2Z3A

crystal structure of bacillus subtilis codw, a non- canonical hslv-like peptidase with an impaired catalytic apparatus

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: C-L
  • Int. Res.: 50
  • Norm. En. per Res.: -3.8681
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.7302	-38.31	-193.597	-261.6371	94	14	5	8554	3	26	25
A-F	-25.5151	-14.5164	-193.062	-233.0935	91	9	8	8743	2	30	26
A-G	-6.6983	-43.9378	-170.611	-221.2471	68	9	20	7676	1	26	24
A-H	-33.4278	-12.5225	-137.099	-183.0493	49	8	13	5253	0	6	3
B-C	-14.0224	-10.8791	-165.413	-190.3145	89	6	7	8113	1	30	28
B-G	-10.3122	0.0	-115.558	-125.8702	47	6	13	4653	0	6	3
B-L	-8.0511	-40.6088	-143.997	-192.657	62	8	18	6882	1	26	24
C-D	-16.5678	-28.0478	-152.278	-196.8936	89	4	5	7688	2	28	25
C-K	-7.1225	-49.7186	-173.467	-230.3081	68	7	21	7734	2	26	25
C-L	-39.7787	-13.6276	-139.998	-193.4044	50	12	13	5466	0	8	3
D-E	-38.6361	-33.6963	-160.559	-232.8914	91	8	5	7863	2	26	25
D-J	-6.6115	-45.4395	-167.973	-220.024	67	8	20	7563	1	26	24
D-K	-30.3022	-12.4276	-129.313	-172.0427	50	8	13	5013	0	6	3
E-F	-48.7719	-28.5244	-170.331	-247.6273	91	9	8	8246	2	30	26
E-I	-7.2055	-42.8134	-171.391	-221.4099	68	10	20	7717	2	26	24
E-J	-22.3511	-12.0838	-132.059	-166.4938	48	8	13	5031	0	6	3
F-H	-8.8684	-46.6778	-169.493	-225.0391	69	13	20	7809	2	26	27
F-I	-29.207	-12.5043	-142.73	-184.4412	49	9	13	5333	0	6	3
G-H	-11.3272	-12.9736	-146.192	-170.4928	87	7	6	7597	1	29	26
G-L	-20.8153	-37.3653	-174.699	-232.8796	92	13	5	8219	3	26	25
H-I	-10.8837	-30.8243	-153.089	-194.7969	89	4	5	7578	2	27	25
I-J	-20.7679	-30.5333	-180.52	-231.8212	90	10	8	8285	3	27	25
J-K	-7.6998	-25.863	-149.638	-183.2009	88	3	6	7563	2	27	25
K-L	-7.1618	-27.2955	-139.078	-173.5353	87	1	5	7248	2	27	24

Interface residues

• A-B: ALA127A, ALA137A, ALA30B, ALA37B, ALA53B, ALA57B, ALA59B, ALA5B, ALA81A, ALA85A, ALA99A, ALA99B, ARG140A, ARG38B, ARG41B, ARG79A, ARG89A, ARG95A, ARG95B, ASN133A, ASN171B, ASP122A, ASP123A, ASP58B, ASP91A, ASP91B, GLN173B, GLN24B, GLN29B, GLU117A, GLU120A, GLU64B, GLU83A, GLU87A, GLU98A, GLU98B, GLY114A, GLY116A, GLY124A, GLY129A, GLY132A, GLY23B, GLY28B, GLY54B, HIS35B, HIS4B, ILE102A, ILE119A, ILE125A, ILE128A, LEU101A, LEU110A, LEU111A, LEU126A, LEU136A, LEU62B, LEU84A, LEU94B, LEU97B, LYS34B, LYS39B, LYS78A, LYS86A, LYS92A, LYS92B, LYS96B, MET100A, MET33B, PHE27B, PHE3B, PHE52B, PHE60B, PHE63B, PRO121A, SER113A, SER1B, SER2B, SER55B, SER90A, THR115A, THR26B, THR36B, THR61B, THR6B, TRP88A, TRP88B, VAL112A, VAL118A, VAL25B, VAL31B, VAL32B, VAL56B, VAL82A, VAL93B
