2YHQ

structure of respiratory syncytial virus nucleocapsid protein, p1 crystal form

• Total interactions analyzed: 231
• Total true interactions: 38
• Strongest Interaction:
  • Chains: P-W
  • Int. Res.: 67
  • Norm. En. per Res.: -3.8934
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-69.7627	-113.2992	-588.741	-771.8029	228	24	22	25885	10	68	62
A-C	0.0	0.0	-19.6894	-19.6894	13	0	3	1011	0	1	1
A-I	0.0	0.0	-20.643	-20.643	13	0	3	1011	0	1	1
A-Q	-87.8905	-111.276	-586.778	-785.9445	229	37	21	26163	10	68	60
B-C	-53.6853	-112.2773	-531.708	-697.6706	226	16	21	24490	10	68	58
B-D	0.0	0.0	-23.3528	-23.3528	16	1	3	1137	0	1	1
B-Q	0.0	0.0	-15.7677	-15.7677	12	0	3	895	0	1	1
C-D	-79.2425	-111.3677	-576.759	-767.3692	229	39	20	25791	10	67	61
C-E	0.0	0.0	-17.5677	-17.5677	13	0	3	927	0	1	1
D-E	-42.8234	-109.2418	-517.368	-669.4332	224	16	20	24127	10	68	58
D-F	0.0	0.0	-22.8042	-22.8042	16	2	3	1117	0	1	1
E-F	-85.2476	-113.4858	-548.284	-747.0174	224	29	22	24971	10	67	62
E-G	0.0	0.0	-18.4156	-18.4156	19	3	3	992	0	1	1
F-G	-98.6081	-114.9705	-584.209	-797.7876	229	28	22	25907	10	68	59
F-H	0.0	0.0	-22.7197	-22.7197	15	1	3	1050	0	1	1
F-K	0.0	0.0	-0.4147	-0.4147	6	0	0	96	0	4	1
G-H	-62.5051	-111.1695	-531.893	-705.5676	228	23	21	24461	10	68	59
G-I	0.0	0.0	-22.6614	-22.6614	16	3	3	1117	0	1	1
H-I	-75.9916	-112.9023	-523.204	-712.0979	224	35	20	24495	10	68	61
H-Q	0.0	0.0	-21.1025	-21.1025	14	2	3	1085	0	1	1
H-W	0.0	-2.225	0.0	-2.225	2	0	0	0	0	0	0
I-Q	-76.1034	-116.0305	-565.859	-757.993	227	28	22	25322	10	68	60
J-K	-93.1445	-112.7079	-581.187	-787.0394	230	36	21	25881	10	69	61
J-L	0.0	0.0	-20.3301	-20.3301	15	3	3	1068	0	1	1
J-Z	-57.1013	-110.3804			36
K-L	-68.5885	-110.5499	-528.507	-707.6455	224	20	21	24374	10	68	59
K-M	0.0	0.0	-22.5028	-22.5028	15	1	3	1076	0	1	1
L-M	-90.1871	-110.4576	-543.419	-744.0637	228	35	19	25149	10	68	61
L-N	0.0	0.0	-14.4645	-14.4645	12	0	3	841	0	1	1
M-N	-84.6259	-113.4644	-591.995	-790.0853	227	20	23	25766	10	67	61
M-O	0.0	0.0	-18.2032	-18.2032	13	0	3	955	0	1	1
N-O	-66.5189	-111.0798	-549.367	-726.9657	226	20	21	24870	10	68	58
N-P	0.0	0.0	-22.9787	-22.9787	16	2	3	1038	0	1	1
O-P	-73.3208	-107.9826	-501.027	-682.3304	224	35	18	23922	10	65	60
O-W	0.0	0.0	-15.5907	-15.5907	10	0	3	812	0	1	0
P-W	-67.531	-113.6363	-79.6875	-260.8548	67	3	9	3980	1	6	7
W-Y	-78.4506	-115.6974			41
Y-Z	-76.8053	-115.7787			44

Interface residues

• A-B: ALA173B, ALA229A, ALA244A, ALA250A, ALA264A, ALA264B, ALA275B, ALA279B, ALA291A, ALA298A, ALA2B, ALA309B, ALA349B, ALA372A, ALA70A, ALA86A, ALA86B, ARG150A, ARG234A, ARG238A, ARG259A, ARG27B, ARG73A, ARG84A, ARG84B, ASN13B, ASN249A, ASN269A, ASN269B, ASN305B, ASN306B, ASN343B, ASN360A, ASN360B, ASN364A, ASN364B, ASN37A, ASN45A, ASN9B, ASP10B, ASP155A, ASP15B, ASP175B, ASP221A, ASP221B, ASP31B, ASP369A, ASP39A, ASP78A, ASP85A, ASP85B, GLN16B, GLN230A, GLN255A, GLN26B, GLN278A, GLN278B, GLN283B, GLN292A, GLN316B, GLN356B, GLN41A, GLU148A, GLU211B, GLU214B, GLU240A, GLU280B, GLU282A, GLU282B, GLU286A, GLU286B, GLU289A, GLU297A, GLU297B, GLU359A, GLU373A, GLU374A, GLU77A, GLY174B, GLY227A, GLY235A, GLY236A, GLY241A, GLY245A, GLY252A, GLY261A, GLY273A, GLY273B, GLY295A, GLY296A, GLY299A, GLY30B, GLY361A, GLY75A, GLY87B, HIS216B, HIS218B, HIS225A, HIS225B, HIS274B, HIS319B, HIS43A, HIS89B, ILE220B, ILE228A, ILE242A, ILE25B, ILE270B, ILE303B, ILE363A, ILE363B, ILE80A, ILE82A, ILE82B, LEU12B, LEU161A, LEU171B, LEU17B, LEU18B, LEU246A, LEU258A, LEU263A, LEU272A, LEU272B, LEU294A, LEU304A, LEU304B, LEU311B, LEU312A, LEU314A, LEU331A, LEU346B, LEU357A, LEU357B, LEU368A, LEU370A, LEU375A, LEU3B, LEU74A, LEU83A, LEU83B, LEU8B, LYS14B, LYS215B, LYS22B, LYS265A, LYS265B, LYS268A, LYS268B, LYS293A, LYS308B, LYS358A, LYS42A, LYS5B, LYS7B, LYS81A, LYS81B, LYS91B, MET158A, MET1B, MET248A, MET271B, MET281A, MET281B, MET71A, PHE213B, PHE226A, PHE243A, PHE247A, PHE300A, PHE300B, PHE320A, PRO147A, PRO154A, PRO217B, PRO307B, SER19B, SER20B, SER21B, SER231A, SER232A, SER237A, SER266A, SER276B, SER28B, SER310B, SER32B, SER366A, SER366B, SER4B, SER72A, THR11B, THR233A, THR24B, THR29B, THR371A, THR79A, TYR23B, TYR251A, TYR288A, TYR290A, TYR301B, TYR353B, TYR365A, TYR365B, TYR38A, TYR69A, TYR88B, VAL222A, VAL222B, VAL224A, VAL224B, VAL239A, VAL262A, VAL267A, VAL267B, VAL277A, VAL277B, VAL284A, VAL285A, VAL287A, VAL324A, VAL362A, VAL362B, VAL367A, VAL367B, VAL40A, VAL6B
• A-C: ALA2C, ARG234A, ASN364A, ASP369A, LEU368A, LEU3C, LYS22C, LYS5C, MET1C, SER366A, SER4C, TYR23C, VAL367A
• A-I: ALA2A, ARG234I, ASN364I, ASP369I, LEU368I, LEU3A, LYS22A, LYS5A, MET1A, SER366I, SER4A, TYR23A, VAL367I
