2YBB

fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876)

• Total interactions analyzed: 1128
• Total true interactions: 117
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 23
  • Norm. En. per Res.: -8.0466
• Hub Node: A(17)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
1-2	-147.287	-144.1679	-707.284	-998.7389	228	40	16	28079	13	79	77
1-3	-34.4456	-41.5088	-330.183	-406.1374	147	20	7	15396	5	47	55
1-7	0.0	3.1113	-22.2836	-19.1723	25	0	1	1256	0	3	16
2-3	-7.6605	68.6194	-150.455	-89.4961	58	12	0	5417	2	16	17
2-7	-37.9808	-58.8574	-143.26	-240.0983	83	13	8	7059	4	25	18
3-4	0.0	3.2678	-247.092	-243.8242	87	27	5	10627	1	20	21
3-5	-35.7356	-18.3912	-228.781	-282.9078	99	12	2	8850	4	26	26
3-7	-32.5421	-7.8802	-227.578	-268.0003	92	16	4	9322	8	52	61
3-8	-32.2931	-98.8566	-137.992	-269.1417	59	14	1	5877	6	30	24
4-5	-206.3549	-44.35	-729.115	-979.8199	236	50	15	30645	16	84	83
4-6	-22.5327	-38.5654	-266.585	-327.6831	110	19	5	11104	5	17	25
4-7	-15.0388	-57.1503	-71.7467	-143.9358	29	5	1	2761	3	9	13
4-8	-40.5491	-48.962	-267.059	-356.5701	98	7	5	10594	4	40	21
5-6	-24.7186	-4.8316	-82.2974	-111.8477	50	3	1	3502	0	12	5
5-8	-15.0966	-54.1877	-167.114	-236.3983	57	8	6	6338	7	12	12
6-8	-73.8047	-24.6256	-335.23	-433.6602	117	49	15	14578	3	35	42
7-8	-7.1403	28.5007	-93.8449	-72.4845	63	7	3	4626	0	22	24
A-B	-157.8236	-68.7173	-630.71	-857.2509	235	34	12	24391	7	59	55
A-C	-10.4192	-14.5424	-49.0437	-74.0053	33	3	0	2048	3	11	14
A-D	-2.6955	4.325	-22.3086	-20.6791	33	0	1	1151	0	9	12
A-E	-56.5787	-11.0475	-260.202	-327.8282	107	12	4	10220	1	31	30
A-F	0.0	2.7196	-0.1839	2.5357	7	0	0	72	0	9	8
A-G	-149.533	-58.3171	-289.033	-496.8832	72	16	2	9575	2	20	11
A-I	-41.4902	20.3773	-220.33	-241.4429	89	19	5	8575	0	17	16
A-J	-5.299	-10.6535	-31.0101	-46.9625	23	1	0	1119	0	4	5
A-f	0.0	0.7642			4
B-I	-120.2026	-30.2565	-476.629	-627.0881	168	32	26	19353	2	17	18
B-b	-45.0961	-220.7255			16
B-f	-6.2141	-34.3324			10
C-D	-42.749	-86.6658	-455.268	-584.6829	156	14	10	17626	12	37	38
C-E	-11.8338	0.662	-140.257	-151.4288	52	2	1	4919	2	3	1
C-F	-22.5862	23.826	-312.611	-311.3712	112	15	7	13572	1	38	29
C-G	-12.9418	-56.9971	-281.469	-351.4079	111	4	7	10582	5	17	12
C-J	0.0	0.0	-0.0065	-0.0065	2	0	0	4	0	0	0
C-K	0.0	0.0	-0.1411	-0.1411	3	0	0	46	0	0	0
C-c	0.0	27.3833			10
C-e	-13.8136	5.4243			8
D-E	0.0	-16.9204	-143.019	-159.9394	90	8	4	6392	0	18	27
D-F	-10.261	-20.4012	-86.8696	-117.5318	38	4	1	3338	1	9	13
D-G	-69.3402	-14.6611	-206.522	-290.5233	62	11	4	7676	2	14	17
D-H	-61.2053	-3.4302	-330.898	-395.5335	111	12	5	14098	0	19	27
D-J	-64.4833	-87.8074	-276.105	-428.3957	83	8	6	9643	7	51	39
D-d	-4.8237	1.08			6
E-F	0.0	0.0	-0.1006	-0.1006	3	0	0	26	0	1	0
E-G	-30.5987	-66.5552	-161.802	-258.956	45	5	3	5787	3	12	14
E-J	-12.4273	-15.1842	-194.319	-221.9305	59	7	15	7107	1	6	7
E-c	-25.341	5.4304			9
F-G	-7.8546	-61.1481	-84.354	-153.3567	49	1	2	3515	3	12	24
F-a	0.0	4.9563	0.0	4.9563	2	0	0	0	0	0	0
F-b	-5.0657	-36.8246			11
G-H	-35.8817	-107.4911	-41.699	-185.0718	23	6	0	1470	7	21	7
G-J	0.0	0.0	-0.01	-0.01	2	0	0	7	0	0	0
H-J	0.0	0.0	-0.0041	-0.0041	2	0	0	7	0	0	2
K-a	-3.7373	0.0	0.0	-3.7373	2	0	0	0	0	0	0
L-M	-63.9963	-103.3525	-883.731	-1051.0799	300	50	36	38074	6	38	40
L-N	-66.3903	-53.376	-705.264	-825.0303	249	28	20	29221	5	16	20
L-O	-43.7904	-19.6607	-290.063	-353.5141	150	9	14	12343	2	19	20
L-P	0.0	-4.2906	-0.0769	-4.3675	13	0	0	32	0	2	2
L-Q	-57.6053	-21.2573	-347.539	-426.4016	97	16	10	13861	0	14	5
L-R	-22.5024	2.3594	-81.7424	-101.8854	39	3	1	3336	0	11	3
L-S	0.0	0.0	-25.5649	-25.5649	22	0	0	1050	0	3	0
L-T	0.0	0.0	-15.4165	-15.4165	18	0	0	569	0	0	4
L-U	0.0	0.0	-38.4481	-38.4481	35	1	3	2120	0	0	1
L-V	0.0	3.6519	-65.1299	-61.478	45	2	0	2756	0	2	4
L-W	-43.622	-28.7241	-452.462	-524.8081	141	13	12	17480	2	18	14
L-X	-91.8139	-22.6708	-275.903	-390.3876	93	16	5	11752	3	9	6
M-N	0.0	0.0	-1.3022	-1.3022	8	0	0	117	0	1	2
M-O	-23.8097	-3.6447	-215.142	-242.5964	87	12	3	9138	3	20	18
M-P	-16.0915	-10.9817	-63.7389	-90.8121	29	5	0	2699	0	10	8
M-Q	0.0	0.0	-0.0025	-0.0025	2	0	0	3	0	0	2
M-S	-64.9868	-19.5046	-280.025	-364.5164	83	17	3	11049	1	11	9
M-T	-30.3107	-44.9007	-434.114	-509.3254	145	20	18	16745	3	29	39
M-V	0.0	2.5469	-34.852	-32.3051	21	4	0	1553	0	4	3
N-O	0.0	0.0	-0.0051	-0.0051	2	0	0	6	0	0	0
N-Q	-23.4654	-22.3397	-251.24	-297.0451	87	7	7	10246	2	27	13
N-R	-41.877	-61.1187	-408.344	-511.3398	157	21	8	16774	3	29	19
N-S	-8.843	-5.0877	-54.5853	-68.516	30	4	0	2397	0	4	2
N-U	-24.7744	-11.9362	-358.5	-395.2106	115	9	7	15876	4	19	21
N-W	0.0	0.0	-1.1228	-1.1228	5	0	0	79	0	0	0
O-P	-65.117	-45.9534	-411.615	-522.6855	109	32	12	15718	7	44	43
O-Q	-11.9576	0.0	-34.9296	-46.8872	19	1	0	1154	0	6	1
O-T	-11.6113	-22.6374	-102.583	-136.8317	44	3	3	3763	2	13	14
O-V	-4.058	-13.1903	-424.387	-441.6353	109	13	9	16281	3	23	24
O-W	0.0	0.0	-0.0586	-0.0586	6	0	0	22	0	0	1
O-X	0.0	0.7304	-58.2226	-57.4922	47	4	4	2600	0	5	4
P-Q	0.0	-37.5404	-44.8657	-82.4061	27	5	0	1738	1	10	7
P-T	-58.7335	-89.9269	-170.163	-318.8234	53	11	1	6124	6	20	13
Q-R	0.0	0.0	-11.1717	-11.1717	8	2	1	556	0	0	0
Q-U	-4.2385	0.0	-28.6974	-32.9359	21	0	0	966	0	2	1
R-S	0.0	-3.2472	-56.8167	-60.0639	18	1	0	1998	1	6	6
T-V	0.0	0.0	-8.6033	-8.6033	8	0	0	305	0	1	2
U-W	-10.7461	0.0	-27.6605	-38.4066	13	2	0	924	0	0	0
V-X	0.0	0.0	-0.159	-0.159	4	0	0	42	0	0	0
W-X	-24.0466	-6.7435	-165.59	-196.3801	70	13	9	6989	1	4	12
Y-d	-8.0926	-38.1116			8
a-b	-173.5045	-65.3261			37
a-c	-12.9562	-13.1615			10
a-d	-2.1924	4.2244			6
a-e	-42.7356	-10.8349			20
a-f	0.0	2.6011			2
a-g	-141.4283	-55.5181			23
a-i	-52.9659	19.4892			14
a-j	-3.5513	-11.3284			3
b-i	-127.6234	-40.3213			23
c-d	-43.2221	-95.772			21
c-e	-11.5395	1.3779			4
c-f	-20.7351	23.3257			15
c-g	-14.3059	-59.9725			7
d-e	-8.1258	-3.1719			13
d-f	-10.0884	-19.0357			5
d-g	-78.0054	-7.3669			14
d-h	-48.2959	-3.6624			15
d-j	-64.0349	-93.9692			21
e-g	-35.6016	-70.0113			11
e-j	-28.4208	-17.1747			8
f-g	-10.7197	-64.7005			10
g-h	-8.7771	-72.3262			7

Interface residues

• 1-2: ALA1312, ALA1411, ALA1421, ALA1482, ALA162, ALA1771, ALA1791, ALA1871, ALA191, ALA1971, ALA252, ALA262, ALA2801, ALA3401, ALA642, ALA842, ALA912, ALA932, ARG1041, ARG1351, ARG1391, ARG1401, ARG1441, ARG1472, ARG1492, ARG1531, ARG1751, ARG1961, ARG232, ARG242, ARG2601, ARG322, ARG3341, ARG3461, ARG4331, ARG4381, ASN1372, ASN1901, ASN1981, ASN3431, ASP1031, ASP1091, ASP1382, ASP1431, ASP1701, ASP3391, ASP982, CYS1242, CYS1282, CYS1442, CYS1821, CYS3531, CYS882, GLN1202, GLN1352, GLN2531, GLN352, GLN362, GLN712, GLN812, GLN861, GLU1081, GLU1232, GLU132, GLU1371, GLU1392, GLU1432, GLU1461, GLU1512, GLU1642, GLU1782, GLU1802, GLU1931, GLU212, GLU2651, GLU2851, GLU3511, GLU592, GLU942, GLU951, GLU952, GLU971, GLY1262, GLY1361, GLY1732, GLY1761, GLY1781, GLY1941, GLY2131, GLY221, GLY222, GLY2561, GLY2621, GLY2811, GLY2941, GLY3541, GLY622, GLY922, GLY991, HIS1292, HIS1721, HIS1741, HIS1742, HIS1752, HIS1772, HIS201, HIS3501, ILE1321, ILE1342, ILE1811, ILE2541, ILE272, ILE2871, ILE2901, ILE2911, ILE3291, ILE3311, ILE412, LEU1002, LEU1252, LEU1502, LEU1542, LEU1632, LEU1711, LEU1881, LEU1921, LEU1951, LEU2111, LEU2511, LEU2841, LEU302, LEU312, LEU3301, LEU3441, LEU4361, LEU862, LEU902, LEU962, LYS1021, LYS1212, LYS1501, LYS172, LYS2141, LYS231, LYS2591, LYS3551, LYS892, MET1891, MET282, MET3371, MET3411, MET612, PHE1011, PHE3471, PHE662, PRO1322, PRO1402, PRO192, PRO1991, PRO202, PRO2571, PRO2611, PRO292, PRO2991, PRO3321, PRO4321, PRO4341, PRO981, SER1001, SER1272, SER1911, SER2551, SER261, SER2951, SER3361, SER3521, SER4351, SER652, SER682, SER872, SER961, THR1302, THR142, THR1462, THR3451, THR552, THR582, THR852, TRP2121, TRP271, TRP2791, TRP3421, TRP4371, TRP972, TYR1051, TYR1311, TYR1331, TYR1381, TYR1412, TYR1801, TYR181, TYR182, TYR2641, TYR3481, TYR672, TYR692, TYR702, TYR881, TYR992, VAL1222, VAL1291, VAL1332, VAL1341, VAL1452, VAL1731, VAL1762, VAL1792, VAL211, VAL2581, VAL2631, VAL3281, VAL3351, VAL3381, VAL4311, VAL532, VAL602, VAL632, VAL822
