2Y9D

structure of the spliceosomal u4 snrnp core domain

• Total interactions analyzed: 276
• Total true interactions: 32
• Strongest Interaction:
  • Chains: Q-T
  • Int. Res.: 79
  • Norm. En. per Res.: -4.2415
• Hub Node: L(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-19.6029	-2.2114	-108.699	-130.5133	73	35	2	6653	0	17	18
A-C	0.0	0.0	-0.0559	-0.0559	2	0	0	15	0	0	1
A-D	-40.6882	-50.4147	-181.156	-272.2589	97	25	11	10272	9	27	28
B-C	-65.5002	30.8237	-339.464	-374.1405	106	64	10	15674	0	38	48
C-F	-38.2435	-40.4872	-43.2756	-122.0063	75	36	6	7269	1	8	10
D-E	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
D-G	-23.4477	14.6657	-125.145	-133.927	68	23	1	7018	0	20	13
E-F	-17.0304	-23.6926	-129.547	-170.2699	74	19	4	6778	1	22	18
E-G	-46.7021	-19.3519	-118.024	-184.078	80	36	10	9050	0	9	6
F-G	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
H-I	-39.8679	1.468	-117.597	-155.9969	82	34	1	6867	0	18	23
H-J	0.0	0.0	-0.013	-0.013	2	0	0	9	0	0	1
H-K	-32.8115	-20.9534	-188.908	-242.6729	97	11	10	10402	6	26	30
I-J	-54.8562	38.5517	-302.772	-319.0765	112	71	9	15755	3	41	53
I-M	0.0	0.0	-0.0035	-0.0035	5	0	0	6	0	0	2
J-M	-60.2944	-41.8712	-103.53	-205.6956	76	75	9	8942	2	11	10
K-N	-19.6666	-2.3558	-117.076	-139.0984	71	21	1	6431	0	18	14
L-M	-25.1671	-25.8692	-102.645	-153.6813	80	28	6	7900	1	29	20
L-N	-31.0244	-18.2037	-114.268	-163.4961	73	29	8	8253	0	8	7
L-S	-5.1705	0.0	-26.7572	-31.9277	33	3	2	2085	0	0	5
L-U	0.0	-5.8151	-0.1389	-5.9541	6	0	0	42	0	3	2
N-S	0.0	-26.7567	-24.9605	-51.7171	14	11	0	967	0	3	4
O-P	-67.6253	-0.2685	-133.86	-201.7538	74	30	2	7275	0	20	24
O-Q	0.0	0.0	-0.0306	-0.0306	2	0	0	11	0	0	1
O-R	-28.659	-0.8366	-178.868	-208.3636	100	34	13	11381	4	29	33
O-U	0.0	0.0	-0.0015	-0.0015	2	0	0	1	0	0	0
P-Q	-59.7266	21.9024	-277.47	-315.2942	102	71	9	14093	0	33	47
P-T	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	2
Q-T	-73.2396	-61.4291	-200.407	-335.0757	79	68	8	10343	3	10	10
R-U	-10.3495	5.5342	-106.691	-111.5063	61	17	1	5866	0	17	14
S-T	-30.1728	-41.2263	-179.076	-250.4751	81	17	4	8626	1	27	18
S-U	-37.038	-22.3792	-142.671	-202.0883	78	36	10	8520	2	9	8

Interface residues

• A-B: ARG118A, ARG149A, ARG173A, ARG250B, ARG261B, ASN176A, ASN221B, ASN237B, ASN263B, ASN264B, ASP123A, ASP233B, CYS119A, GLN111A, GLN122A, GLN254B, GLU175A, GLU183A, GLU256B, GLY124A, GLY174A, GLY231B, GLY262B, HIS112A, HIS137A, HIS239B, ILE120A, ILE126A, ILE151A, ILE217B, ILE229B, ILE260B, ILE265B, LEU121A, LEU140A, LEU177A, LEU219B, LEU240B, LEU247B, LEU255B, LEU258B, LYS108A, LYS136A, LYS150A, LYS220B, LYS241B, LYS248B, MET109A, MET117A, MET138A, MET180A, MET201B, MET245B, PHE131A, PHE134A, SER106A, SER107A, SER179A, SER211B, SER235B, SER259B, THR181A, THR223B, THR230B, THR238B, THR257B, VAL178A, VAL182A, VAL225B, VAL232B, VAL234B, VAL243B, VAL253B
