2YZD

crystal structure of uricase from arthrobacter globiformis in complex with 8-azaxanthin (inhibitor)

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 214
  • Norm. En. per Res.: -5.448
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-241.7066	-152.6078	-744.351	-1138.6654	216	33	28	29993	13	85	86
A-C	-37.2295	-45.8323	-78.4139	-161.4757	40	4	2	2769	4	8	9
A-D	-261.3437	-33.6081	-922.164	-1217.1158	263	38	30	36213	2	73	68
A-E	0.0	0.0	-30.2509	-30.2509	13	1	0	980	0	0	2
A-F	0.0	0.0	-0.0109	-0.0109	5	0	0	8	0	1	5
A-G	-22.5468	25.2231	-130.192	-127.5157	64	2	0	4985	0	25	21
A-H	0.0	0.0	-0.0023	-0.0023	4	0	0	4	0	2	3
B-C	-265.1683	-31.5357	-907.009	-1203.713	264	41	30	36027	2	71	71
B-D	-28.8617	-45.3084	-81.2005	-155.3706	41	2	2	3080	4	8	9
B-G	0.0	0.0	-0.0021	-0.0021	4	0	0	3	0	2	3
C-D	-235.8627	-159.127	-741.757	-1136.7466	216	34	29	29824	16	87	86
C-E	0.0	0.0	-0.1232	-0.1232	13	0	0	65	0	4	2
C-G	0.0	0.0	-28.1808	-28.1808	13	0	0	937	0	0	2
D-G	0.0	0.0	-0.0154	-0.0154	4	0	0	12	0	1	4
E-F	-252.2878	-156.9227	-756.666	-1165.8765	214	40	30	30589	14	87	88
E-G	-21.2772	-45.6264	-82.2715	-149.1751	41	2	2	2842	4	8	9
E-H	-240.9044	-23.3307	-910.667	-1174.9021	263	39	30	36050	2	75	70
F-G	-243.8682	-26.2526	-913.204	-1183.3248	264	32	30	35974	2	76	71
F-H	-33.2987	-44.9555	-84.6291	-162.8833	42	5	2	3201	4	10	9
G-H	-249.8647	-119.0446	-745.481	-1114.3903	214	34	30	30247	14	86	86

Interface residues

• A-B: ALA124A, ALA124B, ALA183A, ALA183B, ALA213A, ALA213B, ALA215A, ALA215B, ALA271A, ALA271B, ALA272A, ALA272B, ALA35A, ALA35B, ALA76A, ALA76B, ALA78A, ALA78B, ARG117A, ARG117B, ARG127A, ARG127B, ARG180A, ARG180B, ARG207A, ARG207B, ARG26A, ARG26B, ARG32A, ARG32B, ARG36A, ARG79A, ARG79B, ARG91A, ARG91B, ASN119A, ASN119B, ASN128A, ASN128B, ASN264A, ASN264B, ASN266A, ASN266B, ASN33A, ASN33B, ASN43A, ASN43B, ASN72A, ASN72B, ASP116A, ASP116B, ASP122A, ASP122B, ASP179A, ASP179B, ASP185A, ASP185B, ASP256A, ASP256B, ASP263A, ASP263B, ASP273A, ASP273B, ASP41A, ASP41B, ASP68A, ASP68B, ASP80A, ASP80B, GLN262A, GLN262B, GLN40A, GLN40B, GLU131A, GLU131B, GLU151A, GLU151B, GLU216A, GLU216B, GLU24A, GLU24B, GLU267A, GLU267B, GLU38A, GLU38B, GLY152A, GLY152B, GLY160A, GLY160B, GLY208A, GLY208B, GLY261A, GLY261B, GLY81A, GLY81B, HIS121A, HIS121B, HIS123A, HIS123B, HIS218A, HIS218B, HIS251A, HIS251B, HIS252A, HIS252B, HIS37A, HIS37B, ILE118A, ILE118B, ILE181A, ILE181B, ILE39A, ILE39B, LEU153A, LEU153B, LEU156A, LEU156B, LEU182A, LEU182B, LEU210A, LEU210B, LEU211A, LEU211B, LEU254A, LEU254B, LEU257A, LEU257B, LEU27A, LEU27B, LEU42A, LEU42B, LYS129A, LYS129B, LYS157A, LYS157B, LYS212A, LYS212B, LYS250A, LYS250B, LYS29A, LYS29B, LYS71A, LYS71B, MET229A, PHE113A, PHE113B, PHE114A, PHE114B, PHE125A, PHE125B, PHE214A, PHE214B, PHE253A, PHE253B, PHE260A, PHE260B, PHE269A, PHE269B, PHE77A, PHE77B, PHE82A, PHE82B, PHE88A, PHE88B, PRO259A, PRO259B, PRO265A, PRO265B, SER126A, SER126B, SER130A, SER130B, SER158A, SER158B, SER161A, SER161B, SER219A, SER219B, THR154A, THR154B, THR159A, THR159B, THR184A, THR184B, THR217A, THR217B, THR31A, THR31B, THR69A, THR69B, THR73A, THR73B, TRP115A, TRP115B, TYR270A, TYR270B, TYR75A, TYR75B, VAL132A, VAL132B, VAL155A, VAL155B, VAL186A, VAL186B, VAL255A, VAL255B, VAL25A, VAL25B, VAL268A, VAL268B, VAL28A, VAL28B, VAL30A, VAL30B, VAL74A, VAL74B
• A-C: ALA271A, ALA271C, ALA272A, ALA272C, ARG274A, ARG274C, ASP169A, ASP169C, ASP256A, ASP256C, ASP273A, ASP273C, GLN262A, GLN262C, GLY261A, GLY261C, LEU174A, LEU174C, LEU257A, LEU257C, LYS170A, LYS170C, PHE253A, PHE253C, PHE260A, PHE260C, PRO259A, PRO259C, PRO275A, PRO275C, THR172A, THR172C, THR173A, THR173C, TYR171A, TYR171C, TYR270A, TYR270C, TYR276A, TYR276C
• A-D: ALA221A, ALA221D, ALA232A, ALA232D, ALA23A, ALA23D, ALA281A, ALA281D, ALA290A, ALA290D, ALA54A, ALA54D, ALA55A, ALA55D, ALA58A, ALA58D, ALA62A, ALA62D, ALA66A, ALA66D, ALA76A, ALA76D, ARG107A, ARG107D, ARG168A, ARG168D, ARG180A, ARG180D, ARG231A, ARG231D, ARG26A, ARG26D, ARG274A, ARG274D, ARG285A, ARG285D, ARG49A, ARG49D, ARG79A, ARG79D, ARG91A, ARG91D, ASN18A, ASN18D, ASN249A, ASN249D, ASN297A, ASN297D, ASN43A, ASN43D, ASN61A, ASN61D, ASN72A, ASN72D, ASP169A, ASP169D, ASP241A, ASP241D, ASP273A, ASP273D, ASP291A, ASP291D, ASP60A, ASP60D, ASP68A, ASP68D, ASP80A, ASP80D, GLN111A, GLN111D, GLN175A, GLN175D, GLN17A, GLN17D, GLN19A, GLN19D, GLN223A, GLN223D, GLN224A, GLN224D, GLN284A, GLN284D, GLN47A, GLN47D, GLN70A, GLN70D, GLU162A, GLU162D, GLU176A, GLU176D, GLU228A, GLU228D, GLU235A, GLU235D, GLU242A, GLU242D, GLU24A, GLU24D, GLU280A, GLU280D, GLU286A, GLU286D, GLU53A, GLU53D, GLY165A, GLY165D, GLY16A, GLY16D, GLY21A, GLY21D, GLY230A, GLY230D, GLY277A, GLY277D, GLY287A, GLY287D, GLY59A, GLY59D, GLY99A, GLY99D, HIS164A, HIS164D, HIS218A, HIS218D, HIS251A, HIS251D, HIS292A, HIS292D, HIS56A, HIS56D, HIS63A, HIS63D, HIS95A, HIS95D, ILE234A, ILE234D, ILE240D, ILE243A, ILE243D, ILE279A, ILE279D, ILE283A, ILE283D, LEU15A, LEU15D, LEU174A, LEU174D, LEU220A, LEU220D, LEU222A, LEU222D, LEU247A, LEU247D, LEU278A, LEU278D, LEU42A, LEU42D, LEU48A, LEU48D, LYS12A, LYS12D, LYS170A, LYS170D, LYS22A, LYS22D, LYS244A, LYS244D, LYS71A, LYS71D, MET226A, MET226D, MET245A, MET245