3A5D

inter-subunit interaction and quaternary rearrangement defined by the central stalk of prokaryotic v1-atpase

• Total interactions analyzed: 120
• Total true interactions: 32
• Strongest Interaction:
  • Chains: J-M
  • Int. Res.: 112
  • Norm. En. per Res.: -0.9732
• Hub Node: C(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	0.0	0.0	-14.1968	-14.1968	163	26	11	6249	0	81	74
A-F	-3.234	0.0	136.235	133.001	189	85	7	8001	0	110	93
A-G	0.0	0.0	-4.6556	-4.6556	40	0	4	786	0	25	11
B-D	-16.3048	0.0	168.793	152.4882	132	69	4	6263	0	72	55
B-E	-16.4773	0.0	-11.0252	-27.5025	111	30	10	4493	0	55	52
B-G	0.0	0.0	-11.6527	-11.6527	39	0	2	1054	0	31	18
B-H	0.0	0.0	10.3534	10.3534	27	21	9	1252	0	10	9
C-E	-28.5053	0.0	604.994	576.4887	195	170	11	9360	0	111	96
C-F	-3.9812	0.0	12.5518	8.5706	141	47	11	5892	0	67	64
C-G	0.0	0.0	-2.1601	-2.1601	28	0	0	344	0	22	17
C-K	0.0	0.0	-0.8189	-0.8189	10	0	0	123	0	12	13
D-G	0.0	0.0	-2.7245	-2.7245	36	0	1	558	0	33	38
E-G	0.0	0.0	-7.2751	-7.2751	33	0	1	654	0	26	34
E-H	0.0	0.0	-0.1625	-0.1625	7	0	0	62	0	6	5
F-G	0.0	0.0	-4.4274	-4.4274	26	0	1	548	0	13	23
F-K	0.0	0.0	-0.9634	-0.9634	15	16	0	798	0	11	15
G-H	0.0	0.0	-22.4892	-22.4892	78	4	13	2256	0	33	43
I-L	-5.2281	0.0	118.039	112.8109	170	70	14	7091	0	84	70
I-N	-3.1821	0.0	1055.83	1052.6479	199	162	9	9219	0	117	100
I-O	0.0	0.0	-7.7327	-7.7327	41	0	5	854	0	25	11
J-L	-13.7291	0.0	-51.9759	-65.705	125	38	4	5744	0	73	53
J-M	-25.8191	0.0	-83.1813	-109.0004	112	9	9	4524	0	54	54
J-O	0.0	0.0	-4.9093	-4.9093	36	0	1	661	0	27	17
J-P	0.0	0.0	34.3417	34.3417	23	27	7	1397	0	12	7
K-M	-14.3404	0.0	447.752	433.4116	186	101	9	8222	0	108	93
K-N	0.0	0.0	-35.4685	-35.4685	143	18	8	4808	0	69	65
K-O	0.0	0.0	-8.8965	-8.8965	30	0	2	783	0	23	19
K-P	0.0	0.0	-0.0121	-0.0121	3	0	0	12	0	10	8
L-O	0.0	0.0	-6.4815	-6.4815	43	0	1	877	0	37	39
M-O	0.0	0.0	-7.3946	-7.3946	33	0	1	680	0	23	32
N-O	0.0	0.0	-3.3464	-3.3464	25	0	0	428	0	12	22
O-P	0.0	0.0	-24.1829	-24.1829	86	3	14	2629	0	33	44

Interface residues

• A-D: ALA224D, ALA22A, ALA266D, ALA272D, ALA273D, ALA346A, ALA355A, ALA356A, ALA359A, ALA360A, ALA365A, ALA397D, ALA403D, ALA453A, ALA462A, ALA475A, ALA479A, ALA47A, ALA69D, ARG199D, ARG23A, ARG268D, ARG274D, ARG281D, ARG341D, ARG345D, ARG357A, ARG364A, ARG401A, ARG41A, ARG460A, ARG481A, ASN262D, ASN425A, ASP200A, ASP225D, ASP226D, ASP26A, ASP318D, ASP402D, ASP43A, ASP452A, ASP45A, ASP474A, ASP478A, ASP67D, GLN198D, GLN397A, GLN459A, GLN477A, GLU200D, GLU265D, GLU269D, GLU275D, GLU276D, GLU342A, GLU342D, GLU343A, GLU347A, GLU348A, GLU363A, GLU393A, GLU401D, GLU456A, GLU480A, GLY157D, GLY16D, GLY195D, GLY21A, GLY221A, GLY271D, GLY279D, GLY282D, GLY347D, GLY349A, GLY366A, GLY400D, GLY404A, GLY426A, GLY44A, GLY463A, GLY65D, HIS344D, ILE11D, ILE14D, ILE196D, ILE270D, ILE277D, ILE27A, ILE348D, ILE398D, ILE399D, ILE39A, ILE402A, ILE40A, ILE467A, LEU158D, LEU18D, LEU199A, LEU20A, LEU267D, LEU341A, LEU343D, LEU354A, LEU395D, LEU400A, LEU42A, LEU430A, LEU457A, LEU458A, LEU464A, LEU476A, LEU66D, LEU68D, LYS198A, LYS223D, LYS346D, LYS367A, LYS394D, MET24A, MET344A, MET391A, PHE361A, PRO159D, PRO17D, PRO201A, PRO227D, PRO278D, PRO317D, PRO345A, PRO351A, PRO352A, PRO70A, SER156D, SER15D, SER202D, SER338A, SER392A, SER398A, SER429A, SER455A, THR12D, THR197D, THR223A, THR228D, THR261D, THR46A, THR63D, THR64D, THR70D, THR71D, TRP424A, TYR13D, TYR203D, TYR25A, TYR283D, TYR350A, TYR353A, TYR362A, TYR428A, VAL396D, VAL403A, VAL471A