• A-C: ARG347C, GLN122A
• A-D: ALA133A, ALA80D, ARG116A, ARG125A, ARG149A, ARG165A, ARG173A, ARG194A, ARG29D, ARG51D, ARG64D, ARG69D, ASN139A, ASN176A, ASN23D, ASN38D, ASN40D, ASN79D, ASN88D, ASN90D, ASP114A, ASP123A, ASP135A, ASP144A, ASP189A, ASP75D, CYS143A, CYS145A, CYS20D, GLN122A, GLN91D, GLU147A, GLU175A, GLU21D, GLY124A, GLY168A, GLY174A, GLY191A, GLY25D, GLY4D, GLY65D, HIS137A, ILE113A, ILE141A, ILE192A, ILE68D, ILE72D, ILE7D, LEU10D, LEU121A, LEU140A, LEU142A, LEU167A, LEU169A, LEU171A, LEU172A, LEU177A, LEU71D, LEU73D, LEU77D, LEU83D, LYS132A, LYS136A, LYS188A, LYS67D, LYS84D, LYS87D, MET138A, MET39D, MET76D, MET82D, MET86D, PHE127A, PHE131A, PHE134A, PHE70D, PRO186A, PRO187A, PRO6D, PRO74D, PRO81D, SER66D, SER85D, THR130A, THR190A, THR19D, THR22D, THR24D, THR49D, TYR115A, VAL166A, VAL170A, VAL178A, VAL195A, VAL27D, VAL5D, VAL9D
• B-C: ALA294B, ALA358C, ARG205B, ARG261B, ARG266B, ARG292B, ARG347C, ARG355C, ARG361C, ARG394C, ARG402C, ASN221B, ASN237B, ASN263B, ASN264B, ASN338C, ASN339C, ASN348C, ASN349C, ASN364C, ASN369C, ASP272B, ASP277B, ASP282B, ASP360C, ASP404C, CYS346C, CYS363C, GLN224B, GLN341C, GLU218B, GLU284B, GLU293B, GLU368C, GLU372C, GLY222B, GLY262B, GLY403C, HIS362C, ILE217B, ILE260B, ILE265B, ILE269B, ILE396C, ILE407C, LEU203B, LEU207B, LEU210B, LEU219B, LEU270B, LEU274B, LEU276B, LEU279B, LEU280B, LEU329C, LEU332C, LEU352C, LEU367C, LEU401C, LYS202B, LYS220B, LYS286B, LYS288B, LYS290B, LYS291B, LYS337C, LYS350C, LYS357C, LYS398C, MET201B, MET236B, MET365C, MET399C, PHE206B, PHE268B, PHE359C, PHE400C, PRO271B, PRO275B, PRO285B, SER235B, SER273B, SER289B, SER335C, SER397C, SER405C, THR216B, THR238B, THR278B, THR333C, THR340C, TRP374C, TYR267B, TYR395C, VAL204B, VAL215B, VAL232B, VAL234B, VAL283B, VAL287B, VAL295B, VAL336C, VAL356C, VAL366C, VAL370C, VAL406C
• C-F: ALA416C, ALA545F, ARG347C, ARG361C, ARG402C, ARG411C, ARG565F, ASN345C, ASN348C, ASN349C, ASN364C, ASN412C, ASN541F, ASN546F, ASN567F, ASN568F, ASP360C, ASP404C, ASP537F, CYS346C, CYS363C, CYS566F, GLN334C, GLN543F, GLU549F, GLU561F, GLY327C, GLY403C, GLY417C, GLY538F, GLY557F, GLY560F, HIS362C, HIS558F, ILE344C, ILE407C, ILE551F, ILE564F, LEU332C, LEU343C, LEU410C, LEU414C, LEU523F, LEU544F, LEU559F, LEU563F, LYS350C, LYS351C, LYS418C, LYS524F, MET365C, MET527F, MET540F, PRO328C, PRO413C, SER330C, SER335C, SER405C, SER535F, SER556F, THR326C, THR340C, THR547F, TRP525F, TYR529F, TYR539F, VAL331C, VAL342C, VAL406C, VAL408C, VAL409C, VAL534F, VAL536F, VAL562F, VAL569F