• 1-3: ALA1033, ALA1053, ALA1771, ALA1791, ALA1971, ALA3491, ALA3641, ALA3721, ALA3891, ALA4031, ALA443, ALA803, ALA813, ALA863, ARG1013, ARG1563, ARG1623, ARG1893, ARG1961, ARG2001, ARG2053, ARG3601, ARG3971, ARG4403, ARG463, ASN1143, ASN1901, ASN1981, ASN3691, ASN3861, ASP2013, ASP3831, ASP4041, ASP983, CYS1813, CYS1821, CYS1843, CYS343, CYS3531, CYS3561, CYS3591, CYS4001, CYS453, CYS833, GLN1043, GLN2081, GLN3781, GLU1023, GLU1093, GLU1583, GLU1931, GLU1983, GLU2043, GLU3511, GLU3611, GLU3801, GLU3851, GLU3951, GLU4393, GLY1063, GLY1781, GLY1941, GLY2063, GLY2131, GLY3541, GLY3621, GLY3651, GLY3791, GLY3961, GLY433, HIS1153, HIS1833, HIS2083, HIS3501, ILE1811, ILE1823, ILE2033, ILE3741, ILE3941, ILE423, LEU1123, LEU1133, LEU1951, LEU2011, LEU3701, LEU3871, LEU3901, LEU3911, LEU3931, LEU4021, LEU4353, LEU493, LEU793, LYS1853, LYS2021, LYS3551, LYS3731, LYS3821, LYS4383, LYS783, MET1073, MET3671, MET473, PHE1103, PHE1573, PHE1593, PHE2023, PHE2103, PHE333, PHE3471, PHE3661, PHE3711, PHE3991, PRO1991, PRO2031, PRO2041, PRO3581, PRO3921, PRO4011, PRO413, PRO4423, PRO773, SER3521, SER3981, SER403, THR1113, THR1553, THR1603, THR2093, THR3571, THR853, TRP2121, TRP4081, TYR1403, TYR1801, TYR3481, VAL1003, VAL1083, VAL1533, VAL1883, VAL2073, VAL3631, VAL3681, VAL4071, VAL503, VAL843, VAL993
• 1-7: ALA3721, ARG817, ASN3691, ASP3831, GLN3781, GLU3801, GLY3751, GLY3771, GLY3791, HIS3501, HIS907, HIS927, HIS947, ILE3741, LEU3701, LEU797, LYS3731, LYS3821, LYS4281, LYS787, LYS807, PHE3711, THR3761, TRP3421, VAL3681
• 2-3: ALA502, ALA642, ARG1783, ARG2053, ARG242, ARG422, ARG4403, ARG452, ASP1973, ASP2013, ASP2153, GLU1232, GLU1923, GLU1983, GLU2043, GLU212, GLU442, GLU472, GLU482, GLU592, GLY1963, GLY2063, GLY2123, GLY542, GLY622, ILE2033, ILE2113, ILE412, ILE462, LEU2003, LEU2183, LYS1853, MET2143, MET612, PHE1913, PHE2023, PHE2103, PHE2163, PHE662, PHE722, PRO2193, PRO432, PRO4423, PRO572, SER652, SER682, THR2093, THR2133, THR552, THR562, THR582, TYR672, TYR692, VAL1222, VAL1883, VAL1993, VAL602, VAL632
• 2-7: ALA1177, ALA1197, ALA1227, ALA1257, ALA1277, ALA1297, ALA642, ALA897, ARG1147, ARG1217, ARG1237, ARG422, ARG887, ASP1207, ASP982, GLN1202, GLN352, GLN712, GLU1022, GLU1102, GLU1247, GLU442, GLU472, GLU657, GLU942, GLU952, GLY1052, GLY1067, GLY1072, GLY1092, GLY1152, GLY622, GLY762, HIS792, HIS907, HIS927, HIS947, ILE1062, ILE1087, ILE412, ILE462, ILE917, LEU1002, LEU1042, LEU1107, LEU1187, LEU1267, LEU847, LEU867, LEU937, LYS1077, MET612, PHE1157, PHE1172, PHE1287, PHE662, PHE677, PHE722, PRO1082, PRO1097, PRO432, PRO572, PRO742, PRO877, SER1182, SER652, SER682, THR1012, THR1032, THR1057, THR1117, THR1122, THR582, THR752, TRP402, TRP972, TYR672, TYR692, TYR702, TYR992, VAL1112, VAL1192, VAL732
• 3-4: ALA1053, ALA1273, ALA3234, ARG1333, ARG1563, ARG1613, ARG1803, ARG2453, ARG3034, ARG93, ASN1143, ASN2463, ASN3064, ASP1183, ASP1323, ASP3044, CYS1193, CYS1223, CYS1283, GLN1313, GLN3084, GLU1093, GLU1293, GLU1363, GLU1413, GLU1503, GLU1583, GLU2483, GLU3184, GLU3224, GLU3334, GLY1253, GLY1263, GLY1383, GLY3344, HIS1153, HIS3154, HIS3274, HIS3304, HIS3364, ILE3094, ILE3254, LEU1123, LEU1133, LEU1173, LEU1303, LEU1393, LEU1513, LEU3164, LEU3174, LYS1243, LYS3294, LYS3394, MET3214, PHE1103, PHE1573, PHE3284, PHE3354, PRO1163, PRO1203, PRO1523, PRO3014, PRO3054, PRO3074, PRO3114, PRO3124, PRO3134, SER3204, THR1113, THR1213, THR1343, THR1553, THR3104, THR3194, THR3324, TRP2473, TYR1373, TYR1403, TYR1433, TYR1543, TYR3264, VAL1083, VAL1084, VAL1353, VAL1533, VAL2323, VAL3244
• 3-5: ALA1273, ALA1685, ALA1725, ALA1735, ALA2443, ARG1013, ARG1333, ARG1635, ARG1715, ARG1863, ARG1895, ARG1935, ARG2453, ARG2703, ARG2763, ARG2783, ARG93, ASN2463, ASP1323, ASP2283, ASP2683, ASP293, CYS1283, CYS2303, CYS483, GLN1043, GLN1313, GLU1293, GLU1363, GLU1413, GLU1615, GLU1695, GLU2483, GLU2503, GLU2513, GLU2733, GLU2813, GLU363, GLU6303, GLY1253, GLY1263, GLY1383, GLY1625, GLY1805, GLY1865, GLY1875, GLY1915, GLY2723, GLY273, HIS4283, ILE1655, ILE1665, ILE2293, ILE2883, ILE6293, LEU1303, LEU1393, LEU1745, LEU1815, LEU1955, LEU323, LEU963, LYS1243, LYS1855, LYS1905, LYS373, MET203, MET2493, MET473, PHE1595, PHE1705, PHE1835, PHE243, PHE333, PHE4323, PRO1795, PRO2313, PRO2533, PRO313, PRO6283, SER1885, SER1945, SER2713, SER353, THR1343, THR1825, THR2523, THR2693, TRP1965, TRP2473, TYR1373, TYR1433, TYR1645, TYR1845, TYR1925, TYR283, VAL1353, VAL233, VAL303
• 3-7: ALA1277, ALA1297, ALA357, ALA577, ALA707, ALA777, ALA897, ARG1613, ARG1623, ARG1783, ARG2053, ARG307, ARG817, ARG857, ARG887, ASP1183, ASP1653, ASP1773, ASP2153, ASP367, ASP397, ASP617, ASP717, CYS1193, CYS1223, GLU1583, GLU1793, GLU2043, GLU327, GLU347, GLU657, GLY2123, GLY2173, GLY627, GLY647, GLY837, HIS1153, HIS1633, HIS1673, HIS1683, HIS2083, HIS767, HIS907, HIS927, HIS947, ILE2033, ILE2113, ILE417, ILE827, ILE917, LEU1173, LEU1267, LEU1703, LEU1763, LEU637, LEU687, LEU697, LEU797, LEU867, LEU937, LYS1663, LYS337, LYS787, LYS807, MET2143, MET557, PHE1287, PHE1573, PHE1593, PHE2103, PHE2163, PHE377, PHE407, PRO1163, PRO1203, PRO1693, PRO387, PRO667, PRO747, PRO877, SER587, SER607, SER737, THR1213, THR1603, THR2093, THR2133, THR567, TYR427, VAL1643, VAL2073, VAL727
• 3-8: ALA1078, ALA2443, ALA608, ALA618, ALA628, ALA738, ALA838, ARG1803, ARG2413, ARG2433, ARG2453, ARG2703, ARG868, ASN2463, ASN758, ASP1183, ASP1233, ASP1773, CYS1088, CYS1193, CYS1223, CYS568, CYS598, GLN1313, GLU2483, GLU2733, GLU718, GLU748, GLU858, GLY1253, GLY2723, GLY558, GLY848, HIS1673, ILE1753, ILE548, ILE688, LEU2363, LEU2383, LEU2753, LEU588, LYS1243, LYS1663, LYS898, PHE2423, PRO1098, PRO1203, PRO1693, PRO728, PRO778, SER2713, SER578, THR1108, THR1213, TRP2473, TYR668, TYR698, TYR878, VAL708
• 4-5: ALA1004, ALA1074, ALA1115, ALA1685, ALA1725, ALA1735, ALA2294, ALA2514, ALA3724, ALA505, ALA695, ARG1165, ARG1335, ARG1475, ARG1715, ARG1895, ARG1935, ARG2404, ARG2694, ARG3674, ARG3714, ARG4094, ARG424, ARG645, ARG675, ARG734, ARG875, ARG915, ASN1125, ASN205, ASN245, ASN2454, ASN3064, ASN3774, ASN475, ASP1065, ASP1205, ASP1315, ASP1495, ASP1785, ASP2314, ASP2474, ASP3044, ASP3604, ASP4064, ASP4084, ASP515, ASP565, ASP625, ASP845, GLN3084, GLN3794, GLN774, GLU1024, GLU1155, GLU1175, GLU1395, GLU1545, GLU185, GLU2274, GLU3334, GLU3414, GLU3524, GLU674, GLU714, GLU735, GLY1064, GLY1095, GLY1535, GLY1765, GLY1805, GLY1875, GLY1915, GLY215, GLY2334, GLY235, GLY2434, GLY3344, GLY3404, GLY3544, GLY3614, GLY3624, GLY545, GLY604, GLY654, GLY795, GLY855, HIS1295, HIS1445, HIS3364, HIS584, HIS634, HIS724, ILE1355, ILE2304, ILE3094, ILE3574, ILE525, ILE594, LEU1044, LEU1054, LEU1075, LEU1145, LEU1215, LEU1365, LEU1415, LEU1465, LEU1525, LEU1745, LEU1815, LEU1955, LEU225, LEU2324, LEU2344, LEU2394, LEU255, LEU2664, LEU3534, LEU3784, LEU3814, LEU414, LEU495, LEU555, LEU585, LEU624, LEU745, LEU775, LEU994, LYS1034, LYS1345, LYS1485, LYS1775, LYS1855, LYS1905, LYS2504, LYS3294, LYS3394, LYS3694, LYS425, LYS684, LYS815, MET15, MET3644, MET4044, MET444, MET704, PHE1135, PHE1225, PHE1705, PHE3284, PHE3354, PHE3754, PHE465, PHE485, PHE664, PHE885, PHE895, PRO1385, PRO1455, PRO1515, PRO1675, PRO2254, PRO2264, PRO3074, PRO3374, PRO3384, PRO3454, PRO3654, PRO3734, PRO3824, PRO574, PRO615, PRO785, SER1105, SER1885, SER1945, SER2424, SER3594, SER3634, SER3744, SER3804, SER765, SER865, THR1055, THR1375, THR1575, THR1755, THR1825, THR2354, THR3104, THR3324, THR3464, THR595, THR644, THR694, THR744, TRP1085, TRP1965, TRP265, TRP805, TYR1505, TYR1925, TYR2464, TYR2524, TYR3264, TYR3314, TYR3434, TYR3554, TYR3564, TYR3664, TYR575, TYR605, TYR614, TYR725, TYR754, TYR814, TYR935, VAL1014, VAL1084, VAL1185, VAL2284, VAL2444, VAL2484, VAL3424, VAL3444, VAL3584, VAL3684, VAL3704, VAL3764, VAL4074, VAL535, VAL554, VAL564, VAL705, VAL715, VAL755
