3AB4

crystal structure of feedback inhibition resistant mutant of aspartate kinase from corynebacterium glutamicum in complex with lysine and threonine

• Total interactions analyzed: 120
• Total true interactions: 36
• Strongest Interaction:
  • Chains: M-N
  • Int. Res.: 226
  • Norm. En. per Res.: -4.208
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-72.3925	-80.306	-625.813	-778.5115	215	33	19	26815	5	63	71
A-C	-4.8396	49.3655	-332.026	-287.5001	124	17	27	14822	1	18	23
A-E	-38.3803	-29.5244	-76.3314	-144.2361	54	4	1	2987	1	26	24
A-F	0.0	0.0	-6.7435	-6.7435	18	0	0	431	0	7	7
A-M	-26.2785	-31.9905	-75.3055	-133.5746	54	7	1	3225	1	28	24
A-O	-8.9326	-6.2991	-81.2294	-96.4611	72	2	0	4191	0	29	18
B-M	-11.0415	-17.2972	-19.3998	-47.7385	23	4	0	1026	2	7	6
C-D	-75.9099	-82.8518	-627.7	-786.4617	213	40	22	26601	7	61	64
C-E	-5.7594	-3.3245	-104.678	-113.762	73	3	0	5211	2	28	17
C-F	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	2	0
C-G	-33.1809	-34.3376	-83.667	-151.1855	54	3	1	3391	2	24	24
C-O	0.0	-23.3522	-59.4502	-82.8024	47	1	0	2752	2	20	24
C-P	-20.1697	-6.2931	-96.4975	-122.9603	42	5	1	3587	1	15	15
D-G	0.0	0.0	-10.4247	-10.4247	18	1	0	472	0	7	4
E-F	-74.0229	-109.7257	-648.842	-832.5906	206	40	21	27057	8	60	59
E-G	-4.9638	24.9482	-342.297	-322.3126	125	16	29	15336	2	17	23
E-I	-27.3393	-32.68	-79.7122	-139.7315	54	5	1	3292	1	26	25
E-J	0.0	0.0	-4.5468	-4.5468	18	0	0	359	0	5	3
G-H	-71.7159	-93.0828	-590.547	-755.3456	199	32	23	25301	7	55	56
G-I	0.0	-3.7747	-75.2509	-79.0256	70	2	0	4220	0	31	17
G-K	-4.4629	-22.0729	-45.7394	-72.2753	41	5	0	2170	3	20	21
H-I	0.0	0.0	-0.0033	-0.0033	3	0	0	2	0	2	0
H-K	0.0	14.5346	-54.8672	-40.3326	35	3	1	2341	1	12	14
I-J	-67.5528	-63.9547	-532.905	-664.4124	193	32	22	23873	7	48	44
I-K	-9.9836	54.0351	-338.653	-294.6015	126	23	28	15058	0	17	23
I-M	-18.7544	-19.6272	-84.2099	-122.5915	57	7	1	3689	1	26	25
I-N	0.0	-8.2925	-30.626	-38.9185	30	1	1	1778	0	10	12
K-L	-100.5164	-87.3089	-732.437	-920.2623	235	43	26	31204	6	68	71
K-M	-4.138	18.432	-141.889	-127.5951	77	6	0	6459	2	30	21
K-N	0.0	0.0	-0.012	-0.012	3	0	0	15	0	2	1
K-O	-30.4738	-18.7269	-86.7378	-135.9385	56	3	1	3514	1	25	25
L-M	0.0	0.0	-0.1184	-0.1184	5	0	0	53	0	1	1
L-O	-2.215	-6.1712	-39.7494	-48.1356	30	4	2	2194	2	11	13
M-N	-147.6154	-79.4862	-723.907	-951.0086	226	42	26	30242	8	61	61
M-O	-2.4117	85.3015	-367.224	-284.3342	126	19	29	15602	0	17	25
O-P	-57.4785	-37.1945	-510.996	-605.669	192	43	17	22507	3	53	56

Interface residues

• A-B: ALA103B, ALA10B, ALA113B, ALA118B, ALA164B, ALA205A, ALA206A, ALA222A, ALA279A, ALA280A, ALA285A, ALA287A, ALA289A, ALA30B, ALA31B, ALA362A, ALA367A, ALA36B, ALA38B, ALA40B, ARG120B, ARG135B, ARG141B, ARG215A, ARG221A, ARG284A, ARG35B, ARG369A, ARG384A, ARG390A, ASN123B, ASN125B, ASN292A, ASN299A, ASN372A, ASN374A, ASN43B, ASN50B, ASP121B, ASP144B, ASP162B, ASP25B, ASP274A, ASP288A, ASP294A, ASP309A, ASP318A, ASP341A, ASP370A, ASP39B, ASP45B, ASP60B, ASP92B, CYS314A, GLN155B, GLN298A, GLN49B, GLU114B, GLU117B, GLU127B, GLU133B, GLU15B, GLU161B, GLU163B, GLU199A, GLU200A, GLU203A, GLU218A, GLU246A, GLU264A, GLU278A, GLU290A, GLU29B, GLU363A, GLU366A, GLU376A, GLU382A, GLU41B, GLY102B, GLY104B, GLY110B, GLY208A, GLY22B, GLY271A, GLY277A, GLY28B, GLY353A, GLY359A, GLY8B, HIS108B, HIS357A, ILE126B, ILE129B, ILE134B, ILE136B, ILE140B, ILE23B, ILE272A, ILE291A, ILE293A, ILE310A, ILE375A, ILE378A, ILE383A, ILE385A, ILE389A, ILE42B, ILE44B, ILE61B, LEU119B, LEU128B, LEU139B, LEU202A, LEU204A, LEU214A, LEU21B, LEU270A, LEU286A, LEU297A, LEU339A, LEU368A, LEU377A, LEU37B, LEU388A, LEU48B, LEU6B, LEU90B, LYS106B, LYS17B, LYS210A, LYS266A, LYS26B, LYS275A, LYS281A, LYS32B, LYS346A, LYS355A, LYS