2YHM

structure of respiratory syncytial virus nucleocapsid protein, p212121 crystal form

• Total interactions analyzed: 55
• Total true interactions: 30
• Strongest Interaction:
  • Chains: A-J
  • Int. Res.: 229
  • Norm. En. per Res.: -3.6478
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-84.8096	-121.2802	-599.607	-805.6969	228	16	22	26284	10	67	57
A-C	0.0	0.0	-22.7786	-22.7786	18	1	3	1130	0	3	2
A-D	0.0	0.0	-0.02	-0.02	2	0	0	12	0	0	0
A-H	0.0	0.0	-0.2567	-0.2567	2	0	0	35	0	0	0
A-I	0.0	0.0	-24.9939	-24.9939	19	2	3	1200	0	3	2
A-J	-102.3835	-120.1541	-612.802	-835.3397	229	31	23	27029	10	67	57
B-C	-82.089	-125.0432	-612.784	-819.9161	233	27	22	26770	10	68	61
B-D	-11.6317	0.0	-31.8909	-43.5226	16	5	3	1364	0	3	2
B-E	0.0	0.0	-0.2561	-0.2561	2	0	0	35	0	0	0
B-I	0.0	0.0	-0.0347	-0.0347	2	0	0	12	0	0	0
B-J	0.0	0.0	-18.4661	-18.4661	18	1	3	1030	0	2	1
C-D	-72.5528	-120.6816	-580.031	-773.2654	231	25	20	25876	10	69	60
C-E	-31.2794	0.0	-5.2299	-36.5093	18	21	3	1564	0	3	2
C-F	0.0	0.0	-0.3955	-0.3955	2	0	0	45	0	0	0
C-J	0.0	0.0	-0.001	-0.001	2	0	0	3	0	0	0
D-E	-88.3889	-127.4463	-629.061	-844.8961	238	27	21	27021	10	68	61
D-F	-7.3341	0.0	-26.9881	-34.3222	20	8	3	1382	0	3	2
D-G	0.0	0.0	-0.0432	-0.0432	2	0	0	16	0	0	0
E-F	-108.3876	-122.9119	-575.789	-807.0885	232	41	22	26765	10	70	62
E-G	0.0	0.0	-18.6023	-18.6023	18	2	3	1070	0	3	1
E-H	0.0	0.0	-0.0045	-0.0045	2	0	0	6	0	0	0
F-G	-87.9885	-123.3721	-618.671	-830.0316	231	40	23	27175	10	69	57
F-H	-2.4634	0.0	-20.6124	-23.0758	19	1	3	1109	0	3	1
F-I	0.0	0.0	-0.0092	-0.0092	2	0	0	7	0	0	0
G-H	-106.8676	-123.5963	-613.101	-843.5649	232	26	22	26700	10	68	60
G-I	-10.5756	0.0	-32.4227	-42.9983	18	6	3	1398	0	2	2
G-J	0.0	0.0	-0.0764	-0.0764	2	0	0	20	0	0	0
H-I	-78.6756	-122.3793	-551.294	-752.3489	229	28	19	25208	10	68	60
H-J	-11.521	0.0	-32.0288	-43.5498	19	8	3	1423	0	3	2
I-J	-71.591	-122.239	-579.74	-773.5699	229	25	20	25944	10	70	59

Interface residues

• A-B: ALA173B, ALA229A, ALA244A, ALA250A, ALA264A, ALA264B, ALA275B, ALA279B, ALA291A, ALA298A, ALA2B, ALA309B, ALA349B, ALA372A, ALA70A, ALA86A, ALA86B, ARG234A, ARG238A, ARG259A, ARG27B, ARG73A, ARG84A, ARG84B, ASN13B, ASN249A, ASN269A, ASN269B, ASN305B, ASN306B, ASN343B, ASN360A, ASN360B, ASN364A, ASN364B, ASN37A, ASN45A, ASN9B, ASP10B, ASP155A, ASP15B, ASP175B, ASP221A, ASP221B, ASP31B, ASP369A, ASP39A, ASP78A, ASP85A, ASP85B, GLN16B, GLN230A, GLN255A, GLN26B, GLN278A, GLN278B, GLN283B, GLN292A, GLN356B, GLN41A, GLU148A, GLU211B, GLU214B, GLU240A, GLU280B, GLU282A, GLU282B, GLU286A, GLU286B, GLU289A, GLU297A, GLU297B, GLU359A, GLU373A, GLU374A, GLU77A, GLY174B, GLY227A, GLY235A, GLY236A, GLY241A, GLY245A, GLY252A, GLY261A, GLY273A, GLY273B, GLY295A, GLY296A, GLY299A, GLY30B, GLY361A, GLY75A, GLY87B, HIS216B, HIS218B, HIS225A, HIS225B, HIS274B, HIS319B, HIS43A, HIS89B, ILE220B, ILE228A, ILE242A, ILE25B, ILE270B, ILE303B, ILE363A, ILE363B, ILE80A, ILE82A, ILE82B, LEU12B, LEU161A, LEU17B, LEU18B, LEU246A, LEU258A, LEU263A, LEU272A, LEU272B, LEU