3AK8

crystal structure of the sep22 dodecamer, a dps-like protein from salmonella enterica subsp. enterica serovar enteritidis

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: D-F
  • Int. Res.: 73
  • Norm. En. per Res.: -5.5986
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-81.6793	-87.0027	-356.556	-525.238	137	19	6	15858	6	28	22
A-E	-41.637	-127.9842	-214.924	-384.5452	74	8	0	7435	8	40	43
A-H	-22.6757	-5.7842	-104.484	-132.9439	40	1	5	4007	0	11	8
A-I	-45.3566	-115.7301	-216.399	-377.4857	73	10	0	7488	8	40	42
A-K	-22.9641	-7.1574	-106.11	-136.2315	41	1	5	4052	0	11	8
B-D	-78.8736	-59.011	-356.355	-494.2396	138	17	5	15846	4	28	22
B-F	-23.5478	-7.9036	-105.383	-136.8344	41	2	5	4039	0	11	8
B-G	-56.6636	-124.1415	-214.539	-395.3441	74	11	0	7417	8	40	42
B-J	-23.2018	-5.5825	-103.808	-132.5923	40	1	5	4008	0	10	8
B-L	-47.3345	-124.4552	-216.271	-388.0607	73	10	0	7407	8	40	43
C-E	-23.5963	-5.4688	-104.384	-133.4492	40	1	5	4019	0	10	8
C-H	-58.2016	-122.4813	-221.373	-402.0559	73	10	0	7499	8	40	43
C-J	-53.8612	-124.3408	-213.252	-391.454	73	12	0	7489	8	41	42
C-L	-24.4485	-5.7172	-106.119	-136.2846	40	1	5	4068	0	10	8
D-F	-52.2448	-139.0859	-217.369	-408.6997	73	11	0	7485	10	41	42
D-G	-28.142	-10.8347	-114.729	-153.7057	41	1	5	4202	0	11	8
D-I	-23.6114	-6.1118	-107.001	-136.7242	41	2	5	4050	0	11	8
D-K	-46.8097	-124.3971	-222.415	-393.6218	73	8	0	7501	8	42	42
E-G	-56.4145	-88.0102	-370.531	-514.9557	137	22	6	16006	6	28	23
E-I	-47.3113	-126.644	-216.921	-390.8763	73	10	0	7483	9	40	42
E-L	-23.2452	-5.2794	-103.165	-131.6897	40	1	5	3973	0	10	8
F-H	-76.293	-66.9093	-359.822	-503.0242	140	15	6	15770	6	29	23
F-J	-22.5706	-7.2797	-105.714	-135.5643	41	1	5	4011	0	10	8
F-K	-39.2696	-123.3918	-215.837	-378.4984	74	10	0	7437	8	40	43
G-I	-22.3728	-5.4806	-106.932	-134.7854	42	1	5	4063	0	10	8
G-L	-42.1052	-126.775	-217.402	-386.2821	73	8	0	7495	8	40	43
H-J	-37.9527	-126.4004	-217.003	-381.3561	73	11	0	7426	8	41	43
H-K	-22.745	-11.1747	-110.605	-144.5247	43	2	5	4150	0	10	8
I-K	-72.865	-60.1893	-360.541	-493.5953	139	17	6	15938	4	28	22
J-L	-70.3695	-72.3827	-366.2	-508.9522	138	11	5	15770	6	28	22

Interface residues

• A-C: ALA50A, ALA50C, ALA81A, ALA81C, ALA84A, ALA84C, ALA91A, ALA91C, ARG124A, ARG124C, ARG55A, ARG55C, ARG70A, ARG70C, ARG83A, ARG83C, ASN113A, ASN13C, ASN34A, ASN34C, ASN53A, ASN53C, ASN99A, ASN99C, ASP110A, ASP110C, ASP42A, ASP42C, ASP67A, ASP67C, ASP75A, ASP75C, ASP78A, ASP78C, GLN39C, GLN49A, GLN49C, GLN86A, GLN86C, GLN96A, GLN96C, GLU82A, GLU82C, GLY88A, GLY88C, GLY89A, GLY89C, GLY93A, GLY93C, HIS112A, HIS112C, HIS117A, HIS117C, HIS51A, HIS51C, HIS63A, HIS63C