• A-F: ALA127F, ALA137F, ALA30A, ALA37A, ALA53A, ALA57A, ALA59A, ALA5A, ALA81F, ALA85F, ALA99A, ALA99F, ARG140F, ARG41A, ARG79F, ARG89F, ARG95A, ARG95F, ASN133F, ASP122F, ASP123F, ASP58A, ASP91A, ASP91F, GLN173A, GLN24A, GLN29A, GLU117F, GLU120F, GLU64A, GLU83F, GLU87F, GLU98A, GLU98F, GLY114F, GLY116F, GLY124F, GLY129F, GLY132F, GLY23A, GLY28A, GLY54A, HIS35A, HIS4A, ILE102F, ILE119F, ILE125F, ILE128F, LEU101F, LEU110F, LEU111F, LEU126F, LEU136F, LEU62A, LEU84F, LEU94A, LEU97A, LYS34A, LYS39A, LYS86F, LYS92A, LYS92F, LYS96A, MET100F, MET33A, PHE27A, PHE3A, PHE52A, PHE60A, PHE63A, PRO121F, SER113F, SER1A, SER2A, SER55A, SER90F, THR115F, THR26A, THR36A, THR61A, THR6A, TRP88A, TRP88F, VAL112F, VAL118F, VAL25A, VAL31A, VAL32A, VAL56A, VAL82F, VAL93A
• A-G: ALA127A, ALA127G, ALA135A, ALA135G, ALA137A, ALA137G, ALA138A, ALA138G, ALA141A, ALA141G, ALA146A, ALA146G, ALA158A, ALA158G, ALA159A, ALA159G, ALA163A, ALA163G, ARG140A, ARG140G, ARG157A, ARG157G, ASN133A, ASN133G, ASP122G, ASP123A, ASP123G, CYS167A, CYS167G, GLU148A, GLU148G, GLU154A, GLU154G, GLU161A, GLU161G, GLU165A, GLU165G, GLY132A, GLY132G, GLY139A, GLY139G, GLY147A, GLY147G, GLY164A, HIS145A, HIS145G, ILE125A, ILE125G, ILE155A, ILE155G, ILE166A, ILE166G, LEU136A, LEU136G, LEU142A, LEU142G, LYS143A, LYS143G, LYS144A, LYS144G, MET150A, MET150G, SER149A, SER149G, THR162A, THR162G, TYR134A, TYR134G
• A-H: ALA163A, ALA163H, ALA30A, ALA30H, ASN171A, CYS167A, CYS167H, GLN24A, GLN24H, GLN29A, GLN29H, GLU165A, GLU165H, GLY131A, GLY131H, GLY164A, GLY164H, GLY28A, GLY28H, HIS35A, HIS35H, HIS4A, HIS4H, ILE166A, ILE166H, LYS34A, LYS34H, MET33A, MET33H, PHE27A, PHE27H, SER130A, SER130H, THR170A, THR170H, THR26A, THR26H, TYR134A, TYR134H, TYR169A, TYR169H, VAL168A, VAL168H, VAL25A, VAL25H, VAL31A, VAL31H, VAL32A, VAL32H
• B-C: ALA127B, ALA137B, ALA30C, ALA37C, ALA53C, ALA57C, ALA59C, ALA5C, ALA81B, ALA85B, ALA99B, ALA99C, ARG140B, ARG79B, ARG89B, ARG95B, ARG95C, ASN133B, ASP122B, ASP123B, ASP58C, ASP91B, ASP91C, GLN173C, GLN24C, GLU117B, GLU120B, GLU64C, GLU83B, GLU87B, GLU98B, GLU98C, GLY114B, GLY116B, GLY124B, GLY129B, GLY132B, GLY23C, GLY28C, GLY54C, HIS35C, HIS4C, ILE102B, ILE119B, ILE125B, ILE128B, LEU101B, LEU110B, LEU111B, LEU126B, LEU136B, LEU62C, LEU84B, LEU94C, LEU97C, LYS34C, LYS39C, LYS78B, LYS86B, LYS92B, LYS92C, LYS96C, MET100B, MET33C, PHE27C, PHE3C, PHE52C, PHE60C, PRO121B, SER113B, SER1C, SER2C, SER55C, SER90B, THR115B, THR26C, THR36C, THR61C, THR6C, TRP88B, TRP88C, VAL112B, VAL118B, VAL25C, VAL31C, VAL32C, VAL56C, VAL82B, VAL93C
