3A68

crystal structure of plant ferritin reveals a novel metal binding site that functions as a transit site for metal transfer in ferritin

• Total interactions analyzed: 276
• Total true interactions: 84
• Strongest Interaction:
  • Chains: E-I
  • Int. Res.: 142
  • Norm. En. per Res.: -4.5072
• Hub Node: C(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-F	0.0	0.0	-0.0033	-0.0033	2	0	0	3	0	0	0
A-G	-120.2908	-20.4907	-489.837	-630.6185	147	21	7	17667	6	79	65
A-H	-20.6092	22.3799	-321.265	-319.4943	122	16	13	14714	5	41	48
A-J	-18.9267	10.352	-170.172	-178.7467	65	4	2	6073	5	23	36
A-O	-14.6506	9.934	-174.544	-179.2606	65	4	2	6063	6	23	36
A-R	0.0	8.0669	-2.0185	6.0483	10	0	0	209	0	0	6
A-X	-17.709	-13.5651	-300.432	-331.7061	121	13	13	14060	4	44	49
B-E	-25.5747	60.6909	-273.058	-237.9418	107	14	12	11742	3	39	44
B-F	-100.8873	-28.4165	-483.67	-612.9738	146	23	7	17376	6	77	70
B-G	-19.6736	10.6345	-175.152	-184.1911	65	5	2	6146	6	23	36
B-H	0.0	8.1237	-2.1288	5.9949	10	0	0	213	0	0	7
B-I	-14.9454	10.7075	-171.43	-175.6679	65	5	2	6063	7	23	36
B-L	0.0	0.0	-0.0118	-0.0118	3	0	0	8	0	0	0
B-O	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
B-V	-20.7042	12.9001	-335.007	-342.8112	126	18	13	15043	4	43	48
C-F	-24.3287	10.0404	-173.871	-188.1593	64	5	2	6105	7	24	36
C-G	0.0	0.0	-0.0118	-0.0118	2	0	0	4	0	0	0
C-M	-15.7251	11.3133	-172.153	-176.5649	66	4	2	6111	6	23	36
C-N	0.0	0.0	-0.0048	-0.0048	2	0	0	1	0	0	0
C-O	-119.4478	-24.767	-488.015	-632.2297	144	24	7	17399	6	79	65
C-R	-32.0114	1.3247	-327.597	-358.2837	128	23	12	15244	4	42	48
C-S	-27.0953	-32.167	-317.884	-377.1463	121	13	12	14373	4	42	49
C-V	0.0	8.1455	-2.115	6.0304	10	0	0	214	0	0	6
D-H	-93.5885	-27.1493	-491.398	-612.1357	146	23	7	17623	6	79	65
D-I	-41.7506	32.5478	-329.854	-339.0568	125	19	13	14673	3	42	49
D-K	-17.5004	-26.0666	-176.213	-219.78	65	4	2	6134	7	25	35
D-Q	0.0	8.2232	-2.1841	6.0391	10	0	0	216	0	0	7
D-W	-32.6468	16.2614	-325.915	-342.3003	124	7	13	14722	3	43	48
D-X	-16.6228	-24.1974	-173.39	-214.2102	65	4	2	6087	7	23	36
E-I	-117.9113	-42.4776	-479.631	-640.0199	142	22	7	17735	7	79	65
E-L	-15.4026	-24.8967	-175.865	-216.1643	65	4	2	6116	6	23	36
E-P	0.0	8.2341	-2.1534	6.0808	10	0	0	212	0	0	6
E-V	-20.9373	26.2592	-334.419	-329.0971	122	12	11	14787	5	40	46
E-W	-28.288	-24.3126	-173.712	-226.3126	64	5	2	6099	7	24	36
F-G	-31.6791	5.124	-294.61	-321.1651	123	13	13	13962	4	41	48
F-M	0.0	8.2195	-2.2169	6.0026	10	0	0	217	0	0	7
F-O	-24.5254	19.4354	-316.63	-321.72	119	19	13	14634	4	44	48
F-V	-25.5172	10.8049	-174.365	-189.0772	65	4	2	6114	7	23	35
G-H	-17.5315	-25.5822	-174.963	-218.0767	65	4	2	6090	6	24	36
G-I	0.0	8.1879	-2.1533	6.0346	10	0	0	213	0	0	6
G-O	-22.0734	35.7276	-332.552	-318.8978	124	16	12	14847	2	42	49
G-X	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
H-I	-11.164	10.4049	-171.649	-172.4081	64	4	2	6045	5	23	36
H-W	0.0	0.0	-0.0596	-0.0596	2	0	0	15	0	0	0
H-X	-24.0421	15.8609	-312.416	-320.5973	121	11	12	14189	4	41	50
I-W	-27.685	3.8744	-332.446	-356.2566	122	20	12	15092	4	40	46
J-N	-15.521	26.753	-329.575	-318.343	122	17	13	15172	3	43	48
J-O	0.0	8.2249	-2.1473	6.0776	10	0	0	215	0	0	7
J-Q	-17.6242	7.9613	-316.338	-326.0009	123	11	12	14479	6	41	48
J-R	-17.5338	-24.9449	-176.132	-218.6106	64	4	2	6075	7	23	36
J-X	-119.6269	-36.9502	-493.939	-650.5161	146	22	7	17808	6	80	65
K-P	-22.2678	17.7411	-329.68	-334.2067	124	13	13	15018	4	39	49
K-Q	-21.3733	-24.9024	-174.656	-220.9316	65	4	2	6110	7	23	36
K-U	-24.2648	15.2368	-310.853	-319.881	124	11	13	14335	5	43	49
K-W	-108.2554	-35.5651	-491.666	-635.4865	146	26	7	17661	6	80	65
K-X	0.0	8.1361	-2.0919	6.0442	10	0	0	210	0	0	6
L-M	-23.4525	40.1565	-326.655	-309.951	119	12	13	14381	2	43	49
L-P	-20.1244	9.4154	-172.564	-183.2731	64	4	2	6033	5	22	36
L-S	0.0	0.0	-0.0015	-0.0015	2	0	0	1	0	0	0
L-T	-18.6033	21.4137	-327.673	-324.8626	120	11	13	14362	4	42	50
L-V	-108.9086	-36.4695	-484.775	-630.1532	145	21	7	17566	6	79	68
L-W	0.0	8.1202	-2.149	5.9712	10	0	0	214	0	0	6
M-P	0.0	0.0	-0.0044	-0.0044	2	0	0	4	0	0	0
M-R	0.0	0.0	-4.8865	-4.8865	8	0	0	191	0	0	0
M-S	-103.41	-29.617	-499.491	-632.518	147	22	7	17856	6	76	69
M-T	-24.1379	32.032	-315.854	-307.9599	121	17	13	14364	4	45	50
M-V	-21.4214	-23.2781	-173.318	-218.0175	64	5	2	6107	6	24	36
N-Q	-23.7211	24.4654	-331.278	-330.5337	125	12	12	14802	4	42	48
N-R	-122.6585	-37.8763	-483.774	-644.3088	146	22	7	17493	5	80	66
N-S	-17.1399	-25.2779	-173.476	-215.8938	65	4	2	6102	7	25	36
N-T	0.0	8.0666	-2.0156	6.051	10	0	0	207	0	0	6
N-U	-12.4653	9.4443	-172.692	-175.713	65	3	2	6039	6	23	36
O-R	-14.7358	10.1876	-172.66	-177.2082	65	4	2	6090	6	24	36
P-T	-109.2617	-27.0017	-478.871	-615.1344	145	20	8	17306	6	79	66
P-U	-21.8988	37.4794	-314.207	-298.6264	121	10	12	14103	3	42	47
P-W	-13.2115	-23.7952	-176.134	-213.1407	64	4	2	6052	6	23	36
Q-U	-113.0699	-26.0691	-490.384	-629.523	145	25	7	17526	4	78	69
Q-X	-15.3519	-25.7337	-173.375	-214.4606	65	5	2	6079	7	23	36
R-S	-28.3994	18.3145	-359.581	-369.6659	128	16	14	15401	4	41	49
S-T	-15.639	-23.8271	-172.157	-211.6232	65	3	2	6031	6	23	36
S-U	0.0	8.1932	-2.2283	5.9648	10	0	0	218	0	0	7
T-U	-22.5511	9.5594	-172.886	-185.8776	65	4	2	6119	6	25	35
T-V	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
U-W	0.0	0.0	-0.0045	-0.0045	2	0	0	3	0	0	0

Interface residues

• A-F: ILE14F, MET116A
• A-G: ALA124A, ALA124G, ALA34A, ALA34G, ALA37A, ALA37G, ALA65A, ALA65G, ALA68A, ALA68G, ALA76A, ALA76G, ALA81A, ALA81G, ALA95A, ALA95G, ARG105A, ARG105G, ARG38A, ARG38G, ARG72A, ARG72G, ARG92A, ARG92G, ASN103A, ASN103G, ASN50A, ASN50G, ASN54A, ASN54G, ASN58A, ASN58G, ASN74A, ASN74G, ASP120A, ASP120G, ASP122A, ASP122G, ASP128G, ASP71A, ASP71G, ASP73A, ASP73G, GLN102A, GLN102G, GLN112A, GLN112G, GLN33A, GLN33G, GLU100A, GLU100G, GLU46A, GLU46G, GLU86A, GLU86G, GLU89A, GLU89G, GLU90A, GLU90G, GLU91A, GLU91G, GLU93A, GLU93G, GLU96A, GLU96G, GLY106A, GLY106G, GLY107A, GLY107G, HIS123A, HIS123G, HIS64A, HIS64G, ILE114A, ILE114G, ILE53A, ILE53G, LEU111A, LEU111G, LEU118A, LEU118G, LEU36A, LEU36G, LEU98A, LEU98G, LYS104A, LYS104G, LYS108A, LYS108G, LYS110A, LYS110G, LYS85A, LYS85G, LYS97A, LYS97G, MET116A, MET116G, MET66A, MET66G, MET99A, MET99G, PHE121A, PHE121G, PHE67A, PHE67G, PHE70A, PHE70G, PHE84A, PHE84G, PRO117A, PRO117G, PRO29A, PRO29G, PRO32A, PRO32G, SER113A, SER113G, SER119A, SER119G, SER35A, SER35G, SER60A, SER60G, SER87A, SER87G, SER88A, SER88G, TYR101A, TYR101G, TYR57A, TYR57G, TYR61A, TYR61G, TYR63A, TYR63G, TYR69A, TYR69G, VAL109A, VAL109G, VAL115A, VAL115G, VAL31A, VAL31G, VAL62A, VAL62G, VAL75A, VAL75G
• A-H: ALA132H, ALA136H, ALA163A, ALA163H, ALA177H, ALA186H, ALA34A, ALA37A, ALA65H, ARG105A, ARG180H, ARG189H, ARG190H, ARG38A, ASN103A, ASN144H, ASN149H, ASN50H, ASN54H, ASN58H, ASP120H, ASP159A, ASP164A, ASP164H, ASP26A, GLN102A, GLN112H, GLN161A, GLN174H, GLN187H, GLN39A, GLN52H, GLU100A, GLU134H, GLU140H, GLU145H, GLU167A, GLU167H, GLU169H, GLU16A, GLU173H, GLU176H, GLU183H, GLU19A, GLU20A, GLU24A, GLU51H, GLU56H, GLY106A, GLY158A, GLY172H, HIS123H, HIS131H, HIS151A, HIS151H, ILE114H, ILE14A, ILE178H, ILE181H, LEU118H, LEU130H, LEU135H, LEU137H, LEU139H, LEU142H, LEU147H, LEU148H, LEU162A, LEU171H, LEU25A, LEU27A, LEU36A, LYS104A, LYS126H, LYS141H, LYS146H, LYS179H, LYS22A, LYS23A, LYS40A, MET116H, MET133H, MET66H, MET99A, PHE121H, PHE15A, PHE165A, PHE18A, PRO117H, PRO17A, PRO29A, PRO32A, SER113H, SER119H, SER138H, SER152H, SER182H, SER35A, SER60H, THR143H, THR155H, THR168A, THR168H, THR30A, TYR101A, TYR170H, TYR184H, TYR41A, TYR57H, TYR61H, TYR63H, VAL115H, VAL160A, VAL166H, VAL175H, VAL185H, VAL21A, VAL28A, VAL31A, VAL55H, VAL59H, VAL62H