• A-F: ALA10A, ALA123F, ALA13A, ALA16A, ALA28F, ALA292F, ALA298F, ALA31F, ALA333A, ALA385F, ALA387F, ALA397F, ALA403F, ALA411A, ALA414A, ALA475A, ALA55F, ARG124F, ARG125F, ARG258A, ARG274F, ARG280F, ARG281F, ARG297F, ARG321F, ARG329A, ARG335A, ARG360F, ARG416A, ARG417A, ARG453F, ARG550A, ASN260A, ASN293A, ASN363F, ASN388F, ASN498A, ASP264A, ASP290F, ASP327F, ASP380F, ASP390A, ASP391F, ASP402F, ASP474A, ASP54A, GLN148F, GLN310F, GLN336F, GLN381F, GLN469A, GLU257A, GLU261A, GLU268A, GLU271A, GLU275F, GLU276F, GLU296F, GLU332A, GLU334F, GLU336A, GLU348A, GLU393A, GLU492A, GLU49F, GLU52F, GLU53F, GLU546A, GLY116F, GLY11A, GLY147F, GLY231A, GLY256A, GLY259A, GLY279F, GLY285F, GLY299F, GLY30F, GLY330F, GLY349A, GLY388A, GLY389A, GLY400F, GLY449F, GLY472A, GLY549A, GLY57A, HIS323F, HIS418A, ILE15A, ILE277F, ILE294F, ILE325F, ILE32F, ILE332F, ILE398F, ILE399F, ILE467A, ILE48F, ILE57F, ILE9A, LEU117F, LEU266A, LEU27F, LEU291F, LEU328F, LEU355F, LEU358F, LEU361F, LEU382F, LEU395F, LEU404F, LEU413A, LEU470A, LEU58A, LEU91A, LYS126F, LYS149F, LYS376F, LYS394F, LYS452F, LYS456F, LYS59A, LYS8A, MET262A, MET294A, MET391A, PHE230A, PHE269A, PHE415A, PRO127F, PRO12A, PRO229A, PRO270A, PRO278F, PRO295A, PRO324F, PRO326F, PRO345A, PRO354F, PRO356F, PRO386A, PRO387A, PRO473A, SER292A, SER339A, SER357F, SER379F, SER384F, SER385A, SER412A, SER455F, SER51F, SER56A, THR263A, THR289F, THR291A, THR293F, THR309F, THR322F, THR329F, THR333F, THR405F, THR55A, TYR286F, TYR288F, TYR295F, TYR29F, TYR331F, TYR350A, TYR383F, TYR386F, TYR500A, TYR54F, TYR553A, VAL122F, VAL14A, VAL265A, VAL267A, VAL296A, VAL300F, VAL301F, VAL308F, VAL468A, VAL471A, VAL47F, VAL50F, VAL56F, VAL60A
• A-G: ALA203G, ALA346A, ALA475A, ARG15G, ARG173G, ARG19G, ASP390A, GLN13G, GLN166G, GLN17G, GLN3G, GLN469A, GLU202G, GLU347A, GLU348A, GLU466A, GLY16G, GLY199G, GLY349A, GLY388A, GLY389A, GLY472A, ILE169G, ILE172G, ILE467A, LEU11G, LEU12G, LEU20G, LEU470A, LYS195G, LYS198G, LYS23G, MET1G, MET344A, MET391A, PRO345A, SER2G, SER392A, VAL471A, VAL4G
• B-D: ALA10B, ALA123D, ALA13B, ALA16B, ALA28D, ALA292D, ALA297B, ALA298D, ALA31D, ALA333B, ALA346B, ALA55D, ARG124D, ARG125D, ARG146D, ARG258B, ARG274D, ARG280D, ARG297D, ARG329B, ARG335B, ARG340B, ARG360D, ASN23D, ASN260B, ASN293B, ASN364D, ASP264B, ASP26D, ASP290D, ASP327D, ASP54B, GLN148D, GLN7B, GLU128D, GLU257B, GLU261B, GLU268B, GLU275D, GLU276D, GLU296D, GLU332B, GLU334D, GLU336B, GLU342B, GLU343B, GLU347B, GLU348B, GLU49D, GLU52D, GLU53D, GLU62B, GLY11B, GLY147D, GLY231B, GLY256B, GLY259B, GLY279D, GLY285D, GLY299D, GLY30D, GLY330D, GLY349B, GLY57B, GLY61B, ILE15B, ILE277D, ILE294D, ILE32D, ILE332D, ILE337B, ILE48D, ILE57D, ILE9B, LEU117D, LEU266B, LEU27D, LEU291D, LEU328D, LEU341B, LEU361D, LEU58B, LEU91B, LYS126D, LYS149D, LYS59B, LYS8B, MET262B, MET287D, MET294B, MET344B, PHE230B, PRO127D, PRO12B, PRO278D, PRO284D, PRO295B, PRO345B, PRO387B, SER292B, SER338B, SER339B, SER51D, SER56B, THR115D, THR263B, THR289D, THR291B, THR293D, THR322D, THR333D, THR46B, THR55B, TYR283D, TYR286D, TYR288D, TYR295D, TYR29D, TYR331D, TYR350B, TYR54D, VAL122D, VAL14B, VAL265B, VAL267B, VAL296B, VAL300D, VAL47D, VAL50D, VAL56D, VAL60B, VAL79D
• B-E: ALA192B, ALA224E, ALA22B, ALA266E, ALA272E, ALA273E, ALA346B, ALA355B, ALA356B, ALA359B, ALA360B, ALA365B, ALA47B, ALA69E, ARG190B, ARG191B, ARG197B, ARG199E, ARG23B, ARG268E, ARG281E, ARG357B, ARG364B, ARG401B, ARG41B, ASN262E, ASP200B, ASP225E, ASP226E, ASP26B, ASP318E, ASP43B, ASP45B, ASP67E, GLN198E, GLN206E, GLN397B, GLU200E, GLU265E, GLU269E, GLU276E, GLU343B, GLU347B, GLU363B, GLY157E, GLY16E, GLY195E, GLY21B, GLY221B, GLY222B, GLY271E, GLY282E, GLY366B, GLY44B, GLY65E, GLY68B, ILE11E, ILE14E, ILE196E, ILE270E, ILE277E, ILE27B, ILE2B, ILE39B, ILE402B, ILE40B, LEU199B, LEU19E, LEU201E, LEU20B, LEU354B, LEU400B, LEU42B, LEU430B, LEU66E, LEU68E, LEU69B, LYS198B, LYS223E, LYS367B, MET19B, MET24B, MET344B, PHE20E, PHE361B, PRO201B, PRO278E, PRO317E, PRO345B, PRO351B, PRO352B, PRO70B, SER156E, SER15E, SER202E, SER392B, THR12E, THR197E, THR223B, THR228E, THR46B, THR63E, THR64E, THR70E, THR71E, TYR13E, TYR203E, TYR25B, TYR283E, TYR353B, TYR362B
• B-G: ALA163G, ALA203G, ALA21G, ALA346B, ALA475B, ARG188G, ARG193G, ARG196G, ARG204G, ARG32G, ASP474B, GLN469B, GLU189G, GLU342B, GLU347B, GLU348B, GLY199G, GLY24G, GLY349B, GLY472B, ILE197G, LEU27G, LEU28G, LEU35G, LEU470B, LYS195G, LYS200G, LYS29G, LYS31G, MET344B, PHE192G, PRO170G, PRO345B, PRO473B, SER392B, VAL167G, VAL25G, VAL468B, VAL471B
• B-H: ALA475B, ALA479B, ARG481B, ARG91H, ARG95H, ASP101H, ASP474B, ASP478B, GLN477B, GLU480B, GLY472B, GLY99H, ILE102H, ILE467B, ILE98H, LEU104H, LEU470B, LEU476B, LEU93H, LYS103H, MET90H, PHE100H, PRO473B, THR97H, VAL468B, VAL471B, VAL94H
• C-E: ALA10C, ALA123E, ALA13C, ALA16C, ALA28E, ALA292E, ALA298E, ALA31E, ALA333C, ALA385E, ALA387E, ALA403E, ALA411C, ALA414C, ALA55E, ARG124E, ARG125E, ARG258C, ARG274E, ARG280E, ARG281E, ARG297E, ARG321E, ARG329C, ARG335C, ARG360E, ARG416C, ARG417C, ARG453E, ARG550C, ASN260C, ASN290C, ASN293C, ASN363E, ASN364E, ASN388E, ASP264C, ASP290E, ASP327E, ASP353E, ASP380E, ASP390C, ASP391E, ASP474C, ASP54C, CYS255C, GLN148E, GLN310E, GLN336E, GLN381E, GLN469C, GLU257C, GLU261C, GLU268C, GLU271C, GLU275E, GLU276E, GLU296E, GLU302E, GLU332C, GLU334E, GLU336C, GLU348C, GLU393C, GLU492C, GLU49E, GLU52E, GLU53E, GLU546C, GLY116E, GLY11C, GLY147E, GLY231C, GLY256C, GLY259C, GLY279E, GLY285E, GLY299E, GLY30E, GLY330E, GLY349C, GLY388C, GLY389C, GLY449E, GLY472C, GLY549C, GLY57C, HIS323E, HIS418C, ILE15C, ILE277E, ILE294E, ILE325E, ILE32E, ILE332E, ILE398E, ILE399E, ILE48E, ILE57E, ILE83C, ILE9C, LEU117E, LEU266C, LEU272C, LEU27E, LEU291E, LEU328E, LEU355E, LEU358E, LEU361E, LEU382E, LEU395E, LEU404E, LEU413C, LEU470C, LEU58C, LEU91C, LYS126E, LYS149E, LYS304E, LYS376E, LYS394E, LYS452E, LYS59C, LYS8C, MET262C, MET287E, MET294C, MET391C, PHE230C, PHE269C, PHE415C, PRO121E, PRO127E, PRO12C, PRO229C, PRO270C, PRO278E, PRO295C, PRO324E, PRO326E, PRO345C, PRO354E, PRO356E, PRO386C, PRO387C, PRO473C, SER292C, SER328C, SER339C, SER357E, SER379E, SER384E, SER385C, SER412C, SER455E, SER51E, SER56C, THR115E, THR263C, THR289E, THR291C, THR293E, THR309E, THR322E, THR329E, THR333E, THR55C, TYR283E, TYR286E, TYR288E, TYR295E, TYR29E, TYR331E, TYR383E, TYR386E, TYR500C, TYR54E, TYR553C, VAL122E, VAL14C, VAL236C, VAL265C, VAL267C, VAL296C, VAL300E, VAL301E, VAL308E, VAL390E, VAL468C, VAL471C, VAL47E, VAL50E, VAL56E, VAL60C
• C-F: ALA224F, ALA22C, ALA266F, ALA272F, ALA273F, ALA346C, ALA355C, ALA356C, ALA359C, ALA360C, ALA365C, ALA397F, ALA69F, ARG197C, ARG199F, ARG231F, ARG23C, ARG268F, ARG274F, ARG280F, ARG281F, ARG345F, ARG357C, ARG364C, ARG401C, ARG41C, ASN262F, ASN425C, ASP200C, ASP225F, ASP226F, ASP26C, ASP318F, ASP43C, ASP45C, ASP67F, CYS264F, GLN198F, GLN206F, GLN397C, GLN459C, GLU200F, GLU265F, GLU269F, GLU275F, GLU276F, GLU342C, GLU343C, GLU347C, GLU348C, GLU363C, GLU393C, GLU401F, GLU466C, GLY157F, GLY16F, GLY195F, GLY21C, GLY221C, GLY222C, GLY271F, GLY279F, GLY282F, GLY347F, GLY349C, GLY366C, GLY400F, GLY404C, GLY426C, GLY44C, GLY65F, ILE11F, ILE14F, ILE196F, ILE270F, ILE277F, ILE27C, ILE398F, ILE399F, ILE39C, ILE402C, ILE40C, ILE467C, LEU199C, LEU19F, LEU20C, LEU267F, LEU341C, LEU354C, LEU358C, LEU400C, LEU42C, LEU430C, LEU470C, LEU66F, LEU68F, LYS198C, LYS223F, LYS346F, LYS367C, MET24C, MET344C, MET391C, PHE20F, PHE361C, PHE48C, PRO17F, PRO201C, PRO227F, PRO278F, PRO284F, PRO317F, PRO345C, PRO351C, PRO352C, PRO70C, SER156F, SER15F, SER202F, SER315F, SER392C, THR12F, THR197F, THR223C, THR228F, THR46C, THR63F, THR64F, THR70F, THR71F, TYR13F, TYR203F, TYR25C, TYR283F, TYR350C, TYR353C, TYR362C, TYR428C, VAL396F, VAL403C, VAL471C
• C-G: ALA346C, ARG186G, ARG193G, ARG204G, ASP190G, ASP390C, GLN175G, GLN469C, GLU202G, GLU205G, GLU347C, GLU348C, GLY171G, GLY349C, GLY472C, ILE169G, ILE172G, ILE176G, ILE197G, ILE201G, LEU194G, LEU470C, LYS198G, LYS200G, MET344C, PRO345C, VAL168G, VAL471C
• C-K: ARG440C, GLU374K, GLU375K, GLU441C, GLU445C, GLU449C, GLY372K, GLY373K, MET122K, PRO437C
• D-G: ALA203G, ALA397D, ARG196G, ARG19G, ARG204G, ARG280D, ARG281D, ARG321D, ASP26G, ASP318D, ASP319D, ASP320D, ASP391D, GLN22G, GLN3G, GLU202G, GLU276D, GLY199G, GLY279D, GLY282D, ILE277D, ILE392D, ILE398D, ILE399D, LEU18G, LEU395D, LYS195G, LYS200G, LYS23G, LYS394D, PHE192G, PRO278D, PRO6G, THR322D, THR7G, VAL4G
• E-G: ALA174G, ALA397E, ARG193G, ARG196G, ARG204G, ARG280E, ARG281E, ASP190G, ASP320E, GLN175G, GLN185G, GLU189G, GLU275E, GLU276E, GLY171G, GLY279E, GLY282E, ILE169G, ILE172G, ILE197G, ILE201G, ILE277E, ILE398E, ILE399E, LEU164G, LEU194G, LYS200G, LYS394E, PHE192G, PRO278E, TYR283E, VAL167G, VAL168G
