2YDX

crystal structure of human s-adenosylmethionine synthetase 2, beta subunit

• Total interactions analyzed: 10
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 124
  • Norm. En. per Res.: -3.3267
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-10.5578	-29.8652	-140.129	-180.552	62	10	0	5860	1	16	21
A-C	-57.6788	-119.3788	-235.449	-412.5066	124	14	0	8811	6	57	56
A-E	0.0	0.0	-0.0756	-0.0756	6	0	0	13	0	3	6
C-D	0.0	0.0	-0.1981	-0.1981	8	0	0	65	0	3	6
C-E	0.0	0.0	-9.3108	-9.3108	12	0	0	320	0	2	1
D-E	-48.7475	-116.7033	-238.07	-403.5208	125	14	0	9138	8	58	57

Interface residues

• A-B: ALA287A, ARG148B, ARG219A, ARG238B, ARG289A, ARG291A, ASN144A, ASN292A, ASP141A, ASP241B, ASP281A, ASP296B, CYS297B, GLN217A, GLN218A, GLN255A, GLN288A, GLN294A, GLU149B, GLU150B, GLU236B, GLU260A, GLU301B, GLY142A, GLY246B, GLY286A, GLY304B, HIS215A, ILE244B, ILE279A, ILE305B, LEU156A, LEU234B, LEU240B, LEU285A, LEU300B, LEU303B, LYS237B, LYS245B, LYS299B, MET256A, PHE220A, PHE248B, PRO145A, PRO146A, PRO146B, PRO242B, PRO278A, PRO283A, PRO290A, SER243B, SER282A, SER298B, THR143A, THR247B, THR257A, THR280A, THR302B, TRP216A, TYR147A, TYR259A, VAL284A
• A-C: ALA55A, ALA55C, ALA63A, ALA63C, ALA77A, ALA77C, ARG30A, ARG30C, ARG327A, ARG327C, ARG329A, ARG329C, ARG61A, ARG61C, ARG62A, ARG62C, ARG64A, ARG64C, ASN337A, ASN337C, ASN71A, ASN71C, ASN76A, ASN76C, ASP202A, ASP202C, ASP325A, ASP325C, ASP74A, ASP74C, ASP84A, ASP84C, CYS58A, CYS58C, GLN205A, GLN205C, GLN330A, GLN330C, GLN69A, GLN69C, GLN86A, GLN86C, GLU190A, GLU190C, GLU193A, GLU193C, GLU336A, GLU336C, GLU68A, GLU68C, GLY57A, GLY57C, HIS334A, HIS334C, HIS54A, HIS54C, HIS79A, HIS79C, HIS80A, HIS80C, HIS83A, HIS83C, ILE324A, ILE324C, ILE81A, ILE81C, ILE82A, ILE82C, LEU192A, LEU192C, LEU319A, LEU319C, LEU323A, LEU323C, LEU32A, LEU32C, LEU338A, LEU338C, LYS191A, LYS191C, LYS203A, LYS326A, LYS326C, LYS66A, LYS66C, PHE201A, PHE201C, PHE206A, PHE206C, PHE322A, PHE322C, PHE333A, PHE333C, PHE60A, PHE67A, PHE67C, PHE85A, PHE85C, PRO321A, PRO321C, PRO65A, PRO65C, PRO87A, PRO87C, SER318A, SER318C, THR198A, THR198C, THR331A, THR331C, TRP320A, TRP320C, TRP328A, TRP328C, VAL189A, VAL189C, VAL199A, VAL199C, VAL332A, VAL332C, VAL56A, VAL56C, VAL70A, VAL70C
• A-E: ASN208E, ASP84A, GLN330E, HIS79A, HIS80A, HIS83A
• C-D: ASN208C, ASP84D, GLN330C, GLN86D, HIS79D, HIS80D, HIS83D, LYS326C
• C-E: ARG327C, ARG327E, ARG329E, GLN330C, GLN330E, HIS334C, HIS334E, LYS326C, THR331C, THR331E, TRP328C, TRP328E
• D-E: ALA55D, ALA55E, ALA63D, ALA63E, ALA77D, ALA77E, ARG30D, ARG30E, ARG327D, ARG327E, ARG329D, ARG329E, ARG61D, ARG61E, ARG62D, ARG62E, ARG64D, ARG64E, ASN337D, ASN337E, ASN71D, ASN71E, ASN76D, ASN76E, ASP202D, ASP202E, ASP325D, ASP325E, ASP74D, ASP74E, ASP84D, ASP84E, CYS58D, CYS58E, GLN205D, GLN205E, GLN330D, GLN330E, GLN69D, GLN69E, GLN86D, GLN86E, GLU190D, GLU190E, GLU193D, GLU193E, GLU336D, GLU336E, GLU68D, GLU68E, GLY57D, GLY57E, HIS334D, HIS334E, HIS54D, HIS54E, HIS79D, HIS79E, HIS80D, HIS80E, HIS83D, HIS83E, ILE324D, ILE324E, ILE81D, ILE81E, ILE82D, ILE82E, LEU192D, LEU192E, LEU319D, LEU319E, LEU323D, LEU323E, LEU32D, LEU32E, LEU338D, LEU338E, LYS191D, LYS191E, LYS326D, LYS326E, LYS66D, LYS66E, PHE201D, PHE201E, PHE206D, PHE206E, PHE322D, PHE322E, PHE333D, PHE333E, PHE60D, PHE60E, PHE67D, PHE67E, PHE85D, PHE85E, PRO321D, PRO321E, PRO65D, PRO65E, PRO87D, PRO87E, SER318D, SER318E, THR198D, THR198E, THR331D, THR331E, THR37E, TRP320D, TRP320E, TRP328D, TRP328E, VAL189D, VAL189E, VAL199D, VAL199E, VAL332D, VAL332E, VAL56D, VAL56E, VAL70D, VAL70E