2ZU6

crystal structure of the eif4a-pdcd4 complex

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 198
  • Norm. En. per Res.: -4.0616
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-91.92	-191.2645	-447.475	-730.6595	194	31	2	16952	11	105	84
A-C	0.0	0.0	-0.6707	-0.6707	8	0	0	122	0	2	1
A-E	-21.9696	-45.5814	-23.6295	-91.1806	40	7	0	2207	2	10	11
B-C	-77.3565	-177.7738	-193.713	-448.8433	146	22	2	10054	17	69	78
B-D	-10.7312	-34.9643	-48.7574	-94.4529	39	4	0	2241	2	9	11
B-E	-5.4788	34.9762	-18.3149	11.1825	29	1	0	629	0	18	12
D-E	-122.4716	-232.9228	-448.801	-804.1955	198	54	2	17944	16	104	92
D-F	0.0	0.0	-4.8379	-4.8379	13	0	0	462	0	5	6
E-F	-68.593	-199.5915	-252.269	-520.4535	137	19	2	10328	15	58	61

Interface residues

• A-B: ALA107A, ALA113A, ALA163B, ALA185B, ALA208B, ALA214A, ALA251B, ALA257B, ALA333A, ARG110A, ARG161A, ARG168A, ARG189B, ARG190A, ARG216B, ARG233A, ARG256B, ARG282A, ARG283A, ARG334A, ARG353A, ARG359A, ARG385A, ARG403B, ARG407B, ASN139A, ASN182B, ASN280A, ASN325B, ASN352A, ASN355A, ASN392A, ASN410B, ASP164A, ASP180B, ASP185A, ASP190B, ASP194A, ASP219A, ASP246B, ASP253B, ASP330A, ASP348A, ASP386A, ASP399B, CYS134A, GLN114A, GLN173B, GLN195A, GLN321B, GLN322B, GLN400B, GLN75A, GLN77A, GLU111A, GLU143A, GLU165B, GLU174B, GLU177B, GLU183A, GLU183B, GLU186A, GLU186B, GLU210B, GLU239A, GLU240A, GLU244A, GLU249B, GLU348B, GLU354A, GLU355B, GLU362B, GLU388A, GLU406B, GLU411B, GLY136A, GLY137A, GLY157A, GLY160A, GLY179B, GLY191A, GLY211B, GLY318B, GLY319B, GLY320B, GLY361A, GLY404B, HIS178B, HIS215B, HIS303A, HIS326B, HIS349B, HIS358A, HIS358B, HIS360B, HIS361B, ILE135A, ILE171B, ILE172B, ILE279A, ILE357A, ILE387A, ILE396B, LEU112A, LEU168B, LEU188A, LEU188B, LEU191B, LEU203B, LEU207B, LEU209B, LEU221A, LEU235A, LEU241A, LEU243A, LEU247B, LEU250B, LEU252B, LEU260B, LEU327B, LEU331A, LEU332A, LEU354B, LEU390B, LYS118A, LYS166B, LYS193A, LYS212B, LYS225A, LYS237A, LYS242B, LYS284A, LYS352B, LYS392B, LYS402B, MET165A, MET187A, MET216A, PHE163A, PHE164B, PHE176B, PHE192A, PHE359B, PHE390A, PRO108A, PRO159A, PRO170B, PRO217A, PRO248B, PRO255B, PRO350A, PRO357B, SER189A, SER206B, SER213A, SER214B, SER218A, SER323B, SER345B, SER389B, SER393B, SER394B, THR109A, THR138A, THR158A, THR167B, THR169B, THR181B, THR215A, THR242A, THR254B, THR281A, THR328A, THR329A, THR351A, THR383A, THR389A, THR393A, THR395B, THR397B, TRP391B, TYR175B, TYR356A, TYR365B, TYR391A, VAL140A, VAL162A, VAL184B, VAL220A, VAL285A, VAL324B, VAL328B, VAL356B, VAL398B
• A-C: ALA142C, ARG141C, ARG385A, ASN139C, ASN392A, GLN145C, THR138C, THR389A