• A-J: ALA129J, ALA186A, ALA68J, ALA76J, ALA81J, ARG180A, ARG189A, ARG190A, ARG72J, ARG78J, ASN74J, ASP122J, ASP128J, ASP201A, ASP201J, ASP71J, ASP73J, GLN187A, GLN202A, GLN202J, GLU183A, GLU207A, GLY127J, GLY192A, GLY192J, GLY194A, GLY194J, GLY196A, GLY196J, HIS195A, HIS195J, HIS199A, HIS199J, HIS206A, HIS206J, ILE178A, ILE181A, LEU130J, LEU137A, LEU188A, LEU188J, LEU204A, LEU205J, LEU77J, LEU80J, LYS141A, LYS179A, LYS193A, LYS193J, MET203A, MET203J, PHE200A, PHE200J, PHE67J, PHE70J, SER182A, TRP198A, TRP198J, TYR184A, TYR69J, VAL185A, VAL191A, VAL197A, VAL197J, VAL75J
• A-O: ALA129A, ALA186O, ALA68A, ALA76A, ALA81A, ARG180O, ARG189O, ARG190O, ARG72A, ARG78A, ASN74A, ASP122A, ASP128A, ASP201A, ASP201O, ASP71A, ASP73A, GLN187O, GLN202A, GLN202O, GLU183O, GLU207O, GLY127A, GLY192A, GLY192O, GLY194A, GLY194O, GLY196A, GLY196O, HIS195A, HIS195O, HIS199A, HIS199O, HIS206A, HIS206O, ILE178O, ILE181O, LEU130A, LEU137O, LEU188A, LEU188O, LEU204O, LEU205A, LEU77A, LEU80A, LYS141O, LYS179O, LYS193A, LYS193O, MET203A, MET203O, PHE200A, PHE200O, PHE67A, PHE70A, SER182O, TRP198A, TRP198O, TYR184O, TYR69A, VAL185O, VAL191O, VAL197A, VAL197O, VAL75A
• A-R: GLY196A, GLY196R, HIS195A, HIS195R, HIS199A, HIS199R, TRP198A, TRP198R, VAL191A, VAL191R
• A-X: ALA132A, ALA136A, ALA163A, ALA163X, ALA177A, ALA186A, ALA34X, ALA37X, ALA65A, ARG105X, ARG180A, ARG189A, ARG190A, ARG38X, ASN103X, ASN144A, ASN149A, ASN54A, ASN58A, ASP120A, ASP159X, ASP164A, ASP164X, ASP26X, GLN102X, GLN112A, GLN161X, GLN174A, GLN187A, GLN39X, GLN52A, GLU100X, GLU134A, GLU140A, GLU145A, GLU167A, GLU167X, GLU169A, GLU16X, GLU173A, GLU176A, GLU183A, GLU19X, GLU20X, GLU24X, GLU51A, GLU56A, GLY106X, GLY158X, GLY172A, HIS123A, HIS131A, HIS151A, HIS151X, ILE114A, ILE14X, ILE178A, ILE181A, LEU118A, LEU130A, LEU135A, LEU137A, LEU139A, LEU142A, LEU147A, LEU148A, LEU162X, LEU171A, LEU25X, LEU27X, LEU36X, LYS104X, LYS126A, LYS141A, LYS146A, LYS179A, LYS22X, LYS23X, LYS40X, MET116A, MET133A, MET66A, MET99X, PHE121A, PHE15X, PHE165X, PHE18X, PRO117A, PRO17X, PRO29X, PRO32X, SER113A, SER119A, SER138A, SER152A, SER182A, SER35X, SER60A, THR143A, THR155A, THR168A, THR168X, THR30X, TYR101X, TYR170A, TYR184A, TYR41X, TYR57A, TYR61A, TYR63A, VAL115A, VAL160X, VAL166A, VAL175A, VAL185A, VAL21X, VAL28X, VAL31X, VAL55A, VAL59A, VAL62A
• B-E: ALA132B, ALA136B, ALA163B, ALA163E, ALA177B, ALA186B, ALA34E, ALA37E, ALA65B, ARG105E, ARG180B, ARG189B, ARG190B, ARG38E, ASN103E, ASN144B, ASN149B, ASN58B, ASP159E, ASP164B, ASP164E, ASP26E, GLN102E, GLN161E, GLN174B, GLN187B, GLN39E, GLU100E, GLU134B, GLU140B, GLU145B, GLU167B, GLU167E, GLU169B, GLU173B, GLU176B, GLU183B, GLU19E, GLU20E, GLU24E, GLY106E, GLY158E, GLY172B, HIS123B, HIS131B, HIS151B, HIS151E, ILE178B, ILE181B, LEU118B, LEU130B, LEU135B, LEU137B, LEU139B, LEU142B, LEU147B, LEU148B, LEU162E, LEU171B, LEU25E, LEU27E, LEU36E, LYS104E, LYS126B, LYS141B, LYS146B, LYS179B, LYS22E, LYS23E, LYS40E, MET116B, MET133B, MET66B, MET99E, PHE121B, PHE165E, PHE18E, PRO117B, PRO29E, PRO32E, SER119B, SER138B, SER152B, SER182B, SER35E, THR143B, THR155B, THR168B, THR168E, THR30E, TYR101E, TYR170B, TYR184B, TYR41E, TYR61B, TYR63B, VAL115B, VAL160E, VAL166B, VAL175B, VAL185B, VAL21E, VAL28E, VAL31E, VAL55B, VAL59B, VAL62B
• B-F: ALA124B, ALA34B, ALA34F, ALA37B, ALA37F, ALA65B, ALA65F, ALA68B, ALA68F, ALA76B, ALA76F, ALA81B, ALA81F, ALA95B, ALA95F, ARG105B, ARG105F, ARG38B, ARG38F, ARG72B, ARG72F, ARG92B, ARG92F, ASN103B, ASN103F, ASN50B, ASN50F, ASN54B, ASN54F, ASN58B, ASN58F, ASN74B, ASN74F, ASP120B, ASP120F, ASP122B, ASP122F, ASP128B, ASP128F, ASP71B, ASP71F, ASP73B, ASP73F, GLN102B, GLN102F, GLN112B, GLN112F, GLN33B, GLN33F, GLU100B, GLU100F, GLU46B, GLU46F, GLU86B, GLU86F, GLU89B, GLU89F, GLU90B, GLU90F, GLU91B, GLU91F, GLU93B, GLU93F, GLU96B, GLU96F, GLY106B, GLY106F, GLY107B, GLY107F, HIS123B, HIS64B, HIS64F, ILE114B, ILE114F, ILE53B, ILE53F, LEU111B, LEU111F, LEU118B, LEU118F, LEU36B, LEU36F, LEU98B, LEU98F, LYS104B, LYS104F, LYS108B, LYS108F, LYS110B, LYS110F, LYS85B, LYS85F, LYS97B, LYS97F, MET116B, MET116F, MET66B, MET66F, MET99B, MET99F, PHE121B, PHE121F, PHE67B, PHE67F, PHE70B, PHE70F, PHE84B, PHE84F, PRO117B, PRO117F, PRO29B, PRO29F, PRO32B, PRO32F, SER113B, SER113F, SER119B, SER119F, SER35B, SER35F, SER60B, SER60F, SER87B, SER87F, SER88B, SER88F, TYR101B, TYR101F, TYR57B, TYR57F, TYR61B, TYR61F, TYR63B, TYR63F, TYR69B, TYR69F, VAL109B, VAL109F, VAL115B, VAL115F, VAL31B, VAL31F, VAL62B, VAL62F, VAL75B, VAL75F
• B-G: ALA129B, ALA186G, ALA68B, ALA76B, ALA81B, ARG180G, ARG189G, ARG190G, ARG72B, ARG78B, ASN74B, ASP122B, ASP128B, ASP201B, ASP201G, ASP71B, ASP73B, GLN187G, GLN202B, GLN202G, GLU183G, GLU207G, GLY127B, GLY192B, GLY192G, GLY194B, GLY194G, GLY196B, GLY196G, HIS195B, HIS195G, HIS199B, HIS199G, HIS206B, HIS206G, ILE178G, ILE181G, LEU130B, LEU137G, LEU188B, LEU188G, LEU204G, LEU205B, LEU77B, LEU80B, LYS141G, LYS179G, LYS193B, LYS193G, MET203B, MET203G, PHE200B, PHE200G, PHE67B, PHE70B, SER182G, TRP198B, TRP198G, TYR184G, TYR69B, VAL185G, VAL191G, VAL197B, VAL197G, VAL75B
• B-H: GLY196B, GLY196H, HIS195B, HIS195H, HIS199B, HIS199H, TRP198B, TRP198H, VAL191B, VAL191H
• B-I: ALA129I, ALA186B, ALA68I, ALA76I, ALA81I, ARG180B, ARG189B, ARG190B, ARG72I, ARG78I, ASN74I, ASP122I, ASP128I, ASP201B, ASP201I, ASP71I, ASP73I, GLN187B, GLN202B, GLN202I, GLU183B, GLU207B, GLY127I, GLY192B, GLY192I, GLY194B, GLY194I, GLY196B, GLY196I, HIS195B, HIS195I, HIS199B, HIS199I, HIS206B, HIS206I, ILE178B, ILE181B, LEU130I, LEU137B, LEU188B, LEU188I, LEU204B, LEU205I, LEU77I, LEU80I, LYS141B, LYS179B, LYS193B, LYS193I, MET203B, MET203I, PHE200B, PHE200I, PHE67I, PHE70I, SER182B, TRP198B, TRP198I, TYR184B, TYR69I, VAL185B, VAL191B, VAL197B, VAL197I, VAL75I
• B-L: ILE114L, ILE14B, MET116L
• B-O: LEU111B, PHE18O
• B-V: ALA132V, ALA136V, ALA163B, ALA163V, ALA177V, ALA186V, ALA34B, ALA37B, ALA65V, ARG105B, ARG180V, ARG189V, ARG190V, ARG38B, ASN103B, ASN144V, ASN149V, ASN50V, ASN54V, ASN58V, ASP120V, ASP159B, ASP164B, ASP164V, ASP26B, GLN102B, GLN112V, GLN161B, GLN174V, GLN187V, GLN39B, GLN52V, GLU100B, GLU134V, GLU140V, GLU145V, GLU167B, GLU167V, GLU169V, GLU16B, GLU173V, GLU176V, GLU183V, GLU19B, GLU20B, GLU24B, GLU51V, GLU56V, GLY106B, GLY107B, GLY158B, GLY172V, HIS123V, HIS131V, HIS151B, HIS151V, ILE114V, ILE14B, ILE178V, ILE181V, LEU111V, LEU118V, LEU130V, LEU135V, LEU137V, LEU139V, LEU142V, LEU147V, LEU148V, LEU162B, LEU171V, LEU25B, LEU27B, LEU36B, LYS104B, LYS110V, LYS126V, LYS141V, LYS146V, LYS179V, LYS22B, LYS23B, LYS40B, MET116V, MET133V, MET66V, MET99B, PHE121V, PHE15B, PHE165B, PHE18B, PRO117V, PRO17B, PRO29B, PRO32B, SER113V, SER119V, SER138V, SER152V, SER182V, SER35B, SER60V, THR143V, THR155B, THR155V, THR168B, THR168V, THR30B, TYR101B, TYR170V, TYR184V, TYR41B, TYR57V, TYR61V, TYR63V, VAL115V, VAL160B, VAL166V, VAL175V, VAL185V, VAL21B, VAL28B, VAL31B, VAL55V, VAL59V, VAL62V
• C-F: ALA129C, ALA186F, ALA68C, ALA76C, ALA81C, ARG180F, ARG189F, ARG190F, ARG72C, ARG78C, ASN74C, ASP122C, ASP128C, ASP201C, ASP201F, ASP71C, ASP73C, GLN187F, GLN202C, GLN202F, GLU183F, GLU207F, GLY127C, GLY192C, GLY192F, GLY194C, GLY194F, GLY196C, GLY196F, HIS195C, HIS195F, HIS199C, HIS199F, HIS206C, HIS206F, ILE178F, ILE181F, LEU130C, LEU137F, LEU188F, LEU204F, LEU205C, LEU77C, LEU80C, LYS141F, LYS179F, LYS193C, LYS193F, MET203C, MET203F, PHE200C, PHE200F, PHE67C, PHE70C, SER182F, TRP198C, TRP198F, TYR184F, TYR69C, VAL185F, VAL191F, VAL197C, VAL197F, VAL75C
• C-G: ILE14G, MET116C