, ILE111A, ILE111C, ILE38A, ILE38C, ILE41A, ILE41C, ILE46A, ILE46C, ILE98A, ILE98C, LEU104A, LEU104C, LEU109A, LEU109C, LEU14A, LEU14C, LEU15A, LEU15C, LEU43A, LEU43C, LEU45A, LEU45C, LEU73A, LEU73C, LEU77A, LEU77C, LEU87A, LEU87C, LEU92A, LEU92C, LYS101A, LYS101C, LYS105A, LYS105C, LYS48A, LYS48C, MET54A, MET54C, MET80A, MET80C, PHE59A, PHE59C, PRO108A, PRO108C, SER100A, SER100C, SER106A, SER106C, SER44A, SER44C, THR102A, THR102C, THR17A, THR17C, THR47A, THR47C, THR71A, THR71C, THR74A, THR74C, THR79A, THR79C, THR94A, THR94C, THR95A, THR95C, TRP52A, TRP52C, TYR107A, TYR107C, TYR16A, TYR16C, VAL37A, VAL37C, VAL85A, VAL85C, VAL90A, VAL90C, VAL97A, VAL97C
• A-E: ALA122E, ALA126E, ALA129E, ALA135E, ALA139E, ALA145A, ALA145E, ALA150A, ALA150E, ALA151A, ALA151E, ALA81A, ARG124E, ARG133E, ARG153E, ARG18A, ARG83A, ASN130E, ASN19A, ASP123E, ASP131E, ASP141A, ASP143A, ASP146A, ASP146E, ASP154E, ASP156E, ASP20A, ASP75A, ASP78A, GLN115E, GLN86A, GLU120E, GLU138E, GLU142A, GLU163E, GLU82A, GLY137E, GLY88A, HIS76A, ILE136E, ILE147A, ILE162E, ILE166E, LEU118E, LEU121E, LEU155E, LEU159E, LEU15A, LEU87A, LYS119E, LYS134E, LYS157E, LYS26A, MET80A, PHE148A, PHE148E, PHE158E, PHE161E, SER152E, SER164E, SER22A, THR144A, THR149A, THR149E, THR17A, THR79A, TRP160E, TYR125E, TYR16A, VAL127E, VAL132E, VAL21A, VAL85A
• A-H: ALA57A, ALA57H, ALA61A, ALA61H, ARG55A, ASN113A, ASN165H, ASN53A, ASN58A, ASN58H, GLN115H, GLU163H, GLU167A, GLU167H, GLU64A, GLU64H, GLY56A, HIS51A, HIS63A, HIS63H, ILE162H, ILE166H, ILE60A, ILE60H, LEU118H, LEU66H, LYS157H, MET54A, MET65H, PHE158H, PHE161H, PHE59A, PHE69H, SER164H, TRP160H, TRP52A, VAL114A, VAL114H, VAL62A, VAL62H
• A-I: ALA122A, ALA126A, ALA129A, ALA135A, ALA145A, ALA145I, ALA150A, ALA150I, ALA151A, ALA151I, ALA81I, ARG124A, ARG133A, ARG153A, ARG18I, ARG83I, ASN130A, ASN19I, ASP123A, ASP131A, ASP141I, ASP143I, ASP146A, ASP146I, ASP154A, ASP156A, ASP20I, ASP75I, ASP78I, GLN115A, GLN86I, GLU120A, GLU138A, GLU142I, GLU163A, GLU82I, GLY137A, GLY88I, HIS76I, ILE136A, ILE147I, ILE162A, ILE166A, LEU118A, LEU121A, LEU155A, LEU159A, LEU15I, LEU87I, LYS119A, LYS134A, LYS157A, LYS26I, MET80I, PHE148A, PHE148I, PHE158A, PHE161A, SER152A, SER164A, SER22I, THR144I, THR149A, THR149I, THR17I, THR79I, TRP160A, TYR125A, TYR16I, VAL127A, VAL132A, VAL21I, VAL85I
• A-K: ALA57A, ALA57K, ALA61A, ALA61K, ARG55K, ASN113K, ASN165A, ASN53K, ASN58A, ASN58K, ASP67K, GLN115A, GLU163A, GLU167A, GLU167K, GLU64A, GLU64K, GLY56K, HIS51K, HIS63A, HIS63K, ILE162A, ILE166A, ILE60A, ILE60K, LEU118A, LEU66A, LYS157A, MET54K, MET65A, PHE158A, PHE161A, PHE59K, PHE69A, SER164A, TRP160A, TRP52K, VAL114A, VAL114K, VAL62A, VAL62K
