2ZZD

recombinant thiocyanate hydrolase, air-oxidized form of holo-enzyme

• Total interactions analyzed: 66
• Total true interactions: 46
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 198
  • Norm. En. per Res.: -6.8905
• Hub Node: B(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-27.9236	7.8308	-229.41	-249.5028	82	5	1	8401	5	40	42
A-C	-174.7045	-182.8065	-495.931	-853.442	138	26	7	17917	14	44	25
A-E	-2.1013	19.1059	-93.8509	-76.8463	39	1	1	3661	0	16	16
A-F	0.0	5.2237	-23.4239	-18.2002	22	2	0	1061	0	7	6
A-J	0.0	-3.1838	-24.1823	-27.3661	18	3	0	1272	0	5	3
A-K	-16.2179	0.414	-159.2	-175.0038	59	3	7	6344	0	18	18
A-L	0.0	0.0	-2.729	-2.729	8	0	0	218	0	0	2
B-C	-194.9764	-154.5492	-975.366	-1324.8916	199	31	27	36219	19	100	77
B-D	0.0	19.3715	-95.8721	-76.5006	40	1	1	3758	0	16	16
B-E	-12.623	-45.5093	-300.752	-358.8842	111	11	7	11888	6	22	34
B-F	-9.3879	0.0	-18.9909	-28.3788	25	1	0	986	0	4	6
B-H	-74.4155	7.6331	-150.587	-217.3693	56	8	0	5292	0	8	3
B-J	-16.3161	0.6357	-158.964	-174.6444	60	7	7	6408	0	19	21
B-K	-61.4584	-63.2525	-348.065	-472.7759	149	8	8	14406	8	34	44
B-L	0.0	-1.8503	-58.918	-60.7683	38	3	1	2425	1	8	6
C-D	0.0	2.5053	-25.9492	-23.4439	22	0	0	1080	0	7	6
C-E	-9.7556	0.0	-18.3709	-28.1265	25	1	0	990	0	4	6
C-F	-5.1308	0.0	-69.2641	-74.3949	38	2	1	2573	0	8	4
C-J	0.0	0.0	-2.428	-2.428	8	0	0	204	0	0	2
C-K	0.0	-7.041	-61.0167	-68.0577	38	0	1	2415	2	9	6
D-E	-31.7368	7.9881	-234.324	-258.0726	85	7	1	8721	5	42	42
D-F	-174.3939	-182.9435	-509.025	-866.3624	141	30	7	18040	14	43	27
D-G	0.0	-12.0044	-41.1089	-53.1133	24	3	0	2049	1	10	8
D-H	-17.9112	0.7804	-156.75	-173.8809	59	7	7	6481	0	20	20
D-I	0.0	0.0	-2.4074	-2.4074	8	0	0	203	0	0	2
E-F	-203.365	-146.0231	-963.886	-1313.2741	201	47	27	36153	20	107	79
E-G	-13.651	0.5678	-158.395	-171.4782	60	6	7	6358	0	19	18
E-H	-58.6973	-62.298	-349.931	-470.9263	148	8	8	14384	8	34	44
E-I	0.0	-4.7416	-61.0987	-65.8403	38	0	1	2419	2	9	7
E-K	-68.5853	6.1297	-152.852	-215.3076	56	12	0	5294	0	6	3
F-G	0.0	0.0	-2.7033	-2.7033	8	0	0	217	0	0	2
F-H	0.0	-4.8523	-60.3072	-65.1595	38	0	1	2378	2	8	6
G-H	-39.6674	8.924	-231.092	-261.8354	83	4	1	8412	5	42	42
G-I	-196.8414	-181.7674	-499.076	-877.6849	142	31	7	17907	14	44	25
G-K	0.0	19.6391	-93.2094	-73.5704	39	1	1	3682	0	16	16
G-L	0.0	5.2797	-26.024	-20.7443	21	0	0	1076	0	7	5
H-I	-235.8874	-148.1623	-980.279	-1364.3287	198	36	27	36161	19	100	78
H-J	-8.4871	18.8789	-101.142	-90.7503	40	1	1	4000	0	16	16
H-K	-27.2549	-48.6978	-300.225	-376.1776	111	11	7	11939	6	22	33
H-L	-9.9949	0.0	-18.5374	-28.5323	25	1	0	988	0	4	6
I-J	-2.1813	5.3646	-26.7792	-23.5959	23	0	0	1090	0	7	6
I-K	-9.7557	0.0	-18.6594	-28.4151	26	1	0	983	0	4	6
I-L	-5.2471	0.0	-68.5231	-73.7702	39	2	1	2558	0	8	4
J-K	-33.4141	8.5692	-239.513	-264.3579	86	6	1	8848	5	43	42
J-L	-184.218	-183.7961	-513.762	-881.7762	142	28	7	18146	14	43	26
K-L	-216.6888	-147.5396	-971.93	-1336.1584	198	29	26	36015	20	98	75

Interface residues

• A-B: ALA16A, ALA76A, ALA77A, ALA80B, ALA81A, ALA87B, ARG12A, ARG41B, ARG45B, ARG55A, ARG61A, ARG82B, ARG90B, ARG91B, ARG92B, ASN84A, ASN95B, ASP11A, ASP122B, ASP24A, ASP47A, ASP49B, ASP50A, ASP79A, ASP97B, CYS96B, GLN124B, GLN94B, GLU104A, GLU53B, GLU78A, GLU80A, GLU85A, GLU88B, GLU89B, GLY51B, GLY52B, GLY83A, GLY83B, HIS14A, HIS15A, HIS37B, HIS48B, ILE119B, LEU101A, LEU114A, LEU48A, LEU51A, LEU79B, LYS123B, LYS93B, MET57A, PHE125B, PHE28A, PHE40B, PHE52A, PHE82A, PHE91A, PRO47B, PRO49A, PRO75A, PRO8A, SER74A, THR13A, THR20A, THR44B, THR54A, THR56A, THR58A, THR60A, THR86B, TRP102A, TRP10A, TRP81B, TRP85B, TYR43B, TYR53A, TYR59A, VAL46B, VAL50B, VAL84B, VAL9A