97B, MET105B, MET116B, MET201A, MET245A, MET295A, MET354A, MET365A, MET46B, PHE115B, PHE198A, PHE223A, PHE283A, PHE301A, PHE312A, PHE34B, PHE364A, PHE52B, PHE63B, PRO109B, PRO276A, PRO27B, PRO315A, PRO358A, SER107B, SER130B, SER132B, SER137B, SER209A, SER216A, SER24B, SER273A, SER302A, SER356A, SER379A, SER381A, SER386A, SER53B, THR112B, THR131B, THR156A, THR19B, THR268A, THR308A, THR311A, THR313A, THR361A, THR380A, THR59B, THR62B, THR64B, THR7B, THR87B, TYR219A, VAL101B, VAL111B, VAL122B, VAL124B, VAL138B, VAL18B, VAL207A, VAL20B, VAL213A, VAL217A, VAL267A, VAL269A, VAL282A, VAL296A, VAL300A, VAL33B, VAL360A, VAL371A, VAL373A, VAL387A, VAL47B, VAL51B, VAL5B, VAL95B
• A-C: ALA134C, ALA16A, ALA16C, ALA23A, ALA23C, ALA54A, ALA54C, ALA55A, ALA55C, ALA56A, ALA56C, ALA63A, ALA63C, ALA72A, ALA72C, ALA79A, ALA79C, ALA82A, ALA82C, ALA84A, ALA84C, ALA90C, ALA92A, ALA92C, ARG18A, ARG18C, ARG20A, ARG20C, ARG64A, ARG64C, ARG75A, ARG75C, ASN21A, ASN21C, ASN58A, ASN58C, ASN78A, ASN78C, ASP67A, ASP67C, GLN93A, GLN93C, GLU14A, GLU14C, GLU17A, GLU17C, GLU49A, GLU49C, GLU52A, GLU52C, GLU65A, GLU65C, GLU74A, GLU74C, GLU86A, GLU86C, GLU91C, GLY73A, GLY73C, GLY89A, GLY89C, ILE132A, ILE132C, ILE19A, ILE19C, ILE76A, ILE76C, ILE85A, ILE85C, LEU13A, LEU13C, LEU50A, LEU50C, LEU51A, LEU51C, LEU53A, LEU53C, LEU69A, LEU69C, LEU70A, LEU70C, LEU80A, LEU80C, LEU88A, LEU88C, LYS129C, MET43A, MET43C, MET66A, MET66C, MET68A, MET68C, MET83A, MET83C, PHE95A, PHE95C, PRO59A, PRO59C, PRO61A, PRO61C, PRO62A, PRO62C, SER15A, SER15C, SER77A, SER77C, SER87A, SER87C, SER94A, SER94C, THR46A, THR46C, THR71A, THR71C, THR96A, THR96C, VAL133A, VAL133C, VAL57A, VAL57C, VAL60A, VAL60C, VAL81A, VAL81C
• A-E: ALA16A, ALA23A, ALA265E, ALA28A, ALA32A, ALA84A, ALA90A, ARG18A, ARG20A, ARG230A, ARG25A, ARG316E, ARG390E, ASN21A, ASN235A, ASN337E, ASN372E, ASN374E, ASP341E, ASP342E, ASP392E, ASP393E, GLN343E, GLU17A, GLU24A, GLU376E, GLU391E, GLU86A, GLU91A, GLY89A, ILE19A, ILE85A, LEU270E, LEU339E, LEU88A, LYS266E, LYS31A, LYS327E, MET323E, PRO237A, SER15A, SER232A, SER234A, SER87A, THR268E, TYR233A, TYR340E, VAL22A, VAL267E, VAL27A, VAL338E, VAL344E, VAL371E, VAL373E
• A-F: ALA28A, ALA32A, ASN34A, ASP25F, ASP56F, GLY128A, GLY33A, GLY57F, GLY89A, LEU88A, LYS26F, LYS30A, LYS31A, PHE52F, PRO27F, SER24F, THR58F, VAL27A
• A-M: ALA16M, ALA23M, ALA265A, ALA28M, ALA84M, ALA90M, ARG18M, ARG20M, ARG25M, ARG316A, ARG390A, ASN21M, ASN235M, ASN337A, ASN372A, ASN374A, ASP236M, ASP341A, ASP342A, ASP392A, ASP393A, GLN343A, GLU17M, GLU24M, GLU376A, GLU391A, GLU86M, GLU91M, GLY89M, ILE19M, ILE375A, ILE85M, LEU270A, LEU339A, LEU88M, LYS266A, LYS31M, LYS327A, MET323A, PRO237M, SER15M, SER232M, SER234M, SER87M, THR268A, TYR233M, TYR340A, VAL22M, VAL267A, VAL27M, VAL338A, VAL344A, VAL371A, VAL373A
• A-O: ALA265A, ALA285O, ALA287A, ALA287O, ALA289A, ALA289O, ALA322A, ALA322O, ALA54O, ALA55A, ALA55O, ALA56A, ALA56O, ARG284A, ARG284O, ARG320A, ARG320O, ARG321A, ARG321O, ARG64A, ASN337O, ASN58A, ASN58O, ASP288A, ASP288O, ASP341A, ASP341O, ASP342A, ASP342O, GLN332A, GLN332O, GLN343A, GLU290A, GLU290O, GLU324A, GLU324O, GLU52O, GLY319A, GLY319O, ILE291O, ILE325A, ILE325O, LEU286O, LEU326A, LEU326O, LEU329A, LEU339A, LEU339O, LEU51O, LEU53O, LYS327A, LYS327O, LYS328A, LYS328O, MET323A, MET323O, MET66O, PRO59A, PRO59O, PRO61A, PRO61O, PRO62A, PRO62O, TYR340A, TYR340O, VAL267A, VAL338A, VAL338O, VAL57A, VAL57O, VAL60A, VAL60O
• B-M: ALA28M, ALA32M, ALA90M, ASN235M, ASN34M, ASP25B, ASP56B, GLN49B, GLU24M, GLY33M, GLY57B, GLY89M, LEU88M, LYS26B, LYS30M, LYS31M, PHE52B, PRO27B, SER24B, SER53B, THR58B, THR59B, VAL27M