• B-D: ALA50B, ALA50D, ALA81B, ALA81D, ALA84B, ALA84D, ALA91B, ALA91D, ARG124B, ARG124D, ARG18B, ARG55B, ARG55D, ARG70B, ARG70D, ARG83B, ARG83D, ASN13B, ASN13D, ASN34B, ASN34D, ASN53B, ASN53D, ASN99B, ASN99D, ASP110B, ASP110D, ASP42B, ASP42D, ASP67B, ASP67D, ASP75B, ASP75D, ASP78B, ASP78D, GLN39B, GLN49B, GLN49D, GLN86B, GLN86D, GLN96B, GLN96D, GLU82B, GLU82D, GLY88B, GLY88D, GLY89B, GLY89D, GLY93B, GLY93D, HIS112B, HIS112D, HIS117B, HIS117D, HIS51B, HIS51D, HIS63B, HIS63D, ILE111B, ILE111D, ILE38B, ILE38D, ILE41B, ILE41D, ILE46B, ILE46D, ILE98B, ILE98D, LEU104B, LEU104D, LEU109B, LEU109D, LEU14B, LEU14D, LEU15B, LEU15D, LEU43B, LEU43D, LEU45B, LEU45D, LEU73B, LEU73D, LEU77B, LEU77D, LEU87B, LEU87D, LEU92B, LEU92D, LYS101B, LYS101D, LYS105B, LYS105D, LYS48B, LYS48D, MET54B, MET54D, MET80B, MET80D, PHE59B, PHE59D, PRO108B, PRO108D, SER100B, SER100D, SER106B, SER106D, SER44B, SER44D, THR102B, THR102D, THR17B, THR17D, THR47B, THR47D, THR71B, THR71D, THR74B, THR74D, THR79B, THR79D, THR94B, THR94D, THR95B, THR95D, TRP52B, TRP52D, TYR107B, TYR107D, TYR16B, TYR16D, VAL37B, VAL37D, VAL85B, VAL85D, VAL90B, VAL90D, VAL97B, VAL97D
• B-F: ALA57B, ALA57F, ALA61B, ALA61F, ARG55B, ASN113B, ASN165F, ASN53B, ASN58B, ASN58F, ASP67B, GLN115F, GLU163F, GLU167B, GLU167F, GLU64B, GLU64F, GLY56B, HIS51B, HIS63B, HIS63F, ILE162F, ILE166F, ILE60B, ILE60F, LEU118F, LEU66F, LYS157F, MET54B, MET65F, PHE158F, PHE161F, PHE59B, PHE69F, SER164F, TRP160F, TRP52B, VAL114B, VAL114F, VAL62B, VAL62F
• B-G: ALA122G, ALA126G, ALA129G, ALA135G, ALA139G, ALA145B, ALA145G, ALA150B, ALA150G, ALA151B, ALA151G, ALA81B, ARG124G, ARG133G, ARG153G, ARG18B, ARG83B, ASN130G, ASN19B, ASP123G, ASP131G, ASP141B, ASP143B, ASP146B, ASP146G, ASP154G, ASP156G, ASP20B, ASP75B, ASP78B, GLN115G, GLN86B, GLU120G, GLU138G, GLU142B, GLU163G, GLU82B, GLY137G, GLY88B, HIS76B, ILE136G, ILE147B, ILE162G, ILE166G, LEU118G, LEU121G, LEU155G, LEU159G, LEU15B, LEU87B, LYS119G, LYS134G, LYS157G, LYS26B, MET80B, PHE148B, PHE148G, PHE158G, PHE161G, SER152G, SER164G, SER22B, THR144B, THR149B, THR149G, THR17B, THR79B, TRP160G, TYR125G, TYR16B, VAL127G, VAL132G, VAL21B, VAL85B
• B-J: ALA57B, ALA57J, ALA61B, ALA61J, ARG55J, ASN113J, ASN165B, ASN53J, ASN58B, ASN58J, GLN115B, GLU163B, GLU167B, GLU167J, GLU64B, GLU64J, GLY56J, HIS51J, HIS63B, HIS63J, ILE162B, ILE166B, ILE60B, ILE60J, LEU118B, LEU66B, LYS157B, MET54J, MET65B, PHE158B, PHE161B, PHE59J, PHE69B, SER164B, TRP160B, TRP52J, VAL114B, VAL114J, VAL62B, VAL62J