• B-G: ALA163G, ALA30B, ALA30G, ASN171B, ASN171G, CYS167B, CYS167G, GLN24B, GLN24G, GLN29B, GLN29G, GLU165B, GLU165G, GLY131B, GLY131G, GLY164B, GLY164G, GLY28B, GLY28G, HIS35B, HIS35G, HIS4B, HIS4G, ILE166B, ILE166G, MET33B, MET33G, PHE27B, PHE27G, SER130B, SER130G, THR170B, THR170G, THR26B, THR26G, TYR134B, TYR134G, TYR169B, TYR169G, VAL168B, VAL168G, VAL25B, VAL25G, VAL31B, VAL31G, VAL32B, VAL32G
• B-L: ALA127B, ALA135B, ALA135L, ALA137B, ALA137L, ALA138B, ALA138L, ALA141B, ALA141L, ALA146B, ALA146L, ALA158B, ALA158L, ALA159B, ALA159L, ALA163B, ALA163L, ARG140B, ARG140L, ARG157B, ARG157L, ASN133B, ASN133L, ASP123B, ASP123L, CYS167B, CYS167L, GLU148L, GLU154B, GLU154L, GLU161B, GLU161L, GLU165B, GLU165L, GLY132B, GLY132L, GLY139B, GLY139L, HIS145B, HIS145L, ILE125B, ILE125L, ILE155B, ILE155L, ILE166B, ILE166L, LEU136B, LEU136L, LEU142B, LEU142L, LYS143B, LYS143L, LYS144B, LYS144L, MET150B, MET150L, SER149B, SER149L, THR162B, THR162L, TYR134B, TYR134L
• C-D: ALA127C, ALA137C, ALA30D, ALA37D, ALA53D, ALA57D, ALA59D, ALA5D, ALA81C, ALA85C, ALA99C, ALA99D, ARG140C, ARG41D, ARG79C, ARG89C, ARG95C, ARG95D, ASN133C, ASP122C, ASP123C, ASP58D, ASP91C, ASP91D, GLN173D, GLN29D, GLU117C, GLU120C, GLU64D, GLU83C, GLU87C, GLU98C, GLU98D, GLY114C, GLY116C, GLY124C, GLY129C, GLY132C, GLY23D, GLY28D, GLY54D, HIS35D, HIS4D, ILE102C, ILE119C, ILE125C, ILE128C, LEU101C, LEU110C, LEU111C, LEU126C, LEU136C, LEU62D, LEU84C, LEU94D, LEU97D, LYS34D, LYS39D, LYS86C, LYS92C, LYS92D, LYS96D, MET100C, MET33D, PHE27D, PHE3D, PHE52D, PHE60D, PRO121C, SER113C, SER1D, SER2D, SER55D, SER90C, THR115C, THR26D, THR36D, THR61D, THR6D, TRP88C, TRP88D, VAL112C, VAL118C, VAL25D, VAL31D, VAL32D, VAL56D, VAL82C, VAL93D
• C-K: ALA127C, ALA127K, ALA135C, ALA135K, ALA137C, ALA137K, ALA138C, ALA138K, ALA141C, ALA141K, ALA146C, ALA146K, ALA158C, ALA158K, ALA159C, ALA159K, ALA163C, ALA163K, ARG140C, ARG140K, ARG157C, ARG157K, ASN133C, ASN133K, ASP122C, ASP122K, ASP123C, ASP123K, CYS167C, CYS167K, GLU148C, GLU148K, GLU154C, GLU154K, GLU161C, GLU161K, GLU165C, GLU165K, GLY132C, GLY132K, GLY139C, GLY139K, GLY147C, GLY147K, HIS145C, HIS145K, ILE125C, ILE125K, ILE155C, ILE155K, ILE166C, ILE166K, LEU136C, LEU136K, LEU142C, LEU142K, LYS143C, LYS143K, LYS144C, LYS144K, MET150C, MET150K, SER149C, SER149K, THR162C, THR162K, TYR134C, TYR134K