• A-C: ALA110A, ALA16A, ALA179C, ALA19A, ALA38C, ALA76A, ALA77A, ALA97A, ARG114C, ARG121A, ARG12A, ARG152C, ARG153C, ARG154C, ARG157C, ARG160C, ARG177C, ARG186C, ARG55A, ARG69A, ASN111A, ASN112C, ASN182C, ASP107A, ASP109C, ASP112A, ASP180C, ASP24A, ASP84C, CYS111C, CYS128C, CYS27A, CYS81C, GLN103C, GLN161C, GLN169C, GLN175C, GLN183C, GLN26A, GLN98A, GLU104A, GLU115A, GLU117A, GLU173C, GLU73A, GLU78A, GLU80A, GLU83C, GLU85A, GLY105C, GLY21A, GLY23A, GLY42C, GLY85C, HIS124C, HIS15A, ILE118A, ILE176C, ILE22A, ILE82C, ILE94A, LEU101A, LEU113C, LEU114A, LEU116C, LEU122C, LEU130C, LEU155C, LEU170C, LEU43C, LEU70A, LYS123C, LYS17A, LYS184C, LYS41C, LYS79C, MET18A, MET57A, PHE104C, PHE109A, PHE28A, PHE44C, PHE91A, PHE96A, PRO101C, PRO103A, PRO107C, PRO119A, PRO159C, PRO171C, PRO25A, PRO75A, SER106A, SER132C, SER172C, SER181C, SER74A, SER93A, THR102C, THR106C, THR108A, THR113A, THR116A, THR121C, THR129C, THR185C, THR20A, THR54A, THR56A, THR58A, THR60A, THR66A, THR98C, TRP102A, TRP10A, TRP158C, TRP96C, TYR105A, TYR110C, TYR122A, TYR187C, TYR53A, TYR59A, TYR72A, TYR92A, VAL115C, VAL125C, VAL126C, VAL127C, VAL156C, VAL174C, VAL178C, VAL68A, VAL71A, VAL86C, VAL88A, VAL95A, VAL97C
• A-E: ALA63A, ALA97A, ARG44A, ARG61A, ARG6E, ASP100A, ASP47A, ASP50A, GLN98A, GLU104A, GLU124A, GLU59E, GLU7E, GLU8E, GLY62A, HIS10E, HIS12E, ILE45A, ILE58E, ILE5E, LEU101A, LEU13E, LEU48A, LYS46A, LYS99A, MET57A, PHE96A, PRO103A, PRO57E, SER4E, THR58A, THR60A, THR64A, TRP102A, TYR105A, TYR59A, TYR60E, VAL16E, VAL9E
• A-F: ALA164F, ALA228F, ARG160F, ARG230F, ASP107A, GLN161F, GLN169F, GLU104A, GLU165F, GLY167F, LEU163F, LEU168F, LEU170F, LYS221F, LYS229F, PHE109A, PHE166F, PRO103A, PRO231F, SER106A, THR108A, TYR105A
• A-J: ASN84A, ASN84J, ASP11A, ASP11J, GLU85A, GLU86A, GLU86J, GLY83A, GLY83J, HIS14A, LYS7J, PHE82A, PRO8A, PRO8J, TRP10A, TRP10J, VAL9A, VAL9J
• A-K: ALA116K, ALA117K, ALA76A, ALA77A, ALA81A, ARG118K, ARG121A, ARG139K, ARG55A, ARG61A, ASN133K, ASN84A, ASN87A, ASP122K, ASP47A, ASP50A, ASP79A, GLN124K, GLU130K, GLU137K, GLU78A, GLU80A, GLU85A, GLU86A, GLU89A, GLY83A, HIS132K, ILE119K, ILE135K, LEU113K, LEU114K, LEU120K, LEU128K, LEU131K, LEU48A, LEU51A, LYS123K, LYS134K, LYS46A, LYS93K, MET106K, MET138K, PHE125K, PHE52A, PHE82A, PRO49A, PRO8A, THR115K, THR127K, THR129K, THR54A, TRP10A, TYR122A, TYR53A, VAL102K, VAL121K, VAL126K, VAL136K, VAL98K
• A-L: ALA33L, ASP26L, ILE29L, LEU30L, LEU51A, PHE52A, PRO49A, VAL34L
• B-C: ALA116B, ALA117B, ALA143B, ALA228C, ALA235C, ALA33C, ALA38C, ALA46C, ALA54B, ALA74B, ALA80B, ALA87B, ARG111B, ARG118B, ARG136C, ARG139B, ARG141B, ARG147C, ARG152C, ARG153C, ARG154C, ARG157C, ARG186C, ARG211C, ARG230C, ARG237C, ARG35C, ARG45B, ARG50C, ARG82B, ARG90B, ARG91B, ASN133B, ASN150C, ASN182C, ASN227C, ASN236C, ASN71B, ASN95B, ASP109C, ASP180C, ASP212C, ASP26C, ASP48C, ASP49B, ASP54C, ASP55B, CYS128C, CYS76B, CYS78B, CYS96B, GLN100B, GLN103C, GLN124B, GLN141C, GLN161C, GLN183C, GLN94B, GLU130B, GLU137B, GLU140B, GLU144C, GLU150B, GLU165C, GLU23C, GLU28C, GLU31C, GLU36C, GLU40C, GLU47C, GLU53B, GLU59B, GLU62B, GLU64B, GLU65B, GLU66B, GLU69B, GLU77B, GLU88B, GLU89B, GLY105B, GLY105C, GLY110B, GLY147B, GLY149B, GLY42C, GLY51B, GLY52B, GLY83B, HIS132B, HIS48B, HIS49C, HIS57C, HIS61B, ILE119B, ILE135B, ILE215C, ILE29C, ILE39C, ILE58B, ILE67B, LEU104B, LEU113B, LEU114B, LEU120B, LEU128B, LEU130C, LEU131B, LEU148B, LEU152B, LEU155C, LEU163C, LEU233C, LEU30C, LEU37C, LEU43C, LEU59C, LEU70B, LEU79B, LYS123B, LYS134B, LYS184C, LYS229C, LYS234C, LYS41C, LYS53C, LYS63B, MET106B, MET138B, MET32C, PHE104C, PHE125B, PHE166C, PHE27C, PHE44C, PHE73B, PRO100C, PRO101C, PRO107B, PRO107C, PRO137C, PRO143C, PRO149C, PRO153B, PRO231C, PRO238C, PRO47B, PRO57B, SER108C, SER132C, SER142C, SER148C, SER181C, SER25C, SER45C, THR102C, THR106C, THR115B, THR127B, THR129B, THR129C, THR72B, THR75B, THR86B, TRP112B, TRP145C, TRP158C, TRP52C, TRP68B, TRP81B, TRP85B, TYR103B, TYR108B, TYR109B, TYR110C, TYR134C, TYR146C, TYR151B, TYR151C, TYR55C, TYR60B, VAL121B, VAL126B, VAL127C, VAL136B, VAL142B, VAL156C, VAL162C, VAL217C, VAL232C, VAL239C, VAL24C, VAL34C, VAL46B, VAL50B, VAL51C, VAL56B, VAL56C, VAL84B