• B-L: ALA122B, ALA126B, ALA129B, ALA135B, ALA145B, ALA145L, ALA150B, ALA150L, ALA151B, ALA151L, ALA81L, ARG124B, ARG133B, ARG153B, ARG18L, ARG83L, ASN130B, ASN19L, ASP123B, ASP131B, ASP141L, ASP143L, ASP146B, ASP146L, ASP154B, ASP156B, ASP20L, ASP75L, ASP78L, GLN115B, GLN86L, GLU120B, GLU138B, GLU142L, GLU163B, GLU82L, GLY137B, GLY88L, HIS76L, ILE136B, ILE147L, ILE162B, ILE166B, LEU118B, LEU121B, LEU155B, LEU159B, LEU15L, LEU87L, LYS119B, LYS134B, LYS157B, LYS26L, MET80L, PHE148B, PHE148L, PHE158B, PHE161B, SER152B, SER164B, SER22L, THR144L, THR149B, THR149L, THR17L, THR79L, TRP160B, TYR125B, TYR16L, VAL127B, VAL132B, VAL21L, VAL85L
• C-E: ALA57C, ALA57E, ALA61C, ALA61E, ARG55C, ASN113C, ASN165E, ASN53C, ASN58C, ASN58E, GLN115E, GLU163E, GLU167C, GLU167E, GLU64C, GLU64E, GLY56C, HIS51C, HIS63C, HIS63E, ILE162E, ILE166E, ILE60C, ILE60E, LEU118E, LEU66E, LYS157E, MET54C, MET65E, PHE158E, PHE161E, PHE59C, PHE69E, SER164E, TRP160E, TRP52C, VAL114C, VAL114E, VAL62C, VAL62E
• C-H: ALA122H, ALA126H, ALA129H, ALA135H, ALA145C, ALA145H, ALA150C, ALA150H, ALA151C, ALA151H, ALA81C, ARG124H, ARG133H, ARG153H, ARG18C, ARG83C, ASN130H, ASN19C, ASP123H, ASP131H, ASP141C, ASP143C, ASP146C, ASP146H, ASP154H, ASP156H, ASP20C, ASP75C, ASP78C, GLN115H, GLN86C, GLU120H, GLU138H, GLU142C, GLU163H, GLU82C, GLY137H, GLY88C, HIS76C, ILE136H, ILE147C, ILE162H, ILE166H, LEU118H, LEU121H, LEU155H, LEU159H, LEU15C, LEU87C, LYS119H, LYS134H, LYS157H, LYS26C, MET80C, PHE148C, PHE148H, PHE158H, PHE161H, SER152H, SER164H, SER22C, THR144C, THR149C, THR149H, THR17C, THR79C, TRP160H, TYR125H, TYR16C, VAL127H, VAL132H, VAL21C, VAL85C
• C-J: ALA122C, ALA126C, ALA129C, ALA135C, ALA145C, ALA145J, ALA150C, ALA150J, ALA151C, ALA151J, ALA81J, ARG124C, ARG133C, ARG153C, ARG18J, ARG83J, ASN130C, ASN19J, ASP123C, ASP131C, ASP141J, ASP143J, ASP146C, ASP146J, ASP154C, ASP156C, ASP20J, ASP75J, ASP78J, GLN115C, GLN86J, GLU120C, GLU138C, GLU142J, GLU163C, GLU82J, GLY137C, GLY88J, HIS76J, ILE136C, ILE147J, ILE162C, ILE166C, LEU118C, LEU121C, LEU155C, LEU159C, LEU15J, LEU87J, LYS119C, LYS134C, LYS157C, LYS26J, MET80J, PHE148C, PHE148J, PHE158C, PHE161C, SER152C, SER164C, SER22J, THR144J, THR149C, THR149J, THR17J, THR79J, TRP160C, TYR125C, TYR16J, VAL127C, VAL132C, VAL21J, VAL85J
• C-L: ALA57C, ALA57L, ALA61C, ALA61L, ARG55L, ASN113L, ASN165C, ASN53L, ASN58C, ASN58L, GLN115C, GLU163C, GLU167C, GLU167L, GLU64C, GLU64L, GLY56L, HIS51L, HIS63C, HIS63L, ILE162C, ILE166C, ILE60C, ILE60L, LEU118C, LEU66C, LYS157C, MET54L, MET65C, PHE158C, PHE161C, PHE59L, PHE69C, SER164C, TRP160C, TRP52L, VAL114C, VAL114L, VAL62C, VAL62L
