2YI2

grapevine fanleaf virus

• Total interactions analyzed: 190
• Total true interactions: 45
• Strongest Interaction:
  • Chains: F-J
  • Int. Res.: 205
  • Norm. En. per Res.: -4.0873
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-132.8123	-44.0936	-593.296	-770.2019	202	32	12	24023	8	49	48
A-C	0.0	0.0	-0.2524	-0.2524	5	0	0	51	0	1	2
A-D	0.0	0.0	-0.2146	-0.2146	5	0	0	44	0	1	2
A-E	-114.9694	-32.1557	-593.732	-740.8571	199	24	12	23684	9	48	47
B-C	-131.0497	-36.0519	-637.026	-804.1276	203	32	12	24605	9	48	48
B-D	0.0	0.0	-0.2254	-0.2254	5	0	0	44	0	1	2
B-E	0.0	0.0	-0.2338	-0.2338	5	0	0	48	0	1	2
C-D	-123.0498	-36.8639	-617.829	-777.7427	201	29	12	24161	9	48	48
C-E	0.0	0.0	-0.2574	-0.2574	5	0	0	52	0	1	2
C-S	0.0	5.5172			4
C-T	-21.8888	-17.2994			10
D-E	-107.632	-36.2183	-601.923	-745.7733	200	21	12	23797	9	48	47
D-M	0.0	5.5968	-59.7992	-54.2024	23	0	1	2196	0	10	9
D-N	-16.043	-17.2133			8
D-S	-28.8491	-17.9826			12
E-M	-21.9309	-16.7621	-273.992	-312.6851	96	13	13	11627	1	16	12
F-G	-118.0798	-21.5514	-616.879	-756.5102	205	32	12	24349	7	48	48
F-H	0.0	0.0	-0.3514	-0.3514	5	0	0	63	0	2	2
F-I	0.0	0.0	-0.3897	-0.3897	5	0	0	66	0	2	2
F-J	-157.0456	-25.5646	-655.289	-837.8992	205	39	12	24981	9	50	47
G-H	-135.4628	-40.447	-654.283	-830.1929	204	39	13	25163	9	50	49
G-I	0.0	0.0	-0.3804	-0.3804	5	0	0	62	0	2	2
G-J	0.0	0.0	-0.35	-0.35	5	0	0	61	0	2	2
H-I	-130.4921	-29.9581	-632.917	-793.3672	203	41	12	24721	9	50	47
H-J	0.0	0.0	-0.3913	-0.3913	5	0	0	65	0	2	2
H-K	-24.4088	-17.6717	-274.695	-316.7755	102	25	14	12235	1	17	11
H-O	-5.4744	6.2227			5
I-J	-116.6757	-43.4387	-628.756	-788.8704	199	27	13	24226	9	48	48
I-O	-34.27	-20.197			11
I-Q	0.0	6.0911			4
I-R	-28.9741	-18.8401			12
J-Q	-31.4899	-18.2379			11
K-L	-122.3172	-37.7915	-602.521	-762.6297	201	31	12	23968	9	49	47
K-O	-128.9182	-33.0324			49
L-M	-132.2945	-49.4666	-421.739	-603.5002	161	15	9	16411	7	32	25
M-N	-136.7533	-32.3452			46
N-O	-119.1686	-34.9631			46
N-R	0.0	5.3813			4
N-S	-31.0082	-17.4851			14
O-R	-24.0903	-15.9035			9
P-Q	-121.953	-34.023			47
P-T	-128.6499	-39.8464			48
Q-R	-124.2271	-44.038			47
R-S	-117.806	-29.6676			46
S-T	-110.01	-34.7856			45

Interface residues

• A-B: ALA117A, ALA159A, ALA292B, ALA296B, ALA387B, ALA388B, ALA429A, ALA43A, ALA440A, ALA456A, ALA458A, ARG26A, ARG284B, ARG289B, ARG293B, ARG469A, ARG485B, ARG491A, ASN256B, ASN263B, ASN384B, ASN409B, ASN454A, ASP261B, ASP337B, ASP345B, ASP346B, ASP352B, ASP359A, ASP427A, ASP433A, ASP476A, CYS225B, CYS488B, GLN206B, GLN298B, GLN405B, GLN442A, GLN442B, GLN477A, GLU158A, GLU254B, GLU264B, GLU344B, GLU383B, GLU38A, GLU411A, GLU411B, GLU445B, GLU449A, GLY205B, GLY228B, GLY230B, GLY231B, GLY257B, GLY270B, GLY297B, GLY34A, GLY382B, GLY398A, GLY413A, GLY413B, GLY417A, GLY426A, GLY431A, GLY434A, GLY446B, GLY44A, GLY453A, GLY457A, HIS116A, HIS288B, HIS437A, ILE283B, ILE41A, ILE421A, ILE441A, ILE441B, ILE481B, LEU163A, LEU227B, LEU265B, LEU294B, LEU295B, LEU338B, LEU340B, LEU395A, LEU404B, LEU408A, LEU408B, LEU424A, LEU432A, LEU444A, LEU444B, LEU451A, LEU45A, LEU466A, LEU475A, LEU484B, LEU487B, LYS121A, LYS214B, LYS267B, LYS282B, LYS33A, LYS360A, LYS39A, LYS403B, LYS414A, LYS414B, LYS423A, LYS428A, LYS443A, LYS443B, LYS474A, LYS482B, LYS489B, MET118A, MET229B, MET260B, MET303B, MET381B, MET430A, PHE120A, PHE125A, PHE162A, PHE266B, PHE343B, PHE348B, PHE386B, PHE412A, PHE412B, PHE439A, PHE455A, PHE464A, PRO172B, PRO269B, PRO286B, PRO291B, PRO341B, PRO385B, PRO435A, PRO460A, SER122A, SER161A, SER220B, SER224B, SER253B, SER285B, SER304B, SER339B, SER342B, SER367A, SER397A, SER407B, SER415A, SER415B, SER416A, SER418A, SER436A, SER465A, SER468A, SER480B, THR123A, THR124A, THR160A, THR203B, THR221B, THR258B, THR259B, THR290B, THR410A, THR410B, THR420A, THR422A, THR42A, THR448A, TRP119A, TRP250B, TRP255B, TRP350B, TRP406B, TRP40A, TRP470A, TYR216B, TYR268B, TYR287B, TYR347B, TYR37A, TYR467A, VAL207B, VAL223B, VAL226B, VAL349B, VAL399A, VAL419A, VAL425A, VAL438A, VAL452A, VAL46A, VAL483B, VAL486B
