2ZH0

crystal structure of ternary complex of hutp(hutp-l-his-zn)

• Total interactions analyzed: 66
• Total true interactions: 35
• Strongest Interaction:
  • Chains: D-N
  • Int. Res.: 127
  • Norm. En. per Res.: -4.2701
• Hub Node: C(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-C	-11.1165	13.5525	-150.08	-147.644	61	7	5	5611	1	16	17
B-D	-10.5823	14.1786	-142.461	-138.8646	60	10	5	5623	1	16	18
B-L	0.0	0.0	-0.1764	-0.1764	9	0	0	47	0	8	7
B-N	0.0	0.0	-0.3054	-0.3054	7	0	0	51	0	4	2
B-O	-59.4556	-1.8842	-186.052	-247.3918	67	13	2	6270	3	29	37
B-P	-61.2449	-55.3754	-348.783	-465.4032	120	13	10	14029	4	52	50
C-D	-3.666	17.664	-147.917	-133.9191	61	4	5	5491	0	15	18
C-J	0.0	0.0	-0.0066	-0.0066	3	0	0	8	0	1	1
C-L	0.0	0.0	-31.8636	-31.8636	38	0	0	2004	0	11	13
C-N	-65.0499	-4.3594	-192.495	-261.9043	67	12	1	7111	1	28	36
C-O	-80.3527	-70.7583	-355.852	-506.963	121	14	9	14067	4	61	54
C-P	0.0	0.0	-0.2194	-0.2194	4	0	0	36	0	4	2
D-N	-75.1725	-100.4115	-366.714	-542.298	127	15	9	14170	8	57	58
D-O	0.0	0.0	-0.2412	-0.2412	8	0	0	48	0	4	2
D-P	-79.2476	-10.1478	-197.565	-286.9604	69	14	0	6579	2	30	39
F-G	-10.4782	16.777	-146.346	-140.0471	60	8	5	5650	0	16	18
F-H	-7.0877	15.9834	-154.248	-145.3523	60	5	5	5732	0	15	19
F-J	0.0	0.0	-0.3241	-0.3241	8	0	0	54	0	4	2
F-K	-63.2216	-5.4223	-187.943	-256.5869	66	12	2	6153	3	29	36
F-L	-53.0837	-56.6647	-338.904	-448.6523	122	17	10	13841	6	54	49
G-H	-3.1335	16.3722	-145.692	-132.4532	59	4	5	5490	0	15	17
G-J	-71.9135	-5.3064	-181.603	-258.8229	68	12	1	6040	2	28	37
G-K	-53.6726	-61.3231	-343.391	-458.3866	121	15	10	13645	3	59	56
G-L	0.0	0.0	-0.2539	-0.2539	6	0	0	44	0	4	2
H-J	-75.2371	-99.0351	-364.882	-539.1543	128	20	10	14038	7	59	57
H-K	0.0	0.0	-0.3069	-0.3069	8	0	0	54	0	4	2
H-L	-90.6291	-4.4986	-195.142	-290.2697	70	14	0	6552	1	29	38
J-K	-9.957	15.0786	-143.939	-138.8174	59	9	5	5542	0	15	17
J-L	-10.6848	10.5246	-145.27	-145.4302	60	8	5	5521	1	15	17
J-O	0.0	0.0	-0.0075	-0.0075	2	0	0	5	0	0	0
K-L	-11.9169	19.1413	-152.145	-144.9206	59	10	5	5659	1	15	17
L-O	0.0	0.0	-5.8147	-5.8147	13	0	0	385	0	4	5
N-O	-10.0569	14.9928	-140.653	-135.7171	58	9	5	5508	0	16	16
N-P	-7.9699	12.2274	-145.473	-141.2155	58	8	4	5429	1	17	17
O-P	-12.1779	19.0836	-156.635	-149.7293	61	10	5	5735	1	16	17

Interface residues