• B-D: ALA63D, ALA97D, ARG44D, ARG61D, ARG6B, ASP100D, ASP47D, ASP50D, GLN98D, GLU104D, GLU124D, GLU59B, GLU7B, GLU8B, GLY62D, HIS10B, HIS12B, ILE45D, ILE58B, ILE5B, LEU101D, LEU13B, LEU48D, LYS46D, LYS99D, MET57D, PHE96D, PRO103D, PRO57B, SER3B, SER4B, THR58D, THR60D, THR64D, TRP102D, TYR105D, TYR59D, TYR60B, VAL16B, VAL9B
• B-E: ALA17B, ALA17E, ALA22B, ALA22E, ALA42B, ALA42E, ALA54B, ALA54E, ARG11B, ARG11E, ARG41B, ARG41E, ARG45B, ARG45E, ARG6B, ARG6E, ASP49B, ASP49E, ASP55B, ASP55E, GLN100B, GLN100E, GLN20B, GLN20E, GLN25B, GLN25E, GLN26B, GLN26E, GLU53B, GLU53E, GLU7E, GLU8B, GLU8E, GLY105B, GLY105E, GLY14B, GLY14E, GLY51B, GLY51E, GLY52B, GLY52E, GLY99B, GLY99E, HIS10B, HIS10E, HIS12B, HIS12E, HIS24B, HIS24E, HIS28B, HIS28E, HIS37B, HIS37E, ILE35B, ILE35E, ILE58B, ILE58E, ILE5B, ILE5E, LEU104B, LEU104E, LEU13B, LEU13E, LEU18B, LEU18E, LEU23B, LEU23E, LEU39B, LEU39E, MET106B, MET106E, MET19B, MET19E, PHE40B, PHE40E, PRO21B, PRO21E, PRO47B, PRO47E, PRO57B, PRO57E, SER4B, SER4E, THR101B, THR101E, THR15B, THR15E, THR27B, THR27E, THR36B, THR36E, THR38B, THR38E, THR44B, THR44E, TYR103B, TYR103E, TYR43B, TYR43E, VAL102B, VAL102E, VAL16B, VAL16E, VAL46B, VAL46E, VAL50B, VAL50E, VAL56B, VAL56E, VAL9B, VAL9E
• B-F: ALA17B, ALA54B, ARG153F, ARG154F, ARG157F, ARG6B, ASN150F, ASP55B, GLN161F, GLN20B, GLU165F, GLU59B, GLY14B, HIS10B, ILE58B, LEU13B, MET19B, PRO149F, PRO21B, PRO57B, TRP158F, VAL162F, VAL16B, VAL56B, VAL9B
• B-H: ALA17B, ALA17H, ALA22B, ALA22H, ALA29B, ALA29H, ALA42B, ALA42H, ARG139B, ARG139H, GLN100B, GLN100H, GLN20B, GLN20H, GLN25B, GLN25H, GLN26B, GLN26H, GLU34B, GLU34H, GLU8B, GLU8H, GLY105B, GLY105H, HIS24B, HIS24H, HIS28B, HIS28H, ILE35B, ILE35H, LEU18B, LEU18H, LEU23B, LEU23H, LEU39B, LEU39H, MET106B, MET106H, MET19B, MET19H, PRO21B, PRO21H, PRO30B, PRO30H, THR101B, THR101H, THR27B, THR27H, THR36B, THR36H, TYR43B, TYR43H, VAL102B, VAL102H, VAL56B, VAL56H
• B-J: ALA116B, ALA117B, ALA76J, ALA77J, ALA81J, ARG118B, ARG121J, ARG139B, ARG55J, ARG61J, ASN133B, ASN84J, ASN87J, ASP122B, ASP47J, ASP50J, ASP79J, GLN124B, GLU130B, GLU137B, GLU140B, GLU78J, GLU80J, GLU85J, GLU86J, GLU89J, GLY83J, HIS132B, ILE119B, ILE135B, LEU113B, LEU114B, LEU120B, LEU128B, LEU131B, LEU48J, LEU51J, LYS123B, LYS134B, LYS46J, LYS93B, MET106B, MET138B, PHE125B, PHE52J, PHE82J, PRO49J, PRO8J, THR115B, THR127B, THR129B, THR54J, TRP10J, TYR122J, TYR53J, VAL102B, VAL121B, VAL126B, VAL136B, VAL98B
• B-K: ALA17B, ALA17K, ALA22B, ALA22K, ALA29B, ALA29K, ALA31B, ALA31K, ALA42B, ALA42K, ALA54B, ALA54K, ARG111B, ARG111K, ARG118B, ARG118K, ARG139B, ARG139K, ARG41B, ARG41K, ARG45B, ARG45K, ARG92B, ARG92K, ASP122B, ASP122K, ASP55B, ASP55K, ASP97B, ASP97K, CYS96B, CYS96K, GLN100B, GLN100K, GLN124B, GLN124K, GLN20B, GLN20K, GLN25B, GLN25K, GLN26B, GLN26K, GLU34B, GLU34K, GLU53B, GLU53K, GLU64B, GLU64K, GLU65B, GLU65K, GLU66B, GLU66K, GLU69B, GLU69K, GLU89B, GLU89K, GLY105B, GLY105K, GLY110B, GLY110K, GLY99B, GLY99K, HIS132B, HIS132K, HIS24B, HIS24K, HIS28B, HIS28K, HIS37B, HIS37K, HIS61B, HIS61K, ILE135B, ILE135K, ILE35B, ILE35K, ILE58B, ILE58K, LEU104B, LEU104K, LEU113B, LEU113K, LEU114B, LEU114K, LEU128B, LEU128K, LEU18B, LEU18K, LEU23B, LEU23K, LEU39B, LEU39K, LYS123B, LYS123K, LYS63B, LYS63K, LYS93B, LYS93K, MET106B, MET106K, MET19B, MET19K, PHE40B, PHE40K, PRO107B, PRO107K, PRO21B, PRO21K, PRO30B, PRO30K, PRO32B, PRO32K, PRO47B, PRO47K, THR101B, THR101K, THR15B, THR15K, THR27B, THR27K, THR33B, THR33K, THR36B, THR36K, THR44B, THR44K, TRP68B, TRP68K, TYR103B, TYR103K, TYR108B, TYR108K, TYR109B, TYR109K, TYR43B, TYR43K, VAL102B, VAL102K, VAL121B, VAL121K, VAL16B, VAL16K, VAL46B, VAL46K, VAL50K, VAL56B, VAL56K, VAL98B, VAL98K