• C-L: ALA163C, ALA163L, ALA30C, ALA30L, ASN171C, ASN171L, CYS167C, CYS167L, GLN24C, GLN24L, GLN29C, GLN29L, GLU165C, GLU165L, GLY131C, GLY131L, GLY164C, GLY164L, GLY28C, GLY28L, HIS35C, HIS35L, HIS4C, HIS4L, ILE166C, ILE166L, LYS34C, LYS34L, MET33C, MET33L, PHE27C, PHE27L, SER130C, SER130L, THR170C, THR170L, THR26C, THR26L, TYR134C, TYR134L, TYR169C, TYR169L, VAL168C, VAL168L, VAL25C, VAL25L, VAL31C, VAL31L, VAL32C, VAL32L
• D-E: ALA127D, ALA137D, ALA30E, ALA37E, ALA53E, ALA57E, ALA59E, ALA5E, ALA81D, ALA85D, ALA99D, ALA99E, ARG140D, ARG41E, ARG79D, ARG89D, ARG95D, ARG95E, ASN133D, ASP122D, ASP123D, ASP58E, ASP91D, ASP91E, GLN173E, GLN24E, GLN29E, GLU117D, GLU120D, GLU64E, GLU83D, GLU87D, GLU98D, GLU98E, GLY114D, GLY116D, GLY124D, GLY129D, GLY132D, GLY23E, GLY28E, GLY54E, HIS35E, HIS4E, ILE102D, ILE119D, ILE125D, ILE128D, LEU101D, LEU110D, LEU111D, LEU126D, LEU136D, LEU62E, LEU84D, LEU94E, LEU97E, LYS34E, LYS39E, LYS86D, LYS92D, LYS92E, LYS96E, MET100D, MET33E, PHE27E, PHE3E, PHE52E, PHE60E, PRO121D, SER113D, SER1E, SER2E, SER55E, SER90D, THR115D, THR26E, THR36E, THR61E, THR6E, TRP88D, TRP88E, TYR134D, VAL112D, VAL118D, VAL25E, VAL31E, VAL32E, VAL56E, VAL82D, VAL93E
• D-J: ALA127D, ALA127J, ALA135D, ALA135J, ALA137D, ALA137J, ALA138D, ALA138J, ALA141D, ALA141J, ALA146D, ALA146J, ALA158D, ALA158J, ALA159D, ALA159J, ALA163D, ALA163J, ARG140D, ARG140J, ARG157D, ARG157J, ASN133D, ASN133J, ASP122J, ASP123D, ASP123J, CYS167D, CYS167J, GLU148D, GLU148J, GLU154D, GLU154J, GLU161D, GLU161J, GLU165D, GLU165J, GLY132D, GLY132J, GLY139D, GLY139J, GLY147D, GLY147J, HIS145D, HIS145J, ILE125D, ILE125J, ILE155D, ILE155J, ILE166D, ILE166J, LEU136D, LEU136J, LEU142D, LEU142J, LYS143D, LYS143J, LYS144D, LYS144J, MET150D, MET150J, SER149D, SER149J, THR162D, THR162J, TYR134D, TYR134J
• D-K: ALA163D, ALA163K, ALA30D, ALA30K, ASN171D, ASN171K, CYS167D, CYS167K, GLN24D, GLN24K, GLN29D, GLN29K, GLU165D, GLU165K, GLY131D, GLY131K, GLY164D, GLY164K, GLY28D, GLY28K, HIS35D, HIS35K, HIS4D, HIS4K, ILE166D, ILE166K, LYS34D, LYS34K, MET33D, MET33K, PHE27D, PHE27K, SER130D, SER130K, THR170D, THR170K, THR26D, THR26K, TYR134D, TYR134K, TYR169D, TYR169K, VAL168D, VAL168K, VAL25D, VAL25K, VAL31D, VAL31K, VAL32D, VAL32K