• 4-6: ALA1106, ALA1226, ALA446, ALA476, ALA526, ALA566, ALA816, ALA896, ARG1436, ARG1534, ARG1674, ARG3504, ARG4094, ARG424, ARG734, ARG836, ARG844, ARG946, ASN1196, ASN1206, ASN1714, ASN294, ASN784, ASP1584, ASP4064, ASP4084, ASP556, ASP864, CYS1116, CYS1406, CYS456, CYS466, GLN1256, GLN1664, GLN774, GLU1456, GLU1544, GLU1614, GLU496, GLU674, GLY1156, GLY1166, GLY1396, GLY1654, GLY314, GLY394, GLY4054, GLY426, GLY604, GLY654, GLY826, HIS1694, HIS1704, HIS584, HIS634, HIS724, ILE1236, ILE486, ILE594, ILE794, LEU1384, LEU1574, LEU414, LEU436, LEU624, LEU846, LEU884, LYS684, LYS866, LYS876, MET1176, MET4044, MET506, MET516, MET704, MET854, MET886, MET926, PHE1186, PHE1464, PHE1474, PHE1504, PHE1684, PHE416, PHE664, PRO1416, PRO1426, PRO1446, PRO574, PRO834, PRO906, SER1284, SER536, SER856, SER904, THR1354, THR546, THR644, THR694, THR804, THR824, TYR1216, TYR614, TYR814, TYR874, VAL1246, VAL1314, VAL4034, VAL404, VAL916
• 4-7: ALA777, ARG3144, ARG437, ARG467, ARG757, ASP397, GLU3184, GLU457, HIS3154, HIS3274, HIS767, ILE417, LEU3164, LEU3174, MET3214, MET447, PHE3284, PHE377, PHE407, PRO3124, PRO3134, PRO387, PRO477, PRO747, SER3204, THR3194, TYR427, TYR487, VAL3244
• 4-8: ALA1078, ALA1128, ALA328, ALA608, ALA618, ALA628, ALA658, ARG1674, ARG1678, ARG1744, ARG3034, ARG3144, ARG368, ARG734, ARG844, ARG868, ARG978, ASN1714, ASN784, ASP1584, ASP1814, CYS1018, CYS1048, CYS1088, CYS568, CYS598, CYS638, CYS988, GLN1664, GLN774, GLU1058, GLU1068, GLU1544, GLU1614, GLU1698, GLU1804, GLU1844, GLU1854, GLU1894, GLU3184, GLU3334, GLY1028, GLY1118, GLY1654, GLY398, HIS1694, HIS1704, HIS3274, HIS3304, HIS388, HIS724, ILE1138, ILE794, ILE998, LEU1038, LEU1158, LEU1574, LEU1594, LEU1824, LEU3174, LEU338, LEU588, LEU764, LYS1794, LYS3294, LYS348, MET3644, PHE1008, PHE1604, PHE1864, PHE3284, PHE378, PRO1098, PRO1648, PRO1834, PRO3114, PRO358, PRO648, PRO834, SER578, THR1108, THR1554, THR1644, THR3324, THR694, THR744, THR804, TRP1624, TYR1178, TYR1658, TYR1724, TYR3314, TYR668, TYR814, VAL1148, VAL1634, VAL318, VAL3244
• 5-6: ALA1226, ALA1685, ALA896, ARG1165, ARG1335, ARG1605, ARG1715, ASN1196, ASN1206, ASN1266, ASP1205, ASP1405, GLN1256, GLU1395, GLU1545, GLU1656, GLY1156, GLY1166, GLY1535, HIS1445, ILE1236, ILE1355, ILE1655, ILE1665, LEU1215, LEU1365, LEU1415, LEU1465, LEU1525, LEU1585, LYS1345, LYS866, LYS876, MET1176, MET886, PHE1186, PRO1385, PRO1455, PRO1515, PRO1565, PRO1675, PRO906, SER1146, SER856, THR1375, THR1555, THR1575, TYR1216, TYR1505, VAL1246
• 5-8: ALA1685, ALA1725, ALA1735, ALA608, ALA618, ALA628, ALA658, ALA678, ARG1478, ARG1605, ARG1635, ARG1715, ARG978, ASN948, ASP1288, ASP1358, CYS598, CYS638, GLU1348, GLU1545, GLU1615, GLU718, GLU928, GLY1328, GLY1625, ILE1655, ILE1665, ILE688, ILE938, LEU1298, LEU1525, LEU1585, LEU588, LEU968, LYS1338, LYS1448, LYS898, MET1368, MET958, PHE1595, PHE1705, PRO1565, PRO1675, PRO648, SER1278, SER578, THR1555, THR1575, TYR1268, TYR1318, TYR1645, TYR668, TYR698, TYR918, VAL1308, VAL708, VAL908
• 6-8: ALA1106, ALA1126, ALA1228, ALA1466, ALA1506, ALA1508, ALA1626, ALA298, ALA328, ALA566, ALA658, ALA678, ARG1436, ARG1478, ARG1488, ARG1528, ARG1666, ARG1696, ARG408, ARG836, ARG978, ASN1196, ASN1206, ASN1266, ASN1646, ASN948, ASP1238, ASP1286, ASP1288, ASP1346, ASP1358, ASP288, CYS1018, CYS1116, CYS1406, CYS988, GLN1256, GLN1468, GLN1536, GLN1556, GLN1616, GLU1208, GLU1258, GLU1456, GLU1498, GLU1656, GLU1686, GLY1096, GLY1156, GLY1166, GLY1396, GLY1608, GLY1676, GLY398, HIS388, HIS418, ILE1066, ILE1236, ILE1486, ILE998, LEU1038, LEU1298, LEU1476, LEU1546, LEU1706, LEU338, LEU968, LYS1448, LYS1518, LYS1566, LYS1576, LYS1588, LYS348, MET1086, MET1176, MET1218, MET1526, MET958, PHE1008, PHE1186, PHE1198, PHE378, PRO1386, PRO1416, PRO1426, PRO1446, PRO1458, PRO1716, PRO278, PRO308, PRO648, SER1076, SER1136, SER1146, SER1278, THR1438, THR1538, TYR1178, TYR1248, TYR1268, TYR1318, TYR1366, TYR1496, TYR1618, TYR1636, TYR268, TYR668, VAL1246, VAL1276, VAL1308, VAL1336, VAL1356, VAL1376, VAL1516, VAL1578, VAL1586, VAL318
• 7-8: ALA1078, ALA1128, ALA357, ALA838, ARG1678, ARG307, ARG437, ARG458, ARG467, ARG868, ASN488, ASN758, ASP367, ASP397, ASP497, ASP768, CYS1088, CYS538, CYS568, GLN257, GLU1058, GLU1068, GLU1698, GLU1718, GLU327, GLU347, GLU457, GLU518, GLU788, GLU858, GLY1118, GLY498, GLY848, HIS468, ILE417, ILE547, ILE548, LEU1708, LEU507, LEU508, LEU588, LYS337, LYS528, MET447, PHE317, PHE377, PHE407, PRO1098, PRO1688, PRO387, PRO477, PRO478, PRO517, PRO778, PRO808, SER828, THR1108, THR448, THR527, THR537, TYR427, TYR487, VAL1148
• A-B: ALA101A, ALA139B, ALA149B, ALA151B, ALA200A, ALA275A, ALA281B, ALA288A, ALA291B, ALA295A, ALA2A, ALA359B, ALA360B, ALA364A, ALA366B, ALA42B, ALA44B, ALA5A, ALA63A, ALA72B, ALA74A, ALA7A, ALA84A, ALA88A, ALA91B, ALA96A, ARG113B, ARG287B, ARG356A, ARG362A, ARG46B, ARG87B, ASN141A, ASN290B, ASN359A, ASN362B, ASN363A, ASN40B, ASN73A, ASN87A, ASP105A, ASP114B, ASP115B, ASP147B, ASP281A, ASP356B, ASP370A, CYS111B, CYS282A, CYS35A, GLN126A, GLN136A, GLN143B, GLN153B, GLN15A, GLN22B, GLN297B, GLN29A, GLN305A, GLN32A, GLN358B, GLN6A, GLN9A, GLU110B, GLU12B, GLU130A, GLU136B, GLU137A, GLU13A, GLU168A, GLU204A, GLU25B, GLU28A, GLU353A, GLU373B, GLU376B, GLU396A, GLU39B, GLU60A, GLU76A, GLU78A, GLU80A, GLU90B, GLY201A, GLY202A, GLY210B, GLY278A, GLY282B, GLY285A, GLY286A, GLY287A, GLY288B, GLY357A, GLY367B, GLY371A, GLY377B, GLY56A, GLY72A, GLY83A, GLY88B, GLY93B, GLY94B, HIS205A, HIS20B, HIS213B, HIS277B, HIS279A, HIS284B, HIS289A, HIS368A, HIS61A, HIS85A, ILE116A, ILE118B, ILE134A, ILE146B, ILE399A, ILE85B, ILE89B, ILE99A, LEU102A, LEU112B, LEU119B, LEU140B, LEU203A, LEU209B, LEU290A, LEU355A, LEU360A, LEU361A, LEU364B, LEU365A, LEU369A, LEU369B, LEU38B, LEU392A, LEU399B, LEU62A, LEU71B, LEU75A, LEU75B, LEU86A, LEU8A, LEU96B, LYS100A, LYS104A, LYS148B, LYS286B, LYS302A, LYS358A, LYS361B, LYS363B, LYS365B, LYS65A, LYS77A, LYS84B, LYS95B, MET370B, MET82A, PHE378B, PHE58A, PHE64A, PHE83B, PRO12A, PRO142B, PRO18B, PRO19B, PRO214B, PRO21B, PRO283B, PRO293A, PRO306B, PRO33A, PRO355B, PRO374A, PRO395B, PRO43B, SER103A, SER10A, SER212B, SER27A, SER289B, SER291A, SER292A, SER293B, SER296A, SER30A, SER31A, SER352A, SER367A, SER371B, SER374B, SER375B, SER396B, SER45B, SER73B, SER74B, SER81A, SER81B, SER82B, SER90A, SER97B, THR14A, THR1A, THR283A, THR292B, THR34A, THR36A, THR372A, THR373A, THR3A, THR76B, THR86B, TYR280A, TYR284A, TYR368B, TYR41B, TYR4A, TYR57A, TYR89A, TYR97A, TYR98A, VAL11A, VAL133A, VAL150B, VAL17B, VAL211B, VAL215B, VAL285B, VAL366A, VAL372B, VAL375A, VAL59A, VAL79A, VAL92B
• A-C: ARG244A, ARG436A, ARG438A, ASN15C, ASN16C, ASN435A, ASP20C, ASP214C, ASP216C, ASP332A, ASP433A, GLN430A, GLU429A, HIS221C, ILE19C, ILE218C, ILE226C, ILE437A, LEU21C, LEU431A, LYS217C, MET329A, PHE18C, PHE220C, PRO219C, PRO222C, PRO22C, PRO432A, SER439A, THR225C, TYR223C, TYR434A, VAL215C