• E-H: ARG95H, ASP402E, GLU401E, GLY400E, GLY99H, LYS96H, PHE100H
• F-G: ALA203G, ARG280F, ARG281F, ARG321F, ASP319F, ASP320F, GLU202G, GLU205G, GLU275F, GLU276F, GLY279F, GLY282F, ILE169G, ILE172G, ILE197G, ILE201G, ILE277F, ILE398F, LEU194G, LYS195G, LYS198G, MET1G, PRO278F, SER2G, THR322F, TYR283F
• F-K: ARG156K, ASN429F, ASP127K, ASP177K, GLN425F, GLN427F, GLN428F, GLU128K, GLU159K, GLY126K, GLY426F, LYS124K, LYS158K, PRO125K, VAL157K
• G-H: ALA134G, ALA136G, ALA141G, ALA163G, ALA16H, ALA46G, ALA46H, ALA49G, ALA52G, ALA75H, ALA80H, ARG132G, ARG139G, ARG14H, ARG159G, ARG160G, ARG50G, ASN142G, ASP85H, GLN11H, GLN55G, GLN82H, GLU135G, GLU144G, GLU152G, GLU153G, GLU38G, GLU45G, GLU87H, GLU8H, GLY12H, GLY17H, GLY76H, GLY83H, HIS84H, ILE138G, ILE154G, ILE74H, ILE98H, LEU137G, LEU15H, LEU164G, LEU18H, LEU27G, LEU28G, LEU35G, LEU42G, LEU44H, LEU53G, LEU71H, LEU72H, LEU77H, LEU93H, LYS148G, LYS149G, LYS156G, LYS31G, LYS78H, LYS96H, MET1H, MET47G, MET90H, PHE13H, PHE39G, PHE81H, PRO73H, THR145G, THR97H, THR9H, TYR133G, TYR89H, VAL140G, VAL167G, VAL3H, VAL43G, VAL70H, VAL86H, VAL94H
• I-L: ALA224L, ALA22I, ALA266L, ALA272L, ALA273L, ALA346I, ALA355I, ALA356I, ALA359I, ALA360I, ALA365I, ALA397L, ALA462I, ALA475I, ALA479I, ALA47I, ALA69L, ARG197I, ARG199L, ARG23I, ARG268L, ARG274L, ARG281L, ARG341L, ARG345L, ARG357I, ARG364I, ARG401I, ARG41I, ARG460I, ASN262L, ASN425I, ASP200I, ASP225L, ASP226L, ASP26I, ASP318L, ASP402L, ASP43I, ASP452I, ASP45I, ASP474I, ASP478I, ASP67L, GLN198L, GLN206L, GLN397I, GLN459I, GLN477I, GLU200L, GLU265L, GLU269L, GLU275L, GLU276L, GLU342I, GLU342L, GLU343I, GLU347I, GLU348I, GLU363I, GLU393I, GLU401L, GLU456I, GLU480I, GLY157L, GLY16L, GLY195L, GLY21I, GLY221I, GLY222I, GLY271L, GLY279L, GLY282L, GLY347L, GLY349I, GLY366I, GLY400L, GLY404I, GLY426I, GLY44I, GLY463I, GLY472I, GLY65L, HIS344L, ILE11L, ILE14L, ILE196L, ILE229L, ILE270L, ILE277L, ILE27I, ILE348L, ILE398L, ILE399L, ILE39I, ILE402I, ILE40I, ILE467I, LEU158L, LEU18L, LEU199I, LEU19L, LEU20I, LEU267L, LEU341I, LEU343L, LEU354I, LEU358I, LEU395L, LEU400I, LEU42I, LEU430I, LEU457I, LEU458I, LEU464I, LEU476I, LEU66L, LEU68L, LYS198I, LYS223L, LYS346L, LYS367I, LYS394L, MET19I, MET24I, MET344I, MET391I, PHE20L, PHE361I, PHE48I, PRO17L, PRO201I, PRO227L, PRO278L, PRO317L, PRO345I, PRO351I, PRO352I, PRO473I, PRO70I, SER156L, SER15L, SER202L, SER338I, SER392I, SER398I, SER427I, SER429I, SER455I, THR12L, THR197L, THR223I, THR228L, THR46I, THR63L, THR64L, THR70L, THR71L, TRP424I, TYR13L, TYR203L, TYR25I, TYR283L, TYR350I, TYR353I, TYR362I, TYR428I, VAL396L, VAL403I, VAL471I
• I-N: ALA10I, ALA123N, ALA13I, ALA16I, ALA28N, ALA292N, ALA298N, ALA31N, ALA333I, ALA346I, ALA385N, ALA387N, ALA403N, ALA411I, ALA414I, ALA55N, ARG124N, ARG125N, ARG258I, ARG274N, ARG280N, ARG281N, ARG297N, ARG321N, ARG329I, ARG335I, ARG340I, ARG360N, ARG416I, ARG417I, ARG453N, ARG550I, ASN260I, ASN290I, ASN293I, ASN363N, ASN388N, ASN498I, ASP264I, ASP26N, ASP290N, ASP327N, ASP380N, ASP390I, ASP391N, ASP474I, ASP493I, ASP54I, GLN148N, GLN310N, GLN377N, GLN381N, GLN469I, GLU257I, GLU261I, GLU268I, GLU271I, GLU275N, GLU276N, GLU296N, GLU302N, GLU332I, GLU334N, GLU336I, GLU342I, GLU343I, GLU347I, GLU348I, GLU393I, GLU492I, GLU49N, GLU52N, GLU53N, GLU546I, GLY116N, GLY11I, GLY147N, GLY231I, GLY256I, GLY259I, GLY279N, GLY285N, GLY299N, GLY30N, GLY330N, GLY349I, GLY388I, GLY389I, GLY449N, GLY472I, GLY549I, GLY57I, HIS323N, HIS418I, HIS501I, ILE15I, ILE277N, ILE294N, ILE325N, ILE32N, ILE332N, ILE398N, ILE399N, ILE48N, ILE57N, ILE9I, LEU117N, LEU266I, LEU27N, LEU291N, LEU328N, LEU355N, LEU358N, LEU361N, LEU382N, LEU395N, LEU404N, LEU413I, LEU470I, LEU58I, LYS126N, LYS149N, LYS376N, LYS394N, LYS452N, LYS456N, LYS59I, LYS8I, MET262I, MET287N, MET294I, MET344I, MET391I, PHE230I, PHE269I, PHE415I, PRO121N, PRO127N, PRO12I, PRO229I, PRO270I, PRO278N, PRO295I, PRO324N, PRO326N, PRO345I, PRO354N, PRO356N, PRO386I, PRO387I, PRO473I, SER292I, SER328I, SER339I, SER357N, SER379N, SER384N, SER385I, SER412I, SER455N, SER51N, SER56I, THR115N, THR263I, THR289N, THR291I, THR293N, THR309N, THR322N, THR329N, THR333N, THR405N, THR55I, TYR286N, TYR288N, TYR295N, TYR29N, TYR331N, TYR350I, TYR383N, TYR386N, TYR500I, TYR54N, TYR553I, VAL122N, VAL14I, VAL265I, VAL267I, VAL296I, VAL300N, VAL301N, VAL308N, VAL390N, VAL468I, VAL471I, VAL47N, VAL50N, VAL56N, VAL60I
• I-O: ALA203O, ALA346I, ALA475I, ARG15O, ARG173O, ARG19O, ARG8O, ASP390I, GLN13O, GLN166O, GLN17O, GLN3O, GLN469I, GLU202O, GLU347I, GLU348I, GLU466I, GLY16O, GLY199O, GLY349I, GLY389I, GLY472I, ILE169O, ILE172O, ILE467I, LEU11O, LEU12O, LEU20O, LEU470I, LYS195O, LYS198O, LYS23O, MET344I, MET391I, PRO170O, PRO345I, SER2O, SER392I, VAL468I, VAL471I, VAL4O
• J-L: ALA10J, ALA123L, ALA13J, ALA16J, ALA28L, ALA292L, ALA297J, ALA298L, ALA31L, ALA333J, ALA346J, ALA55L, ARG124L, ARG125L, ARG146L, ARG258J, ARG274L, ARG280L, ARG297L, ARG335J, ARG340J, ARG360L, ASN260J, ASN293J, ASN364L, ASP264J, ASP290L, ASP327L, ASP54J, GLN148L, GLN7J, GLU128L, GLU257J, GLU261J, GLU268J, GLU275L, GLU276L, GLU296L, GLU332J, GLU334L, GLU336J, GLU342J, GLU343J, GLU348J, GLU49L, GLU52L, GLU53L, GLY116L, GLY11J, GLY147L, GLY256J, GLY259J, GLY279L, GLY285L, GLY299L, GLY30L, GLY330L, GLY349J, GLY57J, GLY61J, ILE15J, ILE277L, ILE294L, ILE32L, ILE332L, ILE337J, ILE48L, ILE57L, ILE9J, LEU117L, LEU266J, LEU27L, LEU291L, LEU341J, LEU361L, LEU58J, LEU91J, LYS126L, LYS149L, LYS59J, LYS8J, MET262J, MET287L, MET294J, MET344J, PRO127L, PRO12J, PRO278L, PRO284L, PRO295J, PRO345J, PRO387J, SER292J, SER338J, SER339J, SER51L, SER56J, THR115L, THR263J, THR289L, THR291J, THR293L, THR322L, THR329L, THR333L, THR55J, TYR283L, TYR286L, TYR288L, TYR295L, TYR29L, TYR331L, TYR350J, TYR54L, VAL122L, VAL14J, VAL265J, VAL267J, VAL296J, VAL300L, VAL47L, VAL50L, VAL56L, VAL60J, VAL79L