• E-F: ALA127E, ALA137E, ALA30F, ALA37F, ALA53F, ALA57F, ALA59F, ALA5F, ALA81E, ALA85E, ALA99E, ALA99F, ARG140E, ARG41F, ARG79E, ARG89E, ARG95E, ARG95F, ASN133E, ASP122E, ASP123E, ASP58F, ASP91E, ASP91F, GLN173F, GLN24F, GLN29F, GLU117E, GLU120E, GLU64F, GLU83E, GLU87E, GLU98E, GLU98F, GLY114E, GLY116E, GLY124E, GLY129E, GLY132E, GLY23F, GLY28F, GLY54F, HIS35F, HIS4F, ILE102E, ILE119E, ILE125E, ILE128E, LEU101E, LEU110E, LEU111E, LEU126E, LEU136E, LEU62F, LEU84E, LEU94F, LEU97F, LYS34F, LYS39F, LYS86E, LYS92E, LYS92F, LYS96F, MET100E, MET33F, PHE27F, PHE3F, PHE52F, PHE60F, PHE63F, PRO121E, SER113E, SER1F, SER2F, SER55F, SER90E, THR115E, THR26F, THR36F, THR61F, THR6F, TRP88E, TRP88F, VAL112E, VAL118E, VAL25F, VAL31F, VAL32F, VAL56F, VAL82E, VAL93F
• E-I: ALA127E, ALA127I, ALA135E, ALA135I, ALA137E, ALA137I, ALA138E, ALA138I, ALA141E, ALA141I, ALA146E, ALA146I, ALA158E, ALA158I, ALA159E, ALA159I, ALA163E, ALA163I, ARG140E, ARG140I, ARG157E, ARG157I, ASN133E, ASN133I, ASP122E, ASP122I, ASP123E, ASP123I, CYS167E, CYS167I, GLU148E, GLU148I, GLU154E, GLU154I, GLU161E, GLU161I, GLU165E, GLU165I, GLY132E, GLY132I, GLY139E, GLY139I, GLY164E, HIS145E, HIS145I, ILE125E, ILE125I, ILE155E, ILE155I, ILE166E, ILE166I, LEU136E, LEU136I, LEU142E, LEU142I, LYS143E, LYS143I, LYS144E, LYS144I, MET150E, MET150I, PHE9I, SER149E, SER149I, THR162E, THR162I, TYR134E, TYR134I
• E-J: ALA163E, ALA163J, ALA30E, ALA30J, ASN171E, ASN171J, CYS167E, CYS167J, GLN24E, GLN24J, GLN29E, GLN29J, GLU165E, GLU165J, GLY131E, GLY131J, GLY164E, GLY164J, GLY28E, GLY28J, HIS35E, HIS35J, HIS4E, HIS4J, ILE166E, ILE166J, MET33E, MET33J, PHE27E, PHE27J, SER130E, SER130J, THR170E, THR170J, THR26E, THR26J, TYR134E, TYR134J, TYR169E, TYR169J, VAL168E, VAL168J, VAL25E, VAL25J, VAL31E, VAL31J, VAL32E, VAL32J
• F-H: ALA127F, ALA127H, ALA135F, ALA135H, ALA137F, ALA137H, ALA138F, ALA138H, ALA141F, ALA141H, ALA146F, ALA146H, ALA158F, ALA158H, ALA159F, ALA159H, ALA163F, ALA163H, ARG140F, ARG140H, ARG157F, ARG157H, ASN133F, ASN133H, ASP122F, ASP122H, ASP123F, ASP123H, CYS167F, CYS167H, GLU148F, GLU148H, GLU154F, GLU154H, GLU161F, GLU161H, GLU165F, GLU165H, GLY131F, GLY132F, GLY132H, GLY139F, GLY139H, GLY147F, GLY147H, HIS145F, HIS145H, ILE125F, ILE125H, ILE155F, ILE155H, ILE166F, ILE166H, LEU136F, LEU136H, LEU142F, LEU142H, LYS143F, LYS143H, LYS144F, LYS144H, MET150F, MET150H, SER149F, SER149H, THR162F, THR162H, TYR134F, TYR134H