• B-C: ALA131C, ALA47B, ALA52B, ALA53B, ARG70B, ARG88C, ARG98C, ASP46B, GLU137C, GLU139C, GLU55B, GLU67B, GLU71B, GLU90B, GLU90C, GLY130C, GLY135C, GLY68B, GLY89B, GLY89C, GLY94B, GLY94C, HIS138C, HIS48B, HIS73B, HIS77B, HIS84B, ILE129C, ILE133C, ILE51B, ILE54B, ILE64B, LEU136C, LEU83B, LEU92B, LEU92C, LEU93B, LEU93C, LEU96B, LEU96C, LEU97C, LYS49B, LYS59B, MET45B, MET45C, MET80B, MET91B, MET91C, PRO132C, SER66B, SER72B, SER95B, SER95C, THR56B, THR79B, THR87B, THR87C, THR99C, TYR69B, TYR76B, VAL50B
• B-D: ALA131B, ALA47D, ALA52D, ALA53D, ARG70D, ARG88B, ARG98B, ASP46D, GLN65D, GLU137B, GLU139B, GLU55D, GLU67D, GLU71D, GLU90B, GLU90D, GLY130B, GLY135B, GLY68D, GLY89B, GLY89D, GLY94B, HIS138B, HIS48D, HIS73D, HIS77D, HIS84D, ILE129B, ILE133B, ILE51D, ILE54D, ILE64D, LEU136B, LEU83D, LEU92B, LEU92D, LEU93B, LEU93D, LEU96B, LEU96D, LEU97B, LYS49D, LYS59D, MET45D, MET80D, MET91B, MET91D, PRO132B, SER66D, SER72D, SER95B, SER95D, THR56D, THR79D, THR87B, THR87D, THR99B, TYR69D, TYR76D, VAL50D
• B-L: GLU28L, GLU67B, GLY43L, GLY68B, LYS41L, LYS49B, LYS59B, SER66B, THR56B
• B-N: ARG88B, ARG88N, GLU90B, GLU90N, GLY89B, GLY89N, HIS84N
• B-O: ALA116B, ALA116O, ALA74B, ALA74O, ALA78B, ALA78O, ARG108B, ARG108O, ARG70B, ARG70O, ASN110B, ASN110O, ASN146B, ASN146O, ASP119B, ASP119O, GLN65B, GLN65O, GLU115B, GLU115O, GLU117B, GLU117O, GLU67B, GLU67O, GLU71B, GLU71O, GLU81B, GLU81O, GLY109O, GLY118B, GLY118O, GLY68B, GLY68O, HIS147B, HIS147O, HIS73B, HIS73O, HIS77B, HIS77O, HIS84B, HIS84O, ILE121B, ILE121O, ILE145B, ILE145O, ILE148B, ILE148O, LEU3B, LEU3O, LEU75B, LEU75O, PRO111B, PRO111O, SER114B, SER114O, SER72B, SER72O, THR2B, THR2O, TRP120B, TRP120O, TYR112B, TYR112O, TYR69B, TYR69O, TYR76B, TYR76O
• B-P: ALA122B, ALA122P, ALA78B, ALA78P, ALA82B, ALA82P, ARG103B, ARG103P, ARG11B, ARG11P, ARG7B, ARG7P, ARG88B, ARG88P, ARG8B, ARG8P, ARG98B, ASN146B, ASN146P, ASN19B, ASN19P, GLU117B, GLU117P, GLU137B, GLU137P, GLU139B, GLU139P, GLU20B, GLU20P, GLU81B, GLU81P, GLU90B, GLU90P, GLY10B, GLY10P, GLY127B, GLY127P, GLY135B, GLY135P, GLY142B, GLY142P, GLY144B, GLY144P, GLY85B, GLY85P, GLY89B, GLY89P, HIS138B, HIS138P, HIS147B, HIS147P, HIS4P, HIS77B, HIS77P, HIS84B, HIS84P, ILE121P, ILE129B, ILE129P, ILE145B, ILE145P, ILE9B, ILE9P, LEU125B, LEU125P, LEU12B, LEU12P, LEU136B, LEU136P, LEU15B, LEU15P, LEU16B, LEU16P, LEU17B, LEU17P, LEU18B, LEU18P, LEU3B, LEU3P, LEU83B, LEU83P, LYS134B, LYS134P, LYS5B, LYS5P, MET80B, MET80P, MET91B, MET91P, PHE141B, PHE141P, PRO111B, PRO111P, SER124B, SER124P, SER13B, SER13P, THR128B, THR128P, THR140B, THR140P, THR2B, THR2P, THR79B, THR87B, THR87P, TRP120B, TRP120P, TRP35B, TRP35P, TYR112B, TYR112P, TYR126B, TYR126P, VAL143B, VAL143P, VAL14B, VAL14P, VAL86B, VAL86P