• C-M: ALA129M, ALA186C, ALA68M, ALA76M, ALA81M, ARG180C, ARG189C, ARG190C, ARG72M, ARG78M, ASN74M, ASP122M, ASP128M, ASP201C, ASP201M, ASP71M, ASP73M, GLN187C, GLN202C, GLN202M, GLU183C, GLU207C, GLY127M, GLY192C, GLY192M, GLY194C, GLY194M, GLY196C, GLY196M, GLY208C, HIS195C, HIS195M, HIS199C, HIS199M, HIS206C, HIS206M, ILE178C, ILE181C, LEU130M, LEU137C, LEU188C, LEU188M, LEU204C, LEU205M, LEU77M, LEU80M, LYS141C, LYS179C, LYS193C, LYS193M, MET203C, MET203M, PHE200C, PHE200M, PHE67M, PHE70M, SER182C, TRP198C, TRP198M, TYR184C, TYR69M, VAL185C, VAL191C, VAL197C, VAL197M, VAL75M
• C-N: MET116N, VAL13C
• C-O: ALA124C, ALA34C, ALA34O, ALA37C, ALA37O, ALA65C, ALA65O, ALA68C, ALA68O, ALA76C, ALA76O, ALA81C, ALA81O, ALA95C, ALA95O, ARG105C, ARG105O, ARG38C, ARG38O, ARG72C, ARG72O, ARG92C, ARG92O, ASN103C, ASN103O, ASN50C, ASN50O, ASN54C, ASN54O, ASN58C, ASN58O, ASN74C, ASN74O, ASP120C, ASP120O, ASP122C, ASP122O, ASP71C, ASP71O, ASP73C, ASP73O, GLN102C, GLN102O, GLN112C, GLN112O, GLN33C, GLN33O, GLU100C, GLU100O, GLU46C, GLU46O, GLU86C, GLU86O, GLU89C, GLU89O, GLU90C, GLU90O, GLU91C, GLU91O, GLU93C, GLU93O, GLU96C, GLU96O, GLY106C, GLY106O, GLY107C, GLY107O, HIS123C, HIS64C, HIS64O, ILE114C, ILE114O, ILE53C, ILE53O, LEU111C, LEU111O, LEU118C, LEU118O, LEU36C, LEU36O, LEU98C, LEU98O, LYS104C, LYS104O, LYS108C, LYS108O, LYS110C, LYS110O, LYS85C, LYS85O, LYS97C, LYS97O, MET116C, MET116O, MET66C, MET66O, MET99C, MET99O, PHE121C, PHE121O, PHE67C, PHE67O, PHE70C, PHE70O, PHE84C, PHE84O, PRO117C, PRO117O, PRO29C, PRO29O, PRO32C, PRO32O, SER113C, SER113O, SER119C, SER119O, SER35C, SER35O, SER60C, SER60O, SER87C, SER87O, SER88C, SER88O, TYR101C, TYR101O, TYR57C, TYR57O, TYR61C, TYR61O, TYR63C, TYR63O, TYR69C, TYR69O, VAL109C, VAL109O, VAL115C, VAL115O, VAL31C, VAL31O, VAL62C, VAL62O, VAL75C, VAL75O
• C-R: ALA132R, ALA136R, ALA163C, ALA163R, ALA177R, ALA186R, ALA34C, ALA37C, ALA48R, ALA65R, ARG105C, ARG180R, ARG189R, ARG190R, ARG38C, ASN103C, ASN144R, ASN149R, ASN50R, ASN54R, ASN58R, ASP120R, ASP159C, ASP164C, ASP164R, ASP26C, GLN102C, GLN112R, GLN161C, GLN174R, GLN187R, GLN33C, GLN39C, GLN52R, GLU100C, GLU134R, GLU140R, GLU145R, GLU167C, GLU167R, GLU169R, GLU16C, GLU173R, GLU176R, GLU183R, GLU19C, GLU20C, GLU24C, GLU51R, GLU56R, GLY106C, GLY158C, GLY172R, HIS123R, HIS131R, HIS151R, ILE114R, ILE14C, ILE178R, ILE181R, ILE53R, LEU118R, LEU130R, LEU135R, LEU137R, LEU139R, LEU142R, LEU147R, LEU148R, LEU162C, LEU171R, LEU25C, LEU27C, LEU36C, LYS104C, LYS110R, LYS126R, LYS141R, LYS146R, LYS179R, LYS22C, LYS23C, LYS40C, MET116R, MET133R, MET66R, MET99C, PHE121R, PHE15C, PHE165C, PHE18C, PRO117R, PRO17C, PRO29C, PRO32C, SER113R, SER119R, SER138R, SER152R, SER182R, SER35C, SER47R, SER60R, THR143R, THR155R, THR168C, THR168R, THR30C, TYR101C, TYR170R, TYR184R, TYR41C, TYR57R, TYR61R, TYR63R, VAL115R, VAL13C, VAL160C, VAL166R, VAL175R, VAL185R, VAL21C, VAL28C, VAL31C, VAL49R, VAL55R, VAL59R, VAL62R
• C-S: ALA132C, ALA136C, ALA163C, ALA163S, ALA177C, ALA186C, ALA34S, ALA37S, ALA65C, ARG105S, ARG180C, ARG189C, ARG190C, ARG38S, ASN103S, ASN144C, ASN149C, ASN54C, ASN58C, ASP120C, ASP159S, ASP164C, ASP164S, ASP26S, GLN102S, GLN112C, GLN161S, GLN174C, GLN187C, GLN39S, GLN52C, GLU100S, GLU134C, GLU140C, GLU145C, GLU167C, GLU167S, GLU169C, GLU16S, GLU173C, GLU176C, GLU183C, GLU19S, GLU20S, GLU24S, GLU51C, GLU56C, GLY106S, GLY158S, GLY172C, HIS123C, HIS131C, HIS151C, HIS151S, ILE114C, ILE14S, ILE178C, ILE181C, LEU118C, LEU130C, LEU135C, LEU137C, LEU139C, LEU142C, LEU147C, LEU148C, LEU162S, LEU171C, LEU25S, LEU27S, LEU36S, LYS104S, LYS126C, LYS141C, LYS146C, LYS179C, LYS22S, LYS23S, LYS40S, MET116C, MET133C, MET66C, MET99S, PHE121C, PHE15S, PHE165S, PHE18S, PRO117C, PRO17S, PRO29S, PRO32S, SER113C, SER119C, SER138C, SER152C, SER182C, SER35S, SER60C, THR143C, THR155C, THR168C, THR168S, THR30S, TYR101S, TYR170C, TYR184C, TYR41S, TYR57C, TYR61C, TYR63C, VAL115C, VAL160S, VAL166C, VAL175C, VAL185C, VAL21S, VAL28S, VAL31S, VAL55C, VAL59C, VAL62C
• C-V: GLY196C, GLY196V, HIS195C, HIS195V, HIS199C, HIS199V, TRP198C, TRP198V, VAL191C, VAL191V
• D-H: ALA124H, ALA34D, ALA34H, ALA37D, ALA37H, ALA65D, ALA65H, ALA68D, ALA68H, ALA76D, ALA76H, ALA81D, ALA81H, ALA95D, ALA95H, ARG105D, ARG105H, ARG38D, ARG38H, ARG72D, ARG72H, ARG92D, ARG92H, ASN103D, ASN103H, ASN50D, ASN50H, ASN54D, ASN54H, ASN58D, ASN58H, ASN74D, ASN74H, ASP120D, ASP120H, ASP122D, ASP122H, ASP128D, ASP128H, ASP71D, ASP71H, ASP73D, ASP73H, GLN102D, GLN102H, GLN112D, GLN112H, GLN33D, GLN33H, GLU100D, GLU100H, GLU46D, GLU46H, GLU86D, GLU86H, GLU89D, GLU89H, GLU90D, GLU90H, GLU91D, GLU91H, GLU93D, GLU93H, GLU96D, GLU96H, GLY106D, GLY106H, GLY107D, GLY107H, HIS123H, HIS64D, HIS64H, ILE114D, ILE114H, ILE53D, ILE53H, LEU111D, LEU111H, LEU118D, LEU118H, LEU36D, LEU36H, LEU98D, LEU98H, LYS104D, LYS104H, LYS108D, LYS108H, LYS110D, LYS110H, LYS85D, LYS85H, LYS97D, LYS97H, MET116D, MET116H, MET66D, MET66H, MET99D, MET99H, PHE121D, PHE121H, PHE67D, PHE67H, PHE70D, PHE70H, PHE84D, PHE84H, PRO117D, PRO117H, PRO29D, PRO29H, PRO32D, PRO32H, SER113D, SER113H, SER119D, SER119H, SER35D, SER35H, SER60D, SER60H, SER87D, SER87H, SER88D, SER88H, TYR101D, TYR101H, TYR57D, TYR57H, TYR61D, TYR61H, TYR63D, TYR63H, TYR69D, TYR69H, VAL109D, VAL109H, VAL115D, VAL115H, VAL31D, VAL31H, VAL62D, VAL62H, VAL75D, VAL75H
• D-I: ALA132I, ALA136I, ALA163D, ALA163I, ALA177I, ALA186I, ALA34D, ALA37D, ALA65I, ARG105D, ARG180I, ARG189I, ARG190I, ARG38D, ASN103D, ASN144I, ASN149I, ASN50I, ASN54I, ASN58I, ASP120I, ASP159D, ASP164D, ASP164I, ASP26D, GLN102D, GLN112I, GLN161D, GLN174I, GLN187I, GLN39D, GLN52I, GLU100D, GLU134I, GLU140I, GLU145I, GLU167D, GLU167I, GLU169I, GLU16D, GLU173I, GLU176I, GLU183I, GLU19D, GLU20D, GLU24D, GLU51I, GLU56I, GLY106D, GLY158D, GLY172I, HIS123I, HIS131I, HIS151D, HIS151I, ILE114I, ILE14D, ILE178I, ILE181I, ILE53I, LEU118I, LEU130I, LEU135I, LEU137I, LEU139I, LEU142I, LEU147I, LEU148I, LEU162D, LEU171I, LEU25D, LEU27D, LEU36D, LYS104D, LYS126I, LYS141I, LYS146I, LYS156I, LYS179I, LYS22D, LYS23D, LYS40D, MET116I, MET133I, MET66I, MET99D, PHE121I, PHE15D, PHE165D, PHE18D, PRO117I, PRO17D, PRO29D, PRO32D, SER113I, SER119I, SER138I, SER152I, SER182I, SER35D, SER47I, SER60I, THR143I, THR155I, THR168D, THR168I, THR30D, TYR101D, TYR170I, TYR184I, TYR41D, TYR57I, TYR61I, TYR63I, VAL115I, VAL160D, VAL166I, VAL175I, VAL185I, VAL21D, VAL28D, VAL31D, VAL55I, VAL59I, VAL62I
• D-K: ALA129K, ALA186D, ALA68K, ALA76K, ALA81K, ARG180D, ARG189D, ARG190D, ARG72K, ARG78K, ASN74K, ASP122K, ASP128K, ASP201D, ASP201K, ASP71K, ASP73K, GLN187D, GLN202D, GLN202K, GLU183D, GLU207D, GLY127K, GLY192D, GLY192K, GLY194D, GLY194K, GLY196D, GLY196K, HIS195D, HIS195K, HIS199D, HIS199K, HIS206D, HIS206K, ILE178D, ILE181D, LEU130K, LEU137D, LEU188D, LEU188K, LEU204D, LEU205K, LEU77K, LEU80K, LYS141D, LYS179D, LYS193D, LYS193K, MET203D, MET203K, PHE200D, PHE200K, PHE67K, PHE70K, SER182D, TRP198D, TRP198K, TYR184D, TYR69K, VAL185D, VAL191D, VAL197D, VAL197K, VAL75K
• D-Q: GLY196D, GLY196Q, HIS195D, HIS195Q, HIS199D, HIS199Q, TRP198D, TRP198Q, VAL191D, VAL191Q
• D-W: ALA132D, ALA136D, ALA163D, ALA163W, ALA177D, ALA186D, ALA34W, ALA37W, ALA65D, ARG105W, ARG180D, ARG189D, ARG190D, ARG38W, ASN103W, ASN144D, ASN149D, ASN50D, ASN54D, ASN58D, ASP120D, ASP159W, ASP164D, ASP164W, ASP26W, GLN102W, GLN112D, GLN161W, GLN174D, GLN187D, GLN39W, GLN52D, GLU100W, GLU134D, GLU140D, GLU145D, GLU167D, GLU167W, GLU169D, GLU16W, GLU173D, GLU176D, GLU183D, GLU19W, GLU20W, GLU24W, GLU51D, GLU56D, GLY106W, GLY158W, GLY172D, HIS123D, HIS131D, HIS151D, HIS151W, ILE114D, ILE14W, ILE178D, ILE181D, LEU111D, LEU118D, LEU130D, LEU135D, LEU137D, LEU139D, LEU142D, LEU147D, LEU148D, LEU162W, LEU171D, LEU25W, LEU27W, LEU36W, LYS104W, LYS110D, LYS126D, LYS141D, LYS146D, LYS179D, LYS22W, LYS23W, LYS40W, MET116D, MET133D, MET66D, MET99W, PHE121D, PHE15W, PHE165W, PHE18W, PRO117D, PRO17W, PRO29W, PRO32W, SER113D, SER119D, SER138D, SER152D, SER182D, SER35W, SER60D, THR143D, THR155D, THR168D, THR168W, THR30W, TYR101W, TYR170D, TYR184D, TYR41W, TYR57D, TYR61D, TYR63D, VAL115D, VAL160W, VAL166D, VAL175D, VAL185D, VAL21W, VAL28W, VAL31W, VAL55D, VAL59D, VAL62D