• C-D: ALA103D, ALA113D, ALA118D, ALA205C, ALA206C, ALA220C, ALA222C, ALA265C, ALA279C, ALA280C, ALA285C, ALA287C, ALA289C, ALA30D, ALA31D, ALA362C, ALA367C, ALA36D, ALA38D, ALA40D, ALA4D, ARG120D, ARG135D, ARG141D, ARG215C, ARG221C, ARG284C, ARG316C, ARG35D, ARG369C, ARG384C, ARG390C, ARG72D, ASN123D, ASN125D, ASN292C, ASN299C, ASN372C, ASN374C, ASN43D, ASN50D, ASP121D, ASP25D, ASP261C, ASP274C, ASP288C, ASP294C, ASP309C, ASP318C, ASP341C, ASP370C, ASP393C, ASP39D, ASP45D, ASP60D, ASP92D, CYS314C, GLN155D, GLN298C, GLN404C, GLN49D, GLU114D, GLU117D, GLU127D, GLU133D, GLU15D, GLU199C, GLU200C, GLU203C, GLU218C, GLU264C, GLU278C, GLU290C, GLU29D, GLU363C, GLU366C, GLU376C, GLU382C, GLU3D, GLU41D, GLY102D, GLY104D, GLY110D, GLY153C, GLY208C, GLY277C, GLY28D, GLY353C, GLY359C, GLY8D, HIS108D, HIS357C, ILE126D, ILE129D, ILE134D, ILE136D, ILE140D, ILE23D, ILE272C, ILE291C, ILE293C, ILE310C, ILE375C, ILE378C, ILE383C, ILE385C, ILE389C, ILE42D, ILE44D, ILE61D, LEU119D, LEU128D, LEU139D, LEU202C, LEU204C, LEU214C, LEU21D, LEU270C, LEU286C, LEU297C, LEU339C, LEU368C, LEU377C, LEU37D, LEU388C, LEU48D, LEU6D, LEU90D, LYS106D, LYS17D, LYS210C, LYS266C, LYS26D, LYS275C, LYS281C, LYS32D, LYS346C, LYS355C, LYS97D, MET105D, MET116D, MET201C, MET245C, MET295C, MET354C, MET365C, MET46D, PHE115D, PHE156D, PHE198C, PHE283C, PHE312C, PHE34D, PHE364C, PHE52D, PHE63D, PRO109D, PRO276C, PRO27D, PRO315C, PRO358C, SER107D, SER130D, SER132D, SER137D, SER216C, SER24D, SER263C, SER273C, SER356C, SER379C, SER381C, SER386C, THR112D, THR131D, THR156C, THR19D, THR268C, THR308C, THR311C, THR313C, THR361C, THR380C, THR59D, THR62D, THR64D, THR7D, TYR219C, VAL101D, VAL111D, VAL122D, VAL124D, VAL138D, VAL18D, VAL207C, VAL20D, VAL213C, VAL217C, VAL267C, VAL269C, VAL282C, VAL296C, VAL300C, VAL33D, VAL344C, VAL350C, VAL360C, VAL371C, VAL373C, VAL387C, VAL47D, VAL51D, VAL5D
• C-E: ALA265C, ALA265E, ALA287C, ALA287E, ALA289C, ALA289E, ALA322C, ALA322E, ALA54C, ALA55C, ALA55E, ALA56C, ALA56E, ARG284E, ARG316C, ARG320C, ARG320E, ARG321C, ARG321E, ASN58C, ASN58E, ASP288C, ASP288E, ASP341C, ASP341E, ASP342C, ASP342E, GLN330C, GLN330E, GLN332C, GLN343C, GLN343E, GLU290C, GLU290E, GLU324C, GLU324E, GLU52C, GLY319C, GLY319E, ILE291C, ILE291E, ILE325C, ILE325E, LEU286E, LEU326C, LEU326E, LEU329C, LEU329E, LEU339C, LEU339E, LEU51C, LYS327C, LYS327E, LYS328C, LYS328E, MET323C, MET323E, PRO59C, PRO59E, PRO61C, PRO61E, PRO62C, PRO62E, TYR340C, TYR340E, VAL267C, VAL267E, VAL338C, VAL338E, VAL57C, VAL57E, VAL60C, VAL60E
• C-F: LYS328C, PRO109F
• C-G: ALA16G, ALA23G, ALA265C, ALA28G, ALA84G, ALA90G, ARG18G, ARG20G, ARG230G, ARG25G, ARG316C, ARG390C, ASN21G, ASN235G, ASN337C, ASN372C, ASN374C, ASP236G, ASP341C, ASP342C, ASP392C, ASP393C, GLN343C, GLU17G, GLU24G, GLU376C, GLU391C, GLU86G, GLU91G, GLY89G, ILE19G, ILE85G, LEU270C, LEU339C, LEU88G, LYS266C, LYS31G, LYS327C, MET323C, PRO237G, SER15G, SER232G, SER234G, SER87G, THR268C, TYR233G, TYR340C, VAL22G, VAL267C, VAL27G, VAL338C, VAL344C, VAL371C, VAL373C
• C-O: ALA16C, ALA23C, ALA265O, ALA28C, ALA32C, ALA84C, ALA90C, ARG20C, ARG25C, ARG390O, ASN21C, ASN235C, ASN337O, ASN372O, ASN374O, ASP341O, ASP342O, ASP392O, ASP393O, GLN343O, GLU17C, GLU24C, GLU376O, GLU391O, GLU86C, GLU91C, GLY89C, ILE375O, ILE389O, ILE85C, LEU270O, LEU339O, LEU377O, LEU388O, LEU88C, LYS266O, LYS31C, SER234C, SER87C, THR268O, THR336O, TYR233C, TYR340O, VAL27C, VAL338O, VAL344O, VAL371O
• C-P: ALA124C, ALA28C, ALA32C, ALA90C, ALA92C, ASN34C, ASN50P, ASP126C, ASP25P, ASP35C, ASP56P, GLN49P, GLU127C, GLU29P, GLU55P, GLU86C, GLU91C, GLY128C, GLY33C, GLY57P, GLY89C, ILE130C, ILE23P, ILE85C, LEU125C, LEU88C, LYS129C, LYS26P, LYS30C, LYS31C, PHE52P, PRO27P, SER24P, SER53P, SER87C, THR29C, THR58P, THR59P, VAL27C, VAL36C, VAL51P, VAL54P