• A-D: ALA236D, ARG233D, ARG238D, ARG244A, ARG436A, ARG438A, ASN435A, ASP142A, ASP433A, CYS242A, GLN240A, GLU245A, HIS225D, HIS243A, ILE241A, LEU230D, LEU235D, LYS223D, LYS226D, LYS231D, LYS234D, PHE442A, PRO239D, PRO240D, SER171A, SER228D, SER239A, SER439A, TRP227D, TYR152A, TYR237D, TYR434A, VAL229D
• A-E: ALA155A, ALA157A, ALA164A, ARG146A, ARG14E, ARG15E, ARG175A, ARG235A, ARG32E, ARG438A, ARG46A, ARG92A, ASN141A, ASN151A, ASN173A, ASN53A, ASP142A, ASP147A, ASP20E, ASP316A, ASP417A, ASP4E, ASP9E, CYS234A, CYS419A, GLN139A, GLN159A, GLN165A, GLN240A, GLN418A, GLU137A, GLU140A, GLU168A, GLU172A, GLU17E, GLU258A, GLU27E, GLU30E, GLU50A, GLY160A, GLY169A, GLY238A, GLY259A, GLY261A, GLY318A, HIS154A, HIS243A, HIS2E, ILE134A, ILE241A, ILE5E, LEU135A, LEU138A, LEU153A, LEU19E, LEU231A, LEU270A, LEU320A, LYS23E, LYS26E, LYS33E, LYS413A, LYS6E, MET441A, PHE10E, PHE150A, PHE158A, PHE236A, PHE415A, PHE425A, PHE442A, PRO162A, PRO170A, PRO233A, PRO260A, PRO8E, SER11E, SER144A, SER166A, SER171A, SER1E, SER21E, SER232A, SER239A, SER24E, SER25E, SER29E, SER36E, SER439A, THR143A, THR156A, THR161A, THR22E, THR237A, THR317A, THR3E, TYR152A, TYR37E, TYR414A, TYR416A, VAL148A, VAL149A, VAL167A, VAL174A, VAL18E, VAL257A, VAL7E
• A-F: ARG244A, ASP246A, GLU52F, GLY247A, LYS63F, TYR55F, VAL59F
• A-G: ALA155A, ALA421A, ALA423A, ARG11G, ARG235A, ARG244A, ARG2G, ARG436A, ARG438A, ARG9G, ASN435A, ASP246A, ASP327A, ASP332A, ASP333A, ASP417A, ASP433A, CYS242A, CYS419A, GLN159A, GLN23G, GLN240A, GLN3G, GLN418A, GLN430A, GLU22G, GLU245A, GLU429A, GLY238A, GLY247A, GLY424A, GLY426A, GLY5G, HIS12G, HIS243A, HIS328A, HIS6G, ILE14G, ILE241A, ILE331A, ILE428A, LEU18G, LEU248A, LEU431A, LEU7G, MET329A, MET441A, PHE21G, PHE236A, PHE425A, PHE442A, PHE4G, PRO20G, PRO249A, PRO420A, PRO427A, PRO432A, SER17G, SER19G, SER239A, SER330A, SER439A, THR156A, THR15G, THR237A, THR8G, TYR152A, TYR16G, TYR434A, VAL10G, VAL13G, VAL422A
• A-I: ALA275A, ALA32I, ALA33I, ALA364A, ALA36I, ALA74I, ARG146A, ARG356A, ARG362A, ARG52I, ASN141A, ASN359A, ASN363A, ASN71I, ASP132A, ASP142A, ASP281A, CYS282A, CYS304A, CYS326A, CYS51I, GLN126A, GLN136A, GLN139A, GLN305A, GLN308A, GLU130A, GLU137A, GLU140A, GLU39I, GLU53I, GLY278A, GLY285A, GLY286A, GLY287A, GLY357A, HIS252A, HIS279A, HIS289A, HIS323A, HIS368A, HIS61A, ILE134A, LEU135A, LEU138A, LEU250A, LEU290A, LEU360A, LEU361A, LEU365A, LEU369A, LEU50I, LEU55I, LEU70I, LYS129A, LYS65A, PHE307A, PHE324A, PRO249A, PRO35I, PRO41I, PRO73I, SER144A, SER291A, SER292A, SER306A, SER367A, SER38I, SER40I, SER48I, SER54I, SER67I, SER69I, SER75I, THR143A, THR283A, THR309A, THR37I, TYR280A, TYR284A, TYR57A, VAL133A, VAL325A, VAL34I, VAL366A, VAL42I, VAL49I, VAL68I, VAL72I
• A-J: ARG15J, ARG16J, ARG408A, ARG438A, ASP417A, CYS346A, CYS411A, GLN418A, GLU409A, LYS413A, MET343A, MET441A, PHE14J, PHE415A, PHE442A, SER18J, SER412A, THR17J, THR347A, TYR10J, TYR414A, TYR416A, VAL410A
• A-f: ARG104f, GLU351A, HIS289A, LYS110f
• B-I: ALA106B, ALA149B, ALA151B, ALA157B, ALA255B, ALA256B, ALA281B, ALA300B, ALA311B, ALA314B, ALA32I, ALA33I, ALA36I, ALA59I, ALA60I, ALA66I, ALA72B, ALA74I, ALA91B, ARG102B, ARG145B, ARG287B, ARG46B, ARG52I, ARG56I, ARG62I, ARG70B, ARG77I, ARG87B, ASN104B, ASN154B, ASN162B, ASN290B, ASN313B, ASN71I, ASP147B, ASP308B, ASP380B, CYS111B, CYS51I, GLN143B, GLN153B, GLN156B, GLN276B, GLN297B, GLN305B, GLN329B, GLN58I, GLU103B, GLU110B, GLU161B, GLU376B, GLU39I, GLU53I, GLU90B, GLY280B, GLY282B, GLY288B, GLY320B, GLY323B, GLY57I, GLY61I, GLY88B, GLY93B, GLY94B, HIS158B, HIS164B, HIS254B, HIS277B, HIS284B, HIS304B, HIS67B, ILE146B, ILE160B, ILE264B, ILE327B, ILE85B, ILE89B, LEU119B, LEU140B, LEU144B, LEU152B, LEU163B, LEU172B, LEU176B, LEU252B, LEU279B, LEU295B, LEU321B, LEU50I, LEU55I, LEU64I, LEU68B, LEU69B, LEU70I, LEU71B, LEU96B, LYS148B, LYS286B, LYS301B, LYS363B, LYS95B, MET105B, PHE122B, PHE307B, PHE312B, PHE322B, PHE324B, PHE83B, PRO155B, PRO283B, PRO306B, PRO35I, PRO41I, PRO63I, PRO73I, SER100B, SER175B, SER251B, SER289B, SER293B, SER294B, SER310B, SER315B, SER328B, SER371B, SER38I, SER40I, SER48I, SER54I, SER55B, SER67I, SER69I, SER73B, SER74B, SER75I, SER82B, SER97B, THR101B, THR108B, THR292B, THR326B, THR86B, THR99B, TYR107B, TYR177B, TYR296B, TYR316B, TYR325B, TYR78I, VAL109B, VAL126B, VAL150B, VAL159B, VAL253B, VAL285B, VAL299B, VAL303B, VAL309B, VAL34I, VAL42I, VAL49I, VAL65I, VAL68I, VAL72I, VAL76I, VAL92B, VAL98B
• B-b: ARG169B, ARG169b, ARG421B, ARG421b, ASN429B, ASN429b, ASN61B, ASN61b, ASP437B, ASP437b, GLU243B, GLU243b, GLU438B, GLU438b, HIS240B, HIS240b
• B-f: ARG104f, ARG133B, ARG134B, ARG49f, ARG87B, GLU100f, GLU103f, GLU136B, GLU96f, LYS84B
• C-D: ALA119D, ALA193D, ALA194D, ALA221D, ALA232C, ALA238C, ALA23C, ALA246C, ALA47D, ALA62C, ARG102D, ARG118D, ARG120D, ARG191D, ARG201D, ARG203D, ARG224D, ARG233D, ARG49D, ARG71C, ARG80C, ASN255C, ASN260C, ASN263C, ASN26C, ASN32C, ASN85C, ASP112D, ASP199D, ASP216C, ASP228C, ASP248C, ASP252C, ASP254C, ASP2D, ASP44D, ASP72C, CYS70C, GLN137C, GLU195D, GLU197D, GLU344C, GLU4D, GLY122D, GLY123D, GLY155D, GLY16D, GLY205D, GLY213D, GLY231C, GLY251C, GLY76C, HIS121D, HIS198D, HIS200D, HIS221C, HIS225D, HIS267C, HIS50D, HIS68C, ILE116D, ILE218C, ILE226C, ILE229C, ILE236C, ILE268C, ILE27C, ILE69C, ILE78C, LEU109D, LEU113D, LEU17D, LEU18D, LEU190D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU230C, LEU230D, LEU233C, LEU234C, LEU235C, LEU235D, LEU237C, LEU239C, LEU241C, LEU242C, LEU244C, LEU249C, LEU262C, LYS202D, LYS207D, LYS217C, LYS223D, LYS226D, LYS227C, LYS231D, LYS269C, MET204D, MET208D, MET211D, MET212D, MET222D, MET240C, MET43D, MET82C, PHE220C, PHE245C, PHE63C, PRO111D, PRO154D, PRO196D, PRO217D, PRO219C, PRO222C, PRO247C, PRO24C, PRO253C, PRO258C, PRO266C, PRO342C, SER114D, SER19D, SER228D, SER25C, SER28C, SER29C, SER64C, SER65C, THR225C, THR257C, THR61C, THR67C, TRP192D, TRP227D, TRP77C, TYR115D, TYR220D, TYR223C, TYR224C, TYR256C, TYR45D, TYR75C, TYR81C, TYR90D, VAL117D, VAL215C, VAL219D, VAL229D, VAL243C, VAL46D, VAL66C
• C-E: ALA50E, ALA64E, ALA66E, ARG71C, ARG80C, ASN53E, ASN74C, ASP67E, ASP72C, GLN57E, GLY48C, GLY76C, HIS54C, HIS68C, HIS83C, ILE226C, ILE229C, ILE236C, ILE45C, ILE69C, ILE78C, ILE79C, LEU233C, LEU244C, LEU43C, LEU46C, LEU49C, LEU51C, LEU69E, MET240C, MET53C, MET62E, MET82C, PHE50C, PHE58E, SER56E, SER60E, SER61E, SER63E, SER65E, THR40E, THR43E, THR47C, TRP77C, TYR75C, VAL243C, VAL47E, VAL54E, VAL55E, VAL59E, VAL68E, VAL73C
• C-F: ALA23F, ALA24F, ALA369C, ALA65F, ARG17F, ARG313C, ARG318C, ARG33F, ARG58F, ARG61F, ARG64F, ARG71F, ASN206C, ASN207C, ASN22F, ASN26C, ASN27F, ASN374C, ASN40F, ASP214C, ASP216C, ASP34F, ASP35F, ASP56F, ASP67F, ASP86F, CYS323C, GLN312C, GLN322C, GLN72F, GLU14F, GLU373C, GLU39F, GLU84F, GLU91F, GLY105C, GLY15F, GLY210C, GLY25F, GLY370C, HIS308C, HIS38F, ILE16F, ILE211C, ILE218C, ILE27C, ILE372C, ILE37F, ILE47F, ILE62F, ILE74F, ILE98F, LEU110C, LEU13F, LEU29F, LEU31F, LEU320C, LEU376C, LEU377C, LEU66F, LEU68F, LEU90F, LEU94F, LYS18F, LYS217C, LYS227C, LYS28F, LYS311C, LYS375C, LYS378C, LYS44F, LYS63F, LYS87F, MET315C, MET316C, MET32F, MET70F, PHE109C, PHE26F, PHE317C, PHE60F, PRO208C, PRO24C, PRO319C, SER106C, SER212C, SER213C, SER25C, SER28C, SER29C, SER310C, SER314C, SER321C, SER69F, SER88F, THR108C, THR203C, THR209C, THR36F, TRP19F, TRP30C, TRP31C, TRP379C, TYR104C, TYR20F, TYR21F, TYR224C, TYR55F, TYR83F, VAL215C, VAL43F, VAL59F