• A-C: GLN442A, GLY413A, GLY413C, PHE412A, PHE412C
• A-D: GLN442D, GLY413A, GLY413D, PHE412A, PHE412D
• A-E: ALA117E, ALA159E, ALA292A, ALA296A, ALA387A, ALA388A, ALA429E, ALA43E, ALA440E, ALA456E, ALA458E, ARG26E, ARG284A, ARG289A, ARG293A, ARG469E, ARG485A, ARG491E, ASN256A, ASN263A, ASN384A, ASN409A, ASN454E, ASP261A, ASP337A, ASP345A, ASP346A, ASP352A, ASP359E, ASP427E, ASP433E, ASP476E, CYS225A, CYS488A, GLN206A, GLN298A, GLN405A, GLN442A, GLN442E, GLN477E, GLU158E, GLU254A, GLU264A, GLU344A, GLU383A, GLU38E, GLU411A, GLU411E, GLU445A, GLU449E, GLY205A, GLY228A, GLY230A, GLY231A, GLY257A, GLY270A, GLY297A, GLY382A, GLY398E, GLY413A, GLY413E, GLY417E, GLY426E, GLY431E, GLY434E, GLY446A, GLY44E, GLY453E, GLY457E, HIS116E, HIS288A, HIS437E, ILE283A, ILE41E, ILE421E, ILE441A, ILE441E, ILE481A, LEU163E, LEU227A, LEU265A, LEU294A, LEU295A, LEU338A, LEU340A, LEU395E, LEU404A, LEU408A, LEU408E, LEU424E, LEU432E, LEU444A, LEU444E, LEU451E, LEU45E, LEU466E, LEU475E, LEU484A, LEU487A, LYS121E, LYS214A, LYS267A, LYS282A, LYS33E, LYS360E, LYS39E, LYS403A, LYS414A, LYS414E, LYS423E, LYS428E, LYS443A, LYS443E, LYS474E, LYS482A, LYS489A, MET118E, MET229A, MET260A, MET303A, MET381A, MET430E, PHE120E, PHE125E, PHE162E, PHE266A, PHE343A, PHE348A, PHE386A, PHE412A, PHE412E, PHE439E, PHE455E, PHE464E, PRO172A, PRO269A, PRO286A, PRO291A, PRO341A, PRO385A, PRO435E, PRO460E, SER122E, SER161E, SER220A, SER224A, SER253A, SER285A, SER304A, SER339A, SER342A, SER367E, SER397E, SER407A, SER415A, SER415E, SER416E, SER418E, SER436E, SER465E, SER468E, SER480A, THR123E, THR124E, THR160E, THR203A, THR221A, THR258A, THR259A, THR290A, THR410A, THR420E, THR422E, THR42E, THR448E, TRP119E, TRP250A, TRP255A, TRP350A, TRP406A, TRP40E, TRP470E, TYR216A, TYR268A, TYR287A, TYR347A, TYR37E, TYR467E, VAL207A, VAL223A, VAL226A, VAL349A, VAL399E, VAL419E, VAL425E, VAL438E, VAL452E, VAL483A, VAL486A
• B-C: ALA117B, ALA159B, ALA292C, ALA296C, ALA387C, ALA388C, ALA429B, ALA43B, ALA440B, ALA456B, ALA458B, ARG26B, ARG284C, ARG289C, ARG293C, ARG469B, ARG485C, ARG491B, ASN256C, ASN263C, ASN384C, ASN409C, ASN454B, ASP261C, ASP337C, ASP345C, ASP346C, ASP352C, ASP359B, ASP427B, ASP433B, ASP476B, CYS225C, CYS488C, GLN206C, GLN298C, GLN405C, GLN442B, GLN442C, GLN477B, GLU158B, GLU254C, GLU264C, GLU344C, GLU383C, GLU38B, GLU411B, GLU411C, GLU445C, GLU449B, GLY173C, GLY205C, GLY228C, GLY230C, GLY231C, GLY257C, GLY270C, GLY297C, GLY382C, GLY398B, GLY413B, GLY413C, GLY417B, GLY426B, GLY431B, GLY434B, GLY446C, GLY44B, GLY453B, GLY457B, HIS116B, HIS288C, HIS437B, ILE283C, ILE41B, ILE421B, ILE441B, ILE441C, ILE481C, LEU163B, LEU227C, LEU265C, LEU294C, LEU295C, LEU338C, LEU340C, LEU395B, LEU404C, LEU408B, LEU408C, LEU424B, LEU432B, LEU444B, LEU444C, LEU451B, LEU45B, LEU466B, LEU475B, LEU484C, LEU487C, LYS121B, LYS214C, LYS267C, LYS282C, LYS33B, LYS360B, LYS39B, LYS403C, LYS414B, LYS414C, LYS423B, LYS428B, LYS443B, LYS443C, LYS474B, LYS482C, LYS489C, MET118B, MET229C, MET260C, MET303C, MET381C, MET430B, PHE120B, PHE125B, PHE162B, PHE266C, PHE343C, PHE348C, PHE386C, PHE412B, PHE412C, PHE439B, PHE455B, PHE464B, PRO172C, PRO269C, PRO286C, PRO291C, PRO341C, PRO385C, PRO435B, PRO460B, SER122B, SER161B, SER220C, SER224C, SER253C, SER285C, SER304C, SER339C, SER342C, SER367B, SER397B, SER407C, SER415B, SER415C, SER416B, SER418B, SER436B, SER465B, SER468B, SER480C, THR123B, THR124B, THR160B, THR203C, THR221C, THR258C, THR259C, THR290C, THR410B, THR410C, THR420B, THR422B, THR42B, THR448B, TRP119B, TRP250C, TRP255C, TRP350C, TRP406C, TRP40B, TRP470B, TYR216C, TYR268C, TYR287C, TYR347C, TYR37B, TYR467B, TYR497B, VAL207C, VAL223C, VAL226C, VAL349C, VAL399B, VAL419B, VAL425B, VAL438B, VAL452B, VAL46B, VAL483C, VAL486C