• C-D: ALA131D, ALA47C, ALA52C, ALA53C, ARG70C, ARG88D, ARG98D, ASP46C, GLN65C, GLU137D, GLU139D, GLU55C, GLU67C, GLU71C, GLU90C, GLU90D, GLY130D, GLY135D, GLY68C, GLY89C, GLY89D, GLY94D, HIS138D, HIS48C, HIS73C, HIS77C, HIS84C, ILE129D, ILE133D, ILE51C, ILE54C, ILE64C, LEU136D, LEU83C, LEU92C, LEU92D, LEU93C, LEU93D, LEU96C, LEU96D, LEU97D, LYS134D, LYS49C, LYS59C, MET45C, MET80C, MET91C, MET91D, PRO132D, SER66C, SER72C, SER95C, SER95D, THR56C, THR79C, THR87C, THR87D, THR99D, TYR69C, TYR76C, VAL50C
• C-J: ARG103C, ILE133J, LYS41C
• C-L: ALA52L, ALA53L, ALA57L, ASP46C, GLU137C, GLY101C, GLY135C, GLY40L, GLY43C, GLY43L, GLY62L, ILE133C, ILE54L, LEU102C, LEU102L, LEU136C, LEU39L, LYS134C, LYS41C, LYS41L, LYS49C, LYS49L, LYS59L, LYS60L, MET45C, PHE104L, PRO132C, SER44C, SER44L, SER61L, SER66L, THR128C, THR56L, THR99C, VAL100C, VAL42C, VAL42L, VAL50L
• C-N: ALA116C, ALA116N, ALA74C, ALA74N, ALA78C, ALA78N, ARG108C, ARG108N, ARG70C, ARG70N, ASN110C, ASN110N, ASN146C, ASN146N, ASP119C, ASP119N, GLN65C, GLN65N, GLU117C, GLU117N, GLU67C, GLU67N, GLU71C, GLU71N, GLU81C, GLU81N, GLY109C, GLY109N, GLY118C, GLY118N, GLY68C, GLY68N, HIS147C, HIS147N, HIS73C, HIS73N, HIS77C, HIS77N, HIS84C, HIS84N, ILE121C, ILE121N, ILE145C, ILE145N, ILE148C, ILE148N, LEU3C, LEU3N, LEU75C, LEU75N, MET80N, PRO111C, PRO111N, SER114C, SER114N, SER72C, SER72N, THR2C, THR2N, TRP120C, TRP120N, TYR112C, TYR112N, TYR69C, TYR69N, TYR76C, TYR76N
• C-O: ALA122C, ALA122O, ALA21C, ALA21O, ALA78C, ALA78O, ALA82C, ALA82O, ARG103C, ARG103O, ARG11C, ARG11O, ARG7C, ARG7O, ARG88C, ARG88O, ARG8C, ARG8O, ARG98C, ARG98O, ASN146C, ASN146O, ASN19C, ASN19O, GLU117C, GLU117O, GLU137C, GLU137O, GLU139C, GLU139O, GLU20C, GLU20O, GLU81C, GLU81O, GLU90C, GLU90O, GLY10C, GLY10O, GLY127C, GLY127O, GLY130O, GLY135C, GLY135O, GLY142C, GLY142O, GLY144C, GLY144O, GLY85C, GLY85O, GLY89C, GLY89O, HIS138C, HIS138O, HIS147C, HIS147O, HIS4O, HIS77C, HIS77O, HIS84C, HIS84O, ILE121O, ILE129C, ILE129O, ILE145C, ILE145O, ILE9C, ILE9O, LEU125C, LEU125O, LEU12C, LEU12O, LEU136C, LEU136O, LEU15C, LEU15O, LEU16C, LEU16O, LEU17C, LEU17O, LEU18C, LEU18O, LEU3C, LEU3O, LEU83C, LEU83O, LYS134C, LYS134O, LYS5C, LYS5O, MET80C, MET80O, MET91C, MET91O, PHE141C, PHE141O, PRO111C, PRO111O, SER124C, SER124O, SER13C, SER13O, THR128C, THR128O, THR140C, THR140O, THR2C, THR2O, THR87C, THR87O, TRP120C, TRP120O, TYR112C, TYR112O, TYR126C, TYR126O, VAL143C, VAL143O, VAL14C, VAL14O, VAL86C, VAL86O
• C-P: GLU90C, GLU90P, GLY89C, GLY89P
• D-N: ALA122D, ALA122N, ALA21N, ALA78D, ALA78N, ALA82D, ALA82N, ARG103D, ARG103N, ARG11D, ARG11N, ARG7D, ARG7N, ARG88D, ARG88N, ARG8D, ARG8N, ARG98D, ARG98N, ASN146D, ASN146N, ASN19D, ASN19N, GLU113N, GLU117D, GLU117N, GLU137D, GLU137N, GLU139D, GLU139N, GLU20D, GLU20N, GLU81D, GLU81N, GLU90D, GLU90N, GLY101N, GLY10D, GLY10N, GLY127D, GLY127N, GLY130D, GLY135D, GLY135N, GLY142D, GLY142N, GLY144D, GLY144N, GLY85D, GLY85N, GLY89D, GLY89N, HIS138D, HIS138N, HIS147D, HIS147N, HIS4D, HIS4N, HIS77D, HIS77N, HIS84D, HIS84N, ILE121D, ILE129D, ILE129N, ILE133N, ILE145D, ILE145N, ILE9D, ILE9N, LEU125D, LEU125N, LEU12D, LEU12N, LEU136D, LEU136N, LEU15D, LEU15N, LEU16D, LEU16N, LEU17D, LEU17N, LEU18D, LEU18N, LEU3D, LEU3N, LEU83D, LEU83N, LYS134D, LYS134N, LYS41D, LYS5D, LYS5N, MET80D, MET80N, MET91D, MET91N, PHE141D, PHE141N, PRO111D, PRO111N, SER124D, SER124N, SER13D, SER13N, THR128D, THR128N, THR140D, THR140N, THR2D, THR2N, THR87D, THR87N, TRP120D, TRP120N, TRP35D, TRP35N, TYR112D, TYR112N, TYR126D, TYR126N, VAL143D, VAL143N, VAL14D, VAL14N, VAL86D, VAL86N
• D-O: ARG88D, ARG88O, GLU90D, GLU90O, GLY89D, GLY89O, HIS84D, HIS84O
• D-P: ALA116D, ALA116P, ALA74D, ALA74P, ALA78D, ALA78P, ARG108D, ARG108P, ARG70D, ARG70P, ASN110D, ASN110P, ASN146D, ASN146P, ASP119D, ASP119P, GLN65D, GLN65P, GLU115D, GLU115P, GLU117D, GLU117P, GLU67D, GLU67P, GLU71D, GLU71P, GLU81D, GLU81P, GLY109D, GLY109P, GLY118D, GLY118P, GLY68D, GLY68P, HIS147D, HIS147P, HIS73D, HIS73P, HIS77D, HIS77P, HIS84D, HIS84P, ILE121D, ILE121P, ILE145D, ILE145P, ILE148D, ILE148P, LEU3D, LEU3P, LEU75D, LEU75P, MET80P, PRO111D, PRO111P, SER114D, SER114P, SER72D, SER72P, THR2D, THR2P, TRP120D, TRP120P, TYR112D, TYR112P, TYR69D, TYR69P, TYR76D, TYR76P