D, PHE100A, PHE100D, PHE113A, PHE113D, PHE163A, PHE163D, PHE166A, PHE166D, PHE253A, PHE253D, PHE52A, PHE52D, PHE77A, PHE77D, PHE96A, PHE96D, PRO167A, PRO167D, PRO238A, PRO238D, PRO248A, PRO248D, PRO275A, PRO275D, PRO293A, PRO293D, SER219A, SER219D, SER246A, SER246D, SER288A, SER288D, SER296A, SER296D, SER46A, SER46D, THR11A, THR11D, THR172A, THR172D, THR173A, THR173D, THR225A, THR225D, THR236A, THR236D, THR282A, THR282D, THR45A, THR45D, THR57A, THR57D, THR67A, THR67D, THR69A, THR69D, THR73A, THR73D, TRP102A, TRP102D, TRP295A, TRP295D, TYR171A, TYR171D, TYR20A, TYR20D, TYR227A, TYR227D, TYR276A, TYR276D, TYR75A, TYR75D, VAL103A, VAL103D, VAL13A, VAL13D, VAL14A, VAL14D, VAL233A, VAL233D, VAL25A, VAL25D, VAL44A, VAL44D, VAL64A, VAL64D, VAL65A, VAL65D, VAL74A, VAL74D
• A-E: ASP256A, GLN258A, GLN258E, GLN262A, GLN262E, GLY261A, GLY261E, LEU257A, LEU257E, PHE260A, PHE260E, PRO259A, PRO259E
• A-F: ASN72F, ASP263A, GLN258A, PHE100F, THR69F
• A-G: ARG168A, ARG168G, ARG180A, ARG180G, ASN264A, ASN264G, ASN266A, ASN266G, ASP169A, ASP169G, ASP179A, ASP179G, ASP256A, ASP256G, ASP263A, ASP263G, GLN175A, GLN175G, GLN258A, GLN258G, GLN262A, GLN262G, GLU162A, GLU162G, GLU176A, GLU176G, GLY165A, GLY165G, GLY261A, GLY261G, HIS164A, HIS164G, LEU174A, LEU174G, LEU220A, LEU220G, LEU254A, LEU254G, LEU257A, LEU257G, LYS170A, LYS170G, PHE163A, PHE163G, PHE166A, PHE166G, PHE260A, PHE260G, PRO167A, PRO167G, PRO259A, PRO259G, PRO265A, PRO265G, THR172A, THR172G, THR173A, THR173G, THR177A, THR177G, THR178A, THR178G, TYR171A, TYR171G
• A-H: ARG168A, ARG79H, ASP169A, LYS170A
• B-C: ALA221B, ALA221C, ALA232B, ALA232C, ALA23B, ALA23C, ALA281B, ALA281C, ALA290B, ALA290C, ALA54B, ALA54C, ALA55B, ALA55C, ALA58B, ALA58C, ALA62B, ALA62C, ALA66B, ALA66C, ALA76B, ALA76C, ARG107B, ARG107C, ARG127C, ARG168B, ARG168C, ARG180B, ARG180C, ARG231B, ARG231C, ARG26B, ARG26C, ARG274B, ARG274C, ARG285B, ARG285C, ARG49B, ARG49C, ARG79B, ARG79C, ARG91B, ARG91C, ASN18B, ASN18C, ASN249B, ASN249C, ASN297B, ASN297C, ASN43B, ASN43C, ASN61B, ASN61C, ASN72B, ASN72C, ASP169B, ASP169C, ASP241B, ASP241C, ASP273B, ASP273C, ASP291B, ASP291C, ASP60B, ASP60C, ASP68B, ASP68C, ASP80B, ASP80C, GLN111B, GLN111C, GLN175B, GLN175C, GLN17B, GLN17C, GLN19B, GLN19C, GLN223B, GLN223C, GLN224B, GLN224C, GLN284B, GLN284C, GLN47B, GLN47C, GLN70B, GLN70C, GLU162B, GLU162C, GLU176B, GLU176C, GLU228B, GLU228C, GLU235B, GLU235C, GLU242B, GLU242C, GLU24B, GLU24C, GLU280B, GLU280C, GLU286B, GLU286C, GLU53B, GLU53C, GLY165B, GLY165C, GLY16B, GLY16C, GLY21B, GLY21C, GLY230B, GLY230C, GLY277B, GLY277C, GLY287B, GLY287