• D-X: ALA129D, ALA186X, ALA68D, ALA76D, ALA81D, ARG180X, ARG189X, ARG190X, ARG72D, ARG78D, ASN74D, ASP122D, ASP128D, ASP201D, ASP201X, ASP71D, ASP73D, GLN187X, GLN202D, GLN202X, GLU183X, GLU207X, GLY127D, GLY192D, GLY192X, GLY194D, GLY194X, GLY196D, GLY196X, HIS195D, HIS195X, HIS199D, HIS199X, HIS206D, HIS206X, ILE178X, ILE181X, LEU130D, LEU137X, LEU188D, LEU188X, LEU204X, LEU205D, LEU77D, LEU80D, LYS141X, LYS179X, LYS193D, LYS193X, MET203D, MET203X, PHE200D, PHE200X, PHE67D, PHE70D, SER182X, TRP198D, TRP198X, TYR184X, TYR69D, VAL185X, VAL191X, VAL197D, VAL197X, VAL75D
• E-I: ALA34E, ALA34I, ALA37E, ALA37I, ALA65E, ALA65I, ALA68E, ALA68I, ALA76E, ALA76I, ALA81E, ALA81I, ALA95E, ALA95I, ARG105E, ARG105I, ARG38E, ARG38I, ARG72E, ARG72I, ARG92E, ARG92I, ASN103E, ASN103I, ASN50E, ASN50I, ASN54E, ASN54I, ASN58E, ASN58I, ASN74E, ASN74I, ASP120E, ASP120I, ASP122E, ASP122I, ASP71E, ASP71I, ASP73E, ASP73I, GLN102E, GLN102I, GLN112E, GLN112I, GLN33E, GLN33I, GLU100E, GLU100I, GLU46E, GLU46I, GLU86E, GLU86I, GLU89E, GLU89I, GLU90E, GLU90I, GLU91E, GLU91I, GLU93E, GLU93I, GLU96E, GLU96I, GLY106E, GLY106I, GLY107E, GLY107I, HIS64E, HIS64I, ILE114E, ILE114I, ILE53E, ILE53I, LEU111E, LEU111I, LEU118E, LEU118I, LEU36E, LEU36I, LEU98E, LEU98I, LYS104E, LYS104I, LYS108E, LYS108I, LYS110E, LYS110I, LYS85E, LYS85I, LYS97E, LYS97I, MET116E, MET116I, MET66E, MET66I, MET99E, MET99I, PHE121E, PHE121I, PHE67E, PHE67I, PHE70E, PHE70I, PHE84E, PHE84I, PRO117E, PRO117I, PRO29E, PRO29I, PRO32E, PRO32I, SER113E, SER113I, SER119E, SER119I, SER35E, SER35I, SER60E, SER60I, SER87E, SER87I, SER88E, SER88I, TYR101E, TYR101I, TYR57E, TYR57I, TYR61E, TYR61I, TYR63E, TYR63I, TYR69E, TYR69I, VAL109E, VAL109I, VAL115E, VAL115I, VAL31E, VAL31I, VAL62E, VAL62I, VAL75E, VAL75I
• E-L: ALA129L, ALA186E, ALA68L, ALA76L, ALA81L, ARG180E, ARG189E, ARG190E, ARG72L, ARG78L, ASN74L, ASP122L, ASP128L, ASP201E, ASP201L, ASP71L, ASP73L, GLN187E, GLN202E, GLN202L, GLU183E, GLU207E, GLY127L, GLY192E, GLY192L, GLY194E, GLY194L, GLY196E, GLY196L, HIS195E, HIS195L, HIS199E, HIS199L, HIS206E, HIS206L, ILE178E, ILE181E, LEU130L, LEU137E, LEU188E, LEU188L, LEU204E, LEU205L, LEU77L, LEU80L, LYS141E, LYS179E, LYS193E, LYS193L, MET203E, MET203L, PHE200E, PHE200L, PHE67L, PHE70L, SER182E, TRP198E, TRP198L, TYR184E, TYR69L, VAL185E, VAL191E, VAL197E, VAL197L, VAL75L
• E-P: GLY196E, GLY196P, HIS195E, HIS195P, HIS199E, HIS199P, TRP198E, TRP198P, VAL191E, VAL191P
• E-V: ALA132E, ALA136E, ALA163E, ALA163V, ALA177E, ALA186E, ALA34V, ALA37V, ALA65E, ARG105V, ARG180E, ARG189E, ARG190E, ARG38V, ASN103V, ASN144E, ASN149E, ASN50E, ASN54E, ASN58E, ASP120E, ASP159V, ASP164E, ASP164V, ASP26V, GLN102V, GLN112E, GLN161V, GLN174E, GLN187E, GLN33V, GLN39V, GLN52E, GLU100V, GLU134E, GLU140E, GLU145E, GLU167E, GLU167V, GLU16V, GLU173E, GLU176E, GLU183E, GLU19V, GLU20V, GLU24V, GLU51E, GLU56E, GLY106V, GLY158V, GLY172E, HIS131E, HIS151E, ILE114E, ILE14V, ILE178E, ILE181E, ILE53E, LEU118E, LEU130E, LEU135E, LEU137E, LEU139E, LEU142E, LEU147E, LEU148E, LEU162V, LEU171E, LEU25V, LEU27V, LEU36V, LYS104V, LYS126E, LYS141E, LYS146E, LYS179E, LYS22V, LYS23V, LYS40V, MET116E, MET133E, MET66E, MET99V, PHE121E, PHE15V, PHE165V, PHE18V, PRO117E, PRO17V, PRO29V, PRO32V, SER113E, SER119E, SER138E, SER152E, SER182E, SER35V, SER47E, SER60E, THR143E, THR155E, THR168E, THR168V, THR30V, TYR101V, TYR170E, TYR184E, TYR41V, TYR57E, TYR61E, TYR63E, VAL115E, VAL160V, VAL166E, VAL175E, VAL185E, VAL21V, VAL28V, VAL31V, VAL55E, VAL59E, VAL62E
• E-W: ALA129E, ALA186W, ALA68E, ALA76E, ALA81E, ARG180W, ARG189W, ARG190W, ARG72E, ARG78E, ASN74E, ASP128E, ASP201E, ASP201W, ASP71E, ASP73E, GLN187W, GLN202E, GLN202W, GLU183W, GLU207W, GLY127E, GLY192E, GLY192W, GLY194E, GLY194W, GLY196E, GLY196W, HIS195E, HIS195W, HIS199E, HIS199W, HIS206E, HIS206W, ILE178W, ILE181W, LEU130E, LEU137W, LEU188E, LEU188W, LEU204W, LEU205E, LEU77E, LEU80E, LYS141W, LYS179W, LYS193E, LYS193W, MET203E, MET203W, PHE200E, PHE200W, PHE67E, PHE70E, SER182W, TRP198E, TRP198W, TYR184W, TYR69E, VAL185W, VAL191W, VAL197E, VAL197W, VAL75E
• F-G: ALA132G, ALA136G, ALA163F, ALA163G, ALA177G, ALA186G, ALA34F, ALA37F, ALA65G, ARG105F, ARG180G, ARG189G, ARG190G, ARG38F, ASN103F, ASN144G, ASN149G, ASN54G, ASN58G, ASP120G, ASP159F, ASP164F, ASP164G, ASP26F, GLN102F, GLN112G, GLN161F, GLN174G, GLN187G, GLN39F, GLN52G, GLU100F, GLU134G, GLU140G, GLU145G, GLU167F, GLU167G, GLU169G, GLU16F, GLU173G, GLU176G, GLU183G, GLU19F, GLU20F, GLU24F, GLU51G, GLU56G, GLY106F, GLY107F, GLY158F, GLY172G, HIS123G, HIS131G, HIS151F, HIS151G, ILE114G, ILE14F, ILE178G, ILE181G, LEU118G, LEU130G, LEU135G, LEU137G, LEU139G, LEU142G, LEU147G, LEU148G, LEU162F, LEU171G, LEU25F, LEU27F, LEU36F, LYS104F, LYS126G, LYS141G, LYS146G, LYS179G, LYS22F, LYS23F, LYS40F, MET116G, MET133G, MET66G, MET99F, PHE121G, PHE15F, PHE165F, PHE18F, PRO117G, PRO17F, PRO29F, PRO32F, SER113G, SER119G, SER138G, SER152G, SER182G, SER35F, SER60G, THR143G, THR155F, THR155G, THR168F, THR168G, THR30F, TYR101F, TYR170G, TYR184G, TYR41F, TYR57G, TYR61G, TYR63G, VAL115G, VAL160F, VAL166G, VAL175G, VAL185G, VAL21F, VAL28F, VAL31F, VAL55G, VAL59G, VAL62G
• F-M: GLY196F, GLY196M, HIS195F, HIS195M, HIS199F, HIS199M, TRP198F, TRP198M, VAL191F, VAL191M
• F-O: ALA132F, ALA136F, ALA163F, ALA163O, ALA177F, ALA186F, ALA34O, ALA37O, ALA65F, ARG105O, ARG180F, ARG189F, ARG190F, ARG38O, ASN103O, ASN144F, ASN149F, ASN54F, ASN58F, ASP159O, ASP164F, ASP164O, ASP26O, GLN102O, GLN112F, GLN161O, GLN174F, GLN187F, GLN39O, GLN52F, GLU100O, GLU134F, GLU140F, GLU145F, GLU167F, GLU167O, GLU169F, GLU16O, GLU173F, GLU176F, GLU183F, GLU19O, GLU20O, GLU24O, GLU51F, GLU56F, GLY106O, GLY158O, GLY172F, HIS123F, HIS131F, HIS151F, ILE114F, ILE14O, ILE178F, ILE181F, LEU118F, LEU130F, LEU135F, LEU137F, LEU139F, LEU142F, LEU147F, LEU148F, LEU162O, LEU171F, LEU25O, LEU27O, LEU36O, LYS104O, LYS126F, LYS141F, LYS146F, LYS179F, LYS22O, LYS23O, LYS40O, MET116F, MET133F, MET66F, MET99O, PHE121F, PHE15O, PHE165O, PHE18O, PRO117F, PRO17O, PRO29O, PRO32O, SER113F, SER119F, SER138F, SER152F, SER182F, SER35O, SER60F, THR143F, THR155F, THR168F, THR168O, THR30O, TYR101O, TYR170F, TYR184F, TYR41O, TYR57F, TYR61F, TYR63F, VAL115F, VAL160O, VAL166F, VAL175F, VAL185F, VAL21O, VAL28O, VAL31O, VAL55F, VAL59F, VAL62F
• F-V: ALA129F, ALA186V, ALA68F, ALA76F, ALA81F, ARG180V, ARG189V, ARG190V, ARG72F, ARG78F, ASN74F, ASP122F, ASP128F, ASP201F, ASP201V, ASP71F, ASP73F, GLN187V, GLN202F, GLN202V, GLU183V, GLU207V, GLY127F, GLY192F, GLY192V, GLY194F, GLY194V, GLY196F, GLY196V, HIS195F, HIS195V, HIS199F, HIS199V, HIS206F, HIS206V, ILE178V, ILE181V, LEU130F, LEU137V, LEU188F, LEU188V, LEU204V, LEU205F, LEU77F, LEU80F, LYS141V, LYS179V, LYS193F, LYS193V, MET203F, MET203V, PHE200F, PHE200V, PHE67F, PHE70F, SER182V, TRP198F, TRP198V, TYR184V, TYR69F, VAL185V, VAL191V, VAL197F, VAL197V, VAL75F
• G-H: ALA129G, ALA186H, ALA68G, ALA76G, ALA81G, ARG180H, ARG189H, ARG190H, ARG72G, ARG78G, ASN74G, ASP122G, ASP128G, ASP201G, ASP201H, ASP71G, ASP73G, GLN187H, GLN202G, GLN202H, GLU183H, GLU207H, GLY127G, GLY192G, GLY192H, GLY194G, GLY194H, GLY196G, GLY196H, HIS195G, HIS195H, HIS199G, HIS199H, HIS206G, HIS206H, ILE178H, ILE181H, LEU130G, LEU137H, LEU188G, LEU188H, LEU204H, LEU205G, LEU77G, LEU80G, LYS141H, LYS179H, LYS193G, LYS193H, MET203G, MET203H, PHE200G, PHE200H, PHE67G, PHE70G, SER182H, TRP198G, TRP198H, TYR184H, TYR69G, VAL185H, VAL191H, VAL197G, VAL197H, VAL75G