• F-G: ALA131G, ALA47F, ALA52F, ALA53F, ARG70F, ARG88G, ARG98G, ASP46F, GLU137G, GLU139G, GLU55F, GLU67F, GLU71F, GLU90F, GLU90G, GLY130G, GLY135G, GLY68F, GLY89F, GLY89G, GLY94F, GLY94G, HIS138G, HIS48F, HIS73F, HIS77F, HIS84F, ILE129G, ILE133G, ILE51F, ILE54F, ILE64F, LEU136G, LEU83F, LEU92F, LEU92G, LEU93F, LEU93G, LEU96F, LEU96G, LEU97G, LYS49F, LYS59F, MET45F, MET80F, MET91F, MET91G, PRO132G, SER66F, SER72F, SER95F, SER95G, THR56F, THR79F, THR87F, THR87G, THR99G, TYR69F, TYR76F, VAL50F
• F-H: ALA131F, ALA47H, ALA52H, ALA53H, ARG70H, ARG88F, ARG98F, ASP46H, GLN65H, GLU137F, GLU139F, GLU55H, GLU67H, GLU71H, GLU90F, GLU90H, GLY130F, GLY135F, GLY68H, GLY89F, GLY89H, GLY94F, HIS138F, HIS48H, HIS73H, HIS77H, HIS84H, ILE129F, ILE133F, ILE51H, ILE54H, ILE64H, LEU136F, LEU83H, LEU92F, LEU92H, LEU93F, LEU93H, LEU96F, LEU96H, LEU97F, LYS49H, LYS59H, MET45H, MET80H, MET91F, MET91H, PRO132F, SER66H, SER72H, SER95F, SER95H, THR56H, THR79H, THR87F, THR87H, THR99F, TYR69H, TYR76H, VAL50H
• F-J: ARG88F, ARG88J, GLU90F, GLU90J, GLY89F, GLY89J, HIS84F, HIS84J
• F-K: ALA116F, ALA116K, ALA74F, ALA74K, ALA78F, ALA78K, ARG108F, ARG108K, ARG70F, ARG70K, ASN110F, ASN110K, ASN146F, ASN146K, ASP119F, ASP119K, GLN65F, GLN65K, GLU115F, GLU115K, GLU117F, GLU117K, GLU67F, GLU67K, GLU71F, GLU71K, GLU81F, GLU81K, GLY118F, GLY118K, GLY68F, GLY68K, HIS147F, HIS147K, HIS73F, HIS73K, HIS77F, HIS77K, HIS84F, HIS84K, ILE121F, ILE121K, ILE145F, ILE145K, ILE148F, ILE148K, LEU3F, LEU3K, LEU75F, LEU75K, PRO111F, PRO111K, SER114F, SER114K, SER72F, SER72K, THR2F, THR2K, TRP120F, TRP120K, TYR112F, TYR112K, TYR69F, TYR69K, TYR76F, TYR76K
• F-L: ALA122F, ALA122L, ALA21F, ALA78F, ALA78L, ALA82F, ALA82L, ARG103F, ARG103L, ARG11F, ARG11L, ARG7F, ARG7L, ARG88F, ARG88L, ARG8F, ARG8L, ARG98F, ARG98L, ASN146F, ASN146L, ASN19F, ASN19L, GLU117F, GLU117L, GLU137F, GLU137L, GLU139F, GLU139L, GLU20F, GLU20L, GLU6L, GLU81F, GLU81L, GLU90F, GLU90L, GLY10F, GLY10L, GLY127F, GLY127L, GLY135F, GLY135L, GLY142F, GLY142L, GLY144F, GLY144L, GLY85F, GLY85L, GLY89F, GLY89L, HIS138F, HIS138L, HIS147F, HIS147L, HIS4L, HIS77F, HIS77L, HIS84F, HIS84L, ILE121L, ILE129F, ILE129L, ILE145F, ILE145L, ILE9F, ILE9L, LEU125F, LEU125L, LEU12F, LEU12L, LEU136F, LEU136L, LEU15F, LEU15L, LEU16F, LEU16L, LEU17F, LEU17L, LEU18F, LEU18L, LEU3F, LEU3L, LEU83F, LEU83L, LYS134F, LYS134L, LYS41L, LYS5F, LYS5L, MET80F, MET80L, MET91L, PHE141F, PHE141L, PRO111F, PRO111L, SER124F, SER124L, SER13F, SER13L, THR128F, THR128L, THR140F, THR140L, THR2F, THR2L, THR87F, THR87L, TRP120F, TRP120L, TRP35F, TRP35L, TYR112F, TYR112L, TYR126F, TYR126L, VAL143F, VAL143L, VAL14F, VAL14L, VAL86F, VAL86L