C, GLY59B, GLY59C, GLY99B, GLY99C, HIS164B, HIS164C, HIS218B, HIS218C, HIS237C, HIS251B, HIS251C, HIS292B, HIS292C, HIS56B, HIS56C, HIS63B, HIS63C, HIS95B, HIS95C, ILE234B, ILE234C, ILE243B, ILE243C, ILE279B, ILE279C, ILE283B, ILE283C, LEU15B, LEU15C, LEU174B, LEU174C, LEU220B, LEU220C, LEU222B, LEU222C, LEU247B, LEU247C, LEU278B, LEU278C, LEU42B, LEU42C, LEU48B, LEU48C, LYS12B, LYS12C, LYS170B, LYS170C, LYS22B, LYS22C, LYS244B, LYS244C, LYS71B, LYS71C, MET226B, MET226C, MET245B, MET245C, PHE100B, PHE100C, PHE113B, PHE113C, PHE163B, PHE163C, PHE166B, PHE166C, PHE253B, PHE253C, PHE52B, PHE52C, PHE77B, PHE77C, PHE96B, PHE96C, PRO167B, PRO167C, PRO238B, PRO238C, PRO248B, PRO248C, PRO275B, PRO275C, PRO293B, SER219B, SER219C, SER246B, SER246C, SER288B, SER288C, SER296B, SER296C, SER46B, SER46C, THR11B, THR11C, THR172B, THR172C, THR173B, THR173C, THR177C, THR225B, THR225C, THR236B, THR236C, THR282B, THR282C, THR45B, THR45C, THR57B, THR57C, THR67B, THR67C, THR69B, THR69C, THR73B, THR73C, TRP102B, TRP102C, TRP295B, TRP295C, TYR171B, TYR171C, TYR20B, TYR20C, TYR227B, TYR227C, TYR276B, TYR276C, TYR75B, TYR75C, VAL103B, VAL103C, VAL13B, VAL13C, VAL14B, VAL14C, VAL233B, VAL233C, VAL25B, VAL25C, VAL44B, VAL44C, VAL64B, VAL64C, VAL65B, VAL65C, VAL74B, VAL74C
• B-D: ALA271B, ALA271D, ALA272B, ALA272D, ARG274B, ARG274D, ASP169B, ASP169D, ASP256B, ASP256D, ASP273B, ASP273D, GLN262B, GLN262D, GLY261B, GLY261D, LEU174B, LEU174D, LEU257B, LEU257D, LYS170B, LYS170D, LYS250D, PHE253B, PHE253D, PHE260B, PHE260D, PRO259B, PRO259D, PRO275B, PRO275D, THR172B, THR172D, THR173B, THR173D, TYR171B, TYR171D, TYR270B, TYR270D, TYR276B, TYR276D
• B-G: ARG168G, ARG79B, ASP169G, LYS170G
• C-D: ALA124C, ALA124D, ALA183C, ALA183D, ALA213C, ALA213D, ALA215C, ALA215D, ALA271C, ALA271D, ALA272C, ALA272D, ALA35C, ALA35D, ALA76C, ALA76D, ALA78C, ALA78D, ARG117C, ARG117D, ARG127C, ARG127D, ARG180C, ARG180D, ARG207C, ARG207D, ARG26C, ARG26D, ARG32C, ARG32D, ARG36C, ARG36D, ARG79C, ARG79D, ARG91C, ARG91D, ASN119C, ASN119D, ASN128C, ASN128D, ASN264C, ASN264D, ASN266C, ASN266D, ASN33C, ASN33D, ASN43C, ASN43D, ASN72C, ASN72D, ASP116C, ASP116D, ASP122C, ASP122D, ASP179C, ASP179D, ASP185C, ASP185D, ASP256C, ASP256D, ASP263C, ASP263D, ASP273C, ASP273D, ASP41C, ASP41D, ASP68C, ASP68D, ASP80C, ASP80D, GLN262C, GLN262D, GLN40C, GLN40D, GLU131C, GLU131D, GLU151C, GLU151D, GLU216C, GLU216D, GLU24C, GLU24D, GLU267C, GLU267D, GLU38C, GLU38D, GLY152C, GLY152D, GLY160C, GLY160D, GLY208C, GLY208D, GLY261D, GLY81C, GLY81D, HIS121C, HIS121D, HIS123C, HIS123D, HIS218C, HIS218D, HIS251C, HIS252C, HIS252D, HIS37C, HIS37D, ILE118C, ILE118D, ILE181C, ILE181D, ILE39C, ILE39D, LEU153C, LEU153D, LEU156C, LEU156D, LEU182C, LEU182D, LEU210C, LEU210D, LEU211C, LEU211D, LEU254C, LEU254D, LEU257C, LEU257D, LEU27C, LEU27D, LEU42C, LEU42D, LYS129C, LYS129D, LYS157C, LYS157D, LYS212C, LYS212D, LYS250C, LYS250D, LYS29C, LYS29D, LYS71C, LYS71D, MET229C, PHE113C, PHE113D, PHE114C, PHE114D, PHE125C, PHE125D, PHE214C, PHE214D, PHE253C, PHE253D, PHE260C, PHE260D, PHE269C, PHE269D, PHE77C, PHE77D, PHE82C, PHE82D, PHE88C, PHE88D, PRO259C, PRO259D, PRO265C, PRO265D, SER126C, SER126D, SER130C, SER130D, SER158C, SER158D, SER161C, SER161D, SER219C, SER219D, THR154C, THR154D, THR159C, THR159D, THR184C, THR184D, THR217C, THR217D, THR31C, THR31D, THR34D, THR69C, THR69D, THR73C, THR73D, TRP115C, TRP115D, TYR270C, TYR270D, TYR75C, TYR75D, VAL132C, VAL132D, VAL155C, VAL155D, VAL186C, VAL186D, VAL255C, VAL255D, VAL25C, VAL25D, VAL268C, VAL268D, VAL28C, VAL28D, VAL30C, VAL30D, VAL74C, VAL74D
• C-E: ARG168C, GLN175C, GLN175E, GLN258C, GLN258E, GLY261C, GLY261E, LYS170C, LYS170E, THR172C, THR172E, THR173C, THR173E
• C-G: ASP256G, GLN258C, GLN258G, GLN262C, GLN262G, GLY261C, GLY261G, LEU257C, LEU257G, PHE260C, PHE260G, PRO259C, PRO259G
• D-G: ASN72D, ASP263G, GLN258G, PHE100D
• E-F: ALA124E, ALA124F, ALA183E, ALA183F, ALA213E, ALA213F, ALA215E, ALA215F, ALA271E, ALA271F, ALA272E, ALA272F, ALA35E, ALA35F, ALA76E, ALA76F, ALA78E, ALA78F, ARG117E, ARG117F, ARG127E, ARG127F, ARG180E, ARG180F, ARG207E, ARG207F, ARG26E, ARG26F, ARG32E, ARG32F, ARG36F, ARG79E, ARG79F, ARG91E, ARG91F, ASN119E, ASN119F, ASN128E, ASN128F, ASN264E, ASN264F, ASN266E, ASN266F, ASN33E, ASN33F, ASN43E, ASN43F, ASN72E, ASN72F, ASP116E, ASP116F, ASP122E, ASP122F, ASP179E, ASP179F, ASP185E, ASP185F, ASP256E, ASP256F, ASP263E, ASP263F, ASP273E, ASP273F, ASP41E, ASP41F, ASP68E, ASP68F, ASP80E, ASP80F, GLN262E, GLN262F, GLN40E, GLN40F, GLU131E, GLU131F, GLU151E, GLU151F, GLU216E, GLU216F, GLU24E, GLU24F, GLU267E, GLU267F, GLU38E, GLU38F, GLY152E, GLY152F, GLY160E, GLY160F, GLY208E, GLY208F, GLY261F, GLY81E, GLY81F, HIS121E, HIS121F, HIS123E, HIS123F, HIS218E, HIS218F, HIS251E, HIS251F, HIS252E, HIS252F, HIS37E, HIS37F, ILE118E, ILE118F, ILE181E, ILE181F, ILE39E, ILE39F, LEU153E, LEU153F, LEU156E, LEU156F, LEU182E, LEU182F, LEU210E, LEU210F, LEU211E, LEU211F, LEU254E, LEU254F, LEU257E, LEU257F, LEU27E, LEU27F, LEU42E, LEU42F, LYS129E, LYS129F, LYS157E, LYS157F, LYS212E, LYS212F, LYS250E, LYS250F, LYS29E, LYS29F, LYS71E, LYS71F, PHE113E, PHE113F, PHE114E, PHE114F, PHE125E, PHE125F, PHE214