• F-I: ALA163F, ALA163I, ALA30F, ALA30I, ASN171F, ASN171I, CYS167F, CYS167I, GLN24F, GLN24I, GLN29F, GLN29I, GLU165F, GLU165I, GLY131F, GLY131I, GLY164F, GLY164I, GLY28F, GLY28I, HIS35F, HIS35I, HIS4F, HIS4I, ILE166F, ILE166I, LYS34F, MET33F, MET33I, PHE27F, PHE27I, SER130F, SER130I, THR170F, THR170I, THR26F, THR26I, TYR134F, TYR134I, TYR169F, TYR169I, VAL168F, VAL168I, VAL25F, VAL25I, VAL31F, VAL31I, VAL32F, VAL32I
• G-H: ALA127G, ALA30H, ALA37H, ALA57H, ALA59H, ALA5H, ALA81G, ALA85G, ALA99G, ALA99H, ARG140G, ARG79G, ARG89G, ARG95G, ARG95H, ASN133G, ASP122G, ASP123G, ASP58H, ASP91G, GLN173H, GLN24H, GLN29H, GLU117G, GLU120G, GLU64H, GLU83G, GLU87G, GLU98G, GLU98H, GLY114G, GLY116G, GLY124G, GLY129G, GLY132G, GLY23H, GLY28H, GLY54H, HIS35H, HIS4H, ILE102G, ILE119G, ILE125G, ILE128G, LEU101G, LEU110G, LEU111G, LEU126G, LEU136G, LEU62H, LEU84G, LEU94H, LEU97H, LYS34H, LYS39H, LYS78G, LYS86G, LYS92G, LYS92H, LYS96H, MET100G, MET33H, PHE27H, PHE3H, PHE52H, PHE60H, PRO121G, SER113G, SER1H, SER2H, SER55H, SER90G, THR115G, THR26H, THR36H, THR61H, THR6H, TRP88G, TRP88H, VAL112G, VAL118G, VAL25H, VAL31H, VAL32H, VAL56H, VAL82G, VAL93H
• G-L: ALA127L, ALA137L, ALA30G, ALA37G, ALA53G, ALA57G, ALA59G, ALA5G, ALA81L, ALA85L, ALA99G, ALA99L, ARG140L, ARG41G, ARG79L, ARG89L, ARG95G, ARG95L, ASN133L, ASP122L, ASP123L, ASP58G, ASP91G, ASP91L, GLN173G, GLN24G, GLN29G, GLU117L, GLU120L, GLU64G, GLU83L, GLU87L, GLU98G, GLU98L, GLY114L, GLY116L, GLY124L, GLY129L, GLY132L, GLY23G, GLY28G, GLY54G, HIS35G, HIS4G, ILE102L, ILE119L, ILE125L, ILE128L, LEU101L, LEU110L, LEU111L, LEU126L, LEU136L, LEU62G, LEU84L, LEU94G, LEU97G, LYS34G, LYS39G, LYS78L, LYS86L, LYS92G, LYS92L, LYS96G, MET100L, MET33G, PHE27G, PHE3G, PHE52G, PHE60G, PRO121L, SER113L, SER1G, SER2G, SER55G, SER90L, THR115L, THR26G, THR36G, THR61G, THR6G, TRP88G, TRP88L, TYR134L, VAL112L, VAL118L, VAL25G, VAL31G, VAL32G, VAL56G, VAL82L, VAL93G
• H-I: ALA127H, ALA137H, ALA30I, ALA37I, ALA57I, ALA59I, ALA5I, ALA81H, ALA85H, ALA99H, ALA99I, ARG140H, ARG41I, ARG79H, ARG89H, ARG95H, ARG95I, ASN133H, ASP122H, ASP123H, ASP58I, ASP91H, ASP91I, GLN173I, GLN24I, GLN29I, GLU117H, GLU120H, GLU64I, GLU83H, GLU87H, GLU98H, GLU98I, GLY114H, GLY116H, GLY124H, GLY129H, GLY132H, GLY23I, GLY28I, GLY54I, HIS35I, HIS4I, ILE102H, ILE119H, ILE125H, ILE128H, LEU101H, LEU110H, LEU111H, LEU126H, LEU136H, LEU62I, LEU84H, LEU94I, LEU97I, LYS34I, LYS39I, LYS86H, LYS92H, LYS92I, LYS96I, MET100H, MET33I, PHE27I, PHE3I, PHE52I, PHE60I, PRO121H, SER113H, SER1I, SER2I, SER55I, SER90H, THR115H, THR26I, THR36I, THR61I, THR6I, TRP88H, TRP88I, VAL112H, VAL118H, VAL25I, VAL31I, VAL32I, VAL56I, VAL82H, VAL93I