• B-D: GLN442B, GLY413B, GLY413D, PHE412B, PHE412D
• B-E: GLN442E, GLY413B, GLY413E, PHE412B, PHE412E
• C-D: ALA117C, ALA159C, ALA292D, ALA296D, ALA387D, ALA388D, ALA429C, ALA43C, ALA440C, ALA456C, ALA458C, ARG26C, ARG284D, ARG289D, ARG293D, ARG469C, ARG485D, ARG491C, ASN256D, ASN263D, ASN384D, ASN409D, ASN454C, ASP261D, ASP337D, ASP345D, ASP346D, ASP352D, ASP359C, ASP427C, ASP433C, ASP476C, CYS225D, CYS488D, GLN206D, GLN298D, GLN405D, GLN442C, GLN442D, GLN477C, GLU158C, GLU254D, GLU264D, GLU344D, GLU383D, GLU38C, GLU411C, GLU411D, GLU445D, GLU449C, GLY173D, GLY205D, GLY228D, GLY230D, GLY231D, GLY257D, GLY270D, GLY297D, GLY382D, GLY398C, GLY413C, GLY413D, GLY417C, GLY426C, GLY431C, GLY434C, GLY446D, GLY44C, GLY453C, GLY457C, HIS116C, HIS288D, HIS437C, ILE283D, ILE41C, ILE421C, ILE441C, ILE441D, ILE481D, LEU163C, LEU227D, LEU265D, LEU294D, LEU295D, LEU338D, LEU340D, LEU395C, LEU404D, LEU408C, LEU408D, LEU424C, LEU432C, LEU444C, LEU444D, LEU451C, LEU45C, LEU466C, LEU475C, LEU484D, LEU487D, LYS121C, LYS214D, LYS267D, LYS282D, LYS33C, LYS360C, LYS39C, LYS403D, LYS414C, LYS414D, LYS423C, LYS428C, LYS443C, LYS443D, LYS474C, LYS482D, LYS489D, MET118C, MET229D, MET260D, MET303D, MET381D, MET430C, PHE120C, PHE125C, PHE162C, PHE266D, PHE343D, PHE348D, PHE386D, PHE412C, PHE412D, PHE439C, PHE455C, PHE464C, PRO172D, PRO269D, PRO286D, PRO291D, PRO341D, PRO385D, PRO435C, PRO460C, SER122C, SER161C, SER220D, SER224D, SER253D, SER285D, SER304D, SER339D, SER342D, SER367C, SER397C, SER407D, SER415C, SER415D, SER416C, SER418C, SER436C, SER465C, SER468C, SER480D, THR123C, THR124C, THR160C, THR203D, THR221D, THR258D, THR259D, THR290D, THR410D, THR420C, THR422C, THR42C, THR448C, TRP119C, TRP250D, TRP255D, TRP350D, TRP406D, TRP40C, TRP470C, TYR216D, TYR268D, TYR287D, TYR347D, TYR37C, TYR467C, VAL207D, VAL223D, VAL226D, VAL349D, VAL399C, VAL419C, VAL425C, VAL438C, VAL452C, VAL46C, VAL483D, VAL486D
• C-E: GLN442C, GLY413C, GLY413E, PHE412C, PHE412E
• C-S: GLU38C, GLU38S, LYS33C, LYS33S
• C-T: ALA143C, ALA316T, ALA58C, ARG55C, ASN59C, GLU274T, LYS267T, LYS33C, PHE244T, SER246T
• D-E: ALA117D, ALA159D, ALA292E, ALA296E, ALA387E, ALA388E, ALA429D, ALA43D, ALA440D, ALA456D, ALA458D, ARG26D, ARG284E, ARG289E, ARG293E, ARG469D, ARG485E, ARG491D, ASN256E, ASN263E, ASN384E, ASN409E, ASN454D, ASP261E, ASP337E, ASP345E, ASP346E, ASP352E, ASP359D, ASP427D, ASP433D, ASP476D, CYS225E, CYS488E, GLN206E, GLN298E, GLN405E, GLN442D, GLN442E, GLN477D, GLU158D, GLU254E, GLU264E, GLU344E, GLU383E, GLU38D, GLU411D, GLU411E, GLU445E, GLU449D, GLY205E, GLY228E, GLY230E, GLY231E, GLY257E, GLY270E, GLY297E, GLY382E, GLY398D, GLY413D, GLY413E, GLY417D, GLY426D, GLY431D, GLY434D, GLY446E, GLY44D, GLY453D, GLY457D, HIS116D, HIS288E, HIS437D, ILE283E, ILE41D, ILE421D, ILE441D, ILE441E, ILE481E, LEU163D, LEU227E, LEU265E, LEU294E, LEU295E, LEU338E, LEU340E, LEU395D, LEU404E, LEU408D, LEU408E, LEU424D, LEU432D, LEU444D, LEU444E, LEU451D, LEU45D, LEU466D, LEU475D, LEU484E, LEU487E, LYS121D, LYS214E, LYS267E, LYS282E, LYS33D, LYS360D, LYS39D, LYS403E, LYS414D, LYS414E, LYS423D, LYS428D, LYS443D, LYS443E, LYS474D, LYS482E, LYS489E, MET118D, MET229E, MET260E, MET303E, MET381E, MET430D, PHE120D, PHE125D, PHE162D, PHE266E, PHE343E, PHE348E, PHE386E, PHE412D, PHE412E, PHE439D, PHE455D, PHE464D, PRO172E, PRO269E, PRO286E, PRO291E, PRO341E, PRO385E, PRO435D, PRO460D, SER122D, SER161D, SER220E, SER224E, SER253E, SER285E, SER304E, SER339E, SER342E, SER367D, SER397D, SER407E, SER415D, SER415E, SER416D, SER418D, SER436D, SER465D, SER468D, SER480E, THR123D, THR124D, THR160D, THR203E, THR221E, THR258E, THR259E, THR290E, THR410E, THR420D, THR422D, THR42D, THR448D, TRP119D, TRP250E, TRP255E, TRP350E, TRP406E, TRP40D, TRP470D, TYR216E, TYR268E, TYR287E, TYR347E, TYR37D, TYR467D, VAL207E, VAL223E, VAL226E, VAL349E, VAL399D, VAL419D, VAL425D, VAL438D, VAL452D, VAL46D, VAL483E, VAL486E