• D-E: GLN638E, LYS67D
• D-G: ALA35D, ALA56D, ALA704G, ALA772G, ARG64D, ARG763G, ARG775G, ASN23D, ASN38D, ASN40D, ASN722G, ASN739G, ASN765G, ASP37D, CYS20D, CYS41D, GLN42D, GLN57D, GLN60D, GLU26D, GLU34D, GLU36D, GLU59D, GLU708G, GLU771G, GLU774G, GLY65D, GLY724G, GLY764G, HIS705G, HIS726G, ILE33D, ILE46D, ILE63D, ILE68D, ILE767G, ILE768G, LEU58D, LEU709G, LEU717G, LEU719G, LEU721G, LEU740G, LEU770G, LEU773G, LYS67D, LYS711G, LYS720G, MET43D, MET738G, MET769G, PHE712G, PHE734G, PHE737G, PRO707G, PRO736G, SER66D, SER718G, SER766G, THR22D, THR24D, TYR28D, TYR50D, TYR62D, VAL27D, VAL48D, VAL61D, VAL776G
• E-F: ALA661E, ARG573F, ARG671E, ARG676E, ASN506F, ASN512F, ASN541F, ASN567F, ASN568F, ASN640E, ASN655E, ASN683E, ASP651E, ASP659E, ASP682E, CYS566F, GLN626E, GLN638E, GLN673E, GLU528F, GLU637E, GLU652E, GLU663E, GLY526F, GLY538F, GLY574F, GLY649E, GLY675E, GLY681E, HIS665E, ILE572F, ILE643E, ILE648E, ILE677E, ILE684E, LEU511F, LEU514F, LEU523F, LEU533F, LEU570F, LEU635E, LEU656E, LEU658E, LEU674E, LEU679E, LYS508F, LYS517F, LYS522F, LYS524F, LYS672E, LYS680E, MET520F, MET540F, MET542F, MET641E, MET678E, PHE510F, PHE622E, PHE650E, PRO507F, PRO509F, THR515F, THR685E, TRP525F, TYR539F, TYR550F, TYR571F, TYR653E, VAL519F, VAL521F, VAL536F, VAL569F, VAL639E, VAL657E
• E-G: ARG623E, ARG628E, ARG642E, ARG725G, ARG732G, ARG763G, ASN619E, ASN640E, ASN655E, ASN683E, ASN692E, ASN722G, ASN739G, ASN755G, ASN756G, ASN765G, ASP682E, ASP714G, ASP735G, CYS745G, GLN632E, GLN638E, GLN688E, GLU637E, GLU652E, GLU708G, GLU747G, GLY681E, GLY723G, GLY733G, GLY758G, GLY764G, HIS705G, ILE618E, ILE621E, ILE684E, ILE742G, ILE757G, ILE762G, ILE767G, LEU620E, LEU625E, LEU656E, LEU686E, LEU687E, LEU709G, LEU719G, LEU721G, LEU731G, LEU740G, LYS680E, LYS710G, LYS711G, MET654E, MET713G, MET738G, MET759G, PHE622E, PHE712G, PHE734G, PHE737G, PRO617E, PRO706G, PRO707G, PRO736G, SER689E, SER691E, SER766G, THR685E, TRP634E, TYR624E, TYR636E, TYR653E, VAL633E, VAL690E, VAL727G, VAL741G, VAL746G, VAL760G, VAL761G
• F-G: ASN722G, LYS524F
• H-I: ARG118H, ARG173H, ARG250I, ARG261I, ASN176H, ASN221I, ASN237I, ASN263I, ASN264I, ASP123H, ASP135H, ASP233I, CYS119H, GLN111H, GLN122H, GLN254I, GLU175H, GLU183H, GLU251I, GLU256I, GLY104H, GLY124H, GLY174H, GLY184H, GLY231I, GLY262I, HIS112H, HIS137H, HIS212I, HIS239I, ILE120H, ILE126H, ILE151H, ILE217I, ILE229I, ILE260I, ILE265I, LEU110H, LEU121H, LEU140H, LEU177H, LEU219I, LEU240I, LEU247I, LEU255I, LEU258I, LYS105H, LYS108H, LYS136H, LYS154H, LYS220I, LYS241I, MET109H, MET117H, MET138H, MET180H, MET208I, MET236I, MET245I, PHE131H, PHE134H, PRO185H, SER106H, SER107H, SER179H, SER211I, SER235I, SER259I, THR102H, THR181H, THR223I, THR230I, THR238I, THR257I, TYR115H, VAL178H, VAL182H, VAL225I, VAL232I, VAL234I, VAL243I, VAL253I