• A-Q: ALA173A, ALA229Q, ALA244Q, ALA250Q, ALA264A, ALA264Q, ALA275A, ALA279A, ALA291Q, ALA298Q, ALA2A, ALA309A, ALA349A, ALA372Q, ALA70Q, ALA86A, ALA86Q, ARG150Q, ARG234Q, ARG238Q, ARG259Q, ARG27A, ARG73Q, ARG76Q, ARG84A, ARG84Q, ASN13A, ASN249Q, ASN269A, ASN269Q, ASN305A, ASN306A, ASN360A, ASN360Q, ASN364A, ASN364Q, ASN37Q, ASN45Q, ASN9A, ASP10A, ASP155Q, ASP15A, ASP175A, ASP221A, ASP221Q, ASP31A, ASP369Q, ASP39Q, ASP78Q, ASP85A, ASP85Q, GLN16A, GLN230Q, GLN255Q, GLN26A, GLN278A, GLN278Q, GLN283A, GLN292Q, GLN356A, GLN41Q, GLU148Q, GLU211A, GLU214A, GLU240Q, GLU280A, GLU282A, GLU282Q, GLU286A, GLU286Q, GLU289Q, GLU297A, GLU297Q, GLU359Q, GLU373Q, GLU374Q, GLU77Q, GLY174A, GLY227Q, GLY235Q, GLY236Q, GLY241Q, GLY245Q, GLY252Q, GLY261Q, GLY273A, GLY273Q, GLY295Q, GLY296Q, GLY299Q, GLY30A, GLY361Q, GLY75Q, GLY87A, HIS216A, HIS218A, HIS225A, HIS225Q, HIS274A, HIS319A, HIS43Q, HIS89A, ILE220A, ILE228A, ILE228Q, ILE242Q, ILE25A, ILE270A, ILE303A, ILE363A, ILE363Q, ILE80Q, ILE82A, ILE82Q, LEU12A, LEU161Q, LEU171A, LEU17A, LEU18A, LEU246Q, LEU258Q, LEU263Q, LEU272A, LEU272Q, LEU294Q, LEU304A, LEU304Q, LEU311A, LEU312Q, LEU314Q, LEU331Q, LEU346A, LEU357A, LEU357Q, LEU368Q, LEU370Q, LEU375Q, LEU3A, LEU74Q, LEU83A, LEU83Q, LEU8A, LYS14A, LYS215A, LYS22A, LYS265A, LYS265Q, LYS268A, LYS268Q, LYS293Q, LYS308A, LYS358Q, LYS42Q, LYS5A, LYS7A, LYS81A, LYS81Q, LYS91A, MET158Q, MET1A, MET248Q, MET271A, MET281A, MET281Q, MET71Q, PHE213A, PHE226Q, PHE243Q, PHE247Q, PHE300A, PHE300Q, PHE320Q, PRO147Q, PRO154Q, PRO217A, PRO307A, SER19A, SER20A, SER21A, SER231Q, SER232Q, SER237Q, SER266Q, SER276A, SER28A, SER310A, SER32A, SER366A, SER366Q, SER4A, SER72Q, THR11A, THR233Q, THR24A, THR29A, THR371Q, THR79Q, TRP260Q, TYR23A, TYR251Q, TYR288Q, TYR290Q, TYR301A, TYR353A, TYR365A, TYR365Q, TYR38Q, TYR69Q, TYR88A, VAL222A, VAL222Q, VAL224A, VAL224Q, VAL239Q, VAL262Q, VAL267A, VAL267Q, VAL277A, VAL277Q, VAL284Q, VAL285Q, VAL287Q, VAL324Q, VAL362A, VAL362Q, VAL367A, VAL367Q, VAL40Q, VAL6A
• B-C: ALA173C, ALA229B, ALA244B, ALA250B, ALA264B, ALA264C, ALA275C, ALA279C, ALA291B, ALA298B, ALA2C, ALA309C, ALA349C, ALA372B, ALA70B, ALA86B, ALA86C, ARG150B, ARG234B, ARG238B, ARG259B, ARG27C, ARG73B, ARG84B, ARG84C, ASN13C, ASN249B, ASN269B, ASN269C, ASN305C, ASN306C, ASN343C, ASN360B, ASN360C, ASN364B, ASN364C, ASN37B, ASN45B, ASN9C, ASP10C, ASP155B, ASP15C, ASP175C, ASP221B, ASP221C, ASP31C, ASP369B, ASP39B, ASP78B, ASP85B, ASP85C, GLN16C, GLN230B, GLN255B, GLN26C, GLN278B, GLN278C, GLN283C, GLN292B, GLN316C, GLN356C, GLN41B, GLU148B, GLU211C, GLU214C, GLU240B, GLU280C, GLU282B, GLU282C, GLU286B, GLU286C, GLU289B, GLU297B, GLU297C, GLU359B, GLU373B, GLU374B, GLU77B, GLY174C, GLY227B, GLY235B, GLY236B, GLY241B, GLY245B, GLY252B, GLY261B, GLY273B, GLY273C, GLY295B, GLY296B, GLY299B, GLY30C, GLY361B, GLY75B, GLY87C, HIS216C, HIS218C, HIS225B, HIS225C, HIS274C, HIS319C, HIS43B, HIS89C, ILE220C, ILE228B, ILE242B, ILE25C, ILE270C, ILE303C, ILE363B, ILE363C, ILE80B, ILE82B, ILE82C, LEU12C, LEU171C, LEU17C, LEU18C, LEU246B, LEU258B, LEU263B, LEU272B, LEU272C, LEU294B, LEU304C, LEU311C, LEU312B, LEU314B, LEU331B, LEU346C, LEU357B, LEU357C, LEU368B, LEU370B, LEU375B, LEU3C, LEU74B, LEU83B, LEU83C, LEU8C, LYS14C, LYS215C, LYS22C, LYS265B, LYS265C, LYS268B, LYS268C, LYS293B, LYS308C, LYS358B, LYS42B, LYS5C, LYS7C, LYS81B, LYS81C, LYS91C, MET158B, MET1C, MET248B, MET271C, MET281B, MET281C, MET71B, PHE213C, PHE226B, PHE243B, PHE247B, PHE300B, PHE300C, PHE320B, PRO147B, PRO154B, PRO217C, PRO307C, SER19C, SER20C, SER21C, SER231B, SER232B, SER237B, SER266B, SER276C, SER28C, SER310C, SER32C, SER366B, SER366C, SER4C, SER72B, THR11C, THR233B, THR24C, THR29C, THR371B, THR79B, TYR23C, TYR251B, TYR288B, TYR290B, TYR301C, TYR353C, TYR365B, TYR365C, TYR38B, TYR69B, TYR88C, VAL222B, VAL222C, VAL224B, VAL224C, VAL239B, VAL262B, VAL267B, VAL267C, VAL277B, VAL277C, VAL284B, VAL285B, VAL287B, VAL324B, VAL362B, VAL362C, VAL367B, VAL367C, VAL40B, VAL6C
• B-D: ALA275D, ALA2D, ARG234B, ASN364B, ASP369B, LEU368B, LEU370B, LEU3D, LYS22D, LYS5D, MET1D, SER366B, SER4D, TYR23D, TYR365B, VAL367B
• B-Q: ALA2B, ARG234Q, ASN364Q, ASP369Q, LEU368Q, LEU3B, LYS22B, MET1B, SER366Q, SER4B, TYR23B, VAL367Q