E, PHE214F, PHE253E, PHE253F, PHE260E, PHE260F, PHE269E, PHE269F, PHE77E, PHE77F, PHE82E, PHE82F, PHE88E, PHE88F, PRO259E, PRO259F, PRO265E, PRO265F, SER126E, SER126F, SER130E, SER130F, SER158E, SER158F, SER161E, SER161F, SER219E, SER219F, THR154E, THR154F, THR159E, THR159F, THR184E, THR184F, THR217E, THR217F, THR31E, THR31F, THR69E, THR69F, THR73E, THR73F, TRP115E, TRP115F, TYR270E, TYR270F, TYR75E, TYR75F, VAL132E, VAL132F, VAL155E, VAL155F, VAL186E, VAL186F, VAL255E, VAL255F, VAL25E, VAL25F, VAL268E, VAL268F, VAL28E, VAL28F, VAL30E, VAL30F, VAL74E, VAL74F
• E-G: ALA271E, ALA271G, ALA272E, ALA272G, ARG274E, ARG274G, ASP169E, ASP169G, ASP256E, ASP256G, ASP273E, ASP273G, GLN262E, GLN262G, GLY261E, GLY261G, LEU174E, LEU174G, LEU257E, LEU257G, LYS170E, LYS170G, LYS250G, PHE253E, PHE253G, PHE260E, PHE260G, PRO259E, PRO259G, PRO275E, PRO275G, THR172E, THR172G, THR173E, THR173G, TYR171E, TYR171G, TYR270E, TYR270G, TYR276E, TYR276G
• E-H: ALA221E, ALA221H, ALA232E, ALA232H, ALA23E, ALA23H, ALA281E, ALA281H, ALA290E, ALA290H, ALA54E, ALA54H, ALA55E, ALA55H, ALA58E, ALA58H, ALA62E, ALA62H, ALA66E, ALA66H, ALA76E, ALA76H, ARG107E, ARG107H, ARG168E, ARG168H, ARG180E, ARG180H, ARG231E, ARG231H, ARG26E, ARG26H, ARG274E, ARG274H, ARG285E, ARG285H, ARG49E, ARG49H, ARG79E, ARG91E, ARG91H, ASN18E, ASN18H, ASN249E, ASN249H, ASN297E, ASN297H, ASN43E, ASN43H, ASN61E, ASN61H, ASN72E, ASN72H, ASP169E, ASP169H, ASP241E, ASP241H, ASP273E, ASP273H, ASP291E, ASP291H, ASP60E, ASP60H, ASP68E, ASP68H, ASP80E, ASP80H, GLN111E, GLN111H, GLN175E, GLN175H, GLN17E, GLN17H, GLN19E, GLN19H, GLN223E, GLN223H, GLN224E, GLN224H, GLN284E, GLN284H, GLN47E, GLN47H, GLN70E, GLN70H, GLU162E, GLU162H, GLU176E, GLU176H, GLU228E, GLU228H, GLU235E, GLU235H, GLU242E, GLU242H, GLU24E, GLU24H, GLU280E, GLU280H, GLU286E, GLU286H, GLU53E, GLU53H, GLY165E, GLY165H, GLY16E, GLY16H, GLY21E, GLY21H, GLY230E, GLY230H, GLY277E, GLY277H, GLY287E, GLY287H, GLY59E, GLY59H, GLY99E, GLY99H, HIS164E, HIS164H, HIS218E, HIS218H, HIS237E, HIS251E, HIS251H, HIS292E, HIS292H, HIS56E, HIS56H, HIS63E, HIS63H, HIS95E, HIS95H, ILE234E, ILE234H, ILE243E, ILE243H, ILE279E, ILE279H, ILE283E, ILE283H, LEU15E, LEU15H, LEU174E, LEU174H, LEU220E, LEU220H, LEU222E, LEU222H, LEU247E, LEU247H, LEU278E, LEU278H, LEU42E, LEU42H, LEU48E, LEU48H, LYS12E, LYS12H, LYS170E, LYS170H, LYS22E, LYS22H, LYS244E, LYS244H, LYS71E, LYS71H, MET226E, MET226H, MET245E, MET245H, PHE100E, PHE100H, PHE113E, PHE113H, PHE163E, PHE163H, PHE166E, PHE166H, PHE253E, PHE253H, PHE52E, PHE52H, PHE77E, PHE77H, PHE96E, PHE96H, PRO167E, PRO167