• B-L: ALA235L, ALA29B, ALA31B, ARG147L, ARG152L, ARG153L, ARG237L, ARG41B, ASN150L, ASN236L, ASP26L, GLN26B, GLU144L, GLU28L, GLU31L, GLU34B, HIS28B, HIS37B, ILE29L, ILE35B, LEU233L, LEU30L, LEU39B, LYS234L, PHE27L, PHE40B, PRO149L, PRO30B, PRO32B, SER148L, SER25L, THR27B, THR33B, THR36B, THR38B, THR44B, TYR43B, VAL24L
• C-D: ALA164C, ALA228C, ARG160C, ARG230C, ASP107D, GLN161C, GLN169C, GLU104D, GLU165C, GLY167C, LEU163C, LEU168C, LEU170C, LYS221C, LYS229C, PHE109D, PHE166C, PRO103D, PRO231C, SER106D, THR108D, TYR105D
• C-E: ALA17E, ALA54E, ARG153C, ARG154C, ARG157C, ARG6E, ASN150C, ASP55E, GLN161C, GLN20E, GLU165C, GLU59E, GLY14E, HIS10E, ILE58E, LEU13E, MET19E, PRO149C, PRO21E, PRO57E, TRP158C, VAL162C, VAL16E, VAL56E, VAL9E
• C-F: ALA164C, ALA164F, ARG154C, ARG154F, ARG157C, ARG157F, ARG160C, ARG160F, GLN161C, GLN161F, GLN169C, GLN169F, GLU165C, GLU165F, GLU173C, GLU173F, GLY167C, GLY167F, ILE176C, ILE176F, LEU163C, LEU163F, LEU168C, LEU168F, LEU170C, LEU170F, PHE166C, PHE166F, PRO171C, PRO171F, SER172C, SER172F, TRP158C, TRP158F, VAL162C, VAL162F, VAL174C, VAL174F
• C-J: ALA33C, ASP26C, ILE29C, LEU30C, LEU51J, PHE52J, PRO49J, VAL34C
• C-K: ALA235C, ALA29K, ALA31K, ARG147C, ARG152C, ARG153C, ARG237C, ARG41K, ASN150C, ASN236C, ASP26C, GLN26K, GLU144C, GLU23C, GLU28C, GLU34K, HIS28K, HIS37K, ILE29C, ILE35K, LEU233C, LEU30C, LEU39K, LYS234C, PHE27C, PHE40K, PRO149C, PRO30K, PRO32K, SER148C, SER25C, THR27K, THR33K, THR36K, THR38K, THR44K, TYR43K, VAL24C
• D-E: ALA16D, ALA76D, ALA77D, ALA80E, ALA81D, ALA87E, ARG12D, ARG41E, ARG45E, ARG55D, ARG61D, ARG82E, ARG90E, ARG91E, ARG92E, ASN84D, ASN95E, ASP11D, ASP122E, ASP24D, ASP47D, ASP49E, ASP50D, ASP79D, ASP97E, CYS96E, GLN124E, GLN94E, GLU104D, GLU53E, GLU78D, GLU80D, GLU85D, GLU88E, GLU89E, GLY51E, GLY52E, GLY83D, GLY83E, HIS14D, HIS15D, HIS37E, HIS48E, ILE119E, LEU101D, LEU114D, LEU48D, LEU51D, LEU79E, LYS123E, LYS46D, LYS7D, LYS93E, MET57D, PHE125E, PHE28D, PHE40E, PHE52D, PHE82D, PHE91D, PRO47E, PRO49D, PRO75D, PRO8D, SER74D, THR127E, THR13D, THR20D, THR44E, THR54D, THR56D, THR58D, THR60D, THR86E, TRP102D, TRP10D, TRP81E, TRP85E, TYR43E, TYR53D, TYR59D, VAL46E, VAL50E, VAL84E, VAL9D
• D-F: ALA110D, ALA16D, ALA179F, ALA19D, ALA38F, ALA76D, ALA77D, ALA97D, ARG114F, ARG121D, ARG12D, ARG152F, ARG153F, ARG154F, ARG157F, ARG160F, ARG177F, ARG186F, ARG55D, ARG69D, ASN111D, ASN112F, ASN182F, ASN95F, ASP107D, ASP109F, ASP112D, ASP180F, ASP24D, ASP84F, CYS111F, CYS128F, CYS27D, CYS81F, GLN103F, GLN161F, GLN169F, GLN175F, GLN183F, GLN26D, GLN98D, GLU104D, GLU115D, GLU117D, GLU173F, GLU73D, GLU78D, GLU80D, GLU83F, GLU85D, GLU87F, GLY105F, GLY21D, GLY23D, GLY42F, GLY85F, HIS124F, HIS15D, ILE118D, ILE176F, ILE22D, ILE82F, ILE94D, LEU101D, LEU113F, LEU114D, LEU116F, LEU122F, LEU130F, LEU155F, LEU170F, LEU43F, LEU70D, LYS123F, LYS17D, LYS184F, LYS41F, LYS79F, LYS90F, MET18D, MET57D, PHE104F, PHE109D, PHE28D, PHE44F, PHE91D, PHE96D, PRO101F, PRO103D, PRO107F, PRO119D, PRO159F, PRO171F, PRO25D, PRO75D, SER106D, SER132F, SER172F, SER181F, SER74D, SER93D, THR102F, THR106F, THR108D, THR113D, THR116D, THR121F, THR129F, THR185F, THR20D, THR54D, THR56D, THR58D, THR60D, THR66D, THR98F, TRP102D, TRP10D, TRP158F, TRP96F, TYR105D, TYR110F, TYR122D, TYR187F, TYR53D, TYR59D, TYR72D, TYR92D, VAL115F, VAL125F, VAL126F, VAL127F, VAL156F, VAL174F, VAL178F, VAL68D, VAL71D, VAL86F, VAL88D, VAL95D, VAL97F
• D-G: ARG12D, ASN84D, ASN84G, ASP11D, ASP11G, GLU85D, GLU85G, GLU86D, GLU86G, GLY83D, GLY83G, HIS14D, HIS14G, LYS7D, LYS7G, PHE82D, PHE82G, PRO8D, PRO8G, THR13D, TRP10D, TRP10G, VAL9D, VAL9G