• C-D: ALA173D, ALA229C, ALA244C, ALA250C, ALA264C, ALA264D, ALA275D, ALA279D, ALA291C, ALA298C, ALA2D, ALA309D, ALA349D, ALA372C, ALA70C, ALA86C, ALA86D, ARG150C, ARG234C, ARG238C, ARG259C, ARG27D, ARG73C, ARG76C, ARG84C, ARG84D, ASN13D, ASN249C, ASN269C, ASN269D, ASN305D, ASN306D, ASN360C, ASN360D, ASN364C, ASN364D, ASN37C, ASN45C, ASN9D, ASP10D, ASP155C, ASP15D, ASP175D, ASP221C, ASP221D, ASP31D, ASP369C, ASP39C, ASP78C, ASP85C, ASP85D, GLN16D, GLN230C, GLN255C, GLN26D, GLN278C, GLN278D, GLN283D, GLN292C, GLN356D, GLN41C, GLU148C, GLU211D, GLU214D, GLU240C, GLU280D, GLU282C, GLU282D, GLU286C, GLU286D, GLU289C, GLU297C, GLU297D, GLU359C, GLU373C, GLU374C, GLU77C, GLY174D, GLY227C, GLY235C, GLY236C, GLY241C, GLY245C, GLY252C, GLY261C, GLY273C, GLY273D, GLY295C, GLY296C, GLY299C, GLY30D, GLY361C, GLY75C, GLY87C, GLY87D, HIS216D, HIS218D, HIS225C, HIS225D, HIS274D, HIS319D, HIS43C, HIS89D, ILE220D, ILE228C, ILE228D, ILE242C, ILE25D, ILE270D, ILE303D, ILE363C, ILE363D, ILE80C, ILE82C, ILE82D, LEU12D, LEU161C, LEU171D, LEU17D, LEU18D, LEU246C, LEU258C, LEU263C, LEU272C, LEU272D, LEU294C, LEU304C, LEU304D, LEU311D, LEU312C, LEU314C, LEU331C, LEU346D, LEU357C, LEU357D, LEU368C, LEU370C, LEU375C, LEU3D, LEU74C, LEU83C, LEU83D, LEU8D, LYS14D, LYS215D, LYS22D, LYS265C, LYS265D, LYS268C, LYS268D, LYS293C, LYS308D, LYS358C, LYS42C, LYS5D, LYS7D, LYS81C, LYS81D, LYS91D, MET158C, MET1D, MET248C, MET271D, MET281C, MET281D, MET71C, PHE213D, PHE226C, PHE243C, PHE247C, PHE300C, PHE300D, PHE320C, PRO147C, PRO154C, PRO217D, PRO307D, SER19D, SER20D, SER21D, SER231C, SER232C, SER237C, SER266C, SER276D, SER28D, SER310D, SER32D, SER366C, SER366D, SER4D, SER72C, THR11D, THR233C, THR24D, THR29D, THR371C, THR79C, TYR23D, TYR251C, TYR288C, TYR290C, TYR301D, TYR353D, TYR365C, TYR365D, TYR38C, TYR69C, TYR88D, VAL222C, VAL222D, VAL224C, VAL224D, VAL239C, VAL262C, VAL267C, VAL267D, VAL277C, VAL277D, VAL284C, VAL285C, VAL287C, VAL324C, VAL362C, VAL362D, VAL367C, VAL367D, VAL40C, VAL6D
• C-E: ALA2E, ARG234C, ASN364C, ASP369C, LEU368C, LEU3E, LYS22E, LYS5E, MET1E, SER366C, SER4E, TYR23E, VAL367C
• D-E: ALA173E, ALA229D, ALA244D, ALA250D, ALA264D, ALA264E, ALA275E, ALA279E, ALA291D, ALA298D, ALA2E, ALA309E, ALA349E, ALA372D, ALA70D, ALA86D, ALA86E, ARG150D, ARG234D, ARG238D, ARG259D, ARG27E, ARG73D, ARG84D, ARG84E, ASN13E, ASN249D, ASN269D, ASN269E, ASN305E, ASN306E, ASN360D, ASN360E, ASN364D, ASN364E, ASN37D, ASN45D, ASN9E, ASP10E, ASP155D, ASP15E, ASP175E, ASP221D, ASP221E, ASP31E, ASP369D, ASP39D, ASP78D, ASP85D, ASP85E, GLN16E, GLN230D, GLN255D, GLN26E, GLN278D, GLN278E, GLN283E, GLN292D, GLN316E, GLN356E, GLN41D, GLU148D, GLU211E, GLU214E, GLU240D, GLU280E, GLU282D, GLU282E, GLU286D, GLU286E, GLU289D, GLU297D, GLU297E, GLU359D, GLU373D, GLU374D, GLU77D, GLY174E, GLY227D, GLY235D, GLY236D, GLY241D, GLY245D, GLY252D, GLY261D, GLY273D, GLY273E, GLY295D, GLY296D, GLY299D, GLY30E, GLY361D, GLY75D, GLY87E, HIS216E, HIS218E, HIS225D, HIS225E, HIS274E, HIS319E, HIS43D, HIS89E, ILE220E, ILE228D, ILE242D, ILE25E, ILE270E, ILE303E, ILE363D, ILE363E, ILE80D, ILE82D, ILE82E, LEU12E, LEU171E, LEU17E, LEU18E, LEU246D, LEU258D, LEU263D, LEU272D, LEU272E, LEU294D, LEU304E, LEU311E, LEU312D, LEU314D, LEU331D, LEU346E, LEU357D, LEU357E, LEU368D, LEU370D, LEU375D, LEU3E, LEU74D, LEU83D, LEU83E, LEU8E, LYS14E, LYS215E, LYS22E, LYS265D, LYS265E, LYS268D, LYS268E, LYS293D, LYS308E, LYS358D, LYS42D, LYS5E, LYS7E, LYS81D, LYS81E, LYS91E, MET158D, MET1E, MET248D, MET271E, MET281D, MET281E, MET71D, PHE213E, PHE226D, PHE243D, PHE247D, PHE300D, PHE300E, PHE320D, PRO147D, PRO154D, PRO217E, PRO307E, SER19E, SER20E, SER21E, SER231D, SER232D, SER237D, SER266D, SER276E, SER28E, SER310E, SER32E, SER366D, SER366E, SER4E, SER72D, THR11E, THR233D, THR24E, THR29E, THR371D, THR79D, TYR23E, TYR251D, TYR288D, TYR290D, TYR301E, TYR353E, TYR365D, TYR365E, TYR38D, TYR69D, TYR88E, VAL222E, VAL224D, VAL224E, VAL239D, VAL262D, VAL267D, VAL267E, VAL277D, VAL277E, VAL284D, VAL285D, VAL287D, VAL324D, VAL362D, VAL362E, VAL367D, VAL367E, VAL40D, VAL6E
• D-F: ALA275F, ALA2F, ARG234D, ASN364D, ASP369D, LEU368D, LEU370D, LEU3F, LYS22F, LYS5F, MET1F, SER366D, SER4F, TYR23F, TYR365D, VAL367D
• E-F: ALA173F, ALA229E, ALA244E, ALA250E, ALA264E, ALA264F, ALA275F, ALA279F, ALA291E, ALA298E, ALA2F, ALA309F, ALA349F, ALA372E, ALA70E, ALA86E, ALA86F, ARG150E, ARG234E, ARG238E, ARG259E, ARG27F, ARG73E, ARG84E, ARG84F, ASN13F, ASN249E, ASN269E, ASN269F, ASN305F, ASN306F, ASN360E, ASN360F, ASN364E, ASN364F, ASN37E, ASN45E, ASN9F, ASP10F, ASP155E, ASP15F, ASP175F, ASP221E, ASP221F, ASP31F, ASP369E, ASP39E, ASP78E, ASP85E, ASP85F, GLN16F, GLN230E, GLN255E, GLN26F, GLN278E, GLN278F, GLN283F, GLN292E, GLN356F, GLN41E, GLU148E, GLU211F, GLU214F, GLU240E, GLU280F, GLU282E, GLU282F, GLU286E, GLU286F, GLU289E, GLU297E, GLU297F, GLU359E, GLU373E, GLU374E, GLU77E, GLY174F, GLY227E, GLY235E, GLY236E, GLY241E, GLY245E, GLY252E, GLY261E, GLY273E, GLY273F, GLY295E, GLY296E, GLY299E, GLY30F, GLY361E, GLY75E, GLY87F, HIS216F, HIS218F, HIS225E, HIS225F, HIS274F, HIS319F, HIS43E, HIS89F, ILE220F, ILE228E, ILE242E, ILE25F, ILE270F, ILE303F, ILE363E, ILE363F, ILE80E, ILE82E, ILE82F, LEU12F, LEU171F, LEU17F, LEU18F, LEU246E, LEU258E, LEU263E, LEU272E, LEU272F, LEU294E, LEU304F, LEU311F, LEU312E, LEU314E, LEU331E, LEU346F, LEU357E, LEU357F, LEU368E, LEU370E, LEU375E, LEU3F, LEU74E, LEU83E, LEU83F, LEU8F, LYS14F, LYS215F, LYS22F, LYS265E, LYS265F, LYS268E, LYS268F, LYS293E, LYS308F, LYS358E, LYS42E, LYS5F, LYS7F, LYS81E, LYS81F, LYS91F, MET158E, MET1F, MET248E, MET271F, MET281E, MET281F, MET71E, PHE213F, PHE226E, PHE243E, PHE247E, PHE300E, PHE300F, PHE320E, PRO147E, PRO154E, PRO217F, PRO307F, SER19F, SER20F, SER21F, SER231E, SER232E, SER237E, SER266E, SER276F, SER28F, SER310F, SER32F, SER366E, SER366F, SER4F, SER72E, THR11F, THR233E, THR24F, THR29F, THR371E, THR79E, TYR23F, TYR251E, TYR288E, TYR290E, TYR301F, TYR353F, TYR365E, TYR365F, TYR38E, TYR69E, TYR88F, VAL222E, VAL222F, VAL224E, VAL224F, VAL239E, VAL262E, VAL267E, VAL267F, VAL277E, VAL277F, VAL284E, VAL285E, VAL287E, VAL324E, VAL362E, VAL362F, VAL367E, VAL367F, VAL40E, VAL6F
• E-G: ALA275G, ALA2G, ALA372E, ARG234E, ASN364E, ASP369E, GLN278G, LEU368E, LEU370E, LEU3G, LYS22G, LYS5G, MET1G, SER366E, SER4G, THR371E, TYR23G, TYR365E, VAL367E
• F-G: ALA173G, ALA229F, ALA244F, ALA250F, ALA264F, ALA264G, ALA275G, ALA279G, ALA291F, ALA298F, ALA2G, ALA309G, ALA349G, ALA372F, ALA70F, ALA86F, ALA86G, ARG150F, ARG234F, ARG238F, ARG259F, ARG27G, ARG73F, ARG84F, ARG84G, ASN13G, ASN249F, ASN269F, ASN269G, ASN305G, ASN306G, ASN343G, ASN360F, ASN360G, ASN364F, ASN364G, ASN37F, ASN45F, ASN9G, ASP10G, ASP155F, ASP15G, ASP175G, ASP221F, ASP221G, ASP31G, ASP369F, ASP39F, ASP78F, ASP85F, ASP85G, GLN16G, GLN230F, GLN255F, GLN26G, GLN278F, GLN278G, GLN283G, GLN292F, GLN356G, GLN41F, GLU148F, GLU211G, GLU214G, GLU240F, GLU280G, GLU282F, GLU282G, GLU286F, GLU286G, GLU289F, GLU297F, GLU297G, GLU359F, GLU373F, GLU374F, GLU77F, GLY174G, GLY227F, GLY235F, GLY236F, GLY241F, GLY245F, GLY252F, GLY261F, GLY273F, GLY273G, GLY295F, GLY296F, GLY299F, GLY30G, GLY361F, GLY75F, GLY87G, HIS216G, HIS218G, HIS225F, HIS225G, HIS274G, HIS319G, HIS43F, HIS89G, ILE220G, ILE228F, ILE242F, ILE25G, ILE270G, ILE303G, ILE363F, ILE363G, ILE80F, ILE80G, ILE82F, ILE82G, LEU12G, LEU161F, LEU171G, LEU17G, LEU18G, LEU246F, LEU258F, LEU263F, LEU272F, LEU272G, LEU294F, LEU304F, LEU304G, LEU311G, LEU312F, LEU314F, LEU331F, LEU346G, LEU357F, LEU357G, LEU368F, LEU370F, LEU375F, LEU3G, LEU74F, LEU83F, LEU83G, LEU8G, LYS14G, LYS215G, LYS22G, LYS265F, LYS265G, LYS268F, LYS268G, LYS293F, LYS308G, LYS358F, LYS42F, LYS5G, LYS7G, LYS81F, LYS81G, LYS91G, MET158F, MET1G, MET248F, MET271G, MET281F, MET281G, MET71F, PHE213G, PHE226F, PHE243F, PHE247F, PHE300F, PHE300G, PHE320F, PRO147F, PRO154F, PRO217G, PRO307G, SER19G, SER20G, SER21G, SER231F, SER232F, SER237F, SER266F, SER276G, SER28G, SER310G, SER32G, SER366F, SER366G, SER4G, SER72F, THR11G, THR233F, THR24G, THR29G, THR371F, THR79F, TYR23G, TYR251F, TYR288F, TYR290F, TYR301G, TYR353G, TYR365F, TYR365G, TYR38F, TYR69F, TYR88G, VAL222F, VAL222G, VAL224F, VAL224G, VAL239F, VAL262F, VAL267F, VAL267G, VAL277F, VAL277G, VAL284F, VAL285F, VAL287F, VAL323G, VAL324F, VAL362F, VAL362G, VAL367F, VAL367G, VAL40F, VAL6G
• F-H: ALA2H, ARG234F, ASN364F, ASP369F, LEU368F, LEU370F, LEU3H, LYS22H, LYS5H, MET1H, SER366F, SER4H, TYR23H, TYR365F, VAL367F
• F-K: ARG101F, ASN360K, GLN356K, GLU355K, GLU359K, LYS110F
• G-H: ALA173H, ALA229G, ALA244G, ALA250G, ALA264G, ALA264H, ALA275H, ALA279H, ALA291G, ALA298G, ALA2H, ALA309H, ALA349H, ALA372G, ALA70G, ALA86G, ALA86H, ARG150G, ARG234G, ARG238G, ARG259G, ARG27H, ARG73G, ARG84G, ARG84H, ASN13H, ASN249G, ASN269G, ASN269H, ASN305H, ASN306H, ASN360G, ASN360H, ASN364G, ASN364H, ASN37G, ASN45G, ASN9H, ASP10H, ASP155G, ASP15H, ASP175H, ASP221G, ASP221H, ASP31H, ASP369G, ASP39G, ASP78G, ASP85G, ASP85H, GLN16H, GLN230G, GLN255G, GLN26H, GLN278G, GLN278H, GLN283H, GLN292G, GLN316H, GLN356H, GLN41G, GLU148G, GLU211H, GLU214H, GLU240G, GLU280H, GLU282G, GLU282H, GLU286G, GLU286H, GLU289G, GLU297G, GLU297H, GLU359G, GLU373G, GLU374G, GLU77G, GLY174H, GLY227G, GLY235G, GLY236G, GLY241G, GLY245G, GLY252G, GLY261G, GLY273G, GLY273H, GLY295G, GLY296G, GLY299G, GLY30H, GLY361G, GLY75G, GLY87H, HIS216H, HIS218H, HIS225G, HIS225H, HIS274H, HIS319H, HIS43G, HIS89H, ILE220H, ILE228G, ILE242G, ILE25H, ILE270G, ILE270H, ILE303H, ILE363G, ILE363H, ILE80G, ILE82G, ILE82H, LEU12H, LEU171H, LEU17H, LEU18H, LEU246G, LEU258G, LEU263G, LEU272G, LEU272H, LEU294G, LEU304H, LEU311H, LEU312G, LEU314G, LEU331G, LEU346H, LEU357G, LEU357H, LEU368G, LEU370G, LEU375G, LEU3H, LEU74G, LEU83G, LEU83H, LEU8H, LYS14H, LYS215H, LYS22H, LYS265G, LYS265H, LYS268G, LYS268H, LYS293G, LYS308H, LYS358G, LYS42G, LYS5H, LYS7H, LYS81G, LYS81H, LYS91H, MET158G, MET1H, MET248G, MET271H, MET281G, MET281H, MET71G, PHE213H, PHE226G, PHE243G, PHE247G, PHE300G, PHE300H, PHE320G, PRO147G, PRO154G, PRO217H, PRO307H, SER153G, SER19H, SER20H, SER21H, SER231G, SER232G, SER237G, SER266G, SER276H, SER28H, SER310H, SER32H, SER366G, SER366H, SER4H, SER72G, THR11H, THR233G, THR24H, THR29H, THR371G, THR79G, TRP260G, TYR23H, TYR251G, TYR288G, TYR290G, TYR301H, TYR353H, TYR365G, TYR365H, TYR38G, TYR69G, TYR88H, VAL222G, VAL222H, VAL224G, VAL224H, VAL239G, VAL262G, VAL267G, VAL267H, VAL277G, VAL277H, VAL284G, VAL285G, VAL287G, VAL324G, VAL362G, VAL362H, VAL367G, VAL367H, VAL40G, VAL6H