• J-M: ALA192J, ALA224M, ALA22J, ALA266M, ALA272M, ALA273M, ALA346J, ALA355J, ALA356J, ALA359J, ALA360J, ALA365J, ALA69M, ARG190J, ARG197J, ARG199M, ARG23J, ARG268M, ARG281M, ARG357J, ARG364J, ARG401J, ARG41J, ASN262M, ASP200J, ASP225M, ASP226M, ASP26J, ASP318M, ASP43J, ASP45J, ASP67M, GLN198M, GLN206M, GLN397J, GLU200M, GLU265M, GLU269M, GLU275M, GLU276M, GLU343J, GLU347J, GLU363J, GLY157M, GLY16M, GLY195M, GLY21J, GLY221J, GLY222J, GLY271M, GLY282M, GLY366J, GLY44J, GLY65M, GLY68J, ILE11M, ILE14M, ILE196M, ILE270M, ILE277M, ILE27J, ILE2J, ILE39J, ILE402J, ILE40J, LEU199J, LEU19M, LEU201M, LEU20J, LEU354J, LEU358J, LEU400J, LEU42J, LEU430J, LEU66M, LEU68M, LEU69J, LYS198J, LYS223M, LYS367J, MET19J, MET24J, MET344J, PHE20M, PHE361J, PRO201J, PRO278M, PRO317M, PRO345J, PRO351J, PRO352J, PRO70J, SER156M, SER15M, SER202M, SER392J, THR12M, THR197M, THR223J, THR228M, THR46J, THR63M, THR64M, THR70M, THR71M, TYR13M, TYR203M, TYR25J, TYR283M, TYR350J, TYR353J, TYR362J
• J-O: ALA163O, ALA203O, ALA21O, ALA346J, ARG188O, ARG193O, ARG196O, ARG204O, ARG32O, ASP474J, GLN469J, GLU189O, GLU342J, GLU347J, GLU348J, GLY199O, GLY24O, GLY349J, GLY472J, ILE197O, LEU27O, LEU28O, LEU35O, LEU470J, LYS195O, LYS200O, LYS31O, MET344J, PHE192O, PRO345J, PRO473J, SER392J, VAL167O, VAL25O, VAL468J, VAL471J
• J-P: ALA475J, ALA479J, ARG95P, ASP101P, ASP474J, ASP478J, GLN477J, GLY472J, GLY99P, ILE102P, ILE467J, ILE98P, LEU104P, LEU470J, LEU476J, LYS103P, LYS96P, PHE100P, PRO473J, THR97P, VAL468J, VAL471J, VAL94P
• K-M: ALA10K, ALA123M, ALA13K, ALA16K, ALA292M, ALA298M, ALA31M, ALA333K, ALA346K, ALA385M, ALA387M, ALA403M, ALA411K, ALA414K, ALA475K, ALA55M, ARG124M, ARG125M, ARG258K, ARG280M, ARG281M, ARG297M, ARG321M, ARG329K, ARG335K, ARG360M, ARG416K, ARG417K, ARG453M, ARG550K, ASN260K, ASN290K, ASN293K, ASN363M, ASN388M, ASP264K, ASP290M, ASP327M, ASP380M, ASP390K, ASP391M, ASP474K, ASP54K, GLN148M, GLN310M, GLN381M, GLN469K, GLU257K, GLU261K, GLU268K, GLU271K, GLU275M, GLU276M, GLU296M, GLU332K, GLU334M, GLU336K, GLU343K, GLU347K, GLU348K, GLU393K, GLU492K, GLU49M, GLU52M, GLU53M, GLU546K, GLY116M, GLY11K, GLY147M, GLY231K, GLY256K, GLY259K, GLY279M, GLY285M, GLY299M, GLY30M, GLY330M, GLY349K, GLY388K, GLY389K, GLY400M, GLY449M, GLY472K, GLY549K, GLY57K, HIS323M, HIS418K, ILE15K, ILE277M, ILE294M, ILE325M, ILE32M, ILE332M, ILE398M, ILE399M, ILE467K, ILE48M, ILE57M, ILE9K, LEU117M, LEU266K, LEU27M, LEU291M, LEU328M, LEU355M, LEU358M, LEU361M, LEU395M, LEU404M, LEU470K, LEU58K, LYS126M, LYS149M, LYS376M, LYS394M, LYS452M, LYS59K, LYS8K, MET262K, MET287M, MET294K, MET344K, MET391K, PHE230K, PHE269K, PHE415K, PRO127M, PRO12K, PRO229K, PRO270K, PRO278M, PRO324M, PRO326M, PRO345K, PRO354M, PRO356M, PRO386K, PRO387K, PRO473K, SER292K, SER328K, SER339K, SER357M, SER379M, SER384M, SER385K, SER392K, SER412K, SER51M, SER56K, THR115M, THR263K, THR289M, THR291K, THR293M, THR322M, THR329M, THR333M, THR405M, THR55K, TYR283M, TYR286M, TYR288M, TYR295M, TYR29M, TYR331M, TYR350K, TYR383M, TYR386M, TYR500K, TYR54M, VAL122M, VAL14K, VAL265K, VAL267K, VAL296K, VAL300M, VAL301M, VAL308M, VAL468K, VAL471K, VAL47M, VAL50M, VAL56M, VAL60K, VAL79M