• I-J: ALA127I, ALA137I, ALA30J, ALA37J, ALA57J, ALA59J, ALA5J, ALA81I, ALA85I, ALA99I, ALA99J, ARG140I, ARG41J, ARG79I, ARG89I, ARG95I, ARG95J, ASN133I, ASN171J, ASP122I, ASP123I, ASP58J, ASP91I, GLN173J, GLN24J, GLN29J, GLU117I, GLU120I, GLU64J, GLU83I, GLU87I, GLU98I, GLU98J, GLY114I, GLY116I, GLY124I, GLY129I, GLY132I, GLY23J, GLY28J, GLY54J, HIS35J, HIS4J, ILE102I, ILE119I, ILE125I, ILE128I, LEU101I, LEU110I, LEU111I, LEU126I, LEU136I, LEU62J, LEU84I, LEU94J, LEU97J, LYS34J, LYS39J, LYS78I, LYS86I, LYS92I, LYS92J, LYS96J, MET100I, MET33J, PHE27J, PHE3J, PHE52J, PHE60J, PRO121I, SER113I, SER1J, SER2J, SER55J, SER90I, THR115I, THR26J, THR36J, THR61J, THR6J, TRP88I, TRP88J, VAL112I, VAL118I, VAL25J, VAL31J, VAL32J, VAL56J, VAL82I, VAL93J
• J-K: ALA127J, ALA137J, ALA30K, ALA37K, ALA57K, ALA59K, ALA5K, ALA81J, ALA85J, ALA99J, ALA99K, ARG140J, ARG41K, ARG79J, ARG89J, ARG95J, ARG95K, ASN133J, ASP122J, ASP123J, ASP58K, ASP91J, GLN173K, GLN24K, GLN29K, GLU117J, GLU120J, GLU64K, GLU83J, GLU87J, GLU98J, GLU98K, GLY114J, GLY116J, GLY124J, GLY129J, GLY132J, GLY23K, GLY28K, GLY54K, HIS35K, HIS4K, ILE102J, ILE119J, ILE125J, ILE128J, LEU101J, LEU110J, LEU111J, LEU126J, LEU136J, LEU62K, LEU84J, LEU94K, LEU97K, LYS34K, LYS39K, LYS86J, LYS92J, LYS92K, LYS96K, MET100J, MET33K, PHE27K, PHE3K, PHE52K, PHE60K, PRO121J, SER113J, SER1K, SER2K, SER55K, SER90J, THR115J, THR26K, THR36K, THR61K, THR6K, TRP88J, TRP88K, VAL112J, VAL118J, VAL25K, VAL31K, VAL32K, VAL56K, VAL82J, VAL93K
• K-L: ALA127K, ALA137K, ALA30L, ALA37L, ALA57L, ALA59L, ALA5L, ALA81K, ALA85K, ALA99K, ALA99L, ARG140K, ARG79K, ARG89K, ARG95K, ARG95L, ASN133K, ASP122K, ASP123K, ASP58L, ASP91K, ASP91L, GLN173L, GLN29L, GLU117K, GLU120K, GLU64L, GLU83K, GLU87K, GLU98K, GLU98L, GLY114K, GLY116K, GLY124K, GLY129K, GLY132K, GLY23L, GLY28L, GLY54L, HIS35L, HIS4L, ILE102K, ILE119K, ILE125K, ILE128K, LEU101K, LEU110K, LEU111K, LEU126K, LEU136K, LEU62L, LEU84K, LEU94L, LEU97L, LYS34L, LYS39L, LYS86K, LYS92K, LYS92L, LYS96L, MET100K, MET33L, PHE27L, PHE3L, PHE52L, PHE60L, PRO121K, SER113K, SER1L, SER2L, SER55L, SER90K, THR115K, THR26L, THR36L, THR61L, THR6L, TRP88K, TRP88L, VAL112K, VAL118K, VAL25L, VAL31L, VAL32L, VAL56L, VAL82K, VAL93L