• G-I: ALA275I, ALA2I, ARG234G, ASN364G, ASP369G, LEU368G, LEU370G, LEU3I, LYS22I, LYS5I, MET1I, SER366G, SER4I, TYR23I, TYR365G, VAL367G
• H-I: ALA173I, ALA229H, ALA244H, ALA250H, ALA264H, ALA264I, ALA275I, ALA279I, ALA291H, ALA298H, ALA2I, ALA309I, ALA349I, ALA372H, ALA70H, ALA86H, ALA86I, ARG150H, ARG234H, ARG238H, ARG259H, ARG27I, ARG73H, ARG76H, ARG84H, ARG84I, ASN13I, ASN249H, ASN269H, ASN269I, ASN305I, ASN306I, ASN360H, ASN360I, ASN364H, ASN364I, ASN37H, ASN45H, ASN9I, ASP10I, ASP155H, ASP15I, ASP175I, ASP221H, ASP221I, ASP31I, ASP369H, ASP39H, ASP78H, ASP85H, ASP85I, GLN16I, GLN230H, GLN255H, GLN26I, GLN278H, GLN278I, GLN283I, GLN292H, GLN356I, GLN41H, GLU148H, GLU211I, GLU214I, GLU240H, GLU280I, GLU282H, GLU282I, GLU286H, GLU286I, GLU289H, GLU297H, GLU297I, GLU359H, GLU373H, GLU374H, GLU77H, GLY174I, GLY227H, GLY235H, GLY236H, GLY241H, GLY245H, GLY252H, GLY261H, GLY273H, GLY273I, GLY295H, GLY296H, GLY299H, GLY30I, GLY361H, GLY75H, GLY87I, HIS216I, HIS218I, HIS225H, HIS225I, HIS274I, HIS319I, HIS43H, HIS89I, ILE220I, ILE228H, ILE242H, ILE25I, ILE270I, ILE303I, ILE363H, ILE363I, ILE80H, ILE82H, ILE82I, LEU12I, LEU171I, LEU17I, LEU18I, LEU246H, LEU258H, LEU263H, LEU272H, LEU272I, LEU294H, LEU304I, LEU311I, LEU312H, LEU314H, LEU331H, LEU346I, LEU357H, LEU357I, LEU368H, LEU370H, LEU375H, LEU3I, LEU74H, LEU83H, LEU83I, LEU8I, LYS14I, LYS215I, LYS22I, LYS265H, LYS265I, LYS268H, LYS268I, LYS293H, LYS308I, LYS358H, LYS42H, LYS5I, LYS7I, LYS81H, LYS81I, LYS91I, MET158H, MET1I, MET248H, MET271I, MET281H, MET281I, MET71H, PHE213I, PHE226H, PHE243H, PHE247H, PHE300H, PHE300I, PHE320H, PRO147H, PRO154H, PRO217I, PRO307I, SER153H, SER19I, SER20I, SER21I, SER231H, SER232H, SER237H, SER266H, SER276I, SER28I, SER310I, SER32I, SER366H, SER366I, SER4I, SER72H, THR11I, THR233H, THR24I, THR29I, THR371H, THR79H, TYR23I, TYR251H, TYR288H, TYR290H, TYR301I, TYR353I, TYR365H, TYR365I, TYR38H, TYR69H, TYR88I, VAL222I, VAL224H, VAL224I, VAL239H, VAL262H, VAL267H, VAL267I, VAL277H, VAL277I, VAL284H, VAL285H, VAL287H, VAL362H, VAL362I, VAL367H, VAL367I, VAL40H, VAL6I
• H-Q: ALA2Q, ARG234H, ASN364H, ASP369H, LEU368H, LEU370H, LEU3Q, LYS22Q, LYS5Q, MET1Q, SER366H, SER4Q, TYR23Q, VAL367H
• H-W: ARG101H, GLU374W
• I-Q: ALA173Q, ALA229I, ALA244I, ALA250I, ALA264I, ALA264Q, ALA275Q, ALA279Q, ALA291I, ALA298I, ALA2Q, ALA309Q, ALA349Q, ALA372I, ALA70I, ALA86I, ALA86Q, ARG234I, ARG238I, ARG259I, ARG27Q, ARG73I, ARG84I, ARG84Q, ASN13Q, ASN249I, ASN269I, ASN269Q, ASN305Q, ASN306Q, ASN360I, ASN360Q, ASN364I, ASN364Q, ASN37I, ASN45I, ASN9Q, ASP10Q, ASP155I, ASP15Q, ASP175Q, ASP221I, ASP221Q, ASP31Q, ASP369I, ASP39I, ASP78I, ASP85I, ASP85Q, GLN16Q, GLN230I, GLN255I, GLN26Q, GLN278I, GLN278Q, GLN283Q, GLN292I, GLN316Q, GLN356Q, GLN41I, GLU148I, GLU211Q, GLU214Q, GLU240I, GLU280Q, GLU282I, GLU282Q, GLU286I, GLU286Q, GLU289I, GLU297I, GLU297Q, GLU359I, GLU373I, GLU374I, GLU77I, GLY174Q, GLY227I, GLY235I, GLY236I, GLY241I, GLY245I, GLY252I, GLY261I, GLY273I, GLY273Q, GLY295I, GLY296I, GLY299I, GLY30Q, GLY361I, GLY75I, GLY87Q, HIS216Q, HIS218Q, HIS225I, HIS225Q, HIS274Q, HIS319Q, HIS43I, HIS89Q, ILE220Q, ILE228I, ILE228Q, ILE242I, ILE25Q, ILE270Q, ILE303Q, ILE363I, ILE363Q, ILE80I, ILE82I, ILE82Q, LEU12Q, LEU171Q, LEU17Q, LEU18Q, LEU246I, LEU258I, LEU263I, LEU272I, LEU272Q, LEU294I, LEU304I, LEU304Q, LEU311Q, LEU312I, LEU314I, LEU331I, LEU346Q, LEU357I, LEU357Q, LEU368I, LEU370I, LEU375I, LEU3Q, LEU74I, LEU83I, LEU83Q, LEU8Q, LYS14Q, LYS215Q, LYS22Q, LYS265I, LYS265Q, LYS268I, LYS268Q, LYS293I, LYS308Q, LYS358I, LYS42I, LYS5Q, LYS7Q, LYS81I, LYS81Q, LYS91Q, MET158I, MET1Q, MET248I, MET271Q, MET281I, MET281Q, MET71I, PHE213Q, PHE226I, PHE243I, PHE247I, PHE300I, PHE300Q, PHE320I, PRO147I, PRO154I, PRO217Q, PRO307Q, SER19Q, SER20Q, SER21Q, SER231I, SER232I, SER237I, SER266I, SER276Q, SER28Q, SER310Q, SER32Q, SER366I, SER366Q, SER4Q, SER72I, THR11Q, THR233I, THR24Q, THR29Q, THR371I, THR79I, TRP260I, TYR23Q, TYR251I, TYR288I, TYR290I, TYR301Q, TYR353Q, TYR365I, TYR365Q, TYR38I, TYR69I, TYR88Q, VAL222I, VAL222Q, VAL224I, VAL224Q, VAL239I, VAL262I, VAL267I, VAL267Q, VAL277I, VAL277Q, VAL284I, VAL285I, VAL287I, VAL324I, VAL362I, VAL362Q, VAL367I, VAL367Q, VAL40I, VAL6Q