• A-E: ALA142A, ARG141A, ARG168A, ASN139A, ASP235E, ASP241E, ASP280E, CYS275E, GLN145A, GLN148A, GLU143A, GLU195E, GLU237E, GLY137A, GLY284E, ILE279E, LEU244E, LEU274E, LEU295E, LYS238E, LYS242E, LYS245E, LYS283E, MET149A, PHE240E, SER198E, SER232E, SER239E, SER281E, THR138A, THR233E, THR234E, THR277E, THR285E, TYR170A, TYR278E, TYR282E, VAL140A, VAL144A, VAL236E
• B-C: ALA107C, ALA113C, ALA294C, ALA301C, ALA333C, ALA347B, ARG110C, ARG161C, ARG168C, ARG190C, ARG282C, ARG283C, ARG295C, ARG334C, ARG353C, ARG359C, ARG407B, ASN139C, ASN280C, ASN325B, ASN352C, ASN355C, ASN416B, ASP164C, ASP286C, ASP296B, ASP296C, ASP305C, ASP307C, ASP312B, ASP330C, ASP332B, ASP343B, ASP348C, ASP414B, ASP418B, CYS134C, CYS350B, GLN114C, GLN115C, GLN195C, GLN259B, GLN263B, GLN308C, GLU111C, GLU186C, GLU290C, GLU310C, GLU330B, GLU337B, GLU346B, GLU348B, GLU353B, GLU354C, GLU362B, GLU366B, GLU373B, GLU411B, GLY136C, GLY137C, GLY157C, GLY160C, GLY191C, GLY304C, GLY316B, GLY342B, GLY376B, HIS293C, HIS303C, HIS326B, HIS349B, HIS358C, HIS361B, HIS421B, ILE135C, ILE279C, ILE331B, ILE369B, ILE415B, LEU188C, LEU301B, LEU331C, LEU332C, LEU334B, LEU335B, LEU339B, LEU340B, LEU349C, LEU351B, LEU354B, LEU372B, LEU417B, LYS118C, LYS193C, LYS284C, LYS291C, LYS297B, LYS306B, LYS311B, LYS329B, LYS336B, LYS352B, MET165C, MET187C, MET292C, MET306C, PHE163C, PHE192C, PHE359B, PRO108C, PRO159C, PRO350C, PRO413B, PRO420B, SER189C, SER303B, SER305B, SER313B, SER317B, SER341B, SER345B, SER374B, SER378B, SER422B, THR109C, THR138C, THR158C, THR281C, THR289C, THR298C, THR299B, THR329C, THR351C, THR375B, THR379B, TRP287C, TYR338B, TYR365B, VAL140C, VAL162C, VAL285C, VAL300B, VAL314B, VAL324B, VAL328B, VAL419B
• B-D: ALA142D, ARG141D, ARG168D, ASN139D, ASN276B, ASP235B, ASP241B, ASP280B, CYS275B, GLN145D, GLN148D, GLU143D, GLU195B, GLU237B, GLY137D, GLY284B, ILE279B, LEU244B, LEU274B, LEU295B, LYS238B, LYS242B, LYS245B, LYS283B, PHE240B, SER198B, SER239B, SER281B, THR138D, THR233B, THR234B, THR277B, THR285B, TYR170D, TYR278B, TYR282B, VAL140D, VAL144D, VAL236B
• B-E: ALA163B, ALA163E, ASP246B, ASP246E, ASP287B, ASP287E, CYS288B, CYS288E, GLU165B, GLU165E, GLU195B, GLU195E, GLU249B, GLU249E, GLY194B, GLY194E, LEU193B, LEU193E, LYS166B, LYS166E, LYS242B, LYS242E, LYS245B, LYS245E, PHE164B, PHE164E, THR167B, THR167E, VAL289E
• D-E: ALA107D, ALA113D, ALA185E, ALA208E, ALA214D, ALA251E, ALA257E, ALA333D, ARG110D, ARG161D, ARG168D, ARG189E, ARG190D, ARG216E, ARG233D, ARG256E, ARG282D, ARG283D, ARG334D, ARG353D, ARG359D, ARG382D, ARG385D, ARG403E, ARG407E, ASN139D, ASN182E, ASN280D, ASN325E, ASN352D, ASN355D, ASN392D, ASN410E, ASP164D, ASP180E, ASP185D, ASP190E, ASP194D, ASP219D, ASP246E, ASP253E, ASP330D, ASP348D, ASP386D, ASP399E, CYS134D, GLN173E, GLN195D, GLN259E, GLN321E, GLN322E, GLN400