• D-M: GLN36D, GLN36M, GLU38D, GLU38M, GLY34D, GLY34M, ILE41D, ILE41M, LEU2M, LYS33D, LYS33M, LYS39D, LYS39M, PHE32D, PHE32M, THR42D, THR42M, TRP40D, TRP40M, TYR37D, TYR37M, VAL35D, VAL35M
• D-N: ALA143D, ALA316N, ARG55D, ASN59D, GLU274N, LYS267N, LYS33D, PHE244N
• D-S: ALA143S, ALA316D, ARG55S, ASN59S, GLU151S, GLU274D, LYS267D, LYS33S, PHE244D, PHE32S, THR103S, TYR272D
• E-M: ALA143M, ALA144M, ALA148M, ALA193E, ALA196E, ALA310E, ALA312E, ALA316E, ALA58M, ALA60E, ALA60M, ARG55M, ARG5M, ASN138M, ASN139M, ASN263E, ASN59M, ASP145M, ASP190E, ASP261E, ASP31M, GLN147M, GLN36M, GLU141M, GLU151M, GLU264E, GLU274E, GLU275E, GLU320E, GLU38M, GLY102M, GLY313E, GLY319E, GLY34M, GLY4M, GLY6M, HIS99M, ILE10M, ILE239E, ILE243E, ILE243M, ILE247E, ILE29M, ILE311E, ILE315E, ILE54M, ILE8M, LEU142M, LEU191E, LEU249E, LEU265E, LEU2M, LEU324E, LEU56M, LEU64M, LYS12M, LYS140M, LYS267E, LYS33M, MET28M, PHE244E, PHE244M, PHE266E, PHE32M, PHE61E, PHE61M, PRO11M, PRO242E, PRO314E, PRO317E, PRO57M, SER246E, SER318E, THR103M, THR192E, THR195E, THR321E, THR62M, TRP146M, TRP250E, TRP262E, TRP66M, TYR153M, TYR245E, TYR268E, TYR272E, TYR37M, TYR9M, VAL149M, VAL194E, VAL248E, VAL271E, VAL273E, VAL35M, VAL53M, VAL7M
• F-G: ALA117F, ALA159F, ALA292G, ALA296G, ALA387G, ALA388G, ALA429F, ALA43F, ALA440F, ALA456F, ALA458F, ARG26F, ARG284G, ARG289G, ARG293G, ARG335G, ARG469F, ARG485G, ARG491F, ASN256G, ASN263G, ASN384G, ASN409G, ASN454F, ASP261G, ASP337G, ASP345G, ASP346G, ASP352G, ASP359F, ASP427F, ASP433F, ASP476F, CYS225G, CYS488G, GLN206G, GLN298G, GLN405G, GLN442F, GLN442G, GLN477F, GLU158F, GLU254G, GLU264G, GLU344G, GLU383G, GLU38F, GLU411F, GLU411G, GLU445G, GLU449F, GLY173G, GLY205G, GLY228G, GLY230G, GLY231G, GLY257G, GLY270G, GLY297G, GLY34F, GLY382G, GLY398F, GLY413F, GLY413G, GLY417F, GLY426F, GLY431F, GLY434F, GLY446G, GLY44F, GLY453F, GLY457F, HIS116F, HIS288G, HIS437F, ILE283G, ILE41F, ILE421F, ILE441F, ILE441G, ILE481G, LEU163F, LEU227G, LEU265G, LEU294G, LEU295G, LEU338G, LEU340G, LEU395F, LEU404G, LEU408F, LEU408G, LEU424F, LEU432F, LEU444F, LEU444G, LEU451F, LEU45F, LEU466F, LEU475F, LEU484G, LEU487G, LYS121F, LYS214G, LYS267G, LYS282G, LYS33F, LYS360F, LYS39F, LYS403G, LYS414F, LYS414G, LYS423F, LYS428F, LYS443F, LYS443G, LYS474F, LYS482G, LYS489G, MET118F, MET229G, MET260G, MET303G, MET381G, MET430F, PHE120F, PHE125F, PHE162F, PHE266G, PHE343G, PHE348G, PHE386G, PHE412F, PHE412G, PHE439F, PHE455F, PHE464F, PRO172G, PRO269G, PRO286G, PRO291G, PRO341G, PRO385G, PRO435F, PRO460F, SER122F, SER161F, SER220G, SER224G, SER253G, SER285G, SER304G, SER339G, SER342G, SER367F, SER397F, SER407G, SER415F, SER415G, SER416F, SER418F, SER436F, SER465F, SER468F, SER480G, THR123F, THR124F, THR160F, THR203G, THR221G, THR258G, THR259G, THR290G, THR410G, THR420F, THR422F, THR42F, THR447F, THR448F, TRP119F, TRP250G, TRP255G, TRP350G, TRP406G, TRP40F, TRP470F, TYR216G, TYR268G, TYR287G, TYR347G, TYR37F, TYR467F, TYR497F, VAL207G, VAL223G, VAL226G, VAL349G, VAL399F, VAL419F, VAL425F, VAL438F, VAL452F, VAL46F, VAL483G, VAL486G
• F-H: GLN442F, GLY413F, GLY413H, PHE412F, PHE412H
• F-I: GLN442I, GLY413F, GLY413I, PHE412F, PHE412I