• G-I: GLY196G, GLY196I, HIS195G, HIS195I, HIS199G, HIS199I, TRP198G, TRP198I, VAL191G, VAL191I
• G-O: ALA132O, ALA136O, ALA163G, ALA163O, ALA177O, ALA186O, ALA34G, ALA37G, ALA65O, ARG105G, ARG180O, ARG189O, ARG190O, ARG38G, ASN103G, ASN144O, ASN149O, ASN50O, ASN54O, ASN58O, ASP120O, ASP159G, ASP164G, ASP164O, ASP26G, GLN102G, GLN112O, GLN161G, GLN174O, GLN187O, GLN39G, GLN52O, GLU100G, GLU134O, GLU140O, GLU145O, GLU167G, GLU167O, GLU169O, GLU16G, GLU173O, GLU176O, GLU183O, GLU19G, GLU20G, GLU24G, GLU51O, GLU56O, GLY106G, GLY158G, GLY172O, HIS123O, HIS131O, HIS151O, ILE114O, ILE14G, ILE178O, ILE181O, LEU111O, LEU118O, LEU130O, LEU135O, LEU137O, LEU139O, LEU142O, LEU147O, LEU148O, LEU162G, LEU171O, LEU25G, LEU27G, LEU36G, LYS104G, LYS110O, LYS126O, LYS141O, LYS146O, LYS179O, LYS22G, LYS23G, LYS40G, MET116O, MET133O, MET66O, MET99G, PHE121O, PHE15G, PHE165G, PHE18G, PRO117O, PRO17G, PRO29G, PRO32G, SER113O, SER119O, SER138O, SER152O, SER182O, SER35G, SER47O, SER60O, THR143O, THR155O, THR168G, THR168O, THR30G, TYR101G, TYR170O, TYR184O, TYR41G, TYR57O, TYR61O, TYR63O, VAL115O, VAL160G, VAL166O, VAL175O, VAL185O, VAL21G, VAL28G, VAL31G, VAL55O, VAL59O, VAL62O
• G-X: ILE14X, SER113G
• H-I: ALA129H, ALA186I, ALA68H, ALA76H, ALA81H, ARG180I, ARG189I, ARG190I, ARG72H, ARG78H, ASN74H, ASP128H, ASP201H, ASP201I, ASP71H, ASP73H, GLN187I, GLN202H, GLN202I, GLU183I, GLU207I, GLY127H, GLY192H, GLY192I, GLY194H, GLY194I, GLY196H, GLY196I, HIS195H, HIS195I, HIS199H, HIS199I, HIS206H, HIS206I, ILE178I, ILE181I, LEU130H, LEU137I, LEU188H, LEU188I, LEU204I, LEU205H, LEU77H, LEU80H, LYS141I, LYS179I, LYS193H, LYS193I, MET203H, MET203I, PHE200H, PHE200I, PHE67H, PHE70H, SER182I, TRP198H, TRP198I, TYR184I, TYR69H, VAL185I, VAL191I, VAL197H, VAL197I, VAL75H
• H-W: ILE14W, MET116H
• H-X: ALA132X, ALA136X, ALA163H, ALA163X, ALA177X, ALA186X, ALA34H, ALA37H, ALA65X, ARG105H, ARG180X, ARG189X, ARG190X, ARG38H, ASN103H, ASN144X, ASN149X, ASN54X, ASN58X, ASP120X, ASP159H, ASP164H, ASP164X, ASP26H, GLN102H, GLN112X, GLN161H, GLN174X, GLN187X, GLN39H, GLN52X, GLU100H, GLU134X, GLU140X, GLU145X, GLU167H, GLU167X, GLU169X, GLU16H, GLU173X, GLU176X, GLU183X, GLU19H, GLU20H, GLU24H, GLU51X, GLU56X, GLY106H, GLY158H, GLY172X, HIS123X, HIS131X, HIS151H, HIS151X, ILE114X, ILE178X, ILE181X, LEU118X, LEU130X, LEU135X, LEU137X, LEU139X, LEU142X, LEU147X, LEU148X, LEU162H, LEU171X, LEU25H, LEU27H, LEU36H, LYS104H, LYS126X, LYS141X, LYS146X, LYS179X, LYS22H, LYS23H, LYS40H, MET116X, MET133X, MET66X, MET99H, PHE121X, PHE15H, PHE165H, PHE18H, PRO117X, PRO17H, PRO29H, PRO32H, SER113X, SER119X, SER138X, SER152X, SER182X, SER35H, SER60X, THR143X, THR155H, THR155X, THR168H, THR168X, THR30H, TYR101H, TYR170X, TYR184X, TYR41H, TYR57X, TYR61X, TYR63X, VAL115X, VAL160H, VAL166X, VAL175X, VAL185X, VAL21H, VAL28H, VAL31H, VAL55X, VAL59X, VAL62X
• I-W: ALA132W, ALA136W, ALA163I, ALA163W, ALA177W, ALA186W, ALA34I, ALA37I, ALA65W, ARG105I, ARG180W, ARG189W, ARG190W, ARG38I, ASN103I, ASN144W, ASN149W, ASN50W, ASN54W, ASN58W, ASP120W, ASP159I, ASP164I, ASP164W, ASP26I, GLN102I, GLN112W, GLN161I, GLN174W, GLN187W, GLN39I, GLN52W, GLU100I, GLU134W, GLU140W, GLU145W, GLU167I, GLU167W, GLU169W, GLU16I, GLU173W, GLU176W, GLU183W, GLU19I, GLU20I, GLU24I, GLU51W, GLU56W, GLY106I, GLY158I, GLY172W, HIS123W, HIS131W, HIS151W, ILE114W, ILE14I, ILE178W, ILE181W, LEU118W, LEU130W, LEU135W, LEU137W, LEU139W, LEU142W, LEU147W, LEU148W, LEU162I, LEU171W, LEU25I, LEU27I, LEU36I, LYS104I, LYS126W, LYS141W, LYS146W, LYS179W, LYS22I, LYS23I, LYS40I, MET116W, MET133W, MET66W, MET99I, PHE121W, PHE15I, PHE165I, PHE18I, PRO117W, PRO17I, PRO29I, PRO32I, SER113W, SER119W, SER138W, SER152W, SER182W, SER35I, SER47W, SER60W, THR143W, THR155W, THR168I, THR168W, THR30I, TYR101I, TYR170W, TYR184W, TYR41I, TYR57W, TYR61W, TYR63W, VAL115W, VAL160I, VAL166W, VAL175W, VAL185W, VAL21I, VAL28I, VAL31I, VAL55W, VAL59W, VAL62W
• J-N: ALA132J, ALA136J, ALA163J, ALA163N, ALA177J, ALA186J, ALA34N, ALA37N, ALA65J, ARG105N, ARG180J, ARG189J, ARG190J, ARG38N, ASN103N, ASN144J, ASN149J, ASN50J, ASN54J, ASN58J, ASP159N, ASP164J, ASP164N, ASP26N, GLN102N, GLN112J, GLN161N, GLN174J, GLN187J, GLN39N, GLN52J, GLU100N, GLU134J, GLU140J, GLU145J, GLU167J, GLU167N, GLU169J, GLU16N, GLU173J, GLU176J, GLU183J, GLU19N, GLU20N, GLU24N, GLU51J, GLU56J, GLY106N, GLY158N, GLY172J, HIS123J, HIS131J, HIS151J, HIS151N, ILE114J, ILE14N, ILE178J, ILE181J, LEU118J, LEU130J, LEU135J, LEU137J, LEU139J, LEU142J, LEU147J, LEU148J, LEU162N, LEU171J, LEU25N, LEU27N, LEU36N, LYS104N, LYS126J, LYS141J, LYS146J, LYS179J, LYS22N, LYS23N, LYS40N, MET116J, MET133J, MET66J, MET99N, PHE121J, PHE15N, PHE165N, PHE18N, PRO117J, PRO17N, PRO29N, PRO32N, SER113J, SER119J, SER138J, SER152J, SER182J, SER35N, SER47J, SER60J, THR143J, THR155J, THR168J, THR168N, THR30N, TYR101N, TYR170J, TYR184J, TYR41N, TYR57J, TYR61J, TYR63J, VAL115J, VAL160N, VAL166J, VAL175J, VAL185J, VAL21N, VAL28N, VAL31N, VAL55J, VAL59J, VAL62J
• J-O: GLY196J, GLY196O, HIS195J, HIS195O, HIS199J, HIS199O, TRP198J, TRP198O, VAL191J, VAL191O
• J-Q: ALA132Q, ALA136Q, ALA163J, ALA163Q, ALA177Q, ALA186Q, ALA34J, ALA37J, ALA65Q, ARG105J, ARG180Q, ARG189Q, ARG190Q, ARG38J, ASN103J, ASN144Q, ASN149Q, ASN50Q, ASN54Q, ASN58Q, ASP120Q, ASP159J, ASP164J, ASP164Q, ASP26J, GLN102J, GLN112Q, GLN161J, GLN174Q, GLN187Q, GLN39J, GLN52Q, GLU100J, GLU134Q, GLU140Q, GLU145Q, GLU167J, GLU167Q, GLU169Q, GLU16J, GLU173Q, GLU176Q, GLU183Q, GLU19J, GLU20J, GLU24J, GLU51Q, GLU56Q, GLY106J, GLY158J, GLY172Q, HIS123Q, HIS131Q, HIS151Q, ILE114Q, ILE14J, ILE178Q, ILE181Q, ILE53Q, LEU118Q, LEU130Q, LEU135Q, LEU137Q, LEU139Q, LEU142Q, LEU147Q, LEU148Q, LEU162J, LEU171Q, LEU25J, LEU27J, LEU36J, LYS104J, LYS126Q, LYS141Q, LYS146Q, LYS179Q, LYS22J, LYS23J, LYS40J, MET116Q, MET133Q, MET66Q, MET99J, PHE121Q, PHE15J, PHE165J, PHE18J, PRO117Q, PRO17J, PRO29J, PRO32J, SER113Q, SER119Q, SER138Q, SER152Q, SER182Q, SER35J, SER47Q, SER60Q, THR143Q, THR155Q, THR168J, THR168Q, THR30J, TYR101J, TYR170Q, TYR184Q, TYR41J, TYR57Q, TYR61Q, TYR63Q, VAL115Q, VAL160J, VAL166Q, VAL175Q, VAL185Q, VAL21J, VAL28J, VAL31J, VAL55Q, VAL59Q, VAL62Q
• J-R: ALA129R, ALA186J, ALA68R, ALA76R, ALA81R, ARG180J, ARG189J, ARG190J, ARG72R, ARG78R, ASN74R, ASP128R, ASP201J, ASP201R, ASP71R, ASP73R, GLN187J, GLN202J, GLN202R, GLU183J, GLU207J, GLY127R, GLY192J, GLY192R, GLY194J, GLY194R, GLY196J, GLY196R, HIS195J, HIS195R, HIS199J, HIS199R, HIS206J, HIS206R, ILE178J, ILE181J, LEU130R, LEU137J, LEU188J, LEU188R, LEU204J, LEU205R, LEU77R, LEU80R, LYS141J, LYS179J, LYS193J, LYS193R, MET203J, MET203R, PHE200J, PHE200R, PHE67R, PHE70R, SER182J, TRP198J, TRP198R, TYR184J, TYR69R, VAL185J, VAL191J, VAL197J, VAL197R, VAL75R
• J-X: ALA124J, ALA124X, ALA34J, ALA34X, ALA37J, ALA37X, ALA65J, ALA65X, ALA68J, ALA68X, ALA76J, ALA76X, ALA81J, ALA81X, ALA95J, ALA95X, ARG105J, ARG105X, ARG38J, ARG38X, ARG72J, ARG72X, ARG92J, ARG92X, ASN103J, ASN103X, ASN50J, ASN50X, ASN54J, ASN54X, ASN58J, ASN58X, ASN74J, ASN74X, ASP120J, ASP120X, ASP122J, ASP122X, ASP71J, ASP71X, ASP73J, ASP73X, GLN102J, GLN102X, GLN112J, GLN112X, GLN33J, GLN33X, GLU100J, GLU100X, GLU46J, GLU46X, GLU86J, GLU86X, GLU89J, GLU89X, GLU90J, GLU90X, GLU91J, GLU91X, GLU93J, GLU93X, GLU96J, GLU96X, GLY106J, GLY106X, GLY107J, GLY107X, HIS123J, HIS123X, HIS64J, HIS64X, ILE114J, ILE114X, ILE53J, ILE53X, LEU111J, LEU111X, LEU118J, LEU118X, LEU36J, LEU36X, LEU98J, LEU98X, LYS104J, LYS104X, LYS108J, LYS108X, LYS110J, LYS110X, LYS85J, LYS85X, LYS97J, LYS97X, MET116J, MET116X, MET66J, MET66X, MET99J, MET99X, PHE121J, PHE121X, PHE67J, PHE67X, PHE70J, PHE70X, PHE84J, PHE84X, PRO117J, PRO117X, PRO29J, PRO29X, PRO32J, PRO32X, SER113J, SER113X, SER119J, SER119X, SER35J, SER35X, SER60J, SER60X, SER87J, SER87X, SER88J, SER88X, TYR101J, TYR101X, TYR57J, TYR57X, TYR61J, TYR61X, TYR63J, TYR63X, TYR69J, TYR69X, VAL109J, VAL109X, VAL115J, VAL115X, VAL31J, VAL31X, VAL62J, VAL62X, VAL75J, VAL75X