294A, LEU304A, LEU304B, LEU311B, LEU312A, LEU314A, LEU331A, LEU346B, LEU357A, LEU357B, LEU368A, LEU370A, LEU375A, LEU3B, LEU74A, LEU83A, LEU83B, LEU8B, LYS14B, LYS215B, LYS22B, LYS265A, LYS265B, LYS268A, LYS268B, LYS293A, LYS308B, LYS358A, LYS42A, LYS5B, LYS7A, LYS7B, LYS81A, LYS81B, LYS91B, MET158A, MET1B, MET248A, MET271B, MET281A, MET281B, MET71A, PHE213B, PHE226A, PHE243A, PHE247A, PHE300A, PHE300B, PHE320A, PRO147A, PRO154A, PRO217B, PRO307B, SER19B, SER20B, SER21B, SER231A, SER232A, SER237A, SER266A, SER266B, SER276B, SER28B, SER310B, SER32B, SER366A, SER366B, SER4B, SER72A, THR11B, THR233A, THR24B, THR29B, THR371A, THR79A, TRP260A, TYR23B, TYR251A, TYR288A, TYR290A, TYR301B, TYR353B, TYR365A, TYR365B, TYR38A, TYR69A, TYR88B, VAL222A, VAL222B, VAL224A, VAL224B, VAL239A, VAL262A, VAL267A, VAL267B, VAL277A, VAL277B, VAL284A, VAL285A, VAL287A, VAL324A, VAL362A, VAL362B, VAL367A, VAL367B, VAL40A, VAL6B
• A-C: ALA275C, ALA2C, ALA372A, ARG234A, ASN364A, ASP369A, GLN278C, LEU368A, LEU370A, LEU3C, LYS22C, LYS5C, MET1C, SER366A, SER4C, THR371A, TYR23C, VAL367A
• A-D: MET1D, THR371A
• A-H: MET1A, THR371H
• A-I: ALA275A, ALA2A, ALA372I, ARG234I, ASN364I, ASP369I, GLN278A, LEU368I, LEU370I, LEU3A, LYS22A, LYS5A, MET1A, SER366I, SER4A, THR371I, TYR23A, TYR365I, VAL367I
• A-J: ALA173A, ALA229J, ALA244J, ALA250J, ALA264A, ALA264J, ALA275A, ALA279A, ALA291J, ALA298J, ALA2A, ALA309A, ALA349A, ALA372J, ALA70J, ALA86A, ALA86J, ARG234J, ARG238J, ARG259J, ARG27A, ARG73J, ARG84A, ARG84J, ASN13A, ASN249J, ASN269A, ASN269J, ASN305A, ASN306A, ASN343A, ASN360A, ASN360J, ASN364A, ASN364J, ASN37J, ASN45J, ASN9A, ASP10A, ASP155J, ASP15A, ASP175A, ASP221A, ASP221J, ASP31A, ASP369J, ASP39J, ASP78J, ASP85A, ASP85J, GLN16A, GLN230J, GLN255J, GLN26A, GLN278A, GLN278J, GLN283A, GLN292J, GLN356A, GLN41J, GLU148J, GLU211A, GLU214A, GLU240J, GLU280A, GLU282A, GLU282J, GLU286A, GLU286J, GLU289J, GLU297A, GLU297J, GLU359J, GLU373J, GLU374J, GLU77J, GLY174A, GLY227J, GLY235J, GLY236J, GLY241J, GLY245J, GLY252J, GLY261J, GLY273A, GLY273J, GLY295J, GLY296J, GLY299J, GLY30A, GLY361J, GLY75J, GLY87A, HIS216A, HIS218A, HIS225A, HIS225J, HIS274A, HIS319A, HIS43J, HIS89A, ILE220A, ILE228J, ILE242J, ILE25A, ILE270A, ILE303A, ILE363A, ILE363J, ILE80J, ILE82A, ILE82J, LEU12A, LEU161J, LEU17A, LEU18A, LEU246J, LEU258J, LEU263J, LEU272A, LEU272J, LEU294J, LEU304A, LEU304J, LEU311A, LEU312J, LEU314J, LEU331J, LEU346A, LEU357A, LEU357J, LEU368J, LEU370J, LEU375J, LEU3A, LEU74J, LEU83A, LEU83J, LEU8A, LYS14A, LYS215A, LYS22A, LYS265A, LYS265J, LYS268A, LYS268J, LYS293J, LYS308A, LYS358J, LYS42J, LYS5A, LYS7A, LYS7J, LYS81A, LYS81J, LYS91A, MET158J, MET1A, MET248J, MET271A, MET281A, MET281J, MET71J, PHE213A, PHE226J, PHE243J, PHE247J, PHE300A, PHE300J, PHE320J, PRO147J, PRO154J, PRO217A, PRO307A, SER19A, SER20A, SER21A, SER231J, SER232J, SER237J, SER266A, SER266J, SER276A, SER28A, SER310A, SER32A, SER366A, SER366J, SER4A, SER72J, THR11A, THR233J, THR24A, THR29A, THR371J, THR79J, TRP260J, TYR23A, TYR251J, TYR288J, TYR290J, TYR301A, TYR353A, TYR365A, TYR365J, TYR38J, TYR69J, TYR88A, VAL222A, VAL222J, VAL224A, VAL224J, VAL239J, VAL262J, VAL267A, VAL267J, VAL277A, VAL277J, VAL284J, VAL285J, VAL287J, VAL323A, VAL324J, VAL362A, VAL362J, VAL367A, VAL367J, VAL40J, VAL6A