• D-G: ALA28G, ALA32G, ASN235G, ASN34G, ASP25D, ASP56D, GLY33G, GLY57D, LEU88G, LYS26D, LYS30G, LYS31G, PHE52D, PRO27D, SER24D, THR58D, VAL27G, VAL51D
• E-F: ALA103F, ALA113F, ALA118F, ALA205E, ALA206E, ALA220E, ALA222E, ALA265E, ALA279E, ALA280E, ALA285E, ALA287E, ALA289E, ALA30F, ALA31F, ALA362E, ALA367E, ALA36F, ALA38F, ALA40F, ALA4F, ARG120F, ARG135F, ARG151E, ARG215E, ARG221E, ARG284E, ARG316E, ARG35F, ARG369E, ARG384E, ASN123F, ASN125F, ASN292E, ASN299E, ASN372E, ASN374E, ASN43F, ASN50F, ASP121F, ASP144F, ASP25F, ASP261E, ASP274E, ASP288E, ASP294E, ASP309E, ASP318E, ASP370E, ASP39F, ASP45F, ASP60F, ASP69F, CYS314E, GLN155F, GLN298E, GLN404E, GLN49F, GLU114F, GLU117F, GLU127F, GLU133F, GLU199E, GLU200E, GLU203E, GLU218E, GLU264E, GLU278E, GLU290E, GLU29F, GLU363E, GLU366E, GLU376E, GLU382E, GLU41F, GLY102F, GLY104F, GLY110F, GLY150E, GLY152E, GLY153E, GLY208E, GLY271E, GLY277E, GLY28F, GLY353E, GLY359E, GLY8F, HIS108F, HIS357E, ILE126F, ILE129F, ILE134F, ILE136F, ILE140F, ILE23F, ILE272E, ILE291E, ILE293E, ILE310E, ILE375E, ILE378E, ILE383E, ILE385E, ILE42F, ILE44F, ILE61F, LEU119F, LEU128F, LEU139F, LEU149E, LEU202E, LEU204E, LEU214E, LEU21F, LEU270E, LEU286E, LEU297E, LEU339E, LEU368E, LEU377E, LEU37F, LEU388E, LEU48F, LEU6F, LYS106F, LYS17F, LYS210E, LYS266E, LYS26F, LYS275E, LYS281E, LYS32F, LYS346E, LYS355E, LYS97F, MET105F, MET116F, MET201E, MET295E, MET354E, MET365E, MET46F, PHE115F, PHE198E, PHE223E, PHE283E, PHE312E, PHE34F, PHE364E, PHE52F, PHE63F, PRO109F, PRO276E, PRO27F, PRO315E, PRO358E, SER107F, SER130F, SER132F, SER137F, SER216E, SER24F, SER263E, SER273E, SER356E, SER379E, SER381E, SER386E, THR112F, THR131F, THR156E, THR19F, THR268E, THR308E, THR311E, THR313E, THR361E, THR380E, THR59F, THR62F, THR64F, THR7F, TYR219E, VAL101F, VAL111F, VAL122F, VAL124F, VAL138F, VAL18F, VAL207E, VAL20F, VAL213E, VAL217E, VAL267E, VAL269E, VAL282E, VAL296E, VAL33F, VAL360E, VAL371E, VAL373E, VAL387E, VAL47F, VAL51F, VAL5F
• E-G: ALA134E, ALA134G, ALA16E, ALA16G, ALA23E, ALA23G, ALA42E, ALA42G, ALA54E, ALA54G, ALA55E, ALA55G, ALA56E, ALA56G, ALA63E, ALA63G, ALA72E, ALA72G, ALA79E, ALA79G, ALA82E, ALA82G, ALA84E, ALA84G, ALA90E, ALA92E, ALA92G, ARG18E, ARG18G, ARG20E, ARG20G, ARG64E, ARG64G, ARG75E, ARG75G, ASN21E, ASN21G, ASN58E, ASN58G, ASN78E, ASN78G, ASP67E, ASP67G, GLN93E, GLN93G, GLU14E, GLU14G, GLU17E, GLU17G, GLU49E, GLU49G, GLU52E, GLU52G, GLU65E, GLU65G, GLU74E, GLU74G, GLU86E, GLU86G, GLU91E, GLY73E, GLY73G, GLY89E, ILE132E, ILE132G, ILE19E, ILE19G, ILE76E, ILE76G, ILE85E, ILE85G, LEU13E, LEU13G, LEU50E, LEU50G, LEU51E, LEU51G, LEU53E, LEU53G, LEU69E, LEU69G, LEU70E, LEU70G, LEU80E, LEU80G, LEU88E, LEU88G, LYS129E, MET43E, MET43G, MET66E, MET66G, MET68E, MET68G, MET83E, MET83G, PHE95E, PHE95G, PRO59E, PRO59G, PRO61E, PRO61G, PRO62E, PRO62G, SER15E, SER15G, SER77E, SER77G, SER87E, SER87G, SER94E, SER94G, THR46E, THR46G, THR71E, THR71G, THR96E, THR96G, VAL133G, VAL57E, VAL57G, VAL60E, VAL60G, VAL81E, VAL81G
• E-I: ALA16E, ALA23E, ALA265I, ALA28E, ALA84E, ALA90E, ARG18E, ARG20E, ARG230E, ARG25E, ARG316I, ARG390I, ASN21E, ASN235E, ASN337I, ASN372I, ASN374I, ASP236E, ASP341I, ASP342I, ASP392I, ASP393I, GLN343I, GLU17E, GLU24E, GLU376I, GLU391I, GLU86E, GLU91E, GLY89E, ILE19E, ILE85E, LEU270I, LEU339I, LEU88E, LYS266I, LYS31E, LYS327I, MET323I, MET83E, PRO237E, SER15E, SER232E, SER234E, SER87E, THR268I, TYR233E, TYR340I, VAL22E, VAL267I, VAL27E, VAL338I, VAL344I, VAL373I
• E-J: ALA28E, ALA32E, ALA90E, ASN235E, ASP25J, GLU91E, GLY33E, GLY89E, LEU88E, LYS26J, LYS31E, PHE52J, PRO27J, SER24J, SER53J, THR58J, THR59J, VAL27E