• K-P: ALA132P, ALA136P, ALA163K, ALA163P, ALA177P, ALA186P, ALA34K, ALA37K, ALA65P, ARG105K, ARG180P, ARG189P, ARG190P, ARG38K, ASN103K, ASN144P, ASN149P, ASN50P, ASN54P, ASN58P, ASP120P, ASP159K, ASP164K, ASP164P, ASP26K, GLN102K, GLN112P, GLN161K, GLN174P, GLN187P, GLN33K, GLN39K, GLN52P, GLU100K, GLU134P, GLU140P, GLU145P, GLU167K, GLU167P, GLU169P, GLU16K, GLU173P, GLU176P, GLU183P, GLU19K, GLU20K, GLU24K, GLU51P, GLU56P, GLY106K, GLY158K, GLY172P, HIS123P, HIS131P, HIS151K, HIS151P, ILE114P, ILE14K, ILE178P, ILE181P, LEU118P, LEU130P, LEU135P, LEU137P, LEU139P, LEU142P, LEU147P, LEU148P, LEU162K, LEU171P, LEU25K, LEU27K, LEU36K, LYS104K, LYS126P, LYS141P, LYS146P, LYS179P, LYS22K, LYS23K, LYS40K, MET116P, MET133P, MET66P, MET99K, PHE121P, PHE15K, PHE165K, PHE18K, PRO117P, PRO17K, PRO29K, PRO32K, SER113P, SER119P, SER138P, SER152P, SER182P, SER35K, SER47P, SER60P, THR143P, THR155P, THR168K, THR168P, THR30K, TYR101K, TYR170P, TYR184P, TYR41K, TYR57P, TYR61P, TYR63P, VAL115P, VAL160K, VAL166P, VAL175P, VAL185P, VAL21K, VAL28K, VAL31K, VAL55P, VAL59P, VAL62P
• K-Q: ALA129Q, ALA186K, ALA68Q, ALA76Q, ALA81Q, ARG180K, ARG189K, ARG190K, ARG72Q, ARG78Q, ASN74Q, ASP122Q, ASP128Q, ASP201K, ASP201Q, ASP71Q, ASP73Q, GLN187K, GLN202K, GLN202Q, GLU183K, GLU207K, GLY127Q, GLY192K, GLY192Q, GLY194K, GLY194Q, GLY196K, GLY196Q, HIS195K, HIS195Q, HIS199K, HIS199Q, HIS206K, HIS206Q, ILE178K, ILE181K, LEU130Q, LEU137K, LEU188K, LEU188Q, LEU204K, LEU205Q, LEU77Q, LEU80Q, LYS141K, LYS179K, LYS193K, LYS193Q, MET203K, MET203Q, PHE200K, PHE200Q, PHE67Q, PHE70Q, SER182K, TRP198K, TRP198Q, TYR184K, TYR69Q, VAL185K, VAL191K, VAL197K, VAL197Q, VAL75Q
• K-U: ALA132K, ALA136K, ALA163K, ALA163U, ALA177K, ALA186K, ALA34U, ALA37U, ALA65K, ARG105U, ARG180K, ARG189K, ARG190K, ARG38U, ASN103U, ASN144K, ASN149K, ASN50K, ASN54K, ASN58K, ASP120K, ASP159U, ASP164K, ASP164U, ASP26U, GLN102U, GLN112K, GLN161U, GLN174K, GLN187K, GLN39U, GLN52K, GLU100U, GLU134K, GLU140K, GLU145K, GLU167K, GLU167U, GLU169K, GLU16U, GLU173K, GLU176K, GLU183K, GLU19U, GLU20U, GLU24U, GLU51K, GLU56K, GLY106U, GLY158U, GLY172K, HIS123K, HIS131K, HIS151K, HIS151U, ILE114K, ILE14U, ILE178K, ILE181K, LEU118K, LEU130K, LEU135K, LEU137K, LEU139K, LEU142K, LEU147K, LEU148K, LEU162U, LEU171K, LEU25U, LEU27U, LEU36U, LYS104U, LYS110K, LYS126K, LYS141K, LYS146K, LYS179K, LYS22U, LYS23U, LYS40U, MET116K, MET133K, MET66K, MET99U, PHE121K, PHE15U, PHE165U, PHE18U, PRO117K, PRO17U, PRO29U, PRO32U, SER113K, SER119K, SER138K, SER152K, SER182K, SER35U, SER47K, SER60K, THR143K, THR155K, THR168K, THR168U, THR30U, TYR101U, TYR170K, TYR184K, TYR41U, TYR57K, TYR61K, TYR63K, VAL115K, VAL160U, VAL166K, VAL175K, VAL185K, VAL21U, VAL28U, VAL31U, VAL55K, VAL59K, VAL62K
• K-W: ALA124K, ALA124W, ALA34K, ALA34W, ALA37K, ALA37W, ALA65K, ALA65W, ALA68K, ALA68W, ALA76K, ALA76W, ALA81K, ALA81W, ALA95K, ALA95W, ARG105K, ARG105W, ARG38K, ARG38W, ARG72K, ARG72W, ARG92K, ARG92W, ASN103K, ASN103W, ASN50K, ASN50W, ASN54K, ASN54W, ASN58K, ASN58W, ASN74K, ASN74W, ASP120K, ASP120W, ASP122K, ASP122W, ASP128W, ASP71K, ASP71W, ASP73K, ASP73W, GLN102K, GLN102W, GLN112K, GLN112W, GLN33K, GLN33W, GLU100K, GLU100W, GLU46K, GLU46W, GLU86K, GLU86W, GLU89K, GLU89W, GLU90K, GLU90W, GLU91K, GLU91W, GLU93K, GLU93W, GLU96K, GLU96W, GLY106K, GLY106W, GLY107K, GLY107W, HIS123W, HIS64K, HIS64W, ILE114K, ILE114W, ILE53K, ILE53W, LEU111K, LEU111W, LEU118K, LEU118W, LEU36K, LEU36W, LEU98K, LEU98W, LYS104K, LYS104W, LYS108K, LYS108W, LYS110K, LYS110W, LYS85K, LYS85W, LYS97K, LYS97W, MET116K, MET116W, MET66K, MET66W, MET99K, MET99W, PHE121K, PHE121W, PHE67K, PHE67W, PHE70K, PHE70W, PHE84K, PHE84W, PRO117K, PRO117W, PRO29K, PRO29W, PRO32K, PRO32W, SER113K, SER113W, SER119K, SER119W, SER35K, SER35W, SER60K, SER60W, SER87K, SER87W, SER88K, SER88W, TYR101K, TYR101W, TYR57K, TYR57W, TYR61K, TYR61W, TYR63K, TYR63W, TYR69K, TYR69W, VAL109K, VAL109W, VAL115K, VAL115W, VAL31K, VAL31W, VAL62K, VAL62W, VAL75K, VAL75W
• K-X: GLY196K, GLY196X, HIS195K, HIS195X, HIS199K, HIS199X, TRP198K, TRP198X, VAL191K, VAL191X
• L-M: ALA132M, ALA136M, ALA163L, ALA163M, ALA177M, ALA186M, ALA34L, ALA37L, ALA65M, ARG105L, ARG180M, ARG189M, ARG190M, ARG38L, ASN103L, ASN144M, ASN149M, ASN54M, ASN58M, ASP159L, ASP164L, ASP164M, ASP26L, GLN102L, GLN112M, GLN161L, GLN174M, GLN187M, GLN39L, GLU100L, GLU134M, GLU140M, GLU145M, GLU167L, GLU167M, GLU169M, GLU16L, GLU173M, GLU176M, GLU183M, GLU19L, GLU20L, GLU24L, GLU51M, GLU56M, GLY106L, GLY107L, GLY158L, GLY172M, HIS123M, HIS131M, HIS151L, HIS151M, ILE114M, ILE178M, ILE181M, LEU118M, LEU130M, LEU135M, LEU137M, LEU139M, LEU142M, LEU147M, LEU148M, LEU162L, LEU171M, LEU25L, LEU27L, LEU36L, LYS104L, LYS126M, LYS141M, LYS146M, LYS179M, LYS22L, LYS23L, LYS40L, MET116M, MET133M, MET66M, MET99L, PHE121M, PHE15L, PHE165L, PHE18L, PRO117M, PRO17L, PRO29L, PRO32L, SER113M, SER119M, SER138M, SER152M, SER182M, SER35L, SER60M, THR143M, THR155M, THR168L, THR168M, THR30L, TYR101L, TYR170M, TYR184M, TYR41L, TYR57M, TYR61M, TYR63M, VAL115M, VAL160L, VAL166M, VAL175M, VAL185M, VAL21L, VAL28L, VAL31L, VAL55M, VAL59M, VAL62M
• L-P: ALA129P, ALA186L, ALA68P, ALA76P, ALA81P, ARG180L, ARG189L, ARG190L, ARG72P, ARG78P, ASN74P, ASP128P, ASP201L, ASP201P, ASP71P, ASP73P, GLN187L, GLN202L, GLN202P, GLU183L, GLU207L, GLY127P, GLY192L, GLY192P, GLY194L, GLY194P, GLY196L, GLY196P, HIS195L, HIS195P, HIS199L, HIS199P, HIS206L, HIS206P, ILE178L, ILE181L, LEU130P, LEU137L, LEU188L, LEU188P, LEU204L, LEU205P, LEU77P, LEU80P, LYS141L, LYS179L, LYS193L, LYS193P, MET203L, MET203P, PHE200L, PHE200P, PHE67P, PHE70P, SER182L, TRP198L, TRP198P, TYR184L, TYR69P, VAL185L, VAL191L, VAL197L, VAL197P, VAL75P
• L-S: GLU16L, SER113S
• L-T: ALA132L, ALA136L, ALA163L, ALA163T, ALA177L, ALA186L, ALA34T, ALA37T, ALA65L, ARG105T, ARG180L, ARG189L, ARG190L, ARG38T, ASN103T, ASN144L, ASN149L, ASN54L, ASN58L, ASP120L, ASP159T, ASP164L, ASP164T, ASP26T, GLN102T, GLN112L, GLN161T, GLN174L, GLN187L, GLN39T, GLN52L, GLU100T, GLU134L, GLU140L, GLU145L, GLU167L, GLU167T, GLU16T, GLU173L, GLU176L, GLU183L, GLU19T, GLU20T, GLU24T, GLU51L, GLU56L, GLY106T, GLY158T, GLY172L, HIS123L, HIS131L, HIS151L, ILE114L, ILE14T, ILE178L, ILE181L, LEU118L, LEU130L, LEU135L, LEU137L, LEU139L, LEU142L, LEU147L, LEU148L, LEU162T, LEU171L, LEU25T, LEU27T, LEU36T, LYS104T, LYS126L, LYS141L, LYS146L, LYS179L, LYS22T, LYS23T, LYS40T, MET116L, MET133L, MET66L, MET99T, PHE121L, PHE15T, PHE165T, PHE18T, PRO117L, PRO17T, PRO29T, PRO32T, SER113L, SER119L, SER138L, SER152L, SER182L, SER35T, SER60L, THR143L, THR155L, THR155T, THR168L, THR168T, THR30T, TYR101T, TYR170L, TYR184L, TYR41T, TYR57L, TYR61L, TYR63L, VAL115L, VAL160T, VAL166L, VAL175L, VAL185L, VAL21T, VAL28T, VAL31T, VAL55L, VAL59L, VAL62L