• D-H: ALA116H, ALA117H, ALA76D, ALA77D, ALA81D, ARG118H, ARG121D, ARG139H, ARG55D, ARG61D, ASN133H, ASN84D, ASN87D, ASP122H, ASP47D, ASP50D, ASP79D, GLN124H, GLU130H, GLU137H, GLU78D, GLU80D, GLU85D, GLU86D, GLU89D, GLY83D, HIS132H, ILE119H, ILE135H, LEU113H, LEU114H, LEU120H, LEU128H, LEU131H, LEU48D, LEU51D, LYS123H, LYS134H, LYS46D, LYS93H, MET106H, MET138H, PHE125H, PHE52D, PHE82D, PRO49D, PRO8D, THR115H, THR127H, THR129H, THR54D, TRP10D, TYR122D, TYR53D, VAL102H, VAL121H, VAL126H, VAL136H, VAL98H
• D-I: ALA33I, ASP26I, ILE29I, LEU30I, LEU51D, PHE52D, PRO49D, VAL34I
• E-F: ALA116E, ALA117E, ALA143E, ALA228F, ALA235F, ALA33F, ALA38F, ALA54E, ALA74E, ALA80E, ALA87E, ARG111E, ARG118E, ARG136F, ARG139E, ARG141E, ARG147F, ARG152F, ARG153F, ARG154F, ARG157F, ARG186F, ARG211F, ARG230F, ARG237F, ARG35F, ARG45E, ARG50F, ARG82E, ARG90E, ARG91E, ASN133E, ASN150F, ASN182F, ASN227F, ASN236F, ASN71E, ASN95E, ASP109F, ASP180F, ASP212F, ASP26F, ASP48F, ASP49E, ASP54F, ASP55E, CYS128F, CYS76E, CYS78E, CYS96E, GLN100E, GLN103F, GLN124E, GLN141F, GLN161F, GLN183F, GLN94E, GLU130E, GLU137E, GLU140E, GLU144F, GLU150E, GLU165F, GLU23F, GLU28F, GLU31F, GLU36F, GLU40F, GLU47F, GLU53E, GLU59E, GLU62E, GLU64E, GLU65E, GLU66E, GLU69E, GLU77E, GLU88E, GLU89E, GLY105E, GLY105F, GLY110E, GLY145E, GLY147E, GLY149E, GLY42F, GLY51E, GLY52E, GLY83E, HIS132E, HIS240F, HIS48E, HIS49F, HIS57F, HIS61E, ILE119E, ILE135E, ILE215F, ILE29F, ILE39F, ILE58E, ILE67E, LEU104E, LEU113E, LEU114E, LEU120E, LEU128E, LEU130F, LEU131E, LEU148E, LEU152E, LEU155F, LEU163F, LEU233F, LEU30F, LEU37F, LEU43F, LEU59F, LEU70E, LEU79E, LYS123E, LYS134E, LYS184F, LYS229F, LYS234F, LYS41F, LYS53F, LYS63E, MET106E, MET138E, MET32F, PHE104F, PHE125E, PHE166F, PHE27F, PHE44F, PHE73E, PRO100F, PRO101F, PRO107E, PRO107F, PRO137F, PRO143F, PRO149F, PRO153E, PRO231F, PRO238F, PRO47E, PRO57E, SER108F, SER132F, SER142F, SER148F, SER181F, SER25F, SER45F, THR102F, THR106F, THR115E, THR127E, THR129E, THR129F, THR72E, THR75E, THR86E, TRP112E, TRP145F, TRP158F, TRP52F, TRP68E, TRP81E, TRP85E, TYR103E, TYR108E, TYR109E, TYR110F, TYR134F, TYR146F, TYR151E, TYR151F, TYR55F, TYR60E, VAL102E, VAL121E, VAL126E, VAL127F, VAL136E, VAL142E, VAL156F, VAL162F, VAL217F, VAL232F, VAL239F, VAL24F, VAL34F, VAL46E, VAL50E, VAL51F, VAL56E, VAL56F, VAL84E
• E-G: ALA116E, ALA117E, ALA76G, ALA77G, ALA81G, ARG118E, ARG121G, ARG139E, ARG55G, ARG61G, ASN133E, ASN84G, ASN87G, ASP122E, ASP47G, ASP50G, ASP79G, GLN124E, GLU130E, GLU137E, GLU140E, GLU78G, GLU80G, GLU85G, GLU86G, GLU89G, GLY83G, HIS132E, ILE119E, ILE135E, LEU113E, LEU114E, LEU120E, LEU128E, LEU131E, LEU48G, LEU51G, LYS123E, LYS134E, LYS46G, LYS93E, MET106E, MET138E, PHE125E, PHE52G, PHE82G, PRO49G, PRO8G, THR115E, THR127E, THR129E, THR54G, TRP10G, TYR122G, TYR53G, VAL102E, VAL121E, VAL126E, VAL136E, VAL98E
• E-H: ALA17E, ALA17H, ALA22E, ALA22H, ALA29E, ALA29H, ALA31E, ALA31H, ALA42E, ALA42H, ALA54E, ALA54H, ARG111E, ARG111H, ARG118E, ARG118H, ARG139E, ARG139H, ARG41E, ARG41H, ARG45E, ARG45H, ARG92E, ARG92H, ASP122E, ASP122H, ASP55E, ASP55H, ASP97E, ASP97H, CYS96E, CYS96H, GLN100E, GLN100H, GLN124E, GLN124H, GLN20E, GLN20H, GLN25E, GLN25H, GLN26E, GLN26H, GLU34E, GLU34H, GLU53E, GLU53H, GLU64E, GLU64H, GLU65E, GLU65H, GLU66E, GLU66H, GLU69E, GLU69H, GLU89E, GLU89H, GLY105E, GLY105H, GLY110E, GLY110H, GLY99E, GLY99H, HIS132E, HIS132H, HIS24E, HIS24H, HIS28E, HIS28H, HIS37E, HIS37H, HIS61E, HIS61H, ILE135E, ILE135H, ILE35E, ILE35H, ILE58E, ILE58H, LEU104E, LEU104H, LEU113E, LEU113H, LEU114E, LEU114H, LEU128E, LEU128H, LEU18E, LEU18H, LEU23E, LEU23H, LEU39E, LEU39H, LYS123E, LYS123H, LYS63E, LYS63H, LYS93E, LYS93H, MET106E, MET106H, MET19E, MET19H, PHE40E, PHE40H, PRO107E, PRO107H, PRO21E, PRO21H, PRO30E, PRO30H, PRO32E, PRO32H, PRO47E, PRO47H, THR101E, THR101H, THR15E, THR15H, THR27E, THR27H, THR33E, THR33H, THR36E, THR36H, THR44E, THR44H, TRP68E, TRP68H, TYR103E, TYR103H, TYR108E, TYR108H, TYR109E, TYR109H, TYR43E, TYR43H, VAL102E, VAL102H, VAL121E, VAL121H, VAL16E, VAL16H, VAL46E, VAL46H, VAL56E, VAL56H, VAL98E, VAL98H