• D-F: ALA122F, ALA126F, ALA129F, ALA135F, ALA145D, ALA145F, ALA150D, ALA150F, ALA151D, ALA151F, ALA81D, ARG124F, ARG133F, ARG153F, ARG18D, ARG83D, ASN130F, ASN19D, ASP123F, ASP131F, ASP141D, ASP143D, ASP146D, ASP146F, ASP154F, ASP156F, ASP20D, ASP75D, ASP78D, GLN115F, GLN86D, GLU120F, GLU138F, GLU142D, GLU163F, GLU82D, GLY137F, GLY88D, HIS76D, ILE136F, ILE147D, ILE162F, ILE166F, LEU118F, LEU121F, LEU155F, LEU159F, LEU15D, LEU87D, LYS119F, LYS134F, LYS157F, LYS26D, MET80D, PHE148D, PHE148F, PHE158F, PHE161F, SER152F, SER164F, SER22D, THR144D, THR149D, THR149F, THR17D, THR79D, TRP160F, TYR125F, TYR16D, VAL127F, VAL132F, VAL21D, VAL85D
• D-G: ALA57D, ALA57G, ALA61D, ALA61G, ARG55D, ASN113D, ASN165G, ASN53D, ASN58D, ASN58G, GLN115G, GLU163G, GLU167D, GLU167G, GLU64D, GLU64G, GLY56D, HIS51D, HIS63D, HIS63G, ILE162G, ILE166G, ILE60D, ILE60G, LEU118G, LEU159G, LEU66G, LYS157G, MET54D, MET65G, PHE158G, PHE161G, PHE59D, PHE69G, SER164G, TRP160G, TRP52D, VAL114D, VAL114G, VAL62D, VAL62G
• D-I: ALA57D, ALA57I, ALA61D, ALA61I, ARG55I, ASN113I, ASN165D, ASN53I, ASN58D, ASN58I, GLN115D, GLU163D, GLU167D, GLU167I, GLU64D, GLU64I, GLY56I, HIS51I, HIS63D, HIS63I, ILE162D, ILE166D, ILE60D, ILE60I, LEU118D, LEU159D, LEU66D, LYS157D, MET54I, MET65D, PHE158D, PHE161D, PHE59I, PHE69D, SER164D, TRP160D, TRP52I, VAL114D, VAL114I, VAL62D, VAL62I
• D-K: ALA122D, ALA126D, ALA129D, ALA135D, ALA145D, ALA145K, ALA150D, ALA150K, ALA151D, ALA151K, ALA81K, ARG124D, ARG133D, ARG153D, ARG18K, ARG83K, ASN130D, ASN19K, ASP123D, ASP131D, ASP141K, ASP143K, ASP146D, ASP146K, ASP154D, ASP156D, ASP20K, ASP75K, ASP78K, GLN115D, GLN86K, GLU120D, GLU138D, GLU142K, GLU163D, GLU82K, GLY137D, GLY88K, HIS76K, ILE136D, ILE147K, ILE162D, ILE166D, LEU118D, LEU121D, LEU155D, LEU159D, LEU15K, LEU87K, LYS119D, LYS134D, LYS157D, LYS26K, MET80K, PHE148D, PHE148K, PHE158D, PHE161D, SER152D, SER164D, SER22K, THR144K, THR149D, THR149K, THR17K, THR79K, TRP160D, TYR125D, TYR16K, VAL127D, VAL132D, VAL21K, VAL85K
• E-G: ALA50E, ALA50G, ALA81E, ALA81G, ALA84E, ALA84G, ALA91E, ALA91G, ARG124E, ARG124G, ARG55E, ARG55G, ARG70E, ARG70G, ARG83E, ARG83G, ASN113E, ASN13E, ASN13G, ASN34E, ASN34G, ASN53E, ASN53G, ASN99E, ASN99G, ASP110E, ASP110G, ASP42E, ASP42G, ASP67E, ASP67G, ASP75E, ASP75G, ASP78E, ASP78G, GLN39E, GLN49E, GLN49G, GLN86E, GLN86G, GLN96E, GLN96G, GLU82E, GLU82G, GLY88E, GLY88G, GLY89E, GLY89G, GLY93E, GLY93G, HIS112E, HIS112G, HIS117E, HIS117G, HIS51E, HIS51G, HIS63E, HIS63G, ILE111E, ILE111G, ILE38E, ILE38G, ILE41E, ILE41G, ILE46E, ILE46G, ILE98E, ILE98G, LEU104E, LEU104G, LEU109E, LEU109G, LEU14E, LEU14G, LEU15E, LEU15G, LEU43E, LEU43G, LEU45E, LEU45G, LEU73E, LEU73G, LEU77E, LEU77G, LEU87G, LEU92E, LEU92G, LYS101E, LYS