• L-V: ALA124L, ALA34L, ALA34V, ALA37L, ALA37V, ALA65L, ALA65V, ALA68L, ALA68V, ALA76L, ALA76V, ALA81L, ALA81V, ALA95L, ALA95V, ARG105L, ARG105V, ARG38L, ARG38V, ARG72L, ARG72V, ARG92L, ARG92V, ASN103L, ASN103V, ASN50L, ASN50V, ASN54L, ASN54V, ASN58L, ASN58V, ASN74L, ASN74V, ASP120L, ASP120V, ASP122L, ASP122V, ASP128L, ASP71L, ASP71V, ASP73L, ASP73V, GLN102L, GLN102V, GLN112L, GLN112V, GLN33L, GLN33V, GLU100L, GLU100V, GLU46L, GLU46V, GLU86L, GLU86V, GLU89L, GLU89V, GLU90L, GLU90V, GLU91L, GLU91V, GLU93L, GLU93V, GLU96L, GLU96V, GLY106L, GLY106V, GLY107L, GLY107V, HIS123L, HIS64L, HIS64V, ILE114L, ILE114V, ILE53L, ILE53V, LEU111L, LEU111V, LEU118L, LEU118V, LEU36L, LEU36V, LEU98L, LEU98V, LYS104L, LYS104V, LYS108L, LYS108V, LYS110L, LYS110V, LYS85L, LYS85V, LYS97L, LYS97V, MET116L, MET116V, MET66L, MET66V, MET99L, MET99V, PHE121L, PHE121V, PHE67L, PHE67V, PHE70L, PHE70V, PHE84L, PHE84V, PRO117L, PRO117V, PRO29L, PRO29V, PRO32L, PRO32V, SER113L, SER113V, SER119L, SER119V, SER35L, SER35V, SER60L, SER60V, SER87L, SER87V, SER88L, SER88V, TYR101L, TYR101V, TYR57L, TYR57V, TYR61L, TYR61V, TYR63L, TYR63V, TYR69L, TYR69V, VAL109L, VAL109V, VAL115L, VAL115V, VAL31L, VAL31V, VAL62L, VAL62V, VAL75L, VAL75V
• L-W: GLY196L, GLY196W, HIS195L, HIS195W, HIS199L, HIS199W, TRP198L, TRP198W, VAL191L, VAL191W
• M-P: ILE14M, MET116P
• M-R: GLY12R, ILE114M, ILE14R, MET116M, PRO117M, SER113M, VAL115M, VAL13R
• M-S: ALA124M, ALA34M, ALA34S, ALA37M, ALA37S, ALA65M, ALA65S, ALA68M, ALA68S, ALA76M, ALA76S, ALA81M, ALA81S, ALA95M, ALA95S, ARG105M, ARG105S, ARG38M, ARG38S, ARG72M, ARG72S, ARG92M, ARG92S, ASN103M, ASN103S, ASN50M, ASN50S, ASN54M, ASN54S, ASN58M, ASN58S, ASN74M, ASN74S, ASP120M, ASP120S, ASP122M, ASP122S, ASP128M, ASP128S, ASP71M, ASP71S, ASP73M, ASP73S, GLN102M, GLN102S, GLN112M, GLN112S, GLN33M, GLN33S, GLU100M, GLU100S, GLU46M, GLU46S, GLU86M, GLU86S, GLU89M, GLU89S, GLU90M, GLU90S, GLU91M, GLU91S, GLU93M, GLU93S, GLU96M, GLU96S, GLY106M, GLY106S, GLY107M, GLY107S, HIS123M, HIS123S, HIS64M, HIS64S, ILE114M, ILE114S, ILE53M, ILE53S, LEU111M, LEU111S, LEU118M, LEU118S, LEU36M, LEU36S, LEU98M, LEU98S, LYS104M, LYS104S, LYS108M, LYS108S, LYS110M, LYS110S, LYS85M, LYS85S, LYS97M, LYS97S, MET116M, MET116S, MET66M, MET66S, MET99M, MET99S, PHE121M, PHE121S, PHE67M, PHE67S, PHE70M, PHE70S, PHE84M, PHE84S, PRO117M, PRO117S, PRO29M, PRO29S, PRO32M, PRO32S, SER113M, SER113S, SER119M, SER119S, SER35M, SER35S, SER60M, SER60S, SER87M, SER87S, SER88M, SER88S, TYR101M, TYR101S, TYR57M, TYR57S, TYR61M, TYR61S, TYR63M, TYR63S, TYR69M, TYR69S, VAL109M, VAL109S, VAL115M, VAL115S, VAL31M, VAL31S, VAL62M, VAL62S, VAL75M, VAL75S
• M-T: ALA132T, ALA136T, ALA163M, ALA163T, ALA177T, ALA186T, ALA34M, ALA37M, ALA65T, ARG105M, ARG180T, ARG189T, ARG190T, ARG38M, ASN103M, ASN144T, ASN149T, ASN54T, ASN58T, ASP120T, ASP159M, ASP164M, ASP164T, ASP26M, GLN102M, GLN112T, GLN161M, GLN174T, GLN187T, GLN39M, GLU100M, GLU134T, GLU140T, GLU145T, GLU167M, GLU167T, GLU169T, GLU16M, GLU173T, GLU176T, GLU183T, GLU19M, GLU20M, GLU24M, GLU51T, GLU56T, GLY106M, GLY158M, GLY172T, HIS123T, HIS131T, HIS151M, HIS151T, ILE114T, ILE14M, ILE178T, ILE181T, LEU118T, LEU130T, LEU135T, LEU137T, LEU139T, LEU142T, LEU147T, LEU148T, LEU162M, LEU171T, LEU25M, LEU27M, LEU36M, LYS104M, LYS126T, LYS141T, LYS146T, LYS179T, LYS22M, LYS23M, LYS40M, MET116T, MET133T, MET66T, MET99M, PHE121T, PHE15M, PHE165M, PHE18M, PRO117T, PRO17M, PRO29M, PRO32M, SER113T, SER119T, SER138T, SER152T, SER182T, SER35M, SER60T, THR143T, THR155M, THR155T, THR168M, THR168T, THR30M, TYR101M, TYR170T, TYR184T, TYR41M, TYR57T, TYR61T, TYR63T, VAL115T, VAL160M, VAL166T, VAL175T, VAL185T, VAL21M, VAL28M, VAL31M, VAL55T, VAL59T, VAL62T
• M-V: ALA129V, ALA186M, ALA68V, ALA76V, ALA81V, ARG180M, ARG189M, ARG190M, ARG72V, ARG78V, ASN74V, ASP128V, ASP201M, ASP201V, ASP71V, ASP73V, GLN187M, GLN202M, GLN202V, GLU183M, GLU207M, GLY127V, GLY192M, GLY192V, GLY194M, GLY194V, GLY196M, GLY196V, HIS195M, HIS195V, HIS199M, HIS199V, HIS206M, HIS206V, ILE178M, ILE181M, LEU130V, LEU137M, LEU188M, LEU188V, LEU204M, LEU205V, LEU77V, LEU80V, LYS141M, LYS179M, LYS193M, LYS193V, MET203M, MET203V, PHE200M, PHE200V, PHE67V, PHE70V, SER182M, TRP198M, TRP198V, TYR184M, TYR69V, VAL185M, VAL191M, VAL197M, VAL197V, VAL75V
• N-Q: ALA132N, ALA136N, ALA163N, ALA163Q, ALA177N, ALA186N, ALA34Q, ALA37Q, ALA65N, ARG105Q, ARG180N, ARG189N, ARG190N, ARG38Q, ASN103Q, ASN144N, ASN149N, ASN50N, ASN54N, ASN58N, ASP120N, ASP159Q, ASP164N, ASP164Q, ASP26Q, GLN102Q, GLN112N, GLN161Q, GLN174N, GLN187N, GLN39Q, GLN52N, GLU100Q, GLU134N, GLU140N, GLU145N, GLU167N, GLU167Q, GLU169N, GLU16Q, GLU173N, GLU176N, GLU183N, GLU19Q, GLU20Q, GLU24Q, GLU51N, GLU56N, GLY106Q, GLY158Q, GLY172N, HIS123N, HIS131N, HIS151N, HIS151Q, ILE114N, ILE14Q, ILE178N, ILE181N, LEU118N, LEU130N, LEU135N, LEU137N, LEU139N, LEU142N, LEU147N, LEU148N, LEU162Q, LEU171N, LEU25Q, LEU27Q, LEU36Q, LYS104Q, LYS110N, LYS126N, LYS141N, LYS146N, LYS179N, LYS22Q, LYS23Q, LYS40Q, MET116N, MET133N, MET66N, MET99Q, PHE121N, PHE15Q, PHE165Q, PHE18Q, PRO117N, PRO17Q, PRO29Q, PRO32Q, SER113N, SER119N, SER138N, SER152N, SER182N, SER35Q, SER47N, SER60N, THR143N, THR155N, THR155Q, THR168N, THR168Q, THR30Q, TYR101Q, TYR170N, TYR184N, TYR41Q, TYR57N, TYR61N, TYR63N, VAL115N, VAL160Q, VAL166N, VAL175N, VAL185N, VAL21Q, VAL28Q, VAL31Q, VAL55N, VAL59N, VAL62N
• N-R: ALA124N, ALA124R, ALA34N, ALA34R, ALA37N, ALA37R, ALA65N, ALA65R, ALA68N, ALA68R, ALA76N, ALA76R, ALA81N, ALA81R, ALA95N, ALA95R, ARG105N, ARG105R, ARG38N, ARG38R, ARG72N, ARG72R, ARG92N, ARG92R, ASN103N, ASN103R, ASN50N, ASN50R, ASN54N, ASN54R, ASN58N, ASN58R, ASN74N, ASN74R, ASP120N, ASP120R, ASP122N, ASP122R, ASP128R, ASP71N, ASP71R, ASP73N, ASP73R, GLN102N, GLN102R, GLN112N, GLN112R, GLN33N, GLN33R, GLU100N, GLU100R, GLU46N, GLU46R, GLU86N, GLU86R, GLU89N, GLU89R, GLU90N, GLU90R, GLU91N, GLU91R, GLU93N, GLU93R, GLU96N, GLU96R, GLY106N, GLY106R, GLY107N, GLY107R, HIS123N, HIS64N, HIS64R, ILE114N, ILE114R, ILE53N, ILE53R, LEU111N, LEU111R, LEU118N, LEU118R, LEU36N, LEU36R, LEU98N, LEU98R, LYS104N, LYS104R, LYS108N, LYS108R, LYS110N, LYS110R, LYS85N, LYS85R, LYS97N, LYS97R, MET116N, MET116R, MET66N, MET66R, MET99N, MET99R, PHE121N, PHE121R, PHE67N, PHE67R, PHE70N, PHE70R, PHE84N, PHE84R, PRO117N, PRO117R, PRO29N, PRO29R, PRO32N, PRO32R, SER113N, SER113R, SER119N, SER119R, SER35N, SER35R, SER60N, SER60R, SER87N, SER87R, SER88N, SER88R, TYR101N, TYR101R, TYR57N, TYR57R, TYR61N, TYR61R, TYR63N, TYR63R, TYR69N, TYR69R, VAL109N, VAL109R, VAL115N, VAL115R, VAL31N, VAL31R, VAL62N, VAL62R, VAL75N, VAL75R
• N-S: ALA129N, ALA186S, ALA68N, ALA76N, ALA81N, ARG180S, ARG189S, ARG190S, ARG72N, ARG78N, ASN74N, ASP122N, ASP128N, ASP201N, ASP201S, ASP71N, ASP73N, GLN187S, GLN202N, GLN202S, GLU183S, GLU207S, GLY127N, GLY192N, GLY192S, GLY194N, GLY194S, GLY196N, GLY196S, HIS195N, HIS195S, HIS199N, HIS199S, HIS206N, HIS206S, ILE178S, ILE181S, LEU130N, LEU137S, LEU188N, LEU188S, LEU204S, LEU205N, LEU77N, LEU80N, LYS141S, LYS179S, LYS193N, LYS193S, MET203N, MET203S, PHE200N, PHE200S, PHE67N, PHE70N, SER182S, TRP198N, TRP198S, TYR184S, TYR69N, VAL185S, VAL191S, VAL197N, VAL197S, VAL75N
• N-T: GLY196N, GLY196T, HIS195N, HIS195T, HIS199N, HIS199T, TRP198N, TRP198T, VAL191N, VAL191T
• N-U: ALA129U, ALA186N, ALA68U, ALA76U, ALA81U, ARG180N, ARG189N, ARG190N, ARG72U, ARG78U, ASN74U, ASP122U, ASP128U, ASP201N, ASP201U, ASP71U, ASP73U, GLN187N, GLN202N, GLN202U, GLU183N, GLU207N, GLY127U, GLY192N, GLY192U, GLY194N, GLY194U, GLY196N, GLY196U, HIS195N, HIS195U, HIS199N, HIS199U, HIS206N, HIS206U, ILE178N, ILE181N, LEU130U, LEU137N, LEU188N, LEU188U, LEU204N, LEU205U, LEU77U, LEU80U, LYS141N, LYS179N, LYS193N, LYS193U, MET203N, MET203U, PHE200N, PHE200U, PHE67U, PHE70U, SER182N, TRP198N, TRP198U, TYR184N, TYR69U, VAL185N, VAL191N, VAL197N, VAL197U, VAL75U