• F-J: ALA117J, ALA159J, ALA292F, ALA296F, ALA387F, ALA388F, ALA429J, ALA43J, ALA440J, ALA456J, ALA458J, ARG26J, ARG284F, ARG289F, ARG293F, ARG335F, ARG469J, ARG485F, ARG491J, ASN256F, ASN263F, ASN384F, ASN409F, ASN454J, ASP261F, ASP337F, ASP345F, ASP346F, ASP352F, ASP359J, ASP427J, ASP433J, ASP476J, CYS225F, CYS488F, GLN206F, GLN298F, GLN405F, GLN442F, GLN442J, GLN477J, GLU158J, GLU254F, GLU264F, GLU344F, GLU383F, GLU38J, GLU411F, GLU411J, GLU445F, GLU449J, GLY173F, GLY205F, GLY228F, GLY230F, GLY231F, GLY257F, GLY270F, GLY297F, GLY382F, GLY398J, GLY413F, GLY413J, GLY417J, GLY426J, GLY431J, GLY434J, GLY446F, GLY44J, GLY453J, GLY457J, HIS116J, HIS288F, HIS437J, ILE283F, ILE41J, ILE421J, ILE441F, ILE441J, ILE481F, LEU163J, LEU227F, LEU265F, LEU294F, LEU295F, LEU338F, LEU340F, LEU395J, LEU404F, LEU408F, LEU408J, LEU424J, LEU432J, LEU444F, LEU444J, LEU451J, LEU45J, LEU466J, LEU475J, LEU484F, LEU487F, LYS121J, LYS214F, LYS267F, LYS282F, LYS33J, LYS360J, LYS39J, LYS403F, LYS414F, LYS414J, LYS423J, LYS428J, LYS443F, LYS443J, LYS474J, LYS482F, LYS489F, MET118J, MET229F, MET260F, MET303F, MET381F, MET430J, PHE120J, PHE125J, PHE162J, PHE266F, PHE343F, PHE348F, PHE386F, PHE412F, PHE412J, PHE439J, PHE455J, PHE464J, PRO172F, PRO269F, PRO286F, PRO291F, PRO341F, PRO385F, PRO435J, PRO460J, SER122J, SER161J, SER220F, SER224F, SER253F, SER285F, SER304F, SER339F, SER342F, SER367J, SER397J, SER407F, SER415F, SER415J, SER416J, SER418J, SER436J, SER465J, SER468J, SER480F, THR123J, THR124J, THR160J, THR203F, THR221F, THR258F, THR259F, THR290F, THR410F, THR410J, THR420J, THR422J, THR42J, THR447J, THR448J, TRP119J, TRP250F, TRP255F, TRP350F, TRP406F, TRP40J, TRP470J, TYR216F, TYR268F, TYR287F, TYR347F, TYR37J, TYR467J, TYR497J, VAL207F, VAL223F, VAL226F, VAL349F, VAL399J, VAL419J, VAL425J, VAL438J, VAL452J, VAL46J, VAL483F, VAL486F
• G-H: ALA117G, ALA159G, ALA292H, ALA296H, ALA387H, ALA388H, ALA429G, ALA43G, ALA440G, ALA456G, ALA458G, ARG26G, ARG284H, ARG289H, ARG293H, ARG335H, ARG469G, ARG485H, ARG491G, ASN256H, ASN263H, ASN384H, ASN409H, ASN454G, ASP261H, ASP337H, ASP345H, ASP346H, ASP352H, ASP359G, ASP427G, ASP433G, ASP476G, CYS225H, CYS488H, GLN206H, GLN298H, GLN405H, GLN442G, GLN442H, GLN477G, GLU158G, GLU254H, GLU264H, GLU344H, GLU383H, GLU38G, GLU411G, GLU411H, GLU445H, GLU449G, GLY173H, GLY205H, GLY228H, GLY230H, GLY231H, GLY257H, GLY270H, GLY297H, GLY382H, GLY398G, GLY413G, GLY413H, GLY417G, GLY426G, GLY431G, GLY434G, GLY446H, GLY44G, GLY453G, GLY457G, HIS116G, HIS288H, HIS437G, ILE283H, ILE41G, ILE421G, ILE441G, ILE441H, ILE481H, LEU163G, LEU227H, LEU265H, LEU294H, LEU295H, LEU338H, LEU340H, LEU395G, LEU404H, LEU408G, LEU408H, LEU424G, LEU432G, LEU444G, LEU444H, LEU451G, LEU45G, LEU466G, LEU475G, LEU484H, LEU487H, LYS121G, LYS214H, LYS267H, LYS282H, LYS33G, LYS360G, LYS39G, LYS403H, LYS414G, LYS414H, LYS423G, LYS428G, LYS443G, LYS443H, LYS474G, LYS482H, LYS489H, MET118G, MET229H, MET260H, MET303H, MET381H, MET430G, PHE120G, PHE125G, PHE162G, PHE266H, PHE343H, PHE348H, PHE386H, PHE412G, PHE412H, PHE439G, PHE455G, PHE464G, PRO172H, PRO269H, PRO286H, PRO291H, PRO341H, PRO385H, PRO435G, PRO460G, SER122G, SER161G, SER220H, SER224H, SER253H, SER285H, SER304H, SER339H, SER342H, SER367G, SER397G, SER407H, SER415G, SER415H, SER416G, SER418G, SER436G, SER465G, SER468G, SER480H, THR123G, THR124G, THR160G, THR203H, THR221H, THR232H, THR258H, THR259H, THR290H, THR410H, THR420G, THR422G, THR42G, THR447G, THR448G, TRP119G, TRP250H, TRP255H, TRP350H, TRP406H, TRP40G, TRP470G, TYR216H, TYR268H, TYR287H, TYR347H, TYR37G, TYR467G, VAL207H, VAL223H, VAL226H, VAL349H, VAL399G, VAL419G, VAL425G, VAL438G, VAL452G, VAL46G, VAL483H, VAL486H
• G-I: GLN442G, GLY413G, GLY413I, PHE412G, PHE412I
• G-J: GLN442J, GLY413G, GLY413J, PHE412G, PHE412J