101G, LYS105E, LYS105G, LYS48E, LYS48G, MET54E, MET54G, MET80E, MET80G, PHE59E, PHE59G, PRO108E, PRO108G, SER100E, SER100G, SER106E, SER106G, SER44E, SER44G, THR102E, THR102G, THR17E, THR17G, THR47E, THR47G, THR71E, THR71G, THR74E, THR74G, THR79E, THR79G, THR94E, THR94G, THR95E, THR95G, TRP52E, TRP52G, TYR107E, TYR107G, TYR16E, TYR16G, VAL37E, VAL37G, VAL85E, VAL85G, VAL90E, VAL90G, VAL97E, VAL97G
• E-I: ALA122I, ALA126I, ALA129I, ALA135I, ALA145E, ALA145I, ALA150E, ALA150I, ALA151E, ALA151I, ALA81E, ARG124I, ARG133I, ARG153I, ARG18E, ARG83E, ASN130I, ASN19E, ASP123I, ASP131I, ASP141E, ASP143E, ASP146E, ASP146I, ASP154I, ASP156I, ASP20E, ASP75E, ASP78E, GLN115I, GLN86E, GLU120I, GLU138I, GLU142E, GLU163I, GLU82E, GLY137I, GLY88E, HIS76E, ILE136I, ILE147E, ILE162I, ILE166I, LEU118I, LEU121I, LEU155I, LEU159I, LEU15E, LEU87E, LYS119I, LYS134I, LYS157I, LYS26E, MET80E, PHE148E, PHE148I, PHE158I, PHE161I, SER152I, SER164I, SER22E, THR144E, THR149E, THR149I, THR17E, THR79E, TRP160I, TYR125I, TYR16E, VAL127I, VAL132I, VAL21E, VAL85E
• E-L: ALA57E, ALA57L, ALA61E, ALA61L, ARG55E, ASN113E, ASN165L, ASN53E, ASN58E, ASN58L, GLN115L, GLU163L, GLU167E, GLU167L, GLU64E, GLU64L, GLY56E, HIS51E, HIS63E, HIS63L, ILE162L, ILE166L, ILE60E, ILE60L, LEU118L, LEU66L, LYS157L, MET54E, MET65L, PHE158L, PHE161L, PHE59E, PHE69L, SER164L, TRP160L, TRP52E, VAL114E, VAL114L, VAL62E, VAL62L
• F-H: ALA11F, ALA50F, ALA50H, ALA81F, ALA81H, ALA84F, ALA84H, ALA91F, ALA91H, ARG124F, ARG124H, ARG18F, ARG55F, ARG55H, ARG70F, ARG70H, ARG83F, ARG83H, ASN113H, ASN13F, ASN13H, ASN34F, ASN34H, ASN53F, ASN53H, ASN99F, ASN99H, ASP110F, ASP110H, ASP42F, ASP42H, ASP67F, ASP67H, ASP75F, ASP75H, ASP78F, ASP78H, GLN39F, GLN49F, GLN49H, GLN86F, GLN86H, GLN96F, GLN96H, GLU82F, GLU82H, GLY88F, GLY88H, GLY89F, GLY89H, GLY93F, GLY93H, HIS112F, HIS112H, HIS117F, HIS117H, HIS51F, HIS51H, HIS63F, HIS63H, ILE111F, ILE111H, ILE38F, ILE38H, ILE41F, ILE41H, ILE46F, ILE46H, ILE98F, ILE98H, LEU104F, LEU104H, LEU109F, LEU109H, LEU14F, LEU14H, LEU15F, LEU15H, LEU43F, LEU43H, LEU45F, LEU45H, LEU73F, LEU73H, LEU77F, LEU77H, LEU87F, LEU92F, LEU92H, LYS101F, LYS101H, LYS105F, LYS105H, LYS10F, LYS48F, LYS48H, MET54F, MET54H, MET80F, MET80H, PHE59F, PHE59H, PRO108F, PRO108H, SER100F, SER100H, SER106F, SER106H, SER44F, SER44H, THR102F, THR102H, THR17F, THR17H, THR47F, THR47H, THR71F, THR71H, THR74F, THR74H, THR79F, THR79H, THR94F, THR94H, THR95F, THR95H, TRP52F, TRP52H, TYR107F, TYR107H, TYR16F, TYR16H, VAL37F, VAL37H, VAL85F, VAL85H, VAL90F, VAL90H, VAL97F, VAL97H