• O-R: ALA129O, ALA186R, ALA68O, ALA76O, ALA81O, ARG180R, ARG189R, ARG190R, ARG72O, ARG78O, ASN74O, ASP122O, ASP128O, ASP201O, ASP201R, ASP71O, ASP73O, GLN187R, GLN202O, GLN202R, GLU183R, GLU207R, GLY127O, GLY192O, GLY192R, GLY194O, GLY194R, GLY196O, GLY196R, HIS195O, HIS195R, HIS199O, HIS199R, HIS206O, HIS206R, ILE178R, ILE181R, LEU130O, LEU137R, LEU188O, LEU188R, LEU204R, LEU205O, LEU77O, LEU80O, LYS141R, LYS179R, LYS193O, LYS193R, MET203O, MET203R, PHE200O, PHE200R, PHE67O, PHE70O, SER182R, TRP198O, TRP198R, TYR184R, TYR69O, VAL185R, VAL191R, VAL197O, VAL197R, VAL75O
• P-T: ALA124P, ALA34P, ALA34T, ALA37P, ALA37T, ALA65P, ALA65T, ALA68P, ALA68T, ALA76P, ALA76T, ALA81P, ALA81T, ALA95P, ALA95T, ARG105P, ARG105T, ARG38P, ARG38T, ARG72P, ARG72T, ARG92P, ARG92T, ASN103P, ASN103T, ASN50P, ASN50T, ASN54P, ASN54T, ASN58P, ASN58T, ASN74P, ASN74T, ASP120P, ASP120T, ASP122P, ASP122T, ASP128P, ASP71P, ASP71T, ASP73P, ASP73T, GLN102P, GLN102T, GLN112P, GLN112T, GLN33P, GLN33T, GLU100P, GLU100T, GLU46P, GLU46T, GLU86P, GLU86T, GLU89P, GLU89T, GLU90P, GLU90T, GLU91P, GLU91T, GLU93P, GLU93T, GLU96P, GLU96T, GLY106P, GLY106T, GLY107P, GLY107T, HIS123P, HIS64P, HIS64T, ILE114P, ILE114T, ILE53P, ILE53T, LEU111P, LEU111T, LEU118P, LEU118T, LEU36P, LEU36T, LEU98P, LEU98T, LYS104P, LYS104T, LYS108P, LYS108T, LYS110P, LYS110T, LYS85P, LYS85T, LYS97P, LYS97T, MET116P, MET116T, MET66P, MET66T, MET99P, MET99T, PHE121P, PHE121T, PHE67P, PHE67T, PHE70P, PHE70T, PHE84P, PHE84T, PRO117P, PRO117T, PRO29P, PRO29T, PRO32P, PRO32T, SER113P, SER113T, SER119P, SER119T, SER35P, SER35T, SER60P, SER60T, SER87P, SER87T, SER88P, SER88T, TYR101P, TYR101T, TYR57P, TYR57T, TYR61P, TYR61T, TYR63P, TYR63T, TYR69P, TYR69T, VAL109P, VAL109T, VAL115P, VAL115T, VAL31P, VAL31T, VAL62P, VAL62T, VAL75P, VAL75T
• P-U: ALA132U, ALA136U, ALA163P, ALA163U, ALA177U, ALA186U, ALA34P, ALA37P, ALA65U, ARG105P, ARG180U, ARG189U, ARG190U, ARG38P, ASN103P, ASN144U, ASN149U, ASN54U, ASN58U, ASP120U, ASP159P, ASP164P, ASP164U, ASP26P, GLN102P, GLN112U, GLN161P, GLN174U, GLN187U, GLN39P, GLN52U, GLU100P, GLU134U, GLU140U, GLU145U, GLU167P, GLU167U, GLU169U, GLU16P, GLU173U, GLU176U, GLU183U, GLU19P, GLU20P, GLU24P, GLU51U, GLU56U, GLY106P, GLY107P, GLY158P, GLY172U, HIS123U, HIS131U, HIS151U, ILE114U, ILE14P, ILE178U, ILE181U, LEU118U, LEU130U, LEU135U, LEU137U, LEU139U, LEU142U, LEU147U, LEU148U, LEU162P, LEU171U, LEU25P, LEU27P, LEU36P, LYS104P, LYS126U, LYS141U, LYS146U, LYS179U, LYS22P, LYS23P, LYS40P, MET116U, MET133U, MET66U, MET99P, PHE121U, PHE15P, PHE165P, PHE18P, PRO117U, PRO17P, PRO29P, PRO32P, SER113U, SER119U, SER138U, SER152U, SER182U, SER35P, SER60U, THR143U, THR155U, THR168P, THR168U, THR30P, TYR101P, TYR170U, TYR184U, TYR41P, TYR57U, TYR61U, TYR63U, VAL115U, VAL160P, VAL166U, VAL175U, VAL185U, VAL21P, VAL28P, VAL31P, VAL55U, VAL59U, VAL62U
• P-W: ALA129W, ALA186P, ALA68W, ALA76W, ALA81W, ARG180P, ARG189P, ARG190P, ARG72W, ARG78W, ASN74W, ASP128W, ASP201P, ASP201W, ASP71W, ASP73W, GLN187P, GLN202P, GLN202W, GLU183P, GLU207P, GLY127W, GLY192P, GLY192W, GLY194P, GLY194W, GLY196P, GLY196W, HIS195P, HIS195W, HIS199P, HIS199W, HIS206P, HIS206W, ILE178P, ILE181P, LEU130W, LEU137P, LEU188P, LEU188W, LEU204P, LEU205W, LEU77W, LEU80W, LYS141P, LYS179P, LYS193P, LYS193W, MET203P, MET203W, PHE200P, PHE200W, PHE67W, PHE70W, SER182P, TRP198P, TRP198W, TYR184P, TYR69W, VAL185P, VAL191P, VAL197P, VAL197W, VAL75W
• Q-U: ALA124Q, ALA34Q, ALA34U, ALA37Q, ALA37U, ALA65Q, ALA65U, ALA68Q, ALA68U, ALA76Q, ALA76U, ALA81Q, ALA81U, ALA95Q, ALA95U, ARG105Q, ARG105U, ARG38Q, ARG38U, ARG72Q, ARG72U, ARG92Q, ARG92U, ASN103Q, ASN103U, ASN50Q, ASN50U, ASN54Q, ASN54U, ASN58Q, ASN58U, ASN74Q, ASN74U, ASP120Q, ASP120U, ASP122Q, ASP122U, ASP128U, ASP71Q, ASP71U, ASP73Q, ASP73U, GLN102Q, GLN102U, GLN112Q, GLN112U, GLN33Q, GLN33U, GLU100Q, GLU100U, GLU46Q, GLU46U, GLU86Q, GLU86U, GLU89Q, GLU89U, GLU90Q, GLU90U, GLU91Q, GLU91U, GLU93Q, GLU93U, GLU96Q, GLU96U, GLY106Q, GLY106U, GLY107Q, GLY107U, HIS123Q, HIS64Q, HIS64U, ILE114Q, ILE114U, ILE53Q, ILE53U, LEU111Q, LEU111U, LEU118Q, LEU118U, LEU36Q, LEU36U, LEU98Q, LEU98U, LYS104Q, LYS104U, LYS108Q, LYS108U, LYS110Q, LYS110U, LYS85Q, LYS85U, LYS97Q, LYS97U, MET116Q, MET116U, MET66Q, MET66U, MET99Q, MET99U, PHE121Q, PHE121U, PHE67Q, PHE67U, PHE70Q, PHE70U, PHE84Q, PHE84U, PRO117Q, PRO117U, PRO29Q, PRO29U, PRO32Q, PRO32U, SER113Q, SER113U, SER119Q, SER119U, SER35Q, SER35U, SER60Q, SER60U, SER87Q, SER87U, SER88Q, SER88U, TYR101Q, TYR101U, TYR57Q, TYR57U, TYR61Q, TYR61U, TYR63Q, TYR63U, TYR69Q, TYR69U, VAL109Q, VAL109U, VAL115Q, VAL115U, VAL31Q, VAL31U, VAL62Q, VAL62U, VAL75Q, VAL75U
• Q-X: ALA129X, ALA186Q, ALA68X, ALA76X, ALA81X, ARG180Q, ARG189Q, ARG190Q, ARG72X, ARG78X, ASN74X, ASP122X, ASP128X, ASP201Q, ASP201X, ASP71X, ASP73X, GLN187Q, GLN202Q, GLN202X, GLU183Q, GLU207Q, GLY127X, GLY192Q, GLY192X, GLY194Q, GLY194X, GLY196Q, GLY196X, HIS195Q, HIS195X, HIS199Q, HIS199X, HIS206Q, HIS206X, ILE178Q, ILE181Q, LEU130X, LEU137Q, LEU188Q, LEU188X, LEU204Q, LEU205X, LEU77X, LEU80X, LYS141Q, LYS179Q, LYS193Q, LYS193X, MET203Q, MET203X, PHE200Q, PHE200X, PHE67X, PHE70X, SER182Q, TRP198Q, TRP198X, TYR184Q, TYR69X, VAL185Q, VAL191Q, VAL197Q, VAL197X, VAL75X
• R-S: ALA132S, ALA136S, ALA163R, ALA163S, ALA177S, ALA186S, ALA34R, ALA37R, ALA48S, ALA65S, ARG105R, ARG180S, ARG189S, ARG190S, ARG38R, ASN103R, ASN144S, ASN149S, ASN50S, ASN54S, ASN58S, ASP120S, ASP159R, ASP164R, ASP164S, ASP26R, GLN102R, GLN112S, GLN161R, GLN174S, GLN187S, GLN39R, GLN52S, GLU100R, GLU134S, GLU140S, GLU145S, GLU167R, GLU167S, GLU169S, GLU16R, GLU173S, GLU176S, GLU183S, GLU19R, GLU20R, GLU24R, GLU51S, GLU56S, GLY106R, GLY12R, GLY158R, GLY172S, HIS123S, HIS131S, HIS151S, ILE114S, ILE14R, ILE178S, ILE181S, ILE53S, LEU111S, LEU118S, LEU130S, LEU135S, LEU137S, LEU139S, LEU142S, LEU147S, LEU148S, LEU162R, LEU171S, LEU25R, LEU27R, LEU36R, LYS104R, LYS110S, LYS126S, LYS141S, LYS146S, LYS179S, LYS22R, LYS23R, LYS40R, MET116S, MET133S, MET66S, MET99R, PHE121S, PHE15R, PHE165R, PHE18R, PRO117S, PRO17R, PRO29R, PRO32R, SER113S, SER119S, SER138S, SER152S, SER182S, SER35R, SER47S, SER60S, THR143S, THR155S, THR168R, THR168S, THR30R, TYR101R, TYR170S, TYR184S, TYR41R, TYR57S, TYR61S, TYR63S, VAL115S, VAL13R, VAL160R, VAL166S, VAL175S, VAL185S, VAL21R, VAL28R, VAL31R, VAL55S, VAL59S, VAL62S
• S-T: ALA129S, ALA186T, ALA68S, ALA76S, ALA81S, ARG180T, ARG189T, ARG190T, ARG72S, ARG78S, ASN74S, ASP122S, ASP128S, ASP201S, ASP201T, ASP71S, ASP73S, GLN187T, GLN202S, GLN202T, GLU183T, GLU207T, GLY127S, GLY192S, GLY192T, GLY194S, GLY194T, GLY196S, GLY196T, HIS195S, HIS195T, HIS199S, HIS199T, HIS206S, HIS206T, ILE178T, ILE181T, LEU130S, LEU137T, LEU188S, LEU188T, LEU204T, LEU205S, LEU77S, LEU80S, LYS141T, LYS179T, LYS193S, LYS193T, MET203S, MET203T, PHE200S, PHE200T, PHE67S, PHE70S, SER182T, TRP198S, TRP198T, TYR184T, TYR69S, VAL185T, VAL191T, VAL197S, VAL197T, VAL75S
• S-U: GLY196S, GLY196U, HIS195S, HIS195U, HIS199S, HIS199U, TRP198S, TRP198U, VAL191S, VAL191U
• T-U: ALA129T, ALA186U, ALA68T, ALA76T, ALA81T, ARG180U, ARG189U, ARG190U, ARG72T, ARG78T, ASN74T, ASP122T, ASP128T, ASP201T, ASP201U, ASP71T, ASP73T, GLN187U, GLN202T, GLN202U, GLU183U, GLU207U, GLY127T, GLY192T, GLY192U, GLY194T, GLY194U, GLY196T, GLY196U, HIS195T, HIS195U, HIS199T, HIS199U, HIS206T, HIS206U, ILE178U, ILE181U, LEU130T, LEU137U, LEU188T, LEU188U, LEU204U, LEU205T, LEU77T, LEU80T, LYS141U, LYS179U, LYS193T, LYS193U, MET203T, MET203U, PHE200T, PHE200U, PHE67T, PHE70T, SER182U, TRP198T, TRP198U, TYR184U, TYR69T, VAL185U, VAL191U, VAL197T, VAL197U, VAL75T
• T-V: LEU111V, PHE18T
• U-W: ILE14U, MET116W