• B-C: ALA173C, ALA229B, ALA244B, ALA250B, ALA264B, ALA264C, ALA275C, ALA279C, ALA291B, ALA298B, ALA2C, ALA309C, ALA349C, ALA372B, ALA70B, ALA86B, ALA86C, ARG150B, ARG234B, ARG238B, ARG259B, ARG27C, ARG73B, ARG84B, ARG84C, ASN13C, ASN249B, ASN269B, ASN269C, ASN305C, ASN306C, ASN343C, ASN360B, ASN360C, ASN364B, ASN364C, ASN37B, ASN45B, ASN9C, ASP10C, ASP155B, ASP15C, ASP175C, ASP221B, ASP221C, ASP31C, ASP369B, ASP39B, ASP78B, ASP85B, ASP85C, GLN16C, GLN230B, GLN255B, GLN26C, GLN278B, GLN278C, GLN283C, GLN292B, GLN356C, GLN41B, GLU148B, GLU211C, GLU214C, GLU240B, GLU280C, GLU282B, GLU282C, GLU286B, GLU286C, GLU289B, GLU297B, GLU297C, GLU359B, GLU373B, GLU374B, GLU77B, GLY174C, GLY227B, GLY235B, GLY236B, GLY241B, GLY245B, GLY252B, GLY261B, GLY273B, GLY273C, GLY295B, GLY296B, GLY299B, GLY30C, GLY361B, GLY361C, GLY75B, GLY87C, HIS216C, HIS218C, HIS225B, HIS225C, HIS274C, HIS319C, HIS43B, HIS89C, ILE220C, ILE228B, ILE242B, ILE25C, ILE270C, ILE303C, ILE363B, ILE363C, ILE80B, ILE80C, ILE82B, ILE82C, LEU12C, LEU161B, LEU171C, LEU17C, LEU18C, LEU246B, LEU258B, LEU263B, LEU272B, LEU272C, LEU294B, LEU304B, LEU304C, LEU311C, LEU312B, LEU314B, LEU331B, LEU346C, LEU357B, LEU357C, LEU368B, LEU370B, LEU375B, LEU3C, LEU74B, LEU83B, LEU83C, LEU8C, LYS14C, LYS215C, LYS22C, LYS265B, LYS265C, LYS268B, LYS268C, LYS293B, LYS308C, LYS358B, LYS42B, LYS5C, LYS7C, LYS81B, LYS81C, LYS91C, MET158B, MET1C, MET248B, MET271C, MET281B, MET281C, MET71B, PHE213C, PHE226B, PHE243B, PHE247B, PHE300B, PHE300C, PHE320B, PRO147B, PRO154B, PRO217C, PRO307C, SER153B, SER19C, SER20C, SER21C, SER231B, SER232B, SER237B, SER266B, SER266C, SER276C, SER28C, SER310C, SER32C, SER366B, SER366C, SER4C, SER72B, THR11C, THR233B, THR24C, THR29C, THR371B, THR79B, THR79C, TRP260B, TYR23C, TYR251B, TYR288B, TYR290B, TYR301C, TYR353C, TYR365B, TYR365C, TYR38B, TYR69B, TYR88C, VAL222B, VAL222C, VAL224B, VAL224C, VAL239B, VAL262B, VAL267B, VAL267C, VAL277B, VAL277C, VAL284B, VAL285B, VAL287B, VAL324B, VAL362B, VAL362C, VAL367B, VAL367C, VAL40B, VAL6C
• B-D: ALA275D, ALA2D, ARG234B, ASN364B, ASP369B, LEU368B, LEU370B, LEU3D, LYS22D, LYS5D, MET1D, SER366B, SER4D, TYR23D, TYR365B, VAL367B
• B-E: MET1E, THR371B
• B-I: MET1B, THR371I
• B-J: ALA275B, ALA2B, ALA372J, ARG234J, ASN364J, ASP369J, GLN278B, LEU368J, LEU370J, LEU3B, LYS22B, LYS5B, MET1B, SER366J, SER4B, THR371J, TYR23B, VAL367J