• H-I: ALA117H, ALA159H, ALA292I, ALA296I, ALA387I, ALA388I, ALA429H, ALA43H, ALA440H, ALA456H, ALA458H, ARG26H, ARG284I, ARG289I, ARG293I, ARG335I, ARG469H, ARG485I, ARG491H, ASN256I, ASN263I, ASN384I, ASN409I, ASN454H, ASP261I, ASP337I, ASP345I, ASP346I, ASP352I, ASP359H, ASP427H, ASP433H, ASP476H, CYS225I, CYS488I, GLN206I, GLN298I, GLN405I, GLN442H, GLN442I, GLN477H, GLU158H, GLU254I, GLU264I, GLU344I, GLU383I, GLU38H, GLU411H, GLU411I, GLU445I, GLU449H, GLY173I, GLY205I, GLY228I, GLY230I, GLY231I, GLY257I, GLY270I, GLY297I, GLY382I, GLY398H, GLY413H, GLY413I, GLY417H, GLY426H, GLY431H, GLY434H, GLY446I, GLY44H, GLY453H, GLY457H, HIS116H, HIS288I, HIS437H, ILE283I, ILE41H, ILE421H, ILE441H, ILE441I, ILE481I, LEU163H, LEU227I, LEU265I, LEU294I, LEU295I, LEU338I, LEU340I, LEU395H, LEU404I, LEU408H, LEU408I, LEU424H, LEU432H, LEU444H, LEU444I, LEU451H, LEU45H, LEU466H, LEU475H, LEU484I, LEU487I, LYS121H, LYS214I, LYS267I, LYS282I, LYS33H, LYS360H, LYS39H, LYS403I, LYS414H, LYS414I, LYS423H, LYS428H, LYS443H, LYS443I, LYS474H, LYS482I, LYS489I, MET118H, MET229I, MET260I, MET303I, MET381I, MET430H, PHE120H, PHE125H, PHE162H, PHE266I, PHE343I, PHE348I, PHE386I, PHE412H, PHE412I, PHE439H, PHE455H, PHE464H, PRO172I, PRO269I, PRO286I, PRO291I, PRO341I, PRO385I, PRO435H, PRO460H, SER122H, SER161H, SER220I, SER224I, SER253I, SER285I, SER304I, SER339I, SER342I, SER367H, SER397H, SER407I, SER415H, SER415I, SER416H, SER418H, SER436H, SER465H, SER468H, SER480I, THR123H, THR124H, THR160H, THR203I, THR221I, THR258I, THR259I, THR290I, THR410I, THR420H, THR422H, THR42H, THR447H, THR448H, TRP119H, TRP255I, TRP350I, TRP406H, TRP406I, TRP40H, TRP470H, TYR216I, TYR268I, TYR287I, TYR347I, TYR37H, TYR467H, TYR497H, VAL207I, VAL223I, VAL226I, VAL349I, VAL399H, VAL419H, VAL425H, VAL438H, VAL452H, VAL483I, VAL486I
• H-J: GLN442H, GLY413H, GLY413J, PHE412H, PHE412J
• H-K: ALA143H, ALA144H, ALA148H, ALA193K, ALA196K, ALA310K, ALA312K, ALA316K, ALA3H, ALA58H, ALA60H, ALA60K, ARG55H, ARG5H, ASN138H, ASN139H, ASN263K, ASN59H, ASP145H, ASP190K, ASP261K, ASP27H, ASP31H, GLN147H, GLN36H, GLU141H, GLU151H, GLU264K, GLU274K, GLU275K, GLU320K, GLU38H, GLY102H, GLY313K, GLY319K, GLY34H, GLY4H, GLY6H, HIS99H, ILE10H, ILE239K, ILE243H, ILE243K, ILE247K, ILE29H, ILE311K, ILE315K, ILE54H, ILE8H, LEU101H, LEU142H, LEU191K, LEU249K, LEU265K, LEU2H, LEU324K, LEU56H, LEU64H, LYS12H, LYS140H, LYS267K, LYS33H, MET28H, PHE104H, PHE244H, PHE244K, PHE266K, PHE32H, PHE61H, PHE61K, PRO11H, PRO242K, PRO314K, PRO317K, PRO57H, SER246K, SER30H, SER318K, THR103H, THR192K, THR195K, THR321K, THR62H, TRP146H, TRP250K, TRP262K, TRP66H, TYR153H, TYR245K, TYR268K, TYR272K, TYR37H, TYR9H, VAL149H, VAL150H, VAL194K, VAL248K, VAL271K, VAL273K, VAL35H, VAL53H, VAL7H
• H-O: GLU38H, GLU38O, GLY34H, LYS33H, LYS33O
• I-J: ALA117I, ALA159I, ALA292J, ALA296J, ALA387J, ALA388J, ALA429I, ALA43I, ALA440I, ALA456I, ALA458I, ARG26I, ARG284J, ARG289J, ARG293J, ARG469I, ARG485J, ARG491I, ASN256J, ASN263J, ASN384J, ASN409J, ASN454I, ASP261J, ASP337J, ASP345J, ASP346J, ASP352J, ASP359I, ASP427I, ASP433I, ASP476I, CYS225J, CYS488J, GLN206J, GLN298J, GLN405J, GLN442I, GLN442J, GLN477I, GLU158I, GLU254J, GLU264J, GLU344J, GLU383J, GLU38I, GLU411I, GLU411J, GLU445J, GLU449I, GLY205J, GLY228J, GLY230J, GLY257J, GLY270J, GLY297J, GLY382J, GLY398I, GLY413I, GLY413J, GLY417I, GLY426I, GLY431I, GLY434I, GLY446J, GLY44I, GLY453I, GLY457I, HIS116I, HIS288J, HIS437I, ILE283J, ILE41I, ILE421I, ILE441I, ILE441J, ILE481J, LEU163I, LEU227J, LEU265J, LEU294J, LEU295J, LEU338J, LEU340J, LEU395I, LEU404J, LEU408I, LEU408J, LEU424I, LEU432I, LEU444I, LEU444J, LEU451I, LEU45I, LEU466I, LEU475I, LEU484J, LEU487J, LYS121I, LYS214J, LYS267J, LYS282J, LYS33I, LYS360I, LYS39I, LYS403J, LYS414I, LYS414J, LYS423I, LYS428I, LYS443I, LYS443J, LYS474I, LYS482J, LYS489J, MET118I, MET229J, MET260J, MET303J, MET381J, MET430I, PHE120I, PHE125I, PHE162I, PHE266J, PHE343J, PHE348J, PHE386J, PHE412I, PHE412J, PHE439I, PHE455I, PHE464I, PRO172J, PRO269J, PRO286J, PRO291J, PRO341J, PRO385J, PRO435I, PRO460I, SER122I, SER161I, SER220J, SER224J, SER253J, SER285J, SER304J, SER339J, SER342J, SER367I, SER397I, SER407J, SER415I, SER415J, SER416I, SER418I, SER436I, SER465I, SER468I, SER480J, THR123I, THR124I, THR160I, THR203J, THR221J, THR258J, THR259J, THR290J, THR410I, THR410J, THR420I, THR422I, THR42I, THR447I, THR448I, TRP119I, TRP255J, TRP350J, TRP406J, TRP40I, TRP470I, TYR216J, TYR268J, TYR287J, TYR347J, TYR37I, TYR467I, VAL207J, VAL223J, VAL226J, VAL349J, VAL399I, VAL419I, VAL425I, VAL438I, VAL452I, VAL483J, VAL486J