• E-I: ALA235I, ALA29E, ALA31E, ARG147I, ARG152I, ARG153I, ARG237I, ARG41E, ASN150I, ASN236I, ASP26I, GLN26E, GLU144I, GLU23I, GLU28I, GLU34E, HIS28E, HIS37E, ILE29I, ILE35E, LEU233I, LEU30I, LEU39E, LYS234I, PHE27I, PHE40E, PRO149I, PRO30E, PRO32E, SER148I, SER25I, THR27E, THR33E, THR36E, THR38E, THR44E, TYR43E, VAL24I
• E-K: ALA17E, ALA17K, ALA22E, ALA22K, ALA29E, ALA29K, ALA42E, ALA42K, ARG139E, ARG139K, GLN100E, GLN100K, GLN20E, GLN20K, GLN25E, GLN25K, GLN26E, GLN26K, GLU34E, GLU34K, GLU8E, GLU8K, GLY105E, GLY105K, HIS24E, HIS24K, HIS28E, HIS28K, ILE35E, ILE35K, LEU18E, LEU18K, LEU23E, LEU23K, LEU39E, LEU39K, MET106E, MET106K, MET19E, MET19K, PRO21E, PRO21K, PRO30E, PRO30K, THR101E, THR101K, THR27E, THR27K, THR36E, THR36K, TYR43E, TYR43K, VAL102E, VAL102K, VAL56E, VAL56K
• F-G: ALA33F, ASP26F, ILE29F, LEU30F, LEU51G, PHE52G, PRO49G, VAL34F
• F-H: ALA235F, ALA29H, ALA31H, ARG147F, ARG152F, ARG153F, ARG237F, ARG41H, ASN150F, ASN236F, ASP26F, GLN26H, GLU144F, GLU28F, GLU34H, HIS28H, HIS37H, ILE29F, ILE35H, LEU233F, LEU30F, LEU39H, LYS234F, PHE27F, PHE40H, PRO149F, PRO238F, PRO30H, PRO32H, SER148F, SER25F, THR27H, THR33H, THR36H, THR38H, THR44H, TYR43H, VAL24F
• G-H: ALA16G, ALA76G, ALA77G, ALA80H, ALA81G, ALA87H, ARG12G, ARG41H, ARG45H, ARG55G, ARG61G, ARG82H, ARG90H, ARG91H, ARG92H, ASN84G, ASN95H, ASP11G, ASP122H, ASP24G, ASP47G, ASP49H, ASP50G, ASP79G, ASP97H, CYS96H, GLN124H, GLN94H, GLU104G, GLU53H, GLU78G, GLU80G, GLU85G, GLU88H, GLU89H, GLY51H, GLY52H, GLY83G, GLY83H, HIS14G, HIS15G, HIS37H, HIS48H, ILE119H, LEU101G, LEU114G, LEU48G, LEU51G, LEU79H, LYS123H, LYS7G, LYS93H, MET57G, PHE125H, PHE28G, PHE40H, PHE52G, PHE82G, PHE91G, PRO47H, PRO49G, PRO75G, PRO8G, SER74G, THR13G, THR20G, THR44H, THR54G, THR56G, THR58G, THR60G, THR86H, TRP102G, TRP10G, TRP81H, TRP85H, TYR43H, TYR53G, TYR59G, VAL46H, VAL50H, VAL84H, VAL9G
• G-I: ALA110G, ALA16G, ALA179I, ALA19G, ALA38I, ALA76G, ALA77G, ALA97G, ARG114I, ARG121G, ARG12G, ARG152I, ARG153I, ARG154I, ARG157I, ARG160I, ARG177I, ARG186I, ARG55G, ARG69G, ASN111G, ASN112I, ASN182I, ASN95I, ASP107G, ASP109I, ASP112G, ASP180I, ASP24G, ASP84I, CYS111I, CYS128I, CYS27G, CYS81I, GLN103I, GLN161I, GLN169I, GLN175I, GLN183I, GLN26G, GLN98G, GLU104G, GLU115G, GLU117G, GLU173I, GLU73G, GLU78G, GLU80G, GLU83I, GLU85G, GLU87I, GLY105I, GLY21G, GLY23G, GLY42I, GLY85I, HIS124I, HIS15G, ILE118G, ILE176I, ILE22G, ILE82I, ILE94G, LEU101G, LEU113I, LEU114G, LEU116I, LEU122I, LEU130I, LEU155I, LEU170I, LEU43I, LEU70G, LYS123I, LYS17G, LYS184I, LYS41I, LYS79I, LYS90I, MET18G, MET57G, PHE104I, PHE109G, PHE28G, PHE44I, PHE91G, PHE96G, PRO101I, PRO103G, PRO107I, PRO119G, PRO159I, PRO171I, PRO25G, PRO75G, SER106G, SER132I, SER172I, SER181I, SER74G, SER93G, THR102I, THR106I, THR108G, THR113G, THR116G, THR121I, THR129I, THR13G, THR185I, THR20G, THR54G, THR56G, THR58G, THR60G, THR66G, THR98I, TRP102G, TRP10G, TRP158I, TRP96I, TYR105G, TYR110I, TYR122G, TYR187I, TYR53G, TYR59G, TYR72G, TYR92G, VAL115I, VAL125I, VAL126I, VAL127I, VAL156I, VAL174I, VAL178I, VAL68G, VAL71G, VAL86I, VAL88G, VAL95G, VAL97I
• G-K: ALA63G, ARG44G, ARG61G, ARG6K, ASP100G, ASP47G, ASP50G, GLN98G, GLU104G, GLU124G, GLU59K, GLU7K, GLU8K, GLY62G, HIS10K, HIS12K, ILE45G, ILE58K, ILE5K, LEU101G, LEU13K, LEU48G, LYS46G, LYS99G, MET57G, PHE96G, PRO103G, PRO57K, SER3K, SER4K, THR58G, THR60G, THR64G, TRP102G, TYR105G, TYR59G, TYR60K, VAL16K, VAL9K
• G-L: ALA164L, ALA228L, ARG160L, ARG230L, ASP107G, GLN161L, GLN169L, GLU104G, GLU165L, GLY167L, LEU163L, LEU168L, LEU170L, LYS221L, PHE109G, PHE166L, PRO103G, PRO231L, SER106G, THR108G, TYR105G