• G-H: ALA131H, ALA47G, ALA52G, ALA53G, ARG70G, ARG88H, ARG98H, ASP46G, GLU137H, GLU139H, GLU55G, GLU67G, GLU71G, GLU90G, GLU90H, GLY130H, GLY135H, GLY68G, GLY89G, GLY89H, GLY94G, GLY94H, HIS138H, HIS48G, HIS73G, HIS77G, HIS84G, ILE129H, ILE133H, ILE51G, ILE54G, LEU136H, LEU83G, LEU92G, LEU92H, LEU93G, LEU93H, LEU96G, LEU96H, LEU97H, LYS49G, LYS59G, MET45G, MET80G, MET91G, MET91H, PRO132H, SER66G, SER72G, SER95G, SER95H, THR56G, THR79G, THR87G, THR87H, THR99H, TYR69G, TYR76G, VAL50G
• G-J: ALA116G, ALA116J, ALA74G, ALA74J, ALA78G, ALA78J, ARG108G, ARG108J, ARG70G, ARG70J, ASN110G, ASN110J, ASN146G, ASN146J, ASP119G, ASP119J, GLN65G, GLN65J, GLU115G, GLU115J, GLU117G, GLU117J, GLU67G, GLU67J, GLU71G, GLU71J, GLU81G, GLU81J, GLY109G, GLY118G, GLY118J, GLY68G, GLY68J, HIS147G, HIS147J, HIS73G, HIS73J, HIS77G, HIS77J, HIS84G, HIS84J, ILE121G, ILE121J, ILE145G, ILE145J, ILE148G, ILE148J, LEU3G, LEU3J, LEU75G, LEU75J, MET80G, PRO111G, PRO111J, SER114G, SER114J, SER72G, SER72J, THR2G, THR2J, TRP120G, TRP120J, TYR112G, TYR112J, TYR69G, TYR69J, TYR76G, TYR76J
• G-K: ALA122G, ALA122K, ALA21G, ALA21K, ALA78G, ALA78K, ALA82G, ALA82K, ARG103G, ARG103K, ARG11G, ARG11K, ARG7G, ARG7K, ARG88G, ARG88K, ARG8G, ARG8K, ARG98G, ARG98K, ASN146G, ASN146K, ASN19G, ASN19K, GLU117G, GLU117K, GLU137G, GLU137K, GLU139G, GLU139K, GLU20G, GLU20K, GLU81G, GLU81K, GLU90G, GLU90K, GLY10G, GLY10K, GLY127G, GLY127K, GLY135G, GLY135K, GLY142G, GLY142K, GLY144G, GLY144K, GLY85G, GLY85K, GLY89G, GLY89K, HIS138G, HIS138K, HIS147G, HIS147K, HIS4K, HIS77G, HIS77K, HIS84G, HIS84K, ILE129G, ILE129K, ILE145G, ILE145K, ILE9G, ILE9K, LEU107G, LEU125G, LEU12G, LEU12K, LEU136G, LEU136K, LEU15G, LEU15K, LEU16G, LEU16K, LEU17G, LEU17K, LEU18G, LEU18K, LEU3G, LEU3K, LEU83G, LEU83K, LYS134G, LYS134K, LYS5G, LYS5K, MET80G, MET80K, MET91G, MET91K, PHE141G, PHE141K, PRO111G, PRO111K, SER124G, SER124K, SER13G, SER13K, THR128G, THR128K, THR140G, THR140K, THR2G, THR2K, THR87G, THR87K, TRP120G, TRP120K, TRP35G, TRP35K, TYR112G, TYR112K, TYR126G, TYR126K, VAL143G, VAL143K, VAL14G, VAL14K, VAL86G, VAL86K
• G-L: ARG88G, ARG88L, GLU90G, GLU90L, GLY89G, GLY89L