H, PRO238E, PRO238H, PRO248E, PRO248H, PRO275E, PRO275H, PRO293H, SER219E, SER219H, SER246E, SER246H, SER288E, SER288H, SER296E, SER296H, SER46E, SER46H, THR11E, THR11H, THR172E, THR172H, THR173E, THR173H, THR177E, THR177H, THR225E, THR225H, THR236E, THR236H, THR282E, THR282H, THR45E, THR45H, THR57E, THR57H, THR67E, THR67H, THR69E, THR69H, THR73E, THR73H, TRP102E, TRP102H, TRP295E, TRP295H, TYR171E, TYR171H, TYR20E, TYR20H, TYR227E, TYR227H, TYR276E, TYR276H, TYR75E, TYR75H, VAL103E, VAL103H, VAL13E, VAL13H, VAL14E, VAL14H, VAL233E, VAL233H, VAL25E, VAL25H, VAL44E, VAL44H, VAL64E, VAL64H, VAL65E, VAL65H, VAL74E, VAL74H
• F-G: ALA221F, ALA221G, ALA232F, ALA232G, ALA23F, ALA23G, ALA281F, ALA281G, ALA290F, ALA290G, ALA54F, ALA54G, ALA55F, ALA55G, ALA58F, ALA58G, ALA62F, ALA62G, ALA66F, ALA66G, ALA76F, ALA76G, ARG107F, ARG107G, ARG168F, ARG168G, ARG180F, ARG180G, ARG231F, ARG231G, ARG26F, ARG26G, ARG274F, ARG274G, ARG285F, ARG285G, ARG289G, ARG49F, ARG49G, ARG79G, ARG91F, ARG91G, ASN18F, ASN18G, ASN249F, ASN249G, ASN297F, ASN297G, ASN43F, ASN43G, ASN61F, ASN61G, ASN72F, ASN72G, ASP169F, ASP169G, ASP241F, ASP241G, ASP273F, ASP273G, ASP291F, ASP291G, ASP60F, ASP60G, ASP68F, ASP68G, ASP80F, ASP80G, GLN111F, GLN111G, GLN175F, GLN175G, GLN17F, GLN17G, GLN19F, GLN19G, GLN223F, GLN223G, GLN224F, GLN224G, GLN284F, GLN284G, GLN47F, GLN47G, GLN70F, GLN70G, GLU162F, GLU162G, GLU176F, GLU176G, GLU228F, GLU228G, GLU235F, GLU235G, GLU242F, GLU242G, GLU24F, GLU24G, GLU280F, GLU280G, GLU286F, GLU286G, GLU53F, GLU53G, GLY165F, GLY165G, GLY16F, GLY16G, GLY21F, GLY21G, GLY230F, GLY230G, GLY277F, GLY277G, GLY287F, GLY287G, GLY59F, GLY59G, GLY99F, GLY99G, HIS164F, HIS164G, HIS218F, HIS218G, HIS237F, HIS251F, HIS251G, HIS292G, HIS56F, HIS56G, HIS63F, HIS63G, HIS95F, HIS95G, ILE234F, ILE234G, ILE243F, ILE243G, ILE279F, ILE279G, ILE283F, ILE283G, LEU15F, LEU15G, LEU174F, LEU174G, LEU220F, LEU220G, LEU222F, LEU222G, LEU247F, LEU247G, LEU278F, LEU278G, LEU42F, LEU42G, LEU48F, LEU48G, LYS12F, LYS12G, LYS170F, LYS170G, LYS22F, LYS22G, LYS244F, LYS244G, LYS71F, LYS71G, MET226F, MET226G, MET245F, MET245G, PHE100F, PHE100G, PHE113F, PHE113G, PHE163F, PHE163G, PHE166F, PHE166G, PHE253F, PHE253G, PHE52F, PHE52G, PHE77F, PHE77G, PHE96F, PHE96G, PRO167F, PRO167G, PRO238F, PRO238G, PRO248F, PRO248G, PRO275F, PRO275G, PRO293F, PRO293G, SER219F, SER219G, SER246F, SER246G, SER288F, SER288G, SER296F, SER296G, SER46F, SER46G, THR11F, THR11G, THR172F, THR172G, THR173F, THR173G, THR177F, THR177G, THR225F, THR225G, THR236F, THR236G, THR282F, THR282G, THR45F, THR45G, THR57F, THR57G, THR67F, THR67G, THR69F, THR69G, THR73F, THR73G, TRP102F, TRP102G, TRP295F, TRP295G, TYR171F, TYR171G, TYR20F, TYR20G, TYR227F, TYR227G, TYR276F, TYR276G, TYR75F, TYR75G, VAL103F, VAL103G, VAL13F, VAL13G, VAL14F, VAL14G, VAL233F, VAL233G, VAL25F, VAL25G, VAL44F, VAL44G, VAL64F, VAL64G, VAL65F, VAL65G, VAL74F, VAL74G