• I-O: ALA143O, ALA316I, ARG55O, ASN59O, GLU141O, GLU274I, LYS267I, LYS33O, PHE244I, PHE32O, SER318I
• I-Q: GLU38I, GLU38Q, LYS33I, LYS33Q
• I-R: ALA143I, ALA316R, ARG55I, ARG5I, ASN59I, GLU141I, GLU274R, LYS267R, LYS33I, PHE244R, PHE32I, SER318R
• J-Q: ALA143Q, ALA316J, ARG55Q, ASN59Q, GLU141Q, GLU274J, LYS267J, LYS33Q, PHE244J, PHE32Q, SER318J
• K-L: ALA117K, ALA159K, ALA292L, ALA296L, ALA387L, ALA388L, ALA429K, ALA43K, ALA440K, ALA456K, ALA458K, ARG26K, ARG284L, ARG289L, ARG293L, ARG335L, ARG469K, ARG485L, ARG491K, ASN256L, ASN263L, ASN384L, ASN409L, ASN454K, ASP261L, ASP337L, ASP345L, ASP346L, ASP352L, ASP359K, ASP427K, ASP433K, ASP476K, CYS225L, CYS488L, GLN206L, GLN298L, GLN405L, GLN442K, GLN442L, GLN477K, GLU158K, GLU254L, GLU264L, GLU344L, GLU383L, GLU38K, GLU411K, GLU411L, GLU445L, GLU449K, GLY205L, GLY228L, GLY230L, GLY231L, GLY257L, GLY270L, GLY297L, GLY382L, GLY398K, GLY413K, GLY413L, GLY417K, GLY426K, GLY431K, GLY434K, GLY446L, GLY44K, GLY453K, GLY457K, HIS116K, HIS288L, HIS437K, ILE283L, ILE41K, ILE421K, ILE441K, ILE441L, ILE481L, LEU163K, LEU227L, LEU265L, LEU294L, LEU295L, LEU338L, LEU340L, LEU395K, LEU404L, LEU408K, LEU408L, LEU424K, LEU432K, LEU444K, LEU444L, LEU451K, LEU45K, LEU466K, LEU475K, LEU484L, LEU487L, LYS121K, LYS214L, LYS267L, LYS282L, LYS33K, LYS360K, LYS39K, LYS403L, LYS414K, LYS414L, LYS423K, LYS428K, LYS443K, LYS443L, LYS474K, LYS482L, LYS489L, MET118K, MET229L, MET260L, MET303L, MET381L, MET430K, PHE120K, PHE125K, PHE162K, PHE266L, PHE343L, PHE348L, PHE386L, PHE412K, PHE412L, PHE439K, PHE455K, PHE464K, PRO172L, PRO269L, PRO286L, PRO291L, PRO341L, PRO385L, PRO435K, PRO460K, SER122K, SER161K, SER220L, SER224L, SER253L, SER285L, SER304L, SER339L, SER342L, SER367K, SER397K, SER407L, SER415K, SER415L, SER416K, SER418K, SER436K, SER465K, SER468K, SER480L, THR123K, THR124K, THR160K, THR203L, THR221L, THR258L, THR259L, THR290L, THR410L, THR420K, THR422K, THR42K, THR447K, THR448K, TRP119K, TRP255L, TRP350L, TRP406K, TRP406L, TRP40K, TRP470K, TYR216L, TYR268L, TYR287L, TYR347L, TYR37K, TYR467K, VAL207L, VAL223L, VAL226L, VAL349L, VAL399K, VAL419K, VAL425K, VAL438K, VAL452K, VAL483L, VAL486L
• K-O: ALA296K, ARG284K, ARG289K, ARG293K, ARG469O, ARG485K, ASP346K, ASP352K, ASP427O, ASP433O, ASP476O, GLN405K, GLU158O, GLU254K, GLU264K, GLU344K, GLU383K, GLU38O, GLU411K, GLU411O, GLU445K, GLU449O, GLY413K, GLY413O, GLY417O, GLY434O, HIS437O, ILE41O, LEU408K, LYS121O, LYS267K, LYS282K, LYS403K, LYS414K, LYS414O, LYS423O, LYS443K, LYS443O, LYS482K, MET430O, PHE412K, PHE455O, PRO341K, SER339K, SER342K, SER415O, TYR467O, VAL349K, VAL438O
• L-M: ALA117L, ALA159L, ALA292M, ALA296M, ALA429L, ALA43L, ALA456L, ALA458L, ARG26L, ARG284M, ARG289M, ARG293M, ARG335M, ARG469L, ARG485M, ARG491L, ASN256M, ASN263M, ASN454L, ASP261M, ASP337M, ASP345M, ASP346M, ASP352M, ASP427L, ASP433L, ASP476L, CYS225M, GLN206M, GLN298M, GLN405M, GLU158L, GLU254M, GLU264M, GLU344M, GLU383M, GLU38L, GLU411L, GLU411M, GLU445M, GLU449L, GLY205M, GLY228M, GLY230M, GLY231M, GLY257M, GLY270M, GLY297M, GLY398L, GLY413L, GLY413M, GLY417L, GLY426L, GLY431L, GLY434L, GLY44L, GLY453L, GLY457L, HIS116L, HIS288M, HIS437L, ILE283M, ILE41L, ILE421L, LEU163L, LEU227M, LEU265M, LEU294M, LEU295M, LEU338M, LEU340M, LEU395L, LEU408M, LEU424L, LEU432L, LEU451L, LEU45L, LEU466L, LYS121L, LYS214M, LYS267M, LYS282M, LYS33L, LYS39L, LYS403M, LYS414L, LYS423L, LYS428L, LYS443L, LYS443M, LYS474L, LYS482M, MET118L, MET229M, MET260M, MET