• H-J: ARG347J, GLN122H
• H-K: ALA133H, ALA193H, ALA80K, ARG116H, ARG125H, ARG149H, ARG165H, ARG173H, ARG194H, ARG29K, ARG51K, ARG64K, ARG69K, ASN139H, ASN176H, ASN23K, ASN38K, ASN40K, ASN79K, ASN88K, ASN90K, ASP114H, ASP123H, ASP135H, ASP144H, ASP75K, CYS143H, CYS145H, CYS20K, GLN122H, GLN91K, GLU147H, GLU175H, GLU21K, GLY124H, GLY168H, GLY174H, GLY191H, GLY25K, GLY4K, GLY65K, HIS137H, ILE113H, ILE141H, ILE192H, ILE68K, ILE72K, ILE7K, LEU10K, LEU121H, LEU140H, LEU142H, LEU167H, LEU169H, LEU171H, LEU172H, LEU177H, LEU71K, LEU73K, LEU77K, LEU83K, LYS132H, LYS136H, LYS188H, LYS67K, LYS78K, LYS84K, LYS87K, LYS89K, MET39K, MET76K, MET82K, MET86K, PHE127H, PHE131H, PHE134H, PHE70K, PRO186H, PRO187H, PRO6K, PRO74K, PRO81K, SER66K, SER85K, THR130H, THR190H, THR19K, THR22K, THR24K, THR49K, TYR115H, VAL166H, VAL170H, VAL195H, VAL27K, VAL5K, VAL9K
• I-J: ALA294I, ALA358J, ARG205I, ARG261I, ARG266I, ARG292I, ARG319J, ARG347J, ARG355J, ARG361J, ARG394J, ARG402J, ASN221I, ASN237I, ASN249I, ASN263I, ASN264I, ASN338J, ASN339J, ASN348J, ASN349J, ASN364J, ASN369J, ASP272I, ASP277I, ASP282I, ASP360J, ASP404J, CYS346J, CYS363J, GLN224I, GLU218I, GLU284I, GLU293I, GLU314J, GLU315J, GLU368J, GLU372J, GLY222I, GLY262I, GLY354J, GLY403J, HIS362J, ILE217I, ILE265I, ILE269I, ILE396J, ILE407J, LEU203I, LEU207I, LEU210I, LEU219I, LEU270I, LEU274I, LEU276I, LEU279I, LEU280I, LEU316J, LEU329J, LEU332J, LEU352J, LEU367J, LEU401J, LYS220I, LYS248I, LYS286I, LYS288I, LYS290I, LYS291I, LYS318J, LYS337J, LYS350J, LYS351J, LYS357J, LYS398J, MET236I, MET365J, MET399J, PHE206I, PHE268I, PHE359J, PHE400J, PRO271I, PRO275I, PRO285I, PRO313J, SER235I, SER273I, SER289I, SER335J, SER397J, SER405J, THR216I, THR223I, THR238I, THR333J, THR340J, TRP374J, TYR267I, TYR395J, VAL204I, VAL215I, VAL232I, VAL283I, VAL287I, VAL295I, VAL336J, VAL356J, VAL366J, VAL370J, VAL377J, VAL406J
• I-M: ARG266I, ARG565M, ASN567M, LYS220I, TRP525M
• J-M: ALA416J, ALA545M, ARG347J, ARG361J, ARG402J, ARG411J, ARG565M, ASN338J, ASN345J, ASN348J, ASN349J, ASN364J, ASN412J, ASN541M, ASN567M, ASN568M, ASP360J, ASP404J, ASP537M, CYS346J, CYS363J, CYS566M, GLN334J, GLN543M, GLU549M, GLU561M, GLY327J, GLY403J, GLY417J, GLY538M, GLY557M, GLY560M, HIS362J, HIS558M, ILE344J, ILE407J, ILE415J, ILE551M, ILE564M, LEU329J, LEU332J, LEU343J, LEU410J, LEU414J, LEU523M, LEU544M, LEU559M, LEU563M, LYS350J, LYS351J, LYS418J, LYS524M, MET365J, MET527M, MET540M, MET542M, PRO328J, PRO413J, SER335J, SER405J, SER535M, THR340J, THR547M, TRP525M, TYR529M, TYR539M, VAL331J, VAL342J, VAL356J, VAL406J, VAL408J, VAL409J, VAL534M, VAL536M, VAL562M, VAL569M