• G-H: ALA103H, ALA113H, ALA118H, ALA205G, ALA206G, ALA222G, ALA265G, ALA279G, ALA280G, ALA285G, ALA287G, ALA289G, ALA30H, ALA31H, ALA362G, ALA367G, ALA36H, ALA38H, ALA40H, ARG120H, ARG135H, ARG141H, ARG215G, ARG221G, ARG284G, ARG316G, ARG35H, ARG369G, ARG384G, ASN123H, ASN125H, ASN292G, ASN299G, ASN372G, ASN374G, ASN43H, ASN50H, ASN88H, ASP121H, ASP144H, ASP25H, ASP261G, ASP274G, ASP288G, ASP294G, ASP309G, ASP318G, ASP370G, ASP393G, ASP39H, ASP45H, ASP60H, CYS314G, GLN155H, GLN298G, GLN49H, GLU114H, GLU117H, GLU127H, GLU133H, GLU15H, GLU199G, GLU203G, GLU218G, GLU264G, GLU278G, GLU290G, GLU29H, GLU363G, GLU366G, GLU376G, GLU382G, GLU41H, GLY102H, GLY104H, GLY110H, GLY208G, GLY271G, GLY277G, GLY28H, GLY353G, GLY359G, GLY8H, HIS357G, ILE126H, ILE129H, ILE134H, ILE136H, ILE140H, ILE272G, ILE291G, ILE293G, ILE310G, ILE375G, ILE378G, ILE383G, ILE385G, ILE42H, ILE44H, ILE61H, LEU119H, LEU128H, LEU139H, LEU202G, LEU204G, LEU214G, LEU21H, LEU270G, LEU286G, LEU297G, LEU339G, LEU368G, LEU377G, LEU37H, LEU388G, LEU48H, LEU6H, LEU90H, LYS106H, LYS17H, LYS266G, LYS26H, LYS275G, LYS281G, LYS32H, LYS346G, LYS355G, LYS97H, MET105H, MET116H, MET201G, MET295G, MET354G, MET365G, MET46H, PHE115H, PHE283G, PHE301G, PHE312G, PHE34H, PHE364G, PHE52H, PHE63H, PRO109H, PRO276G, PRO27H, PRO315G, PRO358G, SER130H, SER132H, SER137H, SER209G, SER216G, SER24H, SER263G, SER273G, SER356G, SER379G, SER381G, SER386G, SER53H, THR112H, THR131H, THR19H, THR268G, THR308G, THR311G, THR313G, THR361G, THR380G, THR59H, THR62H, THR64H, THR7H, TYR219G, VAL101H, VAL111H, VAL122H, VAL124H, VAL138H, VAL18H, VAL207G, VAL20H, VAL213G, VAL217G, VAL267G, VAL269G, VAL282G, VAL296G, VAL300G, VAL33H, VAL360G, VAL371G, VAL373G, VAL387G, VAL47H, VAL51H, VAL54H, VAL89H
• G-I: ALA265G, ALA285G, ALA287G, ALA287I, ALA289G, ALA289I, ALA322G, ALA322I, ALA55G, ALA55I, ALA56G, ALA56I, ARG284G, ARG316I, ARG320G, ARG320I, ARG321G, ARG321I, ASN337G, ASN58G, ASN58I, ASP288G, ASP288I, ASP341G, ASP341I, ASP342G, ASP342I, GLN330G, GLN330I, GLN332I, GLN343G, GLN343I, GLU290G, GLU290I, GLU324G, GLU324I, GLY319G, GLY319I, ILE291G, ILE325G, ILE325I, LEU326G, LEU326I, LEU329G, LEU329I, LEU339G, LEU339I, LYS327G, LYS327I, LYS328G, LYS328I, MET323G, MET323I, PRO59G, PRO59I, PRO61G, PRO61I, PRO62G, PRO62I, TYR340G, TYR340I, VAL267G, VAL267I, VAL331I, VAL338G, VAL338I, VAL57G, VAL57I, VAL60G, VAL60I
• G-K: ALA16K, ALA23K, ALA28K, ALA84K, ALA90K, ARG18K, ARG20K, ARG316G, ARG390G, ASN21K, ASN235K, ASN337G, ASN372G, ASN374G, ASP341G, ASP342G, ASP392G, GLN343G, GLU17K, GLU24K, GLU376G, GLU391G, GLU86K, GLU91K, GLY89K, ILE19K, ILE375G, ILE85K, LEU270G, LEU339G, LEU88K, LYS266G, LYS31K, MET323G, SER87K, THR268G, THR336G, TYR340G, VAL27K, VAL338G, VAL344G
• H-I: GLN332I, GLU114H, GLU117H
• H-K: ALA124K, ALA28K, ALA32K, ALA90K, ALA92K, ASN34K, ASP126K, ASP25H, ASP56H, GLN49H, GLU127K, GLU55H, GLU86K, GLU91K, GLY128K, GLY33K, GLY57H, GLY89K, ILE130K, ILE85K, LEU125K, LEU88K, LYS129K, LYS26H, LYS30K, LYS31K, PHE52H, PRO27H, SER24H, SER53H, THR58H, THR59H, VAL27K, VAL51H, VAL54H
• I-J: ALA113J, ALA118J, ALA205I, ALA206I, ALA222I, ALA279I, ALA280I, ALA285I, ALA287I, ALA289I, ALA30J, ALA31J, ALA362I, ALA367I, ALA36J, ALA38J, ALA40J, ARG120J, ARG135J, ARG141J, ARG215I, ARG221I, ARG284I, ARG35J, ARG369I, ARG384I, ASN123J, ASN125J, ASN292I, ASN299I, ASN337I, ASN372I, ASN374I, ASN43J, ASN50J, ASP121J, ASP12J, ASP25J, ASP261I, ASP274I, ASP288I, ASP294I, ASP309I, ASP370I, ASP393I, ASP39J, ASP45J, ASP60J, CYS314I, GLN298I, GLN404I, GLN49J, GLU114J, GLU117J, GLU127J, GLU133J, GLU15J, GLU199I, GLU200I, GLU203I, GLU218I, GLU246I, GLU264I, GLU278I, GLU290I, GLU29J, GLU363I, GLU366I, GLU376I, GLU382I, GLU41J, GLY102J, GLY110J, GLY208I, GLY271I, GLY277I, GLY28J, GLY353I, GLY359I, HIS357I, ILE126J, ILE129J, ILE134J, ILE136J, ILE140J, ILE23J, ILE272I, ILE291I, ILE293I, ILE310I, ILE375I, ILE378I, ILE383I, ILE385I, ILE389I, ILE42J, ILE44J, ILE61J, LEU119J, LEU128J, LEU139J, LEU202I, LEU204I, LEU214I, LEU21J, LEU270I, LEU286I, LEU297I, LEU339I, LEU368I, LEU377I, LEU37J, LEU388I, LEU48J, LEU90J, LYS17J, LYS266I, LYS26J, LYS275I, LYS281I, LYS32J, LYS346I, LYS355I, LYS97J, MET116J, MET201I, MET245I, MET295I, MET354I, MET365I, MET46J, PHE115J, PHE198I, PHE283I, PHE301I, PHE312I, PHE34J, PHE364I, PHE52J, PHE63J, PRO276I, PRO27J, PRO315I, PRO358I, SER130J, SER132J, SER137J, SER24J, SER273I, SER302I, SER356I, SER379I, SER381I, SER386I, SER53J, SER99J, THR112J, THR131J, THR19J, THR268I, THR308I, THR311I, THR313I, THR336I, THR361I, THR380I, THR59J, THR62J, THR64J, VAL101J, VAL111J, VAL122J, VAL124J, VAL138J, VAL18J, VAL207I, VAL20J, VAL217I, VAL250I, VAL267I, VAL269I, VAL282I, VAL296I, VAL300I, VAL33J, VAL350I, VAL360I, VAL371I, VAL373I, VAL387I, VAL47J, VAL51J, VAL9J
• I-K: ALA134I, ALA134K, ALA16I, ALA16K, ALA23I, ALA23K, ALA42I, ALA42K, ALA54I, ALA54K, ALA55I, ALA55K, ALA56I, ALA56K, ALA63K, ALA72I, ALA72K, ALA79I, ALA79K, ALA82I, ALA82K, ALA84I, ALA84K, ALA92I, ALA92K, ARG18I, ARG18K, ARG20I, ARG20K, ARG64I, ARG64K, ARG75I, ARG75K, ASN21I, ASN21K, ASN58I, ASN58K, ASN78I, ASN78K, ASP67I, ASP67K, GLN93I, GLN93K, GLU14I, GLU14K, GLU17I, GLU17K, GLU49I, GLU49K, GLU52I, GLU52K, GLU65I, GLU65K, GLU74I, GLU74K, GLU86I, GLU86K, GLU91I, GLU91K, GLY73I, GLY73K, GLY89I, ILE132I, ILE132K, ILE19I, ILE19K, ILE76I, ILE76K, ILE85I, ILE85K, LEU13I, LEU13K, LEU50I, LEU50K, LEU51I, LEU51K, LEU53I, LEU53K, LEU69I, LEU69K, LEU70I, LEU70K, LEU80I, LEU80K, LEU88I, LEU88K, LYS129I, MET43I, MET43K, MET66I, MET66K, MET68I, MET68K, MET83I, MET83K, PHE95I, PHE95K, PRO59I, PRO59K, PRO61I, PRO61K, PRO62I, PRO62K, SER15I, SER15K, SER77I, SER77K, SER87I, SER87K, SER94I, SER94K, THR46I, THR46K, THR47K, THR71I, THR71K, THR96I, THR96K, VAL133I, VAL133K, VAL57I, VAL57K, VAL60I, VAL60K, VAL81I, VAL81K
• I-M: ALA16I, ALA23I, ALA265M, ALA28I, ALA32I, ALA84I, ALA90I, ARG18I, ARG20I, ARG230I, ARG25I, ARG316M, ARG390M, ASN21I, ASN235I, ASN337M, ASN372M, ASN374M, ASP236I, ASP341M, ASP342M, ASP392M, ASP393M, GLN343M, GLU17I, GLU24I, GLU376M, GLU391M, GLU86I, GLU91I, GLY89I, ILE19I, ILE375M, ILE85I, LEU270M, LEU339M, LEU377M, LEU88I, LYS266M, LYS31I, LYS327M, MET323M, MET83I, PRO237I, SER232I, SER234I, SER87I, THR268M, TYR233I, TYR340M, VAL22I, VAL267M, VAL27I, VAL338M, VAL344M, VAL371M, VAL373M
• I-N: ALA28I, ALA32I, ALA90I, ASN235I, ASN34I, ASP25N, ASP56N, GLN49N, GLU55N, GLU91I, GLY128I, GLY33I, GLY57N, GLY89I, ILE130I, ILE85I, LEU88I, LYS129I, LYS26N, LYS30I, LYS31I, PHE52N, PRO27N, SER24N, SER53N, THR58N, THR59N, VAL27I, VAL51N, VAL54N
• K-L: ALA103L, ALA113L, ALA118L, ALA205K, ALA206K, ALA222K, ALA265K, ALA279K, ALA280K, ALA285K, ALA287K, ALA289K, ALA30L, ALA31L, ALA362K, ALA367K, ALA36L, ALA38L, ALA40L, ALA4L, ARG120L, ARG135L, ARG141L, ARG144K, ARG151K, ARG215K, ARG221K, ARG284K, ARG316K, ARG35L, ARG369K, ARG384K, ARG390K, ASN123L, ASN125L, ASN292K, ASN299K, ASN337K, ASN372K, ASN374K, ASN43L, ASN50L, ASP121L, ASP144L, ASP145K, ASP155K, ASP25L, ASP261K, ASP274K, ASP288K, ASP294K, ASP309K, ASP318K, ASP341K, ASP370K, ASP39L, ASP45L, ASP60L, ASP92L, CYS314K, GLN155L, GLN157L, GLN298K, GLN404K, GLN49L, GLU114L, GLU117L, GLU127L, GLU133L, GLU15L, GLU199K, GLU203K, GLU218K, GLU264K, GLU278K, GLU290K, GLU29L, GLU2L, GLU363K, GLU366K, GLU376K, GLU382K, GLU3L, GLU41L, GLU55L, GLY102L, GLY104L, GLY110L, GLY150K, GLY152K, GLY153K, GLY159L, GLY208K, GLY22L, GLY277K, GLY28L, GLY353K, GLY359K, GLY8L, HIS108L, HIS153L, HIS357K, ILE126