• C-G: ALA23C, ALA327C, ALA330C, ALA354C, ALA43G, ALA49G, ALA54G, ARG11G, ARG2G, ARG318C, ARG40G, ARG47G, ARG9G, ASN16C, ASP20C, ASP214C, ASP216C, ASP331C, CYS323C, CYS44G, GLN322C, GLN341C, GLN3G, GLN64G, GLU202C, GLU344C, GLU65G, GLU67G, GLY204C, GLY351C, GLY5G, GLY62G, HIS201C, HIS221C, HIS267C, HIS345C, HIS6G, ILE19C, ILE218C, ILE338C, ILE348C, ILE350C, LEU200C, LEU21C, LEU320C, LEU324C, LEU328C, LEU332C, LEU333C, LEU335C, LEU353C, LEU357C, LEU361C, LEU46G, LEU57G, LEU7G, LYS217C, LYS68G, LYS70G, MET315C, MET316C, PHE109C, PHE220C, PHE317C, PHE325C, PHE4G, PHE52G, PHE55G, PHE66G, PRO20G, PRO219C, PRO222C, PRO22C, PRO24C, PRO319C, PRO342C, PRO346C, PRO50G, PRO51G, SER17G, SER205C, SER212C, SER213C, SER28C, SER29C, SER321C, SER69G, THR15G, THR203C, THR334C, THR336C, THR349C, THR60G, THR63G, THR8G, TRP326C, TRP337C, TRP61G, TYR103C, TYR223C, TYR347C, TYR56G, TYR59G, VAL10G, VAL13G, VAL215C, VAL329C, VAL343C, VAL48G, VAL53G, VAL58G
• C-J: PHE245C, TYR43J
• C-K: ILE156C, LEU32K, THR36K
• C-c: ARG177C, ARG177c, ASP58C, ASP58c, HIS54C, HIS54c, HIS68C, HIS68c, LYS172C, LYS172c
• C-e: ARG177C, ARG282C, ASP67e, HIS141e, HIS161e, LYS172C, LYS287C, MET62e
• D-E: ALA221D, ALA236D, ALA41E, ALA47D, ALA48E, ALA50E, ALA51E, ALA66E, ALA70E, ARG14E, ARG15E, ARG224D, ARG233D, ARG238D, ARG32E, ARG49D, ASN53E, ASP12E, ASP4E, ASP67E, ASP80E, ASP89D, ASP9E, GLN57E, GLU76D, GLY46E, HIS200D, HIS225D, HIS2E, HIS50D, ILE5E, ILE74E, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU235D, LEU38E, LEU69E, LEU87D, LYS207D, LYS223D, LYS226D, LYS231D, LYS234D, LYS33E, LYS62D, LYS6E, LYS73E, LYS77E, LYS86D, MET204D, MET208D, MET211D, MET212D, MET222D, MET71E, MET87E, PHE10E, PHE35E, PHE89E, PRO217D, PRO8E, SER11E, SER1E, SER228D, SER232D, SER36E, SER65E, SER72E, SER88D, THR3E, THR40E, THR42E, THR43E, THR44E, TYR13E, TYR220D, TYR37E, TYR49E, TYR90D, VAL219D, VAL229D, VAL39E, VAL45E, VAL47E, VAL54E, VAL68E, VAL7E
• D-F: ALA236D, ALA65F, ARG233D, ARG238D, ARG58F, ARG61F, ARG64F, ARG71F, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU52F, ILE62F, LEU230D, LEU235D, LEU54F, LEU66F, LEU68F, LYS223D, LYS231D, LYS234D, LYS241D, LYS63F, MET70F, PHE60F, PRO239D, PRO240D, SER228D, SER232D, SER69F, TRP227D, TYR237D, TYR55F, VAL229D, VAL59F
• D-G: ALA221D, ALA236D, ALA25G, ARG11G, ARG224D, ARG233D, ARG238D, ARG24G, ARG40G, ARG71G, ASP2D, GLN23G, GLU22G, GLU4D, GLU67G, GLY140D, GLY33G, HIS12G, HIS225D, HIS28G, HIS6D, ILE14G, LEU18G, LEU216D, LEU218D, LEU230D, LEU235D, LEU3D, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, LYS70G, LYS72G, MET222D, PHE21G, PHE26G, PHE30G, PHE66G, PRO138D, PRO20G, PRO217D, PRO239D, PRO240D, PRO27G, SER17G, SER19G, SER1D, SER228D, SER232D, THR139D, THR15G, TRP227D, TYR16G, TYR220D, TYR237D, TYR29G, VAL10G, VAL13G, VAL219D, VAL229D
• D-H: ALA177D, ALA183D, ALA64H, ALA70H, ARG15D, ARG21H, ARG28D, ARG43H, ARG47H, ARG65H, ASN150D, ASN166D, ASN75H, ASP125D, ASP15H, ASP173D, ASP185D, ASP22D, ASP2D, ASP41H, ASP53H, ASP60H, ASP66H, CYS135D, CYS187D, CYS40H, CYS54H, CYS68H, GLN156D, GLN181D, GLU124D, GLU136D, GLU167D, GLU38H, GLU42H, GLU4D, GLU51H, GLU52H, GLU56H, GLU57H, GLY133D, GLY140D, GLY155D, GLY174D, HIS14D, HIS63H, HIS67H, HIS6D, HIS71H, LEU131D, LEU13H, LEU143D, LEU169D, LEU17H, LEU37H, LEU3D, LEU58H, LEU59H, LEU5D, LEU62H, LEU73H, LEU77H, LYS184D, LYS72H, LYS78H, MET179D, PHE128D, PHE149D, PHE153D, PHE171D, PHE61H, PHE74H, PRO11D, PRO137D, PRO138D, PRO151D, PRO16H, PRO176D, PRO7D, PRO8D, SER129D, SER13D, SER142D, SER180D, SER1D, SER25D, SER45H, SER46H, SER76H, SER9D, THR132D, THR139D, THR175D, THR178D, THR188D, THR18H, THR24D, THR50H, THR55H, TRP12D, TYR10D, TYR134D, TYR152D, TYR165D, VAL141D, VAL14H, VAL168D, VAL182D, VAL20H, VAL44H, VAL69H
• D-J: ALA39J, ALA41J, ARG15D, ARG201D, ARG203D, ARG27D, ARG28D, ASN47J, ASN61J, ASP172D, ASP173D, ASP199D, ASP22D, ASP36J, ASP40J, ASP59D, CYS55D, GLN31D, GLN37J, GLU197D, GLU32J, GLU44J, GLU48J, GLU58D, GLU60D, GLU60J, GLY16D, GLY205D, GLY213D, GLY38J, GLY49J, GLY53D, HIS14D, HIS198D, HIS200D, HIS23D, HIS45J, HIS54J, HIS57J, ILE26D, ILE42J, ILE46J, ILE55J, LEU17D, LEU18D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU21D, LEU51D, LEU51J, LYS184D, LYS202D, LYS207D, LYS50J, LYS53J, LYS56J, LYS58J, LYS62J, MET204D, MET208D, MET211D, MET212D, MET222D, PHE20J, PHE31J, PHE35J, SER13D, SER19D, SER20D, SER25D, THR188D, THR24D, THR57D, TRP12D, TRP52J, TYR43J, TYR56D, TYR59J, VAL52D, VAL54D
• D-d: ASN97D, ASN97d, GLU76D, GLU99d, GLY78D, GLY78d
• E-F: ARG71F, GLN73F, TYR13E
• E-G: ALA25G, ALA31E, ARG14E, ARG15E, ARG24G, ARG32E, ASP12E, ASP4E, ASP9E, GLN23G, GLU17E, GLU22G, GLY34E, HIS28G, HIS2E, ILE14G, ILE5E, LEU18G, LEU19E, LEU38E, LYS32G, LYS33E, LYS6E, PHE10E, PHE21G, PHE26G, PHE35E, PRO16E, PRO20G, PRO27G, PRO8E, SER11E, SER17G, SER19G, SER25E, SER28E, SER29E, SER36E, THR15G, TYR13E, TYR16G, TYR37E, VAL18E, VAL39E, VAL7E
• E-J: ALA21J, ALA28J, ALA31E, ALA39J, ALA41E, ALA48E, ALA50E, ALA7J, ARG15E, ARG15J, ARG32E, ARG33J, ARG8J, ASN53E, ASP36J, GLN37J, GLU17E, GLU27E, GLU30E, GLU32J, GLY27J, GLY34E, GLY46E, ILE24J, LEU12J, LEU13J, LEU22J, LEU29J, LEU38E, LEU5J, LEU9J, LYS33E, LYS52E, PHE14J, PHE20J, PHE30J, PHE31J, PHE35E, PHE35J, PRO3J, SER11J, SER28E, SER29E, SER36E, THR23J, THR40E, THR42E, THR43E, THR44E, THR4J, THR6J, TYR10J, TYR37E, TYR49E, VAL25J, VAL26J, VAL39E, VAL45E, VAL47E
• E-c: ARG282c, ASP67E, HIS141E, HIS161E, LYS172c, LYS287c, PRO175E, THR264c, VAL145E
• F-G: ALA23F, ALA24F, ALA43G, ARG11G, ARG2G, ARG39G, ARG40G, ARG47G, ARG48F, ARG64F, ARG71F, ARG9G, ASN22F, ASN36G, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU39F, GLU52F, GLY25F, GLY33G, HIS12G, ILE14G, ILE47F, ILE74F, LEU29F, LEU46G, LEU68F, LEU75F, LYS28F, LYS32G, LYS44F, LYS63F, PHE60F, PRO35G, SER69F, THR15G, THR8G, TRP19F, TRP80F, TYR20F, TYR55F, VAL10G, VAL13G, VAL37G, VAL59F
• F-a: ARG104F, HIS289a
• F-b: ARG104F, ARG133b, ARG134b, ARG49F, ARG87b, GLU100F, GLU103F, GLU136b, GLU96F, LYS110F, LYS84b
• G-H: ARG36H, ARG43H, ARG47H, ARG71G, ASN73G, ASP53H, ASP60H, CYS40H, CYS54H, GLU51H, GLU52H, GLU56H, GLU57H, GLU67G, HIS63H, LEU37H, LEU58H, LEU59H, LYS68G, LYS70G, LYS72G, THR55H, VAL44H
• G-J: PHE21G, TYR10J
• H-J: LYS58J, LYS78H
• K-a: ASN16K, THR347a
• L-M: ALA122L, ALA133L, ALA137L, ALA164M, ALA174M, ALA223L, ALA276L, ALA2M, ALA303L, ALA308L, ALA313L, ALA325L, ALA341L, ALA359L, ALA446L, ALA58M, ALA70M, ALA77M, ARG134M, ARG178M, ARG302L, ARG438L, ARG439L, ARG82M, ASN180M, ASN203M, ASN331L, ASN360L, ASN55L, ASP158M, ASP173M, ASP221L, ASP227L, ASP25M, ASP298L, ASP300L, ASP364L, ASP369L, ASP442L, ASP445L, ASP50L, ASP51L, ASP57M, ASP88M, CYS196M, CYS200M, GLN103M, GLN10M, GLN181M, GLN195M, GLN232L, GLN43L, GLN52L, GLN59M, GLN6M, GLU132M, GLU137M, GLU157M, GLU198M, GLU19M, GLU266L, GLU40L, GLU60M, GLU62M, GLU89M, GLY123L, GLY125L, GLY134L, GLY169M, GLY177M, GLY194M, GLY201M, GLY226L, GLY263L, GLY269L, GLY272L, GLY296L, GLY317L, GLY329L, GLY330L, GLY343L, GLY352L, GLY355L, GLY432L, GLY435L, GLY45L, GLY49L, GLY8M, HIS138L, HIS161M, HIS204M, HIS22M, HIS233L, HIS24M, HIS26M, HIS291L, HIS328L, HIS368L, HIS429L, HIS52M, ILE16M, ILE175M, ILE199M, ILE209M, ILE229L, ILE30M, ILE311L, ILE312L, ILE314L, ILE332L, ILE345L, ILE34M, ILE356L, ILE365L, ILE41M, ILE42M, ILE453L, ILE53L, ILE64M, ILE67M, ILE71M, ILE72M, ILE74M, ILE76M, ILE83M, LEU128M, LEU132L, LEU133M, LEU135M, LEU136L, LEU136M, LEU160M, LEU168M, LEU170M, LEU179M, LEU20M, LEU21M, LEU230L, LEU28M, LEU324L, LEU327L, LEU33M, LEU342L, LEU347L, LEU353L, LEU358L, LEU363L, LEU367L, LEU37M, LEU39M, LEU41L, LEU431L, LEU433L, LEU44M, LEU46M, LEU487L, LEU50M, LEU68M, LEU73M, LEU75M, LEU78M, LEU7M, LEU81M, LEU84M, LYS171M, LYS264