• J-K: ALA173K, ALA229J, ALA244J, ALA250J, ALA264J, ALA264K, ALA275K, ALA279K, ALA291J, ALA298J, ALA2K, ALA309K, ALA349K, ALA372J, ALA70J, ALA86J, ALA86K, ARG150J, ARG234J, ARG238J, ARG259J, ARG27K, ARG73J, ARG76J, ARG84J, ARG84K, ASN13K, ASN249J, ASN269J, ASN269K, ASN305K, ASN306K, ASN360J, ASN360K, ASN364J, ASN364K, ASN37J, ASN45J, ASN9K, ASP10K, ASP155J, ASP15K, ASP175K, ASP221J, ASP221K, ASP31K, ASP369J, ASP39J, ASP78J, ASP85J, ASP85K, GLN16K, GLN230J, GLN255J, GLN26K, GLN278J, GLN278K, GLN283K, GLN292J, GLN356K, GLN41J, GLU148J, GLU211K, GLU214K, GLU240J, GLU280K, GLU282J, GLU282K, GLU286J, GLU286K, GLU289J, GLU297J, GLU297K, GLU359J, GLU373J, GLU374J, GLU77J, GLY174K, GLY227J, GLY235J, GLY236J, GLY241J, GLY245J, GLY252J, GLY261J, GLY273J, GLY273K, GLY295J, GLY296J, GLY299J, GLY30K, GLY361J, GLY75J, GLY87J, GLY87K, HIS216K, HIS218K, HIS225J, HIS225K, HIS274K, HIS319K, HIS43J, HIS89K, ILE220K, ILE228J, ILE228K, ILE242J, ILE25K, ILE270K, ILE303K, ILE363J, ILE363K, ILE80J, ILE82J, ILE82K, LEU12K, LEU161J, LEU171K, LEU17K, LEU18K, LEU246J, LEU258J, LEU263J, LEU272J, LEU272K, LEU294J, LEU304J, LEU304K, LEU311K, LEU312J, LEU314J, LEU331J, LEU346K, LEU357J, LEU357K, LEU368J, LEU370J, LEU375J, LEU3K, LEU74J, LEU83J, LEU83K, LEU8K, LYS14K, LYS215K, LYS22K, LYS265J, LYS265K, LYS268J, LYS268K, LYS293J, LYS308K, LYS358J, LYS42J, LYS5K, LYS7K, LYS81J, LYS81K, LYS91K, MET158J, MET1K, MET248J, MET271K, MET281J, MET281K, MET71J, PHE213K, PHE226J, PHE243J, PHE247J, PHE300J, PHE300K, PHE320J, PRO147J, PRO154J, PRO217K, PRO307K, SER19K, SER20K, SER21K, SER231J, SER232J, SER237J, SER266J, SER276K, SER28K, SER310K, SER32K, SER366J, SER366K, SER4K, SER72J, THR11K, THR233J, THR24K, THR29K, THR371J, THR79J, TRP260J, TYR23K, TYR251J, TYR288J, TYR290J, TYR301K, TYR353K, TYR365J, TYR365K, TYR38J, TYR69J, TYR88K, VAL222J, VAL222K, VAL224J, VAL224K, VAL239J, VAL262J, VAL267J, VAL267K, VAL277J, VAL277K, VAL284J, VAL285J, VAL287J, VAL324J, VAL362J, VAL362K, VAL367J, VAL367K, VAL40J, VAL6K
• J-L: ALA2L, ARG234J, ASN364J, ASP369J, LEU368J, LEU370J, LEU3L, LYS22L, LYS5L, MET1L, SER366J, SER4L, TYR23L, TYR365J, VAL367J
• J-Z: ARG234Z, ARG238Z, ARG259Z, ARG27J, ARG73Z, ASN364Z, ASP10J, ASP175J, ASP221J, ASP31J, ASP369Z, ASP39Z, ASP85J, ASP85Z, GLU148Z, GLU214J, GLU240Z, GLU282J, GLU289Z, GLU297J, GLU373Z, GLY273J, GLY30J, HIS225J, HIS225Z, HIS89J, ILE82J, LYS22J, LYS265Z, LYS268J, LYS42Z, LYS5J, LYS7J, LYS81Z, THR233Z, TYR23J
• K-L: ALA173L, ALA229K, ALA244K, ALA250K, ALA264K, ALA264L, ALA275L, ALA279L, ALA291K, ALA298K, ALA2L, ALA309L, ALA349L, ALA372K, ALA70K, ALA86K, ALA86L, ARG150K, ARG234K, ARG238K, ARG259K, ARG27L, ARG73K, ARG84K, ARG84L, ASN13L, ASN249K, ASN269K, ASN269L, ASN305L, ASN306L, ASN360K, ASN360L, ASN364K, ASN364L, ASN37K, ASN45K, ASN9L, ASP10L, ASP155K, ASP15L, ASP175L, ASP221K, ASP221L, ASP31L, ASP369K, ASP39K, ASP78K, ASP85K, ASP85L, GLN16L, GLN230K, GLN255K, GLN26L, GLN278K, GLN278L, GLN283L, GLN292K, GLN316L, GLN356L, GLN41K, GLU148K, GLU211L, GLU214L, GLU240K, GLU280L, GLU282K, GLU282L, GLU286K, GLU286L, GLU289K, GLU297K, GLU297L, GLU359K, GLU373K, GLU374K, GLU77K, GLY174L, GLY227K, GLY235K, GLY236K, GLY241K, GLY245K, GLY252K, GLY261K, GLY273K, GLY273L, GLY295K, GLY296K, GLY299K, GLY30L, GLY361K, GLY75K, GLY87L, HIS216L, HIS218L, HIS225K, HIS225L, HIS274L, HIS319L, HIS43K, HIS89L, ILE220L, ILE228K, ILE242K, ILE25L, ILE270L, ILE303L, ILE363K, ILE363L, ILE80K, ILE82K, ILE82L, LEU12L, LEU171L, LEU17L, LEU18L, LEU246K, LEU258K, LEU263K, LEU272K, LEU272L, LEU294K, LEU304L, LEU311L, LEU312K, LEU314K, LEU331K, LEU346L, LEU357K, LEU357L, LEU368K, LEU370K, LEU375K, LEU3L, LEU74K, LEU83K, LEU83L, LEU8L, LYS14L, LYS215L, LYS22L, LYS265K, LYS265L, LYS268K, LYS268L, LYS293K, LYS308L, LYS358K, LYS42K, LYS5L, LYS7L, LYS81K, LYS81L, LYS91L, MET158K, MET1L, MET248K, MET271L, MET281K, MET281L, MET71K, PHE213L, PHE226K, PHE243K, PHE247K, PHE300K, PHE300L, PHE320K, PRO147K, PRO154K, PRO217L, PRO307L, SER19L, SER20L, SER21L, SER231K, SER232K, SER237K, SER266K, SER276L, SER28L, SER310L, SER32L, SER366K, SER366L, SER4L, SER72K, THR11L, THR233K, THR24L, THR29L, THR371K, THR79K, TYR23L, TYR251K, TYR288K, TYR290K, TYR301L, TYR353L, TYR365K, TYR365L, TYR38K, TYR69K, TYR88L, VAL222L, VAL224K, VAL224L, VAL239K, VAL262K, VAL267K, VAL267L, VAL277K, VAL277L, VAL284K, VAL285K, VAL287K, VAL324K, VAL362K, VAL362L, VAL367K, VAL367L, VAL40K, VAL6L
• K-M: ALA2M, ARG234K, ASN364K, ASP369K, LEU368K, LEU370K, LEU3M, LYS22M, LYS5M, MET1M, SER366K, SER4M, TYR23M, TYR365K, VAL367K