303M, MET430L, PHE120L, PHE125L, PHE162L, PHE266M, PHE343M, PHE348M, PHE412M, PHE455L, PHE464L, PRO172M, PRO269M, PRO286M, PRO291M, PRO341M, PRO435L, PRO460L, SER122L, SER161L, SER220M, SER224M, SER253M, SER285M, SER304M, SER339M, SER342M, SER367L, SER397L, SER415L, SER436L, SER465L, SER468L, THR123L, THR124L, THR160L, THR203M, THR221M, THR258M, THR259M, THR290M, THR420L, THR422L, THR42L, THR448L, TRP119L, TRP255M, TRP350M, TRP40L, TRP470L, TYR216M, TYR268M, TYR287M, TYR347M, TYR37L, TYR467L, TYR497L, VAL207M, VAL223M, VAL226M, VAL349M, VAL399L, VAL425L, VAL438L, VAL452L, VAL46L
• M-N: ALA296N, ARG284N, ARG289N, ARG293N, ARG469M, ARG485N, ASP346N, ASP352N, ASP427M, ASP433M, ASP476M, GLN405N, GLU158M, GLU254N, GLU264N, GLU344N, GLU383N, GLU38M, GLU411M, GLU411N, GLU445N, GLU449M, GLY413M, GLY413N, GLY417M, GLY434M, HIS437M, ILE41M, LEU408N, LYS121M, LYS267N, LYS282N, LYS403N, LYS414M, LYS414N, LYS423M, LYS443M, LYS443N, LYS482N, PHE412N, PHE455M, SER339N, SER342N, SER415M, VAL349N, VAL438M
• N-O: ARG284O, ARG289O, ARG293O, ARG469N, ARG485O, ASP346O, ASP352O, ASP427N, ASP433N, ASP476N, GLN405O, GLU158N, GLU254O, GLU264O, GLU344O, GLU383O, GLU38N, GLU411N, GLU411O, GLU445O, GLU449N, GLY413N, GLY413O, GLY417N, GLY434N, HIS437N, ILE41N, LEU408O, LYS121N, LYS267O, LYS282O, LYS403O, LYS414N, LYS414O, LYS423N, LYS443N, LYS443O, LYS482O, MET430N, PHE412O, PHE455N, SER339O, SER342O, SER415N, VAL349O, VAL438N
• N-R: GLU38N, GLU38R, LYS33N, LYS33R
• N-S: ALA143N, ALA316S, ALA58N, ARG55N, ASN59N, GLU141N, GLU151N, GLU274S, LYS267S, LYS33N, PHE244S, SER246S, SER318S, TYR272S
• O-R: ALA143R, ALA316O, ARG55R, ASN59R, GLU274O, LYS267O, LYS33R, PHE244O, THR103R
• P-Q: ALA296Q, ARG284Q, ARG289Q, ARG293Q, ARG469P, ARG485Q, ASP346Q, ASP352Q, ASP427P, ASP433P, ASP476P, GLN405Q, GLU158P, GLU254Q, GLU264Q, GLU344Q, GLU383Q, GLU38P, GLU411P, GLU411Q, GLU445Q, GLU449P, GLY413P, GLY413Q, GLY417P, GLY434P, HIS437P, ILE41P, LEU408Q, LYS121P, LYS267Q, LYS282Q, LYS403Q, LYS414P, LYS414Q, LYS423P, LYS443P, LYS443Q, LYS482Q, PHE412Q, PHE455P, PRO341Q, SER342Q, SER415P, THR42P, VAL349Q, VAL438P
• P-T: ALA296P, ARG284P, ARG289P, ARG293P, ARG469T, ARG485P, ASP346P, ASP352P, ASP427T, ASP433T, ASP476T, GLN405P, GLU158T, GLU254P, GLU264P, GLU344P, GLU383P, GLU38T, GLU411P, GLU411T, GLU445P, GLU449T, GLY413P, GLY413T, GLY417T, GLY434T, HIS437T, ILE41T, LEU408P, LYS121T, LYS267P, LYS282P, LYS403P, LYS414P, LYS414T, LYS423T, LYS443P, LYS443T, LYS482P, PHE412P, PHE455T, PRO341P, SER339P, SER342P, SER415T, TYR467T, VAL349P, VAL438T
• Q-R: ALA296R, ALA456Q, ARG284R, ARG289R, ARG293R, ARG469Q, ARG485R, ASP346R, ASP352R, ASP427Q, ASP433Q, ASP476Q, GLN405R, GLU158Q, GLU254R, GLU264R, GLU344R, GLU383R, GLU38Q, GLU411Q, GLU411R, GLU445R, GLU449Q, GLY413Q, GLY413R, GLY417Q, GLY434Q, HIS437Q, ILE41Q, LEU408R, LYS121Q, LYS267R, LYS282R, LYS403R, LYS414Q, LYS414R, LYS423Q, LYS443Q, LYS443R, LYS482R, PHE412R, PHE455Q, SER342R, SER415Q, THR42Q, VAL349R, VAL438Q
• R-S: ALA296S, ARG284S, ARG289S, ARG293S, ARG469R, ARG485S, ASP346S, ASP352S, ASP427R, ASP433R, ASP476R, GLN405S, GLU158R, GLU254S, GLU264S, GLU344S, GLU383S, GLU38R, GLU411R, GLU411S, GLU445S, GLU449R, GLY413R, GLY413S, GLY417R, GLY434R, HIS437R, ILE41R, LEU408S, LYS121R, LYS267S, LYS282S, LYS403S, LYS414R, LYS414S, LYS423R, LYS443R, LYS443S, LYS482S, PHE412S, PHE455R, PRO341S, SER342S, SER415R, VAL349S, VAL438R
• S-T: ALA296T, ARG284T, ARG289T, ARG293T, ARG469S, ARG485T, ASP346T, ASP352T, ASP427S, ASP433S, ASP476S, GLN405T, GLU158S, GLU254T, GLU264T, GLU344T, GLU383T, GLU38S, GLU411S, GLU411T, GLU445T, GLU449S, GLY413S, GLY413T, GLY417S, GLY434S, HIS437S, ILE41S, LEU408T, LYS121S, LYS267T, LYS282T, LYS403T, LYS414S, LYS414T, LYS423S, LYS443S, LYS443T, LYS482T, PHE412T, PHE455S, SER342T, SER415S, VAL349T, VAL438S