• F-H: ALA271F, ALA271H, ALA272F, ALA272H, ARG274F, ARG274H, ASP169F, ASP169H, ASP256F, ASP256H, ASP273F, ASP273H, GLN262F, GLN262H, GLY261F, GLY261H, LEU174F, LEU174H, LEU257F, LEU257H, LYS170F, LYS170H, LYS250F, LYS250H, PHE253F, PHE253H, PHE260F, PHE260H, PRO259F, PRO259H, PRO275F, PRO275H, THR172F, THR172H, THR173F, THR173H, TYR171F, TYR171H, TYR270F, TYR270H, TYR276F, TYR276H
• G-H: ALA124G, ALA124H, ALA183G, ALA183H, ALA213G, ALA213H, ALA215G, ALA215H, ALA271G, ALA271H, ALA272G, ALA272H, ALA35G, ALA35H, ALA76G, ALA76H, ALA78G, ALA78H, ARG117G, ARG117H, ARG127G, ARG127H, ARG180G, ARG180H, ARG207G, ARG207H, ARG26G, ARG26H, ARG32G, ARG32H, ARG36H, ARG79G, ARG79H, ARG91G, ARG91H, ASN119G, ASN119H, ASN128G, ASN128H, ASN264G, ASN264H, ASN266G, ASN266H, ASN33G, ASN33H, ASN43G, ASN43H, ASN72G, ASN72H, ASP116G, ASP116H, ASP122G, ASP122H, ASP179G, ASP179H, ASP185G, ASP185H, ASP256G, ASP256H, ASP263G, ASP263H, ASP273G, ASP273H, ASP41G, ASP41H, ASP68G, ASP68H, ASP80G, ASP80H, GLN262G, GLN262H, GLN40G, GLN40H, GLU131G, GLU131H, GLU151G, GLU151H, GLU216G, GLU216H, GLU24G, GLU24H, GLU267G, GLU267H, GLU38G, GLU38H, GLY152G, GLY152H, GLY160G, GLY160H, GLY208G, GLY208H, GLY261G, GLY261H, GLY81G, GLY81H, HIS121G, HIS121H, HIS123G, HIS123H, HIS218G, HIS218H, HIS251G, HIS252G, HIS252H, HIS37G, HIS37H, ILE118G, ILE118H, ILE181G, ILE181H, ILE39G, ILE39H, LEU153G, LEU153H, LEU156G, LEU156H, LEU182G, LEU182H, LEU210G, LEU210H, LEU211G, LEU211H, LEU254G, LEU254H, LEU257G, LEU257H, LEU27G, LEU27H, LEU42G, LEU42H, LYS129G, LYS129H, LYS157G, LYS157H, LYS212G, LYS212H, LYS250G, LYS250H, LYS29G, LYS29H, LYS71G, LYS71H, PHE113G, PHE113H, PHE114G, PHE114H, PHE125G, PHE125H, PHE214G, PHE214H, PHE253G, PHE253H, PHE260G, PHE260H, PHE269G, PHE269H, PHE77G, PHE77H, PHE82G, PHE82H, PHE88G, PHE88H, PRO259G, PRO259H, PRO265G, PRO265H, SER126G, SER126H, SER130G, SER130H, SER158G, SER158H, SER161G, SER161H, SER219G, SER219H, THR154G, THR154H, THR159G, THR159H, THR184G, THR184H, THR217G, THR217H, THR31G, THR31H, THR69G, THR69H, THR73G, THR73H, TRP115G, TRP115H, TYR270G, TYR270H, TYR75G, TYR75H, VAL132G, VAL132H, VAL155G, VAL155H, VAL186G, VAL186H, VAL255G, VAL255H, VAL25G, VAL25H, VAL268G, VAL268H, VAL28G, VAL28H, VAL30G, VAL30H, VAL74G, VAL74H