• H-I: ALA116H, ALA117H, ALA143H, ALA228I, ALA235I, ALA33I, ALA38I, ALA54H, ALA74H, ALA80H, ALA87H, ARG111H, ARG118H, ARG136I, ARG139H, ARG141H, ARG147I, ARG152I, ARG153I, ARG154I, ARG157I, ARG186I, ARG211I, ARG230I, ARG237I, ARG35I, ARG45H, ARG50I, ARG82H, ARG90H, ARG91H, ASN133H, ASN150I, ASN182I, ASN227I, ASN236I, ASN71H, ASN95H, ASP109I, ASP180I, ASP212I, ASP26I, ASP48I, ASP49H, ASP54I, ASP55H, CYS128I, CYS76H, CYS78H, CYS96H, GLN100H, GLN103I, GLN124H, GLN141I, GLN161I, GLN183I, GLN94H, GLU130H, GLU137H, GLU140H, GLU144I, GLU150H, GLU165I, GLU23I, GLU28I, GLU31I, GLU36I, GLU40I, GLU47I, GLU53H, GLU59H, GLU62H, GLU64H, GLU65H, GLU66H, GLU69H, GLU77H, GLU88H, GLU89H, GLY105H, GLY105I, GLY110H, GLY147H, GLY149H, GLY42I, GLY51H, GLY52H, GLY83H, HIS132H, HIS48H, HIS49I, HIS57I, HIS61H, ILE119H, ILE135H, ILE29I, ILE39I, ILE58H, ILE67H, LEU104H, LEU113H, LEU114H, LEU120H, LEU128H, LEU130I, LEU131H, LEU148H, LEU152H, LEU155I, LEU163I, LEU233I, LEU30I, LEU37I, LEU43I, LEU59I, LEU70H, LEU79H, LYS123H, LYS134H, LYS184I, LYS229I, LYS234I, LYS41I, LYS53I, LYS63H, MET106H, MET138H, MET32I, PHE104I, PHE125H, PHE166I, PHE27I, PHE44I, PHE73H, PRO100I, PRO101I, PRO107H, PRO107I, PRO137I, PRO143I, PRO149I, PRO153H, PRO231I, PRO238I, PRO47H, PRO57H, SER108I, SER132I, SER142I, SER148I, SER181I, SER25I, SER45I, THR102I, THR106I, THR115H, THR127H, THR129H, THR129I, THR72H, THR75H, THR86H, TRP112H, TRP145I, TRP158I, TRP52I, TRP68H, TRP81H, TRP85H, TYR103H, TYR108H, TYR109H, TYR110I, TYR134I, TYR146I, TYR151H, TYR151I, TYR55I, TYR60H, VAL102H, VAL121H, VAL126H, VAL127I, VAL136H, VAL142H, VAL156I, VAL162I, VAL217I, VAL232I, VAL239I, VAL24I, VAL34I, VAL46H, VAL50H, VAL51I, VAL56H, VAL56I, VAL84H
• H-J: ALA63J, ARG44J, ARG61J, ARG6H, ASP100J, ASP47J, ASP50J, GLN98J, GLU104J, GLU124J, GLU59H, GLU7H, GLU8H, GLY62J, HIS10H, HIS12H, ILE45J, ILE58H, ILE5H, LEU101J, LEU13H, LEU48J, LYS46J, LYS99J, MET57J, PHE96J, PRO103J, PRO57H, SER2H, SER3H, SER4H, THR58J, THR60J, THR64J, TRP102J, TYR105J, TYR59J, TYR60H, VAL16H, VAL9H
• H-K: ALA17H, ALA17K, ALA22H, ALA22K, ALA42H, ALA42K, ALA54H, ALA54K, ARG11H, ARG11K, ARG41H, ARG41K, ARG45H, ARG45K, ARG6H, ARG6K, ASP49H, ASP49K, ASP55H, ASP55K, GLN100H, GLN100K, GLN20H, GLN20K, GLN25H, GLN25K, GLN26H, GLN26K, GLU53H, GLU53K, GLU7H, GLU8H, GLU8K, GLY105H, GLY105K, GLY14H, GLY14K, GLY51H, GLY51K, GLY52H, GLY52K, GLY99H, GLY99K, HIS10H, HIS10K, HIS12H, HIS12K, HIS24H, HIS24K, HIS28H, HIS28K, HIS37H, HIS37K, ILE35H, ILE35K, ILE58H, ILE58K, ILE5H, ILE5K, LEU104H, LEU104K, LEU13H, LEU13K, LEU18H, LEU18K, LEU23H, LEU23K, LEU39H, LEU39K, MET106H, MET106K, MET19H, MET19K, PHE40H, PHE40K, PRO21H, PRO21K, PRO47H, PRO47K, PRO57H, PRO57K, SER4H, SER4K, THR101H, THR101K, THR15H, THR15K, THR27H, THR27K, THR36H, THR36K, THR38H, THR38K, THR44H, THR44K, TYR103H, TYR103K, TYR43H, TYR43K, VAL102H, VAL102K, VAL16H, VAL16K, VAL46H, VAL46K, VAL50H, VAL50K, VAL56H, VAL56K, VAL9H, VAL9K
• H-L: ALA17H, ALA54H, ARG153L, ARG154L, ARG157L, ARG6H, ASN150L, ASP55H, GLN161L, GLN20H, GLU165L, GLU59H, GLY14H, HIS10H, ILE58H, LEU13H, MET19H, PRO149L, PRO21H, PRO57H, TRP158L, VAL162L, VAL16H, VAL56H, VAL9H
• I-J: ALA164I, ALA228I, ARG160I, ARG230I, ASP107J, GLN161I, GLN169I, GLU104J, GLU165I, GLY167I, LEU163I, LEU168I, LEU170I, LYS221I, LYS229I, PHE109J, PHE166I, PRO103J, PRO231I, SER106J, THR108J, TYR105J, VAL219I
• I-K: ALA17K, ALA54K, ARG153I, ARG154I, ARG157I, ARG6K, ASN150I, ASP55K, GLN161I, GLN20K, GLU165I, GLU59K, GLY14K, HIS10K, ILE58K, LEU13K, MET19K, PRO149I, PRO21K, PRO57K, TRP158I, VAL156I, VAL162I, VAL16K, VAL56K, VAL9K
• I-L: ALA164I, ALA164L, ARG154I, ARG154L, ARG157I, ARG157L, ARG160I, ARG160L, GLN161I, GLN161L, GLN169I, GLN169L, GLU165I, GLU165L, GLU173I, GLU173L, GLY167I, GLY167L, ILE176I, ILE176L, LEU163I, LEU163L, LEU168I, LEU168L, LEU170I, LEU170L, LYS221L, PHE166I, PHE166L, PRO171I, PRO171L, SER172I, SER172L, TRP158I, TRP158L, VAL162I, VAL162L, VAL174I, VAL174L