• K-N: ALA192K, ALA224N, ALA22K, ALA266N, ALA272N, ALA273N, ALA346K, ALA355K, ALA356K, ALA359K, ALA360K, ALA365K, ALA397N, ALA69N, ARG190K, ARG191K, ARG197K, ARG199N, ARG23K, ARG268N, ARG274N, ARG281N, ARG345N, ARG357K, ARG364K, ARG401K, ARG41K, ASN262N, ASN425K, ASP200K, ASP225N, ASP226N, ASP26K, ASP318N, ASP319N, ASP43K, ASP45K, ASP67N, GLN196K, GLN198N, GLN206N, GLN397K, GLN459K, GLU200N, GLU265N, GLU269N, GLU275N, GLU276N, GLU343K, GLU347K, GLU363K, GLU401N, GLU456K, GLU466K, GLY155N, GLY157N, GLY16N, GLY195N, GLY21K, GLY221K, GLY222K, GLY271N, GLY282N, GLY347N, GLY366K, GLY400N, GLY404K, GLY426K, GLY44K, GLY65N, ILE11N, ILE14N, ILE196N, ILE205N, ILE270N, ILE277N, ILE27K, ILE398N, ILE399N, ILE39K, ILE402K, ILE40K, ILE467K, LEU158N, LEU199K, LEU201N, LEU20K, LEU267N, LEU341K, LEU354K, LEU358K, LEU400K, LEU42K, LEU430K, LEU470K, LEU66N, LEU68N, LYS198K, LYS223N, LYS346N, LYS367K, MET24K, MET316N, MET344K, MET391K, PHE361K, PRO159N, PRO17N, PRO201K, PRO278N, PRO317N, PRO345K, PRO351K, PRO352K, SER156N, SER15N, SER202N, SER315N, SER392K, SER398K, SER427K, SER429K, SER455K, THR12N, THR197N, THR228N, THR399K, THR46K, THR63N, THR64N, THR70N, THR71N, TRP424K, TYR13N, TYR203N, TYR25K, TYR283N, TYR353K, TYR362K, TYR428K, VAL195K, VAL403K, VAL471K
• K-O: ALA346K, ARG186O, ARG193O, ARG204O, ASP190O, ASP390K, GLN175O, GLN469K, GLU202O, GLU205O, GLU342K, GLU347K, GLU348K, GLY171O, GLY349K, GLY472K, ILE169O, ILE172O, ILE176O, ILE197O, ILE201O, LEU194O, LEU470K, LYS198O, LYS200O, MET344K, PRO345K, TYR350K, VAL168O, VAL471K
• K-P: ARG64P, ASP478K, GLY533K
• L-O: ALA203O, ALA397L, ALA403L, ARG15O, ARG196O, ARG19O, ARG204O, ARG280L, ARG281L, ARG321L, ARG393L, ASP26O, ASP318L, ASP319L, ASP320L, ASP391L, GLN166O, GLN22O, GLN3O, GLU202O, GLU276L, GLY199O, GLY279L, GLY282L, ILE277L, ILE392L, ILE398L, ILE399L, LEU18O, LEU20O, LEU395L, LYS195O, LYS200O, LYS23O, LYS29O, LYS394L, PHE192O, PRO278L, PRO6O, THR322L, THR405L, THR7O, VAL4O
• M-O: ALA174O, ALA397M, ARG193O, ARG196O, ARG204O, ARG280M, ARG281M, ASP190O, ASP320M, GLN175O, GLN185O, GLU189O, GLU275M, GLU276M, GLY171O, GLY279M, GLY282M, ILE169O, ILE172O, ILE197O, ILE201O, ILE277M, ILE398M, ILE399M, LEU164O, LEU194O, LYS200O, LYS394M, PHE192O, PRO278M, TYR283M, VAL167O, VAL168O
• N-O: ALA203O, ARG280N, ARG281N, ASP320N, GLU202O, GLU205O, GLU275N, GLU276N, GLY199O, GLY279N, GLY282N, ILE169O, ILE172O, ILE197O, ILE201O, ILE277N, ILE398N, LEU194O, LYS195O, LYS198O, MET1O, PRO278N, SER2O, THR322N, TYR283N
• O-P: ALA10P, ALA134O, ALA136O, ALA141O, ALA163O, ALA16P, ALA34O, ALA46O, ALA46P, ALA49O, ALA52O, ALA75P, ALA80P, ARG132O, ARG139O, ARG14P, ARG159O, ARG160O, ARG32O, ARG50O, ARG91P, ASP54O, ASP85P, GLN55O, GLN82P, GLU135O, GLU144O, GLU152O, GLU153O, GLU38O, GLU45O, GLU48O, GLU79P, GLU87P, GLU8P, GLY12P, GLY17P, GLY41O, GLY76P, GLY83P, GLY88P, HIS84P, ILE138O, ILE154O, ILE74P, ILE98P, LEU137O, LEU15P, LEU164O, LEU18P, LEU27O, LEU28O, LEU35O, LEU42O, LEU44P, LEU53O, LEU71P, LEU72P, LEU77P, LEU93P, LYS148O, LYS149O, LYS156O, LYS31O, LYS51O, LYS78P, LYS96P, MET1P, MET47O, MET90P, PHE13P, PHE39O, PHE40O, PHE81P, PRO73P, THR145O, THR157O, THR97P, THR9P, TYR133O, TYR89P, VAL3P, VAL43O, VAL70P, VAL86P, VAL94P