• H-J: ALA122H, ALA122J, ALA21J, ALA78H, ALA78J, ALA82H, ALA82J, ARG103H, ARG103J, ARG11H, ARG11J, ARG7H, ARG7J, ARG88H, ARG88J, ARG8H, ARG8J, ARG98H, ARG98J, ASN146H, ASN146J, ASN19H, ASN19J, GLU117H, GLU117J, GLU137H, GLU137J, GLU139H, GLU139J, GLU20H, GLU20J, GLU6H, GLU81H, GLU81J, GLU90H, GLU90J, GLY101H, GLY10H, GLY10J, GLY127H, GLY127J, GLY130H, GLY135H, GLY135J, GLY142H, GLY142J, GLY144H, GLY144J, GLY85H, GLY85J, GLY89H, GLY89J, HIS138H, HIS138J, HIS147H, HIS147J, HIS4H, HIS4J, HIS77H, HIS77J, HIS84H, HIS84J, ILE121H, ILE121J, ILE129H, ILE129J, ILE133J, ILE145H, ILE145J, ILE9H, ILE9J, LEU102H, LEU125H, LEU125J, LEU12H, LEU12J, LEU136H, LEU136J, LEU15H, LEU15J, LEU16H, LEU16J, LEU17H, LEU17J, LEU18H, LEU18J, LEU3H, LEU3J, LEU83H, LEU83J, LYS134H, LYS134J, LYS5H, LYS5J, MET80H, MET80J, MET91H, MET91J, PHE141H, PHE141J, PRO111H, PRO111J, SER124H, SER124J, SER13H, SER13J, THR128H, THR128J, THR140H, THR140J, THR2H, THR2J, THR87H, THR87J, TRP120H, TRP120J, TRP35H, TRP35J, TYR112H, TYR112J, TYR126H, TYR126J, VAL143H, VAL143J, VAL14H, VAL14J, VAL86H, VAL86J
• H-K: ARG88H, ARG88K, GLU90H, GLU90K, GLY89H, GLY89K, HIS84H, HIS84K
• H-L: ALA116H, ALA116L, ALA74H, ALA74L, ALA78H, ALA78L, ARG108H, ARG108L, ARG70H, ARG70L, ASN110H, ASN110L, ASN146H, ASN146L, ASP119H, ASP119L, GLN65H, GLN65L, GLU115H, GLU115L, GLU117H, GLU117L, GLU67H, GLU67L, GLU71H, GLU71L, GLU81H, GLU81L, GLY109H, GLY109L, GLY118H, GLY118L, GLY68H, GLY68L, HIS147H, HIS147L, HIS73H, HIS73L, HIS77H, HIS77L, HIS84H, HIS84L, ILE121H, ILE121L, ILE145H, ILE145L, ILE148H, ILE148L, LEU3H, LEU3L, LEU75H, LEU75L, MET80H, MET80L, PRO111H, PRO111L, SER114H, SER114L, SER72H, SER72L, THR2H, THR2L, TRP120H, TRP120L, TYR112H, TYR112L, TYR69H, TYR69L, TYR76H, TYR76L
• J-K: ALA131K, ALA47J, ALA52J, ALA53J, ARG70J, ARG88K, ARG98K, ASP46J, GLU137K, GLU139K, GLU55J, GLU67J, GLU71J, GLU90J, GLU90K, GLY130K, GLY135K, GLY68J, GLY89J, GLY89K, GLY94K, HIS138K, HIS48J, HIS73J, HIS77J, HIS84J, ILE129K, ILE133K, ILE51J, ILE54J, LEU136K, LEU83J, LEU92J, LEU92K, LEU93J, LEU93K, LEU96J, LEU96K, LEU97K, LYS49J, LYS59J, MET45K, MET80J, MET91J, MET91K, PRO132K, SER66J, SER72J, SER95J, SER95K, THR128K, THR56J, THR79J, THR87J, THR87K, THR99K, TYR69J, TYR76J, VAL50J