• L-M: ALA173M, ALA229L, ALA244L, ALA250L, ALA264L, ALA264M, ALA275M, ALA279M, ALA291L, ALA298L, ALA2M, ALA309M, ALA349M, ALA372L, ALA70L, ALA86L, ALA86M, ARG150L, ARG234L, ARG238L, ARG259L, ARG27M, ARG73L, ARG76L, ARG84L, ARG84M, ASN13M, ASN249L, ASN269L, ASN269M, ASN305M, ASN306M, ASN360L, ASN360M, ASN364L, ASN364M, ASN37L, ASN45L, ASN9M, ASP10M, ASP155L, ASP15M, ASP175M, ASP221L, ASP221M, ASP31M, ASP369L, ASP39L, ASP78L, ASP85L, ASP85M, GLN16M, GLN230L, GLN255L, GLN26M, GLN278L, GLN278M, GLN283M, GLN292L, GLN356M, GLN41L, GLU148L, GLU211M, GLU214M, GLU240L, GLU280M, GLU282L, GLU282M, GLU286L, GLU286M, GLU289L, GLU297L, GLU297M, GLU359L, GLU373L, GLU374L, GLU77L, GLY174M, GLY227L, GLY235L, GLY236L, GLY241L, GLY245L, GLY252L, GLY261L, GLY273L, GLY273M, GLY295L, GLY296L, GLY299L, GLY30M, GLY361L, GLY75L, GLY87M, HIS216M, HIS218M, HIS225L, HIS225M, HIS274M, HIS319M, HIS43L, HIS89M, ILE220M, ILE228L, ILE228M, ILE242L, ILE25M, ILE270M, ILE303M, ILE363L, ILE363M, ILE80L, ILE82L, ILE82M, LEU12M, LEU161L, LEU171M, LEU17M, LEU18M, LEU246L, LEU258L, LEU263L, LEU272L, LEU272M, LEU294L, LEU304L, LEU304M, LEU311M, LEU312L, LEU314L, LEU331L, LEU346M, LEU357L, LEU357M, LEU368L, LEU370L, LEU375L, LEU3M, LEU74L, LEU83L, LEU83M, LEU8M, LYS14M, LYS215M, LYS22M, LYS265L, LYS265M, LYS268L, LYS268M, LYS293L, LYS308M, LYS358L, LYS42L, LYS5M, LYS7M, LYS81L, LYS81M, LYS91M, MET158L, MET1M, MET248L, MET271M, MET281L, MET281M, MET71L, PHE213M, PHE226L, PHE243L, PHE247L, PHE300L, PHE300M, PHE320L, PRO147L, PRO154L, PRO217M, PRO307M, SER19M, SER20M, SER21M, SER231L, SER232L, SER237L, SER266L, SER276M, SER28M, SER310M, SER32M, SER366L, SER366M, SER4M, SER72L, THR11M, THR233L, THR24M, THR29M, THR371L, THR79L, TYR23M, TYR251L, TYR288L, TYR290L, TYR301M, TYR353M, TYR365L, TYR365M, TYR38L, TYR69L, TYR88M, VAL222L, VAL222M, VAL224L, VAL224M, VAL239L, VAL262L, VAL267L, VAL267M, VAL277L, VAL277M, VAL284L, VAL285L, VAL287L, VAL324L, VAL362L, VAL362M, VAL367L, VAL367M, VAL40L, VAL6M
• L-N: ALA2N, ARG234L, ASN364L, ASP369L, LEU368L, LEU3N, LYS22N, MET1N, SER366L, SER4N, TYR23N, VAL367L
• M-N: ALA173N, ALA229M, ALA244M, ALA250M, ALA264M, ALA264N, ALA275N, ALA279N, ALA291M, ALA298M, ALA2N, ALA309N, ALA349N, ALA372M, ALA70M, ALA86M, ALA86N, ARG150M, ARG234M, ARG238M, ARG259M, ARG27N, ARG73M, ARG84M, ARG84N, ASN13N, ASN249M, ASN269M, ASN269N, ASN305N, ASN306N, ASN360M, ASN360N, ASN364M, ASN364N, ASN37M, ASN45M, ASN9N, ASP10N, ASP155M, ASP15N, ASP175N, ASP221M, ASP221N, ASP31N, ASP369M, ASP39M, ASP78M, ASP85M, ASP85N, GLN16N, GLN230M, GLN255M, GLN26N, GLN278M, GLN278N, GLN283N, GLN292M, GLN356N, GLN41M, GLU148M, GLU211N, GLU214N, GLU240M, GLU280N, GLU282M, GLU282N, GLU286M, GLU286N, GLU289M, GLU297M, GLU297N, GLU359M, GLU373M, GLU374M, GLU77M, GLY174N, GLY227M, GLY235M, GLY236M, GLY241M, GLY245M, GLY252M, GLY261M, GLY273M, GLY273N, GLY295M, GLY296M, GLY299M, GLY30N, GLY361M, GLY75M, GLY87N, HIS216N, HIS218N, HIS225M, HIS225N, HIS274N, HIS319N, HIS43M, HIS89N, ILE220N, ILE228M, ILE228N, ILE242M, ILE25N, ILE270N, ILE303N, ILE363M, ILE363N, ILE80M, ILE82M, ILE82N, LEU12N, LEU161M, LEU171N, LEU17N, LEU18N, LEU246M, LEU258M, LEU263M, LEU272M, LEU272N, LEU294M, LEU304M, LEU304N, LEU311N, LEU312M, LEU314M, LEU331M, LEU346N, LEU357M, LEU357N, LEU368M, LEU370M, LEU375M, LEU3N, LEU74M, LEU83M, LEU83N, LEU8N, LYS14N, LYS215N, LYS22N, LYS265M, LYS265N, LYS268M, LYS268N, LYS293M, LYS308N, LYS358M, LYS42M, LYS5N, LYS7N, LYS81M, LYS81N, LYS91N, MET158M, MET1N, MET248M, MET271N, MET281M, MET281N, MET71M, PHE213N, PHE226M, PHE243M, PHE247M, PHE300M, PHE300N, PHE320M, PRO147M, PRO154M, PRO217N, PRO307N, SER19N, SER20N, SER21N, SER231M, SER232M, SER237M, SER266M, SER276N, SER28N, SER310N, SER32N, SER366M, SER366N, SER4N, SER72M, THR11N, THR233M, THR24N, THR29N, THR371M, THR79M, TYR23N, TYR251M, TYR288M, TYR290M, TYR301N, TYR353N, TYR365M, TYR365N, TYR38M, TYR69M, TYR88N, VAL222M, VAL222N, VAL224M, VAL224N, VAL239M, VAL262M, VAL267M, VAL267N, VAL277M, VAL277N, VAL284M, VAL285M, VAL287M, VAL324M, VAL362M, VAL362N, VAL367M, VAL367N, VAL40M, VAL6N
• M-O: ALA2O, ARG234M, ASN364M, ASP369M, LEU368M, LEU3O, LYS22O, LYS5O, MET1O, SER366M, SER4O, TYR23O, VAL367M
• N-O: ALA173O, ALA229N, ALA244N, ALA250N, ALA264N, ALA264O, ALA275O, ALA279O, ALA291N, ALA298N, ALA2O, ALA309O, ALA349O, ALA372N, ALA70N, ALA86N, ALA86O, ARG150N, ARG234N, ARG238N, ARG259N, ARG27O, ARG73N, ARG84N, ARG84O, ASN13O, ASN249N, ASN269N, ASN269O, ASN305O, ASN306O, ASN343O, ASN360N, ASN360O, ASN364N, ASN364O, ASN37N, ASN45N, ASN9O, ASP10O, ASP155N, ASP15O, ASP175O, ASP221N, ASP221O, ASP31O, ASP369N, ASP39N, ASP78N, ASP85N, ASP85O, GLN16O, GLN230N, GLN255N, GLN26O, GLN278N, GLN278O, GLN283O, GLN292N, GLN316O, GLN356O, GLN41N, GLU148N, GLU211O, GLU214O, GLU240N, GLU280O, GLU282N, GLU282O, GLU286N, GLU286O, GLU289N, GLU297N, GLU297O, GLU359N, GLU373N, GLU374N, GLU77N, GLY174O, GLY227N, GLY235N, GLY236N, GLY241N, GLY245N, GLY252N, GLY261