• K-N: ALA35K, ALA704N, ALA772N, ARG51K, ARG54K, ARG64K, ARG763N, ARG775N, ASN23K, ASN38K, ASN40K, ASN45K, ASN722N, ASN739N, ASN765N, ASP37K, CYS41K, GLN42K, GLN60K, GLU26K, GLU34K, GLU36K, GLU59K, GLU708N, GLU771N, GLU774N, GLY65K, GLY724N, GLY764N, HIS705N, HIS726N, ILE33K, ILE46K, ILE63K, ILE68K, ILE767N, ILE768N, LEU58K, LEU709N, LEU717N, LEU719N, LEU721N, LEU740N, LEU770N, LYS67K, LYS711N, LYS715N, LYS720N, MET43K, MET738N, MET769N, PHE712N, PHE734N, PHE737N, PRO706N, PRO707N, PRO736N, SER44K, SER66K, SER718N, SER751N, SER766N, THR22K, THR24K, TYR28K, TYR50K, TYR62K, VAL27K, VAL48K, VAL61K, VAL776N
• L-M: ALA661L, ARG573M, ARG671L, ARG676L, ASN506M, ASN512M, ASN541M, ASN567M, ASN568M, ASN655L, ASN683L, ASP552M, ASP651L, ASP659L, ASP682L, CYS566M, GLN626L, GLN638L, GLN673L, GLU528M, GLU576M, GLU637L, GLU652L, GLU663L, GLY526M, GLY538M, GLY553M, GLY574M, GLY649L, GLY675L, GLY681L, ILE572M, ILE643L, ILE647L, ILE648L, ILE677L, ILE684L, LEU505M, LEU511M, LEU514M, LEU523M, LEU533M, LEU570M, LEU635L, LEU656L, LEU658L, LEU674L, LEU679L, LYS508M, LYS517M, LYS522M, LYS524M, LYS672L, LYS680L, MET520M, MET540M, MET542M, MET641L, MET654L, MET678L, PHE510M, PHE650L, PRO504M, PRO507M, PRO509M, SER629L, THR515M, THR685L, TRP525M, TYR539M, TYR550M, TYR571M, TYR653L, VAL519M, VAL521M, VAL536M, VAL569M, VAL575M, VAL639L, VAL657L
• L-N: ALA749N, ARG623L, ARG628L, ARG642L, ARG725N, ARG732N, ARG763N, ASN619L, ASN640L, ASN655L, ASN683L, ASN692L, ASN722N, ASN739N, ASN755N, ASN756N, ASN765N, ASP682L, ASP735N, CYS745N, GLN638L, GLN688L, GLU637L, GLU652L, GLU747N, GLY681L, GLY723N, GLY733N, GLY758N, GLY764N, HIS705N, ILE618L, ILE621L, ILE684L, ILE742N, ILE757N, ILE762N, ILE767N, LEU620L, LEU625L, LEU656L, LEU686L, LEU687L, LEU709N, LEU719N, LEU721N, LEU731N, LEU740N, LYS680L, LYS710N, MET654L, MET713N, MET738N, MET759N, PHE622L, PHE734N, PHE737N, PRO706N, PRO736N, SER689L, SER691L, SER766N, THR685L, TRP634L, TYR624L, TYR636L, TYR653L, VAL690L, VAL727N, VAL741N, VAL746N, VAL760N, VAL761N
• L-S: ARG628L, ARG628S, ARG630L, ARG630S, ASN627L, ASN627S, ASN692L, ASN692S, ASP659S, ASP660S, CYS646S, GLN626L, GLN626S, GLN632L, GLN632S, GLU644L, GLU644S, GLY645S, ILE631L, ILE631S, LEU625S, SER629L, SER629S, SER689L, SER689S, SER691L, SER691S, TYR624L, TYR624S, VAL615S, VAL633S, VAL690L, VAL690S
• L-U: ARG630L, ARG732U, ASP743U, GLU744U, ILE631L, MET759U
• N-S: ARG630S, ARG732N, ASN756N, ASP743N, CYS745N, GLU744N, GLY758N, ILE631S, ILE648S, ILE742N, ILE757N, MET759N, SER629S, VAL746N