• C-D: ALA173D, ALA229C, ALA244C, ALA250C, ALA264C, ALA264D, ALA275D, ALA279D, ALA291C, ALA298C, ALA2D, ALA309D, ALA349D, ALA372C, ALA70C, ALA86C, ALA86D, ARG150C, ARG234C, ARG238C, ARG259C, ARG27D, ARG73C, ARG84C, ARG84D, ASN13D, ASN249C, ASN269C, ASN269D, ASN305D, ASN306D, ASN343D, ASN360C, ASN360D, ASN364C, ASN364D, ASN37C, ASN45C, ASN9D, ASP10D, ASP155C, ASP15D, ASP175D, ASP221C, ASP221D, ASP31D, ASP369C, ASP39C, ASP78C, ASP85C, ASP85D, GLN16D, GLN230C, GLN255C, GLN26D, GLN278C, GLN278D, GLN283D, GLN292C, GLN356D, GLN41C, GLU148C, GLU211D, GLU214D, GLU240C, GLU280D, GLU282C, GLU282D, GLU286C, GLU286D, GLU289C, GLU297C, GLU297D, GLU359C, GLU373C, GLU374C, GLU77C, GLY174D, GLY227C, GLY235C, GLY236C, GLY241C, GLY245C, GLY252C, GLY261C, GLY273C, GLY273D, GLY295C, GLY296C, GLY299C, GLY30D, GLY361C, GLY75C, GLY87D, HIS216D, HIS218D, HIS225C, HIS225D, HIS274D, HIS319D, HIS43C, HIS89D, ILE220D, ILE228C, ILE242C, ILE25D, ILE270C, ILE270D, ILE303D, ILE363C, ILE363D, ILE80C, ILE80D, ILE82C, ILE82D, LEU12D, LEU161C, LEU171D, LEU17D, LEU18D, LEU246C, LEU258C, LEU263C, LEU272C, LEU272D, LEU294C, LEU304C, LEU304D, LEU311D, LEU312C, LEU314C, LEU331C, LEU346D, LEU357C, LEU357D, LEU368C, LEU370C, LEU375C, LEU3D, LEU74C, LEU83C, LEU83D, LEU8D, LYS14D, LYS215D, LYS22D, LYS265C, LYS265D, LYS268C, LYS268D, LYS293C, LYS308D, LYS358C, LYS42C, LYS5D, LYS7D, LYS81C, LYS81D, LYS91D, MET158C, MET1D, MET248C, MET271D, MET281C, MET281D, MET71C, PHE213D, PHE226C, PHE243C, PHE247C, PHE300C, PHE300D, PHE320C, PRO147C, PRO154C, PRO217D, PRO307D, SER153C, SER19D, SER20D, SER21D, SER231C, SER232C, SER237C, SER266C, SER266D, SER276D, SER28D, SER310D, SER32D, SER366C, SER366D, SER4D, SER72C, THR11D, THR233C, THR24D, THR29D, THR371C, THR79C, TRP260C, TYR23D, TYR251C, TYR288C, TYR290C, TYR301D, TYR353D, TYR365C, TYR365D, TYR38C, TYR69C, TYR88D, VAL222D, VAL224C, VAL224D, VAL239C, VAL262C, VAL267C, VAL267D, VAL277C, VAL277D, VAL284C, VAL285C, VAL287C, VAL324C, VAL362C, VAL362D, VAL367C, VAL367D, VAL40C, VAL6D
• C-E: ALA275E, ALA2E, ARG234C, ASN364C, ASP369C, GLN278E, LEU368C, LEU370C, LEU3E, LYS22E, LYS5E, MET1E, SER366C, SER4E, THR371C, TYR23E, TYR365C, VAL367C
• C-F: MET1F, THR371C
• C-J: MET1C, THR371J
• D-E: ALA173E, ALA229D, ALA244D, ALA250D, ALA264D, ALA264E, ALA275E, ALA279E, ALA291D, ALA298D, ALA2E, ALA309E, ALA349E, ALA372D, ALA70D, ALA86D, ALA86E, ARG234D, ARG238D, ARG259D, ARG27E, ARG73D, ARG84D, ARG84E, ASN13E, ASN249D, ASN269D, ASN269E, ASN305E, ASN306E, ASN343E, ASN360D, ASN360E, ASN364D, ASN364E, ASN37D, ASN45D, ASN9E, ASP10E, ASP155D, ASP15E, ASP175E, ASP221D, ASP221E, ASP31E, ASP369D, ASP39D, ASP78D, ASP85D, ASP85E, GLN16E, GLN230D, GLN255D, GLN26E, GLN278D, GLN278E, GLN283E, GLN292D, GLN356E, GLN41D, GLU148D, GLU211E, GLU214E, GLU240D, GLU280D, GLU280E, GLU282D, GLU282E, GLU286D, GLU286E, GLU289D, GLU297D, GLU297E, GLU359D, GLU373D, GLU374D, GLU77D, GLY174E, GLY227D, GLY235D, GLY236D, GLY241D, GLY245D, GLY252D, GLY261D, GLY273D, GLY273E, GLY295D, GLY296D, GLY299D, GLY30E, GLY361D, GLY361E, GLY75D, GLY87E, HIS216E, HIS218E, HIS225D, HIS225E, HIS274D, HIS274E, HIS319E, HIS43D, HIS89E, ILE220E, ILE228D, ILE242D, ILE25E, ILE270D, ILE270E, ILE303E, ILE363D, ILE363E, ILE80D, ILE80E, ILE82D, ILE82E, LEU12E, LEU161D, LEU171E, LEU17E, LEU18E, LEU246D, LEU258D, LEU263D, LEU272D, LEU272E, LEU294D, LEU304D, LEU304E, LEU311E, LEU312D, LEU314D, LEU331D, LEU346E, LEU357D, LEU357E, LEU368D, LEU370D, LEU375D, LEU3E, LEU74D, LEU83D, LEU83E, LEU8E, LYS14E, LYS215E, LYS22E, LYS265D, LYS265E, LYS268D, LYS268E, LYS293D, LYS308E, LYS358D, LYS42D, LYS5E, LYS7E, LYS81D, LYS81E, LYS91E, MET158D, MET1E, MET248D, MET257D, MET271D, MET271E, MET281D, MET281E, MET71D, PHE213E, PHE226D, PHE243D, PHE247D, PHE300D, PHE300E, PHE320D, PRO147D, PRO154D, PRO217E, PRO307E, SER19E, SER20E, SER21E, SER231D, SER232D, SER237D, SER266D, SER266E, SER276E, SER28E, SER310E, SER32E, SER366D, SER366E, SER4E, SER72D, THR11E, THR233D, THR24E, THR29E, THR371D, THR79D, THR79E, TRP260D, TYR23E, TYR251D, TYR288D, TYR290D, TYR301D, TYR301E, TYR353E, TYR365D, TYR365E, TYR38D, TYR69D, TYR88E, VAL222D, VAL222E, VAL224D, VAL224E, VAL239D, VAL256D, VAL262D, VAL267D, VAL267E, VAL277D, VAL277E, VAL284D, VAL285D, VAL287D, VAL324D, VAL362D, VAL362E, VAL367D, VAL367E, VAL40D, VAL6E
• D-F: ALA275F, ALA2F, ALA372D, ARG234D, ASN364D, ASP369D, GLN278F, LEU368D, LEU370D, LEU3F, LYS22F, LYS5F, MET1F, SER366D, SER4F, THR371D, TYR23F, TYR365D, VAL367D, VAL6F
• D-G: MET1G, THR371D
• E-F: ALA173F, ALA229E, ALA244E, ALA250E, ALA264E, ALA264F, ALA275F, ALA279F, ALA291E, ALA298E, ALA2F, ALA309F, ALA349F, ALA372E, ALA70E, ALA86E, ALA86F, ARG150E, ARG234E, ARG238E, ARG259E, ARG27F, ARG73E, ARG84E, ARG84F, ASN13F, ASN249E, ASN269E, ASN269F, ASN305F, ASN306F, ASN343F, ASN360E, ASN360F, ASN364E, ASN364F, ASN37E, ASN45E, ASN9F, ASP10F, ASP155E, ASP15F, ASP175F, ASP221E, ASP221F, ASP31F, ASP369E, ASP39E, ASP78E, ASP85E, ASP85F, GLN16F, GLN230E, GLN255E, GLN26F, GLN278E, GLN278F, GLN283F, GLN292E, GLN356F, GLN41E, GLU148E, GLU211F, GLU214F, GLU240E, GLU280F, GLU282E, GLU282F, GLU286E, GLU286F, GLU289E, GLU297E, GLU297F, GLU359E, GLU373E, GLU374E, GLU77E, GLY174F, GLY227E, GLY235E, GLY236E, GLY241E, GLY245E, GLY252E, GLY261E, GLY273E, GLY273F, GLY295E, GLY296E, GLY299E, GLY30F, GLY361E, GLY75E, GLY87F, HIS216F, HIS218F, HIS225E, HIS225F, HIS274F, HIS319F, HIS43E, HIS89F, ILE220F, ILE228E, ILE242E, ILE25F, ILE270F, ILE303F, ILE363E, ILE363F, ILE80E, ILE80F, ILE82E, ILE82F, LEU12F, LEU161E, LEU171F, LEU17F, LEU18F, LEU246E, LEU258E, LEU263E, LEU272E, LEU272F, LEU294E, LEU304E, LEU304F, LEU311F, LEU312E, LEU314E, LEU331E, LEU346F, LEU357E, LEU357F, LEU368E, LEU370E, LEU375E, LEU3F, LEU74E, LEU83E, LEU83F, LEU8F, LYS14F, LYS215F, LYS22F, LYS265E, LYS265F, LYS268E, LYS268F, LYS293E, LYS308F, LYS358E, LYS42E, LYS5F, LYS7F, LYS81E, LYS81F, LYS91F, MET158E, MET1F, MET248E, MET271F, MET281E, MET281F, MET71E, PHE213F, PHE226E, PHE243E, PHE247E, PHE300E, PHE300F, PHE320E, PRO147E, PRO154E, PRO217F, PRO307F, SER153E, SER19F, SER20F, SER21F, SER231E, SER232E, SER237E, SER266E, SER266F, SER276F, SER28F, SER310F, SER32F, SER366E, SER366F, SER4F, SER72E, THR11F, THR233E, THR24F, THR29F, THR371E, THR79E, THR79F, TRP260E, TYR23F, TYR251E, TYR288E, TYR290E, TYR301F, TYR353F, TYR365E, TYR365F, TYR38E, TYR69E, TYR88F, VAL222E, VAL222F, VAL224E, VAL224F, VAL239E, VAL262E, VAL267E, VAL267F, VAL277E, VAL277F, VAL284E, VAL285E, VAL287E, VAL362E, VAL362F, VAL367E, VAL367F, VAL40E, VAL6F, VAL90F
