168S, ILE168U, LEU118S, LYS120S, LYS120U, MET174S, MET174U, PHE147S, PHE147U, PRO117S, PRO117U, PRO123S, PRO123U, PRO169S, PRO169U, SER148S, SER148U, SER152S, SER152U, SER153S, SER153U, SER173S, SER173U, SER59S, SER59U, SER76S, SER76U, SER79S, SER79U, SER80S, SER80U, THR150S, THR150U, THR151S, THR151U, THR154S, THR154U, TRP102S, TRP102U, VAL165S, VAL177S, VAL177U, VAL83S, VAL83U
• T-W: ALA167W, ALA176T, ALA176W, ARG122T, ARG122W, ARG158T, ARG158W, ARG77T, ARG77W, ARG94T, ARG94W, ARG99T, ARG99W, ASN149T, ASN149W, ASN171T, ASN171W, ASP155T, ASP155W, ASP175T, ASP175W, ASP81T, ASP81W, CYS121T, CYS178T, CYS178W, CYS78T, CYS78W, GLN161T, GLN161W, GLN82T, GLN82W, GLU84T, GLU84W, GLY124T, GLY124W, GLY170T, GLY170W, HIS160T, ILE168T, ILE168W, LYS120T, LYS120W, MET174T, MET174W, PHE147T, PHE147W, PRO117T, PRO117W, PRO123T, PRO123W, PRO169T, PRO169W, SER148T, SER148W, SER152T, SER152W, SER153T, SER153W, SER173T, SER173W, SER59T, SER76T, SER76W, SER79T, SER79W, SER80T, SER80W, THR150T, THR150W, THR151T, THR151W, THR154T, THR154W, TRP102T, TRP102W, VAL177T, VAL177W, VAL83T, VAL83W