• O-P: ARG118O, ARG149O, ARG173O, ARG250P, ARG261P, ASN176O, ASN221P, ASN237P, ASN249P, ASN263P, ASN264P, ASP123O, ASP233P, CYS119O, GLN122O, GLN254P, GLU175O, GLU183O, GLU256P, GLY124O, GLY174O, GLY231P, GLY262P, HIS112O, HIS137O, HIS239P, ILE120O, ILE126O, ILE229P, ILE260P, ILE265P, LEU110O, LEU121O, LEU140O, LEU177O, LEU219P, LEU240P, LEU247P, LEU255P, LEU258P, LYS105O, LYS108O, LYS136O, LYS150O, LYS152O, LYS220P, LYS241P, LYS248P, MET109O, MET117O, MET138O, MET180O, MET208P, MET245P, PHE134O, SER106O, SER107O, SER179O, SER211P, SER235P, SER259P, THR181O, THR223P, THR228P, THR230P, THR238P, THR257P, VAL178O, VAL182O, VAL225P, VAL232P, VAL234P, VAL243P, VAL253P
• O-Q: ARG347Q, GLN122O
• O-R: ALA133O, ALA13R, ALA193O, ALA35R, ALA80R, ARG116O, ARG125O, ARG165O, ARG173O, ARG194O, ARG29R, ARG51R, ARG64R, ARG69R, ASN139O, ASN176O, ASN23R, ASN38R, ASN40R, ASN79R, ASN88R, ASN90R, ASP114O, ASP123O, ASP135O, ASP144O, ASP189O, ASP75R, CYS143O, CYS145O, CYS20R, CYS41R, GLN122O, GLN91R, GLU147O, GLU175O, GLU21R, GLY168O, GLY174O, GLY191O, GLY25R, GLY4R, GLY65R, HIS137O, ILE113O, ILE141O, ILE192O, ILE63R, ILE68R, ILE72R, ILE7R, LEU10R, LEU121O, LEU140O, LEU142O, LEU167O, LEU169O, LEU171O, LEU172O, LEU32R, LEU71R, LEU73R, LEU77R, LEU83R, LYS132O, LYS136O, LYS188O, LYS67R, LYS84R, LYS87R, LYS89R, MET138O, MET39R, MET76R, MET82R, MET86R, PHE127O, PHE131O, PHE134O, PHE70R, PRO186O, PRO187O, PRO6R, PRO74R, PRO81R, SER66R, SER85R, THR130O, THR190O, THR19R, THR22R, THR24R, TYR115O, VAL166O, VAL170O, VAL18R, VAL195O, VAL27R, VAL5R, VAL9R
• O-U: ASN765U, GLU175O
• P-Q: ALA294P, ALA358Q, ARG205P, ARG261P, ARG266P, ARG292P, ARG347Q, ARG355Q, ARG361Q, ARG394Q, ARG402Q, ASN221P, ASN237P, ASN263P, ASN264P, ASN338Q, ASN339Q, ASN348Q, ASN349Q, ASN364Q, ASN369Q, ASP272P, ASP277P, ASP282P, ASP360Q, ASP404Q, CYS346Q, CYS363Q, GLN224P, GLN341Q, GLU213P, GLU218P, GLU284P, GLU293P, GLU368Q, GLU372Q, GLY222P, GLY262P, GLY354Q, GLY403Q, HIS362Q, ILE217P, ILE260P, ILE265P, ILE269P, ILE396Q, LEU203P, LEU207P, LEU210P, LEU219P, LEU270P, LEU274P, LEU276P, LEU279P, LEU280P, LEU352Q, LEU367Q, LEU401Q, LYS202P, LYS220P, LYS286P, LYS288P, LYS290P, LYS291P, LYS337Q, LYS350Q, LYS357Q, LYS398Q, MET236P, MET365Q, MET399Q, PHE206P, PHE268P, PHE359Q, PHE400Q, PRO271P, PRO275P, PRO285P, SER235P, SER273P, SER289P, SER335Q, SER397Q, SER405Q, THR216P, THR333Q, THR340Q, THR375Q, TRP374Q, TYR267P, TYR395Q, VAL204P, VAL215P, VAL234P, VAL283P, VAL287P, VAL295P, VAL336Q, VAL356Q, VAL366Q, VAL370Q, VAL406Q
• P-T: ARG266P, TRP525T