• E-G: ALA275G, ALA2G, ALA372E, ARG234E, ASN364E, ASP369E, GLN278G, LEU368E, LEU370E, LEU3G, LYS22G, LYS5G, MET1G, SER366E, SER4G, THR371E, TYR23G, VAL367E
• E-H: MET1H, THR371E
• F-G: ALA173G, ALA229F, ALA244F, ALA250F, ALA264F, ALA264G, ALA275G, ALA279G, ALA291F, ALA298F, ALA2G, ALA309G, ALA349G, ALA372F, ALA70F, ALA86F, ALA86G, ARG150F, ARG234F, ARG238F, ARG259F, ARG27G, ARG73F, ARG84F, ARG84G, ASN13G, ASN249F, ASN269F, ASN269G, ASN305G, ASN306G, ASN343G, ASN360F, ASN360G, ASN364F, ASN364G, ASN37F, ASN45F, ASN9G, ASP10G, ASP155F, ASP15G, ASP175G, ASP221F, ASP221G, ASP31G, ASP369F, ASP39F, ASP78F, ASP85F, ASP85G, GLN16G, GLN230F, GLN255F, GLN26G, GLN278F, GLN278G, GLN283G, GLN292F, GLN356G, GLN41F, GLU148F, GLU211G, GLU214G, GLU240F, GLU280G, GLU282F, GLU282G, GLU286F, GLU286G, GLU289F, GLU297F, GLU297G, GLU359F, GLU373F, GLU374F, GLU77F, GLY174G, GLY227F, GLY235F, GLY236F, GLY241F, GLY245F, GLY252F, GLY261F, GLY273F, GLY273G, GLY295F, GLY296F, GLY299F, GLY30G, GLY361F, GLY361G, GLY75F, GLY87G, HIS216G, HIS218G, HIS225F, HIS225G, HIS274G, HIS319G, HIS43F, HIS89G, ILE220G, ILE228F, ILE242F, ILE25G, ILE270G, ILE303G, ILE363F, ILE363G, ILE80F, ILE80G, ILE82F, ILE82G, LEU12G, LEU161F, LEU171G, LEU17G, LEU18G, LEU246F, LEU258F, LEU263F, LEU272F, LEU272G, LEU294F, LEU304F, LEU304G, LEU311G, LEU312F, LEU314F, LEU331F, LEU346G, LEU357F, LEU357G, LEU368F, LEU370F, LEU375F, LEU3G, LEU74F, LEU83F, LEU83G, LEU8G, LYS14G, LYS215G, LYS22G, LYS265F, LYS265G, LYS268F, LYS268G, LYS293F, LYS308G, LYS358F, LYS42F, LYS5G, LYS7G, LYS81F, LYS81G, LYS91G, MET158F, MET1G, MET248F, MET271G, MET281F, MET281G, MET71F, PHE213G, PHE226F, PHE243F, PHE247F, PHE300F, PHE300G, PHE320F, PRO147F, PRO154F, PRO217G, PRO307G, SER19G, SER20G, SER21G, SER231F, SER232F, SER237F, SER266F, SER266G, SER276G, SER28G, SER310G, SER32G, SER366F, SER366G, SER4G, SER72F, THR11G, THR233F, THR24G, THR29G, THR371F, THR79F, TYR23G, TYR251F, TYR288F, TYR290F, TYR301G, TYR353G, TYR365F, TYR365G, TYR38F, TYR69F, TYR88G, VAL222F, VAL222G, VAL224F, VAL224G, VAL239F, VAL262F, VAL267F, VAL267G, VAL277F, VAL277G, VAL284F, VAL285F, VAL287F, VAL323G, VAL362F, VAL362G, VAL367F, VAL367G, VAL40F, VAL6G, VAL90G
• F-H: ALA275H, ALA2H, ALA372F, ARG234F, ASN364F, ASP369F, GLN278H, LEU368F, LEU370F, LEU3H, LYS22H, LYS5H, MET1H, SER366F, SER4H, THR371F, TYR23H, TYR365F, VAL367F
• F-I: MET1I, THR371F