• J-K: ALA16J, ALA76J, ALA77J, ALA80K, ALA81J, ALA87K, ARG12J, ARG41K, ARG45K, ARG55J, ARG61J, ARG82K, ARG90K, ARG91K, ARG92K, ASN84J, ASN95K, ASP11J, ASP122K, ASP24J, ASP47J, ASP49K, ASP50J, ASP79J, ASP97K, CYS96K, GLN124K, GLN94K, GLU104J, GLU53K, GLU78J, GLU80J, GLU85J, GLU88K, GLU89K, GLY51K, GLY52K, GLY83J, GLY83K, HIS14J, HIS15J, HIS37K, HIS48K, ILE119K, LEU101J, LEU114J, LEU48J, LEU51J, LEU79K, LYS123K, LYS7J, LYS93K, MET18J, MET57J, PHE125K, PHE28J, PHE40K, PHE52J, PHE82J, PHE91J, PRO47K, PRO49J, PRO75J, PRO8J, SER74J, THR127K, THR13J, THR20J, THR44K, THR54J, THR56J, THR58J, THR60J, THR86K, TRP102J, TRP10J, TRP81K, TRP85K, TYR43K, TYR53J, TYR59J, VAL126K, VAL46K, VAL50K, VAL84K, VAL9J
• J-L: ALA110J, ALA16J, ALA179L, ALA19J, ALA38L, ALA76J, ALA77J, ALA97J, ARG114L, ARG121J, ARG12J, ARG152L, ARG153L, ARG154L, ARG157L, ARG160L, ARG177L, ARG186L, ARG55J, ARG69J, ASN111J, ASN112L, ASN182L, ASN95L, ASP107J, ASP109L, ASP112J, ASP180L, ASP24J, ASP84L, CYS111L, CYS128L, CYS27J, CYS81L, GLN103L, GLN161L, GLN169L, GLN175L, GLN183L, GLN26J, GLN98J, GLU104J, GLU115J, GLU117J, GLU173L, GLU73J, GLU78J, GLU80J, GLU83L, GLU85J, GLU87L, GLY105L, GLY21J, GLY23J, GLY42L, GLY85L, HIS124L, HIS15J, ILE118J, ILE176L, ILE22J, ILE82L, ILE94J, LEU101J, LEU113L, LEU114J, LEU116L, LEU122L, LEU130L, LEU155L, LEU170L, LEU43L, LEU70J, LYS123L, LYS17J, LYS184L, LYS41L, LYS79L, LYS7J, LYS90L, MET18J, MET57J, PHE104L, PHE109J, PHE28J, PHE44L, PHE91J, PHE96J, PRO101L, PRO103J, PRO107L, PRO119J, PRO159L, PRO171L, PRO25J, PRO75J, SER106J, SER132L, SER172L, SER181L, SER74J, SER93J, THR102L, THR106L, THR108J, THR113J, THR116J, THR121L, THR129L, THR185L, THR20J, THR54J, THR56J, THR58J, THR60J, THR66J, THR98L, TRP102J, TRP10J, TRP158L, TRP96L, TYR105J, TYR110L, TYR122J, TYR187L, TYR53J, TYR59J, TYR72J, TYR92J, VAL115L, VAL125L, VAL126L, VAL127L, VAL156L, VAL174L, VAL178L, VAL68J, VAL71J, VAL86L, VAL88J, VAL95J, VAL97L
• K-L: ALA116K, ALA117K, ALA143K, ALA228L, ALA235L, ALA33L, ALA38L, ALA46L, ALA54K, ALA74K, ALA80K, ALA87K, ARG111K, ARG118K, ARG136L, ARG139K, ARG141K, ARG147L, ARG152L, ARG153L, ARG154L, ARG157L, ARG186L, ARG211L, ARG230L, ARG237L, ARG35L, ARG45K, ARG50L, ARG82K, ARG90K, ARG91K, ASN133K, ASN150L, ASN182L, ASN227L, ASN236L, ASN71K, ASN95K, ASP109L, ASP180L, ASP212L, ASP26L, ASP48L, ASP49K, ASP54L, ASP55K, CYS128L, CYS76K, CYS78K, CYS96K, GLN100K, GLN103L, GLN124K, GLN141L, GLN161L, GLN183L, GLN94K, GLU130K, GLU137K, GLU140K, GLU144L, GLU150K, GLU165L, GLU28L, GLU31L, GLU36L, GLU40L, GLU47L, GLU53K, GLU59K, GLU62K, GLU64K, GLU65K, GLU66K, GLU69K, GLU77K, GLU88K, GLU89K, GLY105K, GLY105L, GLY110K, GLY147K, GLY149K, GLY42L, GLY51K, GLY52K, GLY83K, HIS132K, HIS48K, HIS49L, HIS57L, HIS61K, ILE119K, ILE135K, ILE215L, ILE29L, ILE39L, ILE58K, ILE67K, LEU104K, LEU113K, LEU114K, LEU120K, LEU128K, LEU130L, LEU131K, LEU148K, LEU152K, LEU155L, LEU163L, LEU233L, LEU30L, LEU37L, LEU43L, LEU59L, LEU70K, LEU79K, LYS123K, LYS134K, LYS184L, LYS229L, LYS234L, LYS41L, LYS53L, LYS63K, MET106K, MET138K, MET32L, PHE104L, PHE125K, PHE166L, PHE27L, PHE44L, PHE73K, PRO100L, PRO101L, PRO107K, PRO107L, PRO137L, PRO143L, PRO149L, PRO153K, PRO231L, PRO238L, PRO47K, PRO57K, SER108L, SER132L, SER142L, SER148L, SER181L, SER25L, SER45L, THR102L, THR106L, THR115K, THR127K, THR129K, THR129L, THR72K, THR75K, THR86K, TRP112K, TRP145L, TRP158L, TRP52L, TRP68K, TRP81K, TRP85K, TYR103K, TYR108K, TYR109K, TYR110L, TYR134L, TYR146L, TYR151K, TYR151L, TYR55L, TYR60K, VAL121K, VAL126K, VAL127L, VAL136K, VAL142K, VAL156L, VAL162L, VAL217L, VAL232L, VAL239L, VAL24L, VAL34L, VAL46K, VAL50K, VAL51L, VAL56K, VAL56L, VAL84K