L, ILE129L, ILE134L, ILE136L, ILE140L, ILE23L, ILE272K, ILE291K, ILE293K, ILE310K, ILE375K, ILE378K, ILE383K, ILE385K, ILE42L, ILE44L, ILE61L, LEU100L, LEU119L, LEU128L, LEU139L, LEU149K, LEU158L, LEU202K, LEU204K, LEU214K, LEU21L, LEU270K, LEU286K, LEU297K, LEU339K, LEU368K, LEU377K, LEU37L, LEU388K, LEU48L, LEU51K, LEU6L, LEU70K, LEU90L, LYS106L, LYS17L, LYS266K, LYS26L, LYS275K, LYS281K, LYS32L, LYS346K, LYS355K, LYS97L, MET105L, MET116L, MET201K, MET295K, MET354K, MET365K, MET46L, PHE115L, PHE156L, PHE223K, PHE283K, PHE301K, PHE312K, PHE34L, PHE364K, PHE405K, PHE52L, PHE63L, PRO109L, PRO276K, PRO27L, PRO315K, PRO358K, SER107L, SER130L, SER132L, SER137L, SER154K, SER209K, SER216K, SER24L, SER263K, SER273K, SER356K, SER379K, SER381K, SER386K, SER53L, THR112L, THR131L, THR143K, THR147K, THR148K, THR156K, THR157K, THR19L, THR268K, THR308K, THR311K, THR313K, THR361K, THR380K, THR59L, THR62L, THR64L, THR7L, TYR219K, VAL101L, VAL111L, VAL122L, VAL124L, VAL138L, VAL146K, VAL18L, VAL207K, VAL20L, VAL213K, VAL217K, VAL267K, VAL269K, VAL282K, VAL296K, VAL300K, VAL33L, VAL344K, VAL360K, VAL371K, VAL373K, VAL387K, VAL47L, VAL51L, VAL54L, VAL5L
• K-M: ALA265K, ALA285K, ALA285M, ALA287K, ALA287M, ALA289K, ALA289M, ALA322K, ALA322M, ALA55K, ALA55M, ALA56K, ALA56M, ARG284K, ARG284M, ARG320K, ARG320M, ARG321K, ARG321M, ASN58K, ASN58M, ASP288K, ASP288M, ASP318M, ASP341K, ASP341M, ASP342K, ASP342M, GLN330K, GLN330M, GLN332K, GLN332M, GLN343K, GLN343M, GLU290K, GLU290M, GLU324K, GLU324M, GLY319K, GLY319M, ILE291K, ILE291M, ILE325K, ILE325M, LEU286K, LEU286M, LEU326K, LEU326M, LEU329K, LEU329M, LEU339K, LEU339M, LYS327K, LYS327M, LYS328K, LYS328M, MET323K, MET323M, PRO59K, PRO59M, PRO61K, PRO61M, PRO62K, PRO62M, SER317M, TYR340K, TYR340M, VAL267K, VAL267M, VAL331K, VAL331M, VAL338K, VAL338M, VAL57K, VAL57M, VAL60K, VAL60M
• K-N: GLY110N, LYS328K, PRO109N
• K-O: ALA16O, ALA23O, ALA265K, ALA28O, ALA84O, ALA90O, ARG18O, ARG20O, ARG230O, ARG25O, ARG316K, ARG390K, ASN21O, ASN235O, ASN337K, ASN372K, ASN374K, ASP236O, ASP341K, ASP342K, ASP392K, ASP393K, GLN343K, GLU17O, GLU24O, GLU376K, GLU391K, GLU86O, GLU91O, GLY89O, ILE19O, ILE375K, ILE85O, LEU270K, LEU339K, LEU88O, LYS266K, LYS31O, LYS327K, MET323K, MET83O, PRO237O, SER15O, SER232O, SER234O, SER87O, THR268K, TYR233O, TYR340K, VAL22O, VAL267K, VAL27O, VAL338K, VAL344K, VAL371K, VAL373K
• L-M: GLY110L, HIS108L, LYS328M, PRO109L, SER107L
• L-O: ALA28O, ALA32O, ALA90O, ASN235O, ASP25L, ASP56L, GLU127O, GLU24O, GLU55L, GLU86O, GLU91O, GLY128O, GLY33O, GLY57L, GLY89O, ILE130O, ILE85O, LEU88O, LYS26L, LYS30O, LYS31O, PHE52L, PRO27L, SER24L, SER53L, THR58L, THR59L, VAL27O, VAL51L, VAL54L
• M-N: ALA103N, ALA113N, ALA118N, ALA205M, ALA206M, ALA222M, ALA265M, ALA279M, ALA280M, ALA285M, ALA287M, ALA289M, ALA30N, ALA31N, ALA362M, ALA367M, ALA36N, ALA38N, ALA40N, ALA4N, ARG120N, ARG135N, ARG151M, ARG215M, ARG221M, ARG284M, ARG316M, ARG35N, ARG369M, ARG384M, ARG390M, ASN123N, ASN125N, ASN292M, ASN299M, ASN337M, ASN372M, ASN374M, ASN43N, ASN50N, ASP121N, ASP144N, ASP25N, ASP261M, ASP274M, ASP288M, ASP294M, ASP309M, ASP318M, ASP341M, ASP370M, ASP39N, ASP45N, ASP60N, ASP92N, CYS314M, GLN155N, GLN157N, GLN298M, GLN404M, GLN49N, GLU114N, GLU117N, GLU127N, GLU133N, GLU15N, GLU199M, GLU200M, GLU203M, GLU218M, GLU264M, GLU278M, GLU290M, GLU29N, GLU363M, GLU366M, GLU376M, GLU382M, GLU41N, GLU55N, GLY102N, GLY104N, GLY110N, GLY150M, GLY152M, GLY153M, GLY208M, GLY22N, GLY277M, GLY28N, GLY353M, GLY359M, GLY8N, HIS108N, HIS357M, ILE126N, ILE129N, ILE134N, ILE136N, ILE140N, ILE23N, ILE272M, ILE291M, ILE293M, ILE310M, ILE375M, ILE378M, ILE383M, ILE385M, ILE389M, ILE42N, ILE44N, ILE61N, LEU100N, LEU119N