• G-H: ALA173H, ALA229G, ALA244G, ALA250G, ALA264G, ALA264H, ALA275H, ALA279H, ALA291G, ALA298G, ALA2H, ALA309H, ALA349H, ALA372G, ALA70G, ALA86G, ALA86H, ARG150G, ARG234G, ARG238G, ARG259G, ARG27H, ARG73G, ARG84G, ARG84H, ASN13H, ASN249G, ASN269G, ASN269H, ASN305H, ASN306H, ASN343H, ASN360G, ASN360H, ASN364G, ASN364H, ASN37G, ASN45G, ASN9H, ASP10H, ASP155G, ASP15H, ASP175H, ASP221G, ASP221H, ASP31H, ASP369G, ASP39G, ASP78G, ASP85G, ASP85H, GLN16H, GLN230G, GLN255G, GLN26H, GLN278G, GLN278H, GLN283H, GLN292G, GLN356H, GLN41G, GLU148G, GLU211H, GLU214H, GLU240G, GLU280H, GLU282G, GLU282H, GLU286G, GLU286H, GLU289G, GLU297G, GLU297H, GLU359G, GLU373G, GLU374G, GLU77G, GLY174H, GLY227G, GLY235G, GLY236G, GLY241G, GLY245G, GLY252G, GLY261G, GLY273G, GLY273H, GLY295G, GLY296G, GLY299G, GLY30H, GLY361G, GLY75G, GLY87H, HIS216H, HIS218H, HIS225G, HIS225H, HIS274H, HIS319H, HIS43G, HIS89H, ILE220H, ILE228G, ILE228H, ILE242G, ILE25H, ILE270H, ILE303H, ILE363G, ILE363H, ILE80G, ILE80H, ILE82G, ILE82H, LEU12H, LEU161G, LEU171H, LEU17H, LEU18H, LEU246G, LEU258G, LEU263G, LEU272G, LEU272H, LEU294G, LEU304G, LEU304H, LEU311H, LEU312G, LEU314G, LEU331G, LEU346H, LEU357G, LEU357H, LEU368G, LEU370G, LEU375G, LEU3H, LEU74G, LEU83G, LEU83H, LEU8H, LYS14H, LYS215H, LYS22H, LYS265G, LYS265H, LYS268G, LYS268H, LYS293G, LYS308H, LYS358G, LYS42G, LYS5H, LYS7H, LYS81G, LYS81H, LYS91H, MET158G, MET1H, MET248G, MET271H, MET281G, MET281H, MET71G, PHE213H, PHE226G, PHE243G, PHE247G, PHE300G, PHE300H, PHE320G, PRO147G, PRO154G, PRO217H, PRO307H, SER19H, SER20H, SER21H, SER231G, SER232G, SER237G, SER266G, SER266H, SER276H, SER28H, SER310H, SER32H, SER366G, SER366H, SER4H, SER72G, THR11H, THR233G, THR24H, THR29H, THR371G, THR79G, THR79H, TRP260G, TYR23H, TYR251G, TYR288G, TYR290G, TYR301H, TYR353H, TYR365G, TYR365H, TYR38G, TYR69G, TYR88H, VAL222G, VAL222H, VAL224G, VAL224H, VAL239G, VAL262G, VAL267G, VAL267H, VAL277G, VAL277H, VAL284G, VAL285G, VAL287G, VAL324G, VAL362G, VAL362H, VAL367G, VAL367H, VAL40G, VAL6H
• G-I: ALA275I, ALA2I, ARG234G, ASN364G, ASP369G, GLN278I, LEU368G, LEU370G, LEU3I, LYS22I, LYS5I, MET1I, SER366G, SER4I, THR371G, TYR23I, TYR365G, VAL367G
• G-J: MET1J, THR371G
• H-I: ALA173I, ALA229H, ALA244H, ALA250H, ALA264H, ALA264I, ALA275I, ALA279I, ALA291H, ALA298H, ALA2I, ALA309I, ALA349I, ALA372H, ALA70H, ALA86H, ALA86I, ARG234H, ARG238H, ARG259H, ARG27I, ARG73H, ARG84H, ARG84I, ASN13I, ASN249H, ASN269H, ASN269I, ASN305I, ASN306I, ASN343I, ASN360H, ASN360I, ASN364H, ASN364I, ASN37H, ASN9I, ASP10I, ASP155H, ASP15I, ASP175I, ASP221H, ASP221I, ASP31I, ASP369H, ASP39H, ASP78H, ASP85H, ASP85I, GLN16I, GLN230H, GLN255H, GLN26I, GLN278H, GLN278I, GLN283I, GLN292H, GLN356I, GLN41H, GLU148H, GLU211I, GLU214I, GLU240H, GLU280I, GLU282H, GLU282I, GLU286H, GLU286I, GLU289H, GLU297H, GLU297I, GLU359H, GLU373H, GLU374H, GLU77H, GLY174I, GLY227H, GLY235H, GLY236H, GLY241H, GLY245H, GLY252H, GLY261H, GLY273H, GLY273I, GLY295H, GLY296H, GLY299H, GLY30I, GLY361H, GLY75H, GLY87I, HIS216I, HIS218I, HIS225H, HIS225I, HIS274I, HIS319I, HIS43H, HIS89I, ILE220I, ILE228H, ILE242H, ILE25I, ILE270H, ILE270I, ILE303I, ILE363H, ILE363I, ILE80H, ILE80I, ILE82H, ILE82I, LEU12I, LEU171I, LEU17I, LEU18I, LEU246H, LEU258H, LEU263H, LEU272H, LEU272I, LEU294H, LEU304I, LEU311I, LEU312H, LEU314H, LEU331H, LEU346I, LEU357H, LEU357I, LEU368H, LEU370H, LEU375H, LEU3I, LEU74H, LEU83H, LEU83I, LEU8I, LYS14I, LYS215I, LYS22I, LYS265H, LYS265I, LYS268H, LYS268I, LYS293H, LYS308I, LYS358H, LYS42H, LYS5I, LYS7I, LYS81H, LYS81I, LYS91I, MET158H, MET1I, MET248H, MET257H, MET271H, MET271I, MET281H, MET281I, MET71H, PHE213I, PHE226H, PHE243H, PHE247H, PHE300H, PHE300I, PHE320H, PRO147H, PRO154H, PRO217I, PRO307I, SER19I, SER20I, SER21I, SER231H, SER232H, SER237H, SER266H, SER266I, SER276I, SER28I, SER310I, SER32I, SER366H, SER366I, SER4I, SER72H, THR11I, THR233H, THR24I, THR29I, THR371H, THR79H, THR79I, TRP260H, TYR23I, TYR251H, TYR288H, TYR290H, TYR301I, TYR353I, TYR365H, TYR365I, TYR38H, TYR69H, TYR88I, VAL222I, VAL224H, VAL224I, VAL239H, VAL262H, VAL267H, VAL267I, VAL277H, VAL277I, VAL284H, VAL285H, VAL287H, VAL324H, VAL362H, VAL362I, VAL367H, VAL367I, VAL40H, VAL6I
• H-J: ALA275J, ALA2J, ALA372H, ARG234H, ASN364H, ASP369H, GLN278J, LEU368H, LEU370H, LEU3J, LYS22J, LYS5J, MET1J, SER366H, SER4J, THR371H, TYR23J, TYR365H, VAL367H
• I-J: ALA173J, ALA229I, ALA244I, ALA250I, ALA264I, ALA264J, ALA275J, ALA279J, ALA291I, ALA298I, ALA2J, ALA309J, ALA349J, ALA372I, ALA70I, ALA86I, ALA86J, ARG150I, ARG234I, ARG238I, ARG259I, ARG27J, ARG73I, ARG84I, ARG84J, ASN13J, ASN249I, ASN269I, ASN269J, ASN305J, ASN306J, ASN343J, ASN360I, ASN360J, ASN364I, ASN364J, ASN37I, ASN45I, ASN9J, ASP10J, ASP155I, ASP15J, ASP175J, ASP221I, ASP221J, ASP31J, ASP369I, ASP39I, ASP78I, ASP85I, ASP85J, GLN16J, GLN230I, GLN255I, GLN26J, GLN278I, GLN278J, GLN283J, GLN292I, GLN356J, GLN41I, GLU148I, GLU211J, GLU214J, GLU240I, GLU280J, GLU282I, GLU282J, GLU286I, GLU286J, GLU289I, GLU297I, GLU297J, GLU359I, GLU373I, GLU374I, GLU77I, GLY174J, GLY227I, GLY235I, GLY236I, GLY241I, GLY245I, GLY252I, GLY261I, GLY273I, GLY273J, GLY295I, GLY296I, GLY299I, GLY30J, GLY361I, GLY361J, GLY75I, GLY87J, HIS216J, HIS218J, HIS225I, HIS225J, HIS274J, HIS319J, HIS43I, HIS89J, ILE220J, ILE228I, ILE242I, ILE25J, ILE270J, ILE303J, ILE363I, ILE363J, ILE80I, ILE80J, ILE82I, ILE82J, LEU12J, LEU161I, LEU171J, LEU17J, LEU18J, LEU246I, LEU258I, LEU263I, LEU272I, LEU272J, LEU294I, LEU304J, LEU311J, LEU312I, LEU314I, LEU331I, LEU346J, LEU357I, LEU357J, LEU368I, LEU370I, LEU375I, LEU3J, LEU74I, LEU83I, LEU83J, LEU8J, LYS14J, LYS215J, LYS22J, LYS265I, LYS265J, LYS268I, LYS268J, LYS293I, LYS308J, LYS358I, LYS42I, LYS5J, LYS7J, LYS81I, LYS81J, LYS91J, MET158I, MET1J, MET248I, MET271J, MET281I, MET281J, MET71I, PHE213J, PHE226I, PHE243I, PHE247I, PHE300I, PHE300J, PHE320I, PRO147I, PRO154I, PRO217J, PRO307J, SER19J, SER20J, SER21J, SER231I, SER232I, SER237I, SER266I, SER266J, SER276J, SER28J, SER310J, SER32J, SER366I, SER366J, SER4J, SER72I, THR11J, THR233I, THR24J, THR29J, THR371I, THR79I, TRP260I, TYR23J, TYR251I, TYR288I, TYR290I, TYR301J, TYR353J, TYR365I, TYR365J, TYR38I, TYR69I, TYR88J, VAL222J, VAL224I, VAL224J, VAL239I, VAL262I, VAL267I, VAL267J, VAL277I, VAL277J, VAL284I, VAL285I, VAL287I, VAL324I, VAL362I, VAL362J, VAL367I, VAL367J, VAL40I, VAL6J