• J-L: ALA131J, ALA47L, ALA52L, ALA53L, ARG70L, ARG88J, ARG98J, ASP46L, GLN65L, GLU137J, GLU139J, GLU55L, GLU67L, GLU90J, GLU90L, GLY130J, GLY135J, GLY68L, GLY89J, GLY89L, GLY94J, HIS138J, HIS48L, HIS73L, HIS77L, HIS84L, ILE129J, ILE133J, ILE51L, ILE54L, ILE64L, LEU136J, LEU83L, LEU92J, LEU92L, LEU93J, LEU93L, LEU96J, LEU96L, LEU97J, LYS134J, LYS49L, LYS59L, MET80L, MET91J, MET91L, PRO132J, SER66L, SER72L, SER95J, SER95L, THR128J, THR56L, THR79L, THR87J, THR87L, THR99J, TYR69L, TYR76L, VAL50L
• J-O: HIS4O, MET45J
• K-L: ALA131L, ALA47K, ALA52K, ALA53K, ARG70K, ARG88L, ARG98L, ASP46K, GLU137L, GLU139L, GLU55K, GLU67K, GLU71K, GLU90K, GLU90L, GLY130L, GLY135L, GLY68K, GLY89K, GLY89L, GLY94L, HIS138L, HIS48K, HIS73K, HIS77K, HIS84K, ILE129L, ILE133L, ILE51K, ILE54K, ILE64K, LEU136L, LEU83K, LEU92K, LEU92L, LEU93K, LEU93L, LEU96K, LEU96L, LEU97L, LYS49K, LYS59K, MET80K, MET91K, MET91L, PRO132L, SER66K, SER72K, SER95K, SER95L, THR128L, THR56K, THR79K, THR87K, THR87L, THR99L, TYR69K, TYR76K, VAL50K
• L-O: ARG7O, ASP46L, GLU113O, GLY43L, HIS48L, HIS4O, LEU3O, LYS49L, MET45L, SER114O, SER44L, THR2O, VAL42L
• N-O: ALA131O, ALA47N, ALA52N, ALA53N, ARG70N, ARG88O, ARG98O, ASP46N, GLU137O, GLU139O, GLU55N, GLU67N, GLU71N, GLU90N, GLU90O, GLY130O, GLY135O, GLY68N, GLY89N, GLY89O, GLY94O, HIS138O, HIS48N, HIS73N, HIS77N, HIS84N, ILE129O, ILE133O, ILE51N, LEU136O, LEU83N, LEU92N, LEU92O, LEU93N, LEU93O, LEU96N, LEU96O, LEU97O, LYS49N, LYS59N, MET45O, MET80N, MET91N, MET91O, PRO132O, SER66N, SER72N, SER95N, SER95O, THR128O, THR56N, THR79N, THR87N, THR87O, THR99O, TYR69N, TYR76N, VAL50N
• N-P: ALA131N, ALA47P, ALA52P, ALA53P, ARG70P, ARG88N, ARG98N, ASP46P, GLU137N, GLU139N, GLU55P, GLU67P, GLU71P, GLU90N, GLU90P, GLY130N, GLY135N, GLY68P, GLY89N, GLY89P, GLY94N, HIS138N, HIS48P, HIS73P, HIS77P, HIS84P, ILE129N, ILE133N, ILE51P, ILE54P, LEU136N, LEU83P, LEU92N, LEU92P, LEU93N, LEU93P, LEU96N, LEU96P, LEU97N, LYS49P, LYS59P, MET80P, MET91N, MET91P, PRO132N, SER66P, SER72P, SER95N, SER95P, THR128N, THR56P, THR79P, THR87N, THR87P, THR99N, TYR69P, TYR76P, VAL50P
• O-P: ALA131P, ALA47O, ALA52O, ALA53O, ARG70O, ARG88P, ARG98P, ASP46O, GLN65O, GLU137P, GLU139P, GLU55O, GLU67O, GLU71O, GLU90O, GLU90P, GLY130P, GLY135P, GLY68O, GLY89O, GLY89P, GLY94P, HIS138P, HIS48O, HIS73O, HIS77O, HIS84O, ILE129P, ILE133P, ILE51O, ILE54O, ILE64O, LEU136P, LEU83O, LEU92O, LEU92P, LEU93O, LEU93P, LEU96O, LEU96P, LEU97P, LYS49O, LYS59O, MET45P, MET80O, MET91O, MET91P, PRO132P, SER66O, SER72O, SER95O, SER95P, THR128P, THR56O, THR79O, THR87O, THR87P, THR99P, TYR69O, TYR76O, VAL50O