, LEU128N, LEU139N, LEU149M, LEU158N, LEU202M, LEU204M, LEU214M, LEU21N, LEU270M, LEU286M, LEU297M, LEU339M, LEU368M, LEU377M, LEU37N, LEU388M, LEU48N, LEU6N, LEU90N, LYS106N, LYS17N, LYS266M, LYS26N, LYS275M, LYS281M, LYS32N, LYS346M, LYS355M, LYS97N, MET105N, MET116N, MET201M, MET245M, MET295M, MET354M, MET365M, MET46N, PHE115N, PHE156N, PHE198M, PHE283M, PHE301M, PHE312M, PHE34N, PHE364M, PHE405M, PHE52N, PHE63N, PRO109N, PRO276M, PRO27N, PRO315M, PRO358M, SER107N, SER130N, SER132N, SER137N, SER209M, SER216M, SER24N, SER263M, SER273M, SER356M, SER379M, SER381M, SER386M, SER53N, THR112N, THR131N, THR147M, THR148M, THR156M, THR19N, THR268M, THR308M, THR311M, THR313M, THR361M, THR380M, THR59N, THR62N, THR64N, THR7N, TYR219M, TYR91N, VAL101N, VAL111N, VAL122N, VAL124N, VAL138N, VAL146M, VAL18N, VAL207M, VAL20N, VAL213M, VAL217M, VAL267M, VAL269M, VAL282M, VAL296M, VAL300M, VAL33N, VAL344M, VAL360M, VAL371M, VAL373M, VAL387M, VAL47N, VAL51N, VAL54N, VAL5N
• M-O: ALA134M, ALA134O, ALA16M, ALA16O, ALA23M, ALA23O, ALA42M, ALA54M, ALA54O, ALA55M, ALA55O, ALA56M, ALA56O, ALA63M, ALA63O, ALA72M, ALA72O, ALA79M, ALA79O, ALA82M, ALA82O, ALA84M, ALA84O, ALA92M, ALA92O, ARG18M, ARG18O, ARG20M, ARG20O, ARG64M, ARG64O, ARG75M, ARG75O, ASN21M, ASN21O, ASN58M, ASN58O, ASN78M, ASN78O, ASP115O, ASP67M, ASP67O, CYS40M, GLN93M, GLN93O, GLU14M, GLU14O, GLU17M, GLU17O, GLU49M, GLU49O, GLU52M, GLU52O, GLU65M, GLU65O, GLU74M, GLU74O, GLU86M, GLU86O, GLY73M, GLY73O, GLY89M, GLY89O, ILE132M, ILE132O, ILE19M, ILE19O, ILE76M, ILE76O, ILE85M, ILE85O, LEU13M, LEU13O, LEU50M, LEU50O, LEU51M, LEU51O, LEU53M, LEU53O, LEU69M, LEU69O, LEU70M, LEU70O, LEU80M, LEU80O, LEU88M, LEU88O, LYS129O, MET43M, MET43O, MET66M, MET66O, MET68M, MET68O, MET83M, MET83O, PHE95M, PHE95O, PRO59M, PRO59O, PRO61M, PRO61O, PRO62M, PRO62O, SER15M, SER15O, SER77M, SER77O, SER87M, SER87O, SER94M, SER94O, THR46M, THR46O, THR47M, THR71M, THR71O, THR96M, THR96O, VAL133M, VAL57M, VAL57O, VAL60M, VAL60O, VAL81M, VAL81O
• O-P: ALA103P, ALA113P, ALA118P, ALA205O, ALA206O, ALA222O, ALA279O, ALA280O, ALA285O, ALA287O, ALA289O, ALA30P, ALA31P, ALA362O, ALA367O, ALA36P, ALA38P, ALA40P, ARG120P, ARG135P, ARG151O, ARG215O, ARG221O, ARG284O, ARG35P, ARG369O, ARG384O, ARG390O, ASN123P, ASN125P, ASN292O, ASN299O, ASN337O, ASN372O, ASN374O, ASN43P, ASN50P, ASP121P, ASP25P, ASP274O, ASP288O, ASP294O, ASP309O, ASP318O, ASP341O, ASP370O, ASP393O, ASP39P, ASP45P, ASP60P, GLN298O, GLN404O, GLN49P, GLU114P, GLU117P, GLU127P, GLU133P, GLU199O, GLU203O, GLU218O, GLU264O, GLU278O, GLU290O, GLU29P, GLU363O, GLU366O, GLU376O, GLU382O, GLU41P, GLY102P, GLY110P, GLY208O, GLY271O, GLY277O, GLY28P, GLY353O, GLY359O, GLY8P, HIS108P, HIS357O, ILE126P, ILE129P, ILE134P, ILE136P, ILE140P, ILE23P, ILE291O, ILE293O, ILE310O, ILE375O, ILE378O, ILE383O, ILE385O, ILE389O, ILE42P, ILE44P, ILE61P, LEU119P, LEU128P, LEU139P, LEU202O, LEU204O, LEU214O, LEU21P, LEU270O, LEU286O, LEU297O, LEU339O, LEU368O, LEU377O, LEU37P, LEU388O, LEU48P, LEU6P, LYS17P, LYS210O, LYS266O, LYS26P, LYS275O, LYS281O, LYS32P, LYS346O, LYS355O, LYS97P, MET116P, MET201O, MET245O, MET295O, MET354O, MET365O, MET46P, PHE115P, PHE283O, PHE312O, PHE34P, PHE364O, PHE405O, PHE52P, PHE63P, PRO109P, PRO276O, PRO27P, PRO315O, PRO358O, PRO66P, SER130P, SER132P, SER137P, SER216O, SER24P, SER273O, SER356O, SER379O, SER381O, SER386O, SER53P, THR112P, THR131P, THR19P, THR268O, THR308O, THR311O, THR313O, THR361O, THR380O, THR59P, THR62P, THR64P, THR7P, TYR219O, VAL101P, VAL111P, VAL122P, VAL124P, VAL138P, VAL207O, VAL20P, VAL213O, VAL217O, VAL267O, VAL269O, VAL282O, VAL296O, VAL33P, VAL360O, VAL371O, VAL373O, VAL387O, VAL47P, VAL51P, VAL54P, VAL5P