L, LYS265L, LYS319L, LYS333L, LYS49M, MET122M, MET17M, MET1M, MET207M, MET271L, MET273L, MET292L, MET297L, MET310L, MET338L, MET339L, MET436L, MET449L, MET45M, MET56M, MET5M, MET86M, MET87M, PHE206M, PHE220L, PHE23M, PHE268L, PHE293L, PHE305L, PHE321L, PHE32M, PHE344L, PHE346L, PHE348L, PHE418L, PHE426L, PHE430L, PHE9M, PRO130L, PRO131L, PRO166M, PRO176M, PRO208M, PRO222L, PRO228L, PRO267L, PRO315L, PRO427L, PRO437L, PRO444L, PRO44L, PRO4M, PRO69M, PRO79M, SER156M, SER162M, SER167M, SER197M, SER202M, SER205M, SER262L, SER307L, SER322L, SER35M, SER361L, SER362L, SER36M, SER434L, SER43M, SER441L, SER54M, SER80M, THR124L, THR125M, THR127L, THR172M, THR182M, THR27M, THR294L, THR301L, THR306L, THR309L, THR316L, THR326L, THR349L, THR354L, THR370L, THR448L, THR46L, THR47M, THR48M, THR51M, THR53M, THR55M, THR59L, THR63M, THR66M, TRP104M, TRP106M, TRP126L, TRP163M, TRP275L, TRP323L, TRP334L, TRP450L, TRP65M, TYR129L, TYR193M, TYR231L, TYR270L, TYR304L, TYR372L, TYR3M, TYR40M, TYR440L, TYR443L, TYR447L, TYR54L, TYR85M, VAL128L, VAL159M, VAL165M, VAL258L, VAL295L, VAL299L, VAL318L, VAL31M, VAL320L, VAL350L, VAL357L, VAL366L, VAL38M, VAL56L, VAL58L, VAL61M
• L-N: ALA100N, ALA107N, ALA114L, ALA139L, ALA141L, ALA153L, ALA161L, ALA192L, ALA200N, ALA203L, ALA204L, ALA21N, ALA223L, ALA24N, ALA289L, ALA74N, ALA7N, ALA89L, ALA93L, ARG213L, ARG59N, ARG5L, ARG63N, ARG80N, ARG96L, ASN11L, ASN12N, ASN135L, ASN163L, ASN170L, ASN214L, ASN216L, ASN496L, ASN4L, ASN50N, ASN98L, ASN99L, ASP144L, ASP190N, ASP212L, ASP221L, ASP227L, ASP60N, ASP91L, GLN232L, GLN4N, GLN56N, GLN76N, GLU111N, GLU119L, GLU506L, GLU507L, GLU64N, GLU90N, GLY113N, GLY114N, GLY140L, GLY191N, GLY194N, GLY205L, GLY20N, GLY224L, GLY225L, GLY226L, GLY30N, GLY78N, GLY82N, GLY88L, GLY96N, HIS103N, HIS12L, HIS138L, HIS151L, HIS233L, HIS36N, HIS3N, HIS503L, HIS6N, HIS71N, HIS9N, ILE147L, ILE158L, ILE15L, ILE162L, ILE165L, ILE169L, ILE188N, ILE206L, ILE229L, ILE256N, ILE3L, ILE62N, ILE84N, ILE87N, ILE88N, LEU104L, LEU105L, LEU110L, LEU111L, LEU112N, LEU145L, LEU150L, LEU152L, LEU159L, LEU18N, LEU194L, LEU195L, LEU196L, LEU197L, LEU199L, LEU202L, LEU209L, LEU210L, LEU215L, LEU22N, LEU230L, LEU234L, LEU25N, LEU26N, LEU31N, LEU43N, LEU79N, LEU7L, LEU85N, LEU92N, LYS13L, LYS172L, LYS77N, MET100L, MET10N, MET171L, MET189L, MET1L, MET1N, MET208L, MET27N, MET292L, MET297L, MET33N, MET54N, MET83N, MET92L, MET97L, PHE101N, PHE102L, PHE109L, PHE148L, PHE164L, PHE197N, PHE198N, PHE203N, PHE219L, PHE220L, PHE233N, PHE237L, PHE238L, PHE285L, PHE305L, PHE35N, PHE37N, PHE505L, PHE86N, PHE8L, PHE93N, PHE94L, PHE94N, PHE97N, PHE98N, PRO106L, PRO107L, PRO108N, PRO110N, PRO118N, PRO13N, PRO15N, PRO173L, PRO174L, PRO17N, PRO200L, PRO222L, PRO228L, PRO501L, PRO508L, PRO73N, PRO90L, PRO95L, SER101L, SER104N, SER108L, SER115L, SER142L, SER149L, SER14N, SER156L, SER189N, SER195N, SER198L, SER23N, SER29N, SER65N, SER89N, SER9L, THR109N, THR10L, THR146L, THR166L, THR167L, THR187N, THR196N, THR19N, THR207L, THR211L, THR217L, THR218L, THR28N, THR2N, THR32N, THR504L, THR509L, THR53N, THR5N, THR95N, TRP103L, TRP116N, TRP16N, TRP236L, TRP288L, TRP34N, TRP57N, TRP58N, TRP6L, TRP99N, TYR102N, TYR193N, TYR231L, TYR502L, TYR81N, TYR8N, VAL118L, VAL11N, VAL143L, VAL155L, VAL192N, VAL193L, VAL199N, VAL201L, VAL61N, VAL75N, VAL91N
• L-O: ALA12O, ALA39L, ALA410L, ALA415L, ALA446L, ALA464L, ALA84O, ALA85O, ALA93O, ARG19O, ARG20O, ARG38L, ASN331L, ASN406L, ASN451L, ASN496L, ASN72O, ASP10O, ASP18O, ASP21O, ASP26O, ASP407L, ASP442L, ASP445L, ASP486L, CYS498L, GLN119O, GLN43L, GLU112O, GLU40L, GLU481L, GLU77O, GLU99O, GLU9O, GLY105O, GLY263L, GLY329L, GLY330L, GLY420L, GLY42L, GLY457L, GLY45L, GLY497L, GLY83O, GLY90O, HIS109O, HIS413L, ILE107O, ILE332L, ILE37L, ILE412L, ILE416L, ILE453L, ILE460L, ILE471L, ILE89O, ILE97O, LEU13O, LEU35L, LEU36L, LEU41L, LEU462L, LEU467L, LEU47L, LEU483L, LEU487L, LEU48L, LEU495L, LEU94O, LEU95O, LEU96O, LYS100O, LYS264L, LYS265L, LYS333L, LYS411L, LYS79O, LYS7O, MET123O, MET339L, MET417L, MET423L, MET449L, MET456L, MET466L, MET71O, MET86O, PHE111O, PHE414L, PHE418L, PHE459L, PHE470L, PHE87O, PHE88O, PHE91O, PRO106O, PRO108O, PRO14O, PRO336L, PRO444L, PRO44L, PRO499L, PRO500L, PRO501L, SER15O, SER262L, SER335L, SER455L, SER458L, SER461L, SER8O, THR110O, THR259L, THR408L, THR448L, THR452L, THR463L, THR46L, THR484L, THR488L, THR489L, THR504L, THR75O, THR80O, THR92O, TRP115O, TRP334L, TRP409L, TRP494L, TRP78O, TRP98O, TYR102O, TYR104O, TYR11O, TYR16O, TYR22O, TYR260L, TYR261L, TYR443L, TYR447L, VAL103O, VAL116O, VAL17O, VAL419L, VAL482L, VAL485L, VAL5O, VAL6O, VAL81O, VAL82O
• L-P: ASN331L, ASN34P, ASP40P, ASP73P, GLY329L, GLY38P, HIS328L, LYS264L, LYS265L, LYS31P, LYS74P, THR35P, VAL37P
• L-Q: ALA175L, ALA35Q, ALA38Q, ARG56Q, ASN32Q, ASN47Q, ASN491L, ASN496L, ASN512L, ASN54Q, ASN66Q, ASP29Q, ASP65Q, CYS60Q, CYS62Q, CYS82Q, CYS85Q, GLN178L, GLN180L, GLU266L, GLU493L, GLU506L, GLU507L, GLU63Q, GLU64Q, GLY41Q, GLY497L, GLY59Q, GLY88L, HIS88Q, HIS94Q, ILE33Q, ILE52Q, ILE57Q, ILE61Q, ILE70Q, ILE87L, LEU183L, LEU34Q, LEU487L, LEU48Q, LEU492L, LEU495L, LEU513L, LEU74Q, LEU91Q, LYS172L, LYS264L, LYS265L, LYS37Q, LYS514L, LYS55Q, LYS90Q, MET176L, MET271L, MET86L, PHE505L, PHE72Q, PRO173L, PRO174L, PRO182L, PRO267L, PRO30Q, PRO36Q, PRO501L, PRO508L, PRO50Q, PRO83Q, SER177L, SER51Q, SER67Q, SER84Q, THR181L, THR259L, THR39Q, THR488L, THR489L, THR490L, THR504L, THR509L, THR53Q, THR68Q, THR87Q, TRP186L, TRP494L, TRP71Q, TRP73Q, TYR179L, TYR270L, TYR31Q, TYR510L, TYR89Q, VAL274L, VAL49Q, VAL511L, VAL58Q, VAL69Q
• L-R: ALA139L, ALA141L, ALA223L, ARG213L, ARG54R, ARG56R, ASN135L, ASN214L, ASN216L, ASN66R, ASP144L, ASP212L, ASP221L, GLY140L, GLY224L, GLY225L, GLY226L, GLY65R, HIS51R, HIS52R, HIS67R, ILE55R, LEU136L, LEU210L, LEU215L, LEU53R, LYS58R, PHE60R, PHE69R, PRO222L, PRO59R, PRO79R, SER61R, THR211L, THR217L, THR218L, THR57R, THR68R, TRP62R
• L-S: ALA223L, ARG302L, ARG75S, ASN22S, ASN24S, ASP298L, ASP300L, GLN23S, GLN25S, GLY296L, ILE365L, MET292L, MET297L, PHE293L, PRO21S, PRO222L, THR26S, THR294L, THR301L, TRP68S, VAL295L, VAL299L
• L-T: ALA14T, ALA325L, ARG15T, ARG16T, ARG18T, ARG43T, GLY329L, GLY330L, HIS328L, ILE21T, LEU13T, LEU17T, LEU324L, LEU327L, LEU433L, LYS264L, PHE321L, TYR35T
• L-U: ALA114L, ALA141L, ALA53U, ARG96L, ASN4L, CYS49U, GLU119L, GLY51U, HIS21U, ILE3L, LEU110L, LEU111L, LEU113L, LEU145L, LEU22U, LEU40U, LEU47U, LEU50U, LEU7L, MET117L, MET36U, PHE55U, PHE8L, PRO107L, PRO19U, PRO56U, SER115L, SER116L, SER46U, SER54U, THR43U, TRP52U, TYR32U, VAL118L, VAL20U
• L-V: ALA33V, ALA446L, ASN406L, ASN41V, ASN451L, ASP407L, ASP445L, GLN43L, GLU39V, GLY37V, GLY420L, GLY42L, GLY457L, HIS10V, ILE36V, ILE38V, ILE412L, ILE453L, ILE460L, LYS411L, MET32V, MET423L, MET449L, MET456L, PHE459L, PHE9V, PRO42V, PRO444L, PRO44L, PRO44V, SER43V, SER454L, SER455L, SER458L, THR408L, THR448L, THR452L, TRP29V, TRP409L, TRP40V, TRP450L, TYR443L, TYR447L, VAL17V, VAL419L
• L-W: ALA114L, ALA120L, ALA122L, ALA23W, ALA24L, ALA26L, ALA32L, ALA34W, ALA35W, ALA39L, ALA475L, ALA477L, ALA60L, ARG20W, ARG41W, ARG480L, ARG5L, ASN10W, ASN11L, ASN17W, ASN4L, ASP14L, ASP50L, CYS498L, GLN43W, GLN52L, GLU119L, GLU16W, GLU474L, GLU481L, GLU4W, GLU506L, GLU5W, GLY121L, GLY23L, GLY27L, GLY30L, GLY30W, GLY32W, GLY402L, GLY49L, GLY6W, GLY8W, HIS2W, HIS42W, HIS503L, HIS61L, ILE11W, ILE39W, ILE3L, ILE471L, ILE472L, ILE53L, LEU112L, LEU113L, LEU18L, LEU20L, LEU21L, LEU21W, LEU22W, LEU27W, LEU33L, LEU35L, LEU36L, LEU399L, LEU44W, LEU45W, LEU462L, LEU47L, LEU48L, LEU7L, LYS13L, LYS18W, LYS46W, LYS479L, LYS9W, MET117L, MET1L, MET24W, MET25W, MET28L, MET466L, MET468L, PHE109L, PHE13W, PHE22L, PHE28W, PHE29W, PHE2L, PHE33W, PHE37W, PHE38W, PHE393L, PHE397L, PHE400L, PHE459L, PHE470L, PHE476L, PHE8L, PRO12W, PRO36W, PRO398L, PRO499L, PRO500L, PRO501L, PRO7W, SER115L, SER116L, SER142L, SER14W, SER1W, SER31W, SER34L, SER401L, SER478L, SER9L, THR10L, THR17L, THR26W, THR31L, THR504L, TRP19W, TRP25L, TRP473L, TRP6L, TRP81L, TYR19L, TYR3W, TYR403L, TYR502L, TYR54L, VAL118L, VAL15W, VAL29L, VAL40W, VAL465L, VAL469L, VAL482L, VAL56L, VAL57L, VAL64L