• F-J: ALA57F, ALA57J, ALA61F, ALA61J, ARG55F, ASN113F, ASN165J, ASN53F, ASN58F, ASN58J, ASP67F, GLN115J, GLU163J, GLU167F, GLU167J, GLU64F, GLU64J, GLY56F, HIS51F, HIS63F, HIS63J, ILE162J, ILE166J, ILE60F, ILE60J, LEU118J, LEU66J, LYS157J, MET54F, MET65J, PHE158J, PHE161J, PHE59F, PHE69J, SER164J, TRP160J, TRP52F, VAL114F, VAL114J, VAL62F, VAL62J
• F-K: ALA122K, ALA126K, ALA129K, ALA135K, ALA139K, ALA145F, ALA145K, ALA150F, ALA150K, ALA151F, ALA151K, ALA81F, ARG124K, ARG133K, ARG153K, ARG18F, ARG83F, ASN130K, ASN19F, ASP123K, ASP131K, ASP141F, ASP143F, ASP146F, ASP146K, ASP154K, ASP156K, ASP20F, ASP75F, ASP78F, GLN115K, GLN86F, GLU120K, GLU138K, GLU142F, GLU163K, GLU82F, GLY137K, GLY88F, HIS76F, ILE136K, ILE147F, ILE162K, ILE166K, LEU118K, LEU121K, LEU155K, LEU159K, LEU15F, LEU87F, LYS119K, LYS134K, LYS157K, LYS26F, MET80F, PHE148F, PHE148K, PHE158K, PHE161K, SER152K, SER164K, SER22F, THR144F, THR149F, THR149K, THR17F, THR79F, TRP160K, TYR125K, TYR16F, VAL127K, VAL132K, VAL21F, VAL85F
• G-I: ALA57G, ALA57I, ALA61G, ALA61I, ARG55G, ASN113G, ASN165I, ASN53G, ASN58G, ASN58I, ASP67G, GLN115I, GLU163I, GLU167G, GLU167I, GLU64G, GLU64I, GLY56G, HIS112G, HIS51G, HIS63G, HIS63I, ILE162I, ILE166I, ILE60G, ILE60I, LEU118I, LEU66I, LYS157I, MET54G, MET65I, PHE158I, PHE161I, PHE59G, PHE69I, SER164I, TRP160I, TRP52G, VAL114G, VAL114I, VAL62G, VAL62I
• G-L: ALA122L, ALA126L, ALA129L, ALA135L, ALA145G, ALA145L, ALA150G, ALA150L, ALA151G, ALA151L, ALA81G, ARG124L, ARG133L, ARG153L, ARG18G, ARG83G, ASN130L, ASN19G, ASP123L, ASP131L, ASP141G, ASP143G, ASP146G, ASP146L, ASP154L, ASP156L, ASP20G, ASP75G, ASP78G, GLN115L, GLN86G, GLU120L, GLU138L, GLU142G, GLU163L, GLU82G, GLY137L, GLY88G, HIS76G, ILE136L, ILE147G, ILE162L, ILE166L, LEU118L, LEU121L, LEU155L, LEU159L, LEU15G, LEU87G, LYS119L, LYS134L, LYS157L, LYS26G, MET80G, PHE148G, PHE148L, PHE158L, PHE161L, SER152L, SER164L, SER22G, THR144G, THR149G, THR149L, THR17G, THR79G, TRP160L, TYR125L, TYR16G, VAL127L, VAL132L, VAL21G, VAL85G
• H-J: ALA122J, ALA126J, ALA129J, ALA135J, ALA145H, ALA145J, ALA150H, ALA150J, ALA151H, ALA151J, ALA81H, ARG124J, ARG133J, ARG153J, ARG18H, ARG83H, ASN130J, ASN19H, ASP123J, ASP131J, ASP141H, ASP143H, ASP146H, ASP146J, ASP154J, ASP156J, ASP20H, ASP75H, ASP78H, GLN115J, GLN86H, GLU120J, GLU138J, GLU142H, GLU163J, GLU82H, GLY137J, GLY88H, HIS76H, ILE136J, ILE147H, ILE162J, ILE166J, LEU118J, LEU121J, LEU155J, LEU159J, LEU15H, LEU87H, LYS119J, LYS134J, LYS157J, LYS26H, MET80H, PHE148H, PHE148J, PHE158J, PHE161J, SER152J, SER164J, SER22H, THR144H, THR149H, THR149J, THR17H, THR79H, TRP160J, TYR125J, TYR16H, VAL127J, VAL132J, VAL21H, VAL85H