E, GLN75D, GLN77D, GLU111D, GLU165E, GLU174E, GLU177E, GLU183D, GLU183E, GLU186D, GLU186E, GLU210E, GLU239D, GLU240D, GLU244D, GLU249E, GLU348E, GLU354D, GLU355E, GLU362E, GLU388D, GLU406E, GLU411E, GLY136D, GLY137D, GLY157D, GLY160D, GLY179E, GLY191D, GLY211E, GLY304D, GLY318E, GLY319E, GLY320E, GLY364D, GLY404E, HIS178E, HIS215E, HIS303D, HIS326E, HIS349E, HIS358D, HIS358E, HIS360E, HIS361E, ILE135D, ILE171E, ILE172E, ILE196D, ILE279D, ILE331E, ILE357D, ILE387D, ILE396E, ILE408E, LEU112D, LEU188D, LEU188E, LEU191E, LEU203E, LEU207E, LEU209E, LEU221D, LEU235D, LEU241D, LEU243D, LEU250E, LEU252E, LEU260E, LEU327E, LEU331D, LEU332D, LEU349D, LEU354E, LEU390E, LYS118D, LYS166E, LYS193D, LYS212E, LYS225D, LYS237D, LYS238D, LYS242E, LYS284D, LYS352E, LYS392E, LYS402E, MET165D, MET187D, MET216D, PHE163D, PHE164E, PHE176E, PHE192D, PHE359E, PHE390D, PRO108D, PRO159D, PRO170E, PRO217D, PRO248E, PRO255E, PRO350D, PRO357E, SER189D, SER206E, SER213D, SER214E, SER218D, SER323E, SER345E, SER389E, SER393E, SER394E, SER78D, THR109D, THR138D, THR158D, THR167E, THR169E, THR215D, THR242D, THR254E, THR281D, THR328D, THR329D, THR351D, THR383D, THR389D, THR393D, THR395E, THR397E, TRP391E, TYR175E, TYR356D, TYR365E, TYR391D, VAL140D, VAL144D, VAL162D, VAL184E, VAL220D, VAL285D, VAL324E, VAL328E, VAL356E, VAL398E
• D-F: ALA142F, ARG141F, ARG385D, ASN139F, ASN392D, ASP386D, GLU388D, ILE395D, SER394D, THR138F, THR389D, THR393D, VAL140F
• E-F: ALA107F, ALA113F, ALA294F, ALA333F, ALA347E, ARG110F, ARG161F, ARG168F, ARG190F, ARG282F, ARG283F, ARG295F, ARG359F, ARG407E, ASN139F, ASN280F, ASN325E, ASN352F, ASN355F, ASN410E, ASN416E, ASP164F, ASP286F, ASP296E, ASP296F, ASP330F, ASP332E, ASP343E, ASP348F, ASP414E, ASP418E, CYS134F, CYS350E, GLN115F, GLN195F, GLN259E, GLN263E, GLU111F, GLU143F, GLU186F, GLU290F, GLU330E, GLU337E, GLU346E, GLU348E, GLU353E, GLU354F, GLU362E, GLU366E, GLU373E, GLU411E, GLY136F, GLY137F, GLY157F, GLY160F, GLY191F, GLY316E, GLY342E, HIS293F, HIS303F, HIS349E, HIS361E, HIS421E, ILE135F, ILE279F, ILE331E, ILE369E, ILE408E, ILE415E, LEU188F, LEU301E, LEU302E, LEU331F, LEU332F, LEU334E, LEU335E, LEU339E, LEU340E, LEU349F, LEU351E, LEU354E, LEU372E, LEU417E, LYS118F, LYS193F, LYS284F, LYS291F, LYS297E, LYS306E, LYS329E, LYS336E, LYS352E, LYS381E, MET165F, MET187F, MET292F, PHE163F, PHE192F, PHE278F, PRO108F, PRO159F, PRO350F, PRO413E, PRO420E, SER189F, SER303E, SER305E, SER313E, SER317E, SER341E, SER345E, SER374E, SER378E, SER422E, THR109F, THR138F, THR158F, THR281F, THR289F, THR298F, THR299E, THR329F, THR351F, THR375E, THR379E, TRP287F, TYR170F, TYR338E, TYR365E, VAL140F, VAL162F, VAL285F, VAL300E, VAL314E, VAL324E, VAL328E, VAL419E