• L-X: ALA16X, ALA30X, ALA32L, ALA39L, ALA3X, ALA464L, ALA475L, ALA477L, ALA6X, ARG480L, ASN406L, ASP38X, ASP407L, ASP486L, CYS498L, GLN15X, GLU14X, GLU40L, GLU474L, GLU481L, GLY18X, GLY27L, GLY402L, GLY49L, HIS395L, ILE17X, ILE1X, ILE412L, ILE416L, ILE471L, ILE472L, ILE53L, LEU19X, LEU24X, LEU27X, LEU34X, LEU35L, LEU36L, LEU37X, LEU399L, LEU405L, LEU462L, LEU467L, LEU47L, LEU483L, LEU48L, LYS13X, LYS333L, LYS41X, LYS479L, LYS4X, LYS7X, MET28L, MET466L, MET468L, PHE23X, PHE26X, PHE459L, PHE470L, PHE476L, PRO12X, PRO336L, PRO398L, PRO5X, PRO9X, SER11X, SER20X, SER25X, SER335L, SER478L, THR10X, THR22X, THR2X, THR31L, THR404L, THR463L, THR46L, THR484L, THR8X, TRP409L, TRP473L, TRP494L, TYR260L, TYR261L, TYR403L, TYR40X, VAL21X, VAL29L, VAL33X, VAL465L, VAL469L, VAL482L, VAL485L
• M-N: ARG178M, GLU111N, GLY177M, HIS103N, LEU179M, PRO110N, PRO176M, THR109N
• M-O: ALA117O, ALA129O, ALA12M, ALA136O, ALA2M, ARG122O, ARG134M, ARG141M, ARG188M, ARG19O, ARG20O, ARG73O, ASN72O, ASP11M, ASP125O, ASP21O, ASP25M, GLN10M, GLN119O, GLN132O, GLN6M, GLU114O, GLU127M, GLU132M, GLU137M, GLU18M, GLU212M, GLY131M, GLY133O, GLY190M, HIS109O, HIS22M, HIS52M, ILE107O, ILE123M, ILE131O, LEU128M, LEU133M, LEU135M, LEU136M, LEU191M, LEU211M, LEU21M, LEU50M, LEU7M, LYS118O, LYS121O, LYS127O, LYS129M, LYS137O, LYS49M, MET123O, MET126O, MET1M, MET71O, PHE111O, PHE134O, PHE68O, PHE9M, PRO108O, PRO124M, PRO130M, PRO130O, PRO189M, PRO4M, SER126M, SER135O, SER167M, SER187M, SER54M, SER74O, THR110O, THR120O, THR125M, THR13M, THR48M, THR51M, THR53M, TRP115O, TRP145O, TYR192M, TYR193M, TYR3M, VAL116O, VAL128O, VAL138M, VAL210M
• M-P: ALA75P, ASN34P, ASP40P, ASP57M, ASP73P, GLY38P, GLY76P, HIS52M, HIS5P, HIS78P, ILE81P, LEU36P, LEU41P, LEU50M, LYS49M, LYS72P, LYS74P, MET56M, PRO77P, SER54M, THR35P, THR47M, THR48M, THR51M, THR53M, THR55M, TYR39P, VAL37P, VAL42P
• M-Q: ASN66Q, THR55M
• M-S: ALA14S, ARG151M, ARG178M, ARG27S, ARG57S, ARG58S, ASN180M, ASN22S, ASN24S, ASN28S, ASN91M, ASN92M, ASP112M, ASP115M, ASP173M, ASP17S, ASP88M, CYS29S, CYS64S, GLN12S, GLN181M, GLN23S, GLN25S, GLU109M, GLU114M, GLU157M, GLU89M, GLY177M, HIS102M, ILE150M, ILE175M, ILE66S, ILE90M, LEU116M, LEU153M, LEU179M, LEU216M, LEU63S, LEU84M, LEU95M, LYS171M, LYS61S, LYS98M, MET100M, MET148M, MET152M, MET87M, PHE16S, PHE20S, PRO15S, PRO176M, PRO21S, PRO65S, PRO93M, SER107M, SER117M, SER155M, SER156M, SER18S, SER62S, SER67S, SER94M, THR111M, THR13S, THR149M, THR172M, THR182M, THR183M, THR26S, THR96M, THR99M, TRP30S, TRP68S, TRP72S, TYR108M, TYR110M, TYR113M, TYR11S, TYR60S, VAL154M, VAL59S, VAL69S, VAL97M
• M-T: ALA12M, ALA14T, ALA24T, ALA32T, ALA40T, ALA46T, ALA48T, ALA72T, ARG141M, ARG15T, ARG16T, ARG188M, ARG18T, ARG43T, ARG64T, ASN140M, ASP11M, ASP139M, ASP25M, ASP55T, ASP59T, GLN10M, GLN70T, GLU132M, GLU137M, GLU147M, GLU18M, GLU19M, GLU212M, GLU220M, GLU41T, GLU61T, GLU62T, GLY11T, GLY190M, GLY23T, GLY30T, GLY67T, GLY8M, HIS20T, HIS22M, HIS24M, HIS26M, HIS52M, ILE123M, ILE21T, ILE30M, ILE34M, ILE41M, ILE64M, ILE68T, ILE72M, LEU12T, LEU13T, LEU144M, LEU17T, LEU191M, LEU20M, LEU211M, LEU213M, LEU216M, LEU21M, LEU28M, LEU29T, LEU33M, LEU37M, LEU39M, LEU44M, LEU46M, LEU50M, LEU68M, LYS217M, LYS221M, LYS36T, LYS42T, LYS44T, LYS45T, LYS49M, LYS58T, LYS73T, MET146M, MET17M, MET226M, MET26T, MET29M, MET45M, MET56M, MET57T, MET63T, MET9T, PHE118M, PHE19T, PHE219M, PHE23M, PHE25T, PHE31T, PHE32M, PHE34T, PHE37T, PHE50T, PHE60T, PHE69T, PHE9M, PRO15M, PRO189M, PRO215M, SER14M, SER186M, SER187M, SER223M, SER225M, SER28T, SER35M, SER36M, SER43M, SER56T, SER71T, THR13M, THR27M, THR33T, THR47M, THR48M, THR51M, THR53M, TRP222M, TRP65M, TYR192M, TYR193M, TYR218M, TYR35T, TYR40M, TYR47T, TYR51T, TYR54T, VAL138M, VAL142M, VAL143M, VAL210M, VAL214M, VAL22T, VAL27T, VAL31M, VAL38M, VAL39T, VAL61M
• M-V: ARG141M, ARG47V, ARG54V, ASN41V, GLN6M, GLU132M, GLU52V, GLY131M, LEU191M, LYS129M, LYS51V, MET5M, PRO130M, PRO42V, PRO44V, PRO4M, SER43V, TRP40V, TRP53V, TYR3M, VAL45V
• N-O: MET1N, TYR11O
• N-Q: ALA13Q, ALA1Q, ALA24Q, ALA74N, ALA7N, ALA97Q, ARG156N, ARG18Q, ARG221N, ARG56Q, ARG63N, ASN230N, ASN32Q, ASN54Q, ASP155N, ASP29Q, ASP9Q, GLN12Q, GLN222N, GLN4N, GLN68N, GLN76N, GLU10Q, GLU11Q, GLU153N, GLU17Q, GLU19Q, GLU64N, GLY154N, GLY15Q, GLY3Q, GLY4Q, GLY5Q, GLY69N, HIS158N, HIS226N, HIS231N, HIS232N, HIS3N, HIS6N, HIS70N, HIS71N, HIS94Q, HIS98Q, HIS9N, ILE33Q, ILE52Q, ILE57Q, LEU151N, LEU160N, LEU16Q, LEU96Q, LYS157N, LYS224N, LYS55Q, MET10N, MET152N, MET159N, MET1N, MET21Q, PHE225N, PHE227N, PHE67N, PRO30Q, PRO50Q, PRO73N, PRO7Q, SER150N, SER229N, SER2Q, SER51Q, SER65N, THR14Q, THR228N, THR2N, THR53Q, THR5N, THR66N, THR72N, THR8Q, TRP146N, TRP73Q, TYR31Q, TYR8N, VAL20Q, VAL6Q, VAL75N
• N-R: ALA139N, ALA13R, ALA147N, ALA162N, ALA178N, ALA184N, ALA1R, ALA24R, ALA29R, ALA46R, ARG14R, ARG17R, ARG42R, ARG44R, ARG54R, ARG56R, ARG74R, ASN125N, ASN133N, ASN34R, ASN38N, ASN66R, ASN72R, ASN76R, ASP155N, ASP190N, CYS115N, CYS31R, GLN161N, GLN177N, GLU111N, GLU128N, GLU153N, GLU180N, GLU183N, GLU43R, GLY113N, GLY120N, GLY12R, GLY141N, GLY191N, GLY194N, GLY22R, GLY40R, GLY63R, GLY65R, HIS122N, HIS148N, HIS149N, HIS158N, HIS243N, HIS36N, HIS38R, HIS41R, HIS51R, HIS52R, HIS67R, HIS71R, ILE121N, ILE144N, ILE165N, ILE188N, ILE48R, ILE55R, LEU112N, LEU124N, LEU127N, LEU131N, LEU132N, LEU137N, LEU138N, LEU151N, LEU169N, LEU176N, LEU19R, LEU23R, LEU25R, LEU30R, LEU31N, LEU33R, LEU37R, LEU43N, LEU53R, LEU78R, LYS157N, LYS58R, MET152N, MET159N, MET33N, MET40N, PHE186N, PHE18R, PHE198N, PHE21R, PHE35N, PHE37N, PHE47R, PHE60R, PHE69R, PHE70R, PRO110N, PRO117N, PRO118N, PRO123N, PRO126N, PRO130N, PRO185N, PRO26R, PRO45R, PRO59R, PRO73R, PRO77R, PRO79R, SER135N, SER140N, SER143N, SER150N, SER179N, SER189N, SER195N, SER27R, SER35R, SER39N, SER39R, SER61R, THR109N, THR119N, THR11R, THR134N, THR145N, THR15R, THR166N, THR168N, THR187N, THR20R, THR32N, THR32R, THR57R, THR68R, TRP146N, TRP16R, TRP258N, TRP34N, TRP36R, TRP62R, TYR172N, TYR181N, TYR182N, TYR193N, TYR50R, TYR82R, VAL129N, VAL136N, VAL142N, VAL192N, VAL28R, VAL75R
• N-S: ALA107N, ARG27S, ARG38S, ARG75S, ASN24S, CYS115N, CYS29S, GLN31S, GLU111N, GLY113N, GLY114N, GLY120N, GLY83S, LEU112N, LEU34S, LYS84S, PHE81S, PRO108N, PRO110N, PRO118N, PRO82S, THR109N, THR119N, THR26S, THR80S, TRP116N, TRP30S, TRP68S, TRP72S, TYR33S
• N-U: ALA21N, ALA24N, ALA53U, ALA6U, ARG156N, ARG221N, ARG33U, ARG4U, ARG59N, ARG63N, ASN12N, ASN16U, ASN29U, ASN3U, ASN50N, ASP28U, ASP60N, CYS39U, CYS49U, GLN13U, GLN222N, GLN56N, GLN68N, GLN9U, GLU14U, GLU2U, GLU64N, GLU7U, GLY17U, GLY20N, GLY24U, GLY25U, GLY30N, GLY41U, GLY42U, GLY46N, GLY69N, HIS21U, HIS226N, HIS36N, HIS70N, HIS9N, ILE30U, ILE45N, ILE62N, LEU11U, LEU160N, LEU18N, LEU18U, LEU223N, LEU22N, LEU22U, LEU25N, LEU26N, LEU31U, LEU38U, LEU40U, LEU42N, LEU43N, LEU44U, LEU47U, LEU50U, LEU52N, LYS10U, LYS224N, LYS23U, LYS8U, MET33N, MET36U, MET40N, MET44N, MET51N, MET54N, PHE12U, PHE1U, PHE220N, PHE225N, PHE227N, PHE37N, PHE55U, PHE67N, PRO13N, PRO15N, PRO19U, SER14N, SER23N, SER29N, SER39N, SER46U, SER54U, SER65N, THR19N, THR228N, THR27U, THR32N, THR35U, THR37U, THR41N, THR43U, THR48N, THR49N, THR53N, THR66N, TRP16N, TRP52U, TRP57N, TYR32U, TYR45U, TYR48U, TYR55N, VAL11N, VAL20U, VAL34U, VAL5U, VAL61N