N, GLY273N, GLY273O, GLY295N, GLY296N, GLY299N, GLY30O, GLY361N, GLY75N, GLY87O, HIS216O, HIS218O, HIS225N, HIS225O, HIS274O, HIS319O, HIS43N, HIS89O, ILE220O, ILE228N, ILE242N, ILE25O, ILE270O, ILE303O, ILE363N, ILE363O, ILE80N, ILE82N, ILE82O, LEU12O, LEU171O, LEU17O, LEU18O, LEU246N, LEU258N, LEU263N, LEU272N, LEU272O, LEU294N, LEU304O, LEU311O, LEU312N, LEU314N, LEU331N, LEU346O, LEU357N, LEU357O, LEU368N, LEU370N, LEU375N, LEU3O, LEU74N, LEU83N, LEU83O, LEU8O, LYS14O, LYS215O, LYS22O, LYS265N, LYS265O, LYS268N, LYS268O, LYS293N, LYS308O, LYS358N, LYS42N, LYS5O, LYS7O, LYS81N, LYS81O, LYS91O, MET158N, MET1O, MET248N, MET271O, MET281N, MET281O, MET71N, PHE213O, PHE226N, PHE243N, PHE247N, PHE300N, PHE300O, PHE320N, PRO147N, PRO154N, PRO217O, PRO307O, SER19O, SER20O, SER21O, SER231N, SER232N, SER237N, SER266N, SER276O, SER28O, SER310O, SER32O, SER366N, SER366O, SER4O, SER72N, THR11O, THR233N, THR24O, THR29O, THR371N, THR79N, TYR23O, TYR251N, TYR288N, TYR290N, TYR301O, TYR353O, TYR365N, TYR365O, TYR38N, TYR69N, TYR88O, VAL222N, VAL222O, VAL224N, VAL224O, VAL239N, VAL262N, VAL267N, VAL267O, VAL277N, VAL277O, VAL284N, VAL285N, VAL287N, VAL324N, VAL362N, VAL362O, VAL367N, VAL367O, VAL40N, VAL6O
• N-P: ALA275P, ALA2P, ARG234N, ASN364N, ASP369N, LEU368N, LEU370N, LEU3P, LYS22P, LYS5P, MET1P, SER366N, SER4P, TYR23P, TYR365N, VAL367N
• O-P: ALA173P, ALA229O, ALA244O, ALA250O, ALA264O, ALA264P, ALA275P, ALA279P, ALA291O, ALA298O, ALA2P, ALA309P, ALA349P, ALA372O, ALA70O, ALA86O, ALA86P, ARG150O, ARG234O, ARG238O, ARG259O, ARG27P, ARG73O, ARG76O, ARG84O, ARG84P, ASN13P, ASN249O, ASN269O, ASN269P, ASN305P, ASN306P, ASN360O, ASN360P, ASN364O, ASN364P, ASN37O, ASN45O, ASN9P, ASP10P, ASP155O, ASP15P, ASP175P, ASP221O, ASP221P, ASP31P, ASP369O, ASP39O, ASP78O, ASP85O, ASP85P, GLN16P, GLN230O, GLN255O, GLN26P, GLN278O, GLN278P, GLN283P, GLN292O, GLN356P, GLN41O, GLU148O, GLU211P, GLU214P, GLU240O, GLU280P, GLU282O, GLU282P, GLU286O, GLU286P, GLU289O, GLU297O, GLU297P, GLU359O, GLU373O, GLU374O, GLU77O, GLY174P, GLY227O, GLY235O, GLY236O, GLY241O, GLY245O, GLY252O, GLY261O, GLY273O, GLY273P, GLY295O, GLY296O, GLY299O, GLY30P, GLY361O, GLY75O, GLY87P, HIS216P, HIS218P, HIS225O, HIS225P, HIS274P, HIS319P, HIS43O, HIS89P, ILE220P, ILE228O, ILE242O, ILE25P, ILE270P, ILE303P, ILE363O, ILE363P, ILE80O, ILE82O, ILE82P, LEU12P, LEU171P, LEU17P, LEU18P, LEU246O, LEU258O, LEU263O, LEU272O, LEU272P, LEU294O, LEU304P, LEU311P, LEU312O, LEU314O, LEU331O, LEU346P, LEU357O, LEU357P, LEU368O, LEU370O, LEU375O, LEU3P, LEU74O, LEU83O, LEU83P, LEU8P, LYS14P, LYS215P, LYS22P, LYS265O, LYS265P, LYS268O, LYS268P, LYS293O, LYS308P, LYS358O, LYS42O, LYS5P, LYS7P, LYS81O, LYS81P, LYS91P, MET158O, MET1P, MET248O, MET271P, MET281O, MET281P, MET71O, PHE213P, PHE226O, PHE243O, PHE247O, PHE300O, PHE300P, PHE320O, PRO147O, PRO154O, PRO217P, PRO307P, SER153O, SER19P, SER20P, SER21P, SER231O, SER232O, SER237O, SER266O, SER276P, SER28P, SER310P, SER32P, SER366O, SER366P, SER4P, SER72O, THR11P, THR233O, THR24P, THR29P, THR371O, THR79O, TYR23P, TYR251O, TYR288O, TYR290O, TYR301P, TYR353P, TYR365O, TYR365P, TYR38O, TYR69O, TYR88P, VAL222P, VAL224O, VAL224P, VAL239O, VAL262O, VAL267O, VAL267P, VAL277O, VAL277P, VAL284O, VAL285O, VAL287O, VAL362O, VAL362P, VAL367O, VAL367P, VAL40O, VAL6P
• O-W: ALA2W, ASN364O, ASP369O, LEU368O, LEU3W, LYS5W, MET1W, SER366O, SER4W, VAL367O
• P-W: ALA264P, ALA291P, ALA2W, ARG234P, ARG238P, ARG259P, ARG27W, ARG73P, ASN269P, ASP10W, ASP175W, ASP221W, ASP31W, ASP369P, ASP39P, ASP85P, ASP85W, GLN16W, GLN26W, GLN278P, GLN292P, GLN41P, GLU148P, GLU214W, GLU240P, GLU282P, GLU282W, GLU286P, GLU289P, GLU297W, GLU373P, GLY261P, GLY273P, GLY296P, HIS225P, HIS225W, HIS89W, ILE82W, LEU258P, LEU263P, LEU272P, LEU314P, LEU3W, LEU8W, LYS22W, LYS265P, LYS268P, LYS268W, LYS42P, LYS5W, LYS7W, LYS81P, MET1W, MET281P, PHE320P, SER266P, SER4W, TYR251P, TYR288P, VAL262P, VAL267P, VAL277P, VAL284P, VAL285P, VAL287P, VAL324P, VAL6W
• W-Y: ALA275Y, ARG234W, ARG238W, ARG259W, ARG27Y, ARG73W, ASN364W, ASP10Y, ASP175Y, ASP221Y, ASP31Y, ASP369W, ASP39W, ASP85W, ASP85Y, GLN16Y, GLN26Y, GLN41W, GLU148W, GLU214Y, GLU240W, GLU282Y, GLU289W, GLU297Y, GLU373W, GLY273Y, GLY296W, GLY30Y, HIS225W, HIS225Y, HIS89Y, ILE82Y, LYS22Y, LYS265W, LYS268Y, LYS42W, LYS5Y, LYS7Y, LYS81W, SER28Y, VAL362W
• Y-Z: ALA275Z, ARG234Y, ARG238Y, ARG259Y, ARG27Z, ARG73Y, ASN306Z, ASN364Y, ASP10Z, ASP175Z, ASP221Z, ASP31Z, ASP369Y, ASP39Y, ASP85Y, ASP85Z, GLN16Z, GLN26Z, GLN41Y, GLU148Y, GLU214Z, GLU240Y, GLU282Z, GLU289Y, GLU297Z, GLU373Y, GLY235Y, GLY273Z, GLY296Y, GLY30Z, HIS225Y, HIS225Z, HIS89Z, ILE82Z, LYS215Z, LYS22Z, LYS265Y, LYS268Z, LYS42Y, LYS5Z, LYS7Z, LYS81Y, SER28Z, VAL362Y