• Q-T: ALA545T, ARG347Q, ARG361Q, ARG402Q, ARG411Q, ARG565T, ASN345Q, ASN348Q, ASN349Q, ASN364Q, ASN412Q, ASN541T, ASN546T, ASN567T, ASN568T, ASP360Q, ASP404Q, ASP537T, CYS346Q, CYS363Q, CYS566T, GLN334Q, GLN341Q, GLN543T, GLU528T, GLU548T, GLU549T, GLU561T, GLY327Q, GLY403Q, GLY538T, GLY557T, GLY560T, HIS362Q, HIS558T, ILE344Q, ILE407Q, ILE551T, ILE564T, LEU329Q, LEU332Q, LEU343Q, LEU353Q, LEU410Q, LEU414Q, LEU523T, LEU533T, LEU544T, LEU559T, LEU563T, LYS350Q, LYS351Q, LYS524T, MET365Q, MET527T, MET540T, MET542T, PHE359Q, PRO328Q, PRO413Q, SER330Q, SER335Q, SER405Q, SER535T, THR326Q, THR333Q, THR547T, TRP525T, TYR529T, TYR539T, VAL331Q, VAL342Q, VAL406Q, VAL408Q, VAL409Q, VAL534T, VAL536T, VAL562T, VAL569T
• R-U: ALA56R, ALA704U, ALA772U, ARG54R, ARG64R, ARG763U, ASN23R, ASN38R, ASN40R, ASN722U, ASN739U, ASN765U, ASP37R, CYS20R, CYS41R, GLN42R, GLN60R, GLU26R, GLU34R, GLU36R, GLU59R, GLU708U, GLU771U, GLY65R, GLY724U, GLY764U, HIS705U, HIS726U, ILE33R, ILE46R, ILE63R, ILE767U, ILE768U, LEU58R, LEU717U, LEU719U, LEU721U, LEU740U, LEU770U, LYS67R, LYS711U, LYS715U, LYS720U, MET43R, MET738U, MET769U, PHE712U, PHE734U, PHE737U, PRO707U, PRO736U, SER66R, SER718U, SER766U, THR22R, THR24R, TYR28R, TYR50R, TYR62R, VAL48R, VAL61R
• S-T: ALA661S, ARG573T, ARG671S, ARG676S, ASN506T, ASN512T, ASN541T, ASN567T, ASN568T, ASN640S, ASN655S, ASN683S, ASP552T, ASP651S, ASP659S, ASP682S, CYS566T, GLN626S, GLN638S, GLN673S, GLU528T, GLU577T, GLU637S, GLU652S, GLU663S, GLY513T, GLY526T, GLY538T, GLY553T, GLY574T, GLY649S, GLY675S, GLY681S, ILE572T, ILE643S, ILE648S, ILE677S, ILE684S, LEU505T, LEU511T, LEU514T, LEU523T, LEU533T, LEU570T, LEU635S, LEU656S, LEU658S, LEU674S, LEU679S, LYS508T, LYS517T, LYS522T, LYS524T, LYS672S, LYS680S, MET520T, MET540T, MET542T, MET641S, MET654S, MET678S, PHE510T, PHE622S, PHE650S, PRO504T, PRO507T, PRO509T, SER629S, THR685S, TRP525T, TYR539T, TYR550T, TYR571T, TYR653S, VAL519T, VAL521T, VAL536T, VAL569T, VAL575T, VAL639S, VAL657S
• S-U: ALA749U, ARG623S, ARG628S, ARG642S, ARG725U, ARG732U, ARG763U, ASN619S, ASN640S, ASN655S, ASN683S, ASN692S, ASN722U, ASN739U, ASN755U, ASN756U, ASN765U, ASP682S, ASP714U, ASP735U, CYS745U, GLN616S, GLN638S, GLN688S, GLU652S, GLU708U, GLU747U, GLY681S, GLY723U, GLY733U, GLY758U, GLY764U, HIS705U, ILE618S, ILE621S, ILE684S, ILE742U, ILE757U, ILE762U, ILE767U, LEU620S, LEU625S, LEU656S, LEU686S, LEU687S, LEU709U, LEU719U, LEU721U, LEU731U, LEU740U, LYS680S, LYS710U, MET654S, MET713U, MET738U, MET759U, PHE622S, PHE734U, PHE737U, PRO617S, PRO706U, PRO707U, PRO736U, SER666S, SER689S, SER691S, SER766U, THR685S, TRP634S, TYR624S, TYR636S, TYR653S, VAL633S, VAL690S, VAL727U, VAL741U, VAL760U, VAL761U