• N-W: ASN12N, MET10N, PRO13N, SER1W, TYR3W
• O-P: ALA26P, ALA28O, ALA46O, ALA51P, ALA54P, ALA62P, ALA64P, ALA69O, ALA75P, ARG19O, ARG20O, ARG30P, ARG53P, ARG56P, ARG57P, ARG61O, ARG66P, ARG73O, ASN34P, ASN59P, ASN72O, ASN94P, ASP107P, ASP18O, ASP21O, ASP26O, ASP54O, ASP60P, ASP73P, CYS55P, GLU102P, GLU103P, GLU28P, GLU42O, GLU44O, GLU55O, GLU58O, GLU66O, GLU69P, GLU70O, GLU95P, GLY105P, GLY32P, GLY38P, GLY76P, GLY97P, HIS29O, ILE53O, ILE67P, ILE98P, LEU104P, LEU106P, LEU24O, LEU29P, LEU36P, LEU40O, LEU51O, LEU52P, LEU58P, LEU59O, LEU62O, LEU68P, LEU93P, LEU96P, LYS108P, LYS31P, LYS41O, LYS43O, LYS45O, LYS56O, LYS63O, LYS65O, LYS72P, LYS74P, MET33P, MET71O, PHE19P, PHE61P, PHE64O, PHE68O, PRO101P, PRO14O, PRO23O, PRO25O, PRO77P, SER47O, SER49O, SER50O, SER52O, SER63P, SER67O, SER74O, SER99P, THR100P, THR35P, THR92P, TRP27P, TRP48O, TYR16O, TYR22O, TYR60O, VAL109P, VAL17O, VAL27O, VAL37P, VAL57O, VAL65P, VAL70P, VAL71P
• O-Q: ALA12O, ARG56Q, ASN54Q, ASP10O, ASP26O, GLN80Q, GLU9O, HIS75Q, ILE57Q, LEU13O, LEU74Q, LYS55Q, PHE72Q, PRO14O, PRO83Q, SER84Q, TRP73Q, TYR11O, TYR22O
• O-T: ALA129O, ALA136O, ALA38T, ALA40T, ALA46T, ALA48T, ALA66T, ARG122O, ARG43T, ARG64T, ASP125O, ASP141O, ASP49T, ASP59T, GLN132O, GLN70T, GLU41T, GLU61T, GLU62T, GLY133O, GLY67T, ILE131O, ILE68T, LEU124O, LYS121O, LYS127O, LYS42T, LYS44T, LYS45T, LYS58T, MET123O, MET126O, MET63T, PHE50T, PHE60T, PHE69T, PRO130O, SER135O, TYR140O, TYR47T, TYR51T, TYR54T, VAL128O, VAL39T
• O-V: ALA117O, ALA136O, ALA16V, ALA19V, ALA22V, ALA27V, ALA33V, ALA84O, ALA85O, ALA93O, ARG122O, ARG47V, ARG54V, ARG73O, ASN143O, ASN15V, ASN41V, ASN76O, ASP11V, ASP125O, ASP8V, CYS25V, GLN119O, GLN35V, GLU112O, GLU113O, GLU114O, GLU144O, GLU39V, GLU52V, GLU77O, GLU99O, GLY133O, GLY14V, GLY21V, GLY37V, GLY46V, GLY83O, GLY90O, HIS101O, HIS10V, ILE107O, ILE36V, ILE38V, ILE89O, ILE97O, LEU124O, LEU18V, LEU94O, LEU95O, LEU96O, LYS100O, LYS118O, LYS121O, LYS12V, LYS137O, LYS146O, LYS147O, LYS51V, LYS79O, MET123O, MET126O, MET32V, MET86O, PHE111O, PHE134O, PHE24V, PHE87O, PHE88O, PHE91O, PHE9V, PRO106O, PRO108O, PRO42V, PRO44V, PRO50V, PRO7V, SER135O, SER20V, SER43V, SER74O, THR110O, THR120O, THR23V, THR34V, THR49V, THR75O, THR80O, THR92O, TRP115O, TRP138O, TRP145O, TRP29V, TRP40V, TRP53V, TRP78O, TRP98O, TYR104O, TYR13V, TYR31V, VAL116O, VAL17V, VAL26V, VAL28V, VAL30V, VAL45V, VAL48V, VAL81O, VAL82O
• O-W: LEU95O, PHE33W, PHE37W, PRO7W, SER8O, VAL103O
• O-X: ALA16X, ALA30X, ALA3X, ASP18O, ASP38X, GLU99O, GLU9O, GLY105O, GLY31X, HIS101O, HIS36X, ILE1X, LEU19X, LEU24X, LEU27X, LEU28X, LEU34X, LEU37X, LEU94O, LEU95O, LYS41X, LYS4X, LYS65O, LYS7O, LYS7X, PHE23X, PHE26X, PHE87O, PHE88O, PHE91O, PRO5X, SER15O, SER20X, SER8O, THR2X, THR92O, TRP32X, TRP98O, TYR102O, TYR104O, TYR16O, TYR35X, VAL103O, VAL17O, VAL33X, VAL5O, VAL6O
• P-Q: ARG30P, ARG81Q, ASN34P, ASN66Q, ASP23P, ASP25P, ASP65Q, CYS82Q, CYS85Q, GLN80Q, GLU28P, GLU63Q, GLU64Q, GLY86Q, HIS2P, HIS88Q, LEU29P, LYS21P, LYS31P, LYS43Q, PRO83Q, SER1P, SER84Q, THR35P, THR87Q, TRP27P, TYR18P
• P-T: ALA13P, ALA14T, ALA3T, ALA5T, ALA75P, ARG10T, ARG15T, ARG16T, ARG18T, ASP12P, ASP40P, ASP8P, GLN87P, GLN8T, GLU10P, GLU44P, GLU6P, GLU80P, GLU88P, GLU9P, GLY11T, GLY76P, HIS78P, ILE47P, ILE48P, ILE81P, ILE86P, LEU12T, LEU13T, LEU17T, LEU36P, LEU41P, LEU4T, LYS46P, LYS6T, LYS74P, LYS79P, MET9T, PHE11P, PRO43P, PRO45P, PRO77P, PRO7T, PRO83P, THR2T, THR7P, TRP15P, TYR39P, TYR82P, TYR84P, VAL42P, VAL71P, VAL85P
• Q-R: ALA13R, ALA1Q, ARG14R, ARG17R, PHE18R, PHE21R, SER2Q, THR15R
• Q-U: ALA13Q, ALA6U, ARG18Q, ARG4U, ASN3U, GLN12Q, GLN13U, GLN9U, GLU11Q, GLU17Q, GLU19Q, GLY15Q, GLY5Q, LEU16Q, LYS10U, LYS8U, PHE12U, PRO7Q, THR14Q, VAL5U, VAL6Q
• R-S: ARG54R, ARG75S, ASP74S, GLU78S, GLY79S, GLY83S, HIS51R, HIS52R, ILE48R, LEU53R, LYS84S, PHE47R, PHE81S, PRO49R, PRO82S, THR71S, THR80S, TYR50R
• T-V: ALA66T, ARG54V, GLU52V, GLY67T, ILE68T, MET63T, PHE69T, TRP53V
• U-W: ALA53U, GLN43W, GLY51U, HIS42W, ILE39W, LEU45W, LEU50U, LYS46W, LYS47W, PHE55U, PRO56U, SER54U, TRP52U
• V-X: GLN15X, PHE9V, PRO12X, TYR13V
• W-X: ALA16X, ALA23W, ALA30X, ALA34W, ALA35W, ALA6X, ARG41W, ASN17W, ASN39X, ASP38X, GLN15X, GLN43W, GLU14X, GLU16W, GLY18X, GLY30W, GLY31X, GLY32W, HIS36X, HIS42W, ILE17X, ILE39W, LEU19X, LEU22W, LEU24X, LEU27W, LEU27X, LEU28X, LEU34X, LEU37X, LEU44W, LEU45W, LYS13X, LYS18W, LYS41X, LYS42X, LYS46W, LYS47W, LYS4X, LYS7X, MET25W, PHE23X, PHE26X, PHE28W, PHE29W, PHE33W, PHE37W, PHE38W, PRO12X, PRO29X, PRO36W, PRO7W, PRO9X, SER11X, SER20X, SER25X, SER31W, SER43X, THR10X, THR22X, THR26W, THR8X, TRP19W, TRP32X, TYR35X, TYR40X, VAL15W, VAL21X, VAL33X, VAL40W
• Y-d: ALA83Y, GLU145d, GLU167d, LYS25Y, LYS27Y, LYS86Y, LYS87Y, TYR165d
• a-b: ALA291b, ALA2a, ALA88a, ARG113b, ARG287b, ARG356a, ARG46b, ARG87b, ASN363a, ASP114b, ASP370a, CYS282a, GLN143b, GLU130a, GLU137a, GLU373b, GLU376b, GLU60a, GLU76a, GLU80a, GLU90b, HIS284b, HIS289a, HIS61a, HIS85a, LEU86a, LYS100a, LYS286b, LYS363b, LYS65a, SER289b, SER291a, SER375b, THR292b, THR372a, TYR4a, VAL92b
• a-c: ARG436a, ASN435a, ASP20c, ASP214c, ASP332a, ASP433a, GLU429a, HIS221c, LYS217c, TYR223c
• a-d: ARG238d, ARG438a, ASN435a, ASP433a, HIS243a, LYS226d
• a-e: ARG14e, ARG235a, ASP142a, ASP147a, ASP20e, ASP417a, ASP4e, GLU168a, GLU172a, GLU258a, GLU30e, GLU50a, HIS243a, HIS2e, LYS26e, LYS33e, LYS6e, SER171a, SER21e, VAL18e
• a-f: ARG244a, LYS63f
• a-g: ARG11g, ARG235a, ARG244a, ARG9g, ASP246a, CYS242a, GLN240a, GLU22g, GLU245a, GLU429a, GLY238a, GLY5g, HIS12g, HIS243a, HIS328a, HIS6g, LEU7g, SER17g, SER19g, THR15g, THR8g, VAL10g, VAL13g
• a-i: CYS51i, GLN136a, GLN305a, GLU130a, GLU137a, GLU140a, GLU53i, GLY285a, GLY286a, HIS61a, LEU50i, LEU70i, SER69i, VAL42i
• a-j: ARG15j, ASP417a, SER412a
• b-i: ALA59i, ALA66i, ARG287b, ARG52i, ARG56i, ASN290b, ASN313b, ASP308b, GLN153b, GLN156b, GLN276b, GLN58i, GLU53i, GLY288b, GLY57i, GLY61i, LEU70i, LEU96b, PRO41i, SER100b, VAL309b, VAL68i, VAL98b
• c-d: ARG118d, ARG120d, ARG233d, ARG49d, ARG71c, ARG80c, ASP216c, ASP248c, ASP252c, ASP254c, ASP72c, GLU195d, GLU197d, HIS121d, HIS221c, HIS267c, HIS50d, LYS223d, LYS226d, LYS227c, TYR115d
• c-e: ALA66e, ASP67e, ASP72c, HIS68c
• c-f: ARG17f, ARG313c, ARG33f, ASP214c, ASP216c, ASP34f, ASP67f, ASP86f, GLU39f, HIS308c, HIS38f, LYS311c, LYS375c, LYS378c, LYS63f
• c-g: ARG2g, ASP214c, GLU344c, GLU65g, HIS345c, LYS217c, LYS70g
• d-e: ARG238d, ARG49d, ASP4e, ASP67e, ASP80e, ASP9e, GLU76d, HIS2e, HIS50d, LYS234d, LYS77e, LYS86d, SER72e
• d-f: ARG233d, ARG71f, ASP67f, LYS231d, LYS234d
• d-g: ALA236d, ALA25g, ARG224d, ARG238d, ARG24g, ASP2d, GLN23g, GLU4d, HIS12g, ILE14g, LYS234d, LYS70g, SER232d, TYR16g
• d-h: ARG21h, ARG28d, ASP15h, ASP173d, ASP185d, ASP22d, CYS54h, GLN181d, HIS63h, HIS6d, LYS184d, LYS78h, SER180d, THR132d, THR139d
• d-j: ARG203d, ASN47j, ASP173d, ASP199d, ASP22d, ASP36j, ASP40j, ASP59d, GLU44j, GLU60d, GLU60j, HIS14d, HIS23d, HIS54j, LEU18d, LYS207d, LYS50j, LYS58j, LYS62j, SER13d, SER20d
• e-g: ARG14e, ARG15e, ARG24g, ARG32e, ASP12e, GLN23g, GLU17e, GLU22g, HIS28g, LYS32g, TYR13e
• e-j: ARG15j, ARG8j, GLU30e, GLU32j, LYS33e, LYS52e, SER11j, TYR10j
• f-g: ALA23f, ARG11g, ARG39g, ARG47g, ARG9g, ASP56f, ASP57f, GLN72f, GLU52f, HIS12g
• g-h: ARG36h, ARG71g, ASP60h, GLU56h, GLU57h, LYS70g, LYS72g