• H-K: ALA57H, ALA57K, ALA61H, ALA61K, ARG55H, ASN113H, ASN165K, ASN53H, ASN58H, ASN58K, ASP67H, GLN115K, GLU163K, GLU167H, GLU167K, GLU64H, GLU64K, GLY56H, HIS112H, HIS51H, HIS63H, HIS63K, ILE162K, ILE166K, ILE60H, ILE60K, LEU118K, LEU159K, LEU66K, LYS157K, MET54H, MET65K, PHE158K, PHE161K, PHE59H, PHE69K, SER164K, TRP160K, TRP52H, VAL114H, VAL114K, VAL62H, VAL62K
• I-K: ALA50I, ALA50K, ALA81I, ALA81K, ALA84I, ALA84K, ALA91I, ALA91K, ARG124I, ARG124K, ARG55I, ARG55K, ARG70I, ARG70K, ARG83I, ARG83K, ASN113I, ASN113K, ASN13I, ASN13K, ASN34I, ASN34K, ASN53I, ASN53K, ASN99I, ASN99K, ASP110I, ASP110K, ASP42I, ASP42K, ASP67I, ASP67K, ASP75I, ASP75K, ASP78I, ASP78K, GLN39K, GLN49I, GLN49K, GLN86I, GLN86K, GLN96I, GLN96K, GLU82I, GLU82K, GLY88I, GLY88K, GLY89I, GLY89K, GLY93I, GLY93K, HIS112I, HIS112K, HIS117I, HIS117K, HIS51I, HIS51K, HIS63I, HIS63K, ILE111I, ILE111K, ILE38I, ILE38K, ILE41I, ILE41K, ILE46I, ILE46K, ILE98I, ILE98K, LEU104I, LEU104K, LEU109I, LEU109K, LEU14I, LEU14K, LEU15I, LEU15K, LEU43I, LEU43K, LEU45I, LEU45K, LEU73I, LEU73K, LEU77I, LEU77K, LEU87I, LEU87K, LEU92I, LEU92K, LYS101I, LYS101K, LYS105I, LYS105K, LYS48I, LYS48K, MET54I, MET54K, MET80I, MET80K, PHE59I, PHE59K, PRO108I, PRO108K, SER100I, SER100K, SER106I, SER106K, SER44I, SER44K, THR102I, THR102K, THR17I, THR17K, THR47I, THR47K, THR71I, THR71K, THR74I, THR74K, THR79I, THR79K, THR94I, THR94K, THR95I, THR95K, TRP52I, TRP52K, TYR107I, TYR107K, TYR16I, TYR16K, VAL37I, VAL37K, VAL85I, VAL85K, VAL90I, VAL90K, VAL97I, VAL97K
• J-L: ALA50J, ALA50L, ALA81J, ALA81L, ALA84J, ALA84L, ALA91J, ALA91L, ARG124J, ARG124L, ARG55J, ARG55L, ARG70J, ARG70L, ARG83J, ARG83L, ASN113J, ASN113L, ASN13J, ASN13L, ASN34J, ASN34L, ASN53J, ASN53L, ASN99J, ASN99L, ASP110J, ASP110L, ASP42J, ASP42L, ASP67J, ASP67L, ASP75J, ASP75L, ASP78J, ASP78L, GLN49J, GLN49L, GLN86J, GLN86L, GLN96J, GLN96L, GLU82J, GLU82L, GLY88J, GLY88L, GLY89J, GLY89L, GLY93J, GLY93L, HIS112J, HIS112L, HIS117J, HIS117L, HIS51J, HIS51L, HIS63J, HIS63L, ILE111J, ILE111L, ILE38J, ILE38L, ILE41J, ILE41L, ILE46J, ILE46L, ILE98J, ILE98L, LEU104J, LEU104L, LEU109J, LEU109L, LEU14J, LEU14L, LEU15J, LEU15L, LEU43J, LEU43L, LEU45J, LEU45L, LEU73J, LEU73L, LEU77J, LEU77L, LEU87J, LEU87L, LEU92J, LEU92L, LYS101J, LYS101L, LYS105J, LYS105L, LYS48J, LYS48L, MET54J, MET54L, MET80J, MET80L, PHE59J, PHE59L, PRO108J, PRO108L, SER100J, SER100L, SER106J, SER106L, SER44J, SER44L, THR102J, THR102L, THR17J, THR17L, THR47J, THR47L, THR71J, THR71L, THR74J, THR74L, THR79J, THR79L, THR94J, THR94L, THR95J, THR95L, TRP52J, TRP52L, TYR107J, TYR107L, TYR16J, TYR16L, VAL37J, VAL37L, VAL85J, VAL85